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<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYG2</accession>
    <name>B8DYG2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HflK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0003</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">HflC and HflK could encode or regulate a protease.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">HflC and HflK may interact to form a multimeric complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the band 7/mec-2 family. HflK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582430.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351958.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0003"/>
    <dbReference type="EnsemblBacteria" id="ACK41344">
        <property type="protein sequence ID" value="ACK41344"/>
        <property type="gene ID" value="Dtur_0003"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0003"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039173_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYG2"/>
    <dbReference type="OMA" id="WNEPGGN"/>
    <dbReference type="OrthoDB" id="577287at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03404">
        <property type="entry name" value="SPFH_HflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010201">
        <property type="entry name" value="HflK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF2">
        <property type="entry name" value="PTHR43327:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01933">
        <property type="entry name" value="hflK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="6">
        <location>
            <begin position="34"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="37318" checksum="91369271466A5E8A" modified="2009-03-03" version="1">MQNFPDFQFPKNNLSIKTIFTIIIVVILLVLVFSSFYFVGPAEVGIVKRFGKIIGMYDPGIHWKIPLIDQVIKIDVSAIRRLEIGFRTITLGPPPQYRDVKEESLLLTKDGKIVDLDFVVQYQITDAVSYLSNVKGEEKLLRDLAQASMRQIVGGYEFDEILTVSKEEIQNNVKTLLQNLLNNNNFGVKIVNVQLQDVVPPEPVQPAFQDVINAKSEKDKLILEAQAYYNQIVPEAEGQAAKIIAEAEAYMDQQIERAKGDAQRFKALLERYKNSPSLIRTKLYLEAMEMVLPKTKIIIIDDPKGSMKIYSFPSELFTSTITLQEGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYG4</accession>
    <name>B8DYG4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEGA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582432.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351960.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0005"/>
    <dbReference type="EnsemblBacteria" id="ACK41346">
        <property type="protein sequence ID" value="ACK41346"/>
        <property type="gene ID" value="Dtur_0005"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0005"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.5"/>
    <dbReference type="eggNOG" id="COG1470">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402121_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYG4"/>
    <dbReference type="OMA" id="WLNKPEG"/>
    <dbReference type="OrthoDB" id="1105830at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025493">
        <property type="entry name" value="DUF4384"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013229">
        <property type="entry name" value="PEGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14326">
        <property type="entry name" value="DUF4384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08308">
        <property type="entry name" value="PEGA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4384" evidence="2">
        <location>
            <begin position="60"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="197"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="265"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="335"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="405"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PEGA" evidence="1">
        <location>
            <begin position="475"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="684" mass="77854" checksum="5C55B52821513100" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYM7</accession>
    <name>B8DYM7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582495.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352023.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0071"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41409">
        <property type="protein sequence ID" value="ACK41409"/>
        <property type="gene ID" value="Dtur_0071"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0071"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.72"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_17_4_0"/>
    <dbReference type="InParanoid" id="B8DYM7"/>
    <dbReference type="OMA" id="YNFANRV"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="236" mass="28143" checksum="18F80E190C652306" modified="2009-03-03" version="1">MKEVFFSIVIPAHNEELYIDKTINSLREMEYLKDRLEVIIVENGSTDNTLEVIKKLAPPWFKIISIKEAGVSKAKNTGIENLSSESEWVIFLDADTYLGQSFLKDLSEFLRKNEDKNLGCGMVSLLPYPDYKLARCWYHFYNFANRVTKTTRSIQIIRRDLLKDLRFDENLTFDEDTMMIRACRKRAKYFFFKTKKVFSSTRRFEKNGWVKQLLQWIYYASLPYEKKKKIKYKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYN3</accession>
    <name>B8DYN3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH ubiquinone oxidoreductase 20 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582501.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352029.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0077"/>
    <dbReference type="EnsemblBacteria" id="ACK41415">
        <property type="protein sequence ID" value="ACK41415"/>
        <property type="gene ID" value="Dtur_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0077"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.78"/>
    <dbReference type="eggNOG" id="COG1941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093095_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYN3"/>
    <dbReference type="OMA" id="GCEISFL"/>
    <dbReference type="OrthoDB" id="1280734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="14"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="180" mass="20042" checksum="AE1F851067402DCF" modified="2009-03-03" version="1">MGKIKVASIWCEGCSGCHMSFLDMDERLVELINKGLEINATPITDLKIPDEETDIGIIEGAVATDHHEEEVKMMRERCKIIVALGDCAVFGGIPTMRNYFSKEELLERGYITTESTVDGKIPTSKEIGKHLPKTKAVNEVIKVDLYIPGCPPSADAIYYVLKEVLEGRIPKLEGELLKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYN6</accession>
    <name>B8DYN6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_0080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582504.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352032.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0080"/>
    <dbReference type="EnsemblBacteria" id="ACK41418">
        <property type="protein sequence ID" value="ACK41418"/>
        <property type="gene ID" value="Dtur_0080"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0080"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.81"/>
    <dbReference type="eggNOG" id="COG0068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009164_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYN6"/>
    <dbReference type="OMA" id="VQHHYAH"/>
    <dbReference type="OrthoDB" id="48295at2"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="10">
        <location>
            <begin position="3"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="11">
        <location>
            <begin position="193"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK41418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="741" mass="86031" checksum="E442F4D78A7D4FAA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYP3</accession>
    <name>B8DYP3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">IU_nuc_hydro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582511.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352039.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0087"/>
    <dbReference type="EnsemblBacteria" id="ACK41425">
        <property type="protein sequence ID" value="ACK41425"/>
        <property type="gene ID" value="Dtur_0087"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0087"/>
    <dbReference type="eggNOG" id="COG1957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2751317_0_0_0"/>
    <dbReference type="OrthoDB" id="1763387at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="1">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="70" mass="7764" checksum="B6F74DC928F638F8" modified="2009-03-03" version="1">MNKIPVILDTDIGTDMDDTWALAMLLNSPELDPKLITTVNGDTLYRAKLVAKLLKIAGKKIPTKMEPKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYP6</accession>
    <name>B8DYP6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582514.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352042.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0090"/>
    <dbReference type="EnsemblBacteria" id="ACK41428">
        <property type="protein sequence ID" value="ACK41428"/>
        <property type="gene ID" value="Dtur_0090"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0090"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.91"/>
    <dbReference type="eggNOG" id="COG0309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049733_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYP6"/>
    <dbReference type="OMA" id="CGNGGKE"/>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046892">
        <property type="term" value="P:peptidyl-S-carbamoyl-L-cysteine dehydration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="48"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="161"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="333" mass="36769" checksum="E15B616E79065F56" modified="2009-03-03" version="1">MEDMILLSHGSGGESTRKLIEEEILKYFGNELLNELYDSSIFETSGRLALTTDSFVISPIFFNGGDIGKLSIYGTINDLSVMGAKPLYLSVGFIIEEGLTLREFREILKSMKLASEECGVKIITGDTKVVEKGKGDKIFINTSGLGIIEEGMDWRGREIKEQDVVIINGGIGEHGLCIMLQRLGIKTDAEVKSDLAPLNSLTLPLLKISSGIKFMRDPTRGGVAGVLNEIAQKYNVEIEVNEESLPIKSWVKSASEILGIDPLYSANEGKVVIIADKKEEEKIMNFLKAHPLGKDAKVIGEVKGKGRRVYLRTRIGTRRILDPLKRDLLPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYW9</accession>
    <name>B8DYW9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="2">4.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">AIR carboxylase</fullName>
            <shortName evidence="2">AIRC</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purE</name>
        <name evidence="6" type="ordered locus">Dtur_0269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIR carboxylase family. Class II subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582680.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352209.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0269"/>
    <dbReference type="EnsemblBacteria" id="ACK41595">
        <property type="protein sequence ID" value="ACK41595"/>
        <property type="gene ID" value="Dtur_0269"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0269"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.282"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_0_0"/>
    <dbReference type="InParanoid" id="B8DYW9"/>
    <dbReference type="OMA" id="TKPVIAC"/>
    <dbReference type="OrthoDB" id="1560434at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043727">
        <property type="term" value="F:5-amino-4-imidazole carboxylate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02045">
        <property type="entry name" value="PurE_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033626">
        <property type="entry name" value="PurE_classII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="5">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2 3">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 3">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2 3">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="157" mass="17543" checksum="456F97B4C2C54612" modified="2009-03-03" version="1">MLVVILMGSKGDLDHAKKIAHTLEKFEVPYVMRVASAHKIPLKVLEIIKEYEEKDVVYITIAGRSNALSGFTDANTTKPVIACPPYSERFGGVDIFSTLRMPSGVAPLTILEPEEAALAAVKILAMKYENLKEKIKKYHEEKRKEIEKADEEVRSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYX0</accession>
    <name>B8DYX0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="7">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purC</name>
        <name evidence="9" type="ordered locus">Dtur_0270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582681.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352210.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0270"/>
    <dbReference type="EnsemblBacteria" id="ACK41596">
        <property type="protein sequence ID" value="ACK41596"/>
        <property type="gene ID" value="Dtur_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0270"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.283"/>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYX0"/>
    <dbReference type="OMA" id="CIATAYF"/>
    <dbReference type="OrthoDB" id="1127677at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="8">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="338" mass="39559" checksum="02878AE663E86668" modified="2009-03-03" version="1">MGSVKDLIIIESPTEKSLGRGRFVFSDRYSVFDYGEMPDHIDDKGKAICIATAYFFEKLENLGIKTHYVGLVEDDKIKTLYELKKPTNVMEFKMVRVIKPDLKDNIYDYSVFKKEKSNFLIPLEVIYRNSLPEGSSIFKRLKEGSLTLQDIGLEEMPEPGQKLEKPIVDFSTKLEVNDRYLSRKEALEISGLYESEFEKLINLTLFIDDLITEETRKINLNNEDGKVEYALDLERNIMLVDALGTLDECRFTFEGIPVSKEIARIYYRKTDWYKEIEEAKKKDRFHWKDYVSSPPQLPKQIRELISLIYKAYANELTGIEWFETSPLKDLLYRVKELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYX7</accession>
    <name>B8DYX7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.78</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
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    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0277"/>
    <dbReference type="CAZy" id="CBM35">
        <property type="family name" value="Carbohydrate-Binding Module Family 35"/>
    </dbReference>
    <dbReference type="CAZy" id="GH26">
        <property type="family name" value="Glycoside Hydrolase Family 26"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41603">
        <property type="protein sequence ID" value="ACK41603"/>
        <property type="gene ID" value="Dtur_0277"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0277"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.290"/>
    <dbReference type="eggNOG" id="COG4124">
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
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    </dbReference>
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        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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        <property type="entry name" value="CMB_fam6"/>
    </dbReference>
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        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
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        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
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        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
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        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16990">
        <property type="entry name" value="CBM_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CBM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM6" evidence="5">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="GH26" evidence="6">
        <location>
            <begin position="162"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="469" mass="54121" checksum="BFC48E1AB5A80717" modified="2009-03-03" version="1">MKFLLILLITFILIFSLNFSTDEIVVEAENGVLNGTYVAKNLPGYQGTGYVDGFDRDGDSCTITFEVKEAGMYELIIGYAAPYGYKENSLYVNGVFQTNVKFPPSQSFTTVYGGLIPLKSGKNTISIVKSWGWFLLDYFKIKKAELPTMNPTNKLVTPNPSKEAQKLMDYLVSIYGKYTLSGQMGYKDAFWIWNITDKFPAICGFDMIDYSPSRVERGASSRDVEDAIDWWNMGGIVQFQWHWNAPKGLYDTPGKEWWRGFYTNATSFDIEYALNHPESEDYKLIIRDIDAIAVQLKRLQEARVPILWRPLHEAEGRWFWWGAKGPEPCKKLWRLLFDRLVNYHKINNLIWVWTTTDSPDALKWYPGDEYVDIVGADVYLNDKNYSPSTGMFYNIVKIFGGKKLVALTENGIIPDPDLMKEQKAYWAWFMTWSGFENDPNKNEISHIKKVFNHPFVITKDELPNLKVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYX9</accession>
    <name>B8DYX9_DICTD</name>
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        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352219.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0280"/>
    <dbReference type="EnsemblBacteria" id="ACK41605">
        <property type="protein sequence ID" value="ACK41605"/>
        <property type="gene ID" value="Dtur_0280"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0280"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.293"/>
    <dbReference type="eggNOG" id="COG1230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYX9"/>
    <dbReference type="OMA" id="GHEKMLH"/>
    <dbReference type="OrthoDB" id="948593at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071577">
        <property type="term" value="P:zinc ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="207"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="291" mass="32358" checksum="5F74C80C1CA17D80" modified="2009-03-03" version="1">MEVKRILGAMFLNLFMALLEVLGGVFSGSLALISDALHNINDFFALLISYLAEIISKNKKSNLNHTFGFRRVEILAALLNGVLLLGVFLFLIIEAFGRIKSPKEVEGIQTVIIGVIGLVGNILGASLLHEDSHHNLNIKGAFLHLLSDAISSVGVIIGALFIIFYRLYVADTIMSLLIAGFILYSSVDLIKETIHILMEGTPKGLNINEIQKIICQISGVKDIHHIHVWQISTKDYLFSAHVVVEDQKISEAQKIISQVKQALKDKFNIHHSTIEIESEDLLKEKECQCEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYZ2</accession>
    <name>B8DYZ2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582703.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352232.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0296"/>
    <dbReference type="EnsemblBacteria" id="ACK41618">
        <property type="protein sequence ID" value="ACK41618"/>
        <property type="gene ID" value="Dtur_0296"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0296"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091969_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYZ2"/>
    <dbReference type="OMA" id="NERNQGV"/>
    <dbReference type="OrthoDB" id="1764098at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="256" mass="29711" checksum="806413AA8A43081F" modified="2009-03-03" version="1">MILKLMKKEWKELVKTGKIYVLLFVFLFFSIGSPVIAKFTPDIIKSLASGSEMQGIIIHLPPPTWKDALLQFFKNLNQIVFIVIVIVFIGSISEEKNRGTASILLSFGVERKKWLLSKFLFQLFVTFIFVLFSYILCAYYTYFLFKEISIYSSLFATLLYLIYVFFVLSLLIFSSSLGKNTIQSAGIFFAIFIIFNLISIFPNLNEYNPMSLSSFENQWILKGVLWKDAIKNIIFTLIYSFILLFLSIIHFENEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ19</accession>
    <name>B8DZ19_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582730.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352259.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0328"/>
    <dbReference type="EnsemblBacteria" id="ACK41645">
        <property type="protein sequence ID" value="ACK41645"/>
        <property type="gene ID" value="Dtur_0328"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0328"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.349"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZ19"/>
    <dbReference type="OMA" id="RMPLMFG"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="278" mass="32247" checksum="0853CEFA294174D5" modified="2009-03-03" version="1">MKVLITGAGGFLGQYFVKEFQDHDVIPLTHKDINIEDKNTIEKIIELKPDLVIHPAAIRSPDICERDPDLAWKVNALGTKHIAIACSILDIPLIYISTDYVFSGDKNSPYTEFDTPNPINVYGRTKLQGELFVKEFCEKYFIIRTSYVFGEYGNNAFTQIYRSLKEGKEIYLSNYHFASCTYAGDLVRKVKELSFTKLYGTYHIVNKGIITRYDFAWKVAEIFNLPKDKIIKLTSENFNQPAPRPLYSVLRNYVLELYHMDDMEHYEEILKKISFLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ57</accession>
    <name>B8DZ57_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar isomerase (SIS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582768.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352297.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0379"/>
    <dbReference type="EnsemblBacteria" id="ACK41683">
        <property type="protein sequence ID" value="ACK41683"/>
        <property type="gene ID" value="Dtur_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0379"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.399"/>
    <dbReference type="eggNOG" id="COG2222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZ57"/>
    <dbReference type="OMA" id="CEVIPLQ"/>
    <dbReference type="OrthoDB" id="1046291at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="189"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="37008" checksum="209CF6451C1A7F14" modified="2009-03-03" version="1">MYIVEKEIKEQITDLPRVFDYVKNYLKSNNLPEFILNSDIIYFIGCGTSLYLSLSGSRFFTFKTNMETKALPGGEIWFSPKENIGDFKNLRRSAILISRSGESTEVVKAGEKFKEYGIPTLGITLEEESSLVKISQNSIVLPIKEDAIVMTKSFSSMLLTIEMIASFVKGEDLSIYKDLLNEIEKIINTANELSSNYTHYNHYIFLGLGAEEGIARESALKLEEMSLSKIEAYSTFEYRHGPKSLLEKGFLVSIYTKGIQAEEPLIDELKSYGAEVITIGGKGSDFYISDLPESLFLKVIWGQILGLNIAKSKNINVESPRNLSKVVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ65</accession>
    <name>B8DZ65_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582776.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352305.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0387"/>
    <dbReference type="EnsemblBacteria" id="ACK41691">
        <property type="protein sequence ID" value="ACK41691"/>
        <property type="gene ID" value="Dtur_0387"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0387"/>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086284_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ65"/>
    <dbReference type="OMA" id="QLGGLAH"/>
    <dbReference type="OrthoDB" id="2047280at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="251" mass="29366" checksum="E580DFE366F7301B" modified="2009-03-03" version="1">MAIPKEELYPIVREIVLQELEVRIPIHKEIVDLKSAVERLISAQEKTEERIEELVQAQRRTEERLEALTEAQRKSEERIARLETAVEALTEAQRKTEEEIRELTLAMKNMQKQINGIAKELGELSHSIDFQLEDRAYRSLPYLLKRDFGIEVKERLIRKFIENKKGEPMEINILGKGERDGKEIFIVGEAKANLSLRHIIDFIDRLKDIREVIEGAIFPIIVTYMTEPETEEFAKSKGITIYYSYDFESIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ70</accession>
    <name>B8DZ70_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SirA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582888.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352417.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0510"/>
    <dbReference type="EnsemblBacteria" id="ACK41803">
        <property type="protein sequence ID" value="ACK41803"/>
        <property type="gene ID" value="Dtur_0510"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0510"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ70"/>
    <dbReference type="OMA" id="VCPYPQL"/>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01148">
        <property type="entry name" value="UPF0033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="78" mass="8832" checksum="B12F4802D08E1808" modified="2009-03-03" version="1">MDVKPNYTLDVRGEVCPVPDVETKRKLKTMQSGEILEVLIDYPLSKERIPQGIKEVGGEVLAIEEIGPSEWRILIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ77</accession>
    <name>B8DZ77_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582895.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352424.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0517"/>
    <dbReference type="EnsemblBacteria" id="ACK41810">
        <property type="protein sequence ID" value="ACK41810"/>
        <property type="gene ID" value="Dtur_0517"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0517"/>
    <dbReference type="HOGENOM" id="CLU_1616385_0_0_0"/>
    <dbReference type="OMA" id="NGMWFFG"/>
    <dbReference type="OrthoDB" id="2121767at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867698" evidence="1">
        <location>
            <begin position="25"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="164" mass="18357" checksum="E86EB6BE68C38461" modified="2009-03-03" version="1">MKRYSKIFLSAFLTLVLLFSLNFAQTSPKIYINKINSPDGGLIEPARAKLIDILMSKGYVVTGNKDEANYMLDLIIVSANSRRSFNWVFLILPIWPIVPITTVQGEAVVAVRVFDQQGNEVLFDQTGVVKNGMWFFGDFVSGSSVIKGAVIDCINILTFRMNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZB1</accession>
    <name>B8DZB1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582929.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352458.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0554"/>
    <dbReference type="EnsemblBacteria" id="ACK41844">
        <property type="protein sequence ID" value="ACK41844"/>
        <property type="gene ID" value="Dtur_0554"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0554"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZB1"/>
    <dbReference type="OMA" id="YSMINRW"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051596">
        <property type="term" value="P:methylglyoxal catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="28"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="37637" checksum="B52C0F7016367E76" modified="2009-03-03" version="1">MIYVADSKRYEVMIYRRCGKSGLKLPAISLGFWHNFGYNDSFENMRNMVRKAFDLGITHFDLANNYGPPPGSAEENFGRILKFDLKPYRDEIVISTKAGYKMWDGPYGDFGSKKYLIASLEQSLKRMGLDYVDIFYHHRPDPETPIEETMEALYQIVRQGKALYVGISNYGPEETKLAYETLSKMGVRLIVNQILYNMFFRKPEEKLFGVMEELGIGATIFSPLAQGLLTEKYLNGIPEDSRVKRSGIFLKESDITPEKIEKVRKLSQIAKERGQSVAQLAISWILRNNVVSSVIIGASKPEQIEENVKAISILKFSEEELKRIDEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZB8</accession>
    <name>B8DZB8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Redox-sensing transcriptional repressor Rex</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rex</name>
        <name evidence="8" type="ordered locus">Dtur_0561</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transcriptional regulatory Rex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582936.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352465.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0561"/>
    <dbReference type="EnsemblBacteria" id="ACK41851">
        <property type="protein sequence ID" value="ACK41851"/>
        <property type="gene ID" value="Dtur_0561"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0561"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.597"/>
    <dbReference type="eggNOG" id="COG2344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061534_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZB8"/>
    <dbReference type="OMA" id="GKPKVGY"/>
    <dbReference type="OrthoDB" id="1872374at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051775">
        <property type="term" value="P:response to redox state"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01131">
        <property type="entry name" value="Rex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009718">
        <property type="entry name" value="Rex_DNA-bd_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022876">
        <property type="entry name" value="Tscrpt_rep_Rex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35786">
        <property type="entry name" value="PTHR35786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06971">
        <property type="entry name" value="Put_DNA-bind_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CoA_binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="83"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="208" mass="23338" checksum="5B87170CBBC05ECA" modified="2009-03-03" version="1">MFPKATLERLKLYHRLLSEEKEEYISSEEIGGRLGIPPEQVRKDLSYLEYKGKPKVGYHVKSLLDELNRLFGLDKKVKVIIVGAGNLGTALTNYPGFSNYNIEIVGIFDKDPAKIGKKVGDLVVLPMEYLERVIKRFNVEIGAICVPKESAQEVANLLVENGIKAIWNFAPALISVPEYVIVRNEDITLGLLSLKHMLEVKNTQSKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZC3</accession>
    <name>B8DZC3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0566</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352470.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0566"/>
    <dbReference type="EnsemblBacteria" id="ACK41856">
        <property type="protein sequence ID" value="ACK41856"/>
        <property type="gene ID" value="Dtur_0566"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0566"/>
    <dbReference type="eggNOG" id="ENOG502ZD61">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2166952_0_0_0"/>
    <dbReference type="OMA" id="WFFKEEI"/>
    <dbReference type="OrthoDB" id="2092991at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="110" mass="12586" checksum="A5DBF84B6ED5A6B8" modified="2009-03-03" version="1">MAVFISFALCIMFTVISNVSFKLSVQNKDLKNFIFWQVIGNLTGFFSVIAYTYLLTLVPFYIGYALTTAFGQIFVQVFGAKWFFKEEILPSQWIGIILIMIGTLFLVKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZD7</accession>
    <name>B8DZD7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582955.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352484.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0582"/>
    <dbReference type="EnsemblBacteria" id="ACK41870">
        <property type="protein sequence ID" value="ACK41870"/>
        <property type="gene ID" value="Dtur_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0582"/>
    <dbReference type="HOGENOM" id="CLU_3117229_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="50" mass="5971" checksum="685CC338E3995DF0" modified="2009-03-03" version="1">MRNTFKNESWVCINKGKVYGRNLIKIILVVGVRPQFRKLAEEEYNKDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZI1</accession>
    <name>B8DZI1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582999.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352528.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0626"/>
    <dbReference type="EnsemblBacteria" id="ACK41914">
        <property type="protein sequence ID" value="ACK41914"/>
        <property type="gene ID" value="Dtur_0626"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0626"/>
    <dbReference type="eggNOG" id="COG1402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_3_0_0"/>
    <dbReference type="InParanoid" id="B8DZI1"/>
    <dbReference type="OMA" id="GMEMFAK"/>
    <dbReference type="OrthoDB" id="984747at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="241" mass="28332" checksum="6E5ACDE13C9D9AC0" modified="2009-03-03" version="1">MLKYRYESMFPYHLREVLEKNPIVYLPVSPLEWHGEHLIFGTDPFRARKLLELVWERLGGVLMPTLYVGTDSTLVEDGEEFWGMEMFAKERIPGSIFVRKETFYNLLKDILNFLERTGFKLCILCTGHMAKPQIEVVERLEEEHKERNMRVLSWHWGKVNYPKELMTPNPLHAGVEESSEILSIDLSYVDLDRIGSMEVDRKVSLLKENLKGISETLGIKRFNFEVEELIKEIMKCYNKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZJ1</accession>
    <name>B8DZJ1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583009.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352538.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0639"/>
    <dbReference type="EnsemblBacteria" id="ACK41924">
        <property type="protein sequence ID" value="ACK41924"/>
        <property type="gene ID" value="Dtur_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0639"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_5_0_0"/>
    <dbReference type="InParanoid" id="B8DZJ1"/>
    <dbReference type="OMA" id="CFVAYYR"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="129"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="321" mass="36423" checksum="1CEAA21E9134B8E8" modified="2009-03-03" version="1">MRWGIVGTGRIVRDRFLPALEQVPGAKLTAIVTTNPERAKDLSERYGARIYSNLEAVEDVDVIYIATPNKFHKEQTIICAKMGIHVLCEKPMALSVKEAEEMVEECKRNKVILGIANMGRFNPFNIGAKKLLEENIVGKIGIIKASFSFVNNERNAWRYSLDLAGGGAIMDIGVHVINTLHFWFPNNKVEEIVAINEHYGYEVEQNAGAVVRFDNGMMALLDVSYDTMLSVSFEIRGDEGILYILDTLYQEYDGKVILRRFNNYTFYNFYGENQYVAEIKDTEEAIKEGREPATSGTDGLKDMRVIEGWYESAKEKKLVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZJ9</accession>
    <name>B8DZJ9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KHG/KDPG aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583017.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352546.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0647"/>
    <dbReference type="EnsemblBacteria" id="ACK41932">
        <property type="protein sequence ID" value="ACK41932"/>
        <property type="gene ID" value="Dtur_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0647"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.685"/>
    <dbReference type="eggNOG" id="COG0800">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077795_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZJ9"/>
    <dbReference type="OMA" id="FFPAEYC"/>
    <dbReference type="OrthoDB" id="1497385at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00452">
        <property type="entry name" value="KDPG_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000887">
        <property type="entry name" value="Aldlse_KDPG_KHG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031338">
        <property type="entry name" value="KDPG/KHG_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30246">
        <property type="entry name" value="PTHR30246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01081">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01182">
        <property type="entry name" value="eda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00160">
        <property type="entry name" value="ALDOLASE_KDPG_KHG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="215" mass="23221" checksum="EACDA97C195A461A" modified="2009-03-03" version="1">MGDRFDILQKMIDCGIVAVIRTDSPDDLIPVTKALKEGGVIALEVTMTVPSAIEYLPKVKKELGKDAIVGMGTVLDPETARLAILAGADFIVSPVLKKEIINLCHRYDKIAIPGAYTPTEILTAWEEGADVVKLFPADTLGPKYIKAIHGPMPYIRISPTGGVSLENVGEFIKAGACFVGVGGNLVDKKVIAEKKFEILTERAKEYIEAIKKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZK1</accession>
    <name>B8DZK1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583019.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352548.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0649"/>
    <dbReference type="CAZy" id="GH94">
        <property type="family name" value="Glycoside Hydrolase Family 94"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41934">
        <property type="protein sequence ID" value="ACK41934"/>
        <property type="gene ID" value="Dtur_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0649"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.687"/>
    <dbReference type="eggNOG" id="COG3459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019054_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZK1"/>
    <dbReference type="OMA" id="YVYAQMI"/>
    <dbReference type="OrthoDB" id="136681at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11754">
        <property type="entry name" value="GH94N_CBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037825">
        <property type="entry name" value="GH94N_CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM_X" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="811" mass="93977" checksum="9469BF22F7A25957" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZL6</accession>
    <name>B8DZL6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583034.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352563.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0664"/>
    <dbReference type="EnsemblBacteria" id="ACK41949">
        <property type="protein sequence ID" value="ACK41949"/>
        <property type="gene ID" value="Dtur_0664"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0664"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.702"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398890_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZL6"/>
    <dbReference type="OMA" id="YWQAQHI"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="75"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="647" mass="74506" checksum="900D884CF35C5E04" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZM1</accession>
    <name>B8DZM1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellulase</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583039.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352568.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0669"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41954">
        <property type="protein sequence ID" value="ACK41954"/>
        <property type="gene ID" value="Dtur_0669"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0669"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.707"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018668_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZM1"/>
    <dbReference type="OMA" id="HYYDPWD"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006073">
        <property type="term" value="P:cellular glucan metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="332" mass="39441" checksum="2F7E09B1BF39AE12" modified="2009-03-03" version="1">MRRILWIILLTLFIFNINGYTQEKLPIRRGVNLTGLEAPFEGSWGVYVKDEYFELVKKAGFDHIRVPIRWNGHAAYEPPYTIRDYLFERVDHIIEMAFKNKLYIIINIHNYEELMQNPEKHKERFLALWRQIAEHYKNYPDTLWFELLNEPNTNLTPQLWNEYLAEAVKVIRETNPTRKIVIDTANWANYNTISFLKLPQDRNLIVSFHYYNPFNFTHQGADWVQPQLPVGVKWTGSDQEKKAIERELDFTLEWAKRNGNVLLYMGEFGAYSKADMESRVRWTDFVARSAEKRGIAWSYWDFASAGFGVYDGLNKMWRIELLKALIPETKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZN5</accession>
    <name>B8DZN5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endonuclease III</fullName>
            <ecNumber evidence="10">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-(apurinic or apyrimidinic site) lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nth</name>
        <name evidence="12" type="ordered locus">Dtur_0683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583053.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352582.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0683"/>
    <dbReference type="EnsemblBacteria" id="ACK41968">
        <property type="protein sequence ID" value="ACK41968"/>
        <property type="gene ID" value="Dtur_0683"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0683"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.721"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_3_0"/>
    <dbReference type="InParanoid" id="B8DZN5"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00942">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005759">
        <property type="entry name" value="Nth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01083">
        <property type="entry name" value="nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="11">
        <location>
            <begin position="38"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK41968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="210" mass="24311" checksum="9514BE9D1642EB9C" modified="2009-03-03" version="1">MDKREQVIEILKRLRTIYEPKIALKFSNPWELLVATILSAQTTDERVNMVTEKLFKKYRSPEDYLKVSLEELEQDIRSVNYYKTKAKNIRACAQIIVEKYNGKVPDTMEELLKLPGVARKTANVVLSAGYGKNEGIVIDTHVNRLSKRLNLGKEKNRDKLEQELMKIVPKDEWANFSYLLIHHGRNVCKAKNPKCDECILKDICPSAFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZN6</accession>
    <name>B8DZN6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583054.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352583.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0684"/>
    <dbReference type="EnsemblBacteria" id="ACK41969">
        <property type="protein sequence ID" value="ACK41969"/>
        <property type="gene ID" value="Dtur_0684"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0684"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.722"/>
    <dbReference type="eggNOG" id="COG1453">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_2_0"/>
    <dbReference type="InParanoid" id="B8DZN6"/>
    <dbReference type="OMA" id="YYYFFQR"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="376" mass="43740" checksum="A45555B86029ED58" modified="2009-03-03" version="1">MKYRKMGKLDVTVSVLGFGAMRLPTLGTESQIDEPKAIEMIRYAIDHGVNYVDTAYGYHGGQSEILVGKALKNGYREKTYLATKLPVWFVNKKEDMDRLLNEQLKKLDTDHIDFYLLHALNKDSWQKIYNLGAIEWGEKMKEKGFIRYFGFSFHDDLETFKKIIDTHDWDFCQIQYNYMDIDYQAGKEGLEYAGKKGIGVIVMEPLRGGRLARPPKDVMELIEKYPTKRSPVEWALLWVWNHKEVSLALSGMSTLDQVKENLEIADKAEVNIFSKEDLEFIEKVRLAFLGRRAIDCTQCRYCMPCPYGVDIPRNFYIYNEGVRYDDWGAPRWEYNNAMKPEERAENCKKCGECETKCPQGLAIRDLLEMVHNTLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZP9</accession>
    <name>B8DZP9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583067.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352596.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0697"/>
    <dbReference type="EnsemblBacteria" id="ACK41982">
        <property type="protein sequence ID" value="ACK41982"/>
        <property type="gene ID" value="Dtur_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0697"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="InParanoid" id="B8DZP9"/>
    <dbReference type="OMA" id="AYCYSTE"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="1">
        <location>
            <begin position="216"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="408" mass="45271" checksum="D435D53C94C785E0" modified="2009-03-03" version="1">MKAVWFEESIPRYLISKALGKVHHSFYYNIFSCIRYGEYPEPKLPSGKWVKIKTLMGGICGSDIGLIRLHDSPSTSPFASFPFVIGHENLGIIVEKGDEVEGFEVGDRVIADPTLSCNAREIYPPCEKCQNFEFSQCMNFNEGIVSPGLMIGSCRDTGGSWGEYYVANQFQLFKVPDKVSNENAILVDAFCSALHPVMRNFPKDSDTVIVVGSGSIGINVVSALRALGSKTRIIVLARYKFQGEFAKHYGADEVVYTKGLNKWELYKKVAELTSAKLLKPLLGKPVMVGGADVVFECVGSDDSIDDALRFTKQGGTTVLVGLAGVTKRVDWTFVWFKELRVAGTNSSSGEIFRGERKRGYGIALQLMEEGLDLSPLLTHTFKLEEYKKAIEMNFFRGKYGLIKSAFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZS3</accession>
    <name>B8DZS3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583091.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352620.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0722"/>
    <dbReference type="EnsemblBacteria" id="ACK42006">
        <property type="protein sequence ID" value="ACK42006"/>
        <property type="gene ID" value="Dtur_0722"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0722"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.760"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862580_0_0_0"/>
    <dbReference type="OrthoDB" id="229116at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="322" mass="37441" checksum="B14FD30D3D807149" modified="2009-03-03" version="1">MTLALLYLLNYDNNPYYNSEDILKFINGGVNFWCKIQRKNGSFDEWYPYEGSFVATAFSTCAISEVLLLLKEKIANFDNSLRCIKKAVDFLSKNVDYTACNQEAGAILAIYNCYLLTSESKYRDLAYKRLNDLSKLQKEEGWFPEYGGPDIGYLSLTIDYLAKVYEKSNWDLAKEMLTKAIDFLYYFSHPDGSFGAEYGSRNTKYIIPSGIEFIAPWNRKAGYIAFNLRRALFEKKTIGPYNLDDRYLAYIGYTYLQASLYFREDLEVEERGHVDKYFEESGIWVFSNSSFYLVSNFKKGGVLKVNFKNGSSFKDKWDYFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZT0</accession>
    <name>B8DZT0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583098.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352627.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0730"/>
    <dbReference type="EnsemblBacteria" id="ACK42013">
        <property type="protein sequence ID" value="ACK42013"/>
        <property type="gene ID" value="Dtur_0730"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0730"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.769"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019091_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZT0"/>
    <dbReference type="OMA" id="NPVMHHL"/>
    <dbReference type="OrthoDB" id="952726at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="570" mass="63628" checksum="FEC685024FB92F20" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZU2</accession>
    <name>B8DZU2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin reductase domain protein FMN-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583110.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352639.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0743"/>
    <dbReference type="EnsemblBacteria" id="ACK42025">
        <property type="protein sequence ID" value="ACK42025"/>
        <property type="gene ID" value="Dtur_0743"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0743"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_5_3_0"/>
    <dbReference type="InParanoid" id="B8DZU2"/>
    <dbReference type="OMA" id="ICTNPPM"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="12"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="185" mass="21397" checksum="86F415BE6B0E2FB1" modified="2009-03-03" version="1">MYHEVKSNFVYLIHPLPGILITSIGKNNNPNVMSASWITPISINPPLISISLRPERYTYELIKETGDFAINIPDYSLRKAVFICGRYSGRKINKFKKSNLTPIPAKKIRSPIVKECLAHIECTLERIIDLPADHHIIIGRVQYAQAHEEFFKNTYIPEKFKPLLYFGKDIYGTIDTYEHIKTEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E021</accession>
    <name>B8E021_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="2">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0823</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583188.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352718.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0823"/>
    <dbReference type="CAZy" id="GT19">
        <property type="family name" value="Glycosyltransferase Family 19"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42104">
        <property type="protein sequence ID" value="ACK42104"/>
        <property type="gene ID" value="Dtur_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0823"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.862"/>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036577_3_1_0"/>
    <dbReference type="InParanoid" id="B8E021"/>
    <dbReference type="OMA" id="PTVWAWR"/>
    <dbReference type="OrthoDB" id="1258510at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="363" mass="42151" checksum="9CD35C5A9A548D10" modified="2009-03-03" version="1">MKIFLSVLEVSADVHGSKLINALKNKKKDIYFYGLGGERMKEEGMEVMYDVTQYSTVGFIEPIPYIPKLLLVQEKVKKIIKETKPDLIIFIDAQGFNLPLAKYAKKLGIQTIYYFAPQYWLWGNQEKAREVLDTVSYVVATFPQEYNLYKKFGDNVVYFGHPLVDYLLPYENLEKENDLIGLFPGSRIQEIKNLVPLFLEISDRLKEEGYRFVMPIASEKFSEMIFRYIRGKNHIELVSGRESQKYLKLSSLSLVASGTVTLEAAILKTPVMVFYKISSITYNIAKRLVHYSFIALPNIILNQMIYPEFVQKIDIKEVMDSINRILKDEDYKINLENKLRELEFKLGEPGVLERISKFILEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E027</accession>
    <name>B8E027_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352724.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0829"/>
    <dbReference type="EnsemblBacteria" id="ACK42110">
        <property type="protein sequence ID" value="ACK42110"/>
        <property type="gene ID" value="Dtur_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0829"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.868"/>
    <dbReference type="eggNOG" id="COG4372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033222_1_0_0"/>
    <dbReference type="InParanoid" id="B8E027"/>
    <dbReference type="OMA" id="GNYVRGE"/>
    <dbReference type="OrthoDB" id="1465714at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021435">
        <property type="entry name" value="DUF3084"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11283">
        <property type="entry name" value="DUF3084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="396" mass="45409" checksum="AD9FC311263785DD" modified="2009-03-03" version="1">MSGVMLIIILLVASGLIAYAGDYVGRKAGKKKLTIFNLRPKYTSRIISVLTGILIMVFALIVLSVFSENVRIALFGMEKLKKEISTLQLNIKSKEKEFSEIIKKYEAVKEERGRAIKELESYKIKLNELEEDRAKILEELNKLSKEREILCKENEKLQRSIYEISQKISSLSKEREKLLEEKKELLDEIQFLNTTITNMRTEGIVFRRGELILNYISKGDLTEEKAKEEAKVLLSLIENIAKERGAGNEEKGFIWVPEAEWIKLLNAFTTSGEKLIRVFSLANIFEGEPALITFEIYPYKLIFKKGDVLVLKVIDGSEDLNKIESKLLEILSEVNKIAQQKGVLPDPLTNTVGEISFEEFYNIVYKIKEKDKKVLLKVIVDEDTYNSGPLKIRFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E028</accession>
    <name>B8E028_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proline--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="7">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">proS</name>
        <name evidence="9" type="ordered locus">Dtur_0830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583195.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352725.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0830"/>
    <dbReference type="EnsemblBacteria" id="ACK42111">
        <property type="protein sequence ID" value="ACK42111"/>
        <property type="gene ID" value="Dtur_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0830"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.869"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_0"/>
    <dbReference type="InParanoid" id="B8E028"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="SSF64586"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="43"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="480" mass="56225" checksum="060655DCFAA76148" modified="2009-03-03" version="1">MEKKFVEELTSQKEDFSKWYTEVVLKADLVDYSPVKGCMVIKPYGYAIWENMQRILDEKIKETGHVNAYFPLFIPKSFLEKEAEHVEGFSPQVAWVTKGGDEDLFEPLAVRPTSEAIICSMYSKWIQSWRDLPILINQWANVVRWEKETRPFLRTTEFLWQEGHTAHRTFEEAEEEALRMLNVYKEFVENDLAIPVIAGKKTENEKFAGALHTYSIEVLLADGRALQAGTSHNLGQHFAKAFDIMFQDVDGERKYVWQTSWGVSTRLIGALIMTHGDDYGLVLPPRVAPYQIVIIPIWKNETDKVKVYNYIDEIYEVLKKYFRVKVDRDEEHTPGWKFNEWELKGVPVRLEIGPKEVEKQEIYVARRDLRTKISIRRENMIQDLENLLKDIQKTLFERALKFREENTYEINNFEEFKKIMDTKRGFVKASWCGDGECELKIKELTGATIRNIPLDWKEEEGKCILCGRETKIKALFAKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E051</accession>
    <name>B8E051_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein GntR HTH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583218.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352748.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0853"/>
    <dbReference type="EnsemblBacteria" id="ACK42134">
        <property type="protein sequence ID" value="ACK42134"/>
        <property type="gene ID" value="Dtur_0853"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0853"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.892"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_808293_0_0_0"/>
    <dbReference type="OMA" id="IFAANDW"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="343" mass="39861" checksum="605F0757C466EB8E" modified="2009-03-03" version="1">MKISPLIKEKIKEELLKIIEKNRKEDYVKLSSERELAQTFNVSRTTIRSVMKELIEEGIIVQFQGKGTYIVPKKEKHVYVLNSPDLKTEDPFYSKFFVALTNRLTERGFSLNFISMDKVIKNRNRDIPLLLVGLINDESIEKLKEKFQYLISIEQYFNHDKIIQISVDDYKIGWSAAEAFIKRKHNYIIHLCGPERYTAARLRKLGFLDRVKIEEGIKYEIIEGKMNYKSGYELGEKILDIFNNERKSKIGIFAANDWMAIGLIQRLKESGILVGKELSIIGCDDIPLAKEVVPNLTTFKWDVEKIISEIIELLDDIINKKKIISNKRVLVSAKLIIRETLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E081</accession>
    <name>B8E081_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name evidence="2" type="ordered locus">Dtur_0883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583248.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352778.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0883"/>
    <dbReference type="EnsemblBacteria" id="ACK42164">
        <property type="protein sequence ID" value="ACK42164"/>
        <property type="gene ID" value="Dtur_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0883"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.921"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_3_1_0"/>
    <dbReference type="InParanoid" id="B8E081"/>
    <dbReference type="OMA" id="QMDIEQK"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="201" mass="23579" checksum="5056D9AA753AF91E" modified="2009-03-03" version="1">MSYKIGITGGIGTGKTLVINTLKELGIPVISADEIVRELQKDPYYLEKIRKIFGDKVFEEGQLNRKKLAEIIFSDDKERKKLENLLHPPVLTEIKKRLEDFKDKEIVAVEVPLLFEVGIENWFDEIWVVYAPFEIQLERIIKRDNISQEEAIKRIKAQIPIEEKVKKADFVIYNDKDLESTKNQIKNRILSIYRMIYNKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0A7</accession>
    <name>B8E0A7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583634.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353166.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1274"/>
    <dbReference type="EnsemblBacteria" id="ACK42552">
        <property type="protein sequence ID" value="ACK42552"/>
        <property type="gene ID" value="Dtur_1274"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1274"/>
    <dbReference type="HOGENOM" id="CLU_1341484_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0A7"/>
    <dbReference type="OMA" id="MIRRSPY"/>
    <dbReference type="OrthoDB" id="1719698at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026988">
        <property type="entry name" value="YaaC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14175">
        <property type="entry name" value="YaaC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="204" mass="24024" checksum="CF72882206017A1A" modified="2009-03-03" version="1">MIRRSPYKNLLKYEKKLSTNLGEGERFFLHYTLIQAKSNLEIGEKSDYFVSPLLFFYGLVALSKIIILMKSKTIPREVLHGLTVRVAGDKSVDWTKDYDPRVETVLIKEKGLFPTFYKAISPYSLPEGEKYTLGDLFLFLNRKTSLDNLAIHYLILFLLSMLARYEPQKWGWAYERSSFSRELQTYLKIVGRDIYDLWREKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0B7</accession>
    <name>B8E0B7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integrase domain protein SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1284</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583644.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353176.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42562">
        <property type="protein sequence ID" value="ACK42562"/>
        <property type="gene ID" value="Dtur_1284"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1284"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_0"/>
    <dbReference type="InParanoid" id="B8E0B7"/>
    <dbReference type="OMA" id="WCVEENI"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000007719">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="4">
        <location>
            <begin position="106"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="227" mass="26897" checksum="BFA74EFABBCB7F77" modified="2009-03-03" version="1">MKNQVKSWKSLLDNFFFVSQVNGKRPKTLQWYKETLIPFTKSVPLEELSVYSIQKYISSLRERGLKPASIDTHIRAIKSFLHFLYDEGYLEENISAKIKRYKLPKSYPHILNDEQILNLLKVCDKKSWDSFRNYVIVLTFLDTGIRLSELLNLTVNDVNLPKRSIFIRSGKGEKDREVYMGKTLVREMAKWLKMRGYFPYEERVFITKQGYPLNKRGVERIFTKIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0C0</accession>
    <name>B8E0C0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353179.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42565">
        <property type="protein sequence ID" value="ACK42565"/>
        <property type="gene ID" value="Dtur_1287"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1287"/>
    <dbReference type="HOGENOM" id="CLU_2933956_0_0_0"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="60" mass="7232" checksum="92780F612B7723B1" modified="2009-03-03" version="1">MITGQPFYPFFPYTKLFYTTGYAVDPLKYARKLISQKIGTYRFRIGDYRVIFDKDIYKDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0C6</accession>
    <name>B8E0C6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA methylase N-4/N-6 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1294</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583653.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353185.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1294"/>
    <dbReference type="REBASE" id="19435">
        <property type="entry name" value="M.DtuDORF1294P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42571">
        <property type="protein sequence ID" value="ACK42571"/>
        <property type="gene ID" value="Dtur_1294"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1294"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1337"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013151_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0C6"/>
    <dbReference type="OMA" id="DFQKKLW"/>
    <dbReference type="OrthoDB" id="161391at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006306">
        <property type="term" value="P:DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="5">
        <location>
            <begin position="491"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1015" mass="120774" checksum="E67A9C488C1E06BA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0E0</accession>
    <name>B8E0E0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA/rRNA methyltransferase (SpoU)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583667.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353199.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1311"/>
    <dbReference type="EnsemblBacteria" id="ACK42585">
        <property type="protein sequence ID" value="ACK42585"/>
        <property type="gene ID" value="Dtur_1311"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1311"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0E0"/>
    <dbReference type="OMA" id="YHEKTIR"/>
    <dbReference type="OrthoDB" id="1697536at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="269" mass="30998" checksum="7D81D51C1D3DD561" modified="2009-03-03" version="1">MKFISSPSNEVIKEVIKLHDKNKRKKLKKCIVEGWRLIQDAKENGIFIEKLIISKSLWNKRRDEILKSFSSYDLYIVEDNLMEKISLMETPPGIMGVFPLFLFPKWELLEEKNNKIVLFSDDIQDPGNLGTIIRIADGVGVDAVILSENTVDPYNYKVIRGSTGSIFRVPIWVSDKKTFIEFFKGWKVIIADPKGSKVYFQENLRESFVLILGNEAWGTRKEKYIDLDPILLKIPLREGVDSLNVSIAASVFLFEAQRQRYFEGGIKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0F0</accession>
    <name>B8E0F0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recO</name>
        <name evidence="6" type="ordered locus">Dtur_1321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583677.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353209.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1321"/>
    <dbReference type="EnsemblBacteria" id="ACK42595">
        <property type="protein sequence ID" value="ACK42595"/>
        <property type="gene ID" value="Dtur_1321"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1321"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1173926_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0F0"/>
    <dbReference type="OMA" id="EECKDIG"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2 4" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="3 4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_rep/recomb_RecO_N" evidence="5">
        <location>
            <begin position="10"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="236" mass="28164" checksum="B4DB7172216C409C" modified="2009-03-03" version="1">MGLENRYYYEEGIILFKKKVGEGDLLLTIYGKEKGKFLAIARGALKIKNRLRGKVNIFSIGKGYFVKRREVDLLIFWDSYEKFFEIIKDVDKFIILSKYLKKADKFIPLEVKDLEIYEYLYKFLKNWNLINKYSGDVFLIKLLQKLGYISKVELKCKGCDKDLLKDEYVYFDLDNRKIYCEDCRTLKSLKIKSEEVIKFNEILDRTFDELIMGETGFSDKIFNLIDRMIERIEQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0G5</accession>
    <name>B8E0G5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583691.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353224.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1336"/>
    <dbReference type="EnsemblBacteria" id="ACK42610">
        <property type="protein sequence ID" value="ACK42610"/>
        <property type="gene ID" value="Dtur_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1336"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1381"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_0"/>
    <dbReference type="InParanoid" id="B8E0G5"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901565">
        <property type="term" value="P:organonitrogen compound catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="125" mass="13600" checksum="90D4D067C1F58927" modified="2009-03-03" version="1">MKEIISTSKAPSAIGPYSQGIKVGNMVFISGQIPIDPDTGNVVEGGIKEQTKRVLENVKAILESIGGSLNNVVKTTVFMVDLEEFSEMNEVYKEYFPNNPPARSTIQVSALPKNVKIEIEAIAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0K9</accession>
    <name>B8E0K9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine synthase vitamin-B12 independent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584104.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353643.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1757"/>
    <dbReference type="EnsemblBacteria" id="ACK43029">
        <property type="protein sequence ID" value="ACK43029"/>
        <property type="gene ID" value="Dtur_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1757"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1809"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040013_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0K9"/>
    <dbReference type="OMA" id="DPDCGMR"/>
    <dbReference type="OrthoDB" id="577156at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meth_synt_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="342" mass="39366" checksum="E1362CFF8B64D713" modified="2009-03-03" version="1">MKEIKLPILPTTSVGSFPKPDYLVKARNQYSRGLIPYSTLHELELKATEEVIKLQEEIGIDILVHGEMERGDMATYFAENLEGFTISGLVRSYGNRYYKKPIVIGKIRRPKPITVEMFKYAQSLTKKPVKGMLTGPYTIADWSFNEYYDNKRDLVLDLAEVINQEALDLEKAGALFVQIDEPAVPTHPEEIEIAKEAFKITTRGLRSFLITHICYGDFRPIWKEVVNFPVHQFDLEFTNNADKLYPLIEKEGFPEEKYVAVGVIDVHSHRIETVDEIKARIKEALKHFSPEQVFIDPDCGLKTRTWEEAKAKLENMVKAVMEVREELIKQGYPSEITIRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0M6</accession>
    <name>B8E0M6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAP dicarboxylate transporter-DctP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584121.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353660.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1774"/>
    <dbReference type="EnsemblBacteria" id="ACK43046">
        <property type="protein sequence ID" value="ACK43046"/>
        <property type="gene ID" value="Dtur_1774"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1774"/>
    <dbReference type="eggNOG" id="COG1638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036176_4_1_0"/>
    <dbReference type="InParanoid" id="B8E0M6"/>
    <dbReference type="OMA" id="RHYEVCK"/>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004682">
        <property type="entry name" value="TRAP_DctP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006470">
        <property type="entry name" value="DctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="331" mass="38142" checksum="F504B8E2EBCC51FF" modified="2009-03-03" version="1">MKSFKRFLMLASLIILLFAVPLSAQTRQFVLKFNHVLSPLDPYHEGFLKWAKAVEERTKGGLKIEVYHSAQLGVEEDILEQIRQGANVGQNTDAARMAMYLPEIGVMNCPYFVDSPEEVAKLKKMPTVHNWLKTLEEKYGFKVLSFTWIQGFRHFMTNKPIKKPEDLKGLRIRTPGTPVWQESIRALGATPVALAFGDVYPALQQKAIDGVELVYNNIPGMRLYEVLKYVNETRHILLINFEVVSAKWFRSLPPTYQKILEEECDKAGLETTKVVFQREEEVKKLIQEKGMVIVPTKDIDLEAFKKAGEKAYEVLKVKEVKDRIWKELRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0M7</accession>
    <name>B8E0M7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584122.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353661.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1775"/>
    <dbReference type="EnsemblBacteria" id="ACK43047">
        <property type="protein sequence ID" value="ACK43047"/>
        <property type="gene ID" value="Dtur_1775"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1775"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1827"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_0"/>
    <dbReference type="InParanoid" id="B8E0M7"/>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="13"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="114"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="318" mass="35900" checksum="39A301D9B880F634" modified="2009-03-03" version="1">MFLFKVLITPRSFEKVKDRFEEIFRKEEIEVIINPLGRVLTEEEMKELVKDLDGLIVGIDPVTSEVLKNANKLKVISKYGVGVDNIDLEESKRRNIVVTNTPGVNSNAVAELTVGLIINVLRKINLSDKKTRGGNWNRFIGNELSEKTLGVIGTGSIGKRVVELLRGFNLRVLCFDKYPDYEWASREKIFYVTLQELLEKSDVITIHVPLTNETYHMISERELNMLKRNAVIINTSRGGIIDEEALYKFLKEGRILGAGLDVFENEPPINSPLLKLDNVVVTSHIGAHTEEAVINMARIAVENLVLALKGKEPLYRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0P9</accession>
    <name>B8E0P9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Septum formation initiator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584143.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353683.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1797"/>
    <dbReference type="EnsemblBacteria" id="ACK43069">
        <property type="protein sequence ID" value="ACK43069"/>
        <property type="gene ID" value="Dtur_1797"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1797"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2092930_0_0_0"/>
    <dbReference type="OMA" id="SPSIYNG"/>
    <dbReference type="OrthoDB" id="2063332at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="117" mass="14333" checksum="62A3B55C6A7F99C4" modified="2009-03-03" version="1">MAWQEYIKKKQKCKIDPYKIMFFFFLLYLSPSIYNGVKDYIEYTKKLKELLERKTKLEKEVKELREIAYHMNDPYIIEKIAREKLFMGRPGEEPILIIEKNTEDKKLKIDFLNLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0T4</accession>
    <name>B8E0T4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1397</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583749.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353285.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1397"/>
    <dbReference type="EnsemblBacteria" id="ACK42671">
        <property type="protein sequence ID" value="ACK42671"/>
        <property type="gene ID" value="Dtur_1397"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1397"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1444"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_0"/>
    <dbReference type="InParanoid" id="B8E0T4"/>
    <dbReference type="OMA" id="YQDTNRT"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033202">
        <property type="term" value="C:DNA helicase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="285"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="625" mass="73112" checksum="AC1BC606CF3D1FFB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0U0</accession>
    <name>B8E0U0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583755.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353291.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1403"/>
    <dbReference type="EnsemblBacteria" id="ACK42677">
        <property type="protein sequence ID" value="ACK42677"/>
        <property type="gene ID" value="Dtur_1403"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1403"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1037200_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0U0"/>
    <dbReference type="OMA" id="EDNIPYG"/>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="268" mass="31270" checksum="A2347BAF286CAFC5" modified="2009-03-03" version="1">MHRKIIDGKNKNIWRIILFLLFLTIILWSAGYLESIAFRIQYSFNRFFYNLQRTFDDIKSYITMTESLQKEIAELQTEILSLYKENQNLKLILENIKKREDYIPWLKDLADKNIEIIYADIVGRDPIKWNLELKVNKGYLDKVKVGMPVLYKDQVVGRVVRTEKHYSIVRTIYDPNFVLGVTVLETKDQGILRGGYDHMEMAYLFSDHGIKEGNTIITSGTEDNIPYGLKIGYIADLKEKAIFSFSNMKILPFEDISNIEGVAICVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Y6</accession>
    <name>B8E0Y6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583801.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353337.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1449"/>
    <dbReference type="EnsemblBacteria" id="ACK42723">
        <property type="protein sequence ID" value="ACK42723"/>
        <property type="gene ID" value="Dtur_1449"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1449"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771237_0_0_0"/>
    <dbReference type="OMA" id="RREHGYC"/>
    <dbReference type="OrthoDB" id="1454169at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="353" mass="41140" checksum="F8C52E57938A0255" modified="2009-03-03" version="1">MELFYPRVDHLFRLTDDTGILQHSKFGVPDPRFGYTTDDNSRALIVAIMLYKNYHEKRYLDLIYKYSSFLLNAQTDKGNFRNFMSYERRFLEEEGSEDCFGRTLWGLGFGIASKEIPIGVRNLHRELFIKALKYIENLRSPRSKAYTILGLYYAQKDLSLSSLKLIDYIDQLAKSLVRQFRENNDSSWRWFEDIMAYSNAILPLSLLVAYKVLKNENFKEVAIDSMEFLEGIVFRYGYFKPIGCNGWYVRGGKIAEFDEQPIEASEMILLYREAYEQFKDVKYINKAKETFMWFHGRNSKGVSMIDVESGGCFDGINEYGVNLNQGAESILSYLISYLTIKEIVNLKEEIAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E128</accession>
    <name>B8E128_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3D domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1491</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583843.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353379.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1491"/>
    <dbReference type="EnsemblBacteria" id="ACK42765">
        <property type="protein sequence ID" value="ACK42765"/>
        <property type="gene ID" value="Dtur_1491"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1491"/>
    <dbReference type="eggNOG" id="COG3583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036884_0_0_0"/>
    <dbReference type="InParanoid" id="B8E128"/>
    <dbReference type="OMA" id="ATAYEPW"/>
    <dbReference type="OrthoDB" id="2027419at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010611">
        <property type="entry name" value="3D_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06725">
        <property type="entry name" value="3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="G5" evidence="2">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="285" mass="32675" checksum="6A0A243023CC7CB8" modified="2009-03-03" version="1">MKKTKKRIISVTVFFGSLVIIASAKIIETNLWRNFTHLRPIKEVIIVDGNKRPIKVKTNAGFVWEVLEEKKIKVSKFDIVSPPARTPLTERIKEIRITRVNETTIKKINIIEPKIILKVTYAKTYTEKIKDYGRFGKIEEIYKRRTINGKPEKEVLISKKELQKMSPKIIEITTPILKYLKLDSATFEVVKPIKVTATAYEPWTGGDGNNITAIGWRAMKGIIAVDPRYIPLKSAFYIPNYGFALAGDTGGLIKGWKVDLCFSTLREVKYFGRRKITIYLLKRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E159</accession>
    <name>B8E159_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583271.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352801.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8E159"/>
    <dbReference type="STRING" id="515635.Dtur_0906"/>
    <dbReference type="EnsemblBacteria" id="ACK42187">
        <property type="protein sequence ID" value="ACK42187"/>
        <property type="gene ID" value="Dtur_0906"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0906"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.943"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_0_1_0"/>
    <dbReference type="InParanoid" id="B8E159"/>
    <dbReference type="OMA" id="YNNAVQA"/>
    <dbReference type="OrthoDB" id="1573349at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="183" mass="20951" checksum="0473491EFD4909BB" modified="2009-03-03" version="1">MIGLVILGVIVFIVVFVIVIYNRLVVLRNRVENAWAQIDVQLKKRYDLIPNLVETVKAYASHEKEVFEKIAMYRAQMVGAKTPGEAAQANEGLTSVLKTLFAIAENYPELKANQNFMMLQEELSGIESKIAYARQFYNDVVMMYNQSLQVFPNSIIANLFGFKPKEYFEVESPEERRAVKVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E169</accession>
    <name>B8E169_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase (Ubiquinone) 24 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0916</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583281.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352811.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0916"/>
    <dbReference type="EnsemblBacteria" id="ACK42197">
        <property type="protein sequence ID" value="ACK42197"/>
        <property type="gene ID" value="Dtur_0916"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0916"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_0"/>
    <dbReference type="InParanoid" id="B8E169"/>
    <dbReference type="OMA" id="CHVQGAE"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028431">
        <property type="entry name" value="NADP_DH_HndA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43342:SF2">
        <property type="entry name" value="PTHR43342:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="162" mass="18334" checksum="813351AC40306700" modified="2009-03-03" version="1">MAVELKFSDYAQRELEKILDQFSSTKGSLIMILHAIQEKFGYLPKEALEMVSEKLKIPLSEIYGVVTFYSFFRLEPQGKHVIRLCMGTACYVKGAADLLTALEQIGLKEGKVTEDGYFSLDLVRCIGACSMAPALMIDEEVYGKLTPDKLKKLIENFRKEHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E171</accession>
    <name>B8E171_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NADP-reducing hydrogenase, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0918</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583283.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352813.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0918"/>
    <dbReference type="EnsemblBacteria" id="ACK42199">
        <property type="protein sequence ID" value="ACK42199"/>
        <property type="gene ID" value="Dtur_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0918"/>
    <dbReference type="eggNOG" id="COG3411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126515_4_0_0"/>
    <dbReference type="InParanoid" id="B8E171"/>
    <dbReference type="OMA" id="TQTGCMG"/>
    <dbReference type="OrthoDB" id="1412344at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="123" mass="13439" checksum="D03FE916FD4E566F" modified="2009-03-03" version="1">MSKKLTIEDLKKIKEKAQADLEARSAEGKDKIVVHMGTCGIAAGARETLLAILDEIEKRNLKNVVVTQAGCIGLCEYEPLISVEKVGSSKVLYKHVTPEKARKIIAQHIVNGQIVTEDVLSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1A0</accession>
    <name>B8E1A0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SMC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583312.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352842.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0947"/>
    <dbReference type="EnsemblBacteria" id="ACK42228">
        <property type="protein sequence ID" value="ACK42228"/>
        <property type="gene ID" value="Dtur_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0947"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.984"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1A0"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="3">
        <location>
            <begin position="475"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="168"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="395"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="623"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1082" mass="128002" checksum="F3C572BDAEFADC6B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1E7</accession>
    <name>RS8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsH</name>
        <name type="ordered locus">Dtur_0995</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583359.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352889.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1E7"/>
    <dbReference type="SMR" id="B8E1E7"/>
    <dbReference type="STRING" id="515635.Dtur_0995"/>
    <dbReference type="EnsemblBacteria" id="ACK42275">
        <property type="protein sequence ID" value="ACK42275"/>
        <property type="gene ID" value="Dtur_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0995"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1032"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1E7"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000140546" description="30S ribosomal protein S8">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="131" mass="14979" checksum="F5960EF66EED9DEC" modified="2009-03-03" version="1">MTVTDPIADMLVRIKNANMRRHPTVDVPYSKMKEKIIEILLREGYIAKYEVIGEIPQKYIRVYLKYKGKTPVIQDVKRVSKPGRRYYVNKEEIPRVLGGLGIAILSTSKGIMTDKEARLLGIGGELICMVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1F0</accession>
    <name>B8E1F0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="11" type="ordered locus">Dtur_0998</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583362.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352892.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0998"/>
    <dbReference type="EnsemblBacteria" id="ACK42278">
        <property type="protein sequence ID" value="ACK42278"/>
        <property type="gene ID" value="Dtur_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0998"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1035"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_0"/>
    <dbReference type="InParanoid" id="B8E1F0"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="10">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="176" mass="18469" checksum="6409F6C0E72461C1" modified="2009-03-03" version="1">MKELEPVLKERVIEIRRVAKVVAGGKNLRFRALVVVGDEQGTVGVGIAKAAEVPDAIRKAIRKAKKNAVKVSISKGTIPHEVVGKLGASKILLKPAAPGTGVIAGGAARAVLELAGIKNVLAKALGSTTAVNLAQATFEALKKLRSLPEVAEMRDKRINEIIGLKTESKGNEEGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1H1</accession>
    <name>B8E1H1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582581.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352110.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0165"/>
    <dbReference type="EnsemblBacteria" id="ACK41496">
        <property type="protein sequence ID" value="ACK41496"/>
        <property type="gene ID" value="Dtur_0165"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0165"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.171"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010993_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1H1"/>
    <dbReference type="OMA" id="FMHSRVG"/>
    <dbReference type="OrthoDB" id="312576at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1006" mass="118348" checksum="2A80E8228CB475C9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1H8</accession>
    <name>B8E1H8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Coagulation factor 5/8 type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0172</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582588.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352117.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0172"/>
    <dbReference type="CAZy" id="CBM32">
        <property type="family name" value="Carbohydrate-Binding Module Family 32"/>
    </dbReference>
    <dbReference type="CAZy" id="GH28">
        <property type="family name" value="Glycoside Hydrolase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41503">
        <property type="protein sequence ID" value="ACK41503"/>
        <property type="gene ID" value="Dtur_0172"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0172"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.178"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401567_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1H8"/>
    <dbReference type="OMA" id="SDMARFF"/>
    <dbReference type="OrthoDB" id="593041at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="5">
        <location>
            <begin position="536"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="685" mass="77521" checksum="18B9A79016B86542" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1J1</accession>
    <name>B8E1J1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582601.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352130.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0187"/>
    <dbReference type="EnsemblBacteria" id="ACK41516">
        <property type="protein sequence ID" value="ACK41516"/>
        <property type="gene ID" value="Dtur_0187"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0187"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.193"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046126_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1J1"/>
    <dbReference type="OMA" id="TCLWYIR"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="2">
        <location>
            <begin position="213"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="439" mass="49346" checksum="93466D089A8F4DB0" modified="2009-03-03" version="1">MWGEDKILSFLKNILDKIPFERKEVSLAINNQELTRFANNIIHQNVAEENLSLTIRAGEGKRKIIINTSDLDIEKIDKLIKDLDELLKAQPETEELYLPEPEPIPSHEKKLINPSPELRANLVKIFTEKGEKHNLETFGALSENISEFGIMNSKGVKAYTVYSYAHGKVMYMGDGSGYQEEIGKNLNNINFEELSERALQKCIDSKNPEEIDPGSYTVILEPLAVGELLEMLSYFGFSAKAVQEKRSFLNLYMGQKIFKDFINIFDDGLNPEGIVIPIDFEGVPKKRVDLIKNGIPMGPVYDTATAVKEEKKSTGHALPPPSWGPAPLNLFFAPGEKSLEEIISETERGILVTRFHYVNAFLDPIRVLATGMTRDGTFLIENGKIKKPLKNLRFTQSFVEALTNVVEISKEAILVPSMGFSKVPAIKVENFNFTGKTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1J3</accession>
    <name>B8E1J3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582603.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352132.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0189"/>
    <dbReference type="EnsemblBacteria" id="ACK41518">
        <property type="protein sequence ID" value="ACK41518"/>
        <property type="gene ID" value="Dtur_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0189"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1J3"/>
    <dbReference type="OMA" id="DKNHTNY"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="6"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="333"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="448" mass="48889" checksum="67DD4A81F88CD0A6" modified="2009-03-03" version="1">MEKRTDVLIIGGGPAGIVCASTAKNYYPDKKITVLRSVQNSVVPCGIPYMFYSLKKPEDNKMGYAGLESAGIEVLVDEAVSINRKEKYVETKSGTKYYYEKLVLATGSLPIIPKITGIEKKNIFSIYKNLDYLKDVVEKVKESKNVLILGGGFIGVEIADEISKLEGINVYLVEMLPHLLAQSFDKEFSVLVEEKLRSKGVNVLTNAKVIEFIGDEKVRRVKLEDGREIDVDVVLLGIGARPNSELAKNTGLEVISTGAIWVDEYMRTSDPDIFAIGDCALKRDFYTRRNTAVMLASTATAEARIAGANLYKIKLIRENKGTIAVYSTYVDGLVLASAGLTESNAVREGFEIVTGTFEGIDKHPGTLPGVNKTKVKLIFSKHSGVLLGGQIAGGMSFAELINLIGVAIQQRMTASELETLQMATHPYLTCAPTVYHVVMAAQEAISKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1M3</accession>
    <name>B8E1M3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582633.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352162.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0219"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41548">
        <property type="protein sequence ID" value="ACK41548"/>
        <property type="gene ID" value="Dtur_0219"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0219"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_0"/>
    <dbReference type="InParanoid" id="B8E1M3"/>
    <dbReference type="OMA" id="VEPAYEF"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="582"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="749" mass="84878" checksum="6964B35F23EC9402" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1M7</accession>
    <name>B8E1M7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="8">3.5.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582637.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352166.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0223"/>
    <dbReference type="EnsemblBacteria" id="ACK41552">
        <property type="protein sequence ID" value="ACK41552"/>
        <property type="gene ID" value="Dtur_0223"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0223"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.232"/>
    <dbReference type="eggNOG" id="COG1820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032482_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1M7"/>
    <dbReference type="OMA" id="HAFNAMP"/>
    <dbReference type="OrthoDB" id="1026967at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047419">
        <property type="term" value="F:N-acetylgalactosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="PTHR11113:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="50"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="216"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="304"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="380" mass="42354" checksum="E873D36B947DCDF3" modified="2009-03-03" version="1">MGVNILGKIILKDRIFEDGVLKIENGKIVYIGEKKESKIDNIDYDFSDFYISPGFIDIHIHGAFGGDFLDCEYEEIEKIAIFLASKGVVGFLPTIVTAPIKDMREAVKKLEKYIRNQKNGGKALGIHLEGPFLNSKYKGAQPEEYIIKPDINILEKLYSPYLRVMTIAPEIDDEFKVIKYLKERNVIVSAGHTDASYDLMRDAALNGVSHITHLFNGMRPLHHREPGIVGYALVNDHVSVEVIADGYHLSDVILKMVVKLKPRYKVLLITDAIMATGLEDGEYRLSNQRVIVKNGRAVLESGSLAGSTLTMDKAIRNIIQMAGVNIIDAVYMASYSPARLLGLENRKGSIEVGKDADITVFDEGFNIKMTMVEGKKVFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1P0</accession>
    <name>B8E1P0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">von Willebrand factor type A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582650.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352179.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0236"/>
    <dbReference type="EnsemblBacteria" id="ACK41565">
        <property type="protein sequence ID" value="ACK41565"/>
        <property type="gene ID" value="Dtur_0236"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0236"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007196_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1P0"/>
    <dbReference type="OMA" id="VNYPLEY"/>
    <dbReference type="OrthoDB" id="525226at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="392"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="888" mass="100739" checksum="EC86BD9B7F969227" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1S1</accession>
    <name>B8E1S1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cell envelope-related transcriptional attenuator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582789.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352318.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0400"/>
    <dbReference type="EnsemblBacteria" id="ACK41704">
        <property type="protein sequence ID" value="ACK41704"/>
        <property type="gene ID" value="Dtur_0400"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0400"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.420"/>
    <dbReference type="eggNOG" id="COG1316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016455_5_3_0"/>
    <dbReference type="InParanoid" id="B8E1S1"/>
    <dbReference type="OMA" id="QMKINAA"/>
    <dbReference type="OrthoDB" id="491753at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="77"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="308" mass="35359" checksum="F4706009AA0C3905" modified="2009-03-03" version="1">MKRWLKILIIGVLVLLIVIVAVGVGGYYYIQNSYNYNPSRNSSVLDKVELLDVAFNKVERINIAILGVDERKNDPGRSDTIIIASLDFKNKKVNILSIPRDTRAYIPNHGFTKINHAYAYGGVELSLRTLENLLNIPIHYYVKTNFQQFEKFIDAIGGIDIEVERRMYYRDSTDKFFVDLTPGVHHLNGKEALGYVRFRHDPMGDLGRVERQQKFLMALFKQMKEKINLINLPQYISLAGSIFETNASLMEAMVIASKFMDITEEDIHTFVMPGTPENINGISYVIPDEIRLKEILDQYFKINNVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1T3</accession>
    <name>B8E1T3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide-transporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0412</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582801.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352330.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0412"/>
    <dbReference type="EnsemblBacteria" id="ACK41716">
        <property type="protein sequence ID" value="ACK41716"/>
        <property type="gene ID" value="Dtur_0412"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0412"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.435"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_4_0_0"/>
    <dbReference type="InParanoid" id="B8E1T3"/>
    <dbReference type="OMA" id="LAVWMDT"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="328" mass="34861" checksum="132590345132997B" modified="2009-03-03" version="1">MVGKLSILFSKSGLRQILMFASLFLLFVFFSLASPNFLTYENIIAILLATCVNGLLALGVTFVIITGGIDLSIGTVMTISAVMTGVFITFWRIPVFIGVLGGILTGVLAGFINGTVISKMKLPPFIATLGMMMIAKGLALVVSGCRPIYFNDTPIFNKIAMGSILGRIFPGLGDFPNAILWFVLFIIIAHILLTRTALGRYTFAIGSNEEAARLSGLNVDKWKTIIYSLCGMFVGIAGVIMASRLNSAQPALGQGYELDAIAAVVIGGTSLRGGEGSVIGTVIGALIMSTLTNGLRILSVPQEWQIVVSGIIVIGAVYLDIIRRSREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1U0</accession>
    <name>B8E1U0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transketolase central region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582808.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352337.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0419"/>
    <dbReference type="EnsemblBacteria" id="ACK41723">
        <property type="protein sequence ID" value="ACK41723"/>
        <property type="gene ID" value="Dtur_0419"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0419"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1U0"/>
    <dbReference type="OMA" id="PMHRNLG"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="3">
        <location>
            <begin position="461"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="791" mass="88640" checksum="ED247474E9D1C4E5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1U6</accession>
    <name>B8E1U6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-rhamnose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582814.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352343.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8E1U6"/>
    <dbReference type="STRING" id="515635.Dtur_0427"/>
    <dbReference type="EnsemblBacteria" id="ACK41729">
        <property type="protein sequence ID" value="ACK41729"/>
        <property type="gene ID" value="Dtur_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0427"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.451"/>
    <dbReference type="eggNOG" id="COG4952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059875_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1U6"/>
    <dbReference type="OMA" id="MIDQSHN"/>
    <dbReference type="OrthoDB" id="283831at2"/>
    <dbReference type="BRENDA" id="5.3.1.14">
        <property type="organism ID" value="13721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008740">
        <property type="term" value="F:L-rhamnose isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019324">
        <property type="term" value="P:L-lyxose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013457">
        <property type="entry name" value="Rhamnose_iso-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02635">
        <property type="entry name" value="RhaI_grampos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="84"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="397" mass="45873" checksum="CCEF5DA6D0099B12" modified="2009-03-03" version="1">MKNYEKRYEILRGMLEEEGINVDEVEKKLKNFRIETPSWGYGDSGTRFAVFKQKGSARNIKEKLQDAAIVHKLTGICPTVALHIPWDMYDDWDELLKYAESLGVKPGAINPNLFQDDDYKLGSLTHPDKRVREKAIKHILDCIEIAKKLGSRDISLWLADGTNHPGQDDFRFRKHRLEESLKEVYSHLEPDMRLLIEYKFFEPAFYHTDIPDWGTAIILSKKLGDKAYVLVDLGHHPLGTNIEQIVAILLDEGKLGGFHFNNKKYADDDLTTGSINPYELFLIFNELVSAEQDGLKMDIAYMIDESHNLKNKIEEMIQSVENIFRTYAKALIVNRKALRRYQEEQDIVMAENTLVKAFETDVMPLIYKVREEIGVPLDPLKAFRESGYMEKVIKERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Y3</accession>
    <name>B8E1Y3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582851.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352380.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0466"/>
    <dbReference type="EnsemblBacteria" id="ACK41766">
        <property type="protein sequence ID" value="ACK41766"/>
        <property type="gene ID" value="Dtur_0466"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0466"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.492"/>
    <dbReference type="eggNOG" id="ENOG5033A90">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_198854_4_1_0"/>
    <dbReference type="OMA" id="INMENIY"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024419">
        <property type="entry name" value="YvrJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12841">
        <property type="entry name" value="YvrJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="52" mass="5697" checksum="A2C725B5A260DAB6" modified="2009-03-03" version="1">MTDITQLISNLGFPIVVSLILLIRIETRLENLTKAINELSQAILNLSGKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Y5</accession>
    <name>B8E1Y5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582853.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352382.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0468"/>
    <dbReference type="EnsemblBacteria" id="ACK41768">
        <property type="protein sequence ID" value="ACK41768"/>
        <property type="gene ID" value="Dtur_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0468"/>
    <dbReference type="HOGENOM" id="CLU_2648684_0_0_0"/>
    <dbReference type="OMA" id="MEHREDK"/>
    <dbReference type="OrthoDB" id="2143593at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="76" mass="9014" checksum="357189BA85CA6D64" modified="2009-03-03" version="1">MLESIIKKVQFKFSFLYQAFPAYTCKICGKKKNFIFFIDENPICPECFPTFLEKQFLPLLISKIILSMEHREDKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Y8</accession>
    <name>B8E1Y8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582856.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352385.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0471"/>
    <dbReference type="EnsemblBacteria" id="ACK41771">
        <property type="protein sequence ID" value="ACK41771"/>
        <property type="gene ID" value="Dtur_0471"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0471"/>
    <dbReference type="eggNOG" id="COG5316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_735153_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1Y8"/>
    <dbReference type="OMA" id="VWEYISG"/>
    <dbReference type="OrthoDB" id="541612at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="373" mass="42683" checksum="77E3E4005CAB6354" modified="2009-03-03" version="1">MKYKLFILIFLIFIITTVFSQTSLVVYQQNIGVFSFDKEVELKKGLNFVSLEEVGGSVSYNNLFVLSTFGNTIREIVYPSLGVWIEAKEDTKDILKIYIIVPNIKWSSNHMFLIDGNKIRFFTEVIIQNSSDMNFQKVKMALLLGSLSMERDSYGVSKMSPLLAEATPSLPEVESIEGYKLFEIPGEWSISRGAIKLIPLIDTVVEDPIKRYVLGYMGNMKNVYILWNIENKKEKGLGIPIPSGKVNIFTMENGRVVFLGSANISDVSEGEKIEVVQGQDFDLTSERRILEEKKRIEGKYEITERSVSIIIKNAKKEKVLVEVWEYISGDEIEIKSSNFRYEKIDKNNFRFYVEVEPGKSAVLNYTCSIRNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Z1</accession>
    <name>B8E1Z1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582859.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352388.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0474"/>
    <dbReference type="EnsemblBacteria" id="ACK41774">
        <property type="protein sequence ID" value="ACK41774"/>
        <property type="gene ID" value="Dtur_0474"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0474"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650092_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1Z1"/>
    <dbReference type="OMA" id="SEYFVDY"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="230"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="422" mass="48967" checksum="16DC9BB630EBAB14" modified="2009-03-03" version="1">MRKISKLIAFLVILLLLLSSIRSDVRGDYALMVIRELSGVEYKGRQAGTFENLRALKFIERELKKLGLKDVFYQEFPVEVFYYDGAPELVLKGKGKVLKKYIYRKDFRDRFSGSYDLEAEIKNNLKDIKGTFYFVKDRYADKYILLAHAYGAKGVILGLPEDRAEIILQKSMFFLKEDLPVIYITPEVFDEISNYMHSEGRLKAYYRIKYKKEMAKAFNLYFFIPSLTKTEKTIVITAHVDHVGEDYDGSYFPGANDNASGVGVLLEIAKEIWERGNFSPYNLLFLVTNGEEKGLLGSEYFVDYPPIPMDNIVLNINFDCVGKGENLIISYNTYASKLVSNLRFTNNNLYFVREYYLNESDQYAFHLYEKPFLFFIAIDKNEDIPDLHKKTDTVDKISKNMLSFTINTFFEILDILSHNSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E207</accession>
    <name>B8E207_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582875.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352404.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0497"/>
    <dbReference type="EnsemblBacteria" id="ACK41790">
        <property type="protein sequence ID" value="ACK41790"/>
        <property type="gene ID" value="Dtur_0497"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0497"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.526"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_0"/>
    <dbReference type="InParanoid" id="B8E207"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="198"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="220"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="389" mass="45550" checksum="293793B01B90D538" modified="2009-03-03" version="1">MDRNFYTFYSPLQSEEEFRILKDLSEDLSYVIYSLRVREEKEKINKAYETIFKISPIGLIEVDLSEIKNFMKELLNEKLDFPSEEEFLQFFEEFMKKLRIIRMNEEVYKIFEIEDRTDAEKNRVGFIKNNLEILKENLFYISLPPLLYEREITIYTLKKNKKTLKIRAVPFPGCEEEPSHVILVIMDITEEKESIQKINRLLNQVVETLAEIVEKRDPYTAGHQKRVAKLAFFIGKEMGLSEEKLKGLYMAGLLHDIGKIAVPTDILNKPGKLDPIEFELIKKHPEVGYEILKNIEFPYPVAEIVLEHHERINGSGYPKGLKDGDILIEARILAVSDVVEAMSSHRPYRPAFPLETALREISEKKGILYDEEVVDACIKLFKEKNFRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E269</accession>
    <name>B8E269_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase FAD/NAD(P)-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="2">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 1 FAD per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583429.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352960.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1067"/>
    <dbReference type="EnsemblBacteria" id="ACK42346">
        <property type="protein sequence ID" value="ACK42346"/>
        <property type="gene ID" value="Dtur_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1067"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1103"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_0_0"/>
    <dbReference type="InParanoid" id="B8E269"/>
    <dbReference type="OMA" id="AGQFIIL"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="283" mass="31096" checksum="E35102BA010E82E2" modified="2009-03-03" version="1">MFEIIVKKELAPNVKLIEVKAPLIARKALPGQFVILRVYEKGERIPLTIAEKNIETESITIVFQEVGKTTKLLGKLRVGDKISDIVGPLGNPSEIERFGVVIGVGGGVGIAALYPILKGLKEKGNYVISIIGGRSANYVIFREEIEKISDEIYVTTDDGSLGRKGLVTDVLKEILEKRKIDRIWAVGPTIMMKVVSDLTKAYHVPTIVSLNPIMVDGTGMCGGCRVTVGGKIRFTCVDGPEFDGHLVDFDELLTRLKTYKDEETLALRLFEESEGEKVGYSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E271</accession>
    <name>B8E271_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583431.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352962.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1069"/>
    <dbReference type="EnsemblBacteria" id="ACK42348">
        <property type="protein sequence ID" value="ACK42348"/>
        <property type="gene ID" value="Dtur_1069"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1069"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1105"/>
    <dbReference type="eggNOG" id="COG1937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130332_1_1_0"/>
    <dbReference type="InParanoid" id="B8E271"/>
    <dbReference type="OMA" id="TYCDDVL"/>
    <dbReference type="OrthoDB" id="1868412at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="81" mass="9265" checksum="EE888369136FA43C" modified="2009-03-03" version="1">MDKKEYLVALRRIEGQVRGLQRMIEEERDCKEIISQIAAVRSALKRVGILIVEEYAKKCIIGGENAESEISELLKDLQSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E273</accession>
    <name>B8E273_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583433.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352964.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1071"/>
    <dbReference type="EnsemblBacteria" id="ACK42350">
        <property type="protein sequence ID" value="ACK42350"/>
        <property type="gene ID" value="Dtur_1071"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1071"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1107"/>
    <dbReference type="eggNOG" id="COG2509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046973_1_0_0"/>
    <dbReference type="InParanoid" id="B8E273"/>
    <dbReference type="OMA" id="KVRTFCM"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIDA" evidence="1">
        <location>
            <begin position="367"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="469" mass="51985" checksum="924D6D14DB5505F7" modified="2009-03-03" version="1">MRYDVIIIGGGPAGIFSAISLVRGKKPLKILLVEKGELTSKRVCPAIVNRQGCVRCPRCNIVSGWGGAGAFSDGKLTFSTEVGGWLKDYIGEEKLLKLMEEVNNIYTEFGADQPVIKPDPEKFAYFQRKAIAADLRLVYFAVRHLGTEKCAPILLNMYEYLKDKIDIILGKQVSKILVENGKVKGVELEDGKIYYADYVIVGPGREGAKWFSGEGQRIGLSWVINPVDIGVRVEIPAAVMKELTDELYEAKFIYYTKTFDDKVRTFCMNPYGEVVMEQNEGIISVNGHSFAEKKTENTNFAILVSKNFTEPFRDPIAYGRAIGSLANLLSNGVILQRLGDLLAGRRSTWDRLQKGMVVPTLKDAVPGDLSLVLPYRYLVDIIEMIQALDKVTPGIYSRHTLLYGVEVKFYSARVKLNSSLETEIKNLFAIGDGAGITRGLMQASASGLLVGQEILKRMALLSDISEVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E289</accession>
    <name>B8E289_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Trigger factor</fullName>
            <shortName evidence="9">TF</shortName>
            <ecNumber evidence="3 9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tig</name>
        <name evidence="13" type="ordered locus">Dtur_1087</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="9">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583449.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352980.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1087"/>
    <dbReference type="EnsemblBacteria" id="ACK42366">
        <property type="protein sequence ID" value="ACK42366"/>
        <property type="gene ID" value="Dtur_1087"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1087"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1123"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033058_3_1_0"/>
    <dbReference type="InParanoid" id="B8E289"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="Trigger_N" evidence="11">
        <location>
            <begin position="10"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="10">
        <location>
            <begin position="186"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Trigger_C" evidence="12">
        <location>
            <begin position="263"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="431" mass="50963" checksum="7ABC25E0C650D191" modified="2009-03-03" version="1">MPINESSVKYDIEKLQGSRIKVNVEVDAREREESLERAYKSLVKRYQVPGFRKGYTPRPVLERYLGIEAFEDEAIRIVAREVLNMILQNENFTPLQDPYFDLLPQEWKENENLKFSFVIEVPPEFKLGDYKGFGLKKEKVEVSEEEINRVIEQIELQLSKLNTVEEGSIEKGDVVYLEREREDGSQLPPLWFTLNGQMLPELEEKLIGMKPGEEKVIEISFPEDFYEKELAGQSLPLKWKVKKIWRYEKPDQEIFLQKVNASSIEEFREKVRESIKEEREKLEEDKLFSQILDKILENTELDPPLSYVHYLAENILREFLTELNKKGVQLEDYLSQRGISKDEFVNNVIEDARKRIKIEMILDKIAEIENINISDEEINNVIKEIAENEGKEFKEIKRELEREGTINTLKRNLLREKVREFLIKENVVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>B8E293</accession>
    <name>B8E293_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ion-translocating oxidoreductase complex subunit C</fullName>
            <ecNumber evidence="9">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Rnf electron transport complex subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnfC</name>
        <name evidence="12" type="ordered locus">Dtur_1091</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583453.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352984.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1091"/>
    <dbReference type="EnsemblBacteria" id="ACK42370">
        <property type="protein sequence ID" value="ACK42370"/>
        <property type="gene ID" value="Dtur_1091"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1091"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1127"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010808_6_0_0"/>
    <dbReference type="InParanoid" id="B8E293"/>
    <dbReference type="OMA" id="YPMGSEK"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00461">
        <property type="entry name" value="RsxC_RnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010208">
        <property type="entry name" value="Ion_transpt_RnfC/RsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026902">
        <property type="entry name" value="RnfC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43034">
        <property type="entry name" value="PTHR43034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13375">
        <property type="entry name" value="RnfC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01945">
        <property type="entry name" value="rnfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="356"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="437" mass="47741" checksum="73E80CEC1F052211" modified="2009-03-03" version="1">MKILSFKGGVHPPEKKELSKDSPISKLPLPERLIIFTWQHTGASNDPLVKVKDYVYKGQKIGDKQAYVSAPIHAPTSGTVKRIGLYPHPTGKQMVGIEIEPDGKDEVYPDLPPSVNWQNLSPEEIKSRIREAGIVGLGGAAFPTHVKISPPPEKKIDTVILNGAECEPYLTIDYRLMLEKPELIIEGLHILMYVLGVKRGIIGIEDNKKDAVEVLKKYADSDIEIVTLPTKYPQGSEKHLIKAVLGREVPSGGLPMDVGVVVNNVGTAVAIAEHFRTGLPLISRGVTVTGEGVNSSKNLEVLIGTPVIKLIEYVGGFKGKPGKILFGGPMMGVAIYDLNTPIVKGTSGVVVFPEDKVEYYDPIPCVRCGKCLEVCPMGLMPTTLARYVKKGKLVEAEELGILDCIECGSCNYICPSRRPLLQWIRVGKTDILARRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E296</accession>
    <name>B8E296_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ion-translocating oxidoreductase complex subunit E</fullName>
            <ecNumber evidence="7">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Rnf electron transport complex subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rnfE</name>
        <name evidence="8" type="ordered locus">Dtur_1094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583456.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352987.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1094"/>
    <dbReference type="EnsemblBacteria" id="ACK42373">
        <property type="protein sequence ID" value="ACK42373"/>
        <property type="gene ID" value="Dtur_1094"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1094"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1130"/>
    <dbReference type="eggNOG" id="COG4660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046659_1_1_0"/>
    <dbReference type="InParanoid" id="B8E296"/>
    <dbReference type="OMA" id="DGFMMGL"/>
    <dbReference type="OrthoDB" id="1782047at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00478">
        <property type="entry name" value="RsxE_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010968">
        <property type="entry name" value="RnfE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30586:SF0">
        <property type="entry name" value="PTHR30586:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01948">
        <property type="entry name" value="rnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="199" mass="21924" checksum="0F5D8BD43B2A10DF" modified="2009-03-03" version="1">MRNFFKYVVNGIFKENPVLILMIGLCSVLAVSTSVENAIGMGLAFSFVMIFSNLFVSLLRPITPNEIRIPIFIIVIGTFTTIVDLVISAYFPELYKALGIFIPLIVVNCIIIGRAEAFAYRHSVLESVADGIGISLGYIWAIVALGLIREFLGNGTILGKVIFSGFDPAKVFTMPPGAFWGIGLLIGLLKWFEKRVSRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2C5</accession>
    <name>HIS7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="1">IGPD</shortName>
            <ecNumber evidence="1">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisB</name>
        <name type="ordered locus">Dtur_1123</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583485.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353016.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2C5"/>
    <dbReference type="SMR" id="B8E2C5"/>
    <dbReference type="STRING" id="515635.Dtur_1123"/>
    <dbReference type="EnsemblBacteria" id="ACK42402">
        <property type="protein sequence ID" value="ACK42402"/>
        <property type="gene ID" value="Dtur_1123"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1123"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1160"/>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_2_1_0"/>
    <dbReference type="InParanoid" id="B8E2C5"/>
    <dbReference type="OMA" id="ARHGLFD"/>
    <dbReference type="OrthoDB" id="1278103at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000117083" description="Imidazoleglycerol-phosphate dehydratase">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <sequence length="186" mass="21094" checksum="B4F7028924D161CD" modified="2009-03-03" version="1">MRKSEIERETKETYVKILLNLDGSGSFLGDFPVPYYKHLFSAFCFYAEWDVEIMAKGDVEVDPHHLIEDTGIVWGKAFYSAVSNSNFLRFSSKIVPMDEALVMAVVDISGRPYLEIRDDKGILNGRLIKEFLRGFVNNSQITLHIWLLSGENLHHIEEAIFKALGLALGEASKEVPNLKSTKGKIW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2D8</accession>
    <name>RL28_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmB</name>
        <name type="ordered locus">Dtur_1508</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012547624.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353396.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2D8"/>
    <dbReference type="SMR" id="B8E2D8"/>
    <dbReference type="STRING" id="515635.Dtur_1508"/>
    <dbReference type="EnsemblBacteria" id="ACK42782">
        <property type="protein sequence ID" value="ACK42782"/>
        <property type="gene ID" value="Dtur_1508"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1508"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1557"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_0"/>
    <dbReference type="InParanoid" id="B8E2D8"/>
    <dbReference type="OMA" id="RINVCTS"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000121624" description="50S ribosomal protein L28">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <sequence length="63" mass="7180" checksum="47FA7BA191A35B76" modified="2009-03-03" version="1">MSRRCEICGKGPWTGLQVSHSHRRTKTRWLPNLHKVRALVNGKVKTIKVCTRCLKAGKVQKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2G5</accession>
    <name>B8E2G5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimM</name>
        <name evidence="5" type="ordered locus">Dtur_1535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583885.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353423.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1535"/>
    <dbReference type="EnsemblBacteria" id="ACK42809">
        <property type="protein sequence ID" value="ACK42809"/>
        <property type="gene ID" value="Dtur_1535"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1535"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1584"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_3_2_0"/>
    <dbReference type="InParanoid" id="B8E2G5"/>
    <dbReference type="OMA" id="DEFYHAD"/>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RimM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PRC" evidence="4">
        <location>
            <begin position="95"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="166" mass="19358" checksum="7740FB6D7FAF3865" modified="2009-03-03" version="1">MVRIAKLGEPFGIKGGIKIWPFFDLIDTLKKGQKIYLSWGDTLLVRRELSLENIREHNKGYVIYFSEIETREDAEKIRGNWLLIEEEDLPKLPEGQYYTYQIMGLSVYEESGEYLGKVKEILETGSNDVYIVEGEDEDIYIPAIKDVIVEINLDEGKIIIRKMEEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2G7</accession>
    <name>RS16_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsP</name>
        <name type="ordered locus">Dtur_1537</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583886.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353425.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2G7"/>
    <dbReference type="SMR" id="B8E2G7"/>
    <dbReference type="STRING" id="515635.Dtur_1537"/>
    <dbReference type="EnsemblBacteria" id="ACK42811">
        <property type="protein sequence ID" value="ACK42811"/>
        <property type="gene ID" value="Dtur_1537"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1537"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1586"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_2_0"/>
    <dbReference type="InParanoid" id="B8E2G7"/>
    <dbReference type="OMA" id="GFYNPIA"/>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000196392" description="30S ribosomal protein S16">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <sequence length="93" mass="10637" checksum="6585FA090BF97000" modified="2009-03-03" version="1">MVKIRLTRVGAKNKPAYRIVAMDSREPRDGKHLEILGFYDPKTDPATIQLKEERILYWLSQGAQPTDTVLSILKRYGVWDKFLAMKKSAKSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2J3</accession>
    <name>B8E2J3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="9">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">leuS</name>
        <name evidence="14" type="ordered locus">Dtur_1563</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583912.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353451.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1563"/>
    <dbReference type="EnsemblBacteria" id="ACK42837">
        <property type="protein sequence ID" value="ACK42837"/>
        <property type="gene ID" value="Dtur_1563"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1563"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1612"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2J3"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="12"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1_2" evidence="13">
        <location>
            <begin position="220"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1" evidence="11">
        <location>
            <begin position="415"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="12">
        <location>
            <begin position="652"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="581"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="810" mass="94758" checksum="D283C6A2F902121F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2K4</accession>
    <name>B8E2K4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ordered locus">Dtur_1574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583923.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353462.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1574"/>
    <dbReference type="EnsemblBacteria" id="ACK42848">
        <property type="protein sequence ID" value="ACK42848"/>
        <property type="gene ID" value="Dtur_1574"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1574"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1622"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2K4"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="52"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="431" mass="48512" checksum="3D9FCDF7C4F16700" modified="2009-03-03" version="1">MKILFKNITLVYPEKDKEEIGDLYIEDRIIKRIGKGLDINGNVEVIDGKDKIVVPTLVDIHVHLREPGYEWKETIESGSKAAVAGGFTAICCMPNTNPPIDNKEMVRFIYEKADIVGLSRVYPIGTITKGREGKEISEMGDMFMAGAKGFSDDGSCVMNSEVLRCALEYSKIFNAPIIEHAEDTNLTLEGNVNFGKISTLLGFKGMPWVAEASIVARDVFLSALTGGRLHIAHISCWQSLDMIKWGKEHGANITCEVTPHHLVLTEDAVKEMNYDTNTKMNPPLRTKEDQEALWEGIKNDLIDVIATDHAPHHLDDKMVEYGLAEYGISGLETAIPLVITYGYYERKIPLSKLFKKMSYNPCKILNLPYIPLEESVPANLTIIDLSEKEVEKEKFFSKGKNTPFHGWRLKGWPVMTFVEGRLVYREGKILW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2K6</accession>
    <name>B8E2K6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="6" type="ordered locus">Dtur_1576</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583925.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353464.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1576"/>
    <dbReference type="EnsemblBacteria" id="ACK42850">
        <property type="protein sequence ID" value="ACK42850"/>
        <property type="gene ID" value="Dtur_1576"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1576"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1624"/>
    <dbReference type="eggNOG" id="COG2065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094234_2_1_0"/>
    <dbReference type="InParanoid" id="B8E2K6"/>
    <dbReference type="OMA" id="PIQPDFC"/>
    <dbReference type="OrthoDB" id="1725260at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="183" mass="21035" checksum="05FDAC896F1881FE" modified="2009-03-03" version="1">MYFQEKAKIMDKEAIKRALRRIAHEIVERNKGISNVVLIGIRRRGVPLAQRLQQFLKEIEDIEVPVGSLDITLYRDDLNLRLEQPKVGKTEIDFPIENKDVILVDDVLYTGRTVRSALDALMDIGRPKTVQLAVLVDRGHRELPIRADYVGKNVPTSRKEQIEVRLEEIDGVDEVVIGEWKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2L3</accession>
    <name>B8E2L3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase FGGY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583932.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353471.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42857">
        <property type="protein sequence ID" value="ACK42857"/>
        <property type="gene ID" value="Dtur_1584"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1584"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_4_0"/>
    <dbReference type="InParanoid" id="B8E2L3"/>
    <dbReference type="OMA" id="GSQLREW"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="237"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="449" mass="52030" checksum="F689EF19A24825E6" modified="2009-03-03" version="1">MYITIDLGTTNIKIIIWSEEGKILKKESINTPIERDKTINPLRLINTIEEITEKFKRKYKNRITGISTGGMAESGLLIDKKGRPLTPVYTWLDHRGGEELKILKKLSRERIFEITGLKINPKYSLAKILWLKKHYKDLWRNSYKWLNVIDFINYHFTGKPITDYSLASRMLLFDIRNKKWSEEILNLCEIPMEKLPEVKPAGSIIEEKEQIYVLGGHDHPIGSLTLDLSKTLYDSWGTAEAILAHTKEPMLIESIKELGYSVGCIWNNLYYVIAGIPYSGGITKWTKEKLKLSFKVKTEKSSKILFFPYLMGKENRNSKIIKAFFYGIDLNTSLKDIGQAIWEGVFFETKTIIESLKKNFEIKKIIVSGGMTRYKSLLQLKANIINMPLHISKEKELTSKGLALLISKALNKELENFKEKSFLTIYSQNKEEFEKVYFEYKKIRDLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2M1</accession>
    <name>B8E2M1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583940.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353479.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1592"/>
    <dbReference type="EnsemblBacteria" id="ACK42865">
        <property type="protein sequence ID" value="ACK42865"/>
        <property type="gene ID" value="Dtur_1592"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1592"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1642"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2M1"/>
    <dbReference type="OMA" id="STQMFPG"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="283" mass="32279" checksum="CB475B08522CAF8D" modified="2009-03-03" version="1">MNRRINRSLWGNMIVIIVLTVVAIFMALPLVYSIMNAFKPLDELFLFPPRLFVRRPTLKNFSDLFYLMSNSFVPFSRYLFNSVFISFLSTLGHVIIASMAAYPLAKHRFPGSKFLFNLVIFSLMFSGYVTNIPRFIIMAKLGLLDTYFALILPYIGATLGLFLMKQFMEQIPDSYIESARIDGANEFRIWWHVVMPNVKPAWLTLILFAFRDTWNDTYTPALYLHNEAMKPFSLALTYIQQGGFVRAGAAAAAAVLMMLPSLIIFILTQSNVVETMKSAGIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2P7</accession>
    <name>B8E2P7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NusG_II domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1618</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583966.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353505.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1618"/>
    <dbReference type="EnsemblBacteria" id="ACK42891">
        <property type="protein sequence ID" value="ACK42891"/>
        <property type="gene ID" value="Dtur_1618"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1618"/>
    <dbReference type="eggNOG" id="COG5341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130936_1_2_0"/>
    <dbReference type="InParanoid" id="B8E2P7"/>
    <dbReference type="OMA" id="MISSPCP"/>
    <dbReference type="OrthoDB" id="1864717at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038690">
        <property type="entry name" value="NusG_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024045">
        <property type="entry name" value="NusG_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07009">
        <property type="entry name" value="NusG_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="NusG_II" evidence="2">
        <location>
            <begin position="9"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="115" mass="13344" checksum="F059388CC119E0A5" modified="2009-03-03" version="1">MFRRYDILLIIFFLLLALGLFYFNYIRNEGVVLKVYVNNREVFSKSLGELKSRERFEVQGLLGKSVFEYVEGKGVRMISSPCPDKLCIKQGFINKVGESIVCLPNRVVITWEGRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E324</accession>
    <name>MURC_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murC</name>
        <name type="ordered locus">Dtur_1246</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583606.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353138.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E324"/>
    <dbReference type="SMR" id="B8E324"/>
    <dbReference type="STRING" id="515635.Dtur_1246"/>
    <dbReference type="EnsemblBacteria" id="ACK42524">
        <property type="protein sequence ID" value="ACK42524"/>
        <property type="gene ID" value="Dtur_1246"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1246"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1286"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_2_0"/>
    <dbReference type="InParanoid" id="B8E324"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000117410" description="UDP-N-acetylmuramate--L-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="111"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <sequence length="464" mass="51764" checksum="4F22A4DDC027EC4C" modified="2009-03-03" version="1">MLNAKRIHFIGIAGTGMSALAYICVERGYEVSGSDIQENISTIRLKSKGVKIYKGHNPENVNNVDLVVISSAIPPDNEEYVYAKERNIPILHRSDLLADLTKEKKSIIVGGAHGKTTTTSMIALVLENNKIDPTILVGGELEDIGGNAKLGNGEYLVAEGDESDGSILKLDPYILVITNIDNDHLDYYKSLEKIKDTFLKVIEKVPKGGFAVLNLDCENVRDIIRKIKNKEYYTYGFSNADFKADNIVLNLSGSEFDVYFRNEKLGRVKLRVPGKHNILNSLSAIAVSKILGLDFETTTKALERFQGVQRRIQLKGIIEDDILVFDDYGHHPTEIKATLETLRLYNRRLVVVFQPHRYTRTYFLSKEIAEALSLGDVIILTEIYSAGEKPIPGVSSKNIYDEIREKYPNLEVYLVDNIIEAASKAKSILKKGDLLLTLGAGNVWKVGEALLARGRKDANLEYSQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E328</accession>
    <name>MRAY_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="1">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraY</name>
        <name type="ordered locus">Dtur_1250</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583610.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353142.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E328"/>
    <dbReference type="SMR" id="B8E328"/>
    <dbReference type="STRING" id="515635.Dtur_1250"/>
    <dbReference type="EnsemblBacteria" id="ACK42528">
        <property type="protein sequence ID" value="ACK42528"/>
        <property type="gene ID" value="Dtur_1250"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1250"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1290"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_0_0"/>
    <dbReference type="InParanoid" id="B8E328"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000116511" description="Phospho-N-acetylmuramoyl-pentapeptide-transferase">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <sequence length="307" mass="35486" checksum="44CE2FD85A8A6B91" modified="2009-03-03" version="1">MNIILFTSLVAFFVFLLILKYWINFQKSKGIGKYIRKEGPSSHFQKSGTPVMGGIIFLIVSIPFLFFKETFFPSLSTILFGLLGLLDDFKLMVNKDYGIRPLRKIFLSFIITLLLYIFSFHDYKIYWGSKLIISSRIFYVILFFVVFIAVPNAINLTDGLDGLAGGTSLITLFFFLIYNFQFNNELTLEISLMITALIAFLWFNSHPAEIFMGDVGAFALGGFIASLSIINKVELLLVFLGGIFLIESLSVFIQVFFYKWKKRRVFLMSPLHHHFELKGWKETKVVWRFYIIHLIMMIGGIILWNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E331</accession>
    <name>B8E331_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583980.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353519.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1632"/>
    <dbReference type="EnsemblBacteria" id="ACK42905">
        <property type="protein sequence ID" value="ACK42905"/>
        <property type="gene ID" value="Dtur_1632"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1632"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_4_0"/>
    <dbReference type="InParanoid" id="B8E331"/>
    <dbReference type="OMA" id="AKAMWIK"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="9"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="383" mass="42394" checksum="2A702EA016BB81AC" modified="2009-03-03" version="1">MQYFNFYIPVRIKFGVGLWEKIPEESYSLGAKKILIVTGKKHLKSTGILARLINIYNNYPIDVYIFDEVPPEPPYYVVDQGAEIVKTKNIDLIVGIGGGSALDVAKAIAVKVNLPGTIWDYVGENSNKITMKGIPTILAPTTAGTASEVTRVSVLINPETKEKLSIRHDFLYATLAIIDPYLTLSLPKENTAYSGLDAFIHSLESFLSINSNMVTEPLALTALRTIYKYLPRVYNNLERIDLREKVLYASTISGIAFTQTGLGGIHALAHPIGAYANIPHGLACAIITIPVLEYNLEILTKEKISALGRALGVYSLRSAKERILKKIAELFSVLNIRLGLHNYGIKWQDLPNIAKEAPKTGSYKTNPRTLTYEVVLEILKKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E342</accession>
    <name>B8E342_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein/LacI transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583991.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353530.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1643"/>
    <dbReference type="EnsemblBacteria" id="ACK42916">
        <property type="protein sequence ID" value="ACK42916"/>
        <property type="gene ID" value="Dtur_1643"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1643"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_3_0"/>
    <dbReference type="InParanoid" id="B8E342"/>
    <dbReference type="OMA" id="QELNNEY"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="33"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="338" mass="36219" checksum="E1B555D1894B3C21" modified="2009-03-03" version="1">MRKVLVAILIILFPIIFSIGYSKEIHVAVIGKSVHPYWAEVELGVKQAAKDLGVKATFFVPQKEDIPAQISQMESFIAMGVDGIAIAPSDPTAIAPTIEKAMAKGIPVITLDTDAPQSKRLVYIGTDNYSAGKIAGMVMNDLLGIKGGKVAIGTGSLTAMNSLERIRGFMDGIASNKRIVVVTKPALCDFEDTGRAVTLAEQALLTYPDLRGFFGVYAFNGPAAAKAVKSAGKVGQVLIVCFDTTAEHMQLIKEGVISATVGQRPYMMGYKSVEVLTKMAQKGVDATLKELPANRIIDTGVDVVAGDKYVKSIKSVQALTVEQYRKKLQELGIPVQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E352</accession>
    <name>B8E352_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryldialkylphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="2">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584001.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353540.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1654"/>
    <dbReference type="EnsemblBacteria" id="ACK42926">
        <property type="protein sequence ID" value="ACK42926"/>
        <property type="gene ID" value="Dtur_1654"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1654"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1704"/>
    <dbReference type="eggNOG" id="COG1735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054760_1_0_0"/>
    <dbReference type="InParanoid" id="B8E352"/>
    <dbReference type="OMA" id="CHMNPSH"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009056">
        <property type="term" value="P:catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017947">
        <property type="entry name" value="AryldialkylPase_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001559">
        <property type="entry name" value="Phosphotriesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10819">
        <property type="entry name" value="PTHR10819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02126">
        <property type="entry name" value="PTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01322">
        <property type="entry name" value="PHOSPHOTRIESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51347">
        <property type="entry name" value="PHOSPHOTRIESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="2">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1 3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601559-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="311" mass="35610" checksum="B0D48D59CE3496F8" modified="2009-03-03" version="1">MVMTVKGFVDKKDMGKTLVHEHILVDFSPAEEQIKIDDNLRNEIVEIMLPYLMEIKNLGYSTFFECTPKYVGRDVKVLKILSEKTGLNVITNTGFYGAGEDKHVPKKYWNLSSEDFAKMWIEEWEKGIEDGIKPGFIKTAVNPGPLNEIDKKLIRASAFTHLETGLTVACHTGEERCALEVARIFEEEKVDLSALIIVHADAIENFEVHLELLEKGAFLEYDSIGARPMEYHLNLMEKVIKEGFIDRILISHDAGWFTVGKSKEEQNIRPYTDISYKFIPKLEEKGISEEIVEKLLVNNPSEAFDIRVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E363</accession>
    <name>B8E363_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584012.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353551.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1665"/>
    <dbReference type="EnsemblBacteria" id="ACK42937">
        <property type="protein sequence ID" value="ACK42937"/>
        <property type="gene ID" value="Dtur_1665"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1665"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587584_0_0_0"/>
    <dbReference type="OMA" id="YILWRFW"/>
    <dbReference type="OrthoDB" id="1143375at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="465" mass="54736" checksum="BFC3CC276BBEE6DB" modified="2009-03-03" version="1">MGIRGDLQSIPLWEVLQTLSIGRKTGKLEIDNGLKRVEVFFENGKIVNVKTGFIEGYNAVLGLVLWNIGDFVFYPEGKTQNKTLNLDPLEIIVNFSKHLDLMNYLSDFVLLPVRMDGLALEEEVVSSSFDGTAKVRDVVLNSPLGELKALELIQKLIREGKLLRVDDDERLFWIYILWRFWKFLMQEEGRRYLINERGLKKDIQSFVSKIHEDFSGLLEDLINSEKMSWHYFYRHLTRFDFNEVELAIRDVFDFLNKYVKSEIDKTKAEQFSVVLKGEGNDIFVPVCRDLRTDEFVVSLFFDGERTLRQVFDYSPLEKIYTQNVIANLIINNCLINVKSDYKIAMIYSFYIFWNTLKRELKEESLIKEIEKVWSEFVGSSLLDVRYLFNHIVLDRRPNFIYFYKEKDKYSEDEIKNFIVEAGGLIYSVLESKLSKSNKDEVFNKIIREIESKVVKEKEIYISLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3E8</accession>
    <name>B8E3E8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Auxin Efflux Carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584097.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353636.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1750"/>
    <dbReference type="EnsemblBacteria" id="ACK43022">
        <property type="protein sequence ID" value="ACK43022"/>
        <property type="gene ID" value="Dtur_1750"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1750"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1802"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_6_1_0"/>
    <dbReference type="InParanoid" id="B8E3E8"/>
    <dbReference type="OMA" id="HFSKFAF"/>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="296" mass="33329" checksum="946987B233D96E36" modified="2009-03-03" version="1">MAESILINVLVIIIGHIAKKIKLFPEDTGTVLSRLVIYITLPATVLKVFISSALKLDLFIVPLISFFFGLLIFLIGFLLLNNLELEDRLKWTLLIGICGYNVGLFSYPFIKSLYGDEGLLYMAMFDIGNSFIVFGLSYALSLVSEDGWSFNKTTHLLERVFSFFPLQVYIISILLSLLKVNFPEIFISLISQLSIPNSTLALFTLGYFLDFRLNKAEIRALIYGTLIRFIPGIIFSLVLRSIWHSLMVKIISIGVLLPAPLVVVIYSNEKGLNSKFASFYVSLTILLGIIFLVLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYG3</accession>
    <name>B8DYG3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582431.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351959.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0004"/>
    <dbReference type="EnsemblBacteria" id="ACK41345">
        <property type="protein sequence ID" value="ACK41345"/>
        <property type="gene ID" value="Dtur_0004"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0004"/>
    <dbReference type="eggNOG" id="COG3809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129203_0_0_0"/>
    <dbReference type="OMA" id="CFGMWLP"/>
    <dbReference type="OrthoDB" id="1847417at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="134" mass="15972" checksum="05691DFECCECEF19" modified="2009-03-03" version="1">MKPEEVEKFSIEKSIKSLCQPSICPNDKSPLMLLKDPLIPKDIVIYYCEQCFGMWLPLDSLRKYKAYQRSRKESFNKESRENLPKELEEKIDLLLKKGEEDLKKQNEFELDYKMSQFVSVVLLILKILSYFIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYG9</accession>
    <name>B8DYG9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582437.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351965.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0010"/>
    <dbReference type="EnsemblBacteria" id="ACK41351">
        <property type="protein sequence ID" value="ACK41351"/>
        <property type="gene ID" value="Dtur_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0010"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="InParanoid" id="B8DYG9"/>
    <dbReference type="OMA" id="RTRGQMW"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="339" mass="38801" checksum="7BD51A486F3012ED" modified="2009-03-03" version="1">MTTFNNISQTIDLSRSFFNKREKKIIEALKDVNLQITKGQILGILGRNGAGKTTLIRILTTLLLPTSGKAFVLGFDVEKEFNKIRSKINLVSGGENPGYGILTVRENLFFFSQLYGLNLREAKRKIDFYIKEFGLKERAESLLNTLSTGEKQRLQLMRGLINDPEVLFLDEPTVGLDVESARFIRNYVKEWVKEGNRTVILTTHYLSEVEELCKYIAIIDKGKILALDTPMGLKAMVQEDIVYEIEVSYSGDLDLNEIRGVRLIEKRFLDGKIYIKFSLREENLISNVLSYINEKGEKILFLRRKEPSLEEAFIKIVGRRTSKGIFSGSLLMSFFPFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYI6</accession>
    <name>B8DYI6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Cysteine synthase</fullName>
            <ecNumber evidence="4 10">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_0030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4 10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582454.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351982.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0030"/>
    <dbReference type="EnsemblBacteria" id="ACK41368">
        <property type="protein sequence ID" value="ACK41368"/>
        <property type="gene ID" value="Dtur_0030"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0030"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.31"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYI6"/>
    <dbReference type="OMA" id="FWDSGER"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080146">
        <property type="term" value="F:L-cysteine desulfhydrase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="6 8 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="11">
        <location>
            <begin position="10"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="8">
        <location>
            <begin position="179"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK41368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="311" mass="33710" checksum="2AED1126C82CC5CE" modified="2009-03-03" version="1">MRVANSVIELIGNTPLVKLNKITEGCFAEVLAKLESFNPGGSVKDRIALSMIEEAEKMGKLNKDKIIIEPTSGNTGIGLAMIGAIKGYKVILVMPESMSMERRALLRAFGAELILTPKEEGMKGAIKKVEEIISLDPDKYFVPMQFENSANPLIHKKTTAEEIWQDTEGKVDIVVCGVGTGGTITGIGEVLKQRKKEIKIVAVEPEKSAVLSGKTPSPHKIQGIGAGFIPKVLNTSIIDEIVTVSEEDAMNTAKKLMKEEGILCGISSGAACFAALKVAKREENKGKTVVVILPDTGERYISTELFDEYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYK4</accession>
    <name>B8DYK4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582472.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352000.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0048"/>
    <dbReference type="EnsemblBacteria" id="ACK41386">
        <property type="protein sequence ID" value="ACK41386"/>
        <property type="gene ID" value="Dtur_0048"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0048"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762328_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYK4"/>
    <dbReference type="OMA" id="IVAWKAS"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="183"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="363" mass="42259" checksum="85F13EF942D2E3CE" modified="2009-03-03" version="1">MTYFSLTSIGYLLIFFDIVLYLIGLNVSSTPVLLVSTFIMGLYMINFFEIILQPLNLRVKVQMPLLVKENEYEFINIYFENNSKIPKGQVFINLQGKTPLGGLRGKEKKEISIYFHFKKRGIFYLKTLNLRFTGTLGLLYLSKNYKVDGVTYIYPSFYPLSQDIYLTDGEGNKTSSSFLSVIGEEFHSLRDYQPQDPLKIVAWKASAKKGKLLSKNFEKLKKGSLMILIDNSVDKKDSIAEEEFDQLLRFVHSLLIPSFSLNIPLSIRDLRGEEEFNPKTSDELKKYLAEIQLIERRNISFKNYDYDIIFTLNYRFWDEKVKINKIIGVEYHKKEIVLNKGFIFSLGDDPQEFLSRFLVLNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYL1</accession>
    <name>B8DYL1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dipeptide epimerase</fullName>
            <ecNumber evidence="5">5.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4 5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the mandelate racemase/muconate lactonizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582479.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352007.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0055"/>
    <dbReference type="EnsemblBacteria" id="ACK41393">
        <property type="protein sequence ID" value="ACK41393"/>
        <property type="gene ID" value="Dtur_0055"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0055"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.56"/>
    <dbReference type="eggNOG" id="COG4948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030273_4_0_0"/>
    <dbReference type="InParanoid" id="B8DYL1"/>
    <dbReference type="OMA" id="MFGCYSD"/>
    <dbReference type="OrthoDB" id="951991at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016855">
        <property type="term" value="F:racemase and epimerase activity, acting on amino acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03319">
        <property type="entry name" value="L-Ala-DL-Glu_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034603">
        <property type="entry name" value="Dipeptide_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="6">
        <location>
            <begin position="140"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (R)-substrate epimerization" evidence="3">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for (S)-substrate epimerization" evidence="3">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR634603-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="343" mass="38828" checksum="BD082A04CD361C40" modified="2009-03-03" version="1">MAKIKRISFELKTYEYIKPFRIAPGTASHTHNLEVKIETEEGYIGLGEASPSFRVTGERIESLIPLESFVNELLKGKDTKNFRKIFEITDKFFAFPSLKTALQYAILDALSEELSLPVYQILGGAKEKIETDKTVSIGSVEERVREAEEIFKEGFKVIKVKIGLDLREDIETMEELVKRIKGVKYIVDANTAYNPKQAVIFTKELYKKGIDIELLEQPVPAHDLEGLKYVRFNSPFPIAGDESIKNKYEALEVIKMEAVDYINIKLMKCGISDALAIVEMANTANIKLMIGCMGESSLGINQSVHLSAGLGVFEFHDLDSALMIKEDKFRGKYKIRIPYYYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYL2</accession>
    <name>B8DYL2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-alpha-D-mannose</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the mannose-6-phosphate isomerase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582480.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352008.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0056"/>
    <dbReference type="EnsemblBacteria" id="ACK41394">
        <property type="protein sequence ID" value="ACK41394"/>
        <property type="gene ID" value="Dtur_0056"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0056"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.57"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYL2"/>
    <dbReference type="OMA" id="LIVCNEK"/>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006375">
        <property type="entry name" value="Man1P_GuaTrfase/Man6P_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01479">
        <property type="entry name" value="GMP_PMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="2"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="7">
        <location>
            <begin position="307"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="467" mass="53814" checksum="0B978515777AB59D" modified="2009-03-03" version="1">MKAIVLAGGKGTRLWPLSREKFSKQFIKLLPDKSLLEDTYERLIKFFKPEDILTITNKEYFYFVKSITDKFDKSMSHNTLLEPVGKNTAPAIALALKYILEKINGNPEEEVFIFPSDHLIEPQEKFIEYLNKSLSAVNSGFITTFGIKPTKPETGYGYIKAGENMGDFFKVEKFIEKPSLELAEKFLKEGNYFWNAGIFAFKISVMLEEFEKYQEEIYTLITKGSYREVLENFHKMPSISIDYAIAEKSDRVAVIPMELIWSDLGSWDSFYEVKEKDPNGNVLLGDVYAINTRNSLVFSNKRLVGTIGIEDAIIVETDDAILISKRGSGQEVKKLLEILENEGRNEIIYHTEVYRPWGMYKLLEKNGDYIIRKLIIKEGASLTCHLHKKRTEHWIVLKGIAEADIENRKYYVYEGESIFVPKGKPHQLKNAGENPLEIIEIQSGEILSEDDIEIFTKDEEELEEKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYL8</accession>
    <name>B8DYL8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582486.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352014.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0062"/>
    <dbReference type="EnsemblBacteria" id="ACK41400">
        <property type="protein sequence ID" value="ACK41400"/>
        <property type="gene ID" value="Dtur_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0062"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_2_3_0"/>
    <dbReference type="InParanoid" id="B8DYL8"/>
    <dbReference type="OMA" id="HSLPPFW"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="9"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="260" mass="28962" checksum="EFA7A190FD49A67D" modified="2009-03-03" version="1">MRTLMYDTYSVMWRELKHWMDQKVRILVSIFQPLIWLALMGNVMAKLTDNPFGRQAFGGASYLSFMTPGIIVMTSLFGGIFGGISVVWDRRWGYLNKMLAAPISRTAIPLGKMLATAIQGAFQSLIVVIIASLFGVEFATGIPGIIAIILLAACFNFTMAGLSIAIASRIKTMEVLTAVINFLTMPLMFTSSAMFPINVMPDWLATIARWNPITYVVNPLRTLVISGWETGDLIKGFLYVLFLAILMLFIARHEFKRSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYN2</accession>
    <name>B8DYN2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">4Fe-4S ferredoxin, iron-sulphur binding, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0076</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582500.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352028.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0076"/>
    <dbReference type="EnsemblBacteria" id="ACK41414">
        <property type="protein sequence ID" value="ACK41414"/>
        <property type="gene ID" value="Dtur_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0076"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_0"/>
    <dbReference type="InParanoid" id="B8DYN2"/>
    <dbReference type="OMA" id="VCYRCTR"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
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            <begin position="2"/>
            <end position="78"/>
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            <end position="117"/>
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            <begin position="180"/>
            <end position="209"/>
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            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
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            <name>[4Fe-4S] cluster</name>
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            <dbReference type="Proteomes" id="UP000007719"/>
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    <sequence length="559" mass="63496" checksum="9F97FE3C58DACCE1" modified="2009-03-03" version="1"> </sequence>
</entry>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <dbReference type="Proteomes" id="UP000007719"/>
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    <sequence length="324" mass="36794" checksum="5BDA7AFF2B3B248E" modified="2009-03-03" version="1">MEKILEVKNISKIYSVGSLFSRIRITAVDNVSFYIKPAEIFTLAGESGCGKTTLSKIILGFEEPNYGEILYEGKSTKNIDRIEFMKKVQGVFQNPFESFNPLITIEDIFFETIYNFKLATNKNEAIKIIEEKLNAVGLSFDDIHNRYPNELSGGQLQRASIARSLLTNPSILIADEPVSMVDASLRMSIINLFSKLKNQIGLSVLYITHDLATAYYVGDRIAIMFRGNIVEMGPVNKVLLYPKHPYTQLLLESIPKADPEKKWRENVTIADIEYTEYLKEGCKFAGRCSFVRDICKKEKPKEIMIDDVLVRCHLYSENKTTISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042512_0_0_0"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of cell shape"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Jag_KH"/>
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        <property type="entry name" value="Jag_N_dom_sf"/>
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        <property type="entry name" value="KhpB_N"/>
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        <property type="entry name" value="R3H_KhpB"/>
    </dbReference>
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        <property type="entry name" value="PTHR35800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14804">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01245">
        <property type="entry name" value="Jag_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="R3H" evidence="6">
        <location>
            <begin position="138"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="207" mass="23974" checksum="1F88ABE1530171BC" modified="2009-03-03" version="1">MKEIETEGKTLEEALLKAKAVLEVPLDKIEYKVLEYGKEGILGIGARPFRVLAWIRKNPEDALRNFLKELLWRLNLRARIRVIKEEGHIKISLEGENLGELIGPGGRTLSSLEFILRLFAAKNQITETITLDVDHYRERKEKYLSNLAKKIAEKVKKEKKEFHLKPMSSRERRIIHITLQNDPDVITYSIGEEPERRVVIAPRKNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYV1</accession>
    <name>B8DYV1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582568.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352097.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0152"/>
    <dbReference type="EnsemblBacteria" id="ACK41483">
        <property type="protein sequence ID" value="ACK41483"/>
        <property type="gene ID" value="Dtur_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0152"/>
    <dbReference type="HOGENOM" id="CLU_1452301_0_0_0"/>
    <dbReference type="OMA" id="ISGCART"/>
    <dbReference type="OrthoDB" id="2131118at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="186" mass="21578" checksum="8CBAC7EFAE5EA34A" modified="2009-03-03" version="1">MKKIVILLIVGLIFISGCARTVTQRPKGYLGISISFYRPLILSIDGSYYAFIIAFNENNVITEDPNTWQYYIEYDGFNQKFMWGRNDFSSYGTLLSGKFSEDGTNFSFKISLNLFSNATSLYMKIFYFVYDPFVYDPLQGFRDLYWQYPDSDSESIRIDLSNYPYSYNSVLTGNINIISGLSLWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYW8</accession>
    <name>B8DYW8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Potassium uptake protein, TrkH family</fullName>
            <ecNumber evidence="10">3.6.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.14" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352208.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0268"/>
    <dbReference type="EnsemblBacteria" id="ACK41594">
        <property type="protein sequence ID" value="ACK41594"/>
        <property type="gene ID" value="Dtur_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0268"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.281"/>
    <dbReference type="eggNOG" id="COG0168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026429_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYW8"/>
    <dbReference type="OMA" id="MFIGSAP"/>
    <dbReference type="OrthoDB" id="756220at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004772">
        <property type="entry name" value="TrkH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00933">
        <property type="entry name" value="2a38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="456" mass="50568" checksum="185C5B0265578D1C" modified="2009-03-03" version="1">MNLFMFEKELISKKRGFNPAVFFIISFAIVILTGAILLSLPISSAKGEFTNFLTALFTATSATCVTGLVVVDTGTYWSHFGHLVILLLIQIGGLSYAVISTGMMLLLNRRLQLRERLILQYSLNTTSLRGIVSFLKNVLITVFIFESIGALSLFFVFIKRYPLLRSIKFAIFHSVSAFCNAGLDLIGGFRSFTDYVSDPHLVFTITTLIIVGGIGFIVIHDIIQRFMGKRIHLSLHSKMALFTTLFLILIGTIVIFILEYNNPNTLKPLNFWGKFLGAYFQSVTPRTAGFNTLDIGKMNPSTLLFIIVLMFIGASPGGTGGGIKTVTFLVLWLSVSTIILERKNVHFKDRTIPWENVKRAYIVFLLSLTLVIISWFLLLITEPFPPLNILFEVVSAFGTVGLSTGITPYLSPFARLVIILTMFLGRVGTVTAGMAILIPVSKRSQVEYPSEEVSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYY6</accession>
    <name>B8DYY6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0289</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352226.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0289"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41612">
        <property type="protein sequence ID" value="ACK41612"/>
        <property type="gene ID" value="Dtur_0289"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0289"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.304"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_4_1_0"/>
    <dbReference type="InParanoid" id="B8DYY6"/>
    <dbReference type="OMA" id="LDLWDWT"/>
    <dbReference type="OrthoDB" id="949956at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="4">
        <location>
            <begin position="582"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="758" mass="86505" checksum="1E82E1EFC8AA3D14" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ13</accession>
    <name>B8DZ13_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582724.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352253.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41639">
        <property type="protein sequence ID" value="ACK41639"/>
        <property type="gene ID" value="Dtur_0318"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0318"/>
    <dbReference type="HOGENOM" id="CLU_131990_0_0_0"/>
    <dbReference type="OrthoDB" id="1692541at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="135" mass="16501" checksum="61F42A33FEE1C056" modified="2009-03-03" version="1">MKKERLSFLLGYILSQEEEVKKIYREIQNINPEMKEKTIYLAYNLHNLYNASFFHKEILKRMSIEIPGIRPKVLSKESFIILNELRGFRYIFRHAYNYEIIPEKVNMLKEKITKNWSIVEEDLNNFKNWLKENLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ26</accession>
    <name>B8DZ26_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582737.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352266.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0338"/>
    <dbReference type="EnsemblBacteria" id="ACK41652">
        <property type="protein sequence ID" value="ACK41652"/>
        <property type="gene ID" value="Dtur_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0338"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.358"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_6_1_0"/>
    <dbReference type="InParanoid" id="B8DZ26"/>
    <dbReference type="OMA" id="TFGVWSA"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="200" mass="22392" checksum="2BCC811D6A1FB716" modified="2009-03-03" version="1">MWVNLGVILLQFLSGSIMYSYIIARILKVDLSKIRDGNPGASNLWRAVGWKYGILALFLDYLKGALPLAIFVSLGIVKDNFVISLAALSGVLGHAFSPILRFKGGKAVAVSFGAWSVLTKWEAPMLLGTIFTIFTIIKPKGTTVQEDAFRVILGYLFLLPYIIYKSFHGDFHLLIFYDGNFAVILYKHYKDLWGYLRGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ31</accession>
    <name>B8DZ31_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582742.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352271.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0344"/>
    <dbReference type="EnsemblBacteria" id="ACK41657">
        <property type="protein sequence ID" value="ACK41657"/>
        <property type="gene ID" value="Dtur_0344"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0344"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.364"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_3_0"/>
    <dbReference type="InParanoid" id="B8DZ31"/>
    <dbReference type="OMA" id="WEEDCSA"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="79"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="166" mass="18812" checksum="B9C12A5A7229DE72" modified="2009-03-03" version="1">MNETIKTIKSRVSVRKFLEKEVPKEILEDLIDCGRLAPSGYNRQPWIFLVVTDKELKNRLAEITPWGRFLKEAGAGILIFCEKDAETALEDACAAGENIIIAAQSYGLGTCWINSYKKAYSEDVKRLVKCPDNMELMVMLAVGYPAEIPQRPPKKSLSEVLRWQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ40</accession>
    <name>B8DZ40_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582751.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352280.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0355"/>
    <dbReference type="EnsemblBacteria" id="ACK41666">
        <property type="protein sequence ID" value="ACK41666"/>
        <property type="gene ID" value="Dtur_0355"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0355"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.374"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_29_3_0"/>
    <dbReference type="InParanoid" id="B8DZ40"/>
    <dbReference type="OMA" id="DIYYSPQ"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="195" mass="22772" checksum="6DCC3BA8D17E032E" modified="2009-03-03" version="1">MRISKEPEIRKQELIETALKLFLSKGYEKTSVRDILREVKGSPGMFYYYFSSKEEIFEEAIKYYVENYIKELSQIFKDENLTLQEKYQKIVNAVVKAFEDMKSLSDIYYSPQYFPLRVKVSFKILDGLREPFAELIEKIKKDRNLDSKKTATFILYGVYGLLHKNAENLGEPSSIQSIMNFILELTGKILGTLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ44</accession>
    <name>B8DZ44_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative small multi-drug export</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582755.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352284.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0359"/>
    <dbReference type="EnsemblBacteria" id="ACK41670">
        <property type="protein sequence ID" value="ACK41670"/>
        <property type="gene ID" value="Dtur_0359"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0359"/>
    <dbReference type="eggNOG" id="COG2426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075669_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZ44"/>
    <dbReference type="OMA" id="PYVEKWG"/>
    <dbReference type="OrthoDB" id="2035652at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009577">
        <property type="entry name" value="Sm_multidrug_ex"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06695">
        <property type="entry name" value="Sm_multidrug_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="151" mass="16559" checksum="1C33A81FEC408CB2" modified="2009-03-03" version="1">MNISLIFKVFLLSMTPVGECRISIPYGIYNGLSPLESFIISFLGNTLMGIIIYNIINWIGKYILSKEPLKGYYDSFVRNKLKRLRIYSLGIVFSLAVFVAIPLPGTGAFTGAILARFLGLSLKEAIISITSGVLIASTIVTLLTLSSKVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ50</accession>
    <name>B8DZ50_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TM1410 hypothetical-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582761.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352290.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0372"/>
    <dbReference type="EnsemblBacteria" id="ACK41676">
        <property type="protein sequence ID" value="ACK41676"/>
        <property type="gene ID" value="Dtur_0372"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0372"/>
    <dbReference type="eggNOG" id="COG3868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525544_0_0_0"/>
    <dbReference type="OMA" id="PANNDDF"/>
    <dbReference type="OrthoDB" id="1722608at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_114" evidence="1">
        <location>
            <begin position="52"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="431"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="518" mass="59640" checksum="E7B2826A64CB972D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ60</accession>
    <name>B8DZ60_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582771.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352300.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0382"/>
    <dbReference type="EnsemblBacteria" id="ACK41686">
        <property type="protein sequence ID" value="ACK41686"/>
        <property type="gene ID" value="Dtur_0382"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0382"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="InParanoid" id="B8DZ60"/>
    <dbReference type="OMA" id="MMIMLLA"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="296" mass="34470" checksum="0694962DBD190CDD" modified="2009-03-03" version="1">MRVLGGIPKYKQAIYFFVFIVFSLVFALLAYYIPFGISFKLALSKYDAISEPQYIGLENFKKIFQDKVFWISLKNSFLYALYVVPTAVILSFLIAVGLNRNTKFFRFLRVFYFIPTVTSSVAINFVWLWFFNPEYGLLNTILGFLGVKKIYWLTDPKIALFSLAIVGIWGSLSYNIILFLAGLQNIPSTYYEAASLDGATKKDMLIHITLPLMTPIIFFVLIMQIISSVQMFESVFIMTRGGPGYSTYTLVYYIYRNGFNWFRMGYGTALSWILYFILLILTIIQFNLQRRWVYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ99</accession>
    <name>B8DZ99_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582917.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352446.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0542"/>
    <dbReference type="EnsemblBacteria" id="ACK41832">
        <property type="protein sequence ID" value="ACK41832"/>
        <property type="gene ID" value="Dtur_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0542"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_6_3_0"/>
    <dbReference type="InParanoid" id="B8DZ99"/>
    <dbReference type="OMA" id="HSIPLMF"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="2"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="71" mass="7258" checksum="16313C6723ADEEDB" modified="2009-03-03" version="1">MMALSFVKEGQEVKVIAIRGGKGAVQRLAEMGILPGVRIKVISNSGGPIVIALGNSRIALGKGLASKIICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZA5</accession>
    <name>B8DZA5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582923.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352452.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0548"/>
    <dbReference type="EnsemblBacteria" id="ACK41838">
        <property type="protein sequence ID" value="ACK41838"/>
        <property type="gene ID" value="Dtur_0548"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0548"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_12_3_0"/>
    <dbReference type="InParanoid" id="B8DZA5"/>
    <dbReference type="OMA" id="FQFKVEI"/>
    <dbReference type="OrthoDB" id="480174at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="426" mass="48188" checksum="605ADCBA9040033E" modified="2009-03-03" version="1">MKLRKVLSLILVLSFIIFLNLGGLNAAEKVKITLLSTKGEINAALEGVAKDFSKDYPNISLEIIPVGVGQSPFEKLSTMYASGNAPTLAMIDVNDVPKFKENFLDLSNEEWVKDAVKGALNDITFDKKVMAFPFTIEGYGLIYNQQAIEKVIGKFDPKTIDTRNKLEALFKKLEEKGLTPIVVSPLDWSLGAHFLTIGYVTQSSDPKKIDKFIEDLKAGKIDLSKNRKMNGLLDTLDMWKKYNYLKRSPLAGTYEQGAQLLATGKVAFWFMGNWAWPLIKEVNPNNVQYGFLPVFVSNIPNDYGNREIPVGVTKVIGIDMKQNSREQQEAARTFLNWLVYNKNGQNAWVNKLSVITPFKNVKLTPNDPLAKSIFEYMNQGRTLRFLVTLPPDHWPTVGASMQKYLANVISREQLFKEITDYWRKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZA7</accession>
    <name>B8DZA7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582925.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352454.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0550"/>
    <dbReference type="EnsemblBacteria" id="ACK41840">
        <property type="protein sequence ID" value="ACK41840"/>
        <property type="gene ID" value="Dtur_0550"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0550"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.586"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZA7"/>
    <dbReference type="OMA" id="FRQSTKM"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="275" mass="31516" checksum="B2E6B78DA5239B32" modified="2009-03-03" version="1">MNIVQKLTNFLKFAAILTIAIFYMSPFLMVIVNSFKQTSEIILNPFKLPESFSFANYLSAAIKMKYWNAFLNTLIITSFSITLIVIFSSMAAYIFVRKNWSINKIVFSMMIASMIIPFQSIMIPLVKIYGSLNLLNNKWTLIYMYLGFGTSFAVFMYHGFIKGIPYELEEAALVDGASEFQTFWKIVFPLLKPVTYTIVILDSLWIWNDFLLPSLVLISAEKRTLQLSTFYFYGTYNTDYGLAMAALMLAIIPIIIIYLLLQKYIIAGIMKGAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZB3</accession>
    <name>B8DZB3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0556</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582931.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352460.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0556"/>
    <dbReference type="EnsemblBacteria" id="ACK41846">
        <property type="protein sequence ID" value="ACK41846"/>
        <property type="gene ID" value="Dtur_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0556"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.592"/>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027268_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZB3"/>
    <dbReference type="OMA" id="CRGGCIN"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S" evidence="6">
        <location>
            <begin position="341"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="542" mass="61699" checksum="2C1CB228B7D292FA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZB4</accession>
    <name>B8DZB4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582932.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352461.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0557"/>
    <dbReference type="EnsemblBacteria" id="ACK41847">
        <property type="protein sequence ID" value="ACK41847"/>
        <property type="gene ID" value="Dtur_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0557"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.593"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703441_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZB4"/>
    <dbReference type="OMA" id="KIVCGGT"/>
    <dbReference type="OrthoDB" id="533349at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="379" mass="42495" checksum="0F9289C5A4536B9B" modified="2009-03-03" version="1">MLTCDVNFAFKSKEGEEVCGDSIKIKRSEDKVVVTVSDGLGSGIKASILSTLTASMTTTMLFNDMPMDEVMKSVLATLPKCKVRDISYANFCSVLFKAKENTCYIAEYEFPVVLLFRKNEFIDFEKKRLLVEDREIKESYFVPQDGDLLFVMTDGVSQAGLGTRLYPLGLGIENIKREIFNLTRYKVPPKEIVNYLIEKAKRLDKGIKGDDALLCVLYFRSFNRLNIMVGPPSDPNLDEYVAYKFLNMPGRKVICGGTTAQIVGRIMGSEVSLDLKTVSEDSPPVGYMEGVDLVTEGIITLTQVFRYLDGQIEKVGYGASLIIDLIEKSDEICFIVGKAINPAYQNPLFSYDMSLKFKIVKDIMDILKNKGKIVKIEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZC2</accession>
    <name>B8DZC2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">murJ</name>
        <name evidence="10" type="ordered locus">Dtur_0565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582940.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352469.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0565"/>
    <dbReference type="EnsemblBacteria" id="ACK41855">
        <property type="protein sequence ID" value="ACK41855"/>
        <property type="gene ID" value="Dtur_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0565"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_4_1_0"/>
    <dbReference type="InParanoid" id="B8DZC2"/>
    <dbReference type="OMA" id="IFFVAFK"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="534" mass="58925" checksum="E940226246CD4912" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZH5</accession>
    <name>B8DZH5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582993.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352522.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0620"/>
    <dbReference type="EnsemblBacteria" id="ACK41908">
        <property type="protein sequence ID" value="ACK41908"/>
        <property type="gene ID" value="Dtur_0620"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0620"/>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133784_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZH5"/>
    <dbReference type="OMA" id="CKRELWF"/>
    <dbReference type="OrthoDB" id="1594787at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="168" mass="19874" checksum="996D12D563E11B91" modified="2009-03-03" version="1">MVVPRLITGTLVESFLICKRQCWLMSHQITPDQDHPYLELGRFIDMESYNEEKKKVNLENVIIDLIKTENNTLLIGEIKKTSKAQESAKLQLLFYLYNLKYNYGIEAKGILLFPKEKKRIKVDLTEEEEKKIEKIIYEITEIIYKNLPPAPEKINYCIHCAYRELCWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZK6</accession>
    <name>B8DZK6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GIY-YIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583024.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352553.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0654"/>
    <dbReference type="EnsemblBacteria" id="ACK41939">
        <property type="protein sequence ID" value="ACK41939"/>
        <property type="gene ID" value="Dtur_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0654"/>
    <dbReference type="eggNOG" id="COG1833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115699_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZK6"/>
    <dbReference type="OMA" id="GCSDCRC"/>
    <dbReference type="OrthoDB" id="1750345at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd10441">
        <property type="entry name" value="GIY-YIG_COG1833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002837">
        <property type="entry name" value="DUF123"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37460">
        <property type="entry name" value="PTHR37460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01986">
        <property type="entry name" value="DUF123"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="19"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="136" mass="15902" checksum="4C708834DABD2FCE" modified="2009-03-03" version="1">MKGIYVLVLEVEEDIEVEVGSLGKLTFKKGIYLYVGSAQNNLEKRIKRHLSKDKKFHWHIDYLLANRKVKIVEVLYRELSKEWECKIAKSITGEIVSKFGASDCNCLSHLFKIDKSQIQFLRELRFKNLIIGETRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZN8</accession>
    <name>B8DZN8_DICTD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583056.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352585.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0686"/>
    <dbReference type="EnsemblBacteria" id="ACK41971">
        <property type="protein sequence ID" value="ACK41971"/>
        <property type="gene ID" value="Dtur_0686"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0686"/>
    <dbReference type="HOGENOM" id="CLU_1851979_0_0_0"/>
    <dbReference type="OMA" id="MVFDIIC"/>
    <dbReference type="OrthoDB" id="2165293at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="138" mass="15788" checksum="DA2DD87097740B15" modified="2009-03-03" version="1">MVFDIICTVTILGLALKGIKELFFNRLALIVSLIIAFSLSSVLMPIYGEYIRLPINLSSNISSFILTFILAYLLLTLPGFFLKVAVGGIILIIIYGVILNFIPLEYQKMIVQNSYIYSFIKPIVWYILILFRFLRIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZQ0</accession>
    <name>B8DZQ0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formiminotransferase-cyclodeaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583068.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352597.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0698"/>
    <dbReference type="EnsemblBacteria" id="ACK41983">
        <property type="protein sequence ID" value="ACK41983"/>
        <property type="gene ID" value="Dtur_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0698"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.736"/>
    <dbReference type="eggNOG" id="COG3404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088419_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZQ0"/>
    <dbReference type="OMA" id="VAMVARY"/>
    <dbReference type="OrthoDB" id="1965647at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007044">
        <property type="entry name" value="Cyclodeamin/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036178">
        <property type="entry name" value="Formintransfe-cycloase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04961">
        <property type="entry name" value="FTCD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101262">
        <property type="entry name" value="SSF101262"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FTCD_C" evidence="2">
        <location>
            <begin position="14"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="217" mass="23687" checksum="0634F2600B7D028E" modified="2009-03-03" version="1">MESYSKIKLINRAITEFIELLASQEPAPGGGAASSLVGAIGVALSSMVANLTVGKEKFKDKEELMNEIIEENKKIQKELLELIEKDAEAFSKVAKALKMPKGTEEEKNKRKEALETALKEAALVPLEIIRKSINALRLLEKSLGNSNPNAVSDIGVGAVCLKAALQGAWLNVKINLASIRDKDFVKNIQKEAESLLKDGILLSDKIYEEVESILQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZR6</accession>
    <name>B8DZR6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0714</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583084.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352613.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0714"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41999">
        <property type="protein sequence ID" value="ACK41999"/>
        <property type="gene ID" value="Dtur_0714"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0714"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.751"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358542_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZR6"/>
    <dbReference type="OMA" id="ATRIVIW"/>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008713">
        <property type="term" value="F:ADP-heptose-lipopolysaccharide heptosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="781" mass="91437" checksum="B6BDE725077DF344" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZR9</accession>
    <name>B8DZR9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoheptose isomerase</fullName>
            <ecNumber evidence="9">5.3.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sedoheptulose 7-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmhA</name>
        <name evidence="11" type="ordered locus">Dtur_0717</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.28" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583087.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352616.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0717"/>
    <dbReference type="EnsemblBacteria" id="ACK42002">
        <property type="protein sequence ID" value="ACK42002"/>
        <property type="gene ID" value="Dtur_0717"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0717"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066606_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZR9"/>
    <dbReference type="OMA" id="LEKSYMI"/>
    <dbReference type="OrthoDB" id="1571626at2"/>
    <dbReference type="UniPathway" id="UPA00041">
        <property type="reaction ID" value="UER00436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008968">
        <property type="term" value="F:D-sedoheptulose 7-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001061">
        <property type="term" value="P:D-glycero-D-manno-heptose 7-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00067">
        <property type="entry name" value="GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004515">
        <property type="entry name" value="Phosphoheptose_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="34"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="356" mass="40172" checksum="6EA621CB87735E3E" modified="2009-03-03" version="1">MEERIKARLRKHDFTLKLVEEYLISDIKKAAEIIIEKYKKGKKVLIFGNGGSAADAQHIVAELVGRFLKERKGIPAIALTTNSSNITSISNDYSFDEVFERQVEALLEEEDVVIGISTSGNSPNVVKALKKAKELKGVTIALSGRDGGEMIKYADISITVPFHMTPHVQEAHITIGHILCDLIEEKLFPSKNRAIFLDRDGTINEDKGYVYKTEDLVILPHVIEGLKLLQKRFLIIVVTNQSGVERGYYTIEDVDKFHRHLYYTLAKEKVYIDDFYYCPYLEGECRKPNPGMLIQAAKDWNIDLEKSYMIGDKITDVEAGKKAGCKTIIIGKENSLADFSAKNLLEAAQWILEKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZY8</accession>
    <name>B8DZY8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PSP1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583156.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352685.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0790"/>
    <dbReference type="EnsemblBacteria" id="ACK42071">
        <property type="protein sequence ID" value="ACK42071"/>
        <property type="gene ID" value="Dtur_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0790"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.829"/>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033149_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZY8"/>
    <dbReference type="OMA" id="YGGLGPC"/>
    <dbReference type="OrthoDB" id="1523756at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="1">
        <location>
            <begin position="68"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="300" mass="34663" checksum="71CE6B3558D18638" modified="2009-03-03" version="1">MMLEDKESIYVVGIRLRSLKVYYFSTTDPDLKVGDVVIVKTVQGMEAGRVVIPPFVPSENFEPPSPLKPILRRATEDDLKKIEEYREKEREVLRFAQEKAKTLNLPMKMLACEINFDYSKITIHFASEERVDFRELVKELAAQYKTRIELHQVGVRDEVRYLGGLGICGREVCCHLYLQDFESISVKMAKEQGLALNPLKISGICGRLMCCLSYEYKTYQDIKANLPPKGTVVETRQGKGVVVDHHVPLNKLVVEFDEERRELVSLDEIEKIYTKEEKERDKDKVLEKILKMLEEDDEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZZ2</accession>
    <name>B8DZZ2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha amylase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583160.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352689.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0794"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42075">
        <property type="protein sequence ID" value="ACK42075"/>
        <property type="gene ID" value="Dtur_0794"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0794"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_484623_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZZ2"/>
    <dbReference type="OMA" id="YDRFFHL"/>
    <dbReference type="OrthoDB" id="99080at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="138"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="562" mass="67022" checksum="FB83354F9FCC851E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E003</accession>
    <name>RF1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 1</fullName>
            <shortName evidence="1">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfA</name>
        <name type="ordered locus">Dtur_0805</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    <dbReference type="STRING" id="515635.Dtur_0805"/>
    <dbReference type="EnsemblBacteria" id="ACK42086">
        <property type="protein sequence ID" value="ACK42086"/>
        <property type="gene ID" value="Dtur_0805"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0805"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.843"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_0"/>
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    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:translation release factor activity, codon specific"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PCRF"/>
    </dbReference>
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        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
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        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000117237" description="Peptide chain release factor 1">
        <location>
            <begin position="1"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <sequence length="367" mass="42486" checksum="D245F84DD286839F" modified="2009-03-03" version="1">MLQKLVIDKLEEIEKRFEEIEGLLAKEDVISDFNKYQSLLKERAKIEEIVDKFREYKRLLKEKEDLEEMVKEEQDEDLRSLAETELEDIQEKLEKVEFELKALLLPKDPNDEKNIIMEIRAGTGGEEAALFAADLFRMYLGYAQKKGWKVEIVSSNPTGLGGFKEIIFIVEGKGAYSRLKFESGVHRVQRVPITESSGRIHTSTATVAVLPEMEEIEVEIDPKDLRIETFRSGGAGGQHVNKTESGVRITHIPSGIVVQCQDERSQHQNREKAMKVLRARLYEYYQREKENEIASQRRQQVGTGERSEKIRTYNFPQRRVTDHRINYSSFQLEEVLSGELDEFIDRLILAEKEEQIKKLFEEVGATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E020</accession>
    <name>B8E020_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-(Acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0822</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583187.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352717.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0822"/>
    <dbReference type="EnsemblBacteria" id="ACK42103">
        <property type="protein sequence ID" value="ACK42103"/>
        <property type="gene ID" value="Dtur_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0822"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.861"/>
    <dbReference type="eggNOG" id="COG1043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061249_0_0_0"/>
    <dbReference type="InParanoid" id="B8E020"/>
    <dbReference type="OMA" id="ECVTINR"/>
    <dbReference type="OrthoDB" id="971098at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="7">
        <location>
            <begin position="170"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="257" mass="28634" checksum="B7C2887C5A0F8441" modified="2009-03-03" version="1">MNSIISEKAEIGEKVEIGPFCVIEDGVKIGNNTKIESFVHIKKGTIIGENCHIHSGCILGDIPQDLGFKNEESFLIIGNNVVIRENCVFHRATGEGNATVIGDGCYLMAYVHVAHNVRIGNNVIIANGTQIAGYVEVEDKAFISGLVGIHQFVRIGRYAMIGVSTKLVRDVPPYSLCDGNPARVYGINVVGLKRNNFSPEKIRIIRSLFHLIYDKSIPFEERLKLLRDKEEEEAKILYEFITNSKRGITDASWRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E033</accession>
    <name>B8E033_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583200.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352730.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0835"/>
    <dbReference type="EnsemblBacteria" id="ACK42116">
        <property type="protein sequence ID" value="ACK42116"/>
        <property type="gene ID" value="Dtur_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0835"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="InParanoid" id="B8E033"/>
    <dbReference type="OMA" id="ADRANDW"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="235" mass="26451" checksum="271FEB95535734BD" modified="2009-03-03" version="1">MEDVFVLDNVVKIYKMDSVETIALNGVSLRVEKGEFIAIMGPSGSGKSTMMHLMGCLDRPTSGKIYFEGKDVSTLSDDELAEIRNKKIGFVFQSFYLLPRYDALQNVELPLIYRGVPPKERREKAKLILEKIGLGDRLHHRPTQLSGGQQQRVAIARALIVDPVVLLADEPTGNLDSKSSHEIMELISRLHKEENLTIVLVTHEADIASYAEKIIRMQDGKIVDIEDRKREISHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E037</accession>
    <name>B8E037_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583204.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352734.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0839"/>
    <dbReference type="EnsemblBacteria" id="ACK42120">
        <property type="protein sequence ID" value="ACK42120"/>
        <property type="gene ID" value="Dtur_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0839"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="InParanoid" id="B8E037"/>
    <dbReference type="OMA" id="MGSNMIT"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="311"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="405" mass="43965" checksum="9408A9C6609ADA52" modified="2009-03-03" version="1">MFLEIIKMALHSFSTNKLRTFLTTLGIIIGVAAVVTLMSLGEGTKATIEKQFTSLGSNLLTVFPRFGRGIGLVRGAPRSSITNDDYEALSKELDPNKVVAIVPYSSRNVQVKYKSENTNTQVIGTSPDYLKVREVKVANGSFFSEEEYKASKKVAVLGASVAETLFGNDDPIGQSIKIAGVTFKVVGVLEPQGQLGGFANLDDMIFIPLTTFQRKIQGGNSLNNIYISAISPDVMNDLQSQIEDILRKRHKITDPNNDDFMVQNQLTILSSLNQSMQTLTLFLAGIAAISLLVGGIGIMNIMLVNVTERIKEIGIRKAVGAKARYILYQFLTESVIVSVAGGIFGILVGIVLSQVIKSLSGLSAVVTLYPVVLSFTVSALVGIFFGYYPAYRASKLNPIEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E038</accession>
    <name>B8E038_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583205.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352735.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0840"/>
    <dbReference type="EnsemblBacteria" id="ACK42121">
        <property type="protein sequence ID" value="ACK42121"/>
        <property type="gene ID" value="Dtur_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0840"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.879"/>
    <dbReference type="eggNOG" id="ENOG5033MKW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1419461_0_0_0"/>
    <dbReference type="OMA" id="YHLSIYK"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002871010" evidence="1">
        <location>
            <begin position="24"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="192" mass="22904" checksum="43729869CFB694F1" modified="2009-03-03" version="1">MRRIKAVLGLVFIILFFVSVVNAQTTQTQTPRRGFMSQEVQYLTRLIRDLRELDKDKKVAITKDQARKLISILQELGKMSELPKKEADKFISRIEGTLTDAQLTYLDKLQIERQKRIEEMRQKMSQQQSSSQQPQFNPQLRNQQNFQMSERERQEFQKFMDAWSKGKPLNPFYHLSIYKKQLNDLIDYLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E040</accession>
    <name>B8E040_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MlpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583207.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352737.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0842"/>
    <dbReference type="EnsemblBacteria" id="ACK42123">
        <property type="protein sequence ID" value="ACK42123"/>
        <property type="gene ID" value="Dtur_0842"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0842"/>
    <dbReference type="eggNOG" id="COG3678">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347113_0_0_0"/>
    <dbReference type="OMA" id="ILTRIMW"/>
    <dbReference type="OrthoDB" id="2129218at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="102"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="213" mass="25679" checksum="B98BAA2431E34C05" modified="2009-03-03" version="1">MKKVVKILGVVLVLLTMMLAFSYASSFRSTPVVQRERIRVIERDRLMLQNSLQFSQEFRNLIRERDRIQAQIQLLLRSGKVNSDELQKYLTQLEDIENKLFAEFKKDLINNLSNALKLKEEQRQKVAEILNKYMDDIRNLRIELRNKNLEMRALGINEQSKQREIKDKIQKLRNEIREKRTAMLNELKQVLDQNQFRILTRIMWRYNIKIKVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E048</accession>
    <name>B8E048_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Riboflavin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the prokaryotic riboflavin transporter (P-RFT) (TC 2.A.87) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583215.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352745.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0850"/>
    <dbReference type="EnsemblBacteria" id="ACK42131">
        <property type="protein sequence ID" value="ACK42131"/>
        <property type="gene ID" value="Dtur_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0850"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.889"/>
    <dbReference type="eggNOG" id="COG3601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086673_0_1_0"/>
    <dbReference type="InParanoid" id="B8E048"/>
    <dbReference type="OMA" id="MFLEFPI"/>
    <dbReference type="OrthoDB" id="1497256at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032217">
        <property type="term" value="F:riboflavin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032218">
        <property type="term" value="P:riboflavin transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025720">
        <property type="entry name" value="RibU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38438">
        <property type="entry name" value="PTHR38438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037778">
        <property type="entry name" value="UCP037778_transp_RibU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="177" mass="19069" checksum="FFFBAAA91D1706E7" modified="2009-03-03" version="1">MGTKKLVFVSILTALSIILSITIYFPILPQAPYLLYDPGDIPLILISTQVGISHGILATLIVAILMAVLTGQGGPIGALMHFLASGTLIVVSGYVYTKTKNLILGLTFGTISMAIVMAVANIIFTPIYLGVPRNTIYPLIFPVIIPFNLIKAGINSIITYILLSISLIRTYFEKMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E070</accession>
    <name>B8E070_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD superfamily (Subfamily IIIA) phosphatase, TIGR01668</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583237.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352767.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0872"/>
    <dbReference type="EnsemblBacteria" id="ACK42153">
        <property type="protein sequence ID" value="ACK42153"/>
        <property type="gene ID" value="Dtur_0872"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0872"/>
    <dbReference type="eggNOG" id="COG2179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056221_4_0_0"/>
    <dbReference type="InParanoid" id="B8E070"/>
    <dbReference type="OMA" id="VLNPYHI"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF25">
        <property type="entry name" value="PTHR19288:SF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="173" mass="20344" checksum="ABC8E5A99A614541" modified="2009-03-03" version="1">MLDILKPKRFVDSIFDINFEDLYKRGYRGIIFDLDNTIVPWDGNELDPKTKDLIDHIKNIGFKVVILSNNWSHRRVKYFSKIMKLPALGSAFKPRVRSFKKAMKLMDTEPETTLVIGDRILTDIFGGNKIGMYTILVAPINKNEMWIKKWTVRKLENWLLDLWIRRGEITKGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E088</accession>
    <name>RSMH_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">Dtur_1255</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583615.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353147.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E088"/>
    <dbReference type="SMR" id="B8E088"/>
    <dbReference type="STRING" id="515635.Dtur_1255"/>
    <dbReference type="PRIDE" id="B8E088"/>
    <dbReference type="EnsemblBacteria" id="ACK42533">
        <property type="protein sequence ID" value="ACK42533"/>
        <property type="gene ID" value="Dtur_1255"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1255"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1295"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_3_0_0"/>
    <dbReference type="InParanoid" id="B8E088"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000386860" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="36"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <sequence length="295" mass="34436" checksum="8116273779B1A489" modified="2009-03-03" version="1">MEEIEIIHKPVMLKEVIHYLKLSPGKIVVDATLGLGGHSSEILRELKGEGLLIGIDRDEEVLNLARERLRKIANNFVLFNTTYDKVQEILKELKLSFIDAILFDLGFSSFHIEKSERGFSFMRPEEPLDMRYSKDTTLTAADILNSFNELELSNLFWEYGEEPLSRKLAKKIVERRKEKKFVYVKDLLEVVEEVIPKRKRHEATKVFQALRIVVNDEVNILKRALDQIPFILAPRGRIVVLTYHSIEDRVVKNFFKSHSDKIFPVNKKVIRPSVNEIRENRRARSAKLRVGERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E096</accession>
    <name>B8E096_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gyrA</name>
        <name evidence="11" type="ordered locus">Dtur_1263</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583623.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353155.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1263"/>
    <dbReference type="EnsemblBacteria" id="ACK42541">
        <property type="protein sequence ID" value="ACK42541"/>
        <property type="gene ID" value="Dtur_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1263"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1303"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_0"/>
    <dbReference type="InParanoid" id="B8E096"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009330">
        <property type="term" value="C:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="10"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="428"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="525"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="808" mass="91393" checksum="3D4CD0C86A68FDC3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0A6</accession>
    <name>B8E0A6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="9">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gltX</name>
        <name evidence="13" type="ordered locus">Dtur_1273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583633.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353165.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1273"/>
    <dbReference type="EnsemblBacteria" id="ACK42551">
        <property type="protein sequence ID" value="ACK42551"/>
        <property type="gene ID" value="Dtur_1273"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1273"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1313"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_0"/>
    <dbReference type="InParanoid" id="B8E0A6"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="4"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_2" evidence="12">
        <location>
            <begin position="332"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="242"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="477" mass="56106" checksum="085EF9416A1B4033" modified="2009-03-03" version="1">MDSVRVRIAPSPTGYLHVGTAHTALFNWLFARHNKGTFILRIEDTDLARSTKEYEENIIEGLKWLGLYWDEGPYYQTQRLDLYRKYADELLRKGLAYYCYCTPEELEERRKEALAQKKPPKYDRKCLYLSDEERARYEREGRKPAIRLLVPEGKTVFNDIIRGEIEFNNEDIGDFVIMKSDGIPTYNFAVVIDDYTMGITHVIRGEDHISNTPKQLFIYQAFGWSPPEFAHLPLLLGPDRSKLSKRHGVTSVTEYKNMGYLPQALVNYLALLGWTPEENKEIYTVEELIELFDLRRVTKNPGIFDVTKLEWINTQHIRRLSLEELADLTYPFLKEAEWFKEENFKREYYLKVLTLLQERLKTLAQIREYADYFFVDDLDYDVEIAKKVCKHPDTPLYLEKIKEVWSQIQEFTAENLENSLRNLAEENQIPTKNLVHPIRVALTNKTVGPGLYEIAEVLGKDKTLKRLEKFIEFLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0B8</accession>
    <name>B8E0B8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583645.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353177.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1285"/>
    <dbReference type="EnsemblBacteria" id="ACK42563">
        <property type="protein sequence ID" value="ACK42563"/>
        <property type="gene ID" value="Dtur_1285"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1285"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1326"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555216_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0B8"/>
    <dbReference type="OMA" id="IWILKLD"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02608">
        <property type="entry name" value="delta_60_rpt"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870568" evidence="1">
        <location>
            <begin position="25"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="491" mass="52785" checksum="0475A8B61CD14E48" modified="2009-03-03" version="1">MRKFFLLLSVFLIFSLLISGCSPKKDTTPPQVTITNPQDGQTVSGTVIIRATASDNVGVSKVEFYIDGTKVGEDTSSPYEYSWNTTQYADGNHTIQVRAIDNAGNVGSASITVNVQNAQQQVWQKTYGGSNLDWASSIQQTTDGGYIVAGWTESFGAGNMDFYIIKLDSNGNKVWEKTYGGSENDVAYSIQQTSDGGYIVAGGTYSFGAGSADFYIIKLDSNGNKVWGKTYGGSSWDWAYSIQQTSDGGYIVAGETSSFGAGGSDFYIIKLDSNGNKVWGKTYGGSNDEWARSIQQTTDGGYIVAGTTYSFGAGYDDFYIIKLDSNGDKVWEKTYGGSSYDEAYSIQQTSDGGYIVAGYTNSFGAGRSDFYIIKLDSNGDKVWEKTYGGSSYDEAYSIQQTSDGGYIVAGYTESFGAGNGDFYIIKLDSNGDKVWEKTYGGSSYDRAYSIQQTSDGGYIVAGGTSSFGAGSADFYIIKTDSEGNTGPYPTQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0D9</accession>
    <name>SYFA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheS</name>
        <name type="ordered locus">Dtur_1310</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583666.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353198.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0D9"/>
    <dbReference type="SMR" id="B8E0D9"/>
    <dbReference type="STRING" id="515635.Dtur_1310"/>
    <dbReference type="EnsemblBacteria" id="ACK42584">
        <property type="protein sequence ID" value="ACK42584"/>
        <property type="gene ID" value="Dtur_1310"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1310"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1355"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0D9"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000119392" description="Phenylalanine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with beta subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <sequence length="339" mass="39425" checksum="67DF4848D6968F63" modified="2009-03-03" version="1">MNEEYIEKFKEAKEKILRAQNLTELEEVKRVYLGKQGFLTQILRSIGKMPQEERAKWGRLANEWKEELESLYENKEKELKYLTLQKKLEEEKIDITLPGRRKILGRIHPINQVIEEIVMVFKEMGFQVVYGPELETDYYNFTALNIPMDHPVRESHDSFYIDKEHLLRTQTSPVQIRVMENKKPPLRVVAPGKCYRRDIPDATHSPMFHQIEGLVVDTDVTFAELKGVLTIFAHRLFGKDRKVYFIPSYFPFTEPSAEMYVECGVCKGAGCKACGYSGVLEILGCGMVHPQVFRIVGIDPEKYTGFAFGMGPDRIAMQIYGIDDIRLFYENDVRFLKQF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0E2</accession>
    <name>RL35_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmI</name>
        <name type="ordered locus">Dtur_1313</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583669.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353201.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0E2"/>
    <dbReference type="SMR" id="B8E0E2"/>
    <dbReference type="STRING" id="515635.Dtur_1313"/>
    <dbReference type="EnsemblBacteria" id="ACK42587">
        <property type="protein sequence ID" value="ACK42587"/>
        <property type="gene ID" value="Dtur_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1313"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1358"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_4_3_0"/>
    <dbReference type="InParanoid" id="B8E0E2"/>
    <dbReference type="OMA" id="PKIKTHR"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000127342" description="50S ribosomal protein L35">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="66" mass="7691" checksum="FAFAA50688AF7AE4" modified="2009-03-03" version="1">MSKLKTRSSAAKRFKVTATGKILHKKAGKRHNLSKKSESRKRRLDIPGEIKSVDRWKVERMLPYNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0G7</accession>
    <name>RNPH_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease PH</fullName>
            <shortName evidence="1">RNase PH</shortName>
            <ecNumber evidence="1">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rph</name>
        <name type="ordered locus">Dtur_1338</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583693.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353226.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0G7"/>
    <dbReference type="SMR" id="B8E0G7"/>
    <dbReference type="STRING" id="515635.Dtur_1338"/>
    <dbReference type="EnsemblBacteria" id="ACK42612">
        <property type="protein sequence ID" value="ACK42612"/>
        <property type="gene ID" value="Dtur_1338"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1338"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1383"/>
    <dbReference type="eggNOG" id="COG0689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050858_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0G7"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000129338" description="Ribonuclease PH">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <sequence length="240" mass="26696" checksum="25F16E0C0C25ED76" modified="2009-03-03" version="1">MVRIDKRSNTDLRPVKITRKYLKYPLGSVLIEMGETKVICTVSMEEKVPPFLKGTNQGWLTAEYGMLPGSTPERKVRDVVKGAINGRSQEIQRLIGRSLRAVVDFSKLGERTIWIDADVIQADGGTRTAAITGAFVALYDALEKLKREGIIKEIPIREFVAAVSVGIVDGEILLDLSANEDMRAEVDMNVVMTESGKFVEIQGTAEKTPFTHEQLQHMLNLAKQGIMRLIEIQKKTLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0H3</accession>
    <name>B8E0H3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylaspartate ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Dtur_1344</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = mesaconate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12829"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:36986"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="4.3.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylaspartate ammonia-lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.2" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583699.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353232.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1344"/>
    <dbReference type="EnsemblBacteria" id="ACK42618">
        <property type="protein sequence ID" value="ACK42618"/>
        <property type="gene ID" value="Dtur_1344"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1344"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1389"/>
    <dbReference type="eggNOG" id="COG3799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055277_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0H3"/>
    <dbReference type="OMA" id="RIEGPMD"/>
    <dbReference type="OrthoDB" id="254720at2"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00618"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050096">
        <property type="term" value="F:methylaspartate ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03314">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006395">
        <property type="entry name" value="Me_Asp_am_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022662">
        <property type="entry name" value="MeAsp_NH4-lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022665">
        <property type="entry name" value="MeAsp_NH4-lyase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07476">
        <property type="entry name" value="MAAL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05034">
        <property type="entry name" value="MAAL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017107">
        <property type="entry name" value="MAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00007">
        <property type="entry name" value="methylaspartate_ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01502">
        <property type="entry name" value="B_methylAsp_ase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAAL_N" evidence="14">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MAAL_C" evidence="15">
        <location>
            <begin position="163"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>(2S,3S)-3-methyl-L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR017107-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACK42618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="417" mass="47465" checksum="1624A806E2783123" modified="2009-03-03" version="1">MIKDALYSIGLSGFYFDDQRAIKAGAKEDGFAYRGIPLTSGYESVRQKGESISVILILDDDQIAFGDCAAIQYSGAGGREPLFKAKELVKDLENVVFPFLFQEKWESFRFICQKLETLSINGRKLHTALRYGVSQAILDAFSKYYKKTMTEIIRDEYLLNFDIKKIPIFAQSGDERYINVDKMILKRVDVLPHALINNVETKLGWRGEKLIEYLGWLKERVKILGDENYHPIFHIDVYGTIGIAFQYNIDEIVEYMEKLEKICYPYKLRIEGPVDMESKELQIDFLSKIKRKLKERGINVDIVADEWCNSLDDIKDFIKAEAVDMIQIKTPVLGSIHNSIEAVLYCKENNIGAYLGGSCNETDRSAQVSVHIALATQADQILAKPGMGVDEGLMIVYNEMMRTLKILKKKGLNVIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0H4</accession>
    <name>B8E0H4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamate mutase epsilon subunit</fullName>
            <ecNumber evidence="4">5.4.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glutamate mutase E chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glutamate mutase large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Methylaspartate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">glmE</name>
        <name evidence="5" type="ordered locus">Dtur_1345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2S,3S)-3-methyl-L-aspartate = L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12857"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="5.4.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methylaspartate mutase GlmE subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583700.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353233.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1345"/>
    <dbReference type="EnsemblBacteria" id="ACK42619">
        <property type="protein sequence ID" value="ACK42619"/>
        <property type="gene ID" value="Dtur_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1345"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1390"/>
    <dbReference type="eggNOG" id="COG4865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029922_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0H4"/>
    <dbReference type="OMA" id="VIVKTPH"/>
    <dbReference type="OrthoDB" id="809497at2"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00245">
        <property type="entry name" value="Glm_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.970.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01923">
        <property type="entry name" value="Me_Asp_mutase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006396">
        <property type="entry name" value="Glu_mut_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014714">
        <property type="entry name" value="Glu_mut_E_C_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06368">
        <property type="entry name" value="Met_asp_mut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001495">
        <property type="entry name" value="Met_asp_mut_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01503">
        <property type="entry name" value="MthylAspMut_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="3 4" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="L-glutamate binding" evidence="4">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="483" mass="54333" checksum="C0A9330FE6FB957D" modified="2009-03-03" version="1">MVLKNKKWDHKYFLKMREEVLNSWETGREVNFEEAVSYLSSLPREKYADYVLRKADESKKTLLQPRAGVPILKEHILLLQYLQKEGGADILPTTIDSYTRQNRYREAQLGIEESLREGRSLLNGFPAVNYGVRACREIIESVDVPVEVRHGTPDARLLAEITLAAGFTSFEGGGITYNIPYAKDVSLENSILYWQYVDYLVGLYAENGVIINRESFGPLTGTLVPPSISISIGIIEALLAAEQGVKSFSVGYGQCGNIIQDTASINVLYRLTKEYLASFGYYDVHVTTVLHHFMGGFPEDEARAYAVISLGTVPAVLSKATKVIVKTPQEAIGIPSKEANAAALRNTRQVLQMLDSQDFIDKNKLQEEEYIIEREVRSILNSVYSIGEGDLVLGTVRAFSSGLLDVPFAPSRFTLGRVMPIRDNEGAVRFFDFGNLPFDEEIKDFHRKKIEERAKYEKREISFQMVLDDIYAISKGRLVGRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0N4</accession>
    <name>B8E0N4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">carB</name>
        <name evidence="8" type="ordered locus">Dtur_1782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584128.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353668.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1782"/>
    <dbReference type="EnsemblBacteria" id="ACK43054">
        <property type="protein sequence ID" value="ACK43054"/>
        <property type="gene ID" value="Dtur_1782"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1782"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1834"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0N4"/>
    <dbReference type="OMA" id="IEPAGIH"/>
    <dbReference type="OrthoDB" id="48855at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="130"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="670"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="5">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="5">
        <location>
            <begin position="928"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="816"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="830"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="832"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK43054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1054" mass="118856" checksum="C33924F2CB0742D4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Q1</accession>
    <name>B8E0Q1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Beta-glucosidase</fullName>
            <ecNumber evidence="3 11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_1799</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3 11"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584145.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353685.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1799"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK43071">
        <property type="protein sequence ID" value="ACK43071"/>
        <property type="gene ID" value="Dtur_1799"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1799"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1851"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_0"/>
    <dbReference type="InParanoid" id="B8E0Q1"/>
    <dbReference type="OMA" id="VEACDRK"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017736">
        <property type="entry name" value="Glyco_hydro_1_beta-glucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="Glyco_hydro_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03356">
        <property type="entry name" value="BGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6 11 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="405"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR617736-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK43071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="446" mass="52140" checksum="5CBF27B79D7F6272" modified="2009-03-03" version="1">MVKLVFPKDFLWGTATASYQIEGAWNEDGKGESTWDRFSHTPGAIYQNQNGDVACDHYHRYEEDVKLMAEIGLKAYRFSISWPRIFPEGRGKINPKGVSFYERLINKLLEKNIKPAITLYHWDLPQALEDKGGWLNRDTAKYFSEYASFIFYKFGDMVPIWITLNEPFVNAFLGYAWGWHAPGKKDLKGAFVAGHNLLLAHGLAVQAYKEGGYNGNIGITINVAAVYPYTNSEEDLRAVQVQDAFENRWFIEPIFRKKYPEVIWKILEKNYLSFDFPISDFDIISSPIDFLGINYYTRNIVAHDESNKFLGLKRIEGPNERTEMGWEIYPDGLYDILIQLYRDYKIPIYITENGAAYNDKLENGKVEDNKRIEYLREHIKRAYFAIRDGVDLRGYFIWSLMDNFEWAHGYSKRFGIIYVDYDTQKRILKDSAYFYKKVIEENGIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Q9</accession>
    <name>B8E0Q9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584153.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353693.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1808"/>
    <dbReference type="EnsemblBacteria" id="ACK43079">
        <property type="protein sequence ID" value="ACK43079"/>
        <property type="gene ID" value="Dtur_1808"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1808"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1860"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_15_1_0"/>
    <dbReference type="InParanoid" id="B8E0Q9"/>
    <dbReference type="OMA" id="KPWCAGI"/>
    <dbReference type="OrthoDB" id="1746871at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK43079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="414" mass="45795" checksum="B584822F875E8FD3" modified="2009-03-03" version="1">MFRKIIMILLISILLLSVSSMAQLKGKLEIFSWWTAGGEAEGLQALIDIFHKKYPNVEIINATVAGGAGANAKAVLKTRMLGGDPPDTFQVHAGHELIDTWVKTGFMEPITFLYKQEGWAKVMPKGILDIVSYKGDYWSVPVNIHRANVLWYNKKIFEENNLTPPKTFEDFFKVADALKSKGITPFALGTKDGWEAAHVFETVLIGKLGAEGYKGLWDGKTKWSDPRVTDALETFKKMLTYVNSDHSARTWDEACALIVDGSAAMTIMGDWAVGYFYAKGFNDFGWVLAPGNAGIFDALSDSFGLPKGAKNRDNVIAFLKVLGSKEGQEAFNLKKGSIPARTDVDKSKFPPYQRSCMEDWLKHKIVPSVMHGAAASEGWVTEFKDVISLFVVRPDVKTTQKALVNVAIKNGVKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0R9</accession>
    <name>SYS_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA synthetase</fullName>
            <shortName evidence="1">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serS</name>
        <name type="ordered locus">Dtur_1382</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583734.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353270.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0R9"/>
    <dbReference type="SMR" id="B8E0R9"/>
    <dbReference type="STRING" id="515635.Dtur_1382"/>
    <dbReference type="EnsemblBacteria" id="ACK42656">
        <property type="protein sequence ID" value="ACK42656"/>
        <property type="gene ID" value="Dtur_1382"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1382"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1428"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0R9"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000199475" description="Serine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <sequence length="425" mass="49242" checksum="0B3781A601CDAC70" modified="2009-03-03" version="1">MIDIKILRENPEIMKENIILRNLDPQKYDVDYIIELDAKRRSLQKELDNLRAQRNKISQEIGKHQGEEREKLIKEAKILKEKIEELAKEYDNVEKELFSRLWQLPNFLSPKAPRGKDEKDNVEIKKWGEIKTFNFTPKDHLDLALLNDLVDFERGSKVTGSNFYYLKNEAVLLEFALFRLVIDTLLPEGFKLFITPDLARMEIIDGIGFQPRGPEAQIYRVEDTDLGLIATAEITLGGYHKDEILDELDLPLKYLGFSHCFRTEAGAYGRYNRGLYRVHQFSKAEIFIICRPEDSEEMHEYILGLEEKIFQKLEIPYRVLDICSGDLGAPAARKFDIEAWMPGRGEFGEVTSCSNCTDYQARRLNIRFRRVTGEVEYVHMLNGTAIAISRALIAIFENYQQEDGSILIPKALQPYIGISEIRPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0V9</accession>
    <name>B8E0V9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ordered locus">Dtur_1422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583774.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353310.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1422"/>
    <dbReference type="EnsemblBacteria" id="ACK42696">
        <property type="protein sequence ID" value="ACK42696"/>
        <property type="gene ID" value="Dtur_1422"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1422"/>
    <dbReference type="eggNOG" id="COG1828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164833_3_0_0"/>
    <dbReference type="InParanoid" id="B8E0V9"/>
    <dbReference type="OMA" id="IENYRFE"/>
    <dbReference type="OrthoDB" id="2012814at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="83" mass="9585" checksum="D1809FD946927658" modified="2009-03-03" version="1">MKKWTVILEIFLKEGIFDPQGKTVKDALHNLGFKEVEEVRIGKVLKIDILGENKEEIISKVKKMSEIFLANPVTEDFVIRVEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0X9</accession>
    <name>RPOZ_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="1">RNAP omega subunit</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoZ</name>
        <name type="ordered locus">Dtur_1442</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583794.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353330.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0X9"/>
    <dbReference type="SMR" id="B8E0X9"/>
    <dbReference type="STRING" id="515635.Dtur_1442"/>
    <dbReference type="EnsemblBacteria" id="ACK42716">
        <property type="protein sequence ID" value="ACK42716"/>
        <property type="gene ID" value="Dtur_1442"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1442"/>
    <dbReference type="eggNOG" id="COG1758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2805555_0_0_0"/>
    <dbReference type="OMA" id="KIAYGEG"/>
    <dbReference type="OrthoDB" id="1864134at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000121214" description="DNA-directed RNA polymerase subunit omega">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <sequence length="67" mass="7708" checksum="16098DFDCAB3CAEE" modified="2009-03-03" version="1">MKEVNIDTLISKIPNKYVLTVVISKRARQLFEELKFLKTIARDPLILAMEEIAQEKIAYGEGDDLED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Y1</accession>
    <name>Y1444_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative regulatory protein Dtur_1444</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_1444</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583796.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353332.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0Y1"/>
    <dbReference type="SMR" id="B8E0Y1"/>
    <dbReference type="STRING" id="515635.Dtur_1444"/>
    <dbReference type="EnsemblBacteria" id="ACK42718">
        <property type="protein sequence ID" value="ACK42718"/>
        <property type="gene ID" value="Dtur_1444"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1444"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1491"/>
    <dbReference type="eggNOG" id="COG2052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165326_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0Y1"/>
    <dbReference type="OMA" id="RDRNMLI"/>
    <dbReference type="OrthoDB" id="1786332at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01503">
        <property type="entry name" value="RemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007169">
        <property type="entry name" value="RemA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38449">
        <property type="entry name" value="PTHR38449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04025">
        <property type="entry name" value="DUF370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000373787" description="Putative regulatory protein Dtur_1444">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01503"/>
        </source>
    </evidence>
    <sequence length="85" mass="9192" checksum="E0E95F385883C488" modified="2009-03-03" version="1">MKLINIGFGNMVVSSRIVAIISPDSAPIKRFLSDAKTRNELIDATYGRKTRAVLVLDSGHIVLSALHPETIAARIEGGDKEEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Y8</accession>
    <name>B8E0Y8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583803.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353339.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1451"/>
    <dbReference type="EnsemblBacteria" id="ACK42725">
        <property type="protein sequence ID" value="ACK42725"/>
        <property type="gene ID" value="Dtur_1451"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1451"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_572039_0_0_0"/>
    <dbReference type="OMA" id="YSIHITA"/>
    <dbReference type="OrthoDB" id="141721at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="477" mass="55128" checksum="6609670D940BE09A" modified="2009-03-03" version="1">MNILKRLCFLNLWEQIISHNKKYKVSCFTLGYLYIDKTRKEFLEIPDGKLEKENLLGGYAYGNLEYPIVRVEEEKDIKENEIYALTISQDGKKYPGIIIRNYSRGKVMYVNLPLGHLKAYADDFPIRTFLRVFLFKILKIPHLLNTPYGIGGIVINWHVDSSIDWKSIPYMLQNNYLRKGIEYSIHITAGDFRDKQGDKLGFDACGEGKKYVKMILNFGVIGSHGGGAHNFFSDNILKGIFGEKEIYEYILRNNECLENITNYKILEYSAPNGVHPQPITTKVLEKLGMLCYYYTGDNGSSPNRTFINGKMVSHKVIAFPISSFGKYASFLEVKKGGKTEDEVKRWLFSIVYYVVKNRTLRLIYSHPYDIPLYPNALREFWDYVNTLKNKGIIQVKPMSYFATLLLRFLNTKYSINFSNKRITIVNKEGLEGITLALPKDFVIKDLPYGVTLKEEEGYQYITITKAFSANKLDIFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Z0</accession>
    <name>B8E0Z0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353341.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1453"/>
    <dbReference type="EnsemblBacteria" id="ACK42727">
        <property type="protein sequence ID" value="ACK42727"/>
        <property type="gene ID" value="Dtur_1453"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1453"/>
    <dbReference type="HOGENOM" id="CLU_2057653_0_0_0"/>
    <dbReference type="OrthoDB" id="1557194at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="119" mass="13836" checksum="DA8C0351B1549423" modified="2009-03-03" version="1">MLLITLIFLLFLLFPFLPSIKEYLNPRDILPLPIDFNYSRNPRYFSESFKRKLHETIKIEDVLKALDGTGILDFHGEDIKIYHIDSIPSGMELNKIIYMLGDLKTGENVTIKGECFLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E105</accession>
    <name>B8E105_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Chromosome segregation and condensation protein ScpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583820.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353356.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1468"/>
    <dbReference type="EnsemblBacteria" id="ACK42742">
        <property type="protein sequence ID" value="ACK42742"/>
        <property type="gene ID" value="Dtur_1468"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1468"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1259766_0_0_0"/>
    <dbReference type="OMA" id="YFYDDSW"/>
    <dbReference type="OrthoDB" id="2114360at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="219" mass="26331" checksum="126E4F3D3798E2D8" modified="2009-03-03" version="1">MIINPFITIKEMLQREVDISLFPLKNLVDQYSSLGEEKWKDLELTTSFLDVTLELLEGKIRKLFNKKADLKIEEEEEVSYFYDDSWRDLVEYLREKEERSLLIFRREKKEEIELTPEKKVNIAEIYFLFLEKKNSLILNLSYLDEDYDLDFEEKYKEILSKKEGRFSELIRKKPLLDAIGYFLVLCDMSNKNEVILKQEEFLGEIYFKVKIYEGNKANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E113</accession>
    <name>B8E113_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">MEP cytidylyltransferase</fullName>
            <shortName evidence="7">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispD</name>
        <name evidence="8" type="ordered locus">Dtur_1476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583828.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353364.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1476"/>
    <dbReference type="EnsemblBacteria" id="ACK42750">
        <property type="protein sequence ID" value="ACK42750"/>
        <property type="gene ID" value="Dtur_1476"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1476"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1525"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_2_2_0"/>
    <dbReference type="InParanoid" id="B8E113"/>
    <dbReference type="OMA" id="ERQHSVY"/>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="231" mass="26563" checksum="D6F3476391E47D73" modified="2009-03-03" version="1">MEKITGIIVAAGKSKRFGEDKLLIDIKGMPIVYYSLRKLNDIEDLERIILVVREEMVEYYKKKISNWGLEKIYKIIPGGEERQNSVYNALKSINFSCDYILIHDAARPLISTKKIKELIDFCTEKKVSAILGIPVRDTIKVVDKNSKKVIETLDRSKLWLIQTPQMFPFEIIKKAHEKAVEDNFIGTDDASLVERLNIPVYIVEGDPLNIKITTKDDLLWIEGIIQKLELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E123</accession>
    <name>B8E123_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="8">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">argS</name>
        <name evidence="12" type="ordered locus">Dtur_1486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583838.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353374.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1486"/>
    <dbReference type="EnsemblBacteria" id="ACK42760">
        <property type="protein sequence ID" value="ACK42760"/>
        <property type="gene ID" value="Dtur_1486"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1486"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1535"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_0_1_0"/>
    <dbReference type="InParanoid" id="B8E123"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="1146366at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="10">
        <location>
            <begin position="430"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="550" mass="63750" checksum="2E7E0AB8826429E2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E132</accession>
    <name>B8E132_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cellulase</fullName>
            <ecNumber evidence="9">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583847.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353383.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1495"/>
    <dbReference type="EnsemblBacteria" id="ACK42769">
        <property type="protein sequence ID" value="ACK42769"/>
        <property type="gene ID" value="Dtur_1495"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1495"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_0_2_0"/>
    <dbReference type="InParanoid" id="B8E132"/>
    <dbReference type="OMA" id="FGWPAIH"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="353" mass="39095" checksum="3C6A91C0308C9B58" modified="2009-03-03" version="1">MSDLLNMLKEITEAPGVSGYEKGIREVLKKYLSEIAVLEEDRLGSLIFKKQGSKETPKVMLAAHMDEIGFMVKSITSNGFIKFLPLGGWWDQVLLSQRVIIHTQNGPIVGVIGSKPPHILSEEERKKVVEKKDMYIDIGANSEEEALNWGVRPGDPITPYSEFQVMHNPDFLLAKAWDDRVGCALLVEIIKELKNIDHPNTIYGAATVQEEIGLRGATTSSFVVNPDVAIILESDIATDVPGINEEKRIYLGKGPSIIIYDATMIPNSNLRRIFIETAEKLNIPIQYSALERGGTDGGRIHIHAKGVPSIVVGVPARYIHSHTSIINVKDFLNAKKLIVEVIKSLNKEIVESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8E142</accession>
    <name>B8E142_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583254.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352784.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0889"/>
    <dbReference type="EnsemblBacteria" id="ACK42170">
        <property type="protein sequence ID" value="ACK42170"/>
        <property type="gene ID" value="Dtur_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0889"/>
    <dbReference type="HOGENOM" id="CLU_805929_0_0_0"/>
    <dbReference type="OMA" id="KWWSENL"/>
    <dbReference type="OrthoDB" id="2109369at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="344" mass="39420" checksum="44C19C19C0FD1D63" modified="2009-03-03" version="1">MRKTILLLLVLVFILSPAFSQEWGNLELSTEVNSIYGQDYIFSAEKWWSENLGAGFSIFYNPSQNFSYKTFLQTPYLRFTLGEFYPKINLISENLQLKGFHLSFYLYNNEIFYMSGYGARKFPDLPYYTHLTNDVPLKILGWSLPIGENKYINLSLTSINDSQENYLIDASFLNKTSLPLGNIIIIQDASIFLKNSILYLSALNSTNLSIGSLSIKALFGYINPNTPSFYLLDPGDIGGIISLNLPLSSNLFPEYMLGYFYNVKKAEHKINLGINLGWNLSNYLNLTSSARYILSSKNNNWLYMQIALNFPTLEGTMWNSIYIKYEKSITQEDTSLGLRITYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E143</accession>
    <name>B8E143_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0890</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583255.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352785.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0890"/>
    <dbReference type="EnsemblBacteria" id="ACK42171">
        <property type="protein sequence ID" value="ACK42171"/>
        <property type="gene ID" value="Dtur_0890"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0890"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.928"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_3_4_0"/>
    <dbReference type="InParanoid" id="B8E143"/>
    <dbReference type="OMA" id="GLYTITM"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="261"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="454" mass="52769" checksum="8E63E1C994E5416D" modified="2009-03-03" version="1">MDKQRLDAFFLLILFILDLILLSLALTIAYNIRFNLLSKIRYFYVEPNEVPEFFPYYLGISIILTVLWIILLILNRVYSVKNIFSYYPVVNAITVGIFLVSSLSFFYREFSYSRLVFILAWGVALFLTFISRVILYIVRAVVLGRRLSRALIIGNNEFAKSIISSGKIRDYAEIEKDKIDFGELESFVDQRNIQEIIVTGEISDDELLKLISLKRKRSISIKIVPEGYLIFAKRISFDEISGIPILEIEISPLEGFQGYIKEIIDFLLGTLALILFSPLFLIIALLIKLDSPGPIFYKHLRAGRYGKPFYLWKFRTMYKDADKILDKYPELKREFEKEFKLKNDPRVTKVGKFLRKFSLDEIPQIFNILKGEMSVVGPRPVTFKELEKYGEYAEEILRVKPGLTGLWQVSGRSDVDYSQRIKFDLYYIQNWSILLDIKIILKTIPSVLLGKGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E165</accession>
    <name>B8E165_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fe-S cluster domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0912</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583277.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352807.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0912"/>
    <dbReference type="EnsemblBacteria" id="ACK42193">
        <property type="protein sequence ID" value="ACK42193"/>
        <property type="gene ID" value="Dtur_0912"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0912"/>
    <dbReference type="eggNOG" id="COG2000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036585_0_0_0"/>
    <dbReference type="InParanoid" id="B8E165"/>
    <dbReference type="OMA" id="PSFYAQF"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045272">
        <property type="term" value="C:plasma membrane respiratory chain complex I"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S" evidence="6">
        <location>
            <begin position="364"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="443" mass="50706" checksum="64BD8D3A65933850" modified="2009-03-03" version="1">MSEKYIHSVAINLQRCRGCIHCIRHCPTEAMRVRNGKSLIIPYRCIDCGECIRVCPYHAPFGFTHTLDSIAYLDNIVVIISPEFYSQFSTKYSVGDIQEAVRKVTNAKEVWDTTYAIYLLENALLDYVNSSHNLPLISTYCPAIIELIQVRFPTLIPNLSPFKSPIEIMGQIIREYWSKNYSNEKLNLVYITPCPALASYLKENKEEGVDFVIGIDNIYLRVKKELQENKSEILKLFYPKGILCGTLGGESQIFNEEEAISVGGIEKVVKVLEDLERNKIQEIKFLELRACEEGCVGGVLNPENYYLAKKRMHSIYKNLDKEKIENTNLLKDIAEVHISKIVRMSPISPRPIWKLDEDINKALKKMDEMKKILQILPGLDCGSCGAPTCASLAEDIVRGNAQVYDCIFLLKEKLWEMAKEMEELSRRSSSVILKRREEENEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E166</accession>
    <name>B8E166_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583278.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352808.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0913"/>
    <dbReference type="EnsemblBacteria" id="ACK42194">
        <property type="protein sequence ID" value="ACK42194"/>
        <property type="gene ID" value="Dtur_0913"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0913"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140224_1_0_0"/>
    <dbReference type="InParanoid" id="B8E166"/>
    <dbReference type="OMA" id="VTIQTHV"/>
    <dbReference type="OrthoDB" id="1675913at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="116" mass="12917" checksum="7035F3DEFEE545A9" modified="2009-03-03" version="1">MKISELINKLGLELIFPYDEDWEVENGIVCDLLSFVMANAPENSVWVTIQTHVNTIAVATLAGIKAIIFVSGQKPDEETIKKAKEENIILARTEDTAFNIVGKLYELGIKGVKRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8E197</accession>
    <name>B8E197_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Acyl carrier protein</fullName>
            <shortName evidence="7">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">acpP</name>
        <name evidence="11" type="ordered locus">Dtur_0944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 9">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583309.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352839.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0944"/>
    <dbReference type="EnsemblBacteria" id="ACK42225">
        <property type="protein sequence ID" value="ACK42225"/>
        <property type="gene ID" value="Dtur_0944"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0944"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.981"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_0"/>
    <dbReference type="InParanoid" id="B8E197"/>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1 7 8" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="7 8">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="79" mass="9049" checksum="FEF7E2846DF43264" modified="2009-03-03" version="1">MDESTIFEKVKKIIVDQLRVDENLVTMDSNIQEDLGADSLDAVELIMALEEEFGIDVQDEEAENFKTVGDVVRYIEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1C4</accession>
    <name>B8E1C4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0972</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583336.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352866.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0972"/>
    <dbReference type="EnsemblBacteria" id="ACK42252">
        <property type="protein sequence ID" value="ACK42252"/>
        <property type="gene ID" value="Dtur_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0972"/>
    <dbReference type="eggNOG" id="COG2270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040020_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1C4"/>
    <dbReference type="OMA" id="FGFHRMM"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="3"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="388" mass="42588" checksum="AC155CBD0A03E863" modified="2009-03-03" version="1">MWNVIITGITSFLTDVSSEMFYPLISFYLLALGAGPAILGIVEGLAESIASLLKVYSGYVSDKIRKRKPITILGYSLSAIGKLFLYFANSWIGVFIGRISDRFGKGIRTAPRDALIAESVPENRGRAFGLHRTMDTLGAFLGVLLSILIIKSLNLPEASSNLSSYIPTFKTIILISLIPAILGVLVLFLVKETTPSRALNEKKRIKFQWKALDRKLKGFLIISLIFTLGNSSNQFLFLRSQNLGASLLDVLFLYLLYNLVYTIFSYPAGFLSDKIGRKRIIILGYIFYGLVYFGFGIASKFSQLWLLFTLYGLYTAFTEGVEKALISDLSPAHLRATVIGLHATLVGIGLFPASFIAGLLWSILGPQAPFIFGGIMGIGAAIGLMFIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1F6</accession>
    <name>RL36_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmJ</name>
        <name type="ordered locus">Dtur_1004</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012548601.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352898.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1F6"/>
    <dbReference type="SMR" id="B8E1F6"/>
    <dbReference type="STRING" id="515635.Dtur_1004"/>
    <dbReference type="EnsemblBacteria" id="ACK42284">
        <property type="protein sequence ID" value="ACK42284"/>
        <property type="gene ID" value="Dtur_1004"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1004"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1041"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_0"/>
    <dbReference type="InParanoid" id="B8E1F6"/>
    <dbReference type="OrthoDB" id="2066169at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000196189" description="50S ribosomal protein L36">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <sequence length="37" mass="4327" checksum="5A7D30707D8DAB08" modified="2009-03-03" version="1">MKVRSSVKKICEKCKIVRRGGRVFVICENPRHKQKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1H3</accession>
    <name>B8E1H3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0167</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582583.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352112.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0167"/>
    <dbReference type="EnsemblBacteria" id="ACK41498">
        <property type="protein sequence ID" value="ACK41498"/>
        <property type="gene ID" value="Dtur_0167"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0167"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.173"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1H3"/>
    <dbReference type="OMA" id="HAMSHQV"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="8"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="369" mass="40581" checksum="796A56A370FF3BB7" modified="2009-03-03" version="1">MANILEIPKKVIYGRGSISVIGSELKKIGNKFLFLTGKSSLKKSGHLDKIVEEVKKYDLEVIVITGIPSEPNVDVVYQICDKITGNNFDGIVGIGGGSVMDMAKIIAFRLKTKLNPIDAKGKEVEDALPIIAIPTTSGTGSEATKFAVITDDVVKDKFIIMGSALIPTLTIIDPELTFTMPPLVAASTGIDAFSHAIESYLSRNSTPIVEYFSKSAIVDIYNFLPEAVLNQLESAKERMAYAAFWAGVAINNTKTTLVHAMSRPLGGIYKIPHGIANGILLPAYLRFNAPFISDEKYKFLKNTLGGDPPEKVEELLKKLNLPTKISQVVREKIDLDLLVKRTLEAKFNVENNIRPVKEEDVYNLFYEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1J7</accession>
    <name>B8E1J7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0193</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582607.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352136.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0193"/>
    <dbReference type="EnsemblBacteria" id="ACK41522">
        <property type="protein sequence ID" value="ACK41522"/>
        <property type="gene ID" value="Dtur_0193"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0193"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.199"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1J7"/>
    <dbReference type="OMA" id="PGPNMLA"/>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="176" mass="19343" checksum="CBEEDE938342388C" modified="2009-03-03" version="1">MGIYGALIRVFFKIGLFGFGGGYAIIALIRHLVVIQEKWVNDLQFIDIVAISQVTPGPIAINAATFLGYKMGGILGSLLATLSSVLAPFILVFFASYFVHNTNQEKYQKYLNLLSPVTFSLILAGTYGILKSSISDLWSTIIFIGAFILGYKYKLSLTKTLILSGLLGEIIYFLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1N1</accession>
    <name>B8E1N1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582641.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352170.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0227"/>
    <dbReference type="EnsemblBacteria" id="ACK41556">
        <property type="protein sequence ID" value="ACK41556"/>
        <property type="gene ID" value="Dtur_0227"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0227"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.237"/>
    <dbReference type="eggNOG" id="COG2403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046378_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1N1"/>
    <dbReference type="OMA" id="ECTIEER"/>
    <dbReference type="OrthoDB" id="414225at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="437" mass="50320" checksum="278A7E7E4626AC62" modified="2009-03-03" version="1">MKKVIIMGAGGRDFHNFNVIFKDNPQYKVVAFTATQIPGIENRIYPKDLAGDLYPDGIPIFPEEELPELIKRYEVDEVVFSYSDVSYNYVMQRASLVLSLGVDFRLLGTETMLKSKKPVVAICAVRTGSGKSQTTRYVVRVLRDMGLKTVVVRHPMPYGDFLRQKVQRFEKMEDLDTHECTIEEREEYEPHIRQKAIVYAGVDYKEILKEAESEADVIVWDGGNNDFPFYRPDLYITVVDPYRSGHELSYYPGEINLILANVVVVNKVDTAPKNKVQEVVENVRKRNKKCQIIYAKSPIRAEKEEDIKGKKVLVVEDGPTVTHGEMPFGAGYIFAREKGAIIVNPRDYAVGSIKEAYEKYTHLREVLPALGYSKEQLKELEETINKFDGEYVIIGTPIDLRRVINIKKKTIRIFYEYEDYGEKTLKDLIKEWWNNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1N2</accession>
    <name>B8E1N2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alanine racemase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582642.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352171.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0228"/>
    <dbReference type="EnsemblBacteria" id="ACK41557">
        <property type="protein sequence ID" value="ACK41557"/>
        <property type="gene ID" value="Dtur_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0228"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.238"/>
    <dbReference type="eggNOG" id="COG3457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067103_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1N2"/>
    <dbReference type="OMA" id="VGCFGGV"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="361" mass="40346" checksum="BF992B7BC8A978E6" modified="2009-03-03" version="1">MNICSPYLEINLPAIYHNAKVIVEKGKEQGILIDGVTKVSLGDPKIARVLVKAGVFGISDSRIESIKRMKEDGLDTQFTLIRLPCLSQVEEEIKYADVSLNSEFITLKALNEAGERLKKKHKVIIMVEMGDIREGIWNKEELYFVIGEVLKMENLELWGIGTNFTCFGGVIPTEEKYISFLEIVRDLEKRFNISFPMVSGGNSSSISLLFEGKIPSGINHLRIGEGIMLGRETSYRKPVLGARTDTFKFVGEILEIKEKPSIPWGIIGEDAFGHKPSFKVRGIRKRALLNFGRQDIDPEGLIPETFGIEILGATSDYTVVDISENDSLKVGDSISFSLNYSALLQAFTSPFVKKIYKEVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1N5</accession>
    <name>B8E1N5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582645.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352174.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0231"/>
    <dbReference type="EnsemblBacteria" id="ACK41560">
        <property type="protein sequence ID" value="ACK41560"/>
        <property type="gene ID" value="Dtur_0231"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0231"/>
    <dbReference type="HOGENOM" id="CLU_1127669_0_0_0"/>
    <dbReference type="OMA" id="WLVGAEN"/>
    <dbReference type="OrthoDB" id="2128593at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="246" mass="29080" checksum="4D9650885868EA8B" modified="2009-03-03" version="1">MRLWWITEFKFKINDKKYLKTELIYIFIIVILTLILWPSKTLDVNKYSIPDLFLIFSLSHFLFITYLSSLISSGNLLAEREFKTLSLVKYSDLSIPNIILGRVFSTLLYILYLFVILFPFNLIINFSGDISRIFMLYFLLILDTIPLIGLGALWSTFINPSLNWLFHWISYLVFIIIPFIFPSTFFLFPLNNILWLVGAENILYVSVNFDPPKHIPIIILFYLLIFLISILIAQKRLKYYKGEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1N7</accession>
    <name>B8E1N7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase associated with various cellular activities AAA_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582647.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352176.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0233"/>
    <dbReference type="EnsemblBacteria" id="ACK41562">
        <property type="protein sequence ID" value="ACK41562"/>
        <property type="gene ID" value="Dtur_0233"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0233"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_3_1_0"/>
    <dbReference type="InParanoid" id="B8E1N7"/>
    <dbReference type="OMA" id="DRFMFAI"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="39"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="325" mass="35976" checksum="4995E6DEF8BC0C8E" modified="2009-03-03" version="1">MALSLEDFTDVVGKIKKEVSKVIVGYDEIIDLTIIALLSGGHVLLEGVPGIGKTLLVKTLSEILNLKFSRIQFTPDLMPADITGTNIIVEDESGRKHFRFQEGPIFANIILADEINRATPKTQSALLEAMQEGSVTSGGNIYLLPKPFFVMATQNPIEMEGTYPLPEAQLDRFFFKLILTPPGEEELLEIIERTTNVEIPKVEKVADGNTIEALKQLVRSVPISTAVKEYAVRIVLATHPESKYATEKVKKYVKYGSSPRGAQALILGAKALSLFENRANVSFKDIKKVAIPSLRHRIILSFEGEAEGITPDEIIQNILEEIKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1W8</accession>
    <name>B8E1W8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582836.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352365.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0450"/>
    <dbReference type="EnsemblBacteria" id="ACK41751">
        <property type="protein sequence ID" value="ACK41751"/>
        <property type="gene ID" value="Dtur_0450"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0450"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.475"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1W8"/>
    <dbReference type="OMA" id="NHAMRDE"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="235" mass="26810" checksum="CA9020FA79CFCFEE" modified="2009-03-03" version="1">MKGLVVILLFSLFFVPSFAIQEYPKPDKLCALTFDDGPDARLTPRVLDKLEKYNVVATFFLVGQRINSSVKPVLDRMVAMGCEFGNHSWDYNPMDKMDPEMIKEYIKRTNETIQAYTGKVPQFFRPPNLAVSRTMFDVIDMPFVSGVLGFDWAGCDRTPENIANNVLKGIKDGAIILLHDVQPEPHPTPEALDILIPALKKMGYEFVTLTELFKRKGVDPKDPKYKYKLWVYVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Y9</accession>
    <name>B8E1Y9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-sulfur cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582857.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352386.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0472"/>
    <dbReference type="EnsemblBacteria" id="ACK41772">
        <property type="protein sequence ID" value="ACK41772"/>
        <property type="gene ID" value="Dtur_0472"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0472"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033147_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1Y9"/>
    <dbReference type="OMA" id="CPVGAFY"/>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="257" mass="29493" checksum="3DBAF49709F3B7C4" modified="2009-03-03" version="1">MKRRRFFSLRSLWQTISLIVVNSYFLAPWGKYIPVPVFNCYSCPLANFACPIGTLQHFIVLHKFPFFTLGVLFLAGILLGRFFCGWICPFGFIQDLLYKIPTKKLAIENKFATFIRWSIFIILVIIIPYITLEPWFCKLCPAGTLEAGIPQILLHPPLRSLIGFLFGIKILILIGFIISSIFISRPFCRFVCPLGTILSVFNKISFYHLEVKPTCPECSLCKPKCPINIEVYKDPNSPHCIRCHECFSCGQVKLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Z3</accession>
    <name>B8E1Z3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0476</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582861.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352390.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0476"/>
    <dbReference type="EnsemblBacteria" id="ACK41776">
        <property type="protein sequence ID" value="ACK41776"/>
        <property type="gene ID" value="Dtur_0476"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0476"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.502"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1Z3"/>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="66"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="276" mass="30182" checksum="3A82672EDD142FED" modified="2009-03-03" version="1">MSYKKRKAINKIMLFISILTFFIGAFFLFWILGDIFLKGVRYINFRMFLELPKPPGVPGGGIGNALLGTFILTLLASIIGIPLGIMVGVYVNEYGAGRLAWWTKFLAEVLTSFPTIIIGVFVYLVVVVPMKSFSALAGGIALSIIMLPIVAKAADESIKMVPISLREAAYALGVPKWRTILKVVIPSASSGIITGIMIAIARAMGETAPLLFTSLNNVYWSVSLTKPIGSLTVTIFNYATSPYDDWRHMAYASALVLVFIVLVLNIIARFYGGRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8E214</accession>
    <name>B8E214_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352411.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0504"/>
    <dbReference type="EnsemblBacteria" id="ACK41797">
        <property type="protein sequence ID" value="ACK41797"/>
        <property type="gene ID" value="Dtur_0504"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0504"/>
    <dbReference type="HOGENOM" id="CLU_3396221_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="31" mass="3455" checksum="DE1FF48B5B606684" modified="2009-03-03" version="1">MKRVLLILLILIVSLVFVSPSAEVVVIKYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E235</accession>
    <name>B8E235_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fimbrial assembly family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583395.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352926.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1032"/>
    <dbReference type="EnsemblBacteria" id="ACK42312">
        <property type="protein sequence ID" value="ACK42312"/>
        <property type="gene ID" value="Dtur_1032"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1032"/>
    <dbReference type="eggNOG" id="COG3166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081304_0_1_0"/>
    <dbReference type="InParanoid" id="B8E235"/>
    <dbReference type="OMA" id="FRIVAQY"/>
    <dbReference type="OrthoDB" id="1673053at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="184" mass="21339" checksum="4F92F667503D299B" modified="2009-03-03" version="1">MFRINLLPKEVKKKEPIRLPFLGILITVVGLILLLGEVILYFNLSSEVTNLRNENTSLEFQINDLKSKINELQRLQSIKTQYEEKLRLVDEISKREISWLDLFETLNRITPKNLWVKSFNLDSSDNINIEGFALNYKEIAIFLDQLDKSDLVKNVSLGFAQKVGEPPLVSINFRIVAQYKRGEQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E247</accession>
    <name>DXS_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="1">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate synthase</fullName>
            <shortName evidence="1">DXP synthase</shortName>
            <shortName evidence="1">DXPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxs</name>
        <name type="ordered locus">Dtur_1044</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583407.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352938.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E247"/>
    <dbReference type="SMR" id="B8E247"/>
    <dbReference type="STRING" id="515635.Dtur_1044"/>
    <dbReference type="EnsemblBacteria" id="ACK42324">
        <property type="protein sequence ID" value="ACK42324"/>
        <property type="gene ID" value="Dtur_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1044"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1081"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_0"/>
    <dbReference type="InParanoid" id="B8E247"/>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000119544" description="1-deoxy-D-xylulose-5-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="145"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <sequence length="618" mass="68297" checksum="B99584B8336C50BA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E278</accession>
    <name>B8E278_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="8 9">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">miaB</name>
        <name evidence="13" type="ordered locus">Dtur_1076</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="8 9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583438.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352969.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1076"/>
    <dbReference type="EnsemblBacteria" id="ACK42355">
        <property type="protein sequence ID" value="ACK42355"/>
        <property type="gene ID" value="Dtur_1076"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1076"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1112"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_0_0"/>
    <dbReference type="InParanoid" id="B8E278"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035597">
        <property type="term" value="F:N6-isopentenyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035600">
        <property type="term" value="P:tRNA methylthiolation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="142"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="374"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="441" mass="50895" checksum="A7EFD7F1F7A2F855" modified="2009-03-03" version="1">MPKYHIITYGCQMNKSDSEKVAGILESLGYIPSEKMEEADLILLNTCSVRERAEEKVFGKLGELRKLKKKNQKLLIGIFGCMAQRMKEELIEKFPHVDFVLGSYKFTELPKVLESLNDNNKKIVLAEDNPKPEEVDFRIIRRENKFQAWIPIIYGCNNFCTYCIVPYLRGKEKSRDPQEIIKEIEHLANQGVVEVTLLGQNVDSYGKDLGNVDLADLLVEIHKIPGIKRIRFLTSHPRDVSDKLINVVATHPKICPHWHLPLQAGSDRILRRMGRGYTYNEYKALIEKIRAKIPRASFSTDIIVGFPGEEEEDFLATRRALEEIKFDTVNLAIYSKRPGTPAASYDDPVPYETKKKWFDELENLQRKIIYERNLSMIGKEELVLAEGVNPKNPKELSGRTENYRLVFFEADRKLIGKFLLVRIIEARLWSLRGEAIREVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E299</accession>
    <name>B8E299_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8 10">FAD:protein FMN transferase</fullName>
            <ecNumber evidence="2 8 10">2.7.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Flavin transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_1097</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>FAD + L-threonyl-[protein] = AMP + FMN-L-threonyl-[protein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36847"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11061"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:74257"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.1.180"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Magnesium. Can also use manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the ApbE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.180" evidence="2 8 10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583459.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352990.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1097"/>
    <dbReference type="EnsemblBacteria" id="ACK42376">
        <property type="protein sequence ID" value="ACK42376"/>
        <property type="gene ID" value="Dtur_1097"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1097"/>
    <dbReference type="eggNOG" id="COG1477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044403_1_3_0"/>
    <dbReference type="InParanoid" id="B8E299"/>
    <dbReference type="OMA" id="MGTYYSI"/>
    <dbReference type="OrthoDB" id="2021063at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017013">
        <property type="term" value="P:protein flavinylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024932">
        <property type="entry name" value="ApbE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30040">
        <property type="entry name" value="PTHR30040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02424">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006268">
        <property type="entry name" value="ApbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006268-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="339" mass="39639" checksum="6A6662346B876EC4" modified="2009-03-03" version="1">MSNQSSHFAKEIKILISFLFIGALFFLFIRNFDESREYYRNGILMDTFIEVRIWGRDGERALNECWENLEYLAKLLDRFSNNSDIYRINSKAGSWVKVAEDTLEIINKAIYYAKMTDGYFDPTIAPLLKLWGFYDKRYRIPTEDEVKRELRKVDFRRIQIREKMVFIPKGMEIDLGGIAKGYILDRLLSSLKRYKIERALLNIGGQIGVYGKPKDGNEWEIRIRNPRKLDDYIGLVYINKGSVATSGDYERYFIRDGIRYCHLIDPKTGYPVREVMSVSIISENATKADALSTAFFVMGAKAISYWEKFTDLGVVIVFSDGKIWYSPNIHFVKNEDYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2A5</accession>
    <name>B8E2A5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence protein ComEA helix-hairpin-helix repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583465.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352996.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1103"/>
    <dbReference type="EnsemblBacteria" id="ACK42382">
        <property type="protein sequence ID" value="ACK42382"/>
        <property type="gene ID" value="Dtur_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1103"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1139"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052011_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2A5"/>
    <dbReference type="OMA" id="MVDIKGA"/>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004509">
        <property type="entry name" value="Competence_ComEA_HhH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00426">
        <property type="entry name" value="TIGR00426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="187" mass="20646" checksum="3DB6F692AADE7FA9" modified="2009-03-03" version="1">MFEKKEKFLLVIFVVILVGVLFSMVSNLSGGNNIDVDKNEFIIVHITGEVKNPGVYKLEEGARVIDAINLAGGSLPSADLDKVNLADFLRDGSKIYIPSKLENSENELKSQAILSTRKIDTSKSDKVNINTASKEELESLPGIGPTLAQRIIEYREENGPFGSAEDLLNVKGIGEKKLERIRDQITW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2A8</accession>
    <name>RS20_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsT</name>
        <name type="ordered locus">Dtur_1106</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352999.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2A8"/>
    <dbReference type="SMR" id="B8E2A8"/>
    <dbReference type="STRING" id="515635.Dtur_1106"/>
    <dbReference type="EnsemblBacteria" id="ACK42385">
        <property type="protein sequence ID" value="ACK42385"/>
        <property type="gene ID" value="Dtur_1106"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1106"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1142"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_5_0_0"/>
    <dbReference type="InParanoid" id="B8E2A8"/>
    <dbReference type="OMA" id="GVIHKNA"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000126437" description="30S ribosomal protein S20">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <sequence length="93" mass="10680" checksum="D9117494ADB434BA" modified="2009-03-03" version="1">MANTKSAIKRIKISERNRIRNRVRLGKIKFYTKQFLKFLNENNIEEAKKILPEVISAIDKAAQKGTLHKNTAARKKSKLMKLLNQKLSANLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2B3</accession>
    <name>B8E2B3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583473.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353004.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1111"/>
    <dbReference type="EnsemblBacteria" id="ACK42390">
        <property type="protein sequence ID" value="ACK42390"/>
        <property type="gene ID" value="Dtur_1111"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1111"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1147"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_2_3_0"/>
    <dbReference type="InParanoid" id="B8E2B3"/>
    <dbReference type="OMA" id="MCLGFLP"/>
    <dbReference type="OrthoDB" id="728505at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044038">
        <property type="term" value="P:cell wall macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="340" mass="37709" checksum="BA0605FB51800BAB" modified="2009-03-03" version="1">MNVFFAFLLSLVISVLLTPWVKKIAYQVGAVDIPNDRKVHLKPIPRIGGVAFFLSILVVNVIFNKSPVVEKIIFGGLLVFLVGLLDDFVELKPKPKFWLTFLAVLIAVILGVRVEIWRVPYTKIIIKGFWADVITFVWLLGITNAMNFIDGLDGLAGGVSVISSFSLLIISLILGRIEMALLLSSILGAVLGFLFYNFPPASIFMGDSGAMFLGFILGAISVIGVLKISTVINLFFPIIVLGFPVLDTAFSIIRRILEGRAPWRYDKDHIHHRFLRLGMSTEQSIAFIYLITICMALLAVIISLLQDPYISAILLFGTLFLIIFILKKLGVLEVRKNGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2J2</accession>
    <name>B8E2J2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583911.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353450.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1562"/>
    <dbReference type="EnsemblBacteria" id="ACK42836">
        <property type="protein sequence ID" value="ACK42836"/>
        <property type="gene ID" value="Dtur_1562"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1562"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1611"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_0"/>
    <dbReference type="InParanoid" id="B8E2J2"/>
    <dbReference type="OMA" id="NCVAPMA"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="154"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
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        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="337" mass="36816" checksum="5AC51E0A8381CD69" modified="2009-03-03" version="1">MAVKVGINGFGRIGRQVLKALFERHGDKVEVVAVNDITDTKTLAHLFKYDSNYGVYKGEVKYTDKSIIIDGKEIRVFAEKDPANLPWKDLGVDIVIESTGLFTDADKAKVHMTSGGAKKVIISAPAKGEDITIVLGVNEEKYDPEKHHIISNASCTTNSLAPVAKVLLDNFGIEKGLMTTVHSYTNDQRILDLPHKDLRRARAAALNIIPTSTGAAKAIGRVIPELDGKMHGVALRVPTPTVSVTDLVCLLQKNVTVDEVNEAFKKAAEGRMKGILGVTEEELVSMDFKGTTYSTVVDLPSTIVIGNNLVKVFAWYDNEWGYACRLADLTAYVAERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2R6</accession>
    <name>B8E2R6_DICTD</name>
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        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ordered locus">Dtur_1137</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
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            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="ACK42416">
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    <dbReference type="PATRIC" id="fig|515635.4.peg.1174"/>
    <dbReference type="eggNOG" id="COG1173">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="BPD_transp_1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="133"/>
            <end position="151"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="212"/>
            <end position="239"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
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            <begin position="91"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="293" mass="32199" checksum="68DD1D8FBF4117F0" modified="2009-03-03" version="1">MAAKAKALKEDRKPRSLWRIAWKRLSKNKLALLGLGIVIFFVIIALFAQYLTPYSWNAVDLSNALQPPSWEHPLGTDEFGRDILSRIIYGTKISLQFAFFAQLISISLGTVLGLIAGFYGGWIDDLIMRIVEILFAFPFLLFVIAVVSTLGTGIQNLYIAVAIIGWAGVSRIVRGQVLSLRERDFVASAQAIGASTWRILFRHILPNALSPIIIETTIGMGGMIMLEAGLSFLGLGVQAPTPSLGSMVQAGLAYLRSCWWYPIAPGLVIMIIVFGFNLLGDGLRDALDPRLYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2T8</accession>
    <name>B8E2T8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">der</name>
        <name evidence="11" type="ordered locus">Dtur_1159</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353052.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1159"/>
    <dbReference type="EnsemblBacteria" id="ACK42438">
        <property type="protein sequence ID" value="ACK42438"/>
        <property type="gene ID" value="Dtur_1159"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1159"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1196"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_0"/>
    <dbReference type="InParanoid" id="B8E2T8"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="6"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G" evidence="10">
        <location>
            <begin position="178"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="184"/>
            <end position="191"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="231"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="436" mass="49665" checksum="84E048775EFF562C" modified="2009-03-03" version="1">MKKGVPVVSIVGRPNVGKSVLFNRIVGEEKAIVADEPGVTRDPLVHLCEHEGKYFYLVDSAGWGLTDDLSELIQEKIQEVINISDLILFVVDGRSELTALDHEFVDILRKSGKRVILVVNKMEGRIDREEYLAPFTALGLGEPFPISALHKQNLYELLDLIISLIPAPEEVSSEDKSIKLAFVGRPNSGKSSLLNALIGRDRSIVSEIPGTTRDAVDLIWDFNGKKYIIVDTPGLRRPAKVEEGLEELSVQKTLQTIRRIDIAIMVIDLSVGIREQEKRILHYIEDKGKSCLIVFNKTDLIPSLKERREFEKIVPQILQPFDYFPFIFTSAIRNYNVKKILPWVDKLFELRNMRIPTSQINRAIGEALSKTNFSKKGKILKIYYATQVDVAPPTIVFFVNEPEIMNKNVVKYFEKFLRNYFGWVGTPIKIEVRKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E305</accession>
    <name>B8E305_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583587.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353119.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1227"/>
    <dbReference type="EnsemblBacteria" id="ACK42505">
        <property type="protein sequence ID" value="ACK42505"/>
        <property type="gene ID" value="Dtur_1227"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1227"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1266"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_0"/>
    <dbReference type="InParanoid" id="B8E305"/>
    <dbReference type="OMA" id="PNEAPRI"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="253" mass="29569" checksum="EABF4BD6464D5C1F" modified="2009-03-03" version="1">MWTDTHVHLNDERIYPQWREYVERAKKNGVVSFFVVGYDWESSLRANHLSIFEGIYSIIGVHPHESSSPYVDELDWKSLVTEKTLAIGEIGLDYYRLHSPKEKQKEVFSRFIQFAKEVNRPIVIHCRDAWKDLIDIMKAEKVWEVGGIMHSYSGSYETFKLVSEWNFLFSFSGPITYPNAKNLREVLKKIPLEYIVIETDAPYLPPQSCRGKMNEPAYLPEIAEKISELKNVSLEDLSIKFRENLKNLFGKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E312</accession>
    <name>B8E312_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan glycosyltransferase RodA</fullName>
            <shortName evidence="6">PGT</shortName>
            <ecNumber evidence="6">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell elongation protein RodA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Peptidoglycan polymerase</fullName>
            <shortName evidence="6">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rodA</name>
        <name evidence="7" type="ordered locus">Dtur_1234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Peptidoglycan polymerase that is essential for cell wall elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEDS family. MrdB/RodA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583594.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353126.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1234"/>
    <dbReference type="EnsemblBacteria" id="ACK42512">
        <property type="protein sequence ID" value="ACK42512"/>
        <property type="gene ID" value="Dtur_1234"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1234"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1274"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_2_0"/>
    <dbReference type="InParanoid" id="B8E312"/>
    <dbReference type="OMA" id="TGMAMPF"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02079">
        <property type="entry name" value="PGT_RodA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="366" mass="42280" checksum="49D66655BC36430A" modified="2009-03-03" version="1">MKRREIKLILVVILLTFIGFLFIYDTTATRLIAKELSPYVFLQRQVIAFLIGLVFFAFFATTYYRLWERVWKYVYVINLFLLVMVIFFGKESLGAQRWFSIFGFSFQPSELSKLLLVISLSGFLTNLDYEKKTLGLREFILTLVLVIIPFIVVMIQPDLGTAIVIFATGIFMIFLSEISVKYFLRLILLGLLLLPFFWLILKPYQQQRIITFLDPMKDPLGSGYQVIQSLIAIGSGGIWGKGWFQGTQTHLNLIPEQHTDFIFSAIGEEFGFIGSLFVVFLYYLLFRYTWEIWGSLKDKFGKYIVGGILFCWFFQTFINLCMVSGISPVVGIPLPFISFARTSLITNYAMLGLIVNIYVRGERQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E318</accession>
    <name>B8E318_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583600.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353132.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1240"/>
    <dbReference type="EnsemblBacteria" id="ACK42518">
        <property type="protein sequence ID" value="ACK42518"/>
        <property type="gene ID" value="Dtur_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1240"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1280"/>
    <dbReference type="eggNOG" id="COG1496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065784_0_2_0"/>
    <dbReference type="InParanoid" id="B8E318"/>
    <dbReference type="OMA" id="FYADCLP"/>
    <dbReference type="OrthoDB" id="1393323at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="237" mass="28304" checksum="A03D9A71F5B013BD" modified="2009-03-03" version="1">MIWRSKLLSEFSEISHGFVSYPFSFPFKFGFRYLYNYLRFFFLIKVPSGNWIFADQVHGDKIYLVKKEVNKIFPKIAYKTDALLSLERKRPLIMFFADCMPIYIYVPKIKLVGLVHSGWRGTIRDFPLKVIKHIKESYSIESKEILISVGPSIHSCCFEVKEDFISQLPKEYKKFIITRNHKTFYDLVELVNYQFKKENIPDSNIEISHICTFCDKNFYSFRRDRNSNRNLGYIFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E323</accession>
    <name>B8E323_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="16">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">murB</name>
        <name evidence="18" type="ordered locus">Dtur_1245</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="16"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353137.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1245"/>
    <dbReference type="EnsemblBacteria" id="ACK42523">
        <property type="protein sequence ID" value="ACK42523"/>
        <property type="gene ID" value="Dtur_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1245"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1285"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_1_1_0"/>
    <dbReference type="InParanoid" id="B8E323"/>
    <dbReference type="OMA" id="MQNIGAY"/>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 16" id="KW-0133">Cell shape</keyword>
    <keyword evidence="15 16" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0274">FAD</keyword>
    <keyword evidence="8 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 16" id="KW-0521">NADP</keyword>
    <keyword evidence="13 16 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12 16" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="17">
        <location>
            <begin position="30"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ACK42523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="297" mass="33686" checksum="2286A9E89662A353" modified="2009-03-03" version="1">MLIWNILNKYNFKSKIYKDVNLSHYTSFKIGGKVDLFIIPYSWEELILILQILKENNIPTKVMGQGTNILAPDEGIKGAVIRLNQNLGKINFVDNSHLEVESGCLISKLISFMVEKNMGGLEFMMGIPGTIGGAVMGNAGAFRKAIGDFVEGVYVLNEHFEEMFLGKKELNFNYRSSNIPKDWIIKKVLLRLEEKPKEESLKEIKFFIKERSKKLPKYPSAGSVFKNPKEGPAGYFIDNLGFRGFRIGDAMVSYEHANTIINVGRARSKDVLEIINIIKDKVKEAYGIDLEPEIIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E349</accession>
    <name>B8E349_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583998.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353537.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1650"/>
    <dbReference type="EnsemblBacteria" id="ACK42923">
        <property type="protein sequence ID" value="ACK42923"/>
        <property type="gene ID" value="Dtur_1650"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1650"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1699"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_1_0_0"/>
    <dbReference type="InParanoid" id="B8E349"/>
    <dbReference type="OMA" id="AYAEFVH"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="170" mass="19615" checksum="5627DB5A54E86D6F" modified="2009-03-03" version="1">MRKMTEEFLHNAFAGESMAHMKYLIFAEEAERKGLVKLANLFRAIAYAEFVHARNHFRELGLLKQDMPDNVQQCIDGETYEIEEMYPVYNNTAVFQNEKGAERSTRFAWEAEKIHAEMYKKAKELVSKNEDYTATKIYICPVCGHTIEGEPPEKCPLCGAPKSSYKEFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E379</accession>
    <name>B8E379_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Periplasmic solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584028.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353567.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1681"/>
    <dbReference type="EnsemblBacteria" id="ACK42953">
        <property type="protein sequence ID" value="ACK42953"/>
        <property type="gene ID" value="Dtur_1681"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1681"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_0"/>
    <dbReference type="InParanoid" id="B8E379"/>
    <dbReference type="OMA" id="FHEAFDY"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="277" mass="32367" checksum="0C3325C063998A64" modified="2009-03-03" version="1">MKNKIWKLLIIVFLILSMSYPQEKNLAVSIYPIGSITKYIVGKLWNISILLPSNTNPHLFEPTSETMREIEKAKLVIINGKDVDIWAKKLADSAKKDVLVISDYLKVRESNPHFWLDPILVKDMAKIIYNKISTLDPSNKGYYLKNLNDFNKKIDELHKYIIKELSTFKNKKIIAYHPSFYYFFKRYNIEVLSYIEEGEGKEPSLKKILGIIEIIKRENIKYIVKEPFVNNPTLETIQKETGVKLVDMDPLGYNKDYFSLIKENVIILKVIFNEQNP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E391</accession>
    <name>SYC_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="1">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysS</name>
        <name type="ordered locus">Dtur_1693</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584040.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353579.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E391"/>
    <dbReference type="SMR" id="B8E391"/>
    <dbReference type="STRING" id="515635.Dtur_1693"/>
    <dbReference type="EnsemblBacteria" id="ACK42965">
        <property type="protein sequence ID" value="ACK42965"/>
        <property type="gene ID" value="Dtur_1693"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1693"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1744"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_0"/>
    <dbReference type="InParanoid" id="B8E391"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000199061" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="279"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <sequence length="465" mass="54533" checksum="BC0D31AE05219BD8" modified="2009-03-03" version="1">MELYLYNTLTRRKEKFEPLNPPYVGMYTCGPTVYNYAHIGNLRTYIFEDILKRVLLYNGYIVKHVMNITDVGHLTSDADEGEDKIEREAKKERRTAWEIAEFYTEAFKRDIKKLNILEPDIWCKATDHIKDFIDLILILEKKGYTYKTSDGIYFDTSKVPDYGKLAGQDLENLLPGARVEYNPEKKNPTDFALWKFSPKDVKRQMEWDSPWGIGFPGWHIECSAMSTKYLGQPFDIHCGGIDHIPIHHTNEIAQSEAAYDKPMAKYWLHGEFLVMGEKRMGKSEGNFITLSDLEEKGYHPLSYRYFCLTAHYRSPLRFTWTALESAQRALFRLYENMKRYPQENASYDKKYEEEFHKAINDDLDMPKALAITWELVKDDQVPPEVKRATLLQFDKVLGLSLNNPPEIKIEIPEEIWKLVEERELARKNKDWEKADKIREEIRNKGYIIEDTPQGPRVKKATPLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3B1</accession>
    <name>B8E3B1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen decarboxylase (URO-D)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584060.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353599.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1713"/>
    <dbReference type="EnsemblBacteria" id="ACK42985">
        <property type="protein sequence ID" value="ACK42985"/>
        <property type="gene ID" value="Dtur_1713"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1713"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_2_0_0"/>
    <dbReference type="InParanoid" id="B8E3B1"/>
    <dbReference type="OMA" id="ATPNIEP"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="349" mass="39699" checksum="C8E5FA8E1B7A6DCC" modified="2009-03-03" version="1">MKDKEWQILLDCVNMKEPEEIPIALIVDSPWIPGYLGIPHMQFYFIPDVWLEAYKEIKRRFPEVIFIPDFWVEFGMAQEPSAFGAKIVFKPNATPNIEPILSSADDLPTFIARLKTPNPKTDGFMPIVLEYYKYIEPKVKGMGEKIKIVAARGPLAISSHLMGVTEFLVSVKLYPEEAKRLIEIATNLVIDFLTAQIEVLHDVEGILVLDDIVGFFSEEDYLEFAHPYLKKIFSSFDYPVKIYHNDTNNNVYYKYLPELGINIFNFTHLQNIKDVYNLTQGKMCLMGNVPPLDVLVNGSKEDVKRVVEKILMDYGMKKGLLLSAGGGVSPGTPGENIRAMIDTSRSFKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3B2</accession>
    <name>B8E3B2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylan alpha-1,2-glucuronidase</fullName>
            <ecNumber evidence="9">3.2.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_1714</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolysis of (1-&gt;2)-alpha-D-(4-O-methyl)glucuronosyl links in the main chain of hardwood xylans.</text>
            <dbReference type="EC" id="3.2.1.131"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.131" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584061.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353600.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8E3B2"/>
    <dbReference type="STRING" id="515635.Dtur_1714"/>
    <dbReference type="CAZy" id="GH67">
        <property type="family name" value="Glycoside Hydrolase Family 67"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42986">
        <property type="protein sequence ID" value="ACK42986"/>
        <property type="gene ID" value="Dtur_1714"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1714"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1765"/>
    <dbReference type="eggNOG" id="COG3661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007125_1_0_0"/>
    <dbReference type="InParanoid" id="B8E3B2"/>
    <dbReference type="OMA" id="DNNGWGQ"/>
    <dbReference type="OrthoDB" id="207695at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033939">
        <property type="term" value="F:xylan alpha-1,2-glucuronosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="SSF55545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="Glyco_hydro_67N" evidence="10">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67M" evidence="12">
        <location>
            <begin position="133"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_67C" evidence="11">
        <location>
            <begin position="460"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="685" mass="79447" checksum="718B67BDF21F21B9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYI8</accession>
    <name>B8DYI8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582456.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351984.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41370">
        <property type="protein sequence ID" value="ACK41370"/>
        <property type="gene ID" value="Dtur_0032"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0032"/>
    <dbReference type="HOGENOM" id="CLU_993007_0_0_0"/>
    <dbReference type="OMA" id="CIEVYEN"/>
    <dbReference type="OrthoDB" id="2108788at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="279" mass="31450" checksum="C53225B830F80073" modified="2009-03-03" version="1">MKKLLILLISLIVILSLSYAKSSELKLIGIAIAENIGEDEYGLTTIDGLFSIIHFEDLPATDTFPVYSRWMGYGKHHIEISIVTPTKDKVLASTEDNFELKNNNEVIYSFGYLKDVAFEDSGVYWIQARANGKVIKEIPVFILKGEEDLNPEDFDANPIPIFSLPCIEVYENDHGLTSLSGVFEYYTTSELPFEDTFIIANGFLSGEGNFTQRFEILSPSGKLIYSSEPQEFETNIGSIVTVTDNVEKLKFEEEGDYIVKVYLNDKEVLSHVIKVVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYM1</accession>
    <name>B8DYM1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582489.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352017.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0065"/>
    <dbReference type="EnsemblBacteria" id="ACK41403">
        <property type="protein sequence ID" value="ACK41403"/>
        <property type="gene ID" value="Dtur_0065"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0065"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.66"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_0"/>
    <dbReference type="InParanoid" id="B8DYM1"/>
    <dbReference type="OMA" id="KSHLMIP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="262"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="284"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="452" mass="52452" checksum="1858A19AD09D74E0" modified="2009-03-03" version="1">MNEEKILEYLKIISKIKEEEKNFENVEDFIFNIQNLLKKVSLKIFIEKNKITVSSENLENLDKKDNLFIHIITEDVNQFLEGKNYSNLFNELTISLIEQKNVEDLLDAILEKLEKIIPYTSANIALLENDALYYLSFRGYEKYGVEDFMRNFKMDKREFYTLKTVMETQKPLFVENTDEYPNWVIIPETQWIKSHLMIPIIYENKILGLISFDSDTPYGFKEEDIEKVYPLLPLLGIALENAKLYEKLKKELEERIIAEEKYKRSFYQIVKLASDIVEMKDPYTSGHQKRVARISVIIGKELGLSQEKIRALAISSLLHDIGKIGIPSEILNKPSSLNPLERRFINIHPEIGYNLLRKIEIISDIAPIVYQHHERINGSGYPKGLKGEEILLEAKIIGVADVFEAMTSHRPYRSALPIDMAIKELVENKGTLYDPDVVDAFLKSLKEGRIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYM3</accession>
    <name>B8DYM3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase</fullName>
            <ecNumber evidence="11">5.4.2.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0067</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582491.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352019.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0067"/>
    <dbReference type="EnsemblBacteria" id="ACK41405">
        <property type="protein sequence ID" value="ACK41405"/>
        <property type="gene ID" value="Dtur_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0067"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.68"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_9_1_0"/>
    <dbReference type="InParanoid" id="B8DYM3"/>
    <dbReference type="OMA" id="KCSQVMY"/>
    <dbReference type="OrthoDB" id="256504at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="7"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="159"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="267"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="387"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="475" mass="53483" checksum="AD86459FACBFB2C6" modified="2009-03-03" version="1">MITLDRTIFRMYDIRGEVPKNLNKDVARIIGKAYAIFIRKKTNKDTLTVSVGRDARISSKELSEGLIEGLRSSGINVIDIGLCPTPLLYFSLFTLPVDGGIMITGSHNPPQFNGMKICVGKETIYGPLIQELYEIALNLKDESSLKEGTYETHDIISSYKEFLLKEFQNSAITKLPQGTIKIVIDSGNGCGGLVAPDVLRKLGVDVIDLFSEPDGNFPNHHPDPTIMETLKTLRETVIKEKADFGVAYDGDADRIGIIDEKAEVVYGDRLAYIFAKGILKEHPGAKIIGEVKCSKFLFDGIEKLGGIPVLSPVGHSLIKKKLREENALFAGEMSGHIFFNDRFFGYDDAIYATMRLVELYAMEKLENPNFVFSDFLKEFPKVYASPEIRVHCSEEKKFEIIKNFFDKLKEKYPDTANKVQKVITIDGVRLEFDDGWALARASNTEPVIVLRFEANTEEKLKKYQEMFENIIKEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYM6</accession>
    <name>B8DYM6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582494.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352022.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0070"/>
    <dbReference type="EnsemblBacteria" id="ACK41408">
        <property type="protein sequence ID" value="ACK41408"/>
        <property type="gene ID" value="Dtur_0070"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0070"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_0"/>
    <dbReference type="InParanoid" id="B8DYM6"/>
    <dbReference type="OMA" id="YHQEERS"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="149" mass="18179" checksum="7F55AACBF4C7EBD5" modified="2009-03-03" version="1">MSDIISYFQVYGEKIYRYLRKLLREEEAAKDILQETFLRAMKTNIEEKTAKNYLFRIAHNLAIDYLEERNRFLDLDTEDKDEYDPEEIIEKKDIWKLLSPLEKSILILYYQEGYSYEEISEKLNIPLNTLKSHIYRAKKKIYNYLKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYT7</accession>
    <name>B8DYT7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582554.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352083.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0137"/>
    <dbReference type="EnsemblBacteria" id="ACK41469">
        <property type="protein sequence ID" value="ACK41469"/>
        <property type="gene ID" value="Dtur_0137"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0137"/>
    <dbReference type="HOGENOM" id="CLU_137927_6_0_0"/>
    <dbReference type="OMA" id="PKNIWEI"/>
    <dbReference type="OrthoDB" id="2073672at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="68" mass="7922" checksum="E111F61E2957A732" modified="2009-03-03" version="1">MKRKKPKNIWEIFNFTFALGTGLLGSLLVGIFIGYYLDKLFNTSPVFLLAFTVLGIWVGFRDIFRFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYU8</accession>
    <name>B8DYU8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OstA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582565.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352094.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0149"/>
    <dbReference type="EnsemblBacteria" id="ACK41480">
        <property type="protein sequence ID" value="ACK41480"/>
        <property type="gene ID" value="Dtur_0149"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0149"/>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281493_0_0_0"/>
    <dbReference type="OMA" id="VKITAQK"/>
    <dbReference type="OrthoDB" id="2114991at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017089">
        <property type="term" value="F:glycolipid transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015221">
        <property type="term" value="F:lipopolysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010664">
        <property type="entry name" value="LipoPS_assembly_LptC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026265">
        <property type="entry name" value="LptC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06835">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04409">
        <property type="entry name" value="LptC_YrbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867684" evidence="6">
        <location>
            <begin position="21"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="215" mass="24348" checksum="C1C2E86ED26B46CD" modified="2009-03-03" version="1">MKRLICILMIAILIMTSAFSQTKNPVKITAQKISYDYGKKTTRAEGNVVVIYKPGQDDETRITATLVFYNQDTNVVEAPGKVNISQRDLSIVGEDLKVDLKKETLELKKNVNMVLQRKVDNKVEITKLFSQSVVYSLKNKTGNMIGGVRIEREDLTVSANSADFDTDKEIYTFVDNVKMMDKDKNEINCKRLVVYVKDKVVVAEGNIDTTFYVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYV7</accession>
    <name>B8DYV7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582574.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352103.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0158"/>
    <dbReference type="EnsemblBacteria" id="ACK41489">
        <property type="protein sequence ID" value="ACK41489"/>
        <property type="gene ID" value="Dtur_0158"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0158"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8DYV7"/>
    <dbReference type="OMA" id="PRHTVYD"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="8"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="327" mass="37074" checksum="1096331107EFBB92" modified="2009-03-03" version="1">MNEQEYLLYVKDLTKVFIIGGRFLGVKLVAVNKESFSILKDRPEIFTIAGETGSGKTTLARMILGLLEPTSGEILYKGVNIAKLNSKKERKAFMKEVQPIFQNPFEAFNPLKRVDSYLYETAVNFGVANNKNDASEIVNRILEVVGLSLKEIEKRYPHELSGGQLQRVSIARALITTPSLLVADEPVSMVDASLRMSIVNLFKELKENLGISVIYITHDLATAYYISDRIAIMYRGNIVEMGPVEKVMLNPLHPYTKLLIASVPEADIDKKWTGEIKLSTQEVKEFTKLGCKFSERCDEREDICINEEPKKVFVDDRWVMCHKFVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYW3</accession>
    <name>B8DYW3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiamine pyrophosphate protein domain protein TPP-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582674.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352203.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0263"/>
    <dbReference type="EnsemblBacteria" id="ACK41589">
        <property type="protein sequence ID" value="ACK41589"/>
        <property type="gene ID" value="Dtur_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0263"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.276"/>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058423_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYW3"/>
    <dbReference type="OMA" id="ATGCMEV"/>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="2">
        <location>
            <begin position="48"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="311" mass="34467" checksum="FC252FA12B8CF559" modified="2009-03-03" version="1">MAINLRELALKEERLVSGHRLCAGCGASIVVRMVLNAIDEPVVVANATGCLEVATTIFPFNSWNVPWIHSAFENAAATIAGVEAAYRALKKKGEIDREIRFISFSGDGGTYDIGLQALSGAVERGHRAVFICYNNEAYMNTGIQRSSATPRGAFTTTSPAGKVVPGKPQRRKNLTEMMVANGARYVAQASPSHWRDLMEKVRKAVNTDGPAFLNIYSTCPRGWRTPDNSAINIARLAVETGVWPLYEVEDGKYKINYKPPKGFKPVEEFLKVQGRFAHLLKPENTHILEEIKKDIEAEWKRLLSMEEATNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYW7</accession>
    <name>B8DYW7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TrkA-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582678.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352207.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0267"/>
    <dbReference type="EnsemblBacteria" id="ACK41593">
        <property type="protein sequence ID" value="ACK41593"/>
        <property type="gene ID" value="Dtur_0267"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0267"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.280"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046525_3_2_0"/>
    <dbReference type="InParanoid" id="B8DYW7"/>
    <dbReference type="OMA" id="PEYEAGC"/>
    <dbReference type="OrthoDB" id="1768241at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="2">
        <location>
            <begin position="151"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="233" mass="26022" checksum="78140114967DD823" modified="2009-03-03" version="1">MKSLSYRLKRAGLDKTKLNSFAVIGLGRFGVAVATTLERMGFSVIAIDKDETKVEEIKDYVSYAKVLDSTNINALREAGVQNVDVAIVSIAHDVEASVLTALLVKELGVKFVISRAISEPHEKILERIGVDLVVYPERDMGVRLAQRLVVPNVIDYMEFSANIKIFEVEPPEPIIGKTIQELDLRKNYNLSIIAIQRGSEVIGNINPFERIQRGDILYIIGTFEDISKFLSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYX3</accession>
    <name>B8DYX3_DICTD</name>
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        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0273"/>
    <dbReference type="EnsemblBacteria" id="ACK41599">
        <property type="protein sequence ID" value="ACK41599"/>
        <property type="gene ID" value="Dtur_0273"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0273"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.286"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_3_0"/>
    <dbReference type="InParanoid" id="B8DYX3"/>
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    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="P:peptide transport"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="83"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="630" mass="73110" checksum="99B7A9D6DE8298D0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ85</accession>
    <name>B8DZ85_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582903.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352432.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0525"/>
    <dbReference type="EnsemblBacteria" id="ACK41818">
        <property type="protein sequence ID" value="ACK41818"/>
        <property type="gene ID" value="Dtur_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0525"/>
    <dbReference type="HOGENOM" id="CLU_2154346_0_0_0"/>
    <dbReference type="OMA" id="YQSNISR"/>
    <dbReference type="OrthoDB" id="1037688at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="113" mass="12802" checksum="DC736A3D024E2CBE" modified="2009-03-03" version="1">MIIEGYLEIFDLLMLISFLSYSNKSGILMLGVNHNEGVIFFNNGNIVDAFIDGKQGEEALMHLVLNYPVLSFSFYQGEILRENKINKSSEKLILELLKVFDEKNNKDILLVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZA4</accession>
    <name>B8DZA4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0547</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352451.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0547"/>
    <dbReference type="EnsemblBacteria" id="ACK41837">
        <property type="protein sequence ID" value="ACK41837"/>
        <property type="gene ID" value="Dtur_0547"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0547"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.583"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_0"/>
    <dbReference type="InParanoid" id="B8DZA4"/>
    <dbReference type="OMA" id="IMQRYPS"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="325" mass="37135" checksum="FE459BC34F03F950" modified="2009-03-03" version="1">MASIRDVAKRAGVTVTTVSRVLNNRGYISEETRKKVYKAMEELNYQPNELARALYRKRSYFIGLIIPDVSHPFFGEVAKYIEYYAYLRGYKILLCNSYLDEKKEKEYINMLKRHQVDGIIMGSHTLDVEDYKKVNLPIVALDRVLSEDIPYVTSDNYRGAVMATNLLIEKGCRFLAHISGPLQLNTPANDRYYGFMHVVSQRSVKHVVVETRLNKFDINEYKDIVSQLFKKYPEIDGVFASSDLIAAVVIRVAEDFGKKVPESLKVVGFDDVNIASIMKPSITTVRQYKDKMAQKAIDLIINKIEGNNVEVSNVIPIDLIEREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZF4</accession>
    <name>B8DZF4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0599</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582972.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352501.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0599"/>
    <dbReference type="EnsemblBacteria" id="ACK41887">
        <property type="protein sequence ID" value="ACK41887"/>
        <property type="gene ID" value="Dtur_0599"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0599"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516570_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZF4"/>
    <dbReference type="OMA" id="DRREFNY"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="114"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="196"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="385"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="470"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="580" mass="64485" checksum="A167A83337585E9F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZH9</accession>
    <name>B8DZH9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, TM1802 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582997.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352526.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0624"/>
    <dbReference type="EnsemblBacteria" id="ACK41912">
        <property type="protein sequence ID" value="ACK41912"/>
        <property type="gene ID" value="Dtur_0624"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0624"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.661"/>
    <dbReference type="eggNOG" id="ENOG502Z952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475498_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZH9"/>
    <dbReference type="OMA" id="FYTIDKP"/>
    <dbReference type="OrthoDB" id="709504at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013389">
        <property type="entry name" value="CRISPR-assoc_prot_Cas8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013420">
        <property type="entry name" value="CRISPR-assoc_prot_Csh1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09484">
        <property type="entry name" value="Cas_TM1802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02591">
        <property type="entry name" value="cas_Csh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02556">
        <property type="entry name" value="cas_TM1802"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="585" mass="68805" checksum="292C6AAFE576E2AB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZJ2</accession>
    <name>B8DZJ2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583010.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352539.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0640"/>
    <dbReference type="EnsemblBacteria" id="ACK41925">
        <property type="protein sequence ID" value="ACK41925"/>
        <property type="gene ID" value="Dtur_0640"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0640"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_7_0"/>
    <dbReference type="InParanoid" id="B8DZJ2"/>
    <dbReference type="OMA" id="SDNAIMA"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="145" mass="17529" checksum="C34D74474F990787" modified="2009-03-03" version="1">MEKKNIYEIFKEVIREHFIRREKLLSGLKLYRGQAPILLLLSERDGLTQKEIVENMKIKPSTVAIMIRRMKKRGLVITKRDEKDKRFSKVYLTDEGRKFICKLKKTYKQLEEECFGNFTEEERETLKNYLERIRDNLRILNEEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZQ8</accession>
    <name>B8DZQ8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583076.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352605.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0706"/>
    <dbReference type="EnsemblBacteria" id="ACK41991">
        <property type="protein sequence ID" value="ACK41991"/>
        <property type="gene ID" value="Dtur_0706"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0706"/>
    <dbReference type="eggNOG" id="ENOG502ZJXY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651708_0_0_0"/>
    <dbReference type="OMA" id="MEHKIED"/>
    <dbReference type="OrthoDB" id="2110626at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="416" mass="49529" checksum="91AB5C7CBEF3A1B9" modified="2009-03-03" version="1">MWLLYLDLITRISFIFSLIMAAVIIMYNPVVPFYFFPLLIFLSFMAHILKNFLSEKLRFFVLIPYISIIFLPLGTYEKILILLISLISTYLLLTQKSVSYGLAVDHYRKTSPIAIIIFIISFFMRYLSTSRFTNFELTVLPSLLVYFVVSVFLLRTLRYMEHKIEDKKLVSLNLRYAFGVISLSALLSIPGVRDKIFFITSNIFSIVYFLFTTIIAVIFIVIGYILSWIFYLVLNFMAKRGLIGSLNTRDFRMDPNLSRLLRLLWDRRESHSEIIDILLVISFYILVTGLIILIILWVIRRVFSSQTKGENYIEEREFLFSQINPWNAIRRFLEGRNLGIVREYYRKYLMRSKNLGVDLKPSDTTQDVYKKTFQLFDSEVLRRIREIYIYVRYNRMESSRDLDKEFISLYRRLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZR5</accession>
    <name>B8DZR5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583083.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352612.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0713"/>
    <dbReference type="EnsemblBacteria" id="ACK41998">
        <property type="protein sequence ID" value="ACK41998"/>
        <property type="gene ID" value="Dtur_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0713"/>
    <dbReference type="eggNOG" id="ENOG502ZYMB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130859_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZR5"/>
    <dbReference type="OMA" id="VIIRNQP"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025480">
        <property type="entry name" value="DUF4330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14221">
        <property type="entry name" value="DUF4330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="158" mass="17939" checksum="2A844500FE2623A0" modified="2009-03-03" version="1">MRLKINVFDVVVFLVILLGILGFFLVREGKTPLARVQGVEKEIEIDMIVRNLPLNDKEVIKPGDKAFIRIKNQPFAWVTVKDVKIYEKKMLIPNFNGTYTFIEDVNNPFNVDMLITFTSKGYITEDGVVLGVKVKVGMPISIESYKLDVNGVISALRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZR7</accession>
    <name>B8DZR7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.70" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583085.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352614.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0715"/>
    <dbReference type="EnsemblBacteria" id="ACK42000">
        <property type="protein sequence ID" value="ACK42000"/>
        <property type="gene ID" value="Dtur_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0715"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.752"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034585_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZR7"/>
    <dbReference type="OMA" id="KGTDYTP"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="6">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="164" mass="18643" checksum="C9B4B406BC9153ED" modified="2009-03-03" version="1">MWSSERKIKTKEEICNIAERFREEGKTIVFTNGCFEILHPGHITLLEKAKSFGDILIVGINSDESVKKIKGEKKLIFDEKSRLKIISALECVDYTVLFNEETPENIISIIKPHIHVKGGDYKEEDLPEAKIVKSYGGKIIIVPLIEGFSTTQIINKILALYKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZW3</accession>
    <name>B8DZW3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583131.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352660.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0764"/>
    <dbReference type="EnsemblBacteria" id="ACK42046">
        <property type="protein sequence ID" value="ACK42046"/>
        <property type="gene ID" value="Dtur_0764"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0764"/>
    <dbReference type="HOGENOM" id="CLU_2105100_0_0_0"/>
    <dbReference type="OrthoDB" id="2197938at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="115" mass="13656" checksum="A44D21BEFC2D29CC" modified="2009-03-03" version="1">MFEWLIILYILFVIVSAILNTAKEVKNKREIIIKKAEIPKEEEIKKEVPKEILLPKKTVEKKEKIEEKVKKEKKIEETYIEKSLKNNLPEIIALIEIIGPPKAYQNWTVPYRKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZX5</accession>
    <name>B8DZX5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0776</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583143.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352672.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0776"/>
    <dbReference type="EnsemblBacteria" id="ACK42058">
        <property type="protein sequence ID" value="ACK42058"/>
        <property type="gene ID" value="Dtur_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0776"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.813"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZX5"/>
    <dbReference type="OMA" id="LYRKSTF"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="106"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="218"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="437" mass="49734" checksum="7A7E60A1A0D8E25E" modified="2009-03-03" version="1">MNVGYLFGFIESLKKQKIDCEVFFQEKEKSTLIISRQEVENYQTSKEYGIGVRVIKEGKHGFAYTTNLEELNEIIQKAIEVSQIMEEDRNWQFSKELILKDTKCYPEEPSLQEKISRLLELEREIYSKDKRIKTVRNVVWEKTHENNKILSTTGLFLEYNQQYQYVYTEVGASDGINERSGFDFDVARSWQELELDKLVDKVVWQATSLLGASPKRTQSVDIILPMERAGEFLELISELFSADNVQKGKSILKGFLGERVASSVLNIIEDPFCGEALVPRAFDDEGMKTCRKYFVRNGILENYAYNIYTANKEGKISTGNGVRGSFKALPQVGYFNLYIEPGEKSERELIESVRNGVYVISLMGLHLADTISGDFSLGIEGLWIRNGEFLDPVAEMTISGNLKDFLKNISGIGNKLNFKGNINSPMLKLEDIILAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E000</accession>
    <name>B8E000_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name evidence="2" type="ordered locus">Dtur_0802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583167.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352697.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0802"/>
    <dbReference type="EnsemblBacteria" id="ACK42083">
        <property type="protein sequence ID" value="ACK42083"/>
        <property type="gene ID" value="Dtur_0802"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0802"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.840"/>
    <dbReference type="eggNOG" id="COG1351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077585_0_0_0"/>
    <dbReference type="InParanoid" id="B8E000"/>
    <dbReference type="OMA" id="AKLGPRC"/>
    <dbReference type="OrthoDB" id="896350at2"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="156"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="218" mass="25519" checksum="354081C9E5F346E1" modified="2009-03-03" version="1">MKVKLISYTPEPEKVCALAMRLCHYQGSIEELEEKLTPEEIVRLLNKAKKLQHMSIFEHASFTFYIEGVSRVTTHQLVRHRIASYSQQSQRYVKIKDEYVIPETIKKEEQRLNVYRDLIERAFDAYEELVKLGVPKEDARYLLPQAIESKIIVTMNARELMHFFTLRTCNSAQWEIRELAWKMLELVRNVAPTIFSDAGPPCFRGPCPEGKTCVPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E019</accession>
    <name>B8E019_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="8">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="8">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabZ</name>
        <name evidence="9" type="ordered locus">Dtur_0821</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583186.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352716.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0821"/>
    <dbReference type="EnsemblBacteria" id="ACK42102">
        <property type="protein sequence ID" value="ACK42102"/>
        <property type="gene ID" value="Dtur_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0821"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.860"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_1_0_0"/>
    <dbReference type="InParanoid" id="B8E019"/>
    <dbReference type="OMA" id="FPGRPLM"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="3 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="8">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="144" mass="16336" checksum="3568D8F89B1E92B0" modified="2009-03-03" version="1">MREIDILSILPHRFPFLFVDKVIEYKEGESLKAVKNVSYNDYFFIGHFPQRPVMPGVLMVEALAQASGLLLYLTYGEGKDPNSFMAYLAGINNFKFRRNVFPGDVLILEVKIKQTLRNIYKLDTKAFVDDKLVAEGEITIALGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E029</accession>
    <name>DUT_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="1">dUTPase</shortName>
            <ecNumber evidence="1">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dut</name>
        <name type="ordered locus">Dtur_0831</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583196.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352726.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E029"/>
    <dbReference type="SMR" id="B8E029"/>
    <dbReference type="STRING" id="515635.Dtur_0831"/>
    <dbReference type="EnsemblBacteria" id="ACK42112">
        <property type="protein sequence ID" value="ACK42112"/>
        <property type="gene ID" value="Dtur_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0831"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.870"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_1_3_0"/>
    <dbReference type="InParanoid" id="B8E029"/>
    <dbReference type="OMA" id="YAAFVHP"/>
    <dbReference type="OrthoDB" id="1669228at2"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000119233" description="Deoxyuridine 5'-triphosphate nucleotidohydrolase">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="84"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <sequence length="147" mass="16102" checksum="1DEECB48958038F9" modified="2009-03-03" version="1">MIRVLIERIDKDLPLPNYATHGSAALDLYSRIDFELPPFGEIGGGLVIPTGIRIALPEGYLALVLPRSGLAAREGISVLNTPGLIDSDYRGEIFVNLINFSNKPFLGKRGMRIAQLLVLQYSRIIWEEVEQLPQTERGEGGLGSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8E031</accession>
    <name>B8E031_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583198.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352728.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0833"/>
    <dbReference type="EnsemblBacteria" id="ACK42114">
        <property type="protein sequence ID" value="ACK42114"/>
        <property type="gene ID" value="Dtur_0833"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0833"/>
    <dbReference type="eggNOG" id="COG4481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180138_0_0_0"/>
    <dbReference type="InParanoid" id="B8E031"/>
    <dbReference type="OMA" id="HQAWIPR"/>
    <dbReference type="OrthoDB" id="2041238at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009296">
        <property type="entry name" value="DUF951"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38455">
        <property type="entry name" value="PTHR38455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06107">
        <property type="entry name" value="DUF951"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="70" mass="8075" checksum="CA33820DA1A7B8B3" modified="2009-03-03" version="1">MIDKIQVGDILELPKKHPCGGNRWIVLFSGVDIKLKCEKCGRIVMLPRIEVRRKAKKVGEVNLEELLKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E061</accession>
    <name>B8E061_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-layer domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583228.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352758.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0863"/>
    <dbReference type="EnsemblBacteria" id="ACK42144">
        <property type="protein sequence ID" value="ACK42144"/>
        <property type="gene ID" value="Dtur_0863"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0863"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_443935_0_0_0"/>
    <dbReference type="InParanoid" id="B8E061"/>
    <dbReference type="OMA" id="GTFQGNQ"/>
    <dbReference type="OrthoDB" id="554219at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00176">
        <property type="entry name" value="SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001119">
        <property type="entry name" value="SLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018159">
        <property type="entry name" value="Spectrin/alpha-actinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00395">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51272">
        <property type="entry name" value="SLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLH" evidence="3">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="380"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="90"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="694" mass="75072" checksum="BBB30598FBA1F6E8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E064</accession>
    <name>B8E064_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1-phosphofructokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583231.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352761.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0866"/>
    <dbReference type="EnsemblBacteria" id="ACK42147">
        <property type="protein sequence ID" value="ACK42147"/>
        <property type="gene ID" value="Dtur_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0866"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.904"/>
    <dbReference type="eggNOG" id="COG1105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050013_0_2_0"/>
    <dbReference type="InParanoid" id="B8E064"/>
    <dbReference type="OMA" id="QLNEPGP"/>
    <dbReference type="OrthoDB" id="1323781at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008662">
        <property type="term" value="F:1-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008443">
        <property type="term" value="F:phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01164">
        <property type="entry name" value="FruK_PfkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017583">
        <property type="entry name" value="Tagatose/fructose_Pkinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000535">
        <property type="entry name" value="1PFK/6PFK/LacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03168">
        <property type="entry name" value="1-PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="5">
        <location>
            <begin position="11"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="310" mass="35162" checksum="D6034BB2279DAD6D" modified="2009-03-03" version="1">MILIVNINPSLDVIFYTKGFHKSKVNRSYKEEIVPGGKGINVAKTLKAFGEEVKVIGFCGGSTGIILKEELKKRNIDYELVEIKGKTRFAIGIKEDKKKEFTVLNGSGDKINEEEWNSFFKIFKENLENAKIVIISGSIPPETPTEIYALMLKEIKNPKILRVLDARDNVLKEALKESPDIVKPNKEEMENLLSKKLKNKNDYIYAIRYLRSFNIKYPLISLSKKGALIGIEEGIYKATLPPNDGIQWGTGDSFLAGFIFGLKNYQDPFEAIKLACASGYVKTKYPEIIDKQQIKEIFILKDKVKVKRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>B8E083</accession>
    <name>B8E083_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrA</name>
        <name evidence="16" type="ordered locus">Dtur_0885</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583250.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352780.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0885"/>
    <dbReference type="EnsemblBacteria" id="ACK42166">
        <property type="protein sequence ID" value="ACK42166"/>
        <property type="gene ID" value="Dtur_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0885"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.923"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_0"/>
    <dbReference type="InParanoid" id="B8E083"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="248"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="600"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="736"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="637"/>
            <end position="644"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACK42166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="947" mass="106199" checksum="C8EB083050859BDD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0A3</accession>
    <name>B8E0A3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583630.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353162.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1270"/>
    <dbReference type="EnsemblBacteria" id="ACK42548">
        <property type="protein sequence ID" value="ACK42548"/>
        <property type="gene ID" value="Dtur_1270"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1270"/>
    <dbReference type="eggNOG" id="COG2129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095253_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0A3"/>
    <dbReference type="OMA" id="DPCHRGF"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="194" mass="22127" checksum="29508DC695C86F02" modified="2009-03-03" version="1">MKILALADIESPNFYERFDISPYRGVEGVISCGDVMPELLTYIATMLNVPVFYVYGNHDEIYLKRPPEGCENIDGRIIEFKGKKILGLGGSIKYSDGKFQFTEKEMEGRIRRLYFKLRKGIDIVVAHSPPAGVHETGDFAHKGFESFLKLIIKYQPKYFLHGHTHMNYVYNSQRIAEIGKTKVINCSGIVILEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0A4</accession>
    <name>B8E0A4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional phosphoglucose/phosphomannose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583631.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353163.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1271"/>
    <dbReference type="EnsemblBacteria" id="ACK42549">
        <property type="protein sequence ID" value="ACK42549"/>
        <property type="gene ID" value="Dtur_1271"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1271"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1311"/>
    <dbReference type="eggNOG" id="COG2222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059687_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0A4"/>
    <dbReference type="OMA" id="FPELNHN"/>
    <dbReference type="OrthoDB" id="1179564at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05017">
        <property type="entry name" value="SIS_PGI_PMI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05637">
        <property type="entry name" value="SIS_PGI_PMI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035484">
        <property type="entry name" value="SIS_PGI/PMI_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="41"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="356" mass="40300" checksum="F89F17EBAA12EE63" modified="2009-03-03" version="1">MVEKLDQIEELKKLDPKDMYSAVYNLPEQIERAAEVAYNAEIKNISDKIDKVLVLGMGGSAIGGDVLQSVLFKEAKFPVFVNRDYDLPNWVDESTLVFAVSYSGHTVETINSAKLSYSRGASVVAVTSGGVLKEFAQENNLTLVEIPSGMAPRAAIGYVTIPSFVILERLGLISSKKKDIEETVAYLRNKREEFKIEVPTEQNVAKKVAKMMFKHIPVIYAVEEKWKVAAYRWKCQINENSKYPAFYHFFPELNHNEIMAWEAIDNVIKPLTLIFLYTSLEGEMKIRVEFMQEKISARGVPVFLWQAEGNNPLTQFFSLTYLGDFATVYLAYLADKDPFSIGYINELKLRIGQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0C2</accession>
    <name>B8E0C2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583649.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353181.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1289"/>
    <dbReference type="EnsemblBacteria" id="ACK42567">
        <property type="protein sequence ID" value="ACK42567"/>
        <property type="gene ID" value="Dtur_1289"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1289"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1332"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555216_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0C2"/>
    <dbReference type="OMA" id="GNKQWTR"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02608">
        <property type="entry name" value="delta_60_rpt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867739" evidence="1">
        <location>
            <begin position="25"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="403" mass="44050" checksum="8DC66BE89B469521" modified="2009-03-03" version="1">MKKIFLLLSVFLIFSLLISGCAPKKDTTPPQQVWQKTYGGSNDDEAFSIQQTTDGGYIVAGWTESFGAGNRDVYIIKLDSNGNKVWEKTYGGEYYDRASSIQQTSDGGYIVAGGTYSFGAGYYDFYIIKLDSNGNKVWEKTYGRSDWDNGAYSIQQTTDGGYIVAGYTWSFGAGGDFYIIKLDSNGNKVWEKTYGGSNWDDWASSIQQTTDGGYIVAGLTYSFGAGSADFYIIKLDSNGDKVWEKTYGGSKNDVAFSIQQTTDGGYIVAGLTDSFGAGYDDFYIIKLDSNGDKVWEKTYGGSSYDEAYSIQQTTDGGYIVAGLTDSFGAGGSNFYIIKLDSNGDKVWEKTYGGSNDDWARSIQQTTDGGYIVAGWTRSFGAGNRDFYIIKTDSEGNTGPYPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0C9</accession>
    <name>B8E0C9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353188.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42574">
        <property type="protein sequence ID" value="ACK42574"/>
        <property type="gene ID" value="Dtur_1300"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1300"/>
    <dbReference type="HOGENOM" id="CLU_1406797_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="193" mass="22460" checksum="85F6782D0CE0DAAB" modified="2009-03-03" version="1">MIYRTKGGNKMKRVTKKFLCISLIAMLILGFSIPIYAQMGPKEIRKDLREREREREFRKLVIPGERYKGDYDIFVVYVEPKGIIISIDLGYSNYEGITEEGLNSFFSSIWRVFGYGISKYPPTIKVNFYIELGDEDSLIVEFPIGALLDFFKEKITRAEFLKQCEIWINGEKAVIEGDVIKVLGKEFKMDFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0L3</accession>
    <name>B8E0L3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNP-1 like RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584108.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353647.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1761"/>
    <dbReference type="EnsemblBacteria" id="ACK43033">
        <property type="protein sequence ID" value="ACK43033"/>
        <property type="gene ID" value="Dtur_1761"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1761"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_8_0"/>
    <dbReference type="InParanoid" id="B8E0L3"/>
    <dbReference type="OMA" id="PYSFRDQ"/>
    <dbReference type="OrthoDB" id="2029304at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="96" mass="10977" checksum="9BB69F528647EA41" modified="2009-03-03" version="1">MVKTLYVGNLSWQTTEEDIKGLFGGEGEIQSVRLITDRNTGRSKGFAFVETTEEVAQKLIDSYNGYEFNGRKIVVSEARPKEERRSSSSRSHNRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0R1</accession>
    <name>B8E0R1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584155.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353695.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1810"/>
    <dbReference type="EnsemblBacteria" id="ACK43081">
        <property type="protein sequence ID" value="ACK43081"/>
        <property type="gene ID" value="Dtur_1810"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1810"/>
    <dbReference type="eggNOG" id="ENOG503374C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173848_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0R1"/>
    <dbReference type="OMA" id="DRCFRLM"/>
    <dbReference type="OrthoDB" id="1875376at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK43081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="99" mass="11412" checksum="6E15B6DF42CDA329" modified="2009-03-03" version="1">MFSWLKKLFSSSPSQISSSSFIVSVKCKRCGEIIDVRVRPKEEANPEFGDMDQIIKYELFKDVLGTKCPNLMRLHIEFSPSWSIISKEIENGEIIEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0S3</accession>
    <name>B8E0S3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2062 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583738.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353274.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1386"/>
    <dbReference type="EnsemblBacteria" id="ACK42660">
        <property type="protein sequence ID" value="ACK42660"/>
        <property type="gene ID" value="Dtur_1386"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1386"/>
    <dbReference type="eggNOG" id="COG3216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102912_1_2_0"/>
    <dbReference type="InParanoid" id="B8E0S3"/>
    <dbReference type="OMA" id="GCFPFFG"/>
    <dbReference type="OrthoDB" id="1672574at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="2">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="151" mass="17348" checksum="30CE7B6EEAD0EEC4" modified="2009-03-03" version="1">MKKRRNLKSLLRYIYLKLLRFKDPPEKIALSFSIGVFIGIFPTFGVGGILVILISYIFKLNYLAGLLGTFIMNYFTSPFFWALSYFVGDFILTGKFEWRGFERGSFKVFAISYLLGNFIVSTTFSVISYLVVKKIVTTYRKKRGGHKPSSS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0U2</accession>
    <name>NTPPA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="1">dTTPase/UTPase</shortName>
            <ecNumber evidence="1">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="1">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_1405</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583757.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353293.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0U2"/>
    <dbReference type="SMR" id="B8E0U2"/>
    <dbReference type="STRING" id="515635.Dtur_1405"/>
    <dbReference type="EnsemblBacteria" id="ACK42679">
        <property type="protein sequence ID" value="ACK42679"/>
        <property type="gene ID" value="Dtur_1405"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1405"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1452"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0U2"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000211768" description="dTTP/UTP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <sequence length="193" mass="21742" checksum="98942B84A1575D18" modified="2009-03-03" version="1">MRKEIILASNSPRRIYLLGQIGIDFKVVSPNVEEEGNSERRSPVDIVKSNALKKVQKVAEEYRNAIIIGADTVVVLDGEIIGKPKDERDAIRILKRLRDRYHFVFSGVAVMETPEEKVLTSVVRSKVKMRDYSDEEIERYVATGEPMDKAGAYGIQGKGALLVEKIEGDYYNIVGLPLVRLNSLLNRFGYSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0V8</accession>
    <name>B8E0V8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="2" type="ordered locus">Dtur_1421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583773.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353309.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1421"/>
    <dbReference type="EnsemblBacteria" id="ACK42695">
        <property type="protein sequence ID" value="ACK42695"/>
        <property type="gene ID" value="Dtur_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1421"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1468"/>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_3_1_0"/>
    <dbReference type="InParanoid" id="B8E0V8"/>
    <dbReference type="OMA" id="LHFVCRD"/>
    <dbReference type="OrthoDB" id="1527083at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="217" mass="24241" checksum="47AD1258F608DA34" modified="2009-03-03" version="1">MRVGVVVFPGTNCDMDTYHALRLVGHDPVYLWHKEHDLKNVDVVILPGGFSYGDYLRAGAIARFSPIMNEIIDFAKKGGYVLGICNGFQILLEAGLLPGAMLPNITNSFICKEVFLEVINNNTLFLKNYKVGEILKMPIAHKEGRYYISKRELEELKENNQIVLKYYGENPNGSLENIAGIINKKGNVMGLMPHPERAVEEILGSTSGLNLFLTLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E102</accession>
    <name>B8E102_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583817.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353353.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1465"/>
    <dbReference type="EnsemblBacteria" id="ACK42739">
        <property type="protein sequence ID" value="ACK42739"/>
        <property type="gene ID" value="Dtur_1465"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1465"/>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047530_1_3_0"/>
    <dbReference type="InParanoid" id="B8E102"/>
    <dbReference type="OMA" id="PSYVHCY"/>
    <dbReference type="OrthoDB" id="2071222at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="234" mass="27379" checksum="73E22603129CC0E1" modified="2009-03-03" version="1">MVEESKTLGEILREEREKRGLSLREVSDSLKISYRYLKALEDDEYDKVNLAEIYKKGILKKYVKFLGLFEDEIFKIYTAQYKTKIEESLPKLAKSERCSWKYGVYLIVIFIIFLTLFLTAKFNQRETPKNVRTDIRNYELTMTETYTESNSEVNFTHTFTDTIKVVAVDRVWLRVSYNNNTIYEGTLKEGDTLTWTYTPLYFHIGNAGGLEIYYNDNSLGVLGKKGEVIKIKVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E103</accession>
    <name>B8E103_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583818.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353354.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1466"/>
    <dbReference type="EnsemblBacteria" id="ACK42740">
        <property type="protein sequence ID" value="ACK42740"/>
        <property type="gene ID" value="Dtur_1466"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1466"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1515"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_0"/>
    <dbReference type="InParanoid" id="B8E103"/>
    <dbReference type="OMA" id="HVPKTYE"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="241" mass="28117" checksum="B4BC8E8AFA86E5A3" modified="2009-03-03" version="1">MMERLQKFISRSGVTSRRKAEELILEGRVKVNGKVIRTLGVKIDPEKDVVEVDNKIIKPEKKLYIALYKPVGYLSSLYDPFGRRTIKDLLKDKLSSRVYPVGRLDFDSEGLLLCTNDGEIANFVIHPRYKIPKIYEVLVNGIPKEEELKKFREGVILEEGKTLPAEFEVVWKNSKTKRSLLKVVLYQGWKRQIRRMLALFGYEVLKLKRIQIGEIRLGNLKPGEFRFLNDEEIKWLKSLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E104</accession>
    <name>B8E104_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chromosome segregation and condensation protein, ScpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583819.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353355.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1467"/>
    <dbReference type="EnsemblBacteria" id="ACK42741">
        <property type="protein sequence ID" value="ACK42741"/>
        <property type="gene ID" value="Dtur_1467"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1467"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_3_0"/>
    <dbReference type="InParanoid" id="B8E104"/>
    <dbReference type="OMA" id="FYTKPEY"/>
    <dbReference type="OrthoDB" id="1771906at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="165" mass="19351" checksum="CE663DF1D7751147" modified="2009-03-03" version="1">MKEIKPIIKKQIEALIFVADKPLYPQEIAKILEITVEEVEYILQELKKEYEERGINLYKINGAYEFATSPDTASALWRYVSRKRERLSKAALEALAIIYYHQPITKAEIETIRGAKVDSVLGMLLEKRLVKIVGRKETIGRPFLYGIGDEFYRYFFIEDDEELRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E109</accession>
    <name>DEOB_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopentomutase</fullName>
            <ecNumber evidence="1">5.4.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphodeoxyribomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoB</name>
        <name type="ordered locus">Dtur_1472</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphotransfer between the C1 and C5 carbon atoms of pentose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-ribose 1-phosphate = D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:18793"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27658"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="5.4.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 or 2 manganese ions.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route II): step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphopentomutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583824.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353360.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E109"/>
    <dbReference type="SMR" id="B8E109"/>
    <dbReference type="STRING" id="515635.Dtur_1472"/>
    <dbReference type="EnsemblBacteria" id="ACK42746">
        <property type="protein sequence ID" value="ACK42746"/>
        <property type="gene ID" value="Dtur_1472"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1472"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1521"/>
    <dbReference type="eggNOG" id="COG1015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053861_0_0_0"/>
    <dbReference type="InParanoid" id="B8E109"/>
    <dbReference type="OMA" id="YLGNCHA"/>
    <dbReference type="OrthoDB" id="1772797at2"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00173"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043094">
        <property type="term" value="P:cellular metabolic compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16009">
        <property type="entry name" value="PPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00740">
        <property type="entry name" value="Phosphopentomut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010045">
        <property type="entry name" value="DeoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024052">
        <property type="entry name" value="Phosphopentomutase_DeoB_cap_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21110">
        <property type="entry name" value="PTHR21110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001491">
        <property type="entry name" value="Ppentomutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143856">
        <property type="entry name" value="SSF143856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01696">
        <property type="entry name" value="deoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000133067" description="Phosphopentomutase">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00740"/>
        </source>
    </evidence>
    <sequence length="394" mass="43758" checksum="EC5FBF81D053C9D9" modified="2009-03-03" version="1">MKRAILIVLDGVGIGELPDAFKYNDEGSNTLVNTAKVVGGLNLPNMGKMGLSNIEEIPGIPKEEDPIALYGKMAEASPGKDSTTGHWEIAGLILEKPFPVYPNGFPKEIIEAFEKAIGRKVIGNKPASGTEIIKELGEYHMKTGYPIVYTSADSVFQIAAHEDVIPVEELYRMCEIARAMLQGDHAVARVIARPFAGSPGNFYRTPRRRDFSLPPFKPTLLDYLKQNDYDVIGVGKIEDLFAGKGLTSSFHQENNTEGINNIFKAWEKLREGLIFVNLVDFDMLYGHRNDPQGMTRALKEFDDALPDVMGLLSDFDLLIITADHGNDPTTPSTDHSREYVPLLVYSPNFKRTFSLGIRKTFSDLGKTLAEFFEVENDLCGESFLNEIEKGWKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E119</accession>
    <name>B8E119_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UvrB/UvrC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583834.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353370.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1482"/>
    <dbReference type="EnsemblBacteria" id="ACK42756">
        <property type="protein sequence ID" value="ACK42756"/>
        <property type="gene ID" value="Dtur_1482"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1482"/>
    <dbReference type="eggNOG" id="COG3880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102553_1_0_0"/>
    <dbReference type="InParanoid" id="B8E119"/>
    <dbReference type="OMA" id="CGKRPAT"/>
    <dbReference type="OrthoDB" id="1370308at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046870">
        <property type="term" value="F:cadmium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990170">
        <property type="term" value="P:stress response to cadmium ion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990169">
        <property type="term" value="P:stress response to copper ion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025542">
        <property type="entry name" value="YacH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38430">
        <property type="entry name" value="PTHR38430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015034">
        <property type="entry name" value="YacH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="145" mass="17138" checksum="246B7BAB060C1163" modified="2009-03-03" version="1">MKCDFCNQNEAVYVLEISDEKGKRKYSICEYCLKQVIKDIFQGNYFMRDEKVKRCPKCNRSLEEIKETGMLGCSYCYSYFRDEIGKLVYQYHGNKVHRGRVPIKKEFKTDKILKYKIELSKAIEEEDYEKAAKLRDLLKNIGKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E149</accession>
    <name>B8E149_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="5">2.4.1.25</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583261.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352791.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0896"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42177">
        <property type="protein sequence ID" value="ACK42177"/>
        <property type="gene ID" value="Dtur_0896"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0896"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.934"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026700_0_0_0"/>
    <dbReference type="InParanoid" id="B8E149"/>
    <dbReference type="OMA" id="HFMSAGL"/>
    <dbReference type="OrthoDB" id="94039at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015179">
        <property type="entry name" value="A-amylase/a-glucTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015178">
        <property type="entry name" value="A-amylase/a-glucTrfase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09094">
        <property type="entry name" value="DUF1925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09095">
        <property type="entry name" value="DUF1926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="2">
        <location>
            <begin position="26"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1925" evidence="3">
        <location>
            <begin position="314"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1926" evidence="4">
        <location>
            <begin position="404"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="686" mass="81611" checksum="C7E8C9F86DAB0BDD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E193</accession>
    <name>B8E193_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="5" type="ordered locus">Dtur_0940</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583305.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352835.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0940"/>
    <dbReference type="EnsemblBacteria" id="ACK42221">
        <property type="protein sequence ID" value="ACK42221"/>
        <property type="gene ID" value="Dtur_0940"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0940"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_3_0"/>
    <dbReference type="InParanoid" id="B8E193"/>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="63" mass="7457" checksum="A74153BA40672DED" modified="2009-03-03" version="1">MGLPKKKLSTTRRDRRWVRYKLSGVALVECPHCHKKIRPHRVCPFCGYYEGREVIAVKSEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E198</accession>
    <name>B8E198_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Dtur_0945</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583310.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352840.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0945"/>
    <dbReference type="EnsemblBacteria" id="ACK42226">
        <property type="protein sequence ID" value="ACK42226"/>
        <property type="gene ID" value="Dtur_0945"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0945"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.982"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_0"/>
    <dbReference type="InParanoid" id="B8E198"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="5"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="413" mass="44754" checksum="2C9B51DF148677C9" modified="2009-03-03" version="1">MRRRVAITGLGVISPVGIGKDVFWENIKKGESGISFISKFPTDDFPTKIAGEVKDFNPEEFIDKREARRLDRFSQFAIAATRLALEDSGWNPTEEEKENTAVIVTSGIGGFETLENQFRSLFEKGPNRISPFLIPMVIINIASGNISIFFGFKGPNYSPVSACASSAHAIGIGYRLVSTGEADFAIVGGSEASITPMGIAGFCALQALSTRNDEPEKASRPFDAKRDGFVMGEGAGILILEELNHAINRGARIYAEIVGFGASDDAYHITAPDPEGNGAVLSMKRAIKDAGINPEDINYINAHGTSTKLNDKIETLAIKKVFGEYAYKIPVSSTKSMVGHLLGAAASVESIATVLSIYEGIIHPTINYEEKDPECDLDYVPNVARKWDIKYALKNSFGFGGQNATLIFKKYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1A5</accession>
    <name>B8E1A5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">D-alanine--D-alanine ligase</fullName>
            <ecNumber evidence="7">6.3.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">D-Ala-D-Ala ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">D-alanylalanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ddl</name>
        <name evidence="11" type="ordered locus">Dtur_0952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583317.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352847.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0952"/>
    <dbReference type="EnsemblBacteria" id="ACK42233">
        <property type="protein sequence ID" value="ACK42233"/>
        <property type="gene ID" value="Dtur_0952"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0952"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.989"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039268_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1A5"/>
    <dbReference type="OMA" id="NTTPGMT"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039102">
        <property type="entry name" value="Ddl/VanB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="99"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR039102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="311" mass="34713" checksum="F038F6356F9361B4" modified="2009-03-03" version="1">MRVGVLIGVKSSEKEIALKTARNIINALKLKGYDYIEIPIDENVVENIKKSKIDVAIISAHGKYGEDGTIQGLLELLGIPYVGSGVLASALALDKMMAKKIFTFHQIPTPKWKELSKKEIETRDLNEILKDLSYLKKPWIIKPATQGSTIGLSLVNQEEELLKGIELAFQYDENIIVEEYIKGIEITAGIYDVNKPICLPLIEIIPKTGFYDYKTKYTPGLSDHIIPARLPKEVYEKAQGLGILAHQALGCRHLSRVDMIVEENTNNIYVLEVNTIPGMTETSLYPEAAKAFGIEFPDLIDNFIKATLKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1C6</accession>
    <name>B8E1C6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="15" type="ordered locus">Dtur_0974</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583338.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352868.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0974"/>
    <dbReference type="EnsemblBacteria" id="ACK42254">
        <property type="protein sequence ID" value="ACK42254"/>
        <property type="gene ID" value="Dtur_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0974"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1011"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_3_0"/>
    <dbReference type="InParanoid" id="B8E1C6"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="12">
        <location>
            <begin position="25"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="11">
        <location>
            <begin position="158"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="13">
        <location>
            <begin position="384"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="14">
        <location>
            <begin position="462"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="9">
        <location>
            <begin position="589"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="10">
        <location>
            <begin position="981"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACK42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1070" mass="120351" checksum="EE1C51EB90E23287" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1F7</accession>
    <name>RS13_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsM</name>
        <name type="ordered locus">Dtur_1005</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583368.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352899.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1F7"/>
    <dbReference type="SMR" id="B8E1F7"/>
    <dbReference type="STRING" id="515635.Dtur_1005"/>
    <dbReference type="PRIDE" id="B8E1F7"/>
    <dbReference type="EnsemblBacteria" id="ACK42285">
        <property type="protein sequence ID" value="ACK42285"/>
        <property type="gene ID" value="Dtur_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1005"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1042"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1F7"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000141259" description="30S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="124" mass="14142" checksum="ED77D836C8B3A931" modified="2009-03-03" version="1">MARIAGVDLPSNKKVEIALTYIYGIGRTTSKKILQATGVDPNKRVKDLTEEEISKLREEIENNYKVEGDLRQEVAANIRRLIEIGCYRGIRHKRGLPVRGQRTRCNARTRKGPRKTVGAKRKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1I8</accession>
    <name>B8E1I8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352127.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0184"/>
    <dbReference type="EnsemblBacteria" id="ACK41513">
        <property type="protein sequence ID" value="ACK41513"/>
        <property type="gene ID" value="Dtur_0184"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0184"/>
    <dbReference type="HOGENOM" id="CLU_914413_0_0_0"/>
    <dbReference type="OMA" id="QNTTELM"/>
    <dbReference type="OrthoDB" id="29166at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="304" mass="35517" checksum="03BE910F72ADE629" modified="2009-03-03" version="1">MYLLERVKPEFENLPAALLNAERFIKKLRNEKATGVIVYNSDNGRGAIFVFEGKAFFAKVENNKVLERTEAVDFIMRQIQQGYGKITYYPTDMVLILVLSAIYVGTPLYVDLDANTIIPTKFFTALQNREFSGVVLYRSAEDVKFWIFKKGKSTNPPPVILPPYGFISVYALDTIEVKDYLELWEQEARRKIIEFSEKLLSAIARTLVEKWGQNTTELMLLPLESYQGPINIKFDKKTWSCKIESNEELYYLAKEIERLYARLLRAIREREEIVAENVELYTFNLMQEENVLWPPTEENVFRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1L2</accession>
    <name>B8E1L2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0208</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582622.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352151.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0208"/>
    <dbReference type="EnsemblBacteria" id="ACK41537">
        <property type="protein sequence ID" value="ACK41537"/>
        <property type="gene ID" value="Dtur_0208"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0208"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_0"/>
    <dbReference type="InParanoid" id="B8E1L2"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="264" mass="29436" checksum="7DAE441A8F3B8F66" modified="2009-03-03" version="1">MSKIISVANQKGGVGKTTTVINLGYSLAEQGMKILLVDADPQGNTTSGISNLKNQKPNLYSALIEEVSIEKVIYSLGDGKNKVRENLFIIPSNIDLAGAEIELVSMLFRELKLKEILDKIKENFDIILIDSPPSLGLLTVNSLVASDYVLIPLQCEYYALEGISQLLKTINLIRKNLNQNLEILGVLLTMYSRTTLAQQVIEEAQKYFKDKVFKTLIPRNVRLSEAPSYSQSIFEYAPDSSGAEAYREITKEVIQRVFSKEGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1N4</accession>
    <name>B8E1N4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582644.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352173.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0230"/>
    <dbReference type="EnsemblBacteria" id="ACK41559">
        <property type="protein sequence ID" value="ACK41559"/>
        <property type="gene ID" value="Dtur_0230"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0230"/>
    <dbReference type="HOGENOM" id="CLU_541565_0_0_0"/>
    <dbReference type="OMA" id="WGRIKEP"/>
    <dbReference type="OrthoDB" id="2105420at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="503" mass="59291" checksum="222C1325EA2BC97F" modified="2009-03-03" version="1">MKKIILLIFALIFLTSISYSQELIFDISLGIKSEWKLERFLPLFIDIYNPGNRITLNIEAIYNQGLRYAGYCETVYQENIEIPPLSNKKIEFLIPPIDFRYPLRLRIWHNNKLIREEKIDISLERIVLPLILILGKNIPSLPFSEKARILRIYDEKFLPLNYKAYDNFDLILIERAFWDKLPTNLKNSITMYKILTGRVYFTDEVKKIPLELLKIPPVNITIPHNTILYTPDISLLQGQKFLYPDRFIITAALIIYFISLFLWKNFLFKKRFSFITFLTIISIFSILGFQVKNSFEKDALAVGEKSLIYLDPNTFVGENYFNVSLFSPFKRDISFNYSPNIFLLYNAYYQPQKGKVSLFINRKENKGKIILEKNRVYFLEGLSFHFLPINIDFKELPDRFILIIENNSNFELRDLVLKLGNAENYIGSITKGERKDITVWKSGLKEPSLLNEILKNYRLKTSLISKKRILLWGRIKEPLNQFNFDDIKTEVYRDNILIIPLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1P5</accession>
    <name>B8E1P5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582655.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352184.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0244"/>
    <dbReference type="EnsemblBacteria" id="ACK41570">
        <property type="protein sequence ID" value="ACK41570"/>
        <property type="gene ID" value="Dtur_0244"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0244"/>
    <dbReference type="eggNOG" id="ENOG502ZEYY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_609340_0_0_0"/>
    <dbReference type="OrthoDB" id="2043847at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="449" mass="51343" checksum="156358ED8692455D" modified="2009-03-03" version="1">MRKILIKFFIILMFLLIITFASSFKGQDYNGFNFPYKGALFLHDGDFVEFYCDSNHSVFYYLTFKSGNCPVEVMERKNDGSWKSIKTIILPPKMYSNNVNLNNLSFLGFFDLANVPGCLNKRIGIHLRENRTIGGNYYGDKDLFIMLKDGTNVYLWKGVDSYEAFDLDGRARKEDKWIEYANSLVDKRIATINNMINTFIEISSLNETSEAMKSALGNLLNGISSSYFPPDHLSLAKDYCINIATEYLSLYSQWAISMTRSLNYVVCGALGDVYSGAFEGLQYVQWMQNILSKTIPQSILTVNEAYDRTLSFKSFVGRIRTASSSQLDNLKQYLLKEKEARQIKNKENLRNTLISQLSLLHSSSCDNNPLFTNDQDISKGEGLSLWHIYAKACSIAKSRENDPNYPKGERQAYSMLRILTEKLMATILNLYLETLWVKNAEEVSYLLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Q6</accession>
    <name>B8E1Q6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352195.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0255"/>
    <dbReference type="EnsemblBacteria" id="ACK41581">
        <property type="protein sequence ID" value="ACK41581"/>
        <property type="gene ID" value="Dtur_0255"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0255"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351881_0_0_0"/>
    <dbReference type="OMA" id="NINSFPY"/>
    <dbReference type="OrthoDB" id="803820at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="724" mass="84958" checksum="2FEAF790514FBD57" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1R0</accession>
    <name>B8E1R0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recR</name>
        <name evidence="9" type="ordered locus">Dtur_0259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582670.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352199.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0259"/>
    <dbReference type="EnsemblBacteria" id="ACK41585">
        <property type="protein sequence ID" value="ACK41585"/>
        <property type="gene ID" value="Dtur_0259"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0259"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.272"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1R0"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015967">
        <property type="entry name" value="Rcmb_RecR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01300">
        <property type="entry name" value="RECR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="200" mass="22465" checksum="CA456F9EAA6C3843" modified="2009-03-03" version="1">MAEKSIFEKLIDELTKLPGIGPKLAQRIAFYLLKQPQESVEVLANTILKVKKEIKYCSICFNLTEKDPCEICTNPERDKSIICVVAEPKDLWAIEKTSKFHGVYHVLGGLISPLDGVFPEDLRIKELMERVKKGNIKEVILATDSTPEGEATAMYIARLLMEYPVKVTRLAHGLPAGTELDFADEMTLIHALEGRKELIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1R3</accession>
    <name>B8E1R3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582781.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352310.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0392"/>
    <dbReference type="EnsemblBacteria" id="ACK41696">
        <property type="protein sequence ID" value="ACK41696"/>
        <property type="gene ID" value="Dtur_0392"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0392"/>
    <dbReference type="eggNOG" id="COG4902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051317_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1R3"/>
    <dbReference type="OMA" id="YITSAYF"/>
    <dbReference type="OrthoDB" id="1938827at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01048">
        <property type="entry name" value="Ferritin_like_AB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019243">
        <property type="entry name" value="DUF2202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09968">
        <property type="entry name" value="DUF2202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2202" evidence="1">
        <location>
            <begin position="34"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="183" mass="21321" checksum="7187DF65CF026078" modified="2009-03-03" version="1">MKKFLKATLILLFSFILFTNLGISAENLSSQELEDILHMREEEKLARDVYITLYNIHKIPIFYNISNSEQAHMNAVKTLINYYKLKDPVVDDRIGKFTNTKFTELYNTLVERGKKSAVEALKVGIFIEELDIKDLQEAIKRTNKPDIIRVYTNLLKGSQNHMNAFIKVLQRYGETYTPTYTTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1S7</accession>
    <name>B8E1S7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-nitropropane dioxygenase NPD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582795.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352324.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0406"/>
    <dbReference type="EnsemblBacteria" id="ACK41710">
        <property type="protein sequence ID" value="ACK41710"/>
        <property type="gene ID" value="Dtur_0406"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0406"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1S7"/>
    <dbReference type="OMA" id="ATYECDA"/>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="13"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="357" mass="39272" checksum="13DA9771B4AE0FFB" modified="2009-03-03" version="1">MKLPSLKIGDLVASVPIVQGGMAVGISLSGLASAVAEEGGIGVIGTAGIGMEEEDFFENFIEANIRALRKEIRKAKEKTKGIIGVNILVALSNFADMVKTALEEKIDIIFSGAGLPLDLPKYLKKVHKTKLIPIVSSGRAARIIAKNWINKYNYVPDAFVVEGPLAGGHLGFKREELQNPEITLENRLKEVLDEAKIIEEKYNKEIPVIAAGGIYDGKDIAKFLKLGAKGVQMATRFVATYECDADEKFKEAYLKCKKEDIVIIDSPVGLPGRAIKNEFLEAVERGEKKPYKCPFHCIRTCDYQNSPYCIAIALLNAKKGNFKYGFAFAGANAYRVDKIVKVKDLMRELVKEAEENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1V5</accession>
    <name>B8E1V5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582823.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352352.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0436"/>
    <dbReference type="EnsemblBacteria" id="ACK41738">
        <property type="protein sequence ID" value="ACK41738"/>
        <property type="gene ID" value="Dtur_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0436"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035227_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1V5"/>
    <dbReference type="OMA" id="WAIEDSE"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870926" evidence="1">
        <location>
            <begin position="24"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="391" mass="42719" checksum="4A9EEED30DF12216" modified="2009-03-03" version="1">MRRYLKILFLLLFVLFVAGCANFSPKTTWKLIHGYAKNDSVNAGIVSKDGNFIFAGYSNSKNPNGEDDVYVLKIDKWGNVLGELFPFGERDDNAQCIIETSDGGFLVVGESYSYATGISKDLYVMKYDSLGNLSWAKNFGGMDMDGGRWAIEDSEGNYVIVGWTRSFGAGNSDFYVLKLSPNGTVIWTKTWGGGNFDEANSILEVSDGYLVVGFTLSYSAGGKDVALVKFDKNGNVLWYKTYGGSKDDVGSKIIETSDGNFLIIGSTLSYGTSGDIYVLKIDGNGNLLWQANYGGEKEDYANDVKETLDRGFIIVGATRSFSCLGLGIFLVKIDSKGELVWQKVYDGEGDDEANTVILMNDGGFLVGGYTRSWGAEQSDVIIMRLNSKGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1W4</accession>
    <name>B8E1W4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fumarate reductase/succinate dehydrogenase flavoprotein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582832.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352361.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0445"/>
    <dbReference type="EnsemblBacteria" id="ACK41747">
        <property type="protein sequence ID" value="ACK41747"/>
        <property type="gene ID" value="Dtur_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0445"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.470"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_8_1_0"/>
    <dbReference type="InParanoid" id="B8E1W4"/>
    <dbReference type="OMA" id="QHGANRP"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="7"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="473"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="589" mass="66709" checksum="25D8BAA8D4979F19" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1W9</accession>
    <name>B8E1W9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582837.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352366.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0451"/>
    <dbReference type="CAZy" id="CBM4">
        <property type="family name" value="Carbohydrate-Binding Module Family 4"/>
    </dbReference>
    <dbReference type="CAZy" id="GH16">
        <property type="family name" value="Glycoside Hydrolase Family 16"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41752">
        <property type="protein sequence ID" value="ACK41752"/>
        <property type="gene ID" value="Dtur_0451"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0451"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.476"/>
    <dbReference type="eggNOG" id="COG2273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_434595_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1W9"/>
    <dbReference type="OMA" id="RFEFQLG"/>
    <dbReference type="OrthoDB" id="1046649at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="GH16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867797" evidence="1">
        <location>
            <begin position="22"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="219"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="627" mass="70787" checksum="DDD4F49F5A8C3C6D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Y6</accession>
    <name>B8E1Y6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352383.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0469"/>
    <dbReference type="EnsemblBacteria" id="ACK41769">
        <property type="protein sequence ID" value="ACK41769"/>
        <property type="gene ID" value="Dtur_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0469"/>
    <dbReference type="eggNOG" id="ENOG5033A2M">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181401_1_1_0"/>
    <dbReference type="OMA" id="YIRMIFK"/>
    <dbReference type="OrthoDB" id="2034992at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021321">
        <property type="entry name" value="DUF2922"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11148">
        <property type="entry name" value="DUF2922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="76" mass="8751" checksum="9F91764764F5D0AA" modified="2009-03-03" version="1">MATYSSRRYIRMIFKDSGGSNFTIRVPEPKDNITEQEILNAMDIIISQNIFQGRSGDLVEKVDARVIETNISDYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Y7</accession>
    <name>B8E1Y7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582855.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352384.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0470"/>
    <dbReference type="EnsemblBacteria" id="ACK41770">
        <property type="protein sequence ID" value="ACK41770"/>
        <property type="gene ID" value="Dtur_0470"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0470"/>
    <dbReference type="eggNOG" id="ENOG5033AHG">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196603_1_1_0"/>
    <dbReference type="OMA" id="TRINQVD"/>
    <dbReference type="OrthoDB" id="1971409at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012454">
        <property type="entry name" value="DUF1659"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07872">
        <property type="entry name" value="DUF1659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="73" mass="8153" checksum="0AA686981EC94FC2" modified="2009-03-03" version="1">MPVQSLPYNSRLILRVQIGVQSGNPVLRNRSFNNIKPDATDEAVYTVAQVLGSLQKYPVVKVVRTNDEEIIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E211</accession>
    <name>B8E211_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582879.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352408.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0501"/>
    <dbReference type="ESTHER" id="dictd-b8e211">
        <property type="family name" value="Bacterial_EstLip_FamX"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41794">
        <property type="protein sequence ID" value="ACK41794"/>
        <property type="gene ID" value="Dtur_0501"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0501"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.533"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033707_0_0_0"/>
    <dbReference type="InParanoid" id="B8E211"/>
    <dbReference type="OMA" id="NWWTQSG"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024981">
        <property type="entry name" value="DUF3887"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13026">
        <property type="entry name" value="DUF3887"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3887" evidence="2">
        <location>
            <begin position="27"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="191"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="436" mass="49951" checksum="BCA83DAE524A64AA" modified="2009-03-03" version="1">MRKILIIFLMVLLFTIIYAQEDEKAISEKFIYLLVSGRYEEARDFFDPSVKSMISVEKLEELWKSLEKQVGDFRSILGYRTEGSGVYRIVFVTCEFNLMDVDIRLVFANKKIVGMFFQPAPPRKSYTPPSYVDVNSFVEKDIKIGKEFSLPGKLVIPKGKGPFPVVILVHGSGPNDMDETIGPNKPFRDIAWGLGTLGIATLRYDKRTKIYPEKFSEYKDGFTVWEEVIEDVLFVIEFLKTQEEIDSNKIFILGHSLGGMLAPRIATYTKDVTGLIIMAGPTRSLEDLILAQTEYLFGIDGTIDEKEKAQLEIIKGEIQKIKDPDVSKKYPLSFMILGAPVKYWADLKSYDPVLTLSSLEIPALILQGERDYQVTLKDFEGWSKLSPFERITLKTYPKLNHLFMEGEEKSIPQEYYVESHIPEYVIKDIANWIKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E248</accession>
    <name>B8E248_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hemolysin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583408.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352939.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1045"/>
    <dbReference type="EnsemblBacteria" id="ACK42325">
        <property type="protein sequence ID" value="ACK42325"/>
        <property type="gene ID" value="Dtur_1045"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1045"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1082"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058015_3_0_0"/>
    <dbReference type="InParanoid" id="B8E248"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="OrthoDB" id="1670446at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="2">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="271" mass="30500" checksum="89389D8DA1F138B7" modified="2009-03-03" version="1">MKEKERLDVLLVKRGFFESREKARAAVIAGIVKVNGNVVIKPDLKIPIDSLIEIKENIPYVSKGGFKLKKAIDTFEVDVKGKIAVDIGASTGGFTDCLLQEGALRVYAVDVGKGQLHEKLRRDSRVILKEGINARYLKEGDIPEKVDIVTIDVSFISVLKIFPSIKSFLHGESIIIPLIKPQFEASPKEVSRGGIVKNIDVHIKILENIKETLKEQGFYMQKLTYYLSKEGKGNIEYPSLFTLKPEREIEEVEIEKVVQEAFSNWKLSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E254</accession>
    <name>B8E254_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Extracellular solute-binding protein family 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1051</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial solute-binding protein 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583414.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352945.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1051"/>
    <dbReference type="EnsemblBacteria" id="ACK42331">
        <property type="protein sequence ID" value="ACK42331"/>
        <property type="gene ID" value="Dtur_1051"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1051"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1088"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_18_2_0"/>
    <dbReference type="InParanoid" id="B8E254"/>
    <dbReference type="OMA" id="QPTKWDG"/>
    <dbReference type="OrthoDB" id="847343at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018313">
        <property type="entry name" value="SBP_3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01039">
        <property type="entry name" value="SBP_BACTERIAL_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="PBPb" evidence="4">
        <location>
            <begin position="33"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="PBPe" evidence="5">
        <location>
            <begin position="33"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="257" mass="28869" checksum="263B83581BCDC607" modified="2009-03-03" version="1">MRKGIIISFLFFLLVLYPVLGAGAVERIKKVGVLKVGSDVAYAPFEFMEGDKPVGFDIDIAQEIAKALGVKLQVINTSFDGIIAALKAKKFDIIISAMTITEERKKEIDFSIPYYDSGQIIVVRSENKDIKSEKDLKDKVVGVQLGTTGELTAKKLKDQIGIKEIRSYETIPEAFMDLELGRLDAVINDLPVSLYYSKNNPKLKCVGKPFTIEQYGIAVRKEDKDLLKKINEILINLKKTGKYNQIYKKWFGVEPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E295</accession>
    <name>B8E295_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ion-translocating oxidoreductase complex subunit G</fullName>
            <ecNumber evidence="6">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rnf electron transport complex subunit G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnfG</name>
        <name evidence="8" type="ordered locus">Dtur_1093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnfG family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583455.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352986.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1093"/>
    <dbReference type="EnsemblBacteria" id="ACK42372">
        <property type="protein sequence ID" value="ACK42372"/>
        <property type="gene ID" value="Dtur_1093"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1093"/>
    <dbReference type="eggNOG" id="COG4659">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077882_1_1_0"/>
    <dbReference type="InParanoid" id="B8E295"/>
    <dbReference type="OMA" id="PYIEANQ"/>
    <dbReference type="OrthoDB" id="1381933at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00479">
        <property type="entry name" value="RsxG_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007329">
        <property type="entry name" value="FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010209">
        <property type="entry name" value="Ion_transpt_RnfG/RsxG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36118">
        <property type="entry name" value="PTHR36118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04205">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006091">
        <property type="entry name" value="E_trnsport_RnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00900">
        <property type="entry name" value="FMN_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01947">
        <property type="entry name" value="rnfG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FMN_bind" evidence="7">
        <location>
            <begin position="94"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="6">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="178" mass="19615" checksum="44CB31491AFD6955" modified="2009-03-03" version="1">MKNILRYGLTLMLICAIAAGVLAYTYENTQKVIELNKAKERNLLLKELLPEAIEFVPLSNKPKNIDPLVNINEIYIGKRDGKEVGKVWEVSTKGYSSDIVLLVAVNDKGVIEKVKVVSQQETPGLGTEVTKDNFLGQFIGKKEPNLEAKKNITPVSGATISSSAVVRAINEVLKHNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2C3</accession>
    <name>B8E2C3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Histidinol dehydrogenase</fullName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1121</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583483.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353014.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1121"/>
    <dbReference type="EnsemblBacteria" id="ACK42400">
        <property type="protein sequence ID" value="ACK42400"/>
        <property type="gene ID" value="Dtur_1121"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1121"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1158"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_3_0"/>
    <dbReference type="InParanoid" id="B8E2C3"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="417" mass="46997" checksum="992270227FC91704" modified="2009-03-03" version="1">MINVIKGLDFNLKLLRMEESKVKEVEKEVDFIVEEIRTKGDLALHNFSLKFDNYDSKKYGFKISVPEIDLSNDFATAIKVMIERVKNYYIHEYKNSWFYKDGESILGQLIVPVDSVLLYVPGGKASYPSTVVMGLIPAMIAGVKNLYVTTPPSKREDRNLLYTLRLLGIKELYVLGGAHAISAFAYGTESIPKVDMIIGPGNLYVALAKKRVFGDVNIDGIFGPSEILVWINYRGKDLNLRKIVCDFLAQLEHSPYDRGWMILPEELLDKVMGLIKEEVEGSGRGDILKEAIKNSFLIIEEDEERAINLINQIAPEHLEIIDFSGERHIPYIKNAGAIFINHSSIFGDFIAGPSHILPTGGSAKFSSGLSVNSFLKRISFVKLSAKEQKILAEYGSIIAREEGFYMHEKSLRNYKEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2D4</accession>
    <name>VATE_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type proton ATPase subunit E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">V-ATPase subunit E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpE</name>
        <name type="ordered locus">Dtur_1504</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583856.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353392.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2D4"/>
    <dbReference type="SMR" id="B8E2D4"/>
    <dbReference type="STRING" id="515635.Dtur_1504"/>
    <dbReference type="EnsemblBacteria" id="ACK42778">
        <property type="protein sequence ID" value="ACK42778"/>
        <property type="gene ID" value="Dtur_1504"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1504"/>
    <dbReference type="eggNOG" id="ENOG503450Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1438999_0_0_0"/>
    <dbReference type="OMA" id="QHINTAG"/>
    <dbReference type="OrthoDB" id="2135412at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000119530" description="V-type proton ATPase subunit E">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00311"/>
        </source>
    </evidence>
    <sequence length="188" mass="21971" checksum="021099A16208DE67" modified="2009-03-03" version="1">MALEKIIEKLENEKKVKIEELRKKREKEYEDFVAKKEKELEEWKEQQRKNLKESLNREESTLLSQLRLKYNTEKARIEAETVNRVKLLLLEKIKSLSNELYNGIWDGFVEKESVKGGEIILAKGEDKIDVDHFCKKYGLVLGKDRVEGKGGFVIQKDNLVIDLTIDTIVEELVNKNILEIAQILRGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2E4</accession>
    <name>B8E2E4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone family protein DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012547195.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353402.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1514"/>
    <dbReference type="EnsemblBacteria" id="ACK42788">
        <property type="protein sequence ID" value="ACK42788"/>
        <property type="gene ID" value="Dtur_1514"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1514"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1563"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_3_1_0"/>
    <dbReference type="InParanoid" id="B8E2E4"/>
    <dbReference type="OMA" id="PAHEGIN"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="91" mass="10094" checksum="6F8A2E6F1405E1C6" modified="2009-03-03" version="1">MKKAEFIAKVAEKAKITKKEATKVVNAVLETITEALSKGDTVQFVGFGTFSVRKRAAREGRNPRTQQPIKIPATKVPVFRPGKELREAVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2F1</accession>
    <name>B8E2F1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polynucleotide adenylyltransferase/metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583871.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353409.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1521"/>
    <dbReference type="EnsemblBacteria" id="ACK42795">
        <property type="protein sequence ID" value="ACK42795"/>
        <property type="gene ID" value="Dtur_1521"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1521"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_6_2_0"/>
    <dbReference type="InParanoid" id="B8E2F1"/>
    <dbReference type="OMA" id="GWTFHGH"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="236"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="469" mass="55678" checksum="86C42BDFDFDB749F" modified="2009-03-03" version="1">MDKELYKILYVVREYAKVYNITPYIVGGFIRDYLLGKNPRDIDFLIHPFNVDFIDHIVKILNGRLVILDEERKYFRIVIKNKEKTFVLDFTPIYQQNLLFEIIRRDFTINSIVLNLKNFKIFDPLRGLEDLERNVIKLSSPNSLREDPLRILRVFRFGASGFKIDKNVLENIEKNSQNLSKIKPERIHEEIYKILKNPFTSHFWKEMEEYGVLKEIFPELSKIKYIPWSKPHHENPLDHSITTLYVLEDLFYNMDFLFPSIKKDLENYFSKNLFSEFTKKETLKLTSLLHDIGKSKTYSIDEENLVHYYGHSKVGAEMIKEIAERLKLSNKELTFIQKLIRNHMYLIDLIKNPEIKTIHKLISRVNEDVPSLVFLFISDQIAIKGNFENKDYFEKLLEEFFKLKNIPKPLLSGHEIMQLFNLNPSPIVGTLKEKLIEAQIEERVKTKEEAIKFLREILENERYSSGNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2H0</accession>
    <name>B8E2H0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583889.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353428.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1540"/>
    <dbReference type="EnsemblBacteria" id="ACK42814">
        <property type="protein sequence ID" value="ACK42814"/>
        <property type="gene ID" value="Dtur_1540"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1540"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1589"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_3_0"/>
    <dbReference type="InParanoid" id="B8E2H0"/>
    <dbReference type="OMA" id="TIWYSIA"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="105" mass="12174" checksum="9ED3023A868AE5D6" modified="2009-03-03" version="1">MPKKENYTALSDEALQNMSDILKILAHPLRIKLIFILAQNSATVSDLLKILNVRQPNLSQHLTLLKRVKLLKTKREGKSVYYQLSHPEIRDLLESINEITKEIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2J0</accession>
    <name>B8E2J0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Lon protease</fullName>
            <ecNumber evidence="5 6">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lon</name>
        <name evidence="13" type="ordered locus">Dtur_1560</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 9">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="5">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6 9 10">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="5 6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583909.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353448.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1560"/>
    <dbReference type="MEROPS" id="S16.001"/>
    <dbReference type="EnsemblBacteria" id="ACK42834">
        <property type="protein sequence ID" value="ACK42834"/>
        <property type="gene ID" value="Dtur_1560"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1560"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1609"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_0"/>
    <dbReference type="InParanoid" id="B8E2J0"/>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="12">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="11">
        <location>
            <begin position="597"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7 9">
        <location>
            <position position="727"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <begin position="360"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="792" mass="89517" checksum="831829734D1444F8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2J6</accession>
    <name>B8E2J6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583915.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353454.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1566"/>
    <dbReference type="EnsemblBacteria" id="ACK42840">
        <property type="protein sequence ID" value="ACK42840"/>
        <property type="gene ID" value="Dtur_1566"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1566"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1615"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="InParanoid" id="B8E2J6"/>
    <dbReference type="OMA" id="CEGYRRP"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="240" mass="26997" checksum="674F16D007186695" modified="2009-03-03" version="1">METILQVEDLKKSYGKIEALKGLSFEVKKGEVFALIGPNGAGKTTTLRIVATLLTPSEGNVVFMGKNLKEHADFVRENISYLPEEAGAYKNMRGLEYLRFMATFYAKNERDVEIFINRAKEISGLSDRLSDKIGTYSKGMIRKLLLARALMTKPALAILDEPTSGLDVMNALEIREIIREYVKEGTSVLLSSHNMLEIEFLSDRVALIDKGRILEVGTAEELKEKYSAKNLEEVFRRVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2J7</accession>
    <name>B8E2J7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583916.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353455.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1567"/>
    <dbReference type="EnsemblBacteria" id="ACK42841">
        <property type="protein sequence ID" value="ACK42841"/>
        <property type="gene ID" value="Dtur_1567"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1567"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_3_1_0"/>
    <dbReference type="InParanoid" id="B8E2J7"/>
    <dbReference type="OMA" id="QRMEIIK"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900376">
        <property type="term" value="P:regulation of secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="144" mass="17170" checksum="66492600D7815C67" modified="2009-03-03" version="1">MSLKESLKERGIRLSKPRLMVLEFFENNPSGHFSINEIYENLKKQSKNISFTSVYRTCKLLERLGYIKAITFEERHVHYESNSKPHLHIQCIYCGKREEREFKNWNEILKILPVDEKEYLITSCNINILGVCKECKEKINKKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2J8</accession>
    <name>B8E2J8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FeoA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583917.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353456.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1568"/>
    <dbReference type="EnsemblBacteria" id="ACK42842">
        <property type="protein sequence ID" value="ACK42842"/>
        <property type="gene ID" value="Dtur_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1568"/>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150646_6_3_0"/>
    <dbReference type="InParanoid" id="B8E2J8"/>
    <dbReference type="OMA" id="IYVKTLD"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="79" mass="8433" checksum="367C94E01D3DC2C8" modified="2009-03-03" version="1">MIKKLIEMNKGQKGRVVAIRGGRGKILRLAEMGITPGEEVILLQKSLGPVIIKVKDTNLALGKGLAESILVEVGENGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2K5</accession>
    <name>B8E2K5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ordered locus">Dtur_1575</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583924.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353463.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1575"/>
    <dbReference type="EnsemblBacteria" id="ACK42849">
        <property type="protein sequence ID" value="ACK42849"/>
        <property type="gene ID" value="Dtur_1575"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1575"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1623"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_2_0_0"/>
    <dbReference type="InParanoid" id="B8E2K5"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="154"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="311" mass="34670" checksum="0EB8FCF4571AF4F1" modified="2009-03-03" version="1">MWKRKDLIGIEELSREEIEVVIETALSMKDILKRPIKKVPTLRGRTICTLFYEPSTRTRSSFELAAKYLSADTVSIATATSSVQKGESLLDTVKTLEAMGIDLFIIRHSASGVPSFIAKNIKAGVINAGDGMHEHPTQALLDVFTVYEKKGKLEGLKIAIVGDIFHSRVARSNIYAWNKLGSNVILCGPPTLIPPYIENLNVKVTYDLNEAIEDADIIYVLRLQLERQKRGLFPTLREYHMFYGINQERIKKAKKDVLVMHPGPMNRGVEISSEVADSLISVINEQVTNGVAVRMALLYLMLGGKSDENPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2L1</accession>
    <name>B8E2L1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353469.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1581"/>
    <dbReference type="EnsemblBacteria" id="ACK42855">
        <property type="protein sequence ID" value="ACK42855"/>
        <property type="gene ID" value="Dtur_1581"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1581"/>
    <dbReference type="HOGENOM" id="CLU_3182968_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="46" mass="5658" checksum="72872429A0BA7414" modified="2009-03-03" version="1">MCWYFGFPFWGTPWFLGGPFMMFVGLIFWVFVFGIFFYLIKRNTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2M7</accession>
    <name>B8E2M7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clp domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583946.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353485.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1598"/>
    <dbReference type="EnsemblBacteria" id="ACK42871">
        <property type="protein sequence ID" value="ACK42871"/>
        <property type="gene ID" value="Dtur_1598"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1598"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1841946_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2M7"/>
    <dbReference type="OMA" id="QYEISPV"/>
    <dbReference type="OrthoDB" id="2090401at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="3">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="139" mass="15950" checksum="817FA3806C8134FF" modified="2009-03-03" version="1">MKTLKFKSESIILNAEELVLTFSSPYMDVEHLLLSIINDKNNKACKILQKIGVDLRKIKTELEKELRNRKTDQYEISPVNQKIFEIFNYAQDFAEKLGREIVDAEHLLLGILKESSSFASKLLFDSGVSVERVLSEIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2P0</accession>
    <name>B8E2P0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Epoxyqueuosine reductase QueH</fullName>
            <ecNumber evidence="5 12">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Queuosine biosynthesis protein QueH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">queH</name>
        <name evidence="13" type="ordered locus">Dtur_1611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the QueH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="5 12"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583959.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353498.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1611"/>
    <dbReference type="EnsemblBacteria" id="ACK42884">
        <property type="protein sequence ID" value="ACK42884"/>
        <property type="gene ID" value="Dtur_1611"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1611"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1660"/>
    <dbReference type="eggNOG" id="COG1636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088177_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2P0"/>
    <dbReference type="OMA" id="PNIHPYT"/>
    <dbReference type="OrthoDB" id="1078220at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02089">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003828">
        <property type="entry name" value="QueH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36701">
        <property type="entry name" value="PTHR36701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02677">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="182" mass="22018" checksum="9583036B20C0EDF7" modified="2009-03-03" version="1">MTDKRLFLHICCAPCLTYPLKRLREEGFDITGFWYNPNIHPYTEYLMRLNTLKDFAEKQSLPVVYEDDYALEEFIRQVVYREKDRCPVCYYMRLKKTVEKAKELGFDLFSTTLLVSPYQKHDLIKEIANYLANEYKIEFYYEDFRVGYREGVNLSKEYGLYRQKYCGCIYSEKDRYYKGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Q5</accession>
    <name>B8E2Q5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1626</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583974.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353513.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1626"/>
    <dbReference type="EnsemblBacteria" id="ACK42899">
        <property type="protein sequence ID" value="ACK42899"/>
        <property type="gene ID" value="Dtur_1626"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1626"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_338230_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2Q5"/>
    <dbReference type="OMA" id="LQVYEFK"/>
    <dbReference type="OrthoDB" id="1994961at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_23" evidence="2">
        <location>
            <begin position="6"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="195"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="586"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="764"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="978" mass="114980" checksum="778A144FB84B5D53" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Q9</accession>
    <name>B8E2Q9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">leuC</name>
        <name evidence="8" type="ordered locus">Dtur_1630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583978.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353517.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1630"/>
    <dbReference type="EnsemblBacteria" id="ACK42903">
        <property type="protein sequence ID" value="ACK42903"/>
        <property type="gene ID" value="Dtur_1630"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1630"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1679"/>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_0"/>
    <dbReference type="OMA" id="GCGPCMG"/>
    <dbReference type="OrthoDB" id="749418at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="418" mass="44886" checksum="844C2B0CD8741F58" modified="2009-03-03" version="1">MGKTIAEKIFSAHVGRDVKAGDLVIAKLDALMGQDGTSPLAIKVFEELGGEKVVNADRVLLVMDHSVPPPNEGVANLHKLMRDFAEKYGTQITEFGEGVCHQVFMERGLATPGSLVIGADSHTCTYGVLNCFSTGVGSSELAAAMYTGKLWFKVPSTVKIILNGKLSKGVVSKDVILFLAGYFKADGLTYKAIEFDGEVINNLSIDGRATITNMVVEMGAKAGIMPFDEKTKEFFKSIGLPQEKGVEADPDAEYEAVYEFNLSNLEPQVALPHTVDNVYPISQIENIKIHEAFIGTCTNGRLEDLRLAASILKGRKVAKNVKMIVTPASKRIFMQAMKEGLVDIFLEAGAIVTNPGCGPCVGTHQGVPADGENIISTANRNFKGRMGNNKAFIYLASPLTVAASAVLGKITDPRELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2X3</accession>
    <name>B8E2X3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_1194</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583555.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353087.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1194"/>
    <dbReference type="EnsemblBacteria" id="ACK42473">
        <property type="protein sequence ID" value="ACK42473"/>
        <property type="gene ID" value="Dtur_1194"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1194"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1231"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_7_0_0"/>
    <dbReference type="InParanoid" id="B8E2X3"/>
    <dbReference type="OMA" id="KSWDFHV"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
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    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
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        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="Citramal_synthase"/>
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        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
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        <property type="entry name" value="PYR_CT"/>
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        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
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        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
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    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="524" mass="57978" checksum="273D954605EE6393" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2X4</accession>
    <name>B8E2X4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Galactokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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        <property type="protein sequence ID" value="ACK42474"/>
        <property type="gene ID" value="Dtur_1195"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1195"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1232"/>
    <dbReference type="eggNOG" id="COG0153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="PVCYNLR"/>
    <dbReference type="OrthoDB" id="1388391at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Galactokinase"/>
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        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
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        <property type="entry name" value="GalKase_N"/>
    </dbReference>
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        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
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        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="9">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="7">
        <location>
            <begin position="108"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="8">
        <location>
            <begin position="281"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="380" mass="43840" checksum="5023E9D0E16290C8" modified="2009-03-03" version="1">MRSNFEKIFGSKEGFRGFRAPGRVNLIGEHTDYHYGFVLPISINKFFYFYLKRNTENKFRVFSENFNDYFEFDYSDLIFNKEKPWVNYLMGVINEIRKIKGEIPYFDAYLYGEIPMGAGLSSSAAYEVSVAYGISEYFNLNIEKKEIAKLSQRAENNFVGAPCGIMDQFIATFGRENTALLIDTLTLDYEHIPFDIKSKELRLAVVDTKVKHSIAGEGYSTRRREGEEALKMLQKHLNINSLRELDEKAFELSQEILPSPLKERVAHVYNENKRVLNFVNDLKNNKWENLPKYMLDSHLSLKNLYEVTCEELDFLVEKALEYGAFASRMTGGGFGGSTINLVPETIIEEWIGKITTSYEKKFGFKPDILILETSNGVREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Y7</accession>
    <name>B8E2Y7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">infB</name>
        <name evidence="10" type="ordered locus">Dtur_1208</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583569.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353101.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1208"/>
    <dbReference type="EnsemblBacteria" id="ACK42487">
        <property type="protein sequence ID" value="ACK42487"/>
        <property type="gene ID" value="Dtur_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1208"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1246"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_5_1_0"/>
    <dbReference type="InParanoid" id="B8E2Y7"/>
    <dbReference type="OMA" id="NRDNRTG"/>
    <dbReference type="OrthoDB" id="347113at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="174"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="G-domain" evidence="7">
        <location>
            <begin position="177"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="283"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="658" mass="72980" checksum="59D29C64EAC11356" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Y8</accession>
    <name>B8E2Y8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583570.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353102.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1209"/>
    <dbReference type="EnsemblBacteria" id="ACK42488">
        <property type="protein sequence ID" value="ACK42488"/>
        <property type="gene ID" value="Dtur_1209"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1209"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1247"/>
    <dbReference type="eggNOG" id="COG1550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149981_4_0_0"/>
    <dbReference type="InParanoid" id="B8E2Y8"/>
    <dbReference type="OMA" id="MYVGALE"/>
    <dbReference type="OrthoDB" id="1813824at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="93" mass="10752" checksum="947D5058764E94FE" modified="2009-03-03" version="1">MLIGVCRVIISIPDSFSLKEKRKVKRSIVDRVRAKFNVSIAEVDSQEIWNELVLGISMVSTESKHIYEVMSEIIKLIEEQKEAELIDYEIDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E308</accession>
    <name>B8E308_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CutA1 divalent ion tolerance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583590.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353122.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1230"/>
    <dbReference type="EnsemblBacteria" id="ACK42508">
        <property type="protein sequence ID" value="ACK42508"/>
        <property type="gene ID" value="Dtur_1230"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1230"/>
    <dbReference type="eggNOG" id="COG1324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098807_1_2_0"/>
    <dbReference type="InParanoid" id="B8E308"/>
    <dbReference type="OMA" id="VYTTFPD"/>
    <dbReference type="OrthoDB" id="1801957at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="PTHR23419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="102" mass="11786" checksum="C160D883376A892D" modified="2009-03-03" version="1">MILTVVTINSLENAEKIANVLLDEKLCACVNIIPEAKSIYIWQGEKKVEMEVIMLIKTEKSKFSELVKRIRELHPYKLPEIIGIPINYGLPEYLEWIKSSLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E335</accession>
    <name>FOLD_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="1">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">folD</name>
        <name type="ordered locus">Dtur_1636</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="1"/>
    <dbReference type="EC" id="3.5.4.9" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583984.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353523.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E335"/>
    <dbReference type="SMR" id="B8E335"/>
    <dbReference type="STRING" id="515635.Dtur_1636"/>
    <dbReference type="EnsemblBacteria" id="ACK42909">
        <property type="protein sequence ID" value="ACK42909"/>
        <property type="gene ID" value="Dtur_1636"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1636"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1685"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_0"/>
    <dbReference type="InParanoid" id="B8E335"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000196768" description="Bifunctional protein FolD">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <sequence length="281" mass="31034" checksum="2941C8D0C156DE39" modified="2009-03-03" version="1">MGVILEGKPVAEKLEKEIKEKIQFYKSQGVIPTLCIVKVGKNAEAEAYAKSIEKFFSKIGINIERKNFNEEISLVDFKKIMKELEEDSAIHGVLILRPLPEELERGKAFQFLPTKKDVEGVTYENLGRLLVGEDSFHPCTPQAVLELLDFYQIPVEGKNVVVVGRSISVGKPLSLLLLNRNATITVCHSKTKNLVEFTKKAEILIVAIGKPYFVGKDMVGEGQVIIDVGTNVVDGKLVGDVNFEEVKDKVEYITPVPGGIGVITTRVLAMNLLKAVKKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E345</accession>
    <name>B8E345_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PsbP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583994.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353533.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1646"/>
    <dbReference type="EnsemblBacteria" id="ACK42919">
        <property type="protein sequence ID" value="ACK42919"/>
        <property type="gene ID" value="Dtur_1646"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1646"/>
    <dbReference type="eggNOG" id="COG5435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1508313_0_0_0"/>
    <dbReference type="OMA" id="PADEGFM"/>
    <dbReference type="OrthoDB" id="1671680at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019898">
        <property type="term" value="C:extrinsic component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009654">
        <property type="term" value="C:photosystem II oxygen evolving complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002683">
        <property type="entry name" value="PsbP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01789">
        <property type="entry name" value="PsbP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PsbP" evidence="1">
        <location>
            <begin position="26"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="178" mass="20420" checksum="274C6A75E5932805" modified="2009-03-03" version="1">MRKLLKLLLFISLILCFSFNILLADTNKYVDEKLGFSIVPPEGWEVKDGKPYNLAVMFVGPADEGFMPNFNINVVNLPGEVTEINEDLISEIKVQLEAVGEYYGSLEFISEGVRDVSKYKGYEIVYTLNVDKGLSFEQKQVYIIYEGRFYIFTFTSLKDNFEKNLPAFEKSLSTFEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E371</accession>
    <name>B8E371_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mov34/MPN/PAD-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584020.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353559.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1673"/>
    <dbReference type="EnsemblBacteria" id="ACK42945">
        <property type="protein sequence ID" value="ACK42945"/>
        <property type="gene ID" value="Dtur_1673"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1673"/>
    <dbReference type="eggNOG" id="COG1310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_4_2_0"/>
    <dbReference type="InParanoid" id="B8E371"/>
    <dbReference type="OMA" id="GAHYVLV"/>
    <dbReference type="OrthoDB" id="1811367at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="2"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="139" mass="16181" checksum="20292D963D211207" modified="2009-03-03" version="1">MEIYLPKDIFKMLVVHSIHEYPFEACGILGGEVGASQIIVKSYFTTKNVSSDPYREYLIDPWEEIKILRFIEKIGQNFIGVYHSHPEGGQYLSEKDKNSMIPEICYLVFSLRINTNPTIKLDAYFKKDEDILNLPIRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E372</accession>
    <name>B8E372_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1674</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353560.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1674"/>
    <dbReference type="EnsemblBacteria" id="ACK42946">
        <property type="protein sequence ID" value="ACK42946"/>
        <property type="gene ID" value="Dtur_1674"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1674"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_1_0"/>
    <dbReference type="InParanoid" id="B8E372"/>
    <dbReference type="OMA" id="QRRFHVM"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43273">
        <property type="entry name" value="PTHR43273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="326" mass="37603" checksum="4DF45261CAAFFE2B" modified="2009-03-03" version="1">MFITNIIWILDIRCNLNCPHCYVHRRNWERRISKKRALKLIEEVKELSIKSIDFTGGEPLLIEDLFEYIEKARSLGLEVSLNSNVLLLTREIAKFLKDNNVYLYVSIDGSNRETFEKMRGRGNFDKLLNSIDLINEFAIPYSIIFSISSLNYYDAKNMVKFAKNIGAKDLCMIPVIPSGEAKNTGIYIDSKILIDTIREVSYEAEKEEYPVILWCVPFMKSMKLSNYVIVDECHVFDCIDLAPTGDIMLCDVLDMPLSEIRTKSLSEALREVERNGFYKLLKERYKLCFGCGVAEFCKGGCYARSYIVERDISKPDPYCPKVLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E388</accession>
    <name>B8E388_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase domain protein hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1690</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584037.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353576.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1690"/>
    <dbReference type="EnsemblBacteria" id="ACK42962">
        <property type="protein sequence ID" value="ACK42962"/>
        <property type="gene ID" value="Dtur_1690"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1690"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064956_1_0_0"/>
    <dbReference type="InParanoid" id="B8E388"/>
    <dbReference type="OMA" id="TYENMHF"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="237" mass="27749" checksum="A2026CD0B2A54109" modified="2009-03-03" version="1">MLKAILFDLDGTLLMNNFDLFMKNYFSLLMEEFKKIGDEKDLFKNLNFAIEKMLANKGPKTNYDVFWEEFTKLTGKDRKYMEDFFMDFYSKKFPLLKELSQARANSYAKEVVEKSFELGLKVVIATNAVFPLIAIKERLKWANLINYPYDLITSMEVMHSCKPNLEYYKEILERINVTPEKTLMVGNDIKEDLSASKLGILTFLYTPHNNLILNLDHKPDFMGDLKDLFKLLPLLSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E395</accession>
    <name>NRDR_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nrdR</name>
        <name type="ordered locus">Dtur_1697</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584044.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353583.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E395"/>
    <dbReference type="SMR" id="B8E395"/>
    <dbReference type="STRING" id="515635.Dtur_1697"/>
    <dbReference type="EnsemblBacteria" id="ACK42969">
        <property type="protein sequence ID" value="ACK42969"/>
        <property type="gene ID" value="Dtur_1697"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1697"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1748"/>
    <dbReference type="eggNOG" id="COG1327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108412_0_0_0"/>
    <dbReference type="InParanoid" id="B8E395"/>
    <dbReference type="OMA" id="YRFTTYE"/>
    <dbReference type="OrthoDB" id="1551627at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_1000124497" description="Transcriptional repressor NrdR">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-cone" evidence="1">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <sequence length="150" mass="17726" checksum="7047B41425D565AC" modified="2009-03-03" version="1">MRCPFCGYEDTFVIDTREIEDQKVIRRRRECPNCKNRFTTYERIEEKPIMVIKKDGRREPFDRNKLLAGLQRAVVKRNIDNEKLEAIIDEIITNIRKQGVSEITSKEIGKMVLEKLKDLDAVAYVRFASVYQEFSSLEEFAKLLSQMKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3A7</accession>
    <name>B8E3A7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584056.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353595.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1709"/>
    <dbReference type="EnsemblBacteria" id="ACK42981">
        <property type="protein sequence ID" value="ACK42981"/>
        <property type="gene ID" value="Dtur_1709"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1709"/>
    <dbReference type="eggNOG" id="COG3359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073770_1_0_0"/>
    <dbReference type="InParanoid" id="B8E3A7"/>
    <dbReference type="OMA" id="HEDLMYR"/>
    <dbReference type="OrthoDB" id="1985371at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="164" mass="19490" checksum="389440BCE3DB8700" modified="2009-03-03" version="1">MKKYEAYLDIETTGLSPIYSDITVIGIYLENKEESILIQLIGKEITSYNLLYIIEKVHTIYTYNGSRFDLPFIHSKLGIDLEKHVLHEDLMYRCWERGLYGGLKKVEEKLGIERKLKEVNGRIAVILWYRYTKHNDYNALNLLLEYNREDVMNLKTLREKLYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3C0</accession>
    <name>B8E3C0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584069.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353608.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1722"/>
    <dbReference type="EnsemblBacteria" id="ACK42994">
        <property type="protein sequence ID" value="ACK42994"/>
        <property type="gene ID" value="Dtur_1722"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1722"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_0"/>
    <dbReference type="InParanoid" id="B8E3C0"/>
    <dbReference type="OMA" id="MPYYILA"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="107"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="333" mass="37850" checksum="40739F3258B43656" modified="2009-03-03" version="1">MLKRYLIPRFLQYLLVIFVGVTIVFFVPRFTPVDPVQQMISTIMKMGTYLDPKAVEQMTESLKELYGLKGSLFEQYINFWLRLFRGDFGPSLFRFPIPVIKLIGDSLPWTVGLLSVSTLLSWIIGNILGGIVGFYYDKRWARILEGIAMFIRPIPYYVFALIILVIFAYILKWFPLGGGMPIGVRPSFSLQFILELFRYAFLPLISMMILGIAVTLQTMRLIVSNVVKEDFVTYARAGGVKKRIITFKYVIRNAMLPQVTNLALSMGQIFSGALITEIVFSYPGMGTLLYNAIATGDFNLIMGIATISIVGISSFILIIDLLYPLFDPRVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3C4</accession>
    <name>B8E3C4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HrcA_DNA-bdg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584073.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353612.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1726"/>
    <dbReference type="EnsemblBacteria" id="ACK42998">
        <property type="protein sequence ID" value="ACK42998"/>
        <property type="gene ID" value="Dtur_1726"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1726"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110273_0_0_0"/>
    <dbReference type="OMA" id="ATAYDIM"/>
    <dbReference type="OrthoDB" id="1747399at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA_DNA-bdg" evidence="2">
        <location>
            <begin position="3"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="195" mass="22486" checksum="37DE8C18F254EFA1" modified="2009-03-03" version="1">MSLTERRRQFLQALENLYKKNKRPIHYAEIAKELSVSPATAYDIMQALYKNGYVEAVYLENSVNNKRGRGKIFFKPKEEKEDINTSITSIQELNKYPISIAIILSLILTILKEAKFSKELKSIISLILGVFQSNLELVLILLPVLMVGYAGKKIYEIIPKNKIKAYFEDYIKSLNQLAVEERKLLLNFILNVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3C7</accession>
    <name>B8E3C7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 43</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1729</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584076.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353615.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1729"/>
    <dbReference type="CAZy" id="GH43">
        <property type="family name" value="Glycoside Hydrolase Family 43"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK43001">
        <property type="protein sequence ID" value="ACK43001"/>
        <property type="gene ID" value="Dtur_1729"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1729"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1781"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009397_1_2_0"/>
    <dbReference type="InParanoid" id="B8E3C7"/>
    <dbReference type="OMA" id="MNPKTGF"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032291">
        <property type="entry name" value="Abn2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16369">
        <property type="entry name" value="GH43_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH43_C" evidence="5">
        <location>
            <begin position="363"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="472" mass="54052" checksum="627A33B1C46634CD" modified="2009-03-03" version="1">MRVINLGLFIVAISFLMLLVGSYSQGIIYPKEPPKIELMDASIVNDESKWSINNVHDPSIIKASNGWYYIYSTDVKAYGIPRPGIQIRKSKDLINWQFVGYVFNDDKYVFKGIPPQAFEWSKASTLWAPDVKFMNNKYYLYYSASTFGKNQSYIGLATANNPEGPWKDEGEVIKTRQGDPVNAIDPCLVFDENGEPWLSYGSFWSGIYIIRIDKKTGKPAEKGFGVNIARRKGTVAGAVEGSYIIYNPKFKKYYLFVSYDSLFSDYNVRVGRADKITGPYVDYNGNPLTDLTLPPEEVGTKILGGYKFENDNGWIAPGHNSVLNDGDNWYIVHHARPALNKNWMYLHIRRMLWTNDGWPVVSPERYTGEIIQEVPQELVIGTWERIVLDPYDKVQSQSKRLILQKDGTFVFGDRKGTWEFTSPNNLSLIWRDSNEKENLLVLASWDWENWRPTLVFTGLNSRGIAIWGKKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3D0</accession>
    <name>B8E3D0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584079.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353618.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1732"/>
    <dbReference type="EnsemblBacteria" id="ACK43004">
        <property type="protein sequence ID" value="ACK43004"/>
        <property type="gene ID" value="Dtur_1732"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1732"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1784"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_0_0"/>
    <dbReference type="InParanoid" id="B8E3D0"/>
    <dbReference type="OMA" id="MWRLFYT"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867682" evidence="1">
        <location>
            <begin position="26"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="415" mass="46981" checksum="4DFA083E07005BB8" modified="2009-03-03" version="1">MKKILPITVILVTLLLLLSTASSQAKIQITFMTPLSGADGAYMDQIIQNFNKENPDVNVVHMVVGSSVEYKQKLSTGLATKSAPQVLLIRKFDLPMYLNQMKGFTAGDFAKYGINIRDVYPNLLEGLVEDNKYYGIPLDVWIFYMAYNKANFKKAGLDPERPPKTRDEFIKALEALKKVTPKGLTPYYENPTWAWIFVHFLWQFGGDLLTPDFKKPAFKDAAIQTLKFLMDLQERGLFPKAAVDPGPPFQSGQTSVLITGIWTINPWLQALGNNFGYAPCPQVGTKKAVFGGSHIIALPEVMVSDPKVYNAAMKWVKYLWDHALDWYAAGQTPSRRSIATSNELKTKLPHIYAVAQQLPYVKTFQFFPYISEVLDEIAVYLEDVLITRKLTPEQAMERAEKSVQRILDDYWSTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3D5</accession>
    <name>B8E3D5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584084.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353623.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1737"/>
    <dbReference type="EnsemblBacteria" id="ACK43009">
        <property type="protein sequence ID" value="ACK43009"/>
        <property type="gene ID" value="Dtur_1737"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1737"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1124108_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3D5"/>
    <dbReference type="OMA" id="KIHWISF"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002871106" evidence="1">
        <location>
            <begin position="20"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="251" mass="27667" checksum="9F09669ABA5E3E9E" modified="2009-03-03" version="1">MTKKMFFIFLLLIFSICLSGCMKSVTTESATLLAHYEFEDNLSDSTGDFSDGIVIGTKIGETGGSVTYTDGVVGKAVYLDGASGIQLPDNLIHSYKYSIAFWLKADQLTNYTPAFFGCVKNKTNEWLSIPPGGLAAFGGRFQIWSNYNNGSTWFDGLTNVNLEVGKWYHIAVVVNEGELSVYINGEKQALDTRINGQNSLQALFPDLFSNKDAIFTIGVNYWDTPFKGLIDDLRIYSGVLTDSEVLFLASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3E3</accession>
    <name>B8E3E3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CoA-substrate-specific enzyme activase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584092.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353631.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1745"/>
    <dbReference type="EnsemblBacteria" id="ACK43017">
        <property type="protein sequence ID" value="ACK43017"/>
        <property type="gene ID" value="Dtur_1745"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1745"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1797"/>
    <dbReference type="eggNOG" id="COG1924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066597_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3E3"/>
    <dbReference type="OMA" id="GKGANYF"/>
    <dbReference type="OrthoDB" id="1837697at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="5"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="261" mass="27963" checksum="3994B6591589F2E4" modified="2009-03-03" version="1">MKYFLGVDIGSATTKVVLLSSNGTKDNILGYAIRETGSDGNKTALDLIDDLLKTHNISLKDINSIVATGYGRIKVDFTDKSKTEISCHAKGINFLFPDARTVIDIGGQDSKVIKIGKNGAVLDFVMNDKCAAGTGRFLEIMSKVLQVSFDEFGEIHLKTSDYVDITNICTVFAESEIITLISEGVPKEKIIKGINYSVAKRAVALVKRVGIDQEVVMSGGVAKNIGVVKALEELIGVSIKTPHEPQIVGALGAALFAKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3E4</accession>
    <name>B8E3E4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxyglutaryl-CoA dehydratase D-component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584093.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353632.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1746"/>
    <dbReference type="EnsemblBacteria" id="ACK43018">
        <property type="protein sequence ID" value="ACK43018"/>
        <property type="gene ID" value="Dtur_1746"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1746"/>
    <dbReference type="eggNOG" id="COG1775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049730_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3E4"/>
    <dbReference type="OMA" id="ESYFQMI"/>
    <dbReference type="OrthoDB" id="437351at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="408" mass="47151" checksum="0E7F72CCF9E5BB56" modified="2009-03-03" version="1">MSVEKLVYERQNLIKNFVGSFPVYLGAKIFINAKYKEDKVTKISYLYALDLIKYIYGKKSKKVMINIFTPSEIFYALDIYPLLPEVASGFFSALGLLRRALNESEGILGNSDVCSVHRGILGLSKLKVFPTPDFLVSYTKPCFSPIFSFSLIKELNGGEIFVIDSFEDEEYLASQIERIYYELTKRLGVKDGIERLKKVIILSNEAYNYFEEVKELRRDYVVMDGKNFLDYAGMIFSVFGSKYGVEFFKTLRDEIKSRIQKGKIIEPKVRLYWMHLGPYFKTDLFKWLNDKGAYIVFEESTSVSWERLDINNPFESLAKKLINLKAFSSLEDRIKVALENVEKYKAHGVIIFNQWGCRQGSVPTYIIRQKLVREGVPSLVIDGDLVDELNFPKEQIKTRIEAFLEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYG5</accession>
    <name>B8DYG5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase with PAS/PAC sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582433.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351961.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0006"/>
    <dbReference type="EnsemblBacteria" id="ACK41347">
        <property type="protein sequence ID" value="ACK41347"/>
        <property type="gene ID" value="Dtur_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0006"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_488964_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYG5"/>
    <dbReference type="OMA" id="NMKWIND"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902201">
        <property type="term" value="P:negative regulation of bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="342"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="425"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="557" mass="65408" checksum="3195A656C7E0333B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYH7</accession>
    <name>B8DYH7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dnaJ</name>
        <name evidence="10" type="ordered locus">Dtur_0018</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582445.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351973.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0018"/>
    <dbReference type="EnsemblBacteria" id="ACK41359">
        <property type="protein sequence ID" value="ACK41359"/>
        <property type="gene ID" value="Dtur_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0018"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.18"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_0"/>
    <dbReference type="InParanoid" id="B8DYH7"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051085">
        <property type="term" value="P:chaperone cofactor-dependent protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="176"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="202"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="6">
        <location>
            <begin position="216"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="388" mass="43969" checksum="F3336ABCC344BC12" modified="2009-03-03" version="1">MPGKKDYYEILGVPRNATQDEIKQAYRRLVRQYHPDLNKDPGAQEKFKEINEAYEVLSDPQKRAQYDQFGSVGDFSGYGDFQGNWQPGGFDFEDLGRNFEDIFESFFGDSIFGDLFGRRREREKAPRKGQDLRYDINITLEEAAFGGNKEIYITRLETCPTCKGTGVEPGTSPIKCDMCNGTGQVRNMRQTPFGQFVQITTCPKCHGTGQIITNPCHECHGTGKVRKKRKIEFKIPAGVDEGYVIRLPGEGEPGENGGPNGDIYIHVHIIPHKIFKRENENIWMELPLDYLIALLGGEVEVPTLEGKEKIYIKPGTQTGEIITLKGKGIPYLRNKNQRGDQKIVVKITVPQSLSQKEKELLLEIAKIRGINVENNKGFFEQIKESFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYI2</accession>
    <name>B8DYI2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582450.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351978.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0023"/>
    <dbReference type="EnsemblBacteria" id="ACK41364">
        <property type="protein sequence ID" value="ACK41364"/>
        <property type="gene ID" value="Dtur_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0023"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.23"/>
    <dbReference type="eggNOG" id="COG3862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148086_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYI2"/>
    <dbReference type="OMA" id="PRGKEWA"/>
    <dbReference type="OrthoDB" id="1751763at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036593">
        <property type="entry name" value="CPE0013-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012460">
        <property type="entry name" value="DUF1667"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39450">
        <property type="entry name" value="PTHR39450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07892">
        <property type="entry name" value="DUF1667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160148">
        <property type="entry name" value="SSF160148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="135" mass="15251" checksum="4341253755A3A75F" modified="2009-03-03" version="1">MKKNLTCIVCPLGCHLEIEVIHGEIIVKGNKCERGKSYAEEEIKSPKRVLTTTVKIKNGKYNVVPVKTTGPIPKDYLFELLKKLADIEIEAPVPQGFKVLEKVYQEVDVVTTRSMEKREITKNIKDIKNKASNPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYI5</accession>
    <name>B8DYI5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamate synthase alpha subunit domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582453.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351981.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0029"/>
    <dbReference type="EnsemblBacteria" id="ACK41367">
        <property type="protein sequence ID" value="ACK41367"/>
        <property type="gene ID" value="Dtur_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0029"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.30"/>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078510_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYI5"/>
    <dbReference type="OMA" id="PYIEEFC"/>
    <dbReference type="OrthoDB" id="1467316at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00981">
        <property type="entry name" value="arch_gltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035710">
        <property type="entry name" value="Archaeal_gltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012061">
        <property type="entry name" value="Glu_synth_lsu_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006519">
        <property type="entry name" value="GOGAT_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXGXG" evidence="1">
        <location>
            <begin position="16"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="252" mass="28366" checksum="E2143667D2670264" modified="2009-03-03" version="1">MKIIEDAITINGKGLHYKDLNEKIEEKLKEGYRKIKLININGQRYIGAGLTFPEREIEIYGTPGNDLGVFMNGLKIKVYGNSQDGVGNTMNDGEIVIYGSAGDIMGYGMRGGKIFVKGDVGYRVGIHMKEYKDKIPVIVIGGTAGDFLGEYMAGGRVIVLGLNTEKEENLCGYFCSTGIHGGLIYFRGIIPEYKLGKEGKIVEIEEEDKKFIEEHVKKFSEYFEVDFDFIMEKPFVKVIPYNKRPYGKLYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYL4</accession>
    <name>B8DYL4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582482.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352010.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0058"/>
    <dbReference type="EnsemblBacteria" id="ACK41396">
        <property type="protein sequence ID" value="ACK41396"/>
        <property type="gene ID" value="Dtur_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0058"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039511_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYL4"/>
    <dbReference type="OMA" id="TDWMDTT"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="1">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="337" mass="38951" checksum="BD44919ABB738E9D" modified="2009-03-03" version="1">MRVLITGAFGNIGQSAIHELINQGDRVRCFDLKTKKNIRIFKNLKKLYGDGIEVFWGDITKIEDIKKALEGQDVIVHLAFIIPKLSATGLESETVPDIAYKINVIGTKNLISAMEEMPSPKKIIFTSSVHVFGLTQHLDPPRRVDDPVNPPEHYSRHKVECENLIKNSNLTWAIYRLAASLPVNLKLDKGMFDVPLNNRMEYVHTKDVGYAIAKGVRSEKIWGKVLLIGGGPRCWYYYREILEKVLEGIGVGMLPEEAFSNIPFATDWMDTTESENLLHYQRRTIEDYVEDVKKALGYKIFFIKLFRPVVRYILLKRSPYYNRRYIPLKVLWEGYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYS0</accession>
    <name>B8DYS0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352066.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0120"/>
    <dbReference type="EnsemblBacteria" id="ACK41452">
        <property type="protein sequence ID" value="ACK41452"/>
        <property type="gene ID" value="Dtur_0120"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0120"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.126"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_6_0_0"/>
    <dbReference type="InParanoid" id="B8DYS0"/>
    <dbReference type="OMA" id="QPTCSHY"/>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="85" mass="9929" checksum="1CDEC9E2B8BADC3D" modified="2009-03-03" version="1">MIKNLLIILIKFYKKFISPVLPRSCRFYPTCSTYAMEAIERFGPIDGGILAIKRILRCHPFNPGGYDPVPTKEEFLKLKLKRRKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYS1</accession>
    <name>RNPA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease P protein component</fullName>
            <shortName evidence="1">RNase P protein</shortName>
            <shortName evidence="1">RNaseP protein</shortName>
            <ecNumber evidence="1">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnpA</name>
        <name type="ordered locus">Dtur_0121</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582539.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352067.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DYS1"/>
    <dbReference type="SMR" id="B8DYS1"/>
    <dbReference type="STRING" id="515635.Dtur_0121"/>
    <dbReference type="EnsemblBacteria" id="ACK41453">
        <property type="protein sequence ID" value="ACK41453"/>
        <property type="gene ID" value="Dtur_0121"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0121"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.127"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_9_2_0"/>
    <dbReference type="InParanoid" id="B8DYS1"/>
    <dbReference type="OMA" id="RWVREIF"/>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034414">
        <property type="term" value="P:tRNA 3'-trailer cleavage, endonucleolytic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000194634" description="Ribonuclease P protein component">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <sequence length="119" mass="14267" checksum="1EEFACBA931966DE" modified="2009-03-03" version="1">MGLYFFPKEERLKKQEDFLRILREGKPYSLSKNFVVYIRKGAEKRRIGISVNKKVGKAVVRNKIKRLIREVYRLHRPYLKEDIEMLVIVKPGENIKNLDFHKVKEMLIKIWEKAGILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYW1</accession>
    <name>B8DYW1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582578.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352107.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0162"/>
    <dbReference type="EnsemblBacteria" id="ACK41493">
        <property type="protein sequence ID" value="ACK41493"/>
        <property type="gene ID" value="Dtur_0162"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0162"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.168"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_3_0"/>
    <dbReference type="InParanoid" id="B8DYW1"/>
    <dbReference type="OMA" id="NARDYDM"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="84"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="620" mass="72004" checksum="92709C2344A097C2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYX6</accession>
    <name>B8DYX6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cellulase</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582687.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352216.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0276"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41602">
        <property type="protein sequence ID" value="ACK41602"/>
        <property type="gene ID" value="Dtur_0276"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0276"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.289"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018668_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYX6"/>
    <dbReference type="OMA" id="THQGAEW"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006073">
        <property type="term" value="P:cellular glucan metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="335" mass="39259" checksum="87FE4DF826AA11D5" modified="2009-03-03" version="1">MKLKVFLLLALLLFVAGCTSYELKLEMLPLLRGINMGNALEAPREGEWGVVIKDEYFKIIKNAGFSHVRIPIRWSAHADLNPPYTIEKSFFDRVDHVVNEALRNNLFVVINIHHYEEIMQYPEKHKNRFLALWKQIAEHYKDYPNTLIFELLNEPCMNLTSDLWNKYLAEAIKVIRVSNPDRFIVVGPVNWNSVYALRDLRLPKDEKNIIVTFHYYNPFYFTHQGAEWVQPSPPVGVKWWGREDEKAEIDRELDMAVEWSIRNGKVPLYMGEFGAYSKADMDSRVRWTSYVARSAEKRGIAWAYWEFCAGFGAFDPIKNEWRIPLLKALIPETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYZ6</accession>
    <name>B8DYZ6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582707.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352236.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0300"/>
    <dbReference type="EnsemblBacteria" id="ACK41622">
        <property type="protein sequence ID" value="ACK41622"/>
        <property type="gene ID" value="Dtur_0300"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0300"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.316"/>
    <dbReference type="eggNOG" id="COG3333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022936_2_0_0"/>
    <dbReference type="InParanoid" id="B8DYZ6"/>
    <dbReference type="OMA" id="QQPDIVW"/>
    <dbReference type="OrthoDB" id="735109at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01970">
        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="491" mass="52003" checksum="FA8D573B8F2F0E73" modified="2009-03-03" version="1">MINYWIEGLKIALQFNNLLLMLIGTIGGIIVGALPGVTSSMGIILLLPFTYYLDPKSALLMLAGMYSGSMFGGSISAVLLGVPGTPSAAATVIDGYPLGRQGKAGKAIFTALIASFLGGILSGIVLVFLAPLLASFALKFSPIDYFALAIFGLSIIASVSGKYLLKGIISGLLGLFISMVGVENIRGSTRFTFGISSLSAGFELLPVLIGVFAITEILMELEQKERETKIQHKISEVFLTREEFKSLVIPILVGAVIGIIIGVIPGTGGTIATFLAYNVLRNISKNKEKFGKGAIEGVAVVECANNAVTGGALVPTLALGVPGDVVTAVMLGAMILIGVRPGPLLFQATPDLVYSFFAGWFIIQFMMLITGFVSTLTAPYILEIPKKILMPIILVFAIIGSFAIRNSLYDVAIALIFGLIGYFMRKHNFPATPLILGVILGPMAEQNLNRALILSGNDYTVMFKSPISLTLLVLAILSIVLGVISGRRESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ27</accession>
    <name>B8DZ27_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582738.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352267.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0339"/>
    <dbReference type="EnsemblBacteria" id="ACK41653">
        <property type="protein sequence ID" value="ACK41653"/>
        <property type="gene ID" value="Dtur_0339"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0339"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.359"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100275_2_1_0"/>
    <dbReference type="InParanoid" id="B8DZ27"/>
    <dbReference type="OMA" id="PVEYYLA"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="145" mass="16103" checksum="2BA5A88D17FA5D15" modified="2009-03-03" version="1">MANLVTFKAKGEWKGNLKVEVNIRNKFTINMDEPPSLGGEDTAPNPVEVVLAALIGCLGIVIPVVAREKNIPLESIEIETEGDLDPRGFMGDPSVRAGYQEVRAKVKIISPVERERIEELMKEVERRCPVSDIIRNPVNLKISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ59</accession>
    <name>B8DZ59_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352299.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0381"/>
    <dbReference type="EnsemblBacteria" id="ACK41685">
        <property type="protein sequence ID" value="ACK41685"/>
        <property type="gene ID" value="Dtur_0381"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0381"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_0"/>
    <dbReference type="InParanoid" id="B8DZ59"/>
    <dbReference type="OMA" id="NQFLAGR"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="421" mass="47547" checksum="E98C2561FD45AB25" modified="2009-03-03" version="1">MKKLLSLLVVSLLVLLMMASGQKTVTIRYGVWMSEQLDGIKAQISTFEKRYPNIKVKLEHVPWEDYWTKLQTMMAGGDCWDVFTMDTGFYLPDYVARNALVDITPFIKKDNLDLSVYPSGVLKLHNFEGKYYSLPRDYDTIGMFYNKKAFDEAKLKYPDGNWTWEDLKKAVEKLTKKDAKGNIVRYGITVDGGPLSVSQAFLFPMILSLGGDLVKDGKVVFDSPQVKEALSFARELTEKGYAPKPGVTSGDLFIAGKSAINFSGSWMLGYYAENIKSFNFGVVMIPKSRTGKRANISDSLGNVIWSKTKNLDAAWTFVKWMASKEAAEILGKSGTVIPAYRGTDTLWMQSFKRFGKEKDAKVFIDSVKYTNPWPQTRGSSEWFDRWETYYIVEIIAGRLGVEEGLKQATEEINGIIEKASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ84</accession>
    <name>B8DZ84_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkaline phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582902.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352431.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0524"/>
    <dbReference type="EnsemblBacteria" id="ACK41817">
        <property type="protein sequence ID" value="ACK41817"/>
        <property type="gene ID" value="Dtur_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0524"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.557"/>
    <dbReference type="eggNOG" id="COG1785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008539_5_0_0"/>
    <dbReference type="InParanoid" id="B8DZ84"/>
    <dbReference type="OMA" id="NIYAYAN"/>
    <dbReference type="OrthoDB" id="585847at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11596">
        <property type="entry name" value="PTHR11596"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="537" mass="60205" checksum="EE8EAFE7140DA4AE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ98</accession>
    <name>B8DZ98_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Iron (Metal) dependent repressor, DtxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0541</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DtxR/MntR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582916.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352445.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0541"/>
    <dbReference type="EnsemblBacteria" id="ACK41831">
        <property type="protein sequence ID" value="ACK41831"/>
        <property type="gene ID" value="Dtur_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0541"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZ98"/>
    <dbReference type="OMA" id="VYRRYII"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022687">
        <property type="entry name" value="HTH_DTXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01325">
        <property type="entry name" value="Fe_dep_repress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50944">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH dtxR-type" evidence="8">
        <location>
            <begin position="5"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="207" mass="23708" checksum="00F394E302D09235" modified="2009-03-03" version="1">MNLFLTESLEDYILSIYELQSRIVRIKDIARLKKVKLPSVVNAIKILSDMGLVEHEKYGYVTLTDYGIEVAQELYRRRKLLFRFFTEILGVDENTALQDSHRIEHDLSPKSLEKLTEFTERFIKSRKEEKDMPLTLKDLKVGEEGKIVELRGGGGIISRLLSMGAVPGTIVKVEKIAPLGDPIEILILGYHLSLRKEEAEKILVERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZA0</accession>
    <name>B8DZA0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0543</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582918.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352447.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0543"/>
    <dbReference type="EnsemblBacteria" id="ACK41833">
        <property type="protein sequence ID" value="ACK41833"/>
        <property type="gene ID" value="Dtur_0543"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0543"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.579"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_3_0_0"/>
    <dbReference type="InParanoid" id="B8DZA0"/>
    <dbReference type="OMA" id="PLGYDWK"/>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0410">Iron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="569"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="669" mass="74753" checksum="895E11B48C777961" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZA3</accession>
    <name>B8DZA3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0546</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582921.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352450.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0546"/>
    <dbReference type="EnsemblBacteria" id="ACK41836">
        <property type="protein sequence ID" value="ACK41836"/>
        <property type="gene ID" value="Dtur_0546"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0546"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.582"/>
    <dbReference type="eggNOG" id="COG2445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZA3"/>
    <dbReference type="OMA" id="KFRNRIV"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="151" mass="17720" checksum="C25DA741C7E22D83" modified="2009-03-03" version="1">MIIPLNKEVILSRIREIEKGKEKLLRFKDYSLEEFKSGENFAIAEHYLRRALEAVFDIGNHILSRIPGIRVSTYKDIALKLGEYGIIPGKFAKEVLVKMAGYRNRLVHFYAEVSIEELYYIIQNNLNDFDEYLKYIKDLLENPEKFGLTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZA9</accession>
    <name>B8DZA9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582927.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352456.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0552"/>
    <dbReference type="EnsemblBacteria" id="ACK41842">
        <property type="protein sequence ID" value="ACK41842"/>
        <property type="gene ID" value="Dtur_0552"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0552"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.588"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZA9"/>
    <dbReference type="OMA" id="MLYADYV"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="109"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="221"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="454" mass="50887" checksum="781B24D2D0CF4BAA" modified="2009-03-03" version="1">MFDVLRGIISKVPADYVDIRYEKMSETKIVLNNREIFQLGTNTGDGFVVRVLKNGGFSSIAFTKVEDVEKAIKICLENAELISKNSKKKVKLAEVEVIKDTFIPSLREDPRKVSIDEKLELLMHYNEIPLKFENITTNMQYTEVIREKYFVSSEGTEIREDLITTGIRGMIISRDGSLVQNVRVGIGGSDGFYRLRNREEEFEKKTKIVLDLLKAEPVKGGVYNVILNPDMTGVFTHEAFGHFSEADLIEDNLSMREKMKIGAKLGSDILTIIDDPTIPNQLGFYKYDDEGVRARRTYLLKDGVLSGRLHSRRTAAEFGEPITGHCVAEDYRYAPIVRMGNIFIEPKDKSFEELLDLLGDGLYILDAKGGQTSGENFTFGAQYAFEVKNGKIVKMLRDINISGNLYKTLMDIVAIGRDFELSEVGGCGKGQLNIRSCHGGPHILVKNVVIGGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZD4</accession>
    <name>B8DZD4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-grasp enzyme-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582952.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352481.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0579"/>
    <dbReference type="EnsemblBacteria" id="ACK41867">
        <property type="protein sequence ID" value="ACK41867"/>
        <property type="gene ID" value="Dtur_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0579"/>
    <dbReference type="eggNOG" id="COG3919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_691914_0_0_0"/>
    <dbReference type="OMA" id="KGNYYKA"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018169">
        <property type="term" value="F:ribosomal S6-glutamic acid ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018410">
        <property type="term" value="P:C-terminal protein amino acid modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003806">
        <property type="entry name" value="ATP-grasp_PylC-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02655">
        <property type="entry name" value="ATP-grasp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="104"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="339" mass="39070" checksum="931D664D7F1CA742" modified="2009-03-03" version="1">MFRVLVTSGSYKHSIAIQKYLKISIPDIYLIVQDDSKLNFSRLYGYANVIKRCSLEEALLANDFDMVIPVGAKDILPTLKYVREKAILPSEESIRVCFNKYQTIQLAKTCGVPVPFSIHLKSLKEIEKVKGIVKFPCVIKPSSELEAKFVFYANNQKELNYYLNQSFKILGENSQHGVILQEYISGMGVGFFALYKKGNPVRIFMHQRLREWPISGGASTAAKAFYSDKLKNYGLTLLNTLNWNGVAMVEFKYKYDEEEFYLIEVNHKFWGSLELALRAGVNFPADLVRIFRGESLSYSENYNINQHFYWPLDGDILNLVKTKRLYLIREYFNPNVSTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZD6</accession>
    <name>B8DZD6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582954.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352483.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0581"/>
    <dbReference type="EnsemblBacteria" id="ACK41869">
        <property type="protein sequence ID" value="ACK41869"/>
        <property type="gene ID" value="Dtur_0581"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0581"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.616"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046673_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZD6"/>
    <dbReference type="OMA" id="RYEEYLP"/>
    <dbReference type="OrthoDB" id="842576at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="470" mass="55374" checksum="E828C668E2054867" modified="2009-03-03" version="1">MSTLIVSIPENFYLQEFNYIIKVLLIDFLGLDYTLEMYDGDKVKIRLKGDESDKALSIENILFNTPTEEWLKESSLPLSPLPRWNILDDLPEVRLCKKDLPIIYGRLLSNGRYFDQGKNFIHLGVDIFGSCFFMLTRYEEIIVSERDEHERFPAKASLAYREGFLSRPIVNEYVEILWALLKRLWPGLERKQHSYKVLLTHDVDHPFVVYDQSWYQILRNVSADLINRKNISLSFQRIKCKVKNDPKLDPANTFDFIMDLSEKNGLQSEFYFITDHPAGTLDGSDYSLESPYIQVLIDRIYKRGHRIGLHASYNSYCDSQQIKREFEKLIMLAEKLSIKQDSYGGRQHYLRWKNPTTWQNWEDTGLNYDSTLSFADYAGFRTGVCYEYPVYNLVTRKSLNLFEKPLIVMDVTLFGSSYMNLKVEESFRYVEHLSKCCRLFGGTFVLLWHNTSLIEKWQKNIYRDVLYNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZE8</accession>
    <name>B8DZE8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein, N-terminal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41881">
        <property type="protein sequence ID" value="ACK41881"/>
        <property type="gene ID" value="Dtur_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0593"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129890_2_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="86" mass="9987" checksum="FED0E4016561EFE7" modified="2009-03-03" version="1">MLAEVIDIAEKKRISIDYEELIDKIEENSSFEIYPLDINVLRMLKDVPNIYELHDKIIVATAKLLDAKVITKDVDIQNSKLVETIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZF7</accession>
    <name>B8DZF7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582975.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352504.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0602"/>
    <dbReference type="EnsemblBacteria" id="ACK41890">
        <property type="protein sequence ID" value="ACK41890"/>
        <property type="gene ID" value="Dtur_0602"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0602"/>
    <dbReference type="HOGENOM" id="CLU_962192_0_0_0"/>
    <dbReference type="OMA" id="YNPISYI"/>
    <dbReference type="OrthoDB" id="620166at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867706" evidence="1">
        <location>
            <begin position="21"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="289" mass="31954" checksum="2E227E181959BCAC" modified="2009-03-03" version="1">MKKILISFLTITFLISLTFASDTGGVFSPLILDAKSGGMGEAFTAISEGFSGLTYNPAGLTYIDEVTLGFTHLQIPQSFTRVEFIGGAINLGIFSLGAGLQAVGVTNPDELLFPYYEGIAQISLAKKLNNKLSLGTSLRLYVAKLDTEEANGLGIDIGAIYEITPVLRLGAVWYNPISYIKWTTGLIETPGRQDLVLGVNYKLFLGEFPLNIAFDFSFYDKIYFYQRLHFGLETQIPKTPVIIRTGYNGEKNTLSFGVGLNTKNIEFNYAFLYTKDMSNQHIFSLSLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZF9</accession>
    <name>B8DZF9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582977.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352506.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0604"/>
    <dbReference type="EnsemblBacteria" id="ACK41892">
        <property type="protein sequence ID" value="ACK41892"/>
        <property type="gene ID" value="Dtur_0604"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0604"/>
    <dbReference type="HOGENOM" id="CLU_1394404_0_0_0"/>
    <dbReference type="OMA" id="PVVENRS"/>
    <dbReference type="OrthoDB" id="2128192at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="195" mass="22723" checksum="76821321283FFF52" modified="2009-03-03" version="1">MDILKYFLILLLILILFQVTFANMVPVVENRSKVIARVRAVFLKDFPFSEIVLEILKSENVEGFKNFAEVGDIILVYPISLKPNISSAGDFERRILYTCYFLKPGDMVRAEIEFIGDEVMRGWVVRDVERIVEVREDLLKDVIYSFLKAKGVIKEGERLEYKVVKDGKFYKVKAKVEEKEINIILDENLVILNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZG1</accession>
    <name>B8DZG1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, TM1812 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582979.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352508.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0606"/>
    <dbReference type="EnsemblBacteria" id="ACK41894">
        <property type="protein sequence ID" value="ACK41894"/>
        <property type="gene ID" value="Dtur_0606"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0606"/>
    <dbReference type="eggNOG" id="ENOG502ZANU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025124_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZG1"/>
    <dbReference type="OMA" id="TYFKLEM"/>
    <dbReference type="OrthoDB" id="1137060at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013383">
        <property type="entry name" value="CRISPR-assoc_prot_DxTHG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011742">
        <property type="entry name" value="CRISPR-assoc_prot_TM1812"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019016">
        <property type="entry name" value="Csx1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09455">
        <property type="entry name" value="Cas_DxTHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02221">
        <property type="entry name" value="cas_TM1812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02549">
        <property type="entry name" value="CRISPR_DxTHG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="396" mass="47282" checksum="E01A65EEE453DA38" modified="2009-03-03" version="1">MKNILISLIGKGRTSENILKGYVKTKYRFRTGEIFETGFFGSALWKYVSHKEKIDHWYIFGTTKSSWSEIIYALEESKRNNFYHLSYEVYEAEITGIAENLLKTWEDALSSEIPGIKLILIDPFNYEFFSEFLLKNLPDEDLKIILDITHGYRYLPLILSFSLMYVKNFKSIKELKIYYGALEMSENNEAPVLEIDHINELFQISTAFELYRNSGYFSELLKNLGIHGKENLYFMIEMNLRPRKELKEVIESLKKVEKEYKKICAESLIKDLTPLYSEEYLEDRMTKRAEFFFEKKQYLKSLILLYEALTIIILKKAGYRDLTKIENRRQKVKEVYIKVLPEDWMREIFDNFERVRNSSVHGNIRETQSIIRNFEDFNDLFKESLKLFYHIRKTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZG7</accession>
    <name>B8DZG7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A)</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic oligoadenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_0612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated Cas10/Csm1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582985.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352514.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0612"/>
    <dbReference type="EnsemblBacteria" id="ACK41900">
        <property type="protein sequence ID" value="ACK41900"/>
        <property type="gene ID" value="Dtur_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0612"/>
    <dbReference type="eggNOG" id="COG1353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017487_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZG7"/>
    <dbReference type="OMA" id="PSAFYYS"/>
    <dbReference type="OrthoDB" id="423797at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09680">
        <property type="entry name" value="Cas10_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013408">
        <property type="entry name" value="Cas10/Csm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041062">
        <property type="entry name" value="Csm1_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18211">
        <property type="entry name" value="Csm1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02578">
        <property type="entry name" value="cas_TM1811_Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="11">
        <location>
            <begin position="527"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK41900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="799" mass="93363" checksum="AAE8EC8B3A806F2A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZH6</accession>
    <name>B8DZH6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CRISPR-associated helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_0621</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582994.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352523.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0621"/>
    <dbReference type="EnsemblBacteria" id="ACK41909">
        <property type="protein sequence ID" value="ACK41909"/>
        <property type="gene ID" value="Dtur_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0621"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.658"/>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010123_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZH6"/>
    <dbReference type="OMA" id="EGWNSEI"/>
    <dbReference type="OrthoDB" id="1149839at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="11">
        <location>
            <begin position="8"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="268"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="484"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK41909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="784" mass="92533" checksum="D91273D67B955AB3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZK3</accession>
    <name>B8DZK3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583021.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352550.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0651"/>
    <dbReference type="EnsemblBacteria" id="ACK41936">
        <property type="protein sequence ID" value="ACK41936"/>
        <property type="gene ID" value="Dtur_0651"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0651"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034180_11_2_0"/>
    <dbReference type="InParanoid" id="B8DZK3"/>
    <dbReference type="OMA" id="VQVWHVY"/>
    <dbReference type="OrthoDB" id="498436at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010290">
        <property type="entry name" value="TM_effector"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05977">
        <property type="entry name" value="MFS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="216"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="413" mass="45625" checksum="2A1F5F234F302639" modified="2009-03-03" version="1">MRKNLFRALKSRNYKLYFSGQAISLIGSWIQSTAMSWLVYRLTNSSVLLGTTAFLSQIPNLFFSPFVGVFLDRFSKHKILILTQTLLMFQAFTLSLLTLTNTIRIWHLLLLSLILGILNSVDAPTRQSFVIEMVENPEDLSNAIALNSLLFNIARLIGPTISGFLIALLGEGMCFLINALSFLAVIIALLFMRIKSQILVVSENIIKDLKAGFNYAFKFIVVKYILIFISLSSLFASIYSVLMPIFAKDILRGGPETLGILTGAIGGGALIGAIYLAGRSKVKGIESIISYSFGTAGIGLILFSLSKNLYFSLFALFITGLSFMLNSVCSNTLIQSIIDNHVRGRVMSIYVMFFMGSMPIGSYIGGLFAKHIGAVSTVLLSGILCIICSFIYRIRLPLLRKHIYSIFDKKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZL3</accession>
    <name>B8DZL3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phage shock protein C, PspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583031.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352560.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0661"/>
    <dbReference type="EnsemblBacteria" id="ACK41946">
        <property type="protein sequence ID" value="ACK41946"/>
        <property type="gene ID" value="Dtur_0661"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0661"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.699"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099432_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZL3"/>
    <dbReference type="OMA" id="WIVVPEN"/>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="119" mass="13528" checksum="25135F6B7E513EB4" modified="2009-03-03" version="1">MEKKLYKSKKDRIFLGVCGGIGEYLGIDPVLIRLIFIFSILFLGPLSVLLYIICALVIPEEPEYSEPRSYRSDGELLGWLFLAIGVYFLGRTFGIFHVSFGLMLALLFIFLGILLLFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZN9</accession>
    <name>B8DZN9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583057.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352586.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0687"/>
    <dbReference type="EnsemblBacteria" id="ACK41972">
        <property type="protein sequence ID" value="ACK41972"/>
        <property type="gene ID" value="Dtur_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0687"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077420_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZN9"/>
    <dbReference type="OMA" id="VICGHEH"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="288" mass="34010" checksum="338D3710E7F8A75F" modified="2009-03-03" version="1">MKIFAISDLHIDYLRIRRGLKIFEERELLKDFLKELTSKDVDVFVFAGDISAKLWEVELFLEVFRKFSGLKIFVPGNHDIWREGEITSDQKYYKILPELCKGYDFIYLPFKPLEFSNLAIIGTMGWYDYSLGDSYYSKRDFERGEYKGIRWRETYWKLVNFYNHEKVLRNEEICELIYEEFQNSLLKVEKSIEKIVITHFIPFEEILPIKNFFSAYLGSKKFGDVIVANNVGKVICGHEHKSGVFYVSNITVYKPAIGYADSIESLISKYRQNSILIEILDNHRLSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZR4</accession>
    <name>B8DZR4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583082.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352611.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0712"/>
    <dbReference type="EnsemblBacteria" id="ACK41997">
        <property type="protein sequence ID" value="ACK41997"/>
        <property type="gene ID" value="Dtur_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0712"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.749"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_17_0_0"/>
    <dbReference type="InParanoid" id="B8DZR4"/>
    <dbReference type="OMA" id="WAHDWIG"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901982">
        <property type="term" value="F:maltose binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042956">
        <property type="term" value="P:maltodextrin transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015768">
        <property type="term" value="P:maltose transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006060">
        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870995" evidence="4">
        <location>
            <begin position="21"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="397" mass="43424" checksum="BE043B0314131B5C" modified="2009-03-03" version="1">MKKVLILVLLLMMVFSLSKAAVPGKITIWTSEAQVKGLREFVKNFSTKYGIPVEVSEVSFSDIKPKFITSAPTGEGPDIIVGAHDWIGELAVNGLLLPIDFLPKSILDQFTPVTLQAMSYGGKLYGIPYSMEAVALIYNKNLVPNPPTTYESLVRTAKNLTKGGIYGFLYDYNNFYFSFPFFSALGGYVFKETPNGLDPLDIGLANEGAIKGVEKLVNLFKEGILKQGVDYQTTTSLFSEGKLGMMINGPWEIDNIKKANINYGVAKLPKIDGKPMRPFVGVQGFMINSRSPNIAILKTFALEVLATKELELKLFETDPRILARKDAYKVVSSNPDIKAFGASAADGIPMPNIPEMGPVWSYMGDTLTLITSGKKAPDVALKEAVAQIKDAILKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZT6</accession>
    <name>B8DZT6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583104.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352633.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0737"/>
    <dbReference type="EnsemblBacteria" id="ACK42019">
        <property type="protein sequence ID" value="ACK42019"/>
        <property type="gene ID" value="Dtur_0737"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0737"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.775"/>
    <dbReference type="eggNOG" id="COG3877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132137_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZT6"/>
    <dbReference type="OMA" id="YPTAKAR"/>
    <dbReference type="OrthoDB" id="1943427at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018658">
        <property type="entry name" value="DUF2089"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09862">
        <property type="entry name" value="DUF2089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="125" mass="14503" checksum="E695F6262D447F72" modified="2009-03-03" version="1">MPHPLPRCPICGNEMVIKKLECPNCKITIEGEFWVNRLASLPQEELEFLELFLKTRGNVKEMERILKLSYPTVRSKLDSILKKLGLLSEEEEEPKDKVKWIINKLERGEITVQDALKILEEGEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZT9</accession>
    <name>B8DZT9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583107.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352636.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0740"/>
    <dbReference type="EnsemblBacteria" id="ACK42022">
        <property type="protein sequence ID" value="ACK42022"/>
        <property type="gene ID" value="Dtur_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0740"/>
    <dbReference type="eggNOG" id="ENOG5032KU4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865168_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZT9"/>
    <dbReference type="OMA" id="GVRHMRY"/>
    <dbReference type="OrthoDB" id="1842762at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004629">
        <property type="term" value="F:phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11009">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001531">
        <property type="entry name" value="Zn_PLipaseC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="316" mass="36872" checksum="70EDC6594F76F9C7" modified="2009-03-03" version="1">MRKRIIFLGILLLVLISPIFSWSAHREMTELILKDYPWLGKYNKIKVTPYTYNDPSPYNPAYAIPYRGEKIGDTIDAITIITRYVIEPDNGMDDNINLNSMQKLTGGSSGWRHQYYIALGGALKLGEAPKRIIHFWNLAKEAFQKKDYYWGFRFFAYSLHYLQDLTQPFHAYPMPLGNVIKNIFNLDKVIAQGENHHYTLEDYQEYQILNQNPLYIDTLKKAKPYKIENPEEAGIKAAWTARNDAGKLFEIQSKYFPGINNTKNYKAPKELFKGNNSTLKEEYDKIILRNLENFAGYTKGYLEFLKEFLEKIEDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZU8</accession>
    <name>B8DZU8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="16" type="ordered locus">Dtur_0749</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583116.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352645.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0749"/>
    <dbReference type="EnsemblBacteria" id="ACK42031">
        <property type="protein sequence ID" value="ACK42031"/>
        <property type="gene ID" value="Dtur_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0749"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.787"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_2_1_0"/>
    <dbReference type="InParanoid" id="B8DZU8"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="96"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="156"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="364"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="388"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="250"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="301"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACK42031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="493" mass="53952" checksum="9C1814FBA81125BE" modified="2009-03-03" version="1">MNFDERFLGEALTFDDILLVPAYSEVTPREVSVDTYLTDRIHLNIPILSAAMDTVTEARMAIAIAREGGLGIIHRNMSIERQAEEVDKVKRSEHGMITDPIFLYPDQTVGEALSIMAKYHISGLPVVERDGKLVGIVTNRDLRFESDMNKKVSEIMTKDNLIVAQVGITIKDAQEILQRYKIEKLPIVDKDFKLKGLITIKDIQKMRQYPNAAKDKKGRLLAGAAIGVGDEAIRRAKALVEAEVDVIVIDTAHGHHKKVLETVKELKKLFSKEVVIVAGNVATAEGTKALIDAGADVVKVGIGPGSICTTRVVAGIGVPQFSAIWECAKEAQKHNVPIIADGGIKFSGDITKAIAAGAHAVMLGSLLAGTEESPGEIEIYQGRSFKVYRGMGSLSAMKEGSKDRYFQENSEKLVPEGIEGRVPYRGPVSEVLFQLVGGLKSGMGYCGVKNLEELRTKTKFIKITNAGLRESHPHDIIITREAPNYSISTWENH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZV1</accession>
    <name>B8DZV1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_0752</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583119.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352648.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0752"/>
    <dbReference type="EnsemblBacteria" id="ACK42034">
        <property type="protein sequence ID" value="ACK42034"/>
        <property type="gene ID" value="Dtur_0752"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0752"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.790"/>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZV1"/>
    <dbReference type="OMA" id="DMIMLKD"/>
    <dbReference type="OrthoDB" id="1718114at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="112"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="279" mass="31406" checksum="64FCC385527EDCE0" modified="2009-03-03" version="1">MRLIPYLHLRKIVEEALKEDIGFGDITTESTIPEDMISRAVIIAKEEGILAGLPVAEEVFKLLDSKIEFKEFKKDGDEIKKGDVILEIKGKTKTILMGERTALNFLQRLSGIATYTKKCVDVVKPYGVKILDTRKTTPTLRIFEKYAVKIGGGENHRFGLYDMVLIKDNHIRAVGSIKEAIERVRERVSHVYKIEVEVTNLEELKEALESKADIVLLDNMDYDTLKEAVSIAKGKVMIEVSGNISLEDLEKIARLGVNFISIGKLTHSYKSLDLSLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZW6</accession>
    <name>B8DZW6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583134.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352663.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0767"/>
    <dbReference type="EnsemblBacteria" id="ACK42049">
        <property type="protein sequence ID" value="ACK42049"/>
        <property type="gene ID" value="Dtur_0767"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0767"/>
    <dbReference type="HOGENOM" id="CLU_1701456_0_0_0"/>
    <dbReference type="OMA" id="RIKNAYM"/>
    <dbReference type="OrthoDB" id="2140053at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="154" mass="17990" checksum="F042ED5AE50473E2" modified="2009-03-03" version="1">MQSLVISRLRILTFLFMTIYLLTNAFFDDFRILILMIFAILYSSVMYYFSAREKVKESFVLSLIDLFVILLYLFLIDAIAVKFLFLIYLPTIKEILYRRIKNAYMISFLGNLGVIILSFILKESLPLKITTSLIPISFLLPYLSSSYLKEMEGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZX0</accession>
    <name>NFI_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease V</fullName>
            <ecNumber evidence="1">3.1.21.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deoxyinosine 3'endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deoxyribonuclease V</fullName>
            <shortName evidence="1">DNase V</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nfi</name>
        <name type="ordered locus">Dtur_0771</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endonuclease V family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583138.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352667.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZX0"/>
    <dbReference type="SMR" id="B8DZX0"/>
    <dbReference type="STRING" id="515635.Dtur_0771"/>
    <dbReference type="EnsemblBacteria" id="ACK42053">
        <property type="protein sequence ID" value="ACK42053"/>
        <property type="gene ID" value="Dtur_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0771"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.808"/>
    <dbReference type="eggNOG" id="COG1515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047631_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZX0"/>
    <dbReference type="OMA" id="RIHFRQA"/>
    <dbReference type="OrthoDB" id="1681607at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016891">
        <property type="term" value="F:endoribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00801">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000133869" description="Endonuclease V">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with target DNA" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00801"/>
        </source>
    </evidence>
    <sequence length="228" mass="25954" checksum="ECF60F5AF5E0DF19" modified="2009-03-03" version="1">MDWGREFFKWRGYEETVKLQEELSKKIILEDKFKELRYIGGVDTSSLGEKIVGIITILVFKTLELVEISVALSEVNFPYIPGFLSFREGPVILRAWEKLKIKPDLLIFDGQGIAHPRRLGIASHIGYVLDVPSIGCAKNILVGFYKEPDKRKGSFEYIYHKGEIVGAAVRTKDNVKPVFVSLGHKISLNTSIDIILKTSTKYRIPEPVRLAHLYSKRMLNSEIEGEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZX7</accession>
    <name>B8DZX7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminopimelate epimerase</fullName>
            <shortName evidence="3">DAP epimerase</shortName>
            <ecNumber evidence="3">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dapF</name>
        <name evidence="4" type="ordered locus">Dtur_0778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583145.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352674.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0778"/>
    <dbReference type="EnsemblBacteria" id="ACK42060">
        <property type="protein sequence ID" value="ACK42060"/>
        <property type="gene ID" value="Dtur_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0778"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.815"/>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053306_3_0_0"/>
    <dbReference type="InParanoid" id="B8DZX7"/>
    <dbReference type="OMA" id="HVAMRVH"/>
    <dbReference type="OrthoDB" id="1921631at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="212"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="222"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="285" mass="32119" checksum="6ABB9D0B3CE1B869" modified="2009-03-03" version="1">MEFIKSHGLGNDYIVFDKEKINFPLTEKNVRLICDRNYGIGSDGILILEKINNQEFKVRIFNPDGSEAEKSGNGIRILAKYIYDYRYTTEKEFYIYTLGGKVKVSIVEEQKGRAKSIEVEMGKITFKSSEIPVLGSEREIIDEELKINDETIKVTCLSIGNPHCVFFVDEINEEKIKSLGPKIENHPMFPNRINVQMVKVLSPDKIEIRIWERGAGYTLASGSSSCAAASASYKKGLVNNQVEVIMPGGVLHVKINPDWSVNLVGPAEEVFKGELSQEFLFKLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0A1</accession>
    <name>B8E0A1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353160.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1268"/>
    <dbReference type="EnsemblBacteria" id="ACK42546">
        <property type="protein sequence ID" value="ACK42546"/>
        <property type="gene ID" value="Dtur_1268"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1268"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1308"/>
    <dbReference type="eggNOG" id="COG1379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060249_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0A1"/>
    <dbReference type="OMA" id="HAFTPWT"/>
    <dbReference type="OrthoDB" id="731823at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="414" mass="47511" checksum="DF7486A1F4BC2A99" modified="2009-03-03" version="1">MRIKEVISLRFIADFHIHSKYSRATSKDMNLEGISKWAKIKGVALLGTGDFTHPLWFEELEEKLKEENYGIYSYNSTNFILTSEVSLVYSQNKKLRRIHLIIFSPTLEIASKINKTLSKFCDLSVDGRPTIGKSILEILPLLWEISEDVHIIPAHAWTPWFSLFGSNSGFDSIEEAFDRYSSKIFALETGLSSDPPMNWRLSSLDKICLISNSDAHSPGKIGREANVFNCDMNYREIFNAIKTQDKNKFLFTIEFFPEEGKYHYDGHRNCNVSLHPKESQRLENLCPVCKKPLTIGVLHRVEALADREEGFIPQNKIPYVNLVPLEEIIAQAMDKDVSSPYVQREYMRFIENLGDELSILLYRDISEIAKVSEKVAIGIRLMREGKISIKPGYDGVYGKIEIFGNEDKRQISFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0F5</accession>
    <name>B8E0F5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_1326</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353214.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1326"/>
    <dbReference type="EnsemblBacteria" id="ACK42600">
        <property type="protein sequence ID" value="ACK42600"/>
        <property type="gene ID" value="Dtur_1326"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1326"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1371"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_0"/>
    <dbReference type="InParanoid" id="B8E0F5"/>
    <dbReference type="OMA" id="TIGRQHP"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="202"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="267"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="307"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="425" mass="48192" checksum="5A68FBE73A48543B" modified="2009-03-03" version="1">MEYLSLLILLIISGFLSALETSLLSLPKIRLHHLAENGDKRAIKIVRLMENSQRVLSTILIANNFVNVLISAIATKIALATFKNFGVAVATGVSTFFIVVFGEVIPKSFGLKLKEKYALAVINVFYPFYIIFIPITKLILGFSNIFYKFVGKTQENISPFATVDEFLTLVNVGEKEGIIEKEEKELINNVLEFTDTEVHEIMVPRIDMVCVSVDSPLKEVWRKIIEEGHSRIPVYEGSIDNIVGIVHAKDVLKALAEKDPNIKVRDILRDVIYVPENMKINELFNEMRKKKAHLAIVVDEYGGTAGLVTLEDVLEELVGEIEDEYDKEENKFNFIDENTLVVDAKINIYELNDILEEAWGMTLPKTEYDTLGGLILDLLNRVPSRGEQIDLGNLIIVIDSVRRQRIEKVKIIRKIKKEGEEEKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0G1</accession>
    <name>B8E0G1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="6">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583687.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353220.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1332"/>
    <dbReference type="EnsemblBacteria" id="ACK42606">
        <property type="protein sequence ID" value="ACK42606"/>
        <property type="gene ID" value="Dtur_1332"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1332"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_3_0_0"/>
    <dbReference type="InParanoid" id="B8E0G1"/>
    <dbReference type="OMA" id="IGPEGCF"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="246" mass="28472" checksum="CF466940E4C7FA9D" modified="2009-03-03" version="1">MSPMFFATTFKEPDLLYIEDKEDIFHMVNVLRIREGEKIDVNYNSKIFRAYVEKIEEDRVICKIIEKIGNKEANVEVYLCQSLPKKESWEIILEKCTEIGVVGFIPLQTQRSIVNLSRDELNKKYQRWNKVIKEAVKQCGRNKLPLLYKVQTLEESLNLAKKENADILIAWEGAELSLKNIIRNNIRDKIFLFIGPEGSFTDEEINLMKKYNGIFFNMGPRILKVETAAIVASALLLYEKGGLGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0J1</accession>
    <name>B8E0J1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583716.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353250.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1362"/>
    <dbReference type="EnsemblBacteria" id="ACK42636">
        <property type="protein sequence ID" value="ACK42636"/>
        <property type="gene ID" value="Dtur_1362"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1362"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1407"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_6_2_0"/>
    <dbReference type="InParanoid" id="B8E0J1"/>
    <dbReference type="OMA" id="RFRDSNH"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051096">
        <property type="term" value="P:positive regulation of helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="146" mass="16738" checksum="B5FD67D6B9647752" modified="2009-03-03" version="1">MLNKVLLIGHLVRDPEMRYTPSGIPVTTFRIAVNRPKNSKGESTADFIDIVAWRRLAEICGDYLKKGRLVAVEGRLRTRTYQTPDGQRRRVVEVEAINVHFLGKKSENTESISIEEPSEEILDIDIENEEEILNEILEESEEESNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Q7</accession>
    <name>B8E0Q7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584151.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353691.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1806"/>
    <dbReference type="EnsemblBacteria" id="ACK43077">
        <property type="protein sequence ID" value="ACK43077"/>
        <property type="gene ID" value="Dtur_1806"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1806"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1858"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="InParanoid" id="B8E0Q7"/>
    <dbReference type="OMA" id="FQRNIMS"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="280" mass="31509" checksum="A6D3F249F0EEF73C" modified="2009-03-03" version="1">MKLSRVLIYLVLILFAIFYLTPVYVLLITSMKSFAEVDLKRMWNPPKTISFESFVKAWLGDSKKGLRGLSQNFLNSLYLVIPATIISALLGSMNGYVLTKWKFQGANIIFPLLLFGMFIPYQSILIPLVQVLQRMKLYSTIYGLIFVHVVYGIPITTLIFRNYYSTIPTELIEAAKIDGADFLGIYRRIVLPVSMPAFAVVMIWQFTSIWNDFLFGLVVAPNPSVQPVTVALNNLAGSYFVEWNIQMAGALITALPPLLVYIFLGKYFMRGLLSGSLSGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0T7</accession>
    <name>MINC_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable septum site-determining protein MinC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">minC</name>
        <name type="ordered locus">Dtur_1400</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with MinD and FtsZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MinC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583752.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353288.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0T7"/>
    <dbReference type="SMR" id="B8E0T7"/>
    <dbReference type="STRING" id="515635.Dtur_1400"/>
    <dbReference type="EnsemblBacteria" id="ACK42674">
        <property type="protein sequence ID" value="ACK42674"/>
        <property type="gene ID" value="Dtur_1400"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1400"/>
    <dbReference type="eggNOG" id="COG0850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048711_2_0_0"/>
    <dbReference type="InParanoid" id="B8E0T7"/>
    <dbReference type="OMA" id="EMECAYI"/>
    <dbReference type="OrthoDB" id="1665744at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901891">
        <property type="term" value="P:regulation of cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00267">
        <property type="entry name" value="MinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013033">
        <property type="entry name" value="MinC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036145">
        <property type="entry name" value="MinC_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005526">
        <property type="entry name" value="Septum_form_inhib_MinC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34108">
        <property type="entry name" value="PTHR34108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03775">
        <property type="entry name" value="MinC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63848">
        <property type="entry name" value="SSF63848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_1000191242" description="Probable septum site-determining protein MinC">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00267"/>
        </source>
    </evidence>
    <sequence length="202" mass="23016" checksum="4694E8B1C6F5258F" modified="2009-03-03" version="1">MSKISFKGDLKEGIKIIIDPNLNWDEIRNLIVDEIKSKEGFLKGSSIYVDFQGKDIKDEDWQEFRKEIYEKYGIMLSKELYRLRISNSNNAKIVLGPIRSGKSLNVKDNLLVIGDVNSGSEIICNKNVFVLGKVRGSIWAGYENNDKATIFALELEPEKIQIARYILDLSKIKKEKTGVGYWVYVENGEVKLNRYSGGKKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0U4</accession>
    <name>B8E0U4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyl transferase, WecB/TagA/CpsF family</fullName>
            <ecNumber evidence="1">2.4.1.187</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.187" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583759.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353295.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1407"/>
    <dbReference type="CAZy" id="GT26">
        <property type="family name" value="Glycosyltransferase Family 26"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42681">
        <property type="protein sequence ID" value="ACK42681"/>
        <property type="gene ID" value="Dtur_1407"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1407"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1454"/>
    <dbReference type="eggNOG" id="COG1922">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063203_3_1_0"/>
    <dbReference type="InParanoid" id="B8E0U4"/>
    <dbReference type="OMA" id="PWRWRRM"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047244">
        <property type="term" value="F:N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06533">
        <property type="entry name" value="Glyco_transf_WecG_TagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004629">
        <property type="entry name" value="WecG_TagA_CpsF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34136">
        <property type="entry name" value="PTHR34136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03808">
        <property type="entry name" value="Glyco_tran_WecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00696">
        <property type="entry name" value="wecG_tagA_cpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="246" mass="28810" checksum="BE21A6A41CE92AC3" modified="2009-03-03" version="1">MQIIKIFGIKFSSYDNMNEFRNHIKNFLSTDNCKSIFTPNAEMIARTVEDKSFREVLKRSEVNLPDGVGILLLAKKKGIRINRFPGIEAMLEILKLAEDLKIPIYFLGAKKEVVESMVNRIKIRYPNLVIAGYRDGYFKREEEENIISEINNSGAKILFVALGFPKQEFFIDKYKDKLKVNIAIGVGGSFDVLSGKKKRAPKIIRELNLEWFYRLLQDPKRILSRFPNLIRFIRFYFRYKDHEEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0V1</accession>
    <name>B8E0V1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583766.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353302.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1414"/>
    <dbReference type="EnsemblBacteria" id="ACK42688">
        <property type="protein sequence ID" value="ACK42688"/>
        <property type="gene ID" value="Dtur_1414"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1414"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1461"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039478_0_2_0"/>
    <dbReference type="InParanoid" id="B8E0V1"/>
    <dbReference type="OMA" id="YELTTIM"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, using agmatinase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="295" mass="33933" checksum="D4446D0778A61A85" modified="2009-03-03" version="1">MQQYRYTPSFGGLPSRNPEDSKVLIISCPLETTTTYKKGTREGPQAILLASYNLELYDEELDDIPAEVGIYTHPDLSLSLGNLKKALEEIENFTFNIIDYKHFPVFLGGEHTITKAILRAYTKKYDSFSILHLDAHSDLRGEYEGTENSHACALREASEKIKIVQVGIRSMSEEEKDYVKERENIKIYFDYKLQEKFDAFVVEDILKNLEEEVYITLDFDVFNPSEMPAVGTPEPGGLSWYQVLYLLREVFKNKKVIGADFVEFSPIPGLVYPDYMAARLIYKTIGYYKKYSLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0W4</accession>
    <name>B8E0W4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583779.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353315.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1427"/>
    <dbReference type="EnsemblBacteria" id="ACK42701">
        <property type="protein sequence ID" value="ACK42701"/>
        <property type="gene ID" value="Dtur_1427"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1427"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1474"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017652_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0W4"/>
    <dbReference type="OMA" id="NRPIMEH"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_I" evidence="3">
        <location>
            <begin position="383"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="4">
        <location>
            <begin position="533"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="5">
        <location>
            <begin position="633"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="827" mass="93345" checksum="8E49774F3EC1D94B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0W9</accession>
    <name>B8E0W9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583784.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353320.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1432"/>
    <dbReference type="EnsemblBacteria" id="ACK42706">
        <property type="protein sequence ID" value="ACK42706"/>
        <property type="gene ID" value="Dtur_1432"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1432"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="InParanoid" id="B8E0W9"/>
    <dbReference type="OMA" id="SHQVELM"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="260" mass="29893" checksum="CF6147485DF7CB58" modified="2009-03-03" version="1">MIKFINVSAGYKNKIVIKDFYWETPNQGFVGIIGPNGAGKTTLFRLLIKYIEPTKGEIFIEDQNLKYIKQEEIGKKIALLPQKPFFEINLAVEEYVSLGRYPHHPYWRPLSKEDINKINESLNITNTMHLRKKKLAELSGGEQQRVLLARVLAQNPRILLLDEPTNSLDPFYQILFLNFVKKLSSKILVISSLHDINMASIYSDHILAIKNGRLITYGETNKVLSKALLEEIFHVKYTEINFEGKKFFLPTTLPIGKTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8E101</accession>
    <name>B8E101_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="7">S12 MTTase</shortName>
            <shortName evidence="7">S12 methylthiotransferase</shortName>
            <ecNumber evidence="7">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rimO</name>
        <name evidence="11" type="ordered locus">Dtur_1464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583816.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353352.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1464"/>
    <dbReference type="EnsemblBacteria" id="ACK42738">
        <property type="protein sequence ID" value="ACK42738"/>
        <property type="gene ID" value="Dtur_1464"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1464"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1513"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_0_1_0"/>
    <dbReference type="InParanoid" id="B8E101"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035599">
        <property type="term" value="F:aspartic acid methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="140"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="373"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="440" mass="51290" checksum="60E2D1A5116E43E7" modified="2009-03-03" version="1">MKKAGVIHLGCSKNQVDTEVLMGFLKNLGYTFTPHSEEADLILVNTCAFIKPAWQEAEENISLLEKYKKINENLKIVVVGCYVERFKEELENKYPFVDLFIGPGEYEKFVSLITSNGKRGIYSSPASSFIYNHKMPRILISPNFWVYVKIAEGCNNFCSYCTIPFIRGRLRSRSIEDIVKEIEIWIGKGVKEVNLIAQDTTRYGEDLYGRPSLVDLLRNIEKIRGDFYVRILYSYPSRISEKLIEAIKNSEKVVPYFDIPIQHVSDVILKRMNRSYKKDDIIKLWHRIKENFENAVIRTTVMVGFPGETEENFEELIDFIKKYPFDRLGAFIYYNENGTISKGFENQVDEDEKLRRYEILMETQKKISKKLNAKLLGKEFDVIIEDEKGKYFVGRSWREAPEVDGLIMIPKEKEKTLKIGSKVRVKIKKYRSYDLLGELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E115</accession>
    <name>B8E115_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1478</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583830.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353366.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1478"/>
    <dbReference type="EnsemblBacteria" id="ACK42752">
        <property type="protein sequence ID" value="ACK42752"/>
        <property type="gene ID" value="Dtur_1478"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1478"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1527"/>
    <dbReference type="eggNOG" id="COG1623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_787128_0_0_0"/>
    <dbReference type="InParanoid" id="B8E115"/>
    <dbReference type="OMA" id="VVRDYVP"/>
    <dbReference type="OrthoDB" id="1139866at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038331">
        <property type="entry name" value="DisA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018906">
        <property type="entry name" value="DNA_integrity_scan_DisA_link"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10635">
        <property type="entry name" value="DisA-linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAC" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="351" mass="39817" checksum="00C6AF890342607B" modified="2009-03-03" version="1">MAELKKFALQALRFVAPGTPLRESLEQIVKAKTGALIVVGEIEKVRPLMNGGFPLDIDFTPNRLYELSKMDGAIILSKDGKKILFANVILLPDPTISSSETGARHATAERVAKQTGCLVISVSQRKDTITLFQNDWKYVLRDVEEILTKASQALQTMERYRNIYDDLLNRLNSLELENQVNIYEVLSFLHRACMLFTIGKEVENYLIELGVEGRLIEIQLEVLLTGVKEETVLVIKDYAKKDKDPEDILRELVANFRGNFQEFSYIAGEILGYRKEEIDTGIIVVSKGYRILNRIASIPSSVIEKIVNYFGDLPRILESSFEDLDNIEGVGEVRAKKIREALTRMQRILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>B8E127</accession>
    <name>B8E127_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tyrS</name>
        <name evidence="11" type="ordered locus">Dtur_1490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583842.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353378.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1490"/>
    <dbReference type="EnsemblBacteria" id="ACK42764">
        <property type="protein sequence ID" value="ACK42764"/>
        <property type="gene ID" value="Dtur_1490"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1490"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1539"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_5_0_0"/>
    <dbReference type="InParanoid" id="B8E127"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043039">
        <property type="term" value="P:tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02007">
        <property type="entry name" value="Tyr_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024108">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF1">
        <property type="entry name" value="PTHR11766:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="10">
        <location>
            <begin position="343"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="232"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="404" mass="46422" checksum="3D6732A818A882A8" modified="2009-03-03" version="1">MRKLSIEEELEILKSNVVEIIPEDGLYEKLKKAREEGRPLRVKLGADPSAPDLHLGHAVVLRKLKQFQDLGHQVVFIIGDFTARIGDPSGRSETRKPLTPDQVKRNALTYQEQVGKILDVTKAEIRYQEEWFGKMKLEDVLVLTSKYTIARMLERDDFAQRFKEQKPIFIHEIMYPLLQAYDSVAIKADIELGGTDQKFNLIVGREIQREYGLEPQVAMLMPILEGLDGKQKMSKSLGNYIGLTEPPNEMYGKVMSIPDELIIRYYELATELTKEEIRKIEQEMKEGKLNPRDAKARLAREIVKIYHGEEASLKAEEEFNRIFRNKELPENVPEVEISEPKIWVVKLLTQVGAAKSNSEAKRLISQGAVEIDGTRIEDINLDITIDKPFILRVGKHFFRRIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E156</accession>
    <name>B8E156_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583268.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352798.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0903"/>
    <dbReference type="EnsemblBacteria" id="ACK42184">
        <property type="protein sequence ID" value="ACK42184"/>
        <property type="gene ID" value="Dtur_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0903"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.940"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_0_0"/>
    <dbReference type="InParanoid" id="B8E156"/>
    <dbReference type="OMA" id="ENDHQIN"/>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="218" mass="25501" checksum="3AE9719B8E8E55C4" modified="2009-03-03" version="1">MEKATIIKEIESLKEKLLRMGSIVEKMLHKTLDSIKTRDLDLAQEVIETDKLVDDYNWNIENQCIKILSLHQPVAKELRIIASTMKIIKDLERIGDYSVDIAKFASSLLKYSFEIPLADIISLATLVEKMVKDIIRAYSEPNLDQLEDLSSYYNFVYLKYQEISNELLEEIYKNPILTQQIVQLIMISRYLERIADHATNIIELIYYIETGERKELHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8E157</accession>
    <name>B8E157_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583269.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352799.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0904"/>
    <dbReference type="EnsemblBacteria" id="ACK42185">
        <property type="protein sequence ID" value="ACK42185"/>
        <property type="gene ID" value="Dtur_0904"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0904"/>
    <dbReference type="eggNOG" id="ENOG5033A7X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1352839_0_0_0"/>
    <dbReference type="OMA" id="SLMEKEY"/>
    <dbReference type="OrthoDB" id="1556178at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="202" mass="24169" checksum="0D1B0CA67C8E8684" modified="2009-03-03" version="1">MSRCISCNKKKGKRRCPALSGLICTECCGTKRLKEINCPPDCTYLKEAQLYSIVRVEEKPADFQRKQWDLFWYFESLIYKFLLEFSSFTDEELLDVISLMEKEYQTRKKNLFLPSLHPRSTRASKLKSILEEEFTKLEKQVNDFGLPIFTLDDFLKVLSFEKERIERYMRKNRNVGNNLFIQVLRSEVEAFTVQRRREKIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E174</accession>
    <name>B8E174_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methionine adenosyltransferase</fullName>
            <ecNumber evidence="2">2.5.1.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AdoMet synthetase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583286.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352816.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0921"/>
    <dbReference type="EnsemblBacteria" id="ACK42202">
        <property type="protein sequence ID" value="ACK42202"/>
        <property type="gene ID" value="Dtur_0921"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0921"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.958"/>
    <dbReference type="eggNOG" id="COG1812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057642_0_0_0"/>
    <dbReference type="InParanoid" id="B8E174"/>
    <dbReference type="OMA" id="IGHPDSI"/>
    <dbReference type="OrthoDB" id="468241at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042543">
        <property type="entry name" value="AdoMet_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027790">
        <property type="entry name" value="AdoMet_synthase_2_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042544">
        <property type="entry name" value="AdoMet_synthase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697">
        <property type="entry name" value="PTHR36697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01941">
        <property type="entry name" value="AdoMet_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="404" mass="45217" checksum="E1F3F333C4E4CC3E" modified="2009-03-03" version="1">MRNIVVEKLNSLPVEEHGVELVERKGIGHPDSICDAIMDQISVNLSQEYIKRVGNILHHNIDKSLLVAGEVERKLGVGGEVKKPMLLVIGDRATFEVDGIRIPVEEIAIETAKEWFRKNLRFVDPDKHVKFQVELYPGSPELTDIFRRRKGLLPANDTSAAVGYAPLTSTEKIVLELERYLNSKEFKAIHPEVGEDIKIMAFRQKKNLQLTIAMPLIDRYVTSVKDYFEKKEVIKSIVEDFVSEKAQNFENITIDINTLDDPERGMDGIYVSVLGTSAEDADSGQVGRGNRVNGVIALNRPMGTEAAAGKNPVSHVGKIYNILTHKIANEIYQKVPGIKEVYVWLCSQIGKPIDQPKIATAQLILENGTSIYDVAKPVEDIIDQELANIEKFCNELAEGKYSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E179</accession>
    <name>B8E179_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583291.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352821.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0926"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42207">
        <property type="protein sequence ID" value="ACK42207"/>
        <property type="gene ID" value="Dtur_0926"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0926"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.963"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041001_0_0_0"/>
    <dbReference type="InParanoid" id="B8E179"/>
    <dbReference type="OMA" id="QLHICYC"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="193"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="364" mass="42153" checksum="2E12C1365674FD2B" modified="2009-03-03" version="1">MRVAVVHDWIVNIGGAEKVLKAILELFPDADVYTLVYLKDTLRKLGINNKVYSSFISGLPFAKTKYSYYLPLMPLAIEQFDLSKYDLVISSSHCVAKGVLTKSYQIHICYCHTPMRYIWDLYFPYLKEHKLENGIKGIFVKPILHYLRIWDVSSANRVDYFVANSQNVANRIRKIYRRDSVVIYPPVDVERFLPSYKKEDYFMVLSRLVPYKKVDLVVETFNELNLPLVVIGDGEEMGKIKKMAKENIKILGWQEDDVVKEYLAKAQALIFASEEDFGIVSVEAQACGTPVIAYNRGGAKETVIDGETGILFEEQNVESLKKAVLRFLKERDNFQRDKIMENAKRFSEDRFKREFKSYIEGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1B0</accession>
    <name>B8E1B0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ordered locus">Dtur_0958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583322.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352852.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0958"/>
    <dbReference type="EnsemblBacteria" id="ACK42238">
        <property type="protein sequence ID" value="ACK42238"/>
        <property type="gene ID" value="Dtur_0958"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0958"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.995"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1B0"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051085">
        <property type="term" value="P:chaperone cofactor-dependent protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="96" mass="10655" checksum="2BFD640BE53FB976" modified="2009-03-03" version="1">MKLRPIGDRVVVKVIEQEEKTKGGIVLPDTAKEKPQQGRVIAVGTGRILDNGQKVPLEIKEGDRVIFAKYAGTEVKIEGEEYLILSERDILAVIEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1E9</accession>
    <name>RL18_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplR</name>
        <name type="ordered locus">Dtur_0997</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583361.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352891.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1E9"/>
    <dbReference type="SMR" id="B8E1E9"/>
    <dbReference type="STRING" id="515635.Dtur_0997"/>
    <dbReference type="EnsemblBacteria" id="ACK42277">
        <property type="protein sequence ID" value="ACK42277"/>
        <property type="gene ID" value="Dtur_0997"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0997"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1034"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1E9"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000142655" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <sequence length="122" mass="13883" checksum="D3FB508C2C88C8E1" modified="2009-03-03" version="1">MIIKRSRKELRRIRHLRIRKKITGTPERPRLAVYKSLRYIYAQIIDDTKGHTLVAASSLEKELRSQLKSTKNIEAAKLVGEVIAKRALEKGIKRVVFDRGGFLYHGKVKALADSARAAGLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1I6</accession>
    <name>B8E1I6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Glutamine-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="5 6">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadE</name>
        <name evidence="9" type="ordered locus">Dtur_0182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + deamido-NAD(+) + H2O + L-glutamine = AMP + diphosphate + H(+) + L-glutamate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:24384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="5 6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582596.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352125.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0182"/>
    <dbReference type="EnsemblBacteria" id="ACK41511">
        <property type="protein sequence ID" value="ACK41511"/>
        <property type="gene ID" value="Dtur_0182"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0182"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.188"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022313_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1I6"/>
    <dbReference type="OMA" id="CEDHFYE"/>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006630">
        <property type="entry name" value="NADS_GAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for glutaminase activity" evidence="5">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="For glutaminase activity" evidence="5">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="277"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR006630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="526" mass="59553" checksum="2E40F776E6948CE6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1K5</accession>
    <name>B8E1K5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycerophosphoryl diester phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582615.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352144.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0201"/>
    <dbReference type="EnsemblBacteria" id="ACK41530">
        <property type="protein sequence ID" value="ACK41530"/>
        <property type="gene ID" value="Dtur_0201"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0201"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.209"/>
    <dbReference type="eggNOG" id="COG0584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030006_3_3_0"/>
    <dbReference type="InParanoid" id="B8E1K5"/>
    <dbReference type="OMA" id="CQILHCL"/>
    <dbReference type="OrthoDB" id="1542724at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="SSF51695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="323" mass="38057" checksum="AE28DC1FD23E34CA" modified="2009-03-03" version="1">MLILGHRGCAYFPENTLKSFEEALKTSDGIELDVQKTKDGVLTLSHDESLLRLTGIDKNIRESKFDEIKDIKIQGEKIAKLEEALALVKNMKKFVDIEVKNPEDFREVYEVVKKFDLKEYIISSFWHDGLYRLKKEDSKIKIAFLYVHQPTKSELENYLAKSDFLKPNFNYVHEIYEGYYHRLIPWTVNDVEKAKFFKSINVFAIISDFPDKIHEGIKEEKNMFFSNPYLSYFIQMIDRNSIKRDNKTFSFEAVNYIMPLHIEEINIEGGKIEVNKETPFSWNQGERIRFTITIEEEDPKIKIRVREIGEVIFSLKDIQKALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1L7</accession>
    <name>B8E1L7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582627.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352156.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0213"/>
    <dbReference type="EnsemblBacteria" id="ACK41542">
        <property type="protein sequence ID" value="ACK41542"/>
        <property type="gene ID" value="Dtur_0213"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0213"/>
    <dbReference type="eggNOG" id="ENOG5033JRJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_568302_0_0_0"/>
    <dbReference type="OMA" id="IVNSMIN"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="480" mass="55715" checksum="3D13FE151550C467" modified="2009-03-03" version="1">MKKEFWWLKYPTLILLKEIQKVNKNMDKSIENLKDYIYEILVQEFKEHNCEVILWKKEQDKKVKNNYAIIINPVFLGKLDSKIEEVLKNNKLPEDNEILKESLPEVNPPFAISIGRKVCKNLEIYPELHPNFINLVFIEDNINIHSLSSNTKVQLIRFLMAKLGAFKNIIVPYKGENISENKVILGTLEGGHPSLRIEDLAKRLMVFGSCKEVGGYEEIDWEIKEDVWKKSKIVNSMINLGKFLGEKKLLSEPVEIRNLVKDENLAKLIVRLVNYSRQAEGAFMAFEPEIKPPKELNFMNGIFIVTCSGKYGTVKSNLSYKDLAPIIPLKNGKVGVFKKEKEETIGPSVEAEEFTLPLLEMKEKLDYLPIIGVVHLHRGYKILNPSSKFFYIPIDIREYPPVGCGVDLMQEMSKYAMKKAVEIWEERKKLPYFALFYVPNHGTNIFIFPKDNFNIYEDPFYYFKESVDLKELIFTDVPQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1M1</accession>
    <name>B8E1M1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582631.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352160.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0217"/>
    <dbReference type="EnsemblBacteria" id="ACK41546">
        <property type="protein sequence ID" value="ACK41546"/>
        <property type="gene ID" value="Dtur_0217"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0217"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8E1M1"/>
    <dbReference type="OMA" id="IADRMII"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="331" mass="37097" checksum="F405ECC6828B64B0" modified="2009-03-03" version="1">MKGTLIINLDNVKAYYARGDTYVKAVDGVTLNVYKGEVVGIVGESGSGKSTLSNVMIMNIKKPLTFIDGKVTLNAGADFLELNKMPRQELQKIVWGRETSIVPQAAMNALMPTKKIRDFISDLVKDHFERALNEEEIVERAKQRFTDVGISPNDIYRYPFELSGGMRQRAVIAIATLLNPRLLICDEPTSALDVANQKLVLKTLEQLRKREIVESIVFITHDIATVRQIATRMVVMYAGKIVENSSVDDIIKDPLHPYTKGLLLSVVTPEPEVKKRGISYIPGTPPDLANPPHGCRFHTRCPYKMPICEEQEPALKKIDTNREVACFLFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1N9</accession>
    <name>B8E1N9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582649.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352178.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0235"/>
    <dbReference type="EnsemblBacteria" id="ACK41564">
        <property type="protein sequence ID" value="ACK41564"/>
        <property type="gene ID" value="Dtur_0235"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0235"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_485504_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1N9"/>
    <dbReference type="OMA" id="YVGKGNF"/>
    <dbReference type="OrthoDB" id="1149750at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024163">
        <property type="entry name" value="Aerotolerance_reg_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07584">
        <property type="entry name" value="BatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="BatA" evidence="2">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="92"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="561" mass="65176" checksum="ADBB5E22AF82C6DA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1P9</accession>
    <name>B8E1P9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Formylmethanofuran dehydrogenase subunit E region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582659.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352188.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0248"/>
    <dbReference type="EnsemblBacteria" id="ACK41574">
        <property type="protein sequence ID" value="ACK41574"/>
        <property type="gene ID" value="Dtur_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0248"/>
    <dbReference type="eggNOG" id="COG1720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077622_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1P9"/>
    <dbReference type="OMA" id="GWDCVFS"/>
    <dbReference type="OrthoDB" id="1454794at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003814">
        <property type="entry name" value="FmdEsu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023368">
        <property type="entry name" value="UPF0066_cons_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02663">
        <property type="entry name" value="FmdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="SSF118196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01318">
        <property type="entry name" value="TSAA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TsaA-like" evidence="6">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="311" mass="35739" checksum="5DDF66C3B241534A" modified="2009-03-03" version="1">MELKPIGVIHSPYKTKEEAPFQGRWAEDLKESVIEIFEEYRDAMQGLENVKHIIVLYWCDRADRNRLKTITPWGPEEKGVFSTRSPSRPNPIAFSIGEIRKIEGNKIYVLGLDAIDKSPLLDIKVYVYDIDAIKRPRKKVVFNSALWDECVSFHGHSCPGLAIGYKAVEAVVSKLKISFSEDEEIVCITENNACGVDAIQYILGCTFGKGNLIFKDRGKQAFTFFVRDTGEGVRIVLKDLPRREDREKWTKELLKMNVEDMFEFQAPRDEIPKRARIYPSLKCEICGEKASERNMRIKEGKIVCMDCFEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1T0</accession>
    <name>B8E1T0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, LacI family</fullName>
            <ecNumber evidence="6">5.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582798.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352327.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0409"/>
    <dbReference type="EnsemblBacteria" id="ACK41713">
        <property type="protein sequence ID" value="ACK41713"/>
        <property type="gene ID" value="Dtur_0409"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0409"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.432"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="InParanoid" id="B8E1T0"/>
    <dbReference type="OMA" id="HSEFVFM"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="342" mass="37909" checksum="A3998C0C3AFA2CAA" modified="2009-03-03" version="1">MVTIKDVAKRAGVSVMTVSRVINGSKNVKESTREKVLKAIEELGYVPNSVARSLILKKTLTIGLVISDITNPFFTTIARGVEDTAISKHFTVILCNTDENPEKEMMYAEVLAKSKVDGVIYASASGKKTPLKSLFLKNIPIVLIDRTIEGVNDLDIVRGDSVLGAYLLTKHLIDLGHRRIGIIVGSHFISTARDRVEGYKKALNEANIPIDESLIKINKNSKFSKDDGYRLTKELLDLENPPTAIFGGNNLMAVGALLAIRERGLEIPDDISLVSFDDIESLSEVYPFLTVVKQPAYTMGVIATELLIRRIEDKDRIKEKREILLTPELIIRKSTAPPKRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1T1</accession>
    <name>B8E1T1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">L-fucose isomerase</fullName>
            <shortName evidence="7">FucIase</shortName>
            <ecNumber evidence="7">5.3.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-deoxy-L-galactose isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fucI</name>
        <name evidence="11" type="ordered locus">Dtur_0410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Converts the aldose L-fucose into the corresponding ketose L-fuculose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-fucose = L-fuculose</text>
            <dbReference type="Rhea" id="RHEA:17233"/>
            <dbReference type="ChEBI" id="CHEBI:2181"/>
            <dbReference type="ChEBI" id="CHEBI:17617"/>
            <dbReference type="EC" id="5.3.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the L-fucose isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.25" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582799.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352328.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8E1T1"/>
    <dbReference type="STRING" id="515635.Dtur_0410"/>
    <dbReference type="EnsemblBacteria" id="ACK41714">
        <property type="protein sequence ID" value="ACK41714"/>
        <property type="gene ID" value="Dtur_0410"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0410"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.433"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033326_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1T1"/>
    <dbReference type="OMA" id="QDYRACA"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="BRENDA" id="5.3.1.25">
        <property type="organism ID" value="13721"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00563">
        <property type="reaction ID" value="UER00624"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008790">
        <property type="term" value="F:arabinose isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019571">
        <property type="term" value="P:D-arabinose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042355">
        <property type="term" value="P:L-fucose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.14.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01254">
        <property type="entry name" value="Fucose_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004216">
        <property type="entry name" value="Fuc/Ara_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038393">
        <property type="entry name" value="Fuc_iso_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038391">
        <property type="entry name" value="Fucose_iso_dom1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012888">
        <property type="entry name" value="Fucose_iso_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005763">
        <property type="entry name" value="Fucose_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038392">
        <property type="entry name" value="Fucose_isomerase_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012889">
        <property type="entry name" value="Fucose_isomerase_N2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07881">
        <property type="entry name" value="Fucose_iso_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07882">
        <property type="entry name" value="Fucose_iso_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50443">
        <property type="entry name" value="SSF50443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01089">
        <property type="entry name" value="fucI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_N1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_N2" evidence="10">
        <location>
            <begin position="187"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Fucose_iso_C" evidence="8">
        <location>
            <begin position="402"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="606" mass="68363" checksum="7742CF4A361C9DCF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1T5</accession>
    <name>B8E1T5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autoinducer 2-binding protein LsrB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0414</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582803.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352332.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0414"/>
    <dbReference type="EnsemblBacteria" id="ACK41718">
        <property type="protein sequence ID" value="ACK41718"/>
        <property type="gene ID" value="Dtur_0414"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0414"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.437"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_0_0"/>
    <dbReference type="InParanoid" id="B8E1T5"/>
    <dbReference type="OMA" id="KQVNNPY"/>
    <dbReference type="OrthoDB" id="669710at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015762">
        <property type="term" value="P:rhamnose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030159">
        <property type="entry name" value="LsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013459">
        <property type="entry name" value="RhaS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46847:SF4">
        <property type="entry name" value="PTHR46847:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02637">
        <property type="entry name" value="RhaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="7">
        <location>
            <begin position="28"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="334" mass="36375" checksum="3055D26360B9155F" modified="2009-03-03" version="1">MKKFLIVLLLVLLIVLGTESFAQKKYVIGLVTKTAGNPFFEAVNKGAQEAAKELGITVIHQAPAASSVQGQIDIINSMIAQKVSAICISANDPDALVPVCRKAQLRGIPVVTFDSAVKPQGRKLFVNQADMEQIGRIQVQLLAKMINYEGEIAILSAASTMANQNTWIAWMKEELKKPEYSKMKLVAIVYGDDIREKSYNEAMGLFKSYPNLKGIIAPTTVGIAAAARAIEDAGLSGKVQLTGLGLPSEMAEYVKRGTCKAFALWNPIDLGYATIYATYRLLNREIKGNVGEKVNLGRLGERTIVDEGNGGRMIILGPPFVFDAANIDYWSKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Y4</accession>
    <name>B8E1Y4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M15A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582852.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352381.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0467"/>
    <dbReference type="EnsemblBacteria" id="ACK41767">
        <property type="protein sequence ID" value="ACK41767"/>
        <property type="gene ID" value="Dtur_0467"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0467"/>
    <dbReference type="eggNOG" id="COG3108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124897_1_0_0"/>
    <dbReference type="OMA" id="GMACDIT"/>
    <dbReference type="OrthoDB" id="2028958at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013230">
        <property type="entry name" value="Peptidase_M15A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08291">
        <property type="entry name" value="Peptidase_M15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M15_3" evidence="1">
        <location>
            <begin position="24"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="110" mass="12743" checksum="42D25EA275A792B0" modified="2009-03-03" version="1">MLRINEIKVSKNFYLKDFECPCCNKVMLHPTLLENLEKLIASGLKIKITSGYRCEKHNKEVKGVPNSKHMKGMACDITCNDIEKAYEMAQKLGFSYVKIDKLKKYIHMEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E200</accession>
    <name>TAL_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transaldolase</fullName>
            <ecNumber evidence="1">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tal</name>
        <name type="ordered locus">Dtur_0485</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582868.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352397.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E200"/>
    <dbReference type="SMR" id="B8E200"/>
    <dbReference type="STRING" id="515635.Dtur_0485"/>
    <dbReference type="PRIDE" id="B8E200"/>
    <dbReference type="EnsemblBacteria" id="ACK41783">
        <property type="protein sequence ID" value="ACK41783"/>
        <property type="gene ID" value="Dtur_0485"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0485"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.510"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079764_0_0_0"/>
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    <dbReference type="OMA" id="VRHPMHV"/>
    <dbReference type="OrthoDB" id="784333at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0570">Pentose shunt</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000126311" description="Probable transaldolase">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <sequence length="214" mass="23618" checksum="114E83AA1BCD2AC5" modified="2009-03-03" version="1">MKLFLDTANIQEIKEAWSLGIIDGVTTNPTHISKENKKFRELIEEICSIVDGPISVEAVSLKAEEIVREAEELSKISPNIVVKIPAIKEGIKAAKILSEKGIKTNITLVFSPSQALLAGKVGATYVSPFVGRLNDISEEGINLVADIKKIYSNYGFKTQIIVSAIRNPMHVVKAALIGADVATMRFDILMSLFRHPMTDLGLEQFLKDWEKVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E206</accession>
    <name>B8E206_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-fucose isomerase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582874.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352403.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0491"/>
    <dbReference type="EnsemblBacteria" id="ACK41789">
        <property type="protein sequence ID" value="ACK41789"/>
        <property type="gene ID" value="Dtur_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0491"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045643_1_0_0"/>
    <dbReference type="InParanoid" id="B8E206"/>
    <dbReference type="OMA" id="ECPRERM"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="439" mass="50393" checksum="23C99715C5F08ED2" modified="2009-03-03" version="1">MLKLGFLGVTQKTFKSQKEDIYNRSIDVLLKLSQKLSFELIYSPSLIEDPFILQKILEEWQDKIDFLLFQTTTFAGGFLGEILAKSDLPVIFWAIPELEIKGNLKWNSLCSLNFFASLIKKFNPKKKFDWIYTFPEEENKELIEILKVLKILKNLKSLKIIHLVGTAPGFFNLEVSYELLKSKFGIEIKNYPSLDIIVEIIKSLDKNELEKTKEEIKKIINIPIEEKWLDEGLKIAIALEELAKKENAKAIASRCWPDFRETLSIFPCFSFAIVSEKIPVSCEGDILSALGMYILKEISEKPTSVLDLVYYDNKSIILWHCGNTSLSLTKPPISLDYQFNHPGMGSTIDSKFKEGEVTLFSFNQDLKNALIFSGKISYPFESKFKGSFAYITDLPIKPRELFDTIVKEGFPHHLVLSYGNFVALIKKVLYWLEIPSITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E213</accession>
    <name>B8E213_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Regulatory protein GntR HTH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582881.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352410.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0503"/>
    <dbReference type="EnsemblBacteria" id="ACK41796">
        <property type="protein sequence ID" value="ACK41796"/>
        <property type="gene ID" value="Dtur_0503"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0503"/>
    <dbReference type="eggNOG" id="COG2186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_9_1_0"/>
    <dbReference type="InParanoid" id="B8E213"/>
    <dbReference type="OMA" id="ETDTTAW"/>
    <dbReference type="OrthoDB" id="1875458at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="228" mass="26913" checksum="207A70AA332F8297" modified="2009-03-03" version="1">MKPVTRTKLTESIIKAIMEYVNSQNLKVGDRLPSERDLSKALKVSRPLLREAIRVMEGLNLIEVKPGSGIFIKNPLGPDFSYLVLHIDLQEKERLLETLKVRKVLEKLAIEETLKNIDPEKLSRLEKLLTTLEEAIRRGDSGLEEIWNYYSTIYQFSNNKFLFSFLDGLKNIYLSWIDPQENPVFAEKTYSYHRELFEAIKNKDLNKISLLIDRFYKIWQEEIEKRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E219</accession>
    <name>B8E219_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582887.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352416.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0509"/>
    <dbReference type="EnsemblBacteria" id="ACK41802">
        <property type="protein sequence ID" value="ACK41802"/>
        <property type="gene ID" value="Dtur_0509"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0509"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.540"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="InParanoid" id="B8E219"/>
    <dbReference type="OMA" id="VYTEFMG"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="335" mass="37415" checksum="2F1453A11D5AAB06" modified="2009-03-03" version="1">MSRSKKKVTISDIAKKAGVSVGTVSRVLNKADNVNEEIKEKVLKAAITLGYEMEIKRRGTLGTVGFVIRELENDPTQNVYFSAILRGAQKRTEELGGRLIYTVVQNTDDKIREVVSKVKSLKVDALLLVNLSNAKLVEEILKLSIPSVVMEDYFPELEVDCITTDAFDGACKVAKFLLEKHKKIAFIDGPQDQYDVVQRAAGFIFTLERMGNPIDPDLIEYSDLLPEGGYRAMKKLLEKGKKFTAVYCTNDHSAIGAIRAIKEEGLRIPEDISIVGNDDIDIAQHLDPPLTTVRVFRETLGKVAVDHLYNRIINPYDVVLKIVIPEELVIRKSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E223</accession>
    <name>B8E223_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="ordered locus">Dtur_1020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583383.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352914.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1020"/>
    <dbReference type="EnsemblBacteria" id="ACK42300">
        <property type="protein sequence ID" value="ACK42300"/>
        <property type="gene ID" value="Dtur_1020"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1020"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1057"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_0"/>
    <dbReference type="InParanoid" id="B8E223"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="289"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="457"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="608" mass="69326" checksum="3D01ADF6A9B76589" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E225</accession>
    <name>B8E225_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583385.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352916.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1022"/>
    <dbReference type="EnsemblBacteria" id="ACK42302">
        <property type="protein sequence ID" value="ACK42302"/>
        <property type="gene ID" value="Dtur_1022"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1022"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_902339_0_0_0"/>
    <dbReference type="OMA" id="HIWDIVE"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="308" mass="36157" checksum="0DF3B69BFB525353" modified="2009-03-03" version="1">MKDSPIELLREKVADLRKLISKILVPTQSESKRYAEDFILKRQEIQELVEDIRRLGISIEAELVELSEIDGEVKKNLDTIYKLLKNSDLKSKGNTYPRDYWWWHIWDIVEKKRKRKIKRITIYSLLTVLILIGVVILSNYFKPSSQEIIETMDSSYKYLSEGKVDMAQRVLEEKIEKYNNSPDLWLSLGIVLEHKDVKKAKEAFDKSLKLYKTKKDFLINRAIQYKKLGFYEKAERDLEEVLSMDKDNSQALYILATIFEEKKQIGEAIKIYKRIEELGDKADPQILVMSKMRLITLLQSSNLPSDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E230</accession>
    <name>B8E230_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352921.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1027"/>
    <dbReference type="EnsemblBacteria" id="ACK42307">
        <property type="protein sequence ID" value="ACK42307"/>
        <property type="gene ID" value="Dtur_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1027"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1649442_0_0_0"/>
    <dbReference type="OMA" id="YEIMQCL"/>
    <dbReference type="OrthoDB" id="2102501at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="159" mass="18168" checksum="A0B7C255F375266F" modified="2009-03-03" version="1">MYNRGFTLIELLLTFVILGIIATITLNFSLAIIDERKMLQKSYEIMQCLVEVRGGAFTKEEDYPDLVCFYPFSDLILVKTFDRVKNMYKVIKKIDLSQENIDLTSAVFGTNNYVYFNKLGIPSSGGTIAISYKSVRKYIIVTPATGRIYVSNEMPKSWD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E246</accession>
    <name>NUSB_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nusB</name>
        <name type="ordered locus">Dtur_1043</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583406.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352937.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E246"/>
    <dbReference type="SMR" id="B8E246"/>
    <dbReference type="STRING" id="515635.Dtur_1043"/>
    <dbReference type="EnsemblBacteria" id="ACK42323">
        <property type="protein sequence ID" value="ACK42323"/>
        <property type="gene ID" value="Dtur_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1043"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_3_0_0"/>
    <dbReference type="InParanoid" id="B8E246"/>
    <dbReference type="OMA" id="DRMPVVD"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0889">Transcription antitermination</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000192437" description="Transcription antitermination protein NusB">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <sequence length="144" mass="16729" checksum="980D7CE2A0BFE840" modified="2009-03-03" version="1">MSKERTRCREKVLEFLFQKDLGQEIEVDFSDFSPQGQVFAYKLYDGALYYKDLADEIISKFSKNWKLERIGTIEKNILRMAIAEMFTFSDIPQGVTVNEAVELAKKYVSPEAGRFINGILRNIVRNWDEVKKLKEGFVDVTSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E258</accession>
    <name>B8E258_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8 9">Chorismate synthase</fullName>
            <shortName evidence="8">CS</shortName>
            <ecNumber evidence="4 8 9">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aroC</name>
        <name evidence="10" type="ordered locus">Dtur_1055</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="8 9">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8 9">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4 8 9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583418.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352949.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1055"/>
    <dbReference type="EnsemblBacteria" id="ACK42335">
        <property type="protein sequence ID" value="ACK42335"/>
        <property type="gene ID" value="Dtur_1055"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1055"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1092"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_2_0_0"/>
    <dbReference type="InParanoid" id="B8E258"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8 9" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="306"/>
            <end position="310"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="388" mass="43787" checksum="4F35E461FF068545" modified="2009-03-03" version="1">MRFLTSGESHGKALMAILEGVPAGLHITSEYINKELRRRQIGYGRGKRMEIERDEVEIISGVRGGYTLGTPIGIVIKNRDWENWKNVMDPEEILEEKMVTKPRSGHADFAGAIKYHFEDIRNVLERASARETAARVAVGAIAKAFLSEFGIEIISFVEAIDSIENRFDINNFEWDVLKRKAEKSDLRMIDEEKERQAKELIDKAKEEGDTLGGRFVLLARGVPIGLGSHVHWDKRLDALISHAIMSIPSVKGVEIGEALYASLNKGSKVHDEFYFGENRLRKTNYAGGIEGGISNGEIIMVRAFVKPIPTLRRPLKTFDIKEKKITDGYYERSDVCVVPAAGVVGESMLAFVLAKEFLNKFSGDHISEIKESFEKYKKYVYERLGWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E267</accession>
    <name>B8E267_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583427.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352958.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1064"/>
    <dbReference type="EnsemblBacteria" id="ACK42344">
        <property type="protein sequence ID" value="ACK42344"/>
        <property type="gene ID" value="Dtur_1064"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1064"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_0"/>
    <dbReference type="InParanoid" id="B8E267"/>
    <dbReference type="OMA" id="PVMTLCC"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="131"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="354" mass="39981" checksum="76816C6F9FC5EC98" modified="2009-03-03" version="1">MNIEGIKKILTYFLKRAVAVFITIAIAIYLTIVIANAGGYVDKIIEDEIRMNVAMAIRNDPTVRGFTDEQKQKIIENRVKNEMRRRGLDQPFIIRSIYHLKRALLLDLGTASSMTSDSGSMLVKNIILERIPLSILLFTTITLINFFSALYLGLKLSRRYGSFLDKLIVYLSPLSTIPGWFYGIFLIMIFYSWLHILPPGGFIDFPPPPTLLGRILNIAKHMILPILSWFISSIFLSTYSERNFFLIYSTEDYVEVAKAKGLPDKIIERRYILRPALPPIITSFALALISSWMGAIVTEAVFNWPGLGMVLSRAIGSFDAPVIVGVTVIYAYLLGATVLLLDFIYALIDPRVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E270</accession>
    <name>B8E270_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamate synthase (NADPH), homotetrameric</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583430.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352961.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1068"/>
    <dbReference type="EnsemblBacteria" id="ACK42347">
        <property type="protein sequence ID" value="ACK42347"/>
        <property type="gene ID" value="Dtur_1068"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1068"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1104"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_0"/>
    <dbReference type="InParanoid" id="B8E270"/>
    <dbReference type="OMA" id="QETQCEQ"/>
    <dbReference type="OrthoDB" id="671513at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006004">
        <property type="entry name" value="Glut_synth_NADPH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01316">
        <property type="entry name" value="gltA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fer4_20" evidence="2">
        <location>
            <begin position="18"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="140"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="461" mass="50394" checksum="2DDC96C1185AC15A" modified="2009-03-03" version="1">MAIAKAKTPIPEQPVEQRVRNFDEVALGYTEEQALMEASRCLQCKDAPCVRGCPVNIDIPGFIRLIKEKKYDEAIKKIKENNNLPATTGRVCPQETQCEALCTLKKIGEPVAIGRLERFVADYELSKGYDIPLIKVRRDKRVAVVGSGPAGLTVAGDLARMGIKVSIFEAFHEPGGVLIYGIPEFRLPKRIVRAEVEYIKSLGVEIFTNVVVGRSITIDELLKEYDAVFIGTGAGAPQFLNIPGENLIGIYSANEFLTRVNLMKAYKFPEYDTPIKIGNIVGVIGGGNVAMDAARTALRLGAKEVHILYRRTEEEMPARYEEIIHAREEGIIFNFLVSPVRFIGDDKGQLIGIELQRMTLGEPDSSGRRRPIPIEGSNFIFSLDMAIVAIGTVPNPLISMTTPDLSINKNGTILIDKETGKTSKDRVFAGGDVASGSATVINAMGAGKIAAKSIFKLLVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E274</accession>
    <name>B8E274_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583434.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352965.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1072"/>
    <dbReference type="EnsemblBacteria" id="ACK42351">
        <property type="protein sequence ID" value="ACK42351"/>
        <property type="gene ID" value="Dtur_1072"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1072"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1108"/>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009942_3_1_0"/>
    <dbReference type="InParanoid" id="B8E274"/>
    <dbReference type="OMA" id="RDHHGAW"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="47"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="505" mass="57321" checksum="7A48476FB3FAC08F" modified="2009-03-03" version="1">MKKYFIKAKKIYTFDHQKSIYDTLLIENNKISDLGNNLIPKDTDIPIIDLSDYIILPGFIDSHVHLTSTAINEILIDLSNFTSIKEIVKALEALRDSLPEGDWIVAKEFDPVNLEEKRNITQEELDKNFPKHPVLIIRKDSHSSIINSLGMKLLDVEIFPENGLIKERDHQIAIGKVYQNIDPSLLVKGLIKTLKKAAEKGITTIHALEGGYTSPPNSPQLLLGLSQYFPIDVIIYYQTTSIKKVKELGLRRIGGCLLVDGSISTLTAAVSEPYLPNQGYGVLFWDMETLSNFIRTAHKEDLQIAFHAVGDRGIDLLVRAYQKVLKEIPKEDHRHRIEHFELPNKEHIKLASQLNLTLSLQPSFLYFWGGEGKLYEQLLGKERAKRIIPLRSILKEEITAGGGSDSSVTPMDPFLGIYSAINHPNEEERITLEEAIKMFTYNGAYIGFIEKEKGSIERNKDADLVILEKNPFEFREKEEILNIKIVATISRGRFVYKDTNLVTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2B4</accession>
    <name>B8E2B4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mnmG</name>
        <name evidence="11" type="synonym">gidA</name>
        <name evidence="14" type="ordered locus">Dtur_1112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 11">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the MnmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583474.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353005.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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        <property type="gene ID" value="Dtur_1112"/>
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    <dbReference type="OrthoDB" id="146811at2"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
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        <property type="entry name" value="MnmG_C"/>
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        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="GIDA" evidence="12">
        <location>
            <begin position="5"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="GIDA_C" evidence="13">
        <location>
            <begin position="397"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00003717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020461"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="619" mass="70226" checksum="61DE61F54F8CBD8A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2E9</accession>
    <name>B8E2E9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Elongator protein 3/MiaB/NifB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1519</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1519"/>
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    <dbReference type="KEGG" id="dtu:Dtur_1519"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
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        <property type="entry name" value="rSAM"/>
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        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Elp3" evidence="5">
        <location>
            <begin position="10"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="267" mass="30946" checksum="65722174D796BEE3" modified="2009-03-03" version="1">MTIKVTPISTLPISITGDYCALQCDHCKAHFLKNMTPLYLSENKLKKDNNYKSILISGGYNKEGVLPITDVHLTYLKRFKSMGYKLNFHLGLINEEDAKKLNGIPDMVSFDLIFDNFVIKEVFHLKSKNKENFKESFLLLNEHFPVSPHILIGANYGKISKEYEEIEFLEKINPKKLIFIVITPLKNTPFEKIDLPPIKEIEDLWKFAKKKLPNTDLYLGCVRPKGDYRYELDSLALEFEFKAIVNPYHDVMKNLDDNKFDQCCALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2F3</accession>
    <name>B8E2F3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583873.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353411.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1523"/>
    <dbReference type="EnsemblBacteria" id="ACK42797">
        <property type="protein sequence ID" value="ACK42797"/>
        <property type="gene ID" value="Dtur_1523"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1523"/>
    <dbReference type="HOGENOM" id="CLU_1624513_0_0_0"/>
    <dbReference type="OMA" id="QETWAPI"/>
    <dbReference type="OrthoDB" id="2117288at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="163" mass="18348" checksum="805594246E339FBF" modified="2009-03-03" version="1">MKRYVVLGVMLLLMLNIGLAKQSFVLDFTKNPPKGNLSYEISKGVDLEKEDGEYHLAFLKGGSSLKIYTPVSSLESPKRVILKLTGISSSLLSQETWAPIVILVNSKELVSGFDFGSDYYITPSFNISKYWLNGQTNIVEIRLDKDASGEFWLKKIEISIYEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2G6</accession>
    <name>B8E2G6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ordered locus">Dtur_1536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012547534.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353424.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1536"/>
    <dbReference type="EnsemblBacteria" id="ACK42810">
        <property type="protein sequence ID" value="ACK42810"/>
        <property type="gene ID" value="Dtur_1536"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1536"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2G6"/>
    <dbReference type="OMA" id="AVKMDKR"/>
    <dbReference type="OrthoDB" id="1940160at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="76" mass="8464" checksum="BB57854A01DF1BA0" modified="2009-03-03" version="1">MKELLEYIIKAIVQKPEEVEVREVEGTKSVILEVKVAPEDRGRVIGKQGQTVKALQTIVRVAGLKKGKKVVIEVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2K8</accession>
    <name>B8E2K8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583927.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353466.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1578"/>
    <dbReference type="ESTHER" id="dictd-b8e2k8">
        <property type="family name" value="AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42852">
        <property type="protein sequence ID" value="ACK42852"/>
        <property type="gene ID" value="Dtur_1578"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1578"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048353_3_2_0"/>
    <dbReference type="InParanoid" id="B8E2K8"/>
    <dbReference type="OMA" id="WSAVGYP"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="52"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="255" mass="28433" checksum="9B2134E2997EC93A" modified="2009-03-03" version="1">METREPVVLENQGQKIFGVIHIPEKTPAPFVLFCHGFTGTKVEPHRIFVKTAEALTREGIGALRIDFRGSGDSEGSFKDMTVEGEVSDAMIAIDYLARSNLVDKEKIGILGLSMGGAVASITSGRNSLIKSCVLWSAVCHFDIFFNRSPEEVSRIKDYGDFIDLGGNPVGKEFLSEIVNIKPLEEIKKRSIPVLIIHGGGDIVVPIQHAYDYFNGLKDTHKVKLEIIENADHTFNSIEWEEKVIEKTIKWFKETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2L9</accession>
    <name>B8E2L9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583938.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353477.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1590"/>
    <dbReference type="EnsemblBacteria" id="ACK42863">
        <property type="protein sequence ID" value="ACK42863"/>
        <property type="gene ID" value="Dtur_1590"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1590"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014011_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2L9"/>
    <dbReference type="OMA" id="TWTARNE"/>
    <dbReference type="OrthoDB" id="54422at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043751">
        <property type="entry name" value="DUF5696"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18952">
        <property type="entry name" value="DUF5696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="730" mass="84147" checksum="6E85762639716A09" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2N2</accession>
    <name>SECF_DICTD</name>
    <protein>
        <recommendedName>
            <fullName>Protein translocase subunit SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secF</name>
        <name type="ordered locus">Dtur_1603</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583951.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353490.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2N2"/>
    <dbReference type="SMR" id="B8E2N2"/>
    <dbReference type="STRING" id="515635.Dtur_1603"/>
    <dbReference type="EnsemblBacteria" id="ACK42876">
        <property type="protein sequence ID" value="ACK42876"/>
        <property type="gene ID" value="Dtur_1603"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1603"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1652"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050012_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2N2"/>
    <dbReference type="OMA" id="AFEWRMA"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000412694" description="Protein translocase subunit SecF">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <sequence length="290" mass="33188" checksum="0B4360DB012C1A3B" modified="2009-03-03" version="1">MKKEINFLGKRVRRVFMILSLLFVIIGMYFFFTKGLNYSIDFQSGSVIYYKLSSPLNSNQIANLRDIARSFYSKSTIQTGSNGKEVWIRTKFLEENELKRLTSEVEKVIVKYEGREITTIEPTISRELREKAILAAVLAIIVMLVYITVRFRFDFAISAIINEAFVLLATISIFAISQWEVSPSFIAAILTLLGYAINDNIIVFDRIRENSKKYPKEDFTIIANRSINQTLARTLYTVITTLLAITPLLIWGGVVLRPFILAIYLGIIIGTYSTIYIASAILCEWRELQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-09-21" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2N3</accession>
    <name>SECD_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secD</name>
        <name type="ordered locus">Dtur_1604</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583952.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353491.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2N3"/>
    <dbReference type="SMR" id="B8E2N3"/>
    <dbReference type="STRING" id="515635.Dtur_1604"/>
    <dbReference type="EnsemblBacteria" id="ACK42877">
        <property type="protein sequence ID" value="ACK42877"/>
        <property type="gene ID" value="Dtur_1604"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1604"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1653"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_4_2_0"/>
    <dbReference type="InParanoid" id="B8E2N3"/>
    <dbReference type="OMA" id="MVVYYRL"/>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000412676" description="Protein translocase subunit SecD">
        <location>
            <begin position="1"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <sequence length="399" mass="43438" checksum="1919A67C1DEABD7E" modified="2009-03-03" version="1">MNIRPEIKTAFIVIILGIAIWILLTFPFRYGLDIRGGIRVTLQCQKTEGVEITDDAVRRTIEVIRNRIDQLGVTEPSIYKEGSDKIVVELPGIKDPERALEIIGQTALLEFKDETGKTILTGSALKNAKVEFDQVGQPMVRVEMNPEGAKIFADFTSKNVGKQVFIVLDGKVISNPVIKEPITEGTGVITGRFTIDEAQKLAILLRAGALPVPVKVIENRTIDPTLGKDTMESAYRAGVIGAILVVLFMILVFRFLGLVADIALLIYVVLDLAALKLLNATLTLPGVAGIILSIGMAVDANCLIFARMKEEYAQRKTPMASLDAGFRNALRAIIDSNVTTILAALILFYFGTGPIRGFAVTLSLGVALSMFTQITITRTLLENLLSLPVFKKATKLLGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2T7</accession>
    <name>ISPH_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="1">HMBPP reductase</shortName>
            <ecNumber evidence="1">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispH</name>
        <name type="ordered locus">Dtur_1158</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583519.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353051.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2T7"/>
    <dbReference type="SMR" id="B8E2T7"/>
    <dbReference type="STRING" id="515635.Dtur_1158"/>
    <dbReference type="EnsemblBacteria" id="ACK42437">
        <property type="protein sequence ID" value="ACK42437"/>
        <property type="gene ID" value="Dtur_1158"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1158"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1195"/>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027486_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2T7"/>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000118605" description="4-hydroxy-3-methylbut-2-enyl diphosphate reductase">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <sequence length="283" mass="31885" checksum="50AD7454E571C21D" modified="2009-03-03" version="1">MKVYIATPYGFCSGVKKSISLAEKILSLKGEVYTLGALVHNPKVIEELSKKGIKVLGKDEIVEGKALIVRAHGLPQRDIDFYKSLGNEIYDATCPLVKKVQVLAEYLKNNKYKVIIIGEKNHPEVIGILSYTDNQGIVIEYESDIEKVEYYPKIGIVFQTTQSFDNAIQKVNLIMNKGKEIRIFNTICPETIERQEKAKKLSKIVDVALVLGGKNSANTRRLYITLSLKVPTYHIENLEEIDKNWFKEDSKVGIITGTSTPNNFVEEVLALLKSLYPLEIHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2W0</accession>
    <name>B8E2W0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583542.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353074.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1181"/>
    <dbReference type="EnsemblBacteria" id="ACK42460">
        <property type="protein sequence ID" value="ACK42460"/>
        <property type="gene ID" value="Dtur_1181"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1181"/>
    <dbReference type="HOGENOM" id="CLU_2552834_0_0_0"/>
    <dbReference type="OMA" id="YTSPKEM"/>
    <dbReference type="OrthoDB" id="2206487at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="82" mass="9561" checksum="FE62B32E466F064B" modified="2009-03-03" version="1">MEIKNIDKVLLIISIAIFIVILIFKIFSIRNFNEYTSPKEMKERVEKDINLEIESTVKSTNTLNINNTPEKGPYPPFVEFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2W6</accession>
    <name>B8E2W6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_1187</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583548.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353080.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1187"/>
    <dbReference type="EnsemblBacteria" id="ACK42466">
        <property type="protein sequence ID" value="ACK42466"/>
        <property type="gene ID" value="Dtur_1187"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1187"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1224"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_0"/>
    <dbReference type="InParanoid" id="B8E2W6"/>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="193"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="385"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="557" mass="61376" checksum="B3EC17406F5177DE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Y1</accession>
    <name>EFTS_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor Ts</fullName>
            <shortName evidence="1">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsf</name>
        <name type="ordered locus">Dtur_1202</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583563.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353095.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2Y1"/>
    <dbReference type="SMR" id="B8E2Y1"/>
    <dbReference type="STRING" id="515635.Dtur_1202"/>
    <dbReference type="EnsemblBacteria" id="ACK42481">
        <property type="protein sequence ID" value="ACK42481"/>
        <property type="gene ID" value="Dtur_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1202"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1240"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2Y1"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000116727" description="Elongation factor Ts">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <sequence length="198" mass="22482" checksum="4C25B6E3316A015A" modified="2009-03-03" version="1">MEITIEMIKELRERTGAGVMEAKKALEEANGDMEKAVTILREKGVIKAAKKAGRVAKEGIIEAYIHTGDKLGVLVEINCETDFVARTDEFRKLAKDIALQIAGMNPQYVSKEDVPPEVIEKEKEIYRTQLRNEGKPEHVIEKIIEGKLEKFYEEVCLLEQPFVRNPEIKVKDLITEAISKLGENIVVRRFARFVVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Y3</accession>
    <name>B8E2Y3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583565.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353097.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1204"/>
    <dbReference type="EnsemblBacteria" id="ACK42483">
        <property type="protein sequence ID" value="ACK42483"/>
        <property type="gene ID" value="Dtur_1204"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1204"/>
    <dbReference type="HOGENOM" id="CLU_2329258_0_0_0"/>
    <dbReference type="OMA" id="IELYEVP"/>
    <dbReference type="OrthoDB" id="2138923at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="98" mass="11464" checksum="94B9DFFFA5CF5A46" modified="2009-03-03" version="1">MTNFPIYVVYVWKKDDSIDKLDLPIIAIGNPREILLLCQRILAPKSTITEFFQEYKSYAQKMGYDTHNLELLSFLKLLSKMKIIELYEVPKEIFSSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Z2</accession>
    <name>B8E2Z2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytidylate kinase</fullName>
            <shortName evidence="16">CK</shortName>
            <ecNumber evidence="16">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytidine monophosphate kinase</fullName>
            <shortName evidence="16">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">cmk</name>
        <name evidence="19" type="ordered locus">Dtur_1213</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 16">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RibF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 16">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="16"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583574.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353106.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1213"/>
    <dbReference type="EnsemblBacteria" id="ACK42492">
        <property type="protein sequence ID" value="ACK42492"/>
        <property type="gene ID" value="Dtur_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1213"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516524_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2Z2"/>
    <dbReference type="OMA" id="SMIRTEE"/>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006771">
        <property type="term" value="P:riboflavin metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="18">
        <location>
            <begin position="184"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="286"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="321"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00010214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ACK42492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="529" mass="60548" checksum="3C9D1D9A6E1A3D55" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E313</accession>
    <name>B8E313_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583595.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353127.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1235"/>
    <dbReference type="EnsemblBacteria" id="ACK42513">
        <property type="protein sequence ID" value="ACK42513"/>
        <property type="gene ID" value="Dtur_1235"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1235"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1275"/>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031277_2_0_0"/>
    <dbReference type="InParanoid" id="B8E313"/>
    <dbReference type="OMA" id="LMFLCPM"/>
    <dbReference type="OrthoDB" id="591335at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="406" mass="48543" checksum="983999489194D682" modified="2009-03-03" version="1">MVNVYPFTAFRFNSELPINDLISPPYDVIPKEDREKYLKKHRYNITHLTLGDSSPIDYREIKNLFLKWIDSHILVSESPGFYLYKQEFQWGDRDEYNYSIIVLLELEPLGENILPHEHTFSGPKLDRLELLRNLRANLEPIWGIYEDKSSMLRSIWIEIEKEEPMIKAHSWDNRNHLIWKIEKAEHVNLIMNFFVDKKILIADGHHRYEASWLYYSEVKDPNAKYIMILMTDLYDPGIKLLPTHRILKDIEIEINDLRRYFDLYLEDNKIENLDLLFRPNNPYIYYVVNNKIFRLVPKINYMKENKEHSELWWVLPTTLLHKGIWEGTLGKTENELQERGLVRFSHDIKEVKSLLYSGTYRSAFVLPSIPIEMVYTLAINRERLPQKSTYFYPKPVSGLILWKMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E336</accession>
    <name>B8E336_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Formate--tetrahydrofolate ligase</fullName>
            <ecNumber evidence="6">6.3.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Formyltetrahydrofolate synthetase</fullName>
            <shortName evidence="6">FHS</shortName>
            <shortName evidence="6">FTHFS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fhs</name>
        <name evidence="7" type="ordered locus">Dtur_1637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.3" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583985.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353524.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1637"/>
    <dbReference type="EnsemblBacteria" id="ACK42910">
        <property type="protein sequence ID" value="ACK42910"/>
        <property type="gene ID" value="Dtur_1637"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1637"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1686"/>
    <dbReference type="eggNOG" id="COG2759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003601_3_3_0"/>
    <dbReference type="InParanoid" id="B8E336"/>
    <dbReference type="OMA" id="CGEIMTM"/>
    <dbReference type="OrthoDB" id="177859at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="53"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="544" mass="59821" checksum="87EFDBED5731F3D0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E370</accession>
    <name>B8E370_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PP-loop domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584019.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353558.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1672"/>
    <dbReference type="EnsemblBacteria" id="ACK42944">
        <property type="protein sequence ID" value="ACK42944"/>
        <property type="gene ID" value="Dtur_1672"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1672"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1722"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_1_1_0"/>
    <dbReference type="InParanoid" id="B8E370"/>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="OrthoDB" id="1051352at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP_bind_3" evidence="2">
        <location>
            <begin position="49"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="318" mass="36562" checksum="F9F12F2ADB1BFC05" modified="2009-03-03" version="1">MHCTKCHNEASIYIRRHNTAFCKEHFIEYIYGQVEKAIKKYKMFEKNDQILVAVSGGKDSLALWDILISLGYKADGLHIDLGISEYSEKSKETVKKFAESKNLKLHIISIKDLYGLGIKEIAHKNRKTPCATCGVIKRYIMNLAALELKYNVIATGHNLDDESATLLGNILHWQIDYLKAHSPILLEDEVGFARKVKPLYRVSEYETSAYCIMKKIEYIIDECPMSIDAQSLKYKEILNIIERDSPGTKEQFYFGFLEKGKIYFSPEKRDIKLNNCKICGQPTTSEICGFCRQMTKANLEPLRIKEFVIKLKDSYGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E381</accession>
    <name>B8E381_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1683</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584030.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353569.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1683"/>
    <dbReference type="EnsemblBacteria" id="ACK42955">
        <property type="protein sequence ID" value="ACK42955"/>
        <property type="gene ID" value="Dtur_1683"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1683"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_3_0_0"/>
    <dbReference type="InParanoid" id="B8E381"/>
    <dbReference type="OMA" id="RIDLMAY"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010043">
        <property type="term" value="P:response to zinc ion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="265" mass="29581" checksum="071B5E647F4908BC" modified="2009-03-03" version="1">MEILTYTFTQRALITGVLISILSSIIGIYLIYRGMTFMSAGISHAVFGGLAIGYLLGINMTLTAILFTLFLIWSIPHIVKRSNLKQEIPVGIFYSSSMALGALLLSFHKGYTTDLFSFLFGSILSVKEEDIILTLLLTAITLIFFVKNYWKIIFILFDKETAEASGIKVFKIERWILMLTGISIVLISKLVGIILSSALIIIPAATIIPFVKDIKKSILFTILLNLIFITLGLILSYYFNIPTGSTIVMIATTFFLISLFIKKNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E396</accession>
    <name>B8E396_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anaerobic ribonucleoside-triphosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584045.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353584.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1698"/>
    <dbReference type="EnsemblBacteria" id="ACK42970">
        <property type="protein sequence ID" value="ACK42970"/>
        <property type="gene ID" value="Dtur_1698"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1698"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1749"/>
    <dbReference type="eggNOG" id="COG1328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002707_0_2_0"/>
    <dbReference type="InParanoid" id="B8E396"/>
    <dbReference type="OMA" id="YSYDRVP"/>
    <dbReference type="OrthoDB" id="195920at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031250">
        <property type="term" value="C:anaerobic ribonucleoside-triphosphate reductase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009265">
        <property type="term" value="P:2'-deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01675">
        <property type="entry name" value="RNR_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="627" mass="72043" checksum="68F12F24E75BB950" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3A6</accession>
    <name>B8E3A6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1708</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584055.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353594.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1708"/>
    <dbReference type="EnsemblBacteria" id="ACK42980">
        <property type="protein sequence ID" value="ACK42980"/>
        <property type="gene ID" value="Dtur_1708"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1708"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1759"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="InParanoid" id="B8E3A6"/>
    <dbReference type="OMA" id="MVFVDRW"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="342" mass="38720" checksum="FA0C07E5F0210EFE" modified="2009-03-03" version="1">MRRKENKSPTMKDVAKLAGVSISTVSHVINKTRYVEPETREKVYRAIKTLGYRPNILASSLRKKVTNTIGLIISNITNLFYPEVVRGVEDYLAKYNYNLILCNSDENVEKEKNYIEVLFSRRVDGLIITPSKSSETRENLDLFREKNIPVVLVDRKIEGLEEDVVLADNVGGTYEAINYLISLGHKRIGIITGPLDTTTGYERLEGYFKALEESGINKDDNLIYEGNFKEDGGYKGIEVLLNISNPPTAVFTSNNLMALGALKKITELGLKIPKDLSLISFDDMDWFPYFSPPLTAVYQPAYELGETAVKLLFERLKRGRKKRKEVILPTKLIIRESCAPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3C5</accession>
    <name>B8E3C5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584074.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353613.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1727"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42999">
        <property type="protein sequence ID" value="ACK42999"/>
        <property type="gene ID" value="Dtur_1727"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1727"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055069_1_0_0"/>
    <dbReference type="InParanoid" id="B8E3C5"/>
    <dbReference type="OMA" id="GQVQERK"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="50"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="155"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="389" mass="44938" checksum="2CA1605E79EE77EB" modified="2009-03-03" version="1">MREKITVNIVSEAQAWEVKGQGVYTATLVLTEALKKRSDVEVYLNANGLFDIAHLHTPGPYAISKGLFTGKRLVISAHVVPESVLGSFILSNLWLPLFTSYLIRYYNLADMVIAVSPKVKEELEEIGVKAPIVFIPNPVNLERFYKSQELRIEGRKKLGLSNKDFVVICSGQIQPRKGVDTFLEIAKILPFIKFVWVGGQPFSVLTAGYIEMNEKIKKAPPNVIFTGLVPYEEMPIYLNAADIFFFPSYQENFPMAVLEAASCGLPLLLRDNPEYREPYKDWYIPAKNDEEFKNYILKLHQDISFREEYQKRALRLAKEYSADNVADMMVEVYKEILSKPPRMKRDFLKLEPLREEWRKLFQNLGHKNIHSSPRKRRYLNIKNIQNEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3C8</accession>
    <name>B8E3C8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584077.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353616.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1730"/>
    <dbReference type="EnsemblBacteria" id="ACK43002">
        <property type="protein sequence ID" value="ACK43002"/>
        <property type="gene ID" value="Dtur_1730"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1730"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1782"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="InParanoid" id="B8E3C8"/>
    <dbReference type="OMA" id="ICFIFSW"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="285" mass="31919" checksum="1C4362905C3248A3" modified="2009-03-03" version="1">MRYIKNWKQFQRVLISIFLWIIAAIWYIPIFWMLSTSLKSTQIAITEDPPRLIPKEPTLENYKTVFSAASGISVMRGIINSIIVAVVSTILGLVIATPAAYALSRLNFKGRNAIFWSYVAILAFPGVLFLVPQYFIIHRLGLMDNFLALILPGLGSTFGVFLLRQYMLGIPRELEDAAWIDGCSRLRFLITVVIPYVKPALTTLALMSFLGSWNSFLWPLLVMNSPEKLTLPIALVRFSAGWGDPFRGIGPLMAGAFISVLPTLIIFVVFHKYLMQGISLSVGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYK3</accession>
    <name>B8DYK3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582471.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351999.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0047"/>
    <dbReference type="EnsemblBacteria" id="ACK41385">
        <property type="protein sequence ID" value="ACK41385"/>
        <property type="gene ID" value="Dtur_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0047"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.48"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402647_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYK3"/>
    <dbReference type="OMA" id="QFDAHAW"/>
    <dbReference type="OrthoDB" id="412318at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="458"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="681" mass="80067" checksum="334EB93D2A840E6B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYT2</accession>
    <name>ATPA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpA</name>
        <name type="ordered locus">Dtur_0132</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582549.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352078.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DYT2"/>
    <dbReference type="SMR" id="B8DYT2"/>
    <dbReference type="STRING" id="515635.Dtur_0132"/>
    <dbReference type="EnsemblBacteria" id="ACK41464">
        <property type="protein sequence ID" value="ACK41464"/>
        <property type="gene ID" value="Dtur_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0132"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.137"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_0"/>
    <dbReference type="InParanoid" id="B8DYT2"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000143371" description="ATP synthase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="1">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <sequence length="508" mass="56466" checksum="03CD10E493D85DA1" modified="2009-03-03" version="1">MKEEVLGLPIDKIEKKIKEYDFSPRISNIGYVKHVGDGVAEVSLLNSAFIGEMVVFESGIQGMVLSLKEDSVGVILFGKDEYVKEGDVVYSTSKILQVPTGNGFLGRVIDPLGNPIDGGGLIFPEAYVPIDNEAPSIFDREPVKEPLYTGIRTIDALIPIGHGQRELILGDRQTGKTTIALDTIISQKNYGTICIYVAIAQKRTNIARIVQTLREYGALSNTIVIATFPDEPPALRYIAPMAGCAMGEYFMRQGERVLIVYDDLTKHANTYREVALLLRRVPGREAYPGDIFYLHAHLLERAAKLNKRLGGGALTALPIAETLSGEISTYIPTNLISITDGQIYLDTNLFNAGIRPAINVGLSVSRVGGSAQPKGMRQVAGRLRLDLAQYREYAMFLEFGTELDMATKKKIERGRRVEELLKQGAHEVQPIEEQIISFYLANGGFLDNYPVEKVKDVVIKYIAYLKLKYSSVLTFLREELQLSDQIIYQLHNIFQEFEKEVYANSTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYW0</accession>
    <name>B8DYW0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582577.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352106.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0161"/>
    <dbReference type="EnsemblBacteria" id="ACK41492">
        <property type="protein sequence ID" value="ACK41492"/>
        <property type="gene ID" value="Dtur_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0161"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYW0"/>
    <dbReference type="OMA" id="MLGMRNM"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="110"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="336" mass="37666" checksum="5B91D7EB9EAFAC58" modified="2009-03-03" version="1">MNFLKRYIIPRLIQYFIVIFIGITVVFLVPRLTPLDPVVTVLNRMTAYGAQYLDPSAIEKLKETMMELYGLKGNVLEQYLKFWGRLFKGDFGPSLSIFPTPVISIIMNSLPWTAGLLITVALLSWIIGNILGGLAGYYGDRNWAKILGLLAMTIYPIPYYIMALVLLILFAYVFPLFPMTGGYSVGLTPSFSLEFILNVLKHAFLPALSLILIGIGWWFLSMRSLTSTIVSDDYVVYAQIMGIPSRRILFQYVMRNALLPQITNLALQIGGIFSGSLITETVFSYPGLGQMLYMAINNGDYNLIMGIAVFSIVGIATAALLIDLLYPLFDPRVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYY5</accession>
    <name>B8DYY5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582696.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352225.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0288"/>
    <dbReference type="EnsemblBacteria" id="ACK41611">
        <property type="protein sequence ID" value="ACK41611"/>
        <property type="gene ID" value="Dtur_0288"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0288"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.303"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYY5"/>
    <dbReference type="OMA" id="WEVANVI"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="249" mass="27235" checksum="8AC81B1C7BBCD05F" modified="2009-03-03" version="1">MGKVAIITGGGQGIGKAIAKKFLENGISVVIAEIDEEAGKETEEEYSILGNIKFIKTDVSKEEDVINMVEETAKSFGKINYLINNAGISINKPISELTLEEWNRVLGVNLTGTFLCSKYVYPYMKKEGGVIINIASTRAFMSEPNTEAYSASKGGIYALTHALAISLGPEIRVNCISPGWIETSEWKKKSLRRKPELTELDHKQHPAGRVGKPEDIASLVLFLISDEAGFITGANFIVDGGMTRKMIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYZ9</accession>
    <name>B8DYZ9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TRAP dicarboxylate transporter-DctP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582710.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352239.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0303"/>
    <dbReference type="EnsemblBacteria" id="ACK41625">
        <property type="protein sequence ID" value="ACK41625"/>
        <property type="gene ID" value="Dtur_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0303"/>
    <dbReference type="eggNOG" id="COG1638">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036176_1_1_0"/>
    <dbReference type="InParanoid" id="B8DYZ9"/>
    <dbReference type="OMA" id="FTYKYAN"/>
    <dbReference type="OrthoDB" id="752834at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018389">
        <property type="entry name" value="DctP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038404">
        <property type="entry name" value="TRAP_DctP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33376">
        <property type="entry name" value="PTHR33376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03480">
        <property type="entry name" value="DctP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867581" evidence="2">
        <location>
            <begin position="23"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="325" mass="37109" checksum="629D150F2E6F43CF" modified="2009-03-03" version="1">MKKYFTLLSLLLVVLFISSLSAQSTILIKATSPFPEGHIITQTMVEFKNIIEKETQGRIKFELSIAKDTEEQANERCSKGEVDMQFTGGRAIEVFAPQYFFINAPFVLKDYEHFFRIMKGPIGEKAKSEILKNGNMYTLGYLYRGYRQMTSNKPILGLKDLEGLKLRLPVVPTWIKVWETLGVKAVPVPLTGLYQALKDGTAEASEGDLTQISGYKLYEVQKYLIITNHLVSFGWVHMYKPTFDKLSKADQELFMKTAEKVCNTATMRLLASENDILRLLMENGMTVIYLDAKTMAQIRDKAKPAVEELFRTTWPVTTWEEVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ00</accession>
    <name>B8DZ00_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582711.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352240.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0304"/>
    <dbReference type="EnsemblBacteria" id="ACK41626">
        <property type="protein sequence ID" value="ACK41626"/>
        <property type="gene ID" value="Dtur_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0304"/>
    <dbReference type="HOGENOM" id="CLU_3117226_0_0_0"/>
    <dbReference type="OMA" id="KITLGRV"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="50" mass="5972" checksum="139D4AF87350F60F" modified="2009-03-03" version="1">MKIRLERVKIDQSKIKQIRVNTNRVEEINLKAESVVKDSPIIEYLRTKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ02</accession>
    <name>B8DZ02_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582713.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352242.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0306"/>
    <dbReference type="EnsemblBacteria" id="ACK41628">
        <property type="protein sequence ID" value="ACK41628"/>
        <property type="gene ID" value="Dtur_0306"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0306"/>
    <dbReference type="HOGENOM" id="CLU_1003750_0_0_0"/>
    <dbReference type="OMA" id="DYTFYIN"/>
    <dbReference type="OrthoDB" id="2111870at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="273" mass="31020" checksum="50FF39A0DCF96492" modified="2009-03-03" version="1">MRNILKLKKTTIVIIAVFLLFSLYSSKSFGFDWDSFLEGLYRCNITFQRPIYGDTYLYNDPLSTSFTVIDVFGDDYTFYINQNANSSKISYLSLNIRIPFFYTDSLSIGFSNSQRYFYTNIFNETGFSTDSILMANGGGLYLNLKATNQLCIFTVLGAVYYEIDSVADTLKPSWYGDPGLYWNGYFYEPGTPLKVKGQTDYMFFFSVGIKYYLLSGLYLELCYSNFPGATIKNMSYILEGPTDLKINVSSDKMPKPITIKESSIITFGIGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ05</accession>
    <name>B8DZ05_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582716.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352245.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0309"/>
    <dbReference type="EnsemblBacteria" id="ACK41631">
        <property type="protein sequence ID" value="ACK41631"/>
        <property type="gene ID" value="Dtur_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0309"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587584_0_0_0"/>
    <dbReference type="OrthoDB" id="1143375at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="480" mass="56933" checksum="39414F7F3A688458" modified="2009-03-03" version="1">MSLKGDLESIPLWEVFQLISSGKKNGKFQIDYKDNYGEIYFKDGRIVYAKTNTLEHIDAIVDILLWSKGTFTFIPDTNPPKLSINLDPLEILLTTDKNLDEYHYFANLILIPINPQNLSKEEETLINLFDGKKYVKDVIDETNLSKIKALNIIKDLLKNKKLIKINNDPNIFWFYIFWRTWNYLLEEYSKLGISERQFKTHFRKILDNHKSKLKNIFEDLVFPPTLSPLYFYQYLKEENGPTQEDVQKIYEDITTSEKINWNDIFNNLNEFSPSAVKQFVSECIDHLYSLGKTSIDKYLNNANVERYKLLIEEKQKDPFIYIGEKKFFEEEILSWYLDGTANISEILEYPIWGKERTILLLGTLLENGKIISLIEDKKLKIIYNFGKLWDKIKKEYKSKKFYQEIYEKISELLEESAQDTKYVLEKIVNDYSENWIYVYQKLKLTEESEVRVFVDSVLNIISETEDEKIKEIIKNFKLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ21</accession>
    <name>B8DZ21_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin/nitric oxide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582732.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352261.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0330"/>
    <dbReference type="EnsemblBacteria" id="ACK41647">
        <property type="protein sequence ID" value="ACK41647"/>
        <property type="gene ID" value="Dtur_0330"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0330"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.351"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZ21"/>
    <dbReference type="OMA" id="CTTATVH"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="168" mass="17988" checksum="30906F82AD5E428B" modified="2009-03-03" version="1">MAKVLILYDSATGNTKKMAEEVAKGVQEVEGVEVVIKHVDDAIPEDLLNFDGIIVGSPAYCGTLTWKLKKFFDESVSVAWGKVKGKIGAAFSSSGGLGGGNEATLYSILTVLMNYGYLVFGLPDYSAPGVTAHYGAVSVGYPKEAEQKACRMLGRQMAEYVKKFCKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ29</accession>
    <name>B8DZ29_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PUA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582740.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352269.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0341"/>
    <dbReference type="EnsemblBacteria" id="ACK41655">
        <property type="protein sequence ID" value="ACK41655"/>
        <property type="gene ID" value="Dtur_0341"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0341"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.361"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ29"/>
    <dbReference type="OMA" id="VMDVFDY"/>
    <dbReference type="OrthoDB" id="468283at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="395" mass="45164" checksum="665474F4D59E2445" modified="2009-03-03" version="1">MLERARVILKKGVHTKVVRGNPWIYDNEILKIEGDFLPGDVVDIYDVSKSFIGRGFINPNSKIRIRILTRKEEEIDKEFFRERILKAWEYRKKVVDTDSCRVVFAEADFLPGLIVDKFSDILVIQTLTLGIDRFKEVIVEVLDEIFQPKGIYERNDVSVRELEGLPQVKGFLKGNFDTKVEIVENGIKVIVDVENGQKTGYFLDQRENRASLRGLVDGAEVLDVFCYTGGFSLHALKYGASKVVAVDSSGIALEIAKENAKLNGFMDRIEFIEENAFDLLRRFHKEGRSFDVVILDPPAFAKSSKNIDGALRGYKEINLRAMKIVRDGGFLITCSCSQHITRDLFEKVIESASFDANRLLRLVEFRYQAKDHPILLSHPESLYLKCGIYQVWKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ58</accession>
    <name>B8DZ58_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352298.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0380"/>
    <dbReference type="EnsemblBacteria" id="ACK41684">
        <property type="protein sequence ID" value="ACK41684"/>
        <property type="gene ID" value="Dtur_0380"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0380"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_3_1_0"/>
    <dbReference type="OMA" id="LATVDHW"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH deoR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="254" mass="28827" checksum="42317DD9A0AD0A89" modified="2009-03-03" version="1">MKMKEYRFERILQLIREKGYLTVQEIAKELSISEITVRRDLNFLEKQGLIKRVRGGATATSISSENSFFLKLEENKEIKKEIGKKALSLLKDGSIIAMSGGTTIYYMVQALDQSPITNLTILTNSITTAWAVINLRKNFRLIHSGGTTKEKSFECIGGHVIKFFQEIGKIDYYFFGANGVDIKNGITFFDMEEAEVAKTIISKAEKKVLVADSSKFNLSVPFKVCDFDDLDYIVSDSIPEEFKKIPEWSQKFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ66</accession>
    <name>B8DZ66_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0388</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582777.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352306.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0388"/>
    <dbReference type="EnsemblBacteria" id="ACK41692">
        <property type="protein sequence ID" value="ACK41692"/>
        <property type="gene ID" value="Dtur_0388"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0388"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_0_0"/>
    <dbReference type="InParanoid" id="B8DZ66"/>
    <dbReference type="OMA" id="MAMFYAN"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="7"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="299" mass="32993" checksum="5347E859C4C8D209" modified="2009-03-03" version="1">MELDVLTIGEILVEIMAKKIDQDFLHPGEFLGPYPSGAPAIFIDQIVKLGLKGGILGCIGEDDFGRNVFERLKKDGVEVGLIKKTQEYITGIAFVTYFSNGERKFIFHLPHSAASCIYPEDITEDLIKNIKALHIMGCSLAIKDNVKEAIHKAVNLAYEYGKLISFDPNIRVELGLSKEYLETIKNIASKSKIILSGERELSIIGEVNKEEKIIVIKKGKHGAEAYYKDKVYKVAPIEVEEVDPTGAGDCFDAGFVASILQGYTIEDALKRANIIGALSVTKRGPMEGVVDKKTLDMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ75</accession>
    <name>B8DZ75_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Dtur_0515</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582893.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352422.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0515"/>
    <dbReference type="EnsemblBacteria" id="ACK41808">
        <property type="protein sequence ID" value="ACK41808"/>
        <property type="gene ID" value="Dtur_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0515"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.546"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_0"/>
    <dbReference type="InParanoid" id="B8DZ75"/>
    <dbReference type="OMA" id="DAKYGEW"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="4"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="340"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="438"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="141"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="41"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACK41808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="463" mass="49954" checksum="5B6089357A29B529" modified="2009-03-03" version="1">MEKFDVIFLGAGSGGYVGAIRAADLGKKVCIIEARELGGTCLNRGCIPTKALLKSAEVFRTVKEAKTFGVNVDSYSFDVNGIYSWKENVVKKLVSGVEYLLKSRKVVIKKGRGRIIDNETVEIETSEGKEIVQGENIVIATGSEPAMIPTFKIDGKNVLTSDDALTLGEIPKDIVIIGAGAIGIEFATFYSTFGTKVTIVEMMPQVVPTLKDKKVANYLQRILNKKGIEVKVGAKIESVEVKDGKVYSTLSTGEVLESEKVLVSIGRKLNSDNIGLENIGVNVDRGRIVVDEYLRTNVKNVYAIGDVIGGLLLAHKAMKEGEVVAEIIAGENKKMDYRVVPWAIFSSPEIAACGLTEEEAKEQGIDVITGEFPFSANGKAVSMNATDGFVKVVARKEDKVIIGAQIIGPEASVMIAELALAIQNNLTLDDVADTIHTHPTLPEAIMEAVKVPLGSVVHIYLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZD9</accession>
    <name>B8DZD9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582957.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352486.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0584"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41872">
        <property type="protein sequence ID" value="ACK41872"/>
        <property type="gene ID" value="Dtur_0584"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0584"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.619"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_36_1_0"/>
    <dbReference type="InParanoid" id="B8DZD9"/>
    <dbReference type="OMA" id="YHFHDPE"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="184"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="373" mass="42861" checksum="1A823DA371ECF279" modified="2009-03-03" version="1">MKAKVCHITTVHSPFDVRIFHKECKTLAKSGYEVYLIAQHDKEEIVDGIHLIPLPIVRSRIRRMIYLPIRALKEALKLKANIYHFHDPELIPIGVLLKVFAKGKVIYDVHEDVPKQIMSKYWIPKKLRGIISFIVNLGEKKFSFLFDAIITATDDILKNFSFYRNAISIKNYPMLSKFLEVKGKEKKDDVFKIIYIGGLSKIRGISEVVKALEYVDSNKEVRLILCGKFSPIEYEKEVRNLKGFEKVDYLGWLEPDEVVNKLVDVDAGIVCLHPITNYVTALPVKLFEYMAAGLPVIASNFPLWREIVEGNNCGICVDPLNPKEIAEAIKYLIEHLDKAQKMGENGKKAVLEKYNWEKESEKLIKLYEDLLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZE0</accession>
    <name>B8DZE0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582958.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352487.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0585"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41873">
        <property type="protein sequence ID" value="ACK41873"/>
        <property type="gene ID" value="Dtur_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0585"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.620"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_11_2_0"/>
    <dbReference type="InParanoid" id="B8DZE0"/>
    <dbReference type="OMA" id="GNMGRCH"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="25"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="225"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="415" mass="47707" checksum="1E198ECDB53C786C" modified="2009-03-03" version="1">MANKNIWLFNHYAITPNLPGGTRHFDFGKELVRRGYKVTIFASSFHYSLLRETKEYEKEKFIIEDYEGVRFVWLKTFSYSGNDWRRVVNMLSYAIRAYEVAQKINTEKPDIIIGSSVHLFAVFTAYLLSKKYKTPFIMEVRDLWPQTLMDMGVSKWHPFVILLGILEKFLYKRADKIIVLLPRANEYIEKLGISPEKIVWIPNGVDFERFQFKNGGSLRDETYTSDEFIVTYTGAIGKANNLDVAVEAAKILQKDYPNIKFLFVGDGPEKGRLLEIVKKEKINNLEFKAPLPKDRIVEIIQKADVLFLALKDSPLYKYGISLNKLFDYLASGKPIIFSSNSINNPVDEAKAGITVPPDNPQALADAIIKLYKMSPEERRAMGLNGRKYVEKYHSIPVLVDKLEKIFEEVGVMKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZG0</accession>
    <name>B8DZG0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ARMT1-like_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582978.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352507.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0605"/>
    <dbReference type="EnsemblBacteria" id="ACK41893">
        <property type="protein sequence ID" value="ACK41893"/>
        <property type="gene ID" value="Dtur_0605"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0605"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.642"/>
    <dbReference type="eggNOG" id="COG1578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071520_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZG0"/>
    <dbReference type="OMA" id="FLLKAKC"/>
    <dbReference type="OrthoDB" id="1714760at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014444">
        <property type="entry name" value="PH1575-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006593">
        <property type="entry name" value="UCP006593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="SSF111321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARMT1-like_dom" evidence="1">
        <location>
            <begin position="6"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="290" mass="32948" checksum="27F31443B9CCB579" modified="2009-03-03" version="1">MKTRWECYTCFFRQAESALKRINIPNEKKIEIIKEIAKDLEKLSPEDTPSYNTYFIFKKIYELSGVEDPYFEEKKYYNQQGLKLYEALRNIVLSSEDPLYTAIKVAIAGNVIDLGILNISKLNLGEYIKEIINIPLAIDHYFYFKNELSKTNEILYLLDNAGEIVFDKILIEELSKEKEVIAVVNENPVINDALMEDAIEVGLNKCAKIITTGSGSVGKPPELGGEEYQKTFNSAKLIISKGQANYESLEGRGYNIFFLLKAKCEVVAENLGVKEGDLVFLYEKAKNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZG8</accession>
    <name>B8DZG8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, Csx3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352515.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0613"/>
    <dbReference type="EnsemblBacteria" id="ACK41901">
        <property type="protein sequence ID" value="ACK41901"/>
        <property type="gene ID" value="Dtur_0613"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0613"/>
    <dbReference type="eggNOG" id="ENOG5032VFT">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172322_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZG8"/>
    <dbReference type="OMA" id="YLIMEVE"/>
    <dbReference type="OrthoDB" id="2013209at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013409">
        <property type="entry name" value="CRISPR-assoc_prot_Csx3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09620">
        <property type="entry name" value="Cas_csx3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02579">
        <property type="entry name" value="cas_csx3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="109" mass="12447" checksum="FA3A05D8BEE0EFD0" modified="2009-03-03" version="1">MLKYLIMEVEDISLEITEKDDYTILYFKLKSNLDPSILKKISPPKINLRRGLIISGRGPIWLYAYLVHYYHPTPFIAIYDPRIGAVVIQSHIKSINVGDVIDISLDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZH8</accession>
    <name>B8DZH8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein, Csh2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582996.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352525.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0623"/>
    <dbReference type="EnsemblBacteria" id="ACK41911">
        <property type="protein sequence ID" value="ACK41911"/>
        <property type="gene ID" value="Dtur_0623"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0623"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.660"/>
    <dbReference type="eggNOG" id="COG3649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071770_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZH8"/>
    <dbReference type="OMA" id="KWGRSLH"/>
    <dbReference type="OrthoDB" id="598606at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013419">
        <property type="entry name" value="CRISPR-assoc_prot_Csh2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02590">
        <property type="entry name" value="cas_Csh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01595">
        <property type="entry name" value="cas_CT1132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="303" mass="34910" checksum="F0026EFFBFA4F7BE" modified="2009-03-03" version="1">MTELKNRSELLFLYDVTDANPNGDPVDENKPRIDEETGVNIVTDVRLKRTIRDYLYEYKGLEVFIREIRKEDGKLKTKEERLEEFKSNQEVIEKCIDIRLFGATTAVEGKTMALTGPVQFKYGRSLHRVDLTYIKGTTVMPSGAEKTQGTFTEKYILPYSLIAFYGIVNDNLAKVQNIPLTQEDVDYMLEAMWHGTKNLISGSKFGQVPRLLIQIVYKPDSYFYIGELNRRIKLISDIEDEKIRDISQVKIDISDLAKALEENKGKIEKIRYKVDERLRLVKDGMDTSLTQALSQLSLEELSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZI6</accession>
    <name>B8DZI6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41919.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352533.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0631"/>
    <dbReference type="EnsemblBacteria" id="ACK41919">
        <property type="protein sequence ID" value="ACK41919"/>
        <property type="gene ID" value="Dtur_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0631"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.668"/>
    <dbReference type="eggNOG" id="COG1725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_10_0_0"/>
    <dbReference type="InParanoid" id="B8DZI6"/>
    <dbReference type="OMA" id="RAYKEME"/>
    <dbReference type="OrthoDB" id="1860081at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="1">
        <location>
            <begin position="37"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="121" mass="13974" checksum="F2FFF020A5721DF6" modified="2009-03-03" version="1">MINFDEEIPIYLQIMDFIKKEVVKGKLKGGDKLPSVRELAEMLKVNPNTVQKAYQELEREGITYTLRGIGSFVTQDGKKIEELKKKMAEDVLERFCKDMRDLGFSDEDIIALLQGYLKEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZJ4</accession>
    <name>B8DZJ4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0642</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583012.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352541.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0642"/>
    <dbReference type="EnsemblBacteria" id="ACK41927">
        <property type="protein sequence ID" value="ACK41927"/>
        <property type="gene ID" value="Dtur_0642"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0642"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.680"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_0"/>
    <dbReference type="InParanoid" id="B8DZJ4"/>
    <dbReference type="OMA" id="KVFSHEP"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="61"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="377"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="410"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="620" mass="70112" checksum="82F5F3323C14A681" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZK5</accession>
    <name>B8DZK5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Permease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="ACK41938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583023.1">
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    </dbReference>
    <dbReference type="RefSeq" id="YP_002352552.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0653"/>
    <dbReference type="EnsemblBacteria" id="ACK41938">
        <property type="protein sequence ID" value="ACK41938"/>
        <property type="gene ID" value="Dtur_0653"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0653"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.691"/>
    <dbReference type="eggNOG" id="ENOG502Z8ST">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_499426_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZK5"/>
    <dbReference type="OMA" id="YPNWIES"/>
    <dbReference type="OrthoDB" id="129991at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="545" mass="63882" checksum="C574D8BCA60C6299" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZK9</accession>
    <name>B8DZK9_DICTD</name>
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        <submittedName>
            <fullName evidence="3">Poly-gamma-glutamic synthesis</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomaceae</taxon>
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    </organism>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0657"/>
    <dbReference type="EnsemblBacteria" id="ACK41942">
        <property type="protein sequence ID" value="ACK41942"/>
        <property type="gene ID" value="Dtur_0657"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0657"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038823_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZK9"/>
    <dbReference type="OMA" id="HFYFMNF"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="2"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="38950" checksum="7B302A3C6BE9D20C" modified="2009-03-03" version="1">MSLSFVGDLFIQRQLFNSYYDPQRKTYYFPEEIFEDIREYINKDFSYIVIDTPVATNLCPPSGYPSYNAPIEILDTLKRVRFNIMITSGNHALDKGERGLIATIENIRKRDLYYVGTNSKKEESKKYLILEKNNIKIGVLAHTFSTNGIPLPKGKEYFVNLIDREKIKKDLSKVKNLCDFKIVYLHWGNIEYLDEVEEWQKRLAKEIINYGADLIVGSHPHAIKTYENIEGKWCFYALGNFFTDQYGVYRPEVKYGYILNLYLLKYKERVNIIKKDIIPIFIWRKSLGSKYEYKLLKAEKVKYLSNIDVKDKIYLKRVKKILRLEEEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZM5</accession>
    <name>B8DZM5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0673</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    <dbReference type="RefSeq" id="YP_002352572.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0673"/>
    <dbReference type="EnsemblBacteria" id="ACK41958">
        <property type="protein sequence ID" value="ACK41958"/>
        <property type="gene ID" value="Dtur_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0673"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="InParanoid" id="B8DZM5"/>
    <dbReference type="OMA" id="FNTLQMG"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="34"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="409"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="441"/>
            <end position="448"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="650" mass="75661" checksum="6F26B99664FB8D22" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZN1</accession>
    <name>B8DZN1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
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                <person name="Gowda K."/>
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            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352578.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0679"/>
    <dbReference type="EnsemblBacteria" id="ACK41964">
        <property type="protein sequence ID" value="ACK41964"/>
        <property type="gene ID" value="Dtur_0679"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0679"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_15_0"/>
    <dbReference type="InParanoid" id="B8DZN1"/>
    <dbReference type="OMA" id="KGMSQGD"/>
    <dbReference type="OrthoDB" id="1342292at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="105" mass="12266" checksum="D5529979C6F61C1A" modified="2009-03-03" version="1">MNVGKRIREIRKKHNMKLEDLAEKTGLSLSYISLIERGLKNPSLKALERIAQALNLPTSYFFSEDNDETIETFLRTKTSLDEDERRMIIQLIKSLEKKKGVRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZQ2</accession>
    <name>B8DZQ2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">L-lactate dehydrogenase</fullName>
            <shortName evidence="6">L-LDH</shortName>
            <ecNumber evidence="4 6">1.1.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ldh</name>
        <name evidence="12" type="ordered locus">Dtur_0700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the conversion of lactate to pyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>(S)-lactate + NAD(+) = H(+) + NADH + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the LDH/MDH superfamily. LDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.27" evidence="4 6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583070.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352599.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0700"/>
    <dbReference type="EnsemblBacteria" id="ACK41985">
        <property type="protein sequence ID" value="ACK41985"/>
        <property type="gene ID" value="Dtur_0700"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0700"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.738"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZQ2"/>
    <dbReference type="OMA" id="CYIIVLT"/>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00488">
        <property type="entry name" value="Lactate_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011304">
        <property type="entry name" value="L-lactate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018177">
        <property type="entry name" value="L-lactate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01771">
        <property type="entry name" value="L-LDH-NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00064">
        <property type="entry name" value="L_LDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="11">
        <location>
            <begin position="143"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="118"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="146"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="116"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine" evidence="6">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK41985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="318" mass="35091" checksum="F32DE58B1D56A490" modified="2009-03-03" version="1">MKKVLIVGAGAVGTSFAYSLIHKGLIEEIVLYDIDEKRAIGEALDLAHGIYFTKPVEIRAGDLKEAKDSDMVVITAGAKQKPGETRLQLLDRNINIYRSLIPEIVQSGFNGIFLIVTNPVDVLTYFTYKFSGFSRNKVIGSGTVLDSSRFAYLLSRHCDVDPRSVNAYVIGEHGDTAVLAWSLTHIGGISLSEFCPVCGKRCFEDNVKEAIIKEVRNSAYKIIEYKGATYYAIGLALVNIVEAIARDENRILPVSIVHPEIFGFKDIPLSLPSIVGRNGVKKVLQVKLSEEEERELYKSAKLIKEVIDSFSSLSLSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZR8</accession>
    <name>B8DZR8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RfaE bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583086.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352615.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0716"/>
    <dbReference type="EnsemblBacteria" id="ACK42001">
        <property type="protein sequence ID" value="ACK42001"/>
        <property type="gene ID" value="Dtur_0716"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0716"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.753"/>
    <dbReference type="eggNOG" id="COG2870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021150_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZR8"/>
    <dbReference type="OMA" id="CEFANAA"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033785">
        <property type="term" value="F:heptose 7-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033786">
        <property type="term" value="F:heptose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02198">
        <property type="entry name" value="rfaE_dom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="17"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="333" mass="37237" checksum="3683014FF865C85D" modified="2009-03-03" version="1">MDIRERLIRIINSWKGKKIAVIGDIMIDEYIIGKIERISPEAPVPVLEIEEEKYVLGGAGNVANNIKALGGEPLLFGVVGEDIGAEKILNLLNQREIKNFLVKDKERPTTTKTRLIALSQQVVRMDKEKRNPIKEEIEMLLLEKIKENIEKIDIFLLSDYAKGVLTYSFTKKIIELAKTYGKKILVDPKGKDFTKYKGASYITPNEKEAKIATDMEENFDIIICAQKLLELIEGEGVIITRGEKGMFLYLKDSYYFIPALKAEVRDVTGAGDTVISALTLAISSDANPLEAALISNFAGSVVVRKLGTSTLSPEEIIQVIPQKINIDKNYVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZS2</accession>
    <name>B8DZS2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogen-fixing NifU domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583090.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352619.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0720"/>
    <dbReference type="EnsemblBacteria" id="ACK42005">
        <property type="protein sequence ID" value="ACK42005"/>
        <property type="gene ID" value="Dtur_0720"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0720"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.757"/>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302638_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZS2"/>
    <dbReference type="OMA" id="LKHVMNP"/>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="FeS_assembly_P" evidence="2">
        <location>
            <begin position="132"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="207" mass="22855" checksum="D07FC17649739302" modified="2009-03-03" version="1">MLRYTDIVLEHFKNPRNVGVIEDPDGYAIEGSPACGDQIVVYIKVDPNTKVITDIKFQSFGCASNIATGSMMTEMVKGKTIEEALKLTWKDVVDALGGLPPVKLHCSVLAIDGLKAAIRNYLGEKTEGKLSKEEVVNVLSNVLYPSLAVDIVTLKLLNFLKITEKGKVIIELLLGEEDPFKEHIKEEIVEKLSKINGVKEVEVNFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZT3</accession>
    <name>B8DZT3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin, iron-sulphur binding, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583101.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352630.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0733"/>
    <dbReference type="EnsemblBacteria" id="ACK42016">
        <property type="protein sequence ID" value="ACK42016"/>
        <property type="gene ID" value="Dtur_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0733"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152999_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZT3"/>
    <dbReference type="OMA" id="TGVCPTE"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018449">
        <property type="entry name" value="NIL_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09383">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00930">
        <property type="entry name" value="NIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="137" mass="15545" checksum="DD0FB50938C88093" modified="2009-03-03" version="1">MRTERIVLHFPKELADKPIIVNLVKKFDLDFNILKATITPDAEGVMVLEISGEDDNFLKGIEYLKDLGVSIQPLSKDVIWLEEKCVHCGYCVSYCPTKALYRNEKTLMVGFDSQKCTACGVCIEICPYNAMEMKIFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZV7</accession>
    <name>B8DZV7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FolC bifunctional protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0758</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352654.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0758"/>
    <dbReference type="EnsemblBacteria" id="ACK42040">
        <property type="protein sequence ID" value="ACK42040"/>
        <property type="gene ID" value="Dtur_0758"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0758"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.796"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZV7"/>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="6">
        <location>
            <begin position="54"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="5">
        <location>
            <begin position="305"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="443" mass="50807" checksum="6B283C19785A4E6E" modified="2009-03-03" version="1">MSYFERLNYLNSFINYEKRLDNITYEEKKFYLERMRYLLKLMGNPQDNLQAFHVAGTKGKGSTSAMIFSILKEAGYKVGLYTSPHLQSIRERISTHKGFISQEEFIDLIDYAKPYIEEAKKHPIFGPPTFFEVLTALAFLYFYIKKLDYVVIEVGLGGRLDATNVINPLVSIITPIGFDHMHILGNTIEKIAFEKAGIIKEGKFVISSIQKEEAEKVIAKVAKERNAIYYKIDNLFKWERKDFSLNGQRFLLSGKDINEEFFIPLLGEHQIVNAITAFGAIYLLRDKLSIDYETVREGFKKVQWMGRFQIVSKSPLTIIDGAHNVESAIALRDTLKNYVNFNRLFLICGLMKDKDAEGFLKILNPLVYSYNFVPLSSHRTRSPEELGNIVKSFNADANINLHTNFYEAINFVKKEASPEDLILITGSLYLAGEALNYFYGNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZZ3</accession>
    <name>B8DZZ3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583161.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352690.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0795"/>
    <dbReference type="EnsemblBacteria" id="ACK42076">
        <property type="protein sequence ID" value="ACK42076"/>
        <property type="gene ID" value="Dtur_0795"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0795"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.833"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_6_2_0"/>
    <dbReference type="InParanoid" id="B8DZZ3"/>
    <dbReference type="OMA" id="NWRPTFW"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="315" mass="35527" checksum="7C40224DE86E7D7B" modified="2009-03-03" version="1">MILACGEALIDFTPIEINKEVAYVPKEGGSPYNVAITLGRLGTLCGFFGKISKDFFGEMLIEKLRNNHVDTSFVLRSEKSTTLAFVILKEGEPHFVFYGENTADTSLEEKDMPYIDPEKIKLIHFGSISMIREPGCFVLEKMMSQNHGKVSISFDPNVRSNLIKDKVNYLKKFETWIGYVDILKASIADLTWLYETEDTDELAKYFLRRGVKIFLVTLGKEGSKGYTKFFSAFSKGKEVKVADTVGAGDAFMGGFLYYLNSIGKLNKNFLESITKEELENALDFSNTVSALTCTKKGAEPPYLSEVENFMLKRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E002</accession>
    <name>B8E002_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583169.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352699.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0804"/>
    <dbReference type="EnsemblBacteria" id="ACK42085">
        <property type="protein sequence ID" value="ACK42085"/>
        <property type="gene ID" value="Dtur_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0804"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.842"/>
    <dbReference type="eggNOG" id="COG3872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038140_0_0_0"/>
    <dbReference type="InParanoid" id="B8E002"/>
    <dbReference type="OMA" id="LFQYHGA"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010787">
        <property type="entry name" value="DUF1385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07136">
        <property type="entry name" value="DUF1385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="294" mass="34072" checksum="83B07CB51CCD41B6" modified="2009-03-03" version="1">MKNKKDLVGGQAVYEGVMMRKGIDIAVAVRDPDGQIVVKKERLQPYFKKWTQIPFLRGLMILMDSLFWGIKALNYSTQVAFKEDEKIDSNWEIGLALLLGFVFFVIIFIVLPLLVVKPIEKHISSQIIIRLLEGIVRLVIFVFYLFSITKIKEIYRVFQYHGAEHKTVFCYEAGEELTVENCRKYSRFHPRCGTSFLLVVMIVSIVIFAFLGQQTFLLRIISRILLIPVIFSLSYEIIRLGSQHTDSWFWKIVLTPGLWMQYFTTKEPDDSQLETAIVALKEVTKEDYASEVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E015</accession>
    <name>B8E015_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane chaperone Skp (OmpH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583182.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352712.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0817"/>
    <dbReference type="EnsemblBacteria" id="ACK42098">
        <property type="protein sequence ID" value="ACK42098"/>
        <property type="gene ID" value="Dtur_0817"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0817"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1692712_0_0_0"/>
    <dbReference type="OMA" id="PKIAYID"/>
    <dbReference type="OrthoDB" id="2116720at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061077">
        <property type="term" value="P:chaperone-mediated protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032978">
        <property type="term" value="P:protein insertion into membrane from inner side"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022417">
        <property type="term" value="P:protein maturation by protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="155" mass="17516" checksum="05574DAB03A664D7" modified="2009-03-03" version="1">MKKYGILALVLLVSVAFIFVGLKIVGAQTPQPKIAYIDEDKLLRNYPPFMSAYNKYQQEYQDRLNKISEAQKAGKSQDEIKKLSDQYDKELEPYKQAVQKVLENLRKTLDGIFADLSKKEGYIAVLTKSVQGQDIVIWGGVDITDKVIKILSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E016</accession>
    <name>B8E016_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane chaperone Skp (OmpH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583183.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352713.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0818"/>
    <dbReference type="EnsemblBacteria" id="ACK42099">
        <property type="protein sequence ID" value="ACK42099"/>
        <property type="gene ID" value="Dtur_0818"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0818"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128691_1_0_0"/>
    <dbReference type="OMA" id="WGGIDIT"/>
    <dbReference type="OrthoDB" id="1988474at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="139" mass="16435" checksum="BD39283B97892CBD" modified="2009-03-03" version="1">MRIKWFLISILALIFTFNVISSTQTLNVGVLDYSKVFLEYKETKTVQNEIKKRQELIQKMVEDYKKKGMNDKQINELRAKEEKKLGDFVEEARIRIRERIYKEVEKVAKAKNLSVVLEKRIKIWGGIDITTEVLNNLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E056</accession>
    <name>B8E056_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-phytase</fullName>
            <ecNumber evidence="3">3.1.3.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.26" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583223.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352753.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0858"/>
    <dbReference type="EnsemblBacteria" id="ACK42139">
        <property type="protein sequence ID" value="ACK42139"/>
        <property type="gene ID" value="Dtur_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0858"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.897"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_7_0_0"/>
    <dbReference type="InParanoid" id="B8E056"/>
    <dbReference type="OMA" id="YDFFTWE"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008707">
        <property type="term" value="F:4-phytase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867727" evidence="1">
        <location>
            <begin position="21"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="70"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="524" mass="59604" checksum="66BD40975A50B781" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E057</accession>
    <name>B8E057_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583224.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352754.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0859"/>
    <dbReference type="EnsemblBacteria" id="ACK42140">
        <property type="protein sequence ID" value="ACK42140"/>
        <property type="gene ID" value="Dtur_0859"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0859"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.898"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_0"/>
    <dbReference type="InParanoid" id="B8E057"/>
    <dbReference type="OMA" id="AAWKHGT"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="333" mass="37797" checksum="DE335A986AA58F08" modified="2009-03-03" version="1">MREYIIKRLLLLIPIVIGVSFFSFILIRLIPGDPARIILGERATPQELERIREELGLNKPILVQYLIFLKQIAKGDLGRSIITREKVIKEIMNRFPATIELTFFSMFIAVFFGIFFGILASLKPGSFIDSFVMFLALIGVSMPIFWLGLMLIWFGSLYLGWFPPSGRLDVDINLNVITNFYLVDSILTGNFKAFFNSLYHLILPSIALSSVPMATIARMTRSSMLEVLNQEYILAEYAKGLPKRKIILRSALRNALIPIITVIGLEFGFLLGGAIMTETIFSWPGMGRLVYDAIMSRDYPLIQGAILLSAFLFVMINLVVDVIYVFIDPRIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E079</accession>
    <name>B8E079_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNA repair protein RadC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0758 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583246.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352776.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0881"/>
    <dbReference type="EnsemblBacteria" id="ACK42162">
        <property type="protein sequence ID" value="ACK42162"/>
        <property type="gene ID" value="Dtur_0881"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0881"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.919"/>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073529_0_2_0"/>
    <dbReference type="InParanoid" id="B8E079"/>
    <dbReference type="OMA" id="AMPDYEL"/>
    <dbReference type="OrthoDB" id="1833204at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08071">
        <property type="entry name" value="MPN_DUF2466"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001405">
        <property type="entry name" value="UPF0758"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30471">
        <property type="entry name" value="PTHR30471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00608">
        <property type="entry name" value="radc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="106"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="228" mass="26203" checksum="324600372CF69997" modified="2009-03-03" version="1">MKKRKIKDFPKSERPRERLLNYGEKALSDAELLAIILRTGNKNYSVYELAQNLIVDFGSLKRIAEVGIGELIKYPGIGITKAVQIKASIELGRRIFSEKKNYFGESILNPHDAFLIFKEDMFDLKEEHLFCIYMDVKNKCLNKRLIAKGDLNIVYASPREIFKYALQENSSKLILAHNHPSGDLTPSEDDIIFTKRLIEAGKILGLEILDHLIIYNEDYVSLKEKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8E082</accession>
    <name>B8E082_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13 14">UvrABC system protein B</fullName>
            <shortName evidence="13">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">uvrB</name>
        <name evidence="19" type="ordered locus">Dtur_0884</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 13 14">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583249.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352779.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0884"/>
    <dbReference type="EnsemblBacteria" id="ACK42165">
        <property type="protein sequence ID" value="ACK42165"/>
        <property type="gene ID" value="Dtur_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0884"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.922"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_0"/>
    <dbReference type="InParanoid" id="B8E082"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13 14" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 13 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 13 14" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 14" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="25"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="428"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="620"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="609"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="13">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ACK42165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="662" mass="76428" checksum="AE8583A42AC5A737" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0H2</accession>
    <name>B8E0H2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583698.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353231.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1343"/>
    <dbReference type="EnsemblBacteria" id="ACK42617">
        <property type="protein sequence ID" value="ACK42617"/>
        <property type="gene ID" value="Dtur_1343"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1343"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1388"/>
    <dbReference type="eggNOG" id="COG1574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028036_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0H2"/>
    <dbReference type="OMA" id="DPGPYYL"/>
    <dbReference type="OrthoDB" id="361195at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="445" mass="49816" checksum="B76DA1BCD0BB3D17" modified="2009-03-03" version="1">MLKIFSPTAILGYGFPEKTYYNALSEKPDIIAVDAGSTDPGPYYLGKGISFVDRNATKRDLYYLIKMALKFDIPILVGSSGGCGTKSSLDWTFDIVKEILGTENIKAKVAKIYSDIDKEIVRKAILGDKIKELDGSSKLTVEDLQNVNNIVAQIGISPFIEAYKKGVNIILAGRSYDPAPFSAIPIYKGYPKGLSYHLGKILECGAIAAEPGSGRDGLMGLIFEDRFEVYPLNEDRKCTVISVAAHTLYEKSDPYHLIGPDGVIDLTKSVFIQKDERTVSVMGSEFIESKDKWIKIEGAKYLGIRGVCIAGIRDPIMISQIDEILEKQKILLRENFKDLNKYEIFFHVYGKNGVMGSWEKEKNLSHELCIVIEVIGENQDHVKTILGFLRSSLLHYGYKNRISTAGNLAFPFSPSEVIWGEVFEFKIYHLIKLEDYEFPIEVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0H5</accession>
    <name>B8E0H5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamate mutase, MutL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583701.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353234.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1346"/>
    <dbReference type="EnsemblBacteria" id="ACK42620">
        <property type="protein sequence ID" value="ACK42620"/>
        <property type="gene ID" value="Dtur_1346"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1346"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1391"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046680_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0H5"/>
    <dbReference type="OMA" id="LGMRYSA"/>
    <dbReference type="OrthoDB" id="595291at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006230">
        <property type="entry name" value="MutL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13941">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004729">
        <property type="entry name" value="MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01319">
        <property type="entry name" value="glmL_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="461" mass="51315" checksum="5E299324CF0FEA39" modified="2009-03-03" version="1">MKALIFDIGSTFTKGVAYDLEKGEIIGKAKYPSTVSEDVNIGLSKVIEDIKAQTGYRIEEFEIKRATSSAAGGLKIIAIGLVPDLTAEAAKKAALSAGGKVLKVYSYELTSLDLEEILFLKPDIIILSGGTDGGNRYYPLVNAQKLSTLPLNIPFIYAGNKDLRDRIEKIFRENNKEMYITENVMPEYGVININEVQKLIREIFLRNIIHAKGLDKVKKIIDGVVMPTPLAVLKGLEAFSQMYGESILVDVGGATTDVCSVAEGAPTQSGVVWKGLKDPIVKRTVEGDLGVRVSAVSLLEAVGERELEKLANDLKINPKERAYFLSKNTNFIPEKDEDIYFDAILSYYAVKISVERHVGHLEVIYTPMGTLYFQYGKDLRGVKKLLLTGGPLIYNPHKKTILKGAIYSKDEPFVLKPISPEVFIDKEYILFSIGVISEISKEKAKKLIERYMKRMEAWEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0I8</accession>
    <name>B8E0I8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplI</name>
        <name evidence="9" type="ordered locus">Dtur_1359</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583713.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353247.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1359"/>
    <dbReference type="EnsemblBacteria" id="ACK42633">
        <property type="protein sequence ID" value="ACK42633"/>
        <property type="gene ID" value="Dtur_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1359"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1404"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_3_0_0"/>
    <dbReference type="InParanoid" id="B8E0I8"/>
    <dbReference type="OMA" id="CKDGKAN"/>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RIBOSOMAL_L9" evidence="8">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="151" mass="17330" checksum="D1BFDA9BCA7EA8AC" modified="2009-03-03" version="1">MKKVKVLLLRDVNNLGKKGEIVDVSDGYARNYLFPKGLAQEVNEGMLEHLKLQEISQKKKEEKLLEKFRKEKEYIEKEVFVIKAKVGERGKLFGSITSKDIAEIISKKLKIEIDKRQVNLDEPIKSLGEYNIEVKLHPQVVANAKVLIEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0J4</accession>
    <name>B8E0J4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="6" type="ordered locus">Dtur_1365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583719.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353253.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1365"/>
    <dbReference type="EnsemblBacteria" id="ACK42639">
        <property type="protein sequence ID" value="ACK42639"/>
        <property type="gene ID" value="Dtur_1365"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1365"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1410"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0J4"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="49"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="292"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="423" mass="47744" checksum="58D1066705FB5E87" modified="2009-03-03" version="1">MENKVYPITFKKDEDYKIGGVSIPYLGEKYGTPLYILDKETLIFQAQKYINSWKKYYKNKYKVLFAIKALPILEVIRIFKNYGLGALVSTGGELYIALSANVPSEDIYFHGNAKTLKEIEYAIDQKVGAIIIDNFDEYEKIKYVLSKKDTKVKVLVRIIPNIEVNTHKSIRTGQTDTKFGLPIEQALVLIEKINTEKNIIFKGIHSHIGSQIFDISAYVKLSEVLSEVYKELNSKNITVEEMSIGGGLGVAYTKEDNPPDIEDLAREVSNKFSETIGHNFKLICEPGRSLVGRAGITLYRIESRKELGIRKYVSVDGGMSDNIRPSLYGAKYSALIITKGDREEIFSIAGKHCESGDILIKDFSGLWPNPGDYLITFTTGAYNFSMYTWYNATPRPAVVLVENGKDRIIVKRENYEDLLGGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0J7</accession>
    <name>B8E0J7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Homoserine kinase</fullName>
            <shortName evidence="10">HK</shortName>
            <shortName evidence="10">HSK</shortName>
            <ecNumber evidence="4 10">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">thrB</name>
        <name evidence="13" type="ordered locus">Dtur_1368</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583722.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353256.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1368"/>
    <dbReference type="EnsemblBacteria" id="ACK42642">
        <property type="protein sequence ID" value="ACK42642"/>
        <property type="gene ID" value="Dtur_1368"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1368"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1413"/>
    <dbReference type="eggNOG" id="COG0083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041243_0_2_0"/>
    <dbReference type="InParanoid" id="B8E0J7"/>
    <dbReference type="OMA" id="CANRIPH"/>
    <dbReference type="OrthoDB" id="610857at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="12">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="223"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="297" mass="33763" checksum="D7B8BC978556F6D6" modified="2009-03-03" version="1">MRYLIKVPATSANLGPGFDTIGICWDLYLRIDIELNSLEKRILNNNKEEIKKNDLFLQSLAYTLDYLRFKEDLKYTIKIESEIPIGKGLGSSAAAILGGIFTAEIIANKKLEKFEKIKIALNFENHIDNLSACLEGGVVICLKNENEIFFSKLPVYSNIYGVIFIPKYTLSTESARKILPQNYPKEDVIFNLQKLSFLITGLIKGDEALIDMGMDDKIHQPYRFKLVKEYNTLKEELKKFNKKLVLSGAGPSLITLTFSYKKALEILKNLENNLKNKIDGKLMVLKVNNEGIKIENL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0K0</accession>
    <name>RL7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplL</name>
        <name type="ordered locus">Dtur_1371</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583725.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353259.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0K0"/>
    <dbReference type="SMR" id="B8E0K0"/>
    <dbReference type="STRING" id="515635.Dtur_1371"/>
    <dbReference type="EnsemblBacteria" id="ACK42645">
        <property type="protein sequence ID" value="ACK42645"/>
        <property type="gene ID" value="Dtur_1371"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1371"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1416"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0K0"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000121428" description="50S ribosomal protein L7/L12">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <sequence length="125" mass="13204" checksum="0A902FBC309B707B" modified="2009-03-03" version="1">MNKEEIIQAIKEMKVIELVELVKALEEEFGVSAAMPVAAVGAPVAGAAAAAPVEEKTTFDVILKDAGANKIKVLKVVREITGLGLKEAKDLVDSTPKPIKEGVSKQEAEEIKAKLEAEGAVVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0M9</accession>
    <name>B8E0M9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584124.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353663.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1777"/>
    <dbReference type="EnsemblBacteria" id="ACK43049">
        <property type="protein sequence ID" value="ACK43049"/>
        <property type="gene ID" value="Dtur_1777"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1777"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064494_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0M9"/>
    <dbReference type="OMA" id="TRRIMSY"/>
    <dbReference type="OrthoDB" id="1478083at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="82"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="262" mass="30623" checksum="D338E5388D071286" modified="2009-03-03" version="1">MEIVWTGSNLISLSLTEEIDLIKEYSKLIIFDHHKLVNFLKGNDKEKIKDILLRNDIKPLLISHDFKLPLEGENKEILEIYELSKELDLPFLLINPCEKPSNISFNVALEMFAKNLSRSLSKIDLLIVIRINAFSVVNTLSKAYKVLNLIKERERLSLAFDTFHFYLGGEDFDVFRDKDFSQIKFVFLKDAENVPRYYLKENQQVFPGEGVIPLVQILTYLRDGGFNGYIVPEVVRPEYEKMKPEEYVSKLMETTRRIMSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0N6</accession>
    <name>B8E0N6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argD</name>
        <name evidence="4" type="ordered locus">Dtur_1784</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584130.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353670.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1784"/>
    <dbReference type="EnsemblBacteria" id="ACK43056">
        <property type="protein sequence ID" value="ACK43056"/>
        <property type="gene ID" value="Dtur_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1784"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1836"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_0"/>
    <dbReference type="InParanoid" id="B8E0N6"/>
    <dbReference type="OMA" id="FWGWQAH"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="385" mass="42933" checksum="D0ECDCA98952AEFB" modified="2009-03-03" version="1">MKEDRFFPVYKRFKPVFVRGEGVWLFDDQGKKYLDLTSGIGVNALGHSHPEIVKRVKEQIEKLSHVSNLFYNLPQFELLERLASLTKREAFFLCNSGAEAVEAAIKLSRKYFDGQKWKIISMNNSFHGRTYGALSATGQKKYHEGFGPLVPGFIYVPYNDVSALESAIDEETCAVILEPIQGEGGVNPADKEYLKRVREITKELGILLIFDEIQTGIGRTGYFLAEEYYEVEADIILLAKALGGGLPLGAVCTSKDIAQVMGPGSHGTTMGGNLVVCAAGTAVLDIVGNEKFLREVREKGRFLEEKLKDLLELPIVKEIRGRGLMWGIELKDIKVRELQEELIEEGVLVLSAGENVLRLLPPLIVTKEELEKGIETIKEALQKRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Q5</accession>
    <name>B8E0Q5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4097 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584149.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353689.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK43075">
        <property type="protein sequence ID" value="ACK43075"/>
        <property type="gene ID" value="Dtur_1804"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1804"/>
    <dbReference type="eggNOG" id="COG3595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1072541_0_0_0"/>
    <dbReference type="OMA" id="RPLYIEV"/>
    <dbReference type="OrthoDB" id="2114594at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025164">
        <property type="entry name" value="DUF4097"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13349">
        <property type="entry name" value="DUF4097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4097" evidence="2">
        <location>
            <begin position="112"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="259" mass="28199" checksum="3BC1077E12D18238" modified="2009-03-03" version="1">MEEEIKKILKLLEEGKITAEDAEKLIEAIEEKRETKRKGIGVLDIGSIVAEAITSAFSMVPTLVASGIRGGTKVDETFDWDFERPLYIEVLAVDVNMSLSEELKVVVIGEGVFSTNGDLLKIHAGDFNLAIPKLKLVKVNVSAGDLKGKLICNELEIFVKMGDANLEVEADRIQGGVNMGDFEIKLLKSPSLVKLNCHMGDLKIALPENFDGKIDATVSLGDLSFAKKADIIKGDTYIYGAGEKSYMELSCTMGDIKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0U6</accession>
    <name>B8E0U6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="7" type="ordered locus">Dtur_1409</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583761.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353297.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1409"/>
    <dbReference type="EnsemblBacteria" id="ACK42683">
        <property type="protein sequence ID" value="ACK42683"/>
        <property type="gene ID" value="Dtur_1409"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1409"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1456"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_6_0_0"/>
    <dbReference type="InParanoid" id="B8E0U6"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="203"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="21"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="330" mass="38024" checksum="26E6F81BA9F616ED" modified="2009-03-03" version="1">MEIANHRWDNSEKVKPILTKFNKLQKEIESWEKLKTDIEELSEWKDLLEEGDEYKEEFEKKLKEVEKSLKNFEIEMVLQDPHDEANAVLSLHAGTGGTDAQDWTEILLRMYIRWAERKGYQVKILDISPGEEAGIKSATLLIEGDKAYGYLKGEKGVHRLVRISPFDANHRRHTSFALVEVIPELPESTIEIKPEDLKIETFRAGGAGGQHVNKVESAVRITHIPTGIVVQCQNERSQHANKEMALRVLKARLEELEERKRREKIASLKGEVQEISWGNQIRSYVFHPYTLVKDHRTGLEIGNVQAVIDGEIDPFIEAYLFNEFKKKNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0W8</accession>
    <name>B8E0W8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583783.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353319.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1431"/>
    <dbReference type="EnsemblBacteria" id="ACK42705">
        <property type="protein sequence ID" value="ACK42705"/>
        <property type="gene ID" value="Dtur_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1431"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_3_0"/>
    <dbReference type="InParanoid" id="B8E0W8"/>
    <dbReference type="OMA" id="AWKRGVH"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033214">
        <property type="term" value="P:siderophore-dependent iron import into cell"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="312" mass="34601" checksum="2D6B21FD83BE39E5" modified="2009-03-03" version="1">MRLKIALLSAVLIILTFLSVYVGGVKKLSDEVRGKIIWNIRLPRTLLSTLVGGNLGLAGAILQSLFHNPLAEPHIIGLSSGALLGATLYFILSGSTWDIDPLLTPLFAITGSVIVLILLILLNKKFQSSYTLILLGISLNSLLSSVIALILFLKQKTFQGVYFWLLGGFNGKTWNHFCLLASYSNIGILWAFLWRNKFNLLFLSEEEMYSLGFSLRKYQPLIIILLSFLISPSVAVSGSIGFVGLIAPHLMRVWETSDYKWLIPSSFLAGANLLLASDILSRILFYPTEIPVGIITSFLGVPFFMYLLIRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Y3</accession>
    <name>B8E0Y3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmI</name>
        <name evidence="8" type="ordered locus">Dtur_1446</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583798.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353334.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1446"/>
    <dbReference type="EnsemblBacteria" id="ACK42720">
        <property type="protein sequence ID" value="ACK42720"/>
        <property type="gene ID" value="Dtur_1446"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1446"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1493"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_2_0_0"/>
    <dbReference type="InParanoid" id="B8E0Y3"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="289" mass="33351" checksum="C3B2890B3F20255E" modified="2009-03-03" version="1">MGKLYVVATPIGNLRDITLRAIETLKACPVIAAEDTRHTSILLKTYNIQDKILISYHKYNEEKRIELFLDFLLNKNMDIALVSDAGTPCISDPGYKIVKAVREKNIEVIPIPGPSSLTASLSVSGLPLNEFLFLGFLPKEENKKVNKLREIKKSKINTFIIYESPKRIIKTLNIIREIFSNSIVCICRELTKKFEKTYYGEIKKVIEEINNDPYKEKGEYTVIVSWEDNMEREVSFSIEALLIDQIVKHNISLKEAIYKVSKLYNIPKKEVYKKSLELKNKLKEEDFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Y5</accession>
    <name>B8E0Y5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583800.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353336.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1448"/>
    <dbReference type="EnsemblBacteria" id="ACK42722">
        <property type="protein sequence ID" value="ACK42722"/>
        <property type="gene ID" value="Dtur_1448"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1448"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1495"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_0"/>
    <dbReference type="InParanoid" id="B8E0Y5"/>
    <dbReference type="OMA" id="QGLCRTT"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="358" mass="39904" checksum="8F26D051F40091C0" modified="2009-03-03" version="1">MKPERFEKIINLALNLEASDIHLKAGTPPAVRIMKDIVFLKEEPLTPEEVENLAFSIMPPAVRDIFLKNKEVDFPYEKKGLVRFRVNVYTQRQTIAISMRLIKLNIPSIEELGLPTILKNLATKKAGLILVTGPSGSGKSTTLAAMIEYLNQNESLNIITIEDPIEYVFTDKLSLISQREIGIDTSSFYAALKMALREDPNIIMVGELRDLESVSVALQAAETGHLVLSTLHTIDAVSTISRIVDMFPPYQQNQVRYQLASTLVGVISQRLLKRKDKTGLVPACEVLIGTSTVRKWIRENKLSEIPKIIEEGRLEGMQSFNQHLLELYRANIIDANEALMASPNPSDLELAIKGIVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Z5</accession>
    <name>B8E0Z5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353346.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1458"/>
    <dbReference type="EnsemblBacteria" id="ACK42732">
        <property type="protein sequence ID" value="ACK42732"/>
        <property type="gene ID" value="Dtur_1458"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1458"/>
    <dbReference type="HOGENOM" id="CLU_3269163_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="41" mass="4813" checksum="BD48BEA87A2C6B41" modified="2009-03-03" version="1">MAKPRSKKEKRERAIRIVAAVVAVFFLLSIFIIWGMYFIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E100</accession>
    <name>B8E100_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_1463</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583815.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353351.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1463"/>
    <dbReference type="EnsemblBacteria" id="ACK42737">
        <property type="protein sequence ID" value="ACK42737"/>
        <property type="gene ID" value="Dtur_1463"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1463"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1512"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_3_0"/>
    <dbReference type="InParanoid" id="B8E100"/>
    <dbReference type="OMA" id="WSMVYYL"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="165" mass="19324" checksum="426344B28EA1F189" modified="2009-03-03" version="1">MNLPNILTIIRIFMVFPIVLLMDVNPLASGLLFILAIFTDYLDGEIARKYNKVSDLGKFLDPLADKILVLGILTYFVWLRYFSPWIVILILFREFMITGLRLSLVQRGIILPALKSGKLKTLFQDISILFYLWNLPFKYLLLIISLILTLYSGFYYFYKYGKKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E139</accession>
    <name>B8E139_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP synthase (F/14-kDa) subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583854.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353390.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1502"/>
    <dbReference type="EnsemblBacteria" id="ACK42776">
        <property type="protein sequence ID" value="ACK42776"/>
        <property type="gene ID" value="Dtur_1502"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1502"/>
    <dbReference type="eggNOG" id="COG1436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2141923_0_0_0"/>
    <dbReference type="OMA" id="DVYPVRN"/>
    <dbReference type="OrthoDB" id="1997002at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="SSF159468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="112" mass="12567" checksum="FB23B4D780CD88D4" modified="2009-03-03" version="1">MNESKIAVIGLDILVEIFKVFGIDIYPVKNSDEAYEVYKSLSEREYSLIIVLESVAGKIVENLKGREKIPLILPDTFSNKKLGEEILRDIAEKALGIDIISEGEGYYGRKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E141</accession>
    <name>B8E141_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583253.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352783.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0888"/>
    <dbReference type="EnsemblBacteria" id="ACK42169">
        <property type="protein sequence ID" value="ACK42169"/>
        <property type="gene ID" value="Dtur_0888"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0888"/>
    <dbReference type="HOGENOM" id="CLU_1159637_0_0_0"/>
    <dbReference type="OMA" id="IDFTEPA"/>
    <dbReference type="OrthoDB" id="2111342at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="239" mass="27501" checksum="5E08CECB758E3554" modified="2009-03-03" version="1">MKRIFSFLIIFFLGFSMIYAQTGEDILKNLEQKWSLARDISMKMSITVYSYSSKGESLPTKMSMEMKAIKNPEILRIDFTEPALMAGQIILIDGEKKITRMYSPSTKQIIEAPYTMTQTSTMSFSSLPMVGNKEDFSLKVEEIIDKNQKLYKITGVPLKADLKANYSSFEFYITKDYTPIKLIVYDVQNRPYIEIAWQNIKINSNLSPNTLRTFPPGKIIKQKEPLNFNTTMPFMAPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E158</accession>
    <name>B8E158_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583270.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352800.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0905"/>
    <dbReference type="EnsemblBacteria" id="ACK42186">
        <property type="protein sequence ID" value="ACK42186"/>
        <property type="gene ID" value="Dtur_0905"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0905"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.942"/>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_0"/>
    <dbReference type="InParanoid" id="B8E158"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="OrthoDB" id="522981at2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="6">
        <location>
            <begin position="183"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="413" mass="46393" checksum="EABF048363F4174B" modified="2009-03-03" version="1">MSRIRDINLWESGKKKIEWVKNFMPVVNTLESKYSFSQIFKDKTIGMCIHLEAKTARLALAFKNCGAKVVCAGSNPLSTQDDVAAYLVKEGIEVFAWRGESSEDYERNLEEVLKKEPNLIIDDGFDLTVLLYKKFSYLKHKIFGVGEETTTGVKRAKALLKDRGLDFPVVAVNDSKLKFLFDNRYGTGESAISSFMRNTNLLISGRTFVVAGYGWVGRGIAQKLQGLKAKVIITEVDPIKALEAHMDGFSVMPMKEAVKIGDVFITATGNFKVIGEEYFYDLKDGAILANAGHFNVEIDMETLEKIAIEKREVRDNIHEYKLPNGKRVFVIAEGRLLNLAGGDGHPIEIMDLSFGIQFLVMKWLMERGKELPKVVISVSEDIELEIAKIKLDSLGISIDTLTPEQLNYLQSWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E164</accession>
    <name>B8E164_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative anti-sigma regulatory factor, serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0911</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583276.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352806.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0911"/>
    <dbReference type="EnsemblBacteria" id="ACK42192">
        <property type="protein sequence ID" value="ACK42192"/>
        <property type="gene ID" value="Dtur_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0911"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_926298_0_0_0"/>
    <dbReference type="InParanoid" id="B8E164"/>
    <dbReference type="OMA" id="YELEMNL"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="80"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="290" mass="32601" checksum="E9A6FD4A18D65532" modified="2009-03-03" version="1">MKIPKEYLEKIKVKDIMNTDIVRLRPYQDMRSIQEIMRIKRIDAIPIVDDLENLIGLVTVENVINALAKGDINVPCEKYMVRDPKCLKPDDNLYEALIKFRRFRFGRFPVVDEKGKVLGILSTKDIVLNLVDVEDIEGIKEEKKEEAVLILEYPVMGGDFALAGVASSNVKKVLQQLGIGPDIIRKVAVVTYEAEMNIVIHAYRGVLRVKVTPEYIDIVAEDEGPGIPDIELAMQPGYSTAPDNIREMGFGAGMGLPNIKNSSDELHIDSIVGRGTTVHSRIYLKRERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E170</accession>
    <name>B8E170_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583282.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352812.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0917"/>
    <dbReference type="EnsemblBacteria" id="ACK42198">
        <property type="protein sequence ID" value="ACK42198"/>
        <property type="gene ID" value="Dtur_0917"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0917"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125323_0_0_0"/>
    <dbReference type="InParanoid" id="B8E170"/>
    <dbReference type="OMA" id="FYTTRKT"/>
    <dbReference type="OrthoDB" id="1776812at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="178" mass="20167" checksum="661244AB63D0F2DB" modified="2009-03-03" version="1">MKELSLHLLDLVQNSIEAGARNIYIEMKKDLENKKLFLKIKDDGKGIPPEVLEELKNPFFTTRKTRKVGLGIPLFWELVRSCNGNLNVRSEIGKGTEIIAEVPYDCIDLPPLGDISGTILSLIVANPDLNLNFKFEKNGDIFEFSTEDLKRELNGIPLNSLEVISFLKKYIYENLGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E172</accession>
    <name>B8E172_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="7">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0919</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583284.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352814.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0919"/>
    <dbReference type="EnsemblBacteria" id="ACK42200">
        <property type="protein sequence ID" value="ACK42200"/>
        <property type="gene ID" value="Dtur_0919"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0919"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.956"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_0"/>
    <dbReference type="InParanoid" id="B8E172"/>
    <dbReference type="OMA" id="DRMLMEG"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="539"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="569"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="596" mass="65196" checksum="4A2496BA82E3F739" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E180</accession>
    <name>B8E180_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352822.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0927"/>
    <dbReference type="EnsemblBacteria" id="ACK42208">
        <property type="protein sequence ID" value="ACK42208"/>
        <property type="gene ID" value="Dtur_0927"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0927"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1110052_0_0_0"/>
    <dbReference type="OMA" id="GWSAKTH"/>
    <dbReference type="OrthoDB" id="377888at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Zn_dep_PLPC" evidence="2">
        <location>
            <begin position="43"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="260" mass="30739" checksum="EC01EF2B9659E2D7" modified="2009-03-03" version="1">MKIYDKITNVMRGKLTIRKTVFLSFLIIFILFLNPIFGWSAKTHQKIVKEALYSLPKEYQRKLVPYLDELLEGSVAPDKVYRDFDNHIFHVHGNKGRGPEKVREKYYEIISLIQERKPWRLIAFQLGVLSHYIADLNQPLHTDSSKKEDQFHSKYEKDAEVINPKITSDLTFIKYPTRHILDSIFNANRFYKAIEKAYLEGDQFKDVSKVTQKQINKATYDTASYFYSILTRGSRGTTLMDLIYDFIDYIFSLFRINFKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E196</accession>
    <name>B8E196_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0943</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583308.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352838.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0943"/>
    <dbReference type="EnsemblBacteria" id="ACK42224">
        <property type="protein sequence ID" value="ACK42224"/>
        <property type="gene ID" value="Dtur_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0943"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.980"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_0"/>
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    <dbReference type="OMA" id="KMPERDY"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="246" mass="26636" checksum="7DD2E2D1BA5263AE" modified="2009-03-03" version="1">MLKDRVALVTGGSRGIGRAIVLSFAKEGAKVLINYKGNEKAAMETLEEVKKIGGEGEVFKADVSIEEEVDKMFNFVLEKWGRLDILVNNAGITRDNLLIRMKSEEWDQVINTNLKGVFYCTRSAVKIMLKQRYGRIINISSVIGLRGNIGQANYAAAKAGIIGFTKAVAKEVASRGITVNAVAPGFILTDMTEVLSEEMKKKALEEIPMGRFGDPKDVASAVKFLASDEAGYITGVVLSIDGGLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1I3</accession>
    <name>B8E1I3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, LacI family</fullName>
            <ecNumber evidence="6">5.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0177</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582593.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352122.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0177"/>
    <dbReference type="EnsemblBacteria" id="ACK41508">
        <property type="protein sequence ID" value="ACK41508"/>
        <property type="gene ID" value="Dtur_0177"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0177"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.183"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_0_0"/>
    <dbReference type="InParanoid" id="B8E1I3"/>
    <dbReference type="OMA" id="WGKQLIV"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="343" mass="38779" checksum="AE26FA782C112322" modified="2009-03-03" version="1">MKKNGITIKDIAKEAGVSPTTVSNVIHKKYEHVSPETVKRIEKIIEEKGYIPNMLARSLVKRNSKIIGVINCLIPTARGSFIQDPFHTVFLGGVEKELSKRGYFIMLRTVNDKDELISLLKTWNLDGVIVTGIFEDEFYEALLNTDIPVVLIDSYVDGDKFLKVGLEDFKGGYLATRYLIEKGHREILFVSPKIKPKGVLEERLKGYKRALEDYGIPFKSEHIYEHGTRVEECIELGRKLSKRKDFTAIFVTADIMAAGIMSGLIEMGVKIPEEVSIVGFDDLDISLITSPRLTTIHQDVEVKGTIAARMLIDYLEGKVIKERTVILPVRIVERESVRDIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1K3</accession>
    <name>B8E1K3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582613.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352142.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0199"/>
    <dbReference type="EnsemblBacteria" id="ACK41528">
        <property type="protein sequence ID" value="ACK41528"/>
        <property type="gene ID" value="Dtur_0199"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0199"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032306_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1K3"/>
    <dbReference type="OMA" id="DWRYRAR"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="190"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="480" mass="55158" checksum="2C3346731582807E" modified="2009-03-03" version="1">MSGEFHYNIELYPEDSKKLLLLELEVPEGIKEIIIKATLEPEYLSHEESKRLIKEAIKTYISQGFDPLDIKQVPNDILEKIIRGFSPLKNVVNIRVLDAEGNFRGTGDQRFTKGIPIKIGVCDSTVGCVSGEIKAGIWKLILEIKQILKKCILNIVVYLHREEITKVKDIILSYNPVVREPYDKSGWVKGDVHLHSYHSDGELSIEELIKFSIKRGLDFIFLTDHNKISGFHTIEWEFYPIYGGIEFTTFWGHFLGLGIKEYIPWDLANPEVGIRKLSERVRSQGGVFCVAHPYTISAPVCPGCRCELYLDYNFVDAMEVWTGSFEMRRFEITEALKKWRELLKNGYRITALGGSDMHKIEDIKEDVPLVYAYVEDLSEESILKAIREGRVYITTGPQVEFYINGHSIGENVDFKEDLILKYSCEKESELKIIYNGDEYIKIPGTKKGAFHLKLKDPGYVYLEFWEGKKLIAFTNPIYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1L4</accession>
    <name>B8E1L4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase and metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582624.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ACK41539">
        <property type="protein sequence ID" value="ACK41539"/>
        <property type="gene ID" value="Dtur_0210"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_9_0"/>
    <dbReference type="InParanoid" id="B8E1L4"/>
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    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
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    </dbReference>
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        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="156"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="282"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="465" mass="54222" checksum="86B187E53DA7F92D" modified="2009-03-03" version="1">MKELNEKLIETLILDTLKEMVIVLDKDMNIVYANKSAQISLDLDLKNITDKKCYKLWHYRDTPCINCPVIRSMETKEVSEGEVTTPDGRVWHIKSYPILNEKNKVIGAIEITQEITEKKIFEAEIQYLTFHDKLTGLYNRAFFEEELKRLDTQRQLPISIVMGDLNGLKLVNDAFGHEEGDKLLKSVAEILKKSCRKEDIIARWGGDEFVIIFPKTPRDVVERICERIKENCEKYNQEIDKKHPIPLSIALGHATKEEKDEKMLEVLKRAEDRMYRNKLIEGKTFRDSVLKSLKNLLWENTFESESHENKIKELVSKMADILTLSDIEREALIFLSYFHDIGEIAIPKEIMRKPEKLTEDEFKKVKTHPEVGYRIAETSYELAPIAEYILTHHEWWNGEGYPRGLKKEEIPLVSRIFAIVDAYEVMISGRPYKRAKTKEETIEELKKFAGIQFDPNLVEVFANII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1M4</accession>
    <name>B8E1M4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352163.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0220"/>
    <dbReference type="EnsemblBacteria" id="ACK41549">
        <property type="protein sequence ID" value="ACK41549"/>
        <property type="gene ID" value="Dtur_0220"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0220"/>
    <dbReference type="HOGENOM" id="CLU_1913730_0_0_0"/>
    <dbReference type="OMA" id="IYLLWRP"/>
    <dbReference type="OrthoDB" id="2128191at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="132" mass="15282" checksum="407F5E0312F079A5" modified="2009-03-03" version="1">MKVIGRPATVWLSLPSDLLIGESTLEIEGDVLVEKRKVFFEERKTYLLLREIEGIEITQKGDKIFSFLFLAFLMGRLYLLSFISLLIYLLWRPTFLIIHGKNLQIGISINSKDIKPYEEFAEFLLKKVKEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1W6</accession>
    <name>B8E1W6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582834.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352363.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0448"/>
    <dbReference type="EnsemblBacteria" id="ACK41749">
        <property type="protein sequence ID" value="ACK41749"/>
        <property type="gene ID" value="Dtur_0448"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0448"/>
    <dbReference type="HOGENOM" id="CLU_176022_3_0_0"/>
    <dbReference type="OMA" id="RFCPLYR"/>
    <dbReference type="OrthoDB" id="2089632at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="63" mass="6783" checksum="81EA7BEAF0776A8C" modified="2009-03-03" version="1">MNVGKTDAVIRVIIGIVLPHLTKWGVVSGTAWGVILHIIGTILVLTAALRYCPLYKLINKSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Z9</accession>
    <name>B8E1Z9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldehyde Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582867.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352396.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0484"/>
    <dbReference type="EnsemblBacteria" id="ACK41782">
        <property type="protein sequence ID" value="ACK41782"/>
        <property type="gene ID" value="Dtur_0484"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0484"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.509"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1Z9"/>
    <dbReference type="OMA" id="WHKLIEQ"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008911">
        <property type="term" value="F:lactaldehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="2">
        <location>
            <begin position="3"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="464" mass="50467" checksum="36D203A518691471" modified="2009-03-03" version="1">MVKTINVYNPYDGTIVETIPESTLEDVDRAIEKAEKGKKIMAEMSLFERSEILRKTAEIIEKNKEDFASTLVKEVGKTIKEARIEVRRAVEIFKLASEEAKRIHGETLPFDSIPNGEKRVGYFIRVPVGIIAAITPFNVPLVLASHKIAPAIAGGNSIVFKPSTITPLADIKLAKALIEAGLPEEAINVVVGPGSTVGNAIVKDPRIRMISFTGSKDVGMEILKNAGLKKISLELGSNSALILSKNGDISSAVSATIKGGYAVAGQVCISVQRVFVQKEIYDEYLEKLIEGVRNIKVGDPMKEDTDMGPVISEESAKRIEEWIKEAVDMGAKVVFGGKREKTLFEPTVVINVPTEAKLFSKEVFGPVVVVNSFNKLSEAIEMANNSEYGLQAGIFTNDIEEAFYAIKKLEVGGVMINDAPSYRADFMPYGGVKGSGIGREGVKYALEEMTEIKTVCFNLRGGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E237</accession>
    <name>B8E237_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583397.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352928.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1034"/>
    <dbReference type="EnsemblBacteria" id="ACK42314">
        <property type="protein sequence ID" value="ACK42314"/>
        <property type="gene ID" value="Dtur_1034"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1034"/>
    <dbReference type="HOGENOM" id="CLU_1413174_0_0_0"/>
    <dbReference type="OMA" id="NPFIPVI"/>
    <dbReference type="OrthoDB" id="2125733at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="194" mass="21524" checksum="94911A2DF4FC8F65" modified="2009-03-03" version="1">MDLKSLFNNPKQRMMFLVILLVLVGLIGGYYVITNYILPPSEETVVTTPKRVRTTQETYTLAQVLETLTQQTAVVFTYSTVELGRSNPFIPVIDLTPKKPSLVQSSPAASSSVNISVTPKVSSEPIKTWYSGFKLTGIVRGRDRSYAIIEEGERGYVLREGDLLRSDIYVSKINDNSVILKRGNAYATLKLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8E272</accession>
    <name>B8E272_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583432.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352963.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1070"/>
    <dbReference type="EnsemblBacteria" id="ACK42349">
        <property type="protein sequence ID" value="ACK42349"/>
        <property type="gene ID" value="Dtur_1070"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1070"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014641_0_0_0"/>
    <dbReference type="InParanoid" id="B8E272"/>
    <dbReference type="OrthoDB" id="855577at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="4"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="274" mass="30748" checksum="335F67A9B5610069" modified="2009-03-03" version="1">MPLTGNLKEFDLVSLLQILSGKFSTGRLIITKPFKKGILYLKEGKVINSEVGKLKGMPGFLELFTWEEGNFEFVDEDVSNISVAISMSSEALILEAARIMDEWHEKRKKLGSLTCVPFFPDPSRAIPSSVQVLLLRKDPESMTPEEKERFILSNIDGRRDFATIARISGLGTLLAIDVVLNSLEEGRIALKDLVNLQHVVPEKVGNVSSNDPAVQKMLRIMDGKMNMEKILLEIEEERGKIIPELVKLVKAGRVRLKEGVEYLPRLSQENLYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E277</accession>
    <name>B8E277_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583437.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352968.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1075"/>
    <dbReference type="EnsemblBacteria" id="ACK42354">
        <property type="protein sequence ID" value="ACK42354"/>
        <property type="gene ID" value="Dtur_1075"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1075"/>
    <dbReference type="eggNOG" id="COG3920">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045351_1_0_0"/>
    <dbReference type="InParanoid" id="B8E277"/>
    <dbReference type="OMA" id="GSIAIVH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="H_kinase_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA_2" evidence="1">
        <location>
            <begin position="280"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="478" mass="55782" checksum="B6C1E7A8C2F76117" modified="2009-03-03" version="1">MTRIKKETTYLLEELKDYVPYLSLISDLLSADIYLYQPITDLSAVILIAEAHPKIVPPLSLRQEVGKLIFFEDDPNLFEVINTGKQKLVKNGIVIGGFPVEEEIYPIKKDNNLIGILKVQRNLLVHSEFPYNARSYKETSQWLIKNLIKFKLNWKGYNEPLTEGEGIMILDRDGIVLFANMSAVRLFRTLGEVGNIWGRKIKDSFFYKYIETYTETGIIRVYGEETYEEYNDETRSFYRRIFPLTKGDQNLWRVFYVIKETTELKQKERELKFKSVLIKEIHHRVKNNLQTIASLLRIQIRRLESESAKLALQESINRINSIAYVHESLSKFEEDRVDIVEVAEKLLNAFKQTYEHLPCKFNFYKNRKSVFLSSKKATSVSLIMNELLQNATKHGAYEDVETEINLHLYQENQDIIMIVENKVLKDKNVSFDISFTKGSLGFQLIQMLTEEIKGKIDIERKLDSLSVKIRFPKGEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E285</accession>
    <name>B8E285_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ordered locus">Dtur_1083</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583445.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352976.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1083"/>
    <dbReference type="EnsemblBacteria" id="ACK42362">
        <property type="protein sequence ID" value="ACK42362"/>
        <property type="gene ID" value="Dtur_1083"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1083"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1119"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_4_0_0"/>
    <dbReference type="InParanoid" id="B8E285"/>
    <dbReference type="OMA" id="TRLCRAH"/>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="100"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="215"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="227"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="474" mass="54092" checksum="4F25EB98604EFD2C" modified="2009-03-03" version="1">MSYEDLVLKTRAELVEIARELKIPGYYRMTKEEMIEAISRKLEEGEVDLESPKSEVSSLLTIEKGAGIKGLEIEEKKEEKEEKEEKQEQKDKVIIDGFECIYREGYLEITEDGYGFIRKNFKPSDEDVYISASQIKKFGLRYGDLIGGMVRPPKENERWYAILRIDTVNGRDLMHSRQRPKFDDLIPFHPTERLKLETTPDEVDTRLIDLLAPIGKGQRGLIVSPPKAGKTTLLKKIANGISANHKEVKLFILLIDERPEEVTDFRRSVQGEVIGSTFDEPPERHIQVAKLVLERAKRLVEYGEHVVILLDSITRLARAYNWAVPSSGRTLSGGVELAALHHAKEFFGAARNIEGGGSLTILATALIETGSRMDDVIFEEFKGTGNMELVLDRKLADRRIFPAISISRSGTRKEELLYPEDQLKKIWFLRRTLIGQEEGEAIEGLKRMLRETRNNEEFLRVIDGIIKKGNTIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2A1</accession>
    <name>B8E2A1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583461.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352992.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1099"/>
    <dbReference type="EnsemblBacteria" id="ACK42378">
        <property type="protein sequence ID" value="ACK42378"/>
        <property type="gene ID" value="Dtur_1099"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1099"/>
    <dbReference type="eggNOG" id="ENOG5033BT9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166657_2_1_0"/>
    <dbReference type="OMA" id="RFFIFVI"/>
    <dbReference type="OrthoDB" id="2193875at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025470">
        <property type="entry name" value="DUF4321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14209">
        <property type="entry name" value="DUF4321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="81" mass="9141" checksum="57B5A40BEF2950A8" modified="2009-03-03" version="1">MRRNKTSTRMFILLLILGFLVGGVLAEALSDKLEILKKGINIGFSPINLDFYFFVFTLGFDLRLNLGSVIGVLIVLLFYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2B1</accession>
    <name>B8E2B1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_1109</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583471.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353002.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1109"/>
    <dbReference type="EnsemblBacteria" id="ACK42388">
        <property type="protein sequence ID" value="ACK42388"/>
        <property type="gene ID" value="Dtur_1109"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1109"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1145"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_2_2_0"/>
    <dbReference type="InParanoid" id="B8E2B1"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="377" mass="44570" checksum="89283A22FB651F00" modified="2009-03-03" version="1">MISSNPIGIYIHIPFCVRKCPYCDFVSFRYSKEEEERYISHLLREIDMKSKGETIDTIYLGGGTPSILSLKGLEKIFEFIQEKFKLSKGVEISMEVNPGTVDREKIKVWKELGINRISIGAQSFIEKELKILGRIHDTDDIYKTFHMLREADFKNINIDLIYSLPFQEQEDFYFSLKEAVKLNPEHISIYNLMIEEGTLFYKMYLESKIKLPDSDMEAEMFSFAMNYLKDNGFIHYEISNFSKNENYKCKHNLKYWNQEKYYGFGVSAYSYDPPVRYGNCRNLYVYYGKIKKGILPIEEREFLTGDKLAKDFLFLRLRLMEGISKKEFENRFDKRIEYFMKNYSVFLENGLIKEEGDRVALTEKGILLANEIFQDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2C1</accession>
    <name>B8E2C1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA synthetase class II (G H P and S)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583481.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353012.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1119"/>
    <dbReference type="EnsemblBacteria" id="ACK42398">
        <property type="protein sequence ID" value="ACK42398"/>
        <property type="gene ID" value="Dtur_1119"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1119"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873552_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2C1"/>
    <dbReference type="OrthoDB" id="1236894at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="1">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="327" mass="39279" checksum="790D896F6747F978" modified="2009-03-03" version="1">MKRESLEKIIRRRLELWGYNEIRIPILYEDIWGKENLIYFEKNGKFLALRPEITREILKSIRYDKIPKRMFYMGPIFKLNGREVEENYQIGWELIYKPSLWRDVEVLLIIKEVFEDIGVDDYIIELGNTKIWDFILRFIKDEEKVKSLREFLVKRDYVSFLDKSDLSNSELKSEILNLFYYDSCDEDCVFLNSSLRDEINFLNSFKKLLVKLGFKEDKLIVNPALMRPYEYYDGIIFEVYLKNSKTSLGGGGSYIERNKYNELLYGFGFAFVEEKLLELVNGTFLEENIRYFVYPEEQFIRIYEDMRKEREKGIISVFIPKDEGVLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2C8</accession>
    <name>HIS6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="1">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ImGP synthase subunit HisF</fullName>
            <shortName evidence="1">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisF</name>
        <name type="ordered locus">Dtur_1126</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583488.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353019.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2C8"/>
    <dbReference type="SMR" id="B8E2C8"/>
    <dbReference type="STRING" id="515635.Dtur_1126"/>
    <dbReference type="EnsemblBacteria" id="ACK42405">
        <property type="protein sequence ID" value="ACK42405"/>
        <property type="gene ID" value="Dtur_1126"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1126"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1163"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_0"/>
    <dbReference type="InParanoid" id="B8E2C8"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="OrthoDB" id="1522718at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000134992" description="Imidazole glycerol phosphate synthase subunit HisF">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <sequence length="252" mass="27508" checksum="FA5324B3C7DB3F64" modified="2009-03-03" version="1">MLAKRIIPCLDTIGKKVVKGTSFINVRVVGDAKELARRYEKEGADEIVLLDITASEEGRSTFVDVVTDVASELFVPLTVGGGIKNIEDVRRLLKAGADKVSINTSAVENPDLINQIASEFGSQCLVVAIDVKRRGKKSWEVYIKGGKVPTGIDFKDWVIEVEKRGAGEILLTSIDADGHLSGYDYELLEYALSYSNLPLIASGGAGSLEDLYKALKIGVDAVLAASIFHFGTYSIPEVKRYLREKGIWVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2E0</accession>
    <name>B8E2E0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ordered locus">Dtur_1510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583861.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353398.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1510"/>
    <dbReference type="EnsemblBacteria" id="ACK42784">
        <property type="protein sequence ID" value="ACK42784"/>
        <property type="gene ID" value="Dtur_1510"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1510"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1559"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_1_0"/>
    <dbReference type="InParanoid" id="B8E2E0"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="193" mass="22235" checksum="4AD7F7506965CDF7" modified="2009-03-03" version="1">MERLGIIGLGNPGYEYANTRHNVGFMVVDYLQNFYKFPSYQKTNFNLLTFGKISNTKVYLVKPQTYMNLSGIGVKEFIEKFAFAPEELLVIHDDLDLPIGTIRIKFNGKDGGHNGIKSIIKEINTSNFYRLRIGIGKPQDKNQIVEYVLGKFNEDELKTIEKILQSSHQIIETIIKEGWDKAQNLYNRKCLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2G8</accession>
    <name>B8E2G8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ffh</name>
        <name evidence="9" type="ordered locus">Dtur_1538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583887.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353426.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1538"/>
    <dbReference type="EnsemblBacteria" id="ACK42812">
        <property type="protein sequence ID" value="ACK42812"/>
        <property type="gene ID" value="Dtur_1538"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1538"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1587"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_0"/>
    <dbReference type="InParanoid" id="B8E2G8"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="266"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="107"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="245"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="436" mass="49368" checksum="320DFCD942400305" modified="2009-03-03" version="1">MFENLTSRLQEIFRKLRGKGKLTEKDIEEALREVRQALLEADAHYKVVKELLNNVKTKALQEDVLKSVTPAEQIIRILYYELLNILGGEKVDLNLGDKKPGIILVVGLQGSGKTTTCAKLAYRLSQEQRRVLLVGADTFRPAAGKQLQILGEKIKVPVYIDGSNPFEIIDGALKVAREKFSDVMIVDTTGRLHIDEEMMNELSELNKRYHPSEILLVVDGMTGQDAVNIAEKFNEKLPLTGVILTKMDGDARGGAALSVKAITGKPIKFIGVGEKIEDLEYFYPDRLASRILGMGDLASLVEKIEKNIELEKMAKLEEKLKKSKFDLEDFYIQLKELKKVGTFEQILDMLPYVPKNKINVELSEKEIKKFLAIIESMTPEERRNPSIINGSRRQRIARGSGTSVQDVNRLLKQYFQTLELIKQINKGKKSMFPFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2I2</accession>
    <name>B8E2I2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, BadM/Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583901.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353440.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1552"/>
    <dbReference type="EnsemblBacteria" id="ACK42826">
        <property type="protein sequence ID" value="ACK42826"/>
        <property type="gene ID" value="Dtur_1552"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1552"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2I2"/>
    <dbReference type="OMA" id="GPIAMVP"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="144" mass="16630" checksum="170AC9A5603DCC9A" modified="2009-03-03" version="1">MFRVSAKLEYGLRAMIFLGKNYPHEKLTLSQISQEENISREFLAQLMSELRRANLVESYKGITGGYTLTKPPHEITLKEIFEALEGPIQIIDCIHIDNKCNKERSCYSKNIWIFIEKKIIDLLGSLTLEDLINGTIRKEEILTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2K7</accession>
    <name>B8E2K7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmB</name>
        <name evidence="2" type="ordered locus">Dtur_1577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353465.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1577"/>
    <dbReference type="EnsemblBacteria" id="ACK42851">
        <property type="protein sequence ID" value="ACK42851"/>
        <property type="gene ID" value="Dtur_1577"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1577"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1625"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077150_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2K7"/>
    <dbReference type="OMA" id="PWPKAGH"/>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036265">
        <property type="term" value="P:RNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="339" mass="39925" checksum="6E5CF289C1FA2A52" modified="2009-03-03" version="1">MILNQKSNYFLDWKEVFENENPIFLEIGMGNGEFIVHMAKENLNANFIGIDVSKEIFRKAVSRVKRSGLKNIRLMRIEGSEFLCKFVKSETLSGVYINFPDPWHKKSHKERRLVNEPFIYLVSDRLKNEGIFIFVSDNEEYTKSVWGLLKKFDNFSPLWDHGLRRDFPEYYKTKYARKWLALGLPIYYIGFKKTGNIEIPEYVKEYYPLLNLSKEDLYMPLVEFKIKKEKSSEFIKDILSILPKGLIYRDKNALIKVLDFYYNEESIIADIVCVEGSFRQRFFLDISLKKEVLKISIHDSDDPDPTFGIHKTLAIFASILKEKFTGLELLQNTTRIKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2N0</accession>
    <name>B8E2N0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (adenine(58)-N(1))-methyltransferase TrmI</fullName>
            <ecNumber evidence="4">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer composed of a dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583949.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353488.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1601"/>
    <dbReference type="EnsemblBacteria" id="ACK42874">
        <property type="protein sequence ID" value="ACK42874"/>
        <property type="gene ID" value="Dtur_1601"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1601"/>
    <dbReference type="eggNOG" id="COG2519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2N0"/>
    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="OrthoDB" id="944891at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="111"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="284" mass="32438" checksum="E66D43DC605F086B" modified="2009-03-03" version="1">MKIRRKGKISEGEWVVLFDSKRRYLIQVEREKIFHFHKGYIRHNDIIGMEEGSIIRSSQGANLLVLRPTYSDFILEMPRGAQIIYPKDIATILVWADIYPGARVLEAGIGSGALTIALLQAVGETGTVISYEIREDFAKRALSNIENFLGKKDNHILRLKDIYEEIIDENIDRIILDLPEPWRAIDNILKALRPGGIFLAYTPTIIQAQKTVEALKGTKSFTLIETIETLLRPWQIEGLSVRPFHRMVAHTAFLTVARRIVTQEENISPMVVPSEERGENYEIE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2N5</accession>
    <name>TGT_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tgt</name>
        <name type="ordered locus">Dtur_1606</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583954.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353493.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2N5"/>
    <dbReference type="SMR" id="B8E2N5"/>
    <dbReference type="STRING" id="515635.Dtur_1606"/>
    <dbReference type="EnsemblBacteria" id="ACK42879">
        <property type="protein sequence ID" value="ACK42879"/>
        <property type="gene ID" value="Dtur_1606"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1606"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1655"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2N5"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="OrthoDB" id="1165356at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002099">
        <property type="term" value="P:tRNA wobble guanine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000197999" description="Queuine tRNA-ribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="1">
        <location>
            <begin position="248"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="1">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <sequence length="388" mass="45138" checksum="00D0043B5E99221C" modified="2009-03-03" version="1">MIFEIIVRDKKTRARLGKLKTFHGEINTPVFMPVGTQGAVKTLSPEEVEKVGAEIILSNTYHLFLRPGHEIVRKGGGLHKFMGWEKPILTDSGGYQVFSLARLRRIDEDGIYFNSHIDGTRYFYTPELVMEIQKSLGSDIIMPLDICLGYGASYWETKEALEITLRWLKRSIDYKNNSNMDHQLLFGIVQGGFYKELRKEAVERMLNIDLPGLALGGISVGEPKDKMYEIIDYTVSLLPEEKPRYLMGVGAPEDLVVGVSMGIDMFDCVLPTRLARHGVFYTSKGRKNIKNAQYKEDFSPLEEDCDCYTCRKFTKAYIRHLFLQHETFSYRLLTIHNLRFLFRLMENIRKSIREGRLEEFKKEFLTEYLRDDRENRLEKEELWSKLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Q0</accession>
    <name>B8E2Q0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acid phosphatase/vanadium-dependent haloperoxidase related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583969.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353508.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1621"/>
    <dbReference type="EnsemblBacteria" id="ACK42894">
        <property type="protein sequence ID" value="ACK42894"/>
        <property type="gene ID" value="Dtur_1621"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1621"/>
    <dbReference type="eggNOG" id="COG1963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073969_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2Q0"/>
    <dbReference type="OMA" id="QPIEVFF"/>
    <dbReference type="OrthoDB" id="1864362at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003832">
        <property type="entry name" value="DUF212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31446">
        <property type="entry name" value="PTHR31446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02681">
        <property type="entry name" value="DUF212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="157" mass="17627" checksum="565532D4E653DADD" modified="2009-03-03" version="1">MTNIIQIIEDLLQNPVFIIPMMVAMITQGIKGLIRSIQERKFLWRAFFEWGGMPSSHSALVVSLSLIIGIKEGFNSTIYILSMFFAGIVIADAIGVRLATEEQAKVINKIIQKEIKNPELKEIYLKESIGHTPIEAITGGIIGLILTHFIYYGFFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Q1</accession>
    <name>B8E2Q1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583970.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353509.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1622"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42895">
        <property type="protein sequence ID" value="ACK42895"/>
        <property type="gene ID" value="Dtur_1622"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1622"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_0"/>
    <dbReference type="InParanoid" id="B8E2Q1"/>
    <dbReference type="OMA" id="FHTNFPQ"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="199"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="402" mass="46756" checksum="7140414BF3397FB4" modified="2009-03-03" version="1">MKIAFFSDTYIPHKNGVATSLSFLKKTLEEESHSVYLFIPFIPNIPKERNTFTLPSITFPFQKEHRIALPYSIKYDLMLRNMEPNIIHTHTPFSLGIFGLYMGKRIKIPIVHTYHTLLPDYAYYIWDHFPHFVKKNIIDEERAKRIAIWISREYCNHSDLIIAPSTKIKRLLKNFGIQKPIEILPNGIDLDRFKKIPKPEARKSLGLPTDVILLLFVGRLGKEKNIEFLIEVMKYIKENNEKLIYLVIVGDNPDKRVMEELKNKAKTLNVYDRTIFTGYLEYERVIEAYYASDIFVFSSITETQGLVILEAMASGLPVVAIDDDAISDFVKDGINGFLVPNNQENKRLFSEKIKNLIEDKDLYTKMSLHALETSRSFHIKNLNKKLLALYEDLIREYNNSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Q3</accession>
    <name>B8E2Q3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF87 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1624</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583972.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353511.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1624"/>
    <dbReference type="EnsemblBacteria" id="ACK42897">
        <property type="protein sequence ID" value="ACK42897"/>
        <property type="gene ID" value="Dtur_1624"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1624"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023842_2_0_0"/>
    <dbReference type="InParanoid" id="B8E2Q3"/>
    <dbReference type="OMA" id="CLVSQRP"/>
    <dbReference type="OrthoDB" id="600220at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF87" evidence="2">
        <location>
            <begin position="134"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="557" mass="62968" checksum="46C7A1833460221B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2R4</accession>
    <name>B8E2R4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-phytase</fullName>
            <ecNumber evidence="2">3.1.3.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.1.3.26" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583496.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353028.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1135"/>
    <dbReference type="EnsemblBacteria" id="ACK42414">
        <property type="protein sequence ID" value="ACK42414"/>
        <property type="gene ID" value="Dtur_1135"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1135"/>
    <dbReference type="eggNOG" id="COG4166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_6_0"/>
    <dbReference type="InParanoid" id="B8E2R4"/>
    <dbReference type="OMA" id="GMGWFPD"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008707">
        <property type="term" value="F:4-phytase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="72"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="520" mass="60000" checksum="D6356EBC349FF010" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2S6</accession>
    <name>B8E2S6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M16 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583508.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353040.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1147"/>
    <dbReference type="EnsemblBacteria" id="ACK42426">
        <property type="protein sequence ID" value="ACK42426"/>
        <property type="gene ID" value="Dtur_1147"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1147"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1184"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_0_0"/>
    <dbReference type="InParanoid" id="B8E2S6"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="1">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="2">
        <location>
            <begin position="166"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="420" mass="48177" checksum="4F85AD32DCBFD4C4" modified="2009-03-03" version="1">MNISEIELKNGLKIIHDYILSRKTINIIVAIKVGSRHEEKIEHGLAHFVEHLLFKNNSGRGIDEIRKEIDRLGGELDAFTTKETTYFTLKILSYHFVSGVKLLSDIILRPRFSEEEINLEKSVVREEIRMYKDSPEELVFDNFFKASWDSHPLVREILGTEKSVSNFNKDLVISFYNKHYKLNNMIIGISGDVPSKRIEEVLDFYFTQNTSSKFLISSAQKPPKYRPKSVFLKRNFEQVQILWGTEGYVPGDPNRESLALLSVSLGGGISSRLFRELREKRGLVYSVETHILSFKDASLFGIYTATAPQTVVETFKTLAQEKEKLIKEGLSKEELDLAKRQTINSILMAIESPSQRLFYLIDSYITYGKIVPWTDKIKKIRKVTLEDINSTIKDIFSKPFAMSVVGPINSQHKEILKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2V1</accession>
    <name>B8E2V1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583533.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353065.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1172"/>
    <dbReference type="EnsemblBacteria" id="ACK42451">
        <property type="protein sequence ID" value="ACK42451"/>
        <property type="gene ID" value="Dtur_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1172"/>
    <dbReference type="HOGENOM" id="CLU_1812725_0_0_0"/>
    <dbReference type="OMA" id="IRFVRQR"/>
    <dbReference type="OrthoDB" id="2141572at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="149" mass="16844" checksum="0F2D4E603BE83038" modified="2009-03-03" version="1">MKRGFSFIEVIVIVSILAILLGIALISFRSSPDKKLILENIVNQFKEDIRFVRQRAIINKTTWTLSLIPSPTYTTYTSYTFLDDKNKTVLRTLTNLDQVKSTATLFSFDKDGIFTADALETSATLTFQIETYSATIRINPMGYIEVTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2V9</accession>
    <name>B8E2V9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583541.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353073.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1180"/>
    <dbReference type="EnsemblBacteria" id="ACK42459">
        <property type="protein sequence ID" value="ACK42459"/>
        <property type="gene ID" value="Dtur_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1180"/>
    <dbReference type="HOGENOM" id="CLU_1459127_0_0_0"/>
    <dbReference type="OMA" id="KIWAGSS"/>
    <dbReference type="OrthoDB" id="2116086at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="185" mass="20381" checksum="186CB6EE03EEFCD4" modified="2009-03-03" version="1">MRIDKEKGQSLVGVVVFTIILMILVLSLTGATIWSYALNKRARDRAEAQDIAKNIIETTKIWAGSSEANFDALVENEVNSTRAIPAIPTIRPAIPADPPENDRLYTDFYNIPKVNGAPKYVVQFLVKDYQSPGSSIAIMKRITVRVYYAKPNGEINTSIHKPGSGAPPKRYENPLAELAGVVTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2W3</accession>
    <name>B8E2W3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583545.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353077.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1184"/>
    <dbReference type="EnsemblBacteria" id="ACK42463">
        <property type="protein sequence ID" value="ACK42463"/>
        <property type="gene ID" value="Dtur_1184"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1184"/>
    <dbReference type="eggNOG" id="ENOG502ZP1C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_428105_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2W3"/>
    <dbReference type="OMA" id="AFTHAVW"/>
    <dbReference type="OrthoDB" id="766046at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="639" mass="69863" checksum="467D2BDE06B1B2DF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E310</accession>
    <name>B8E310_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583592.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353124.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1232"/>
    <dbReference type="EnsemblBacteria" id="ACK42510">
        <property type="protein sequence ID" value="ACK42510"/>
        <property type="gene ID" value="Dtur_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1232"/>
    <dbReference type="eggNOG" id="COG5011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083579_1_1_0"/>
    <dbReference type="OMA" id="IQVSDMY"/>
    <dbReference type="OrthoDB" id="1514287at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2344" evidence="1">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="213" mass="25406" checksum="F0084ADC7875D3CB" modified="2009-03-03" version="1">MENRVVYRLAFFKLNLLKYVGANDFLNFLGRALRRANIPVKYSEGYNPRPLISLGFPCPVGVESRREYIDLTLQEDMEEKELIKKLNDQIPNDIRFYEAYKIKKSSLIEDTYGIDYELYIFTHLKDPFLLEFKNLDSLEHRKILARRGNSIKEIKPFDYIKEISYQNLRDNIFLIKLKTIKLENTILRGEEFLELFYIKPVLIKQIREVILNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E321</accession>
    <name>B8E321_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsA</name>
        <name evidence="8" type="ordered locus">Dtur_1243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583603.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353135.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1243"/>
    <dbReference type="EnsemblBacteria" id="ACK42521">
        <property type="protein sequence ID" value="ACK42521"/>
        <property type="gene ID" value="Dtur_1243"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1243"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1283"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037850_3_2_0"/>
    <dbReference type="InParanoid" id="B8E321"/>
    <dbReference type="OMA" id="DGIIRHT"/>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="405" mass="44863" checksum="ABC027F4D1C28703" modified="2009-03-03" version="1">MSDFIGAIDLGSTKVAVVIANLSEKNEELELIGFSMIPSKGISYGVINDIQEASACIKEAVQRAVRMAGIRSIPKMIATISGEKITAIPSRGMIIVKSREQEVTESDVRRAIEAAKATSIPEDREVIYHVVRGFRLDGQNGIMNPIGMIGTRLESDLLLVTHDKVQLRNIINAFQKAEINIEGFIPQEIAASEAVLTPEEKNLGVVLVDIGGDLTNLAVFKEGYLYAIGILKLGGERITKDIAITLKIPTEEAERAKKIIGTLKEEKEESLEVMSLQQKRIKINTSQVREIIQPRVEEILDFVLKKLEELNSPIELIPGGIVITGGTALLDGLEEFAQEYLKVPVRVSRSLRVYNIFEEKDAVFYSSAVGALERITRTVSTDESSKNFLDYLKEIFKNIFSPFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E332</accession>
    <name>B8E332_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transferase hexapeptide repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583981.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353520.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1633"/>
    <dbReference type="EnsemblBacteria" id="ACK42906">
        <property type="protein sequence ID" value="ACK42906"/>
        <property type="gene ID" value="Dtur_1633"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1633"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1682"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086901_0_0_0"/>
    <dbReference type="InParanoid" id="B8E332"/>
    <dbReference type="OMA" id="PHYNYVG"/>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="224" mass="24605" checksum="993352658059830E" modified="2009-03-03" version="1">MFEPEEFFDLSGIEKELFENVNLVWEVLRKLEKFLKEYARPEIRGVIKGGVFIEGNVFIDEGTVIEPFVYIKGPAYIGKNCEIRQGAYIRGNVFIGDNCVVGHTTEVKNSVLLSGAKAPHFNYVGDSILGHNVNLGAGTKISNLKIGLSGTVKIKVKEEVYDTGLRKLGAIIGDDSETGCNSVLNPGTIIGKRVLIYPNASVRGFIPENSIVKFKPNLDITDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E343</accession>
    <name>B8E343_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583992.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353531.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1644"/>
    <dbReference type="EnsemblBacteria" id="ACK42917">
        <property type="protein sequence ID" value="ACK42917"/>
        <property type="gene ID" value="Dtur_1644"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1644"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="InParanoid" id="B8E343"/>
    <dbReference type="OMA" id="RIDHKAT"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="254"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="495" mass="55477" checksum="2A86200E747D2369" modified="2009-03-03" version="1">MNQDLLLKMEKISKSFPGVKALDQVDLEVYKGEILALVGENGAGKSTLMKILTGVYQKDEGRILFKGKEISPQNPHEAQKLGISIIYQEFNLAPNLDIATNIFLGNEPRKGKFIKIFDYKKAYEESLKLLDLLGLNLSPDTLVKDLTVAEQQMVEIAKALAQKTELIIMDEPTSALAGREVKKLFEIMRRLKSENISIIFITHRLEEVFEIADRIVVLRDGKRVGELPAQRDKYDDVIRMMVGREIRVIPKPSTKTEEPIFEVRNLSSKKIKNISFQLRKGEVLGIAGLVGAGRTEIIRAIFGADPIISGEIYLEGKRIEIKSPKDAVQQKIGLVPEDRKLQGLILDMAVYENISLPSLIYLFPNGIIKKKTEYDLAEYFVKKLQIKTPSIFQKVINLSGGNQQKVVLAKWLALKPKILILDEPTRGIDVGAKAEIHRLIGEMAQEGIGIILISSELPEILALSDRILVVSKGRITGEISKEEATQEKIMQYAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E360</accession>
    <name>B8E360_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphomethylpyrimidine kinase</fullName>
            <ecNumber evidence="2">2.7.4.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.4.7" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ACK42934">
        <property type="protein sequence ID" value="ACK42934"/>
        <property type="gene ID" value="Dtur_1662"/>
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    <dbReference type="PATRIC" id="fig|515635.4.peg.1712"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="DNRHTHG"/>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
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    <dbReference type="PANTHER" id="PTHR20858">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53613"/>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="263" mass="29837" checksum="9421BA91E4ACA955" modified="2009-03-03" version="1">MPSKTVVKILVIAGLDPSGGAGIFLDIKTIQRLGGYAFGIPTCLTVQNTQKVYKVYEINPRYFLKTFEVLIKDVGELDSVKIGVLYSKKIIDLTIELIKKYQLKNIVLDPVINPTKGVLLLKKDAFSSFLRLISLCTVITPNIPEAEILSGKRIKSLEDMETSIEEISKKFEIENIVLKGGHLNIENKVYDLLYSRNRFVLFEKEYLKDQNIHGTGCLFSSILSFFLAQNLNIEKAFYETQNFFQKIIKKTIKIGKGQDLVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E365</accession>
    <name>B8E365_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584014.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353553.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1667"/>
    <dbReference type="EnsemblBacteria" id="ACK42939">
        <property type="protein sequence ID" value="ACK42939"/>
        <property type="gene ID" value="Dtur_1667"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1667"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="InParanoid" id="B8E365"/>
    <dbReference type="OMA" id="IKMLSGA"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="257"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="502" mass="55632" checksum="9BFF061C1F85F489" modified="2009-03-03" version="1">MEPILRMEGISKAFPGVQALDRVDFEAYAGEVMALVGENGAGKSTLVKILSGVYKRDSGRIYLEGKRVEIQDPYHAQLLGISTIHQELNVTPNQTVAQNIFLGREIKRKGIWGFLGFVDKKEIEERAKKLLERVGANIPPDELVKNLSVAQIQLVEIAKALALKAKIIIMDEPTSALGPEEVEKLFEVIKQLKDQGIAIVFISHRLEEVFRIADRITILRDGKLVGYMSKDEATPDKVIYLMVNRPIGDMFKREEGIKGEPILEVRNLSSNVVKNVSFTLYKGEILGIAGLVGSGRTELVRLIFGADPKKSGEIFIEGNKVEINSPEDAVKFGIGLVPEDRQNQGLILNMPIRENIGITIIKKLLKLLNFVDKAKLTKISEEFVRRLNIKTPSVFEKVLYLSGGNQQKVVLSKWLASEPKILILDEPTRGIDVGAKAEIHAIMSQLARSGISIIMISSEMPEVLAMSDRILVMSEGKIVAEVSREEATQEKIMAYASGNIVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E373</accession>
    <name>B8E373_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha amylase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584022.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353561.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1675"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42947">
        <property type="protein sequence ID" value="ACK42947"/>
        <property type="gene ID" value="Dtur_1675"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1675"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006462_2_4_0"/>
    <dbReference type="InParanoid" id="B8E373"/>
    <dbReference type="OMA" id="CARTPMQ"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="39"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="499" mass="59082" checksum="B741D5F5082A7DB6" modified="2009-03-03" version="1">MRKKFFIKKAFVLIFILLIFITYIHGYNEPWYKDSIFYEVFVRSFADSDEDKVGDINGLIEKLDYFKNLNINALWLMPIFPSISYHGYDVTDYYDIHPAYGTLEDFENLVKKAHEKNIKIILDLVINHTSSRHPWFVSATSSYTSPYRDYYIWSPKKPDKNPNLWYQKPTGYYYALFWSEMPDLNFDNPKVREEVKKIAKFWIEKGVDGFRLDAVKHIYDDDYKNIQWWKEFYSYLKGIKPDIYLVGEVWDNEYKIAEYYKGLPSNFNFPLADKIINSVANQRDLGLIEFLQFERELFKESNPNFIDAIFLRNHDQVRVRTSFGGSIDKSILAGSIYLTLPGTPFIYYGEEIGMEGAKPDEYIREPFKWTDDMKSKYQTYWIIPRYNFIGNGIAFDTEEKDPNSIYNHYKRILELRSKYKALSLGSIERIETQDKSILAYKRELNNEGLIVIHNLNRVETTFNLSFSVKNEDILYIRNAKLNNNKVILGSYSTVIIKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E382</accession>
    <name>B8E382_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584031.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353570.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42956">
        <property type="protein sequence ID" value="ACK42956"/>
        <property type="gene ID" value="Dtur_1684"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1684"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_5_0"/>
    <dbReference type="InParanoid" id="B8E382"/>
    <dbReference type="OMA" id="VDFGHTH"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="400" mass="44038" checksum="2D00123F2EDC898D" modified="2009-03-03" version="1">MKPVNIKSMRMTNVSLVLDTIRRMGPISRYDISKITKLSPSAVSSIVENLINVGIVKETPAKVTKVGRRPIELTLNETGYYPIGIEIEKDKITGILMALSGKILKSKVINLNTTDVNEVLGSVVNVYRSLIEDVNKEEIIGVGVAVPGTINRKEGVCIFSPNLGWRNINIKEYLGQYIKDYPLFIEHIIKAVTYGEMWYGAGIGKDNIICVRVGSGVSAGFVLDGKLYRGPNDRAGEFGHTVIERNGKKCKCGSYGCLETYVSTQVLYEKVFEGIQKNAYTKVNIENKTKDEILDEIIEAGKSGDRFILNIFEEMGTYLGIGIANLINLFNPEIIIIAGGLSKAGELLLEPVRRIVNLHAFPPIPEIMVTKLGALTGPIGAASEVIEETLLKKIFEKTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E383</accession>
    <name>B8E383_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584032.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353571.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42957">
        <property type="protein sequence ID" value="ACK42957"/>
        <property type="gene ID" value="Dtur_1685"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1685"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1735"/>
    <dbReference type="eggNOG" id="COG1814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065373_1_0_0"/>
    <dbReference type="InParanoid" id="B8E383"/>
    <dbReference type="OMA" id="ADDEMRH"/>
    <dbReference type="OrthoDB" id="745826at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006880">
        <property type="term" value="P:intracellular sequestering of iron ion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01044">
        <property type="entry name" value="Ferritin_CCC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039376">
        <property type="entry name" value="Ferritin_CCC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="289" mass="32895" checksum="F1ABF5A92193D861" modified="2009-03-03" version="1">MDKKLIMILEKMQKNEITEYFVYKKLSEWERDERNKKIFLEIAEDELKHFNQLKDYTKKDLKPDKIKIFLTLFLTKILGFTFTTKLMERGEDRAIEGYSDLLSSLPNINKIIEEEKTHEQKLLEILDEERLHYVGSIVLGLSDALVELTGTLAGLTFAFQNNKLISLSGLVTGISAALSMAGSEYLSTKAESSERNPLKAAIITGITYIITVIILIFPYLLTPNYALSLVLALVSSILLVLIFNYYISVAKDLDFKKRFVEMSIIIFSVSFISFAIGLIIKRVLGINLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3B7</accession>
    <name>B8E3B7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584066.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353605.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1719"/>
    <dbReference type="EnsemblBacteria" id="ACK42991">
        <property type="protein sequence ID" value="ACK42991"/>
        <property type="gene ID" value="Dtur_1719"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1719"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8E3B7"/>
    <dbReference type="OMA" id="DNIIIMR"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="318" mass="36343" checksum="3BC670991F219F3A" modified="2009-03-03" version="1">MKQEILLRVENLNKVFTIGSIFSRVRIRAVNNVNFEIGNSEIFTLAGESGSGKTTVAKIILGFLEPTSGKILYKGKDISELQKDRAKDLLRKEVQAVFQNPFETFNPLRRVSNYLMETVKNFGISERPEEVIESALNLVGLTWNEVKDKYPSEFSGGQLQRISIARSLLTNPTLLVADEPVSMVDASLRMSIVNLFKDLKEKRGVSVLYITHDLATAYYVSDRIAIMFRGEIVEIGSVEKVLMDPKHPYTMLLKESIPEPDPKKKWTKDIKILTLEEEEYQMKGCKFISRCPYRMEKCKNPVPDVEVDDRLVKCYLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3D2</accession>
    <name>B8E3D2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584081.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353620.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1734"/>
    <dbReference type="EnsemblBacteria" id="ACK43006">
        <property type="protein sequence ID" value="ACK43006"/>
        <property type="gene ID" value="Dtur_1734"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1734"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1786"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_0_0"/>
    <dbReference type="InParanoid" id="B8E3D2"/>
    <dbReference type="OMA" id="AHERYMT"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="8"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="229" mass="25774" checksum="B9A11BDDDEF0610E" modified="2009-03-03" version="1">MLLKELREEVYRMNMELPKNNLVVMTSGNVSGKDPHTNYVVIKPSGVKYEDLSPEKMVIVDLEGNVVEGDLKPSVDTLSHLVVYRNRKDIGGIVHTHSPYATAFALLGKPIPVYLTSHADYFGEEIPIGRYASPLPLEDVGNALLEVINKDDRPSWVKKHSPFVPVVLLKNHGVFTFGKTPTEALKYAVMIEEIAKTCYLALSLGKPEPLPDIEIEKWYTRFHEIYGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3D8</accession>
    <name>B8E3D8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584087.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353626.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1740"/>
    <dbReference type="CAZy" id="CBM35">
        <property type="family name" value="Carbohydrate-Binding Module Family 35"/>
    </dbReference>
    <dbReference type="CAZy" id="GH39">
        <property type="family name" value="Glycoside Hydrolase Family 39"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK43012">
        <property type="protein sequence ID" value="ACK43012"/>
        <property type="gene ID" value="Dtur_1740"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1740"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1792"/>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005346_0_0_0"/>
    <dbReference type="OMA" id="WPYEDLG"/>
    <dbReference type="OrthoDB" id="956236at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="885" mass="100979" checksum="FD26ED6E590A58BB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYG7</accession>
    <name>B8DYG7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582435.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351963.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0008"/>
    <dbReference type="EnsemblBacteria" id="ACK41349">
        <property type="protein sequence ID" value="ACK41349"/>
        <property type="gene ID" value="Dtur_0008"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0008"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076588_0_0_0"/>
    <dbReference type="OrthoDB" id="1650353at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="258" mass="29834" checksum="CA80CA7C5C06CC8D" modified="2009-03-03" version="1">MAIVRRFYSLLVLGWKIWTNWTEWYWFLLYSFVRPLFMVEILFLVVYFARGKEAMDYFYFILAGNLLFYILSGTSSGMVWTIFDDRNFYETLIPIYIAPGSFLFKIIARSFGVGFSEMFSAFVILFLFILLGSSYQLSHSFFLYVFLFLLAGIGFGLFLASFSLFMGEGANYLIEGTVSALQLLLRFLSFINPFLYLIEGGRRSMGLKSLFLNHISSQQLLVYSLLTTFLSLILGIGSFNLAEKISKRRGTLTRKVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYH5</accession>
    <name>B8DYH5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">grpE</name>
        <name evidence="6" type="ordered locus">Dtur_0016</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582443.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351971.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0016"/>
    <dbReference type="EnsemblBacteria" id="ACK41357">
        <property type="protein sequence ID" value="ACK41357"/>
        <property type="gene ID" value="Dtur_0016"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0016"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.16"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_6_3_0"/>
    <dbReference type="InParanoid" id="B8DYH5"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="174" mass="20716" checksum="611717F089508D34" modified="2009-03-03" version="1">MEEKDLIENEEKEKTEEYVPNEWEIKYVRLQAEFENFRQRLRREKEEWQEIANARLLKEIVEIMDNFQLALESIKHTRKKDAIIEGVQMIYKQFENLLEKEGVVKMETIGKNFDPNLHEAVGIEEVSDGEDNVILKEISPGYLFKNRLLRPARVIVSKKIQKKEVDEHGEDSRN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYH6</accession>
    <name>DNAK_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaK</name>
        <name type="ordered locus">Dtur_0017</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582444.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351972.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DYH6"/>
    <dbReference type="SMR" id="B8DYH6"/>
    <dbReference type="STRING" id="515635.Dtur_0017"/>
    <dbReference type="EnsemblBacteria" id="ACK41358">
        <property type="protein sequence ID" value="ACK41358"/>
        <property type="gene ID" value="Dtur_0017"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0017"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.17"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_4_0"/>
    <dbReference type="InParanoid" id="B8DYH6"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_1000119702" description="Chaperone protein DnaK">
        <location>
            <begin position="1"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="607" mass="66977" checksum="F3F789F4A5F849F3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYI4</accession>
    <name>B8DYI4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine amidotransferase class-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582452.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351980.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0025"/>
    <dbReference type="MEROPS" id="C44.A09"/>
    <dbReference type="EnsemblBacteria" id="ACK41366">
        <property type="protein sequence ID" value="ACK41366"/>
        <property type="gene ID" value="Dtur_0025"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0025"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.25"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061941_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYI4"/>
    <dbReference type="OMA" id="FKGVGFP"/>
    <dbReference type="OrthoDB" id="447435at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012375">
        <property type="entry name" value="Glu_synth_lsu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018774">
        <property type="entry name" value="GOGAT_lg_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="365" mass="41658" checksum="71FA1010AF4CEAC8" modified="2009-03-03" version="1">MLREGEIRIPSACGLIGYINRKWKTSSGDHIISAMTVMRERGNGLGAGFAGYGIYPDRKDYYAFHLFYENIKAKEETSEFLYKYFDVVREEKIPTRKVKTIKNPPLTYRYFLKPKEEYLEEEEISEEDFVAEKVMEINSKIDGAYVFSSGKNMGVFKGVGYPEEIGEFYRLEEYKGYIWTAHTRFPTNTPGWWGGAHPFALLDWSVVHNGEISSYGANVRYIEMFGYKCTLKTDTEVITYIVDLLVRKHKLSWDITAKILSAPFYSVIEGMEEEEKNKLKALRAVYQSCLLNGPFAIIVGFSNGIVALNDRIKLRPLVAAEKGETLYVASEEAAVKEICQNPDRVWMPKGGEPVIGLLEEVEVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYJ5</accession>
    <name>B8DYJ5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0039</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582463.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351991.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0039"/>
    <dbReference type="EnsemblBacteria" id="ACK41377">
        <property type="protein sequence ID" value="ACK41377"/>
        <property type="gene ID" value="Dtur_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0039"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.40"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_8_1_0"/>
    <dbReference type="InParanoid" id="B8DYJ5"/>
    <dbReference type="OMA" id="NIAGMQV"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="453"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="525" mass="58397" checksum="CCAF0A03657B88E3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYK1</accession>
    <name>B8DYK1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582469.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351997.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0045"/>
    <dbReference type="EnsemblBacteria" id="ACK41383">
        <property type="protein sequence ID" value="ACK41383"/>
        <property type="gene ID" value="Dtur_0045"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0045"/>
    <dbReference type="eggNOG" id="ENOG5033AHY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1370284_0_0_0"/>
    <dbReference type="OMA" id="MENFLYE"/>
    <dbReference type="OrthoDB" id="1233799at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045706">
        <property type="entry name" value="DUF6062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19538">
        <property type="entry name" value="DUF6062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="199" mass="24235" checksum="5D1BB11161A61ADF" modified="2009-03-03" version="1">MKGKSLIHKNWEEAFHWEGCPLCYLVQKALRSYMENFLYENVNDVLLRKSIREKGGFCENHHLQLLTFRDFLGISIIYEDIIKNCIIPSLKNKEIPETKSCIFCEKEEEYEKLYIQSLSEVLKNQETFNLWKEIAYDFCQPHKEKIKTISPDTYKRIEPYLYHKKRKYPEYFYESFSWDKDYSELFLKKLRILELKKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYL0</accession>
    <name>B8DYL0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ordered locus">Dtur_0054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582478.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352006.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0054"/>
    <dbReference type="EnsemblBacteria" id="ACK41392">
        <property type="protein sequence ID" value="ACK41392"/>
        <property type="gene ID" value="Dtur_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0054"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.55"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_1_0"/>
    <dbReference type="InParanoid" id="B8DYL0"/>
    <dbReference type="OMA" id="VEICVYE"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="179"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="79"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="462" mass="54188" checksum="5DD8CA19F60A10ED" modified="2009-03-03" version="1">MNNKFIIVIFGGLGDLAQNKLYPVIYSLYKKYRLLNCTKIISTGRRPNVDKEEFLKILEKSIKTHDDSFFSLFDFVKFDLEKEEEYNHLKNMLSNFKEEEFIFYLATPPTTFETIIKNLGEFLKSFPNKRKIVIEKPFGYNLYSAQKLNQLIKIYFKEEEVYRIDHFLGKETVQNIFGLRFSNIIFEGIWNRNFIDHIQISALEDIGVEGRLGYYDKVGALRDMIQNHLIQILSIVAMEPPCCINEKEIRDEKIKVLKSIREIKREDVPLYAVRGQYEGYLIDENLSQSNTETYAAVKLFIENLRWDGVPFYLRTGKKLKRKETSIIIVFKKIPGLFSKILDCMPQEDIIGFKIAPENKIILSFQLRPLGGSMLSCPVSTSMEWTGPNIEAYETLFMDIIEGDQSLFIRKDEIEKSWEIVQPILDFWKDDPNIPIYPQGSWGPKEAEELIRRDGREWRYIDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYM0</accession>
    <name>CINAL_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_0064</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582488.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352016.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DYM0"/>
    <dbReference type="SMR" id="B8DYM0"/>
    <dbReference type="STRING" id="515635.Dtur_0064"/>
    <dbReference type="EnsemblBacteria" id="ACK41402">
        <property type="protein sequence ID" value="ACK41402"/>
        <property type="gene ID" value="Dtur_0064"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0064"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.65"/>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_9_3_0"/>
    <dbReference type="InParanoid" id="B8DYM0"/>
    <dbReference type="OMA" id="PGVPYEM"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000118919" description="CinA-like protein">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <sequence length="411" mass="45246" checksum="AC8965E62C991BE4" modified="2009-03-03" version="1">MRCEILSVGTELLLGDILNTNAQYLSRRLADLGIPVYFHTTVGDNPERLKKALEIAFSRSDMVIATGGLGPTQDDLTKEISAEFFNKKLVLHEESLKRIKEFFERRGLNLTEGNIKQAYIIEGSRVIPNDWGTAPGIILEEGGKILILLPGPPKEMIPMFETYVVPYLSTFSSGIIYSKVLRVCGIGESFMEEKVKDLIKSQTNPTIAPYAKEGEAILRITARAKSKEEAEKMIEGVVKEIRKRLGDYIYGEGETSLEEVVVNLLLEKGLTISVAESCTGGLISARLVNVPGVSKVFKGSIIAYDNEVKIKELNVPEEIFKEYGAVSSQCAMKMAEGIAKKMGTDVGLSATGIAGPEGGTLEKPIGLVYIGLYIRGEMSYKELRLSGDRNRIRLYTTINGLDLLRRGLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYS6</accession>
    <name>B8DYS6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582543.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352072.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0126"/>
    <dbReference type="EnsemblBacteria" id="ACK41458">
        <property type="protein sequence ID" value="ACK41458"/>
        <property type="gene ID" value="Dtur_0126"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0126"/>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_1_0"/>
    <dbReference type="InParanoid" id="B8DYS6"/>
    <dbReference type="OMA" id="VRHTSCS"/>
    <dbReference type="OrthoDB" id="1691156at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="134" mass="15357" checksum="40535418F056C988" modified="2009-03-03" version="1">MFYEISVSTPQKIALVDVTEKIEETVKESKVRNGICFIYVPHTTCGILINENYDPSVIRDILNAYERIVPQNLPYAHLEGNSPAHIKSTIVGVNTFVFIREGKLKLGTWQGIFLAEFDGPRYRKLWIDIIEDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYU4</accession>
    <name>B8DYU4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0145</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582561.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352090.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0145"/>
    <dbReference type="EnsemblBacteria" id="ACK41476">
        <property type="protein sequence ID" value="ACK41476"/>
        <property type="gene ID" value="Dtur_0145"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0145"/>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_4_0"/>
    <dbReference type="InParanoid" id="B8DYU4"/>
    <dbReference type="OMA" id="IATYPYH"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="5">
        <location>
            <begin position="310"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="392" mass="44595" checksum="ABE79D433839564C" modified="2009-03-03" version="1">MYLIVGNGISGINTAEVIRERDKEGRIVVISRERYPYYSRPQLIEFLAGNITIDQLPFYPEEWYKEQNIEIHYDENAIKVDTQRKILITDKNEYSFDKLILATGAIPFKPNIENINAEGVFTLRNIDDALSILSYIKEKERVILLGCGLLGLETGRALSQRGLKIIGLEFFPRLLPRQLDEEGAKILQNIIEKKFSFEFYLGVKAQKIIGSKRFEGIELEDGRKIMGDMLIVSAGIIPHIEVAKNSGIETNKGIIVNNFMETNIENIYAVGDCAEHNGRIYGIIPACMEQSEVVGRNVTSEKVEYKGTLPFNSLKVTGVDLTSIGEIEPKDNCEVFVKKDEERGFYRKLIFRDNMILGAILLGNKRSYVNKILSLMKKKEEVLNKEELLNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYV2</accession>
    <name>B8DYV2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0153</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582569.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352098.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0153"/>
    <dbReference type="EnsemblBacteria" id="ACK41484">
        <property type="protein sequence ID" value="ACK41484"/>
        <property type="gene ID" value="Dtur_0153"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0153"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_0"/>
    <dbReference type="InParanoid" id="B8DYV2"/>
    <dbReference type="OMA" id="FPWLRPT"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="148"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="209"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="411" mass="47330" checksum="E55A41A49BDD371D" modified="2009-03-03" version="1">MKIAWKITLIYTGILIFLISILSFLFYIQTENVLMDENKKDLYRTFMGLGVGRGFMMGRMMGGRISSFYISEKENIIQDPFNLGLVEKEGLYQSPDGSYILVVKRNNYFIGKDITSTMTALDRLRETCISIAILGVVPSLLIGYFLSQRILFPIRRIIRDARLIDIKNPGKRVELPSAKDELWELANTLNLLFDRIEKAYKREEEFSSDISHELKTPLTSILGYIRMLKRWGKEDKRVLDESLDILENATLDMINMVDTLLKISRVPEEIEKEDINVKEFLAEILEKYKNIYPDFDFRIYVEGDPMVKTSKKVIEIILGILIDNGVKNSLDKKEIYIGYREGKFFVRDFGKGIPGEEIPKIFERFYKLDKSRSSKGYGLGLSLAKKLAESIGSDIIVESKEGEGSIFYIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYX4</accession>
    <name>B8DYX4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582685.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352214.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0274"/>
    <dbReference type="EnsemblBacteria" id="ACK41600">
        <property type="protein sequence ID" value="ACK41600"/>
        <property type="gene ID" value="Dtur_0274"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0274"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_1_2_0"/>
    <dbReference type="InParanoid" id="B8DYX4"/>
    <dbReference type="OMA" id="NALMHLY"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="50"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="250" mass="29541" checksum="8BC1A83A87F3ECE2" modified="2009-03-03" version="1">MEGRFESNWEAVFEPEDYLYFYEDMLTDEQTQIEVDFIRRELDLKDPKKILDMACGYGRHANRLALYGHEVVGVDISEKFLEMAMKEAEKLNVNVRYVLKDIREIDFEEEFDVVISMFTSFGYYEDEDNLKILKNVAKALKRGGKFLLDLSNRDFILRNFLPYVVIEREGNYMIDFNIVDITEGRIYNKRVVIRDGVKKEKPFFIRLYAPTEIKFILESLGLKVIKFFGGYDSSPLSIYSRRMIIISEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYY0</accession>
    <name>B8DYY0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF0313 protein Dtur_0281</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0313 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582691.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352220.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0281"/>
    <dbReference type="EnsemblBacteria" id="ACK41606">
        <property type="protein sequence ID" value="ACK41606"/>
        <property type="gene ID" value="Dtur_0281"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0281"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.294"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018288_2_0_0"/>
    <dbReference type="InParanoid" id="B8DYY0"/>
    <dbReference type="OMA" id="TCMYYTG"/>
    <dbReference type="OrthoDB" id="229299at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01251">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022946">
        <property type="entry name" value="UPF0313"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024560">
        <property type="entry name" value="UPF0313_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013704">
        <property type="entry name" value="UPF0313_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32331">
        <property type="entry name" value="PTHR32331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11842">
        <property type="entry name" value="DUF3362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08497">
        <property type="entry name" value="Radical_SAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01069">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03904">
        <property type="entry name" value="SAM_YgiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="295"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="589" mass="68750" checksum="795A8C7572C6859E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYY8</accession>
    <name>B8DYY8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Auxin Efflux Carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582699.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352228.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0291"/>
    <dbReference type="EnsemblBacteria" id="ACK41614">
        <property type="protein sequence ID" value="ACK41614"/>
        <property type="gene ID" value="Dtur_0291"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0291"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075776_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYY8"/>
    <dbReference type="OMA" id="GLSCFPF"/>
    <dbReference type="OrthoDB" id="1601278at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="317" mass="36469" checksum="08B3AD2EDB0728F8" modified="2009-03-03" version="1">MFLTVFSKFLPVFLLFLLGNLFRIKSYVSENAVSELKKLVVNVFLPSLLFLSFSRTGIEPKHLIIVVIMFLVCTILLFIGRFFQKLLKVDSKYFYLLFTGFEAGMLGYSLFTVFYGTENVFKFAIIDLGQVTFVFFVLVGILLSIKEGRRSWNFKSMLYSFLKTPVIIAIFLGIIFQKTKLIDIFMKNILLSSILETIEMLSVMTVPFISLIIGYELKFQKENLSLSFKVVILRNVVLIVLGFLINYIVINKMLGLDNIFQRALITMFLLPPPFIIPLYIRDEDREDKVFISNTLALSTLFTMLIFLLMNILGGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYZ4</accession>
    <name>B8DYZ4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0065 (bug) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582705.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352234.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0298"/>
    <dbReference type="EnsemblBacteria" id="ACK41620">
        <property type="protein sequence ID" value="ACK41620"/>
        <property type="gene ID" value="Dtur_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0298"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.314"/>
    <dbReference type="eggNOG" id="COG3181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045683_1_1_0"/>
    <dbReference type="InParanoid" id="B8DYZ4"/>
    <dbReference type="OMA" id="PMTLIGK"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005064">
        <property type="entry name" value="BUG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042100">
        <property type="entry name" value="Bug_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42928">
        <property type="entry name" value="PTHR42928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03401">
        <property type="entry name" value="TctC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017082">
        <property type="entry name" value="YflP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="323" mass="35439" checksum="131DC7EA90C6473B" modified="2009-03-03" version="1">MFSKRLFIVLALLLILLITIGSGVDFPTRPVQIIVPWSAGGATDVLFRSIASVFPKYANGQPLVVNNIPGGGAVPGTMEFLRAKPDGYTLLSFAAPILIKSHMDPVEFSADSFEPVILIVNDPCYILVRKDAPWKDLREYVEYAKQNPGKITIGNGGAGGGTHLAALAFESFAKIKLTHVPFEGGGPAVTALVGGHINSYMGAAPEGLANVDSGQLRILGVFGSKRLDKYPDVPTAKEQGFNFQFGMWRGVAVQRGTPKEIVDRLHTIFYRAMRDPEFQKKARELSLTLDYKGPASFAKFIKDYDKYYENLIKSNKLGNKYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ09</accession>
    <name>B8DZ09_DICTD</name>
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        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352249.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0314"/>
    <dbReference type="EnsemblBacteria" id="ACK41635">
        <property type="protein sequence ID" value="ACK41635"/>
        <property type="gene ID" value="Dtur_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0314"/>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_5_0_0"/>
    <dbReference type="InParanoid" id="B8DZ09"/>
    <dbReference type="OMA" id="MKQFKDW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="396"/>
            <end position="493"/>
        </location>
    </feature>
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        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="494" mass="59249" checksum="2A964CA445710B11" modified="2009-03-03" version="1">MYKVFIADDEYYIREGLKRIVNWERLGFKIVGEAEDGIEALEKIKRINPDLCVIDVKMPEMDGLELISNIKSYKNSTKIIILTGYPEFDYAIKAIELGVNFYILKPVDPEILKEKLEKVYHELEKERILYESSKGRIMERFLKKHLDVKEDEINNIFCLDLPWNSYQVVLVDWEDKSLDKIKVLEDISYYFPFSFLVDNFIGFIIKDFSKEKRKLINLRDHLRNKYRDYFCFSIGEKVYDFLSISSSFEKAKSLFSRRFLYEEKGFLVYPKGKKNLKPHLELEKINNVALWVEVIEDLDFVKLWELLEDKMIKHMVYEDEEQEIKLSYFNLYVDIVTLLITRYSQFKEKSFKYLKNRIFEEFFNKRTIIDLHVFTKEILTELISDFSEIMGRNPLVKITEYIESNFYKDLKLKDVAKEFGYNPCYLGKIFKKYTKEKFNTYLDRVRINKAKELLRRGLKVSEVAEMVGYKDTDYFICKFKKYTGKSPQNFKESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ28</accession>
    <name>B8DZ28_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal methylation motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352268.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0340"/>
    <dbReference type="EnsemblBacteria" id="ACK41654">
        <property type="protein sequence ID" value="ACK41654"/>
        <property type="gene ID" value="Dtur_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0340"/>
    <dbReference type="HOGENOM" id="CLU_480403_0_0_0"/>
    <dbReference type="OMA" id="VITEVMY"/>
    <dbReference type="OrthoDB" id="740009at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="148"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="567" mass="63232" checksum="66F615885D97DE01" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ69</accession>
    <name>B8DZ69_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582780.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352309.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0391"/>
    <dbReference type="EnsemblBacteria" id="ACK41695">
        <property type="protein sequence ID" value="ACK41695"/>
        <property type="gene ID" value="Dtur_0391"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0391"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005531_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZ69"/>
    <dbReference type="OMA" id="VITSEQW"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038766">
        <property type="entry name" value="Membrane_comp_ABC_pdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30287">
        <property type="entry name" value="PTHR30287"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="652"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="701"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="270"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="635"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="737" mass="84850" checksum="EA77424B206701D5" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ79</accession>
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        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
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        <name evidence="6" type="ordered locus">Dtur_0519</name>
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    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomaceae</taxon>
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    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352426.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0519"/>
    <dbReference type="EnsemblBacteria" id="ACK41812">
        <property type="protein sequence ID" value="ACK41812"/>
        <property type="gene ID" value="Dtur_0519"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0519"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZ79"/>
    <dbReference type="OMA" id="IRQKMQV"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="368" mass="42041" checksum="D5BA59FA4F444D2F" modified="2009-03-03" version="1">MREFNELRITGLNKYYGNKKVVDNFNLTIKNGEFVTLLGPSGSGKSTVLNCIAGLVPIDGGSIYIDDECLDDGKKFVPPERRNFGMVFQNYALFPHLSVFDNVAFGLKLRKLPKDIVKEKVIDALKMVHLEEHINKYPRQLSGGEQQRVALARCIVMEPRVMLLDEPLSNLDALSRIEMRYELKALHERLKITTIYVTHDQQEALALSDRIVVLNKGKIQQIGTPEEIYSYPANLFVANFLGFRNIWEVKISRFEGDREVHINLGNINLKAILHEKYKVHVRNIFENNKKPYISVRPEDIELGEGPENNIEVKIDVIEYLGQHKQFWGITSDGINIEISKDADISLKPGDNVKIWIPPERILVFSGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZA1</accession>
    <name>B8DZA1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582919.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352448.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0544"/>
    <dbReference type="EnsemblBacteria" id="ACK41834">
        <property type="protein sequence ID" value="ACK41834"/>
        <property type="gene ID" value="Dtur_0544"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0544"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.580"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_14_1_0"/>
    <dbReference type="InParanoid" id="B8DZA1"/>
    <dbReference type="OMA" id="CIVPRES"/>
    <dbReference type="OrthoDB" id="1431378at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="212" mass="24553" checksum="4FBB9366D3337CB3" modified="2009-03-03" version="1">MEIFNKYFKEYDWWYEENRWVYLSEVEVLRKVIPKGKKGLEIGVGTGRFAKELGIEYGIDPSEKMLSIAKERGIKGFVGRGESLPFSDKEFDYVALIITLCFVENPDNVIKESKRVLKDGGKIIIGIIDKNSSLGKLYLEKKKEGHKFYKYATFFSVDEVVDLLKRHDFRDFVFYQTLFKPLEEIKEIEEPKEGFGEGSFVVISAEKSGKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZA2</accession>
    <name>B8DZA2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582920.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352449.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0545"/>
    <dbReference type="EnsemblBacteria" id="ACK41835">
        <property type="protein sequence ID" value="ACK41835"/>
        <property type="gene ID" value="Dtur_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0545"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZA2"/>
    <dbReference type="OMA" id="ANYKERV"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="7"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="135" mass="15599" checksum="1D9F3562C08F7674" modified="2009-03-03" version="1">MDLPIDIKKKLKELNIGIIYLFGSTVLGIAKEHSDIDIGVVFIDPSVLEDVRLSLEIYNTLYGIFSTLFPKKEIDIVFLDKVPLTLKFEVVNSGEILYSISKDFLANYKERVLKEYIDFKPLMDEQDKILLKRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZB9</accession>
    <name>B8DZB9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582937.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352466.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0562"/>
    <dbReference type="EnsemblBacteria" id="ACK41852">
        <property type="protein sequence ID" value="ACK41852"/>
        <property type="gene ID" value="Dtur_0562"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0562"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="InParanoid" id="B8DZB9"/>
    <dbReference type="OMA" id="LMPWRSA"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="191" mass="22390" checksum="4F929BA31B94CFED" modified="2009-03-03" version="1">MVFLRVNNIKKSFDEKKVLDGVFMEVYKGERVIIKGPNGVGKTTLLKIIAGIILPDEGSIDFLVKPQISFQFQNVVFFPWLSMMENLELFVRDKEILKNLIEYFSLRDFFHLYPSEISGGYQQIFSFVRALSIPHNLLILDEPFKSLDPERKKRVKEVLKDHLKDRKITLLMVSHQEEEEREIADRIFNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZC4</accession>
    <name>B8DZC4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352471.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0567"/>
    <dbReference type="EnsemblBacteria" id="ACK41857">
        <property type="protein sequence ID" value="ACK41857"/>
        <property type="gene ID" value="Dtur_0567"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0567"/>
    <dbReference type="eggNOG" id="ENOG502ZJBI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1401861_0_0_0"/>
    <dbReference type="OMA" id="PECILRY"/>
    <dbReference type="OrthoDB" id="2098407at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="189" mass="23077" checksum="1B5C1D634E92AECC" modified="2009-03-03" version="1">MMGKLFRFIIINFDHFLSKIQGVKIFTDNPECILRYKLVRKKSKTFVELHLWNEHLPQIPSEGIDLFWGKRFQRLFFNSLKELLDFVERSSFSDVEWFMGEIAFFFKNQDKVVRFLKKLGFMVYPIEGRNIFQRFFIFLKNGYSFCLIYAYNPNSLRGKDFFSRKRYQLWIEKDKIRSVYEEAKKVYKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZM8</accession>
    <name>B8DZM8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pullulanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352575.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0676"/>
    <dbReference type="EnsemblBacteria" id="ACK41961">
        <property type="protein sequence ID" value="ACK41961"/>
        <property type="gene ID" value="Dtur_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0676"/>
    <dbReference type="eggNOG" id="COG4945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077116_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZM8"/>
    <dbReference type="OMA" id="NEYEGQH"/>
    <dbReference type="OrthoDB" id="1153156at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019248">
        <property type="entry name" value="Glucodextran_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09985">
        <property type="entry name" value="Glucodextran_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870558" evidence="1">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Glucodextran_C" evidence="2">
        <location>
            <begin position="28"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="267" mass="30211" checksum="5EEBD95BE7713450" modified="2009-03-03" version="1">MKKFLIFIFLILLSTLIFAEPVKYPLVFNDPTNDDKGPGTYTYPTDGVFKPGTFDMTKVVIDADNDNVYFKISFRVPIENPWGSPIGLSLQTIHIYIDKDHKKDSGFRDFIPGVRAQTTPESAWDLAILVEGWPTELKSSVKNAAPEMYKYCVFPSKGVTVDGNTIIIPVSKKTLGDDFQKGWGFQVFIMGQEGFPTQDPVSCRIREVLSTAQQWRFGGGDDFYGDPNIIDMLDYEGINQFEVLGKYKSDAKFEKNVYAQVPFIYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZP5</accession>
    <name>B8DZP5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Indole-3-glycerol-phosphate synthase</fullName>
            <ecNumber evidence="3">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583063.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352592.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0693"/>
    <dbReference type="EnsemblBacteria" id="ACK41978">
        <property type="protein sequence ID" value="ACK41978"/>
        <property type="gene ID" value="Dtur_0693"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0693"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.731"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZP5"/>
    <dbReference type="OMA" id="REIVWQK"/>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IGPS" evidence="6">
        <location>
            <begin position="27"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="258" mass="29180" checksum="FCE8B2E850C586C3" modified="2009-03-03" version="1">MNILDKLVEEKKKVIFNKIYKIPNSFPEKEKDYFYKVLSKDRFNIIGEIKPASPVKGKLLSLTVSEMARIYDGAKEISAISVLTAESFSASMNNLSLVRKITQKPLLQKDFILIPEQIYEGRLLGADAILLIARILSQSDIKALYNLCLRLDMEPIIEVYNEEDLEKVIDLKPRIIMINNRDLTSFKVDINNTLRLLPHIPADTFVISASGIKDGEEVKILYEHGVKGILVGESIVISQDPQKKIEELFEGCGLKSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZQ4</accession>
    <name>B8DZQ4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583072.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352601.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0702"/>
    <dbReference type="EnsemblBacteria" id="ACK41987">
        <property type="protein sequence ID" value="ACK41987"/>
        <property type="gene ID" value="Dtur_0702"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0702"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.740"/>
    <dbReference type="eggNOG" id="COG1318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1988958_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZQ4"/>
    <dbReference type="OMA" id="KPEYAQM"/>
    <dbReference type="OrthoDB" id="1419738at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022285">
        <property type="entry name" value="CHP03879_regulat_dom_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03879">
        <property type="entry name" value="near_KaiC_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="127" mass="14396" checksum="7CA2AF5104067236" modified="2009-03-03" version="1">MPILSGDEIPIKEDELDSLAMKTFLKTLDILGGPRKLILYRNLTWVPSLIEACYAVILRDRYMKTEAEIAEFLGLTKQTVRNILKADPDIVLDVLEDELKKKEIKTHVAGGLAKLAYRKVKEELGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZQ7</accession>
    <name>B8DZQ7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583075.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352604.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0705"/>
    <dbReference type="EnsemblBacteria" id="ACK41990">
        <property type="protein sequence ID" value="ACK41990"/>
        <property type="gene ID" value="Dtur_0705"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0705"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026152_3_1_0"/>
    <dbReference type="InParanoid" id="B8DZQ7"/>
    <dbReference type="OMA" id="NKTILFP"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="179"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="379" mass="44417" checksum="B7D413DA6C7E0842" modified="2009-03-03" version="1">MVYLLLFLILIGILLNELSKRYILDKVYFNRNFSKRVAEIAEDIYIEVVVENRKLIPVTFLQVIQELPSVIEYKFQVNKVRTKDFLYHTMTFFLLPYQRIKRKYLATCTKRGRYVFGNVELCGGDFLGLNLKTKSISLVQDLVVLPKRKDLEKDLIPYGNFNGDTSVKRWIIEDPTMIIGVKDYTGREPAKTIHWPLSLKHNKILVKNFDFTYENNAMIFLNVECSKPYWIKMDEKSIEECISVARSVGEIFHERKIPFGFTTNSLIYGFSRDENTVYPGMGDAHLQLFLEYLGRLSYNVNVPFEEVIKAFMRNNNFMISTYVIITPYLLREYIPYISALDTDLTKVILITYYDDNLSFLSPKILKYSLRREKNVASIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZU6</accession>
    <name>B8DZU6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583114.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352643.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0747"/>
    <dbReference type="EnsemblBacteria" id="ACK42029">
        <property type="protein sequence ID" value="ACK42029"/>
        <property type="gene ID" value="Dtur_0747"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0747"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_9_0"/>
    <dbReference type="InParanoid" id="B8DZU6"/>
    <dbReference type="OMA" id="RSGFEIC"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="121" mass="13552" checksum="9C344AE5794B8D0D" modified="2009-03-03" version="1">MKKILIVEDEENVRGLIKETLGFLNKYEIHEAGTGREALEKIKELNPDLVILDIMLPDIDGYTICEQIKEDPSLNSLVLILTARSSNLDKKVGFSMGADDYMTKPFGLADLITRVENLLGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZW1</accession>
    <name>B8DZW1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583129.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352658.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0762"/>
    <dbReference type="EnsemblBacteria" id="ACK42044">
        <property type="protein sequence ID" value="ACK42044"/>
        <property type="gene ID" value="Dtur_0762"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0762"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.800"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_0"/>
    <dbReference type="InParanoid" id="B8DZW1"/>
    <dbReference type="OMA" id="EFWILLK"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="458" mass="50045" checksum="404A57CC6375F032" modified="2009-03-03" version="1">MLEDERGKIGKRVLALAIPVLLENLFQLVFSFVDMIFVGFLGAVALAAVGLGMQVINVILAIIASLTVGTMVTVAYSVGAKKHNDAARYLENSLVLGFYLSILILLFGLFGTDKLLQILGAKGELLYNSSLYLKYILIPSFLIVYMSIISSALRGSGDTKTPLYVSIVSNALNIFLDYVFVFGKFGFPKMGVAGAALATTLSRLLGMVILFYIIYKRNDFLSCKFSCKIVPEKDVSTQILKIGIPTSLEQLLFNMGALLYATIVLSLGTKVYAAHRIALNVESLSFQPGFAFGVAATTLVGQYKGAREDDLARLASIESWRKAVIFMGSVGVLLFFFPEYLVQIFTRDMEVIKCASSVLKIIAVIQPLLATANVMSGSLRGAGFSKIPMVISGVGMWSIRIPLAYVLALKMGLGLTGAWIAMATDISLKAVANYYMFIIKKYYKKESFKLRYEEAISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZX3</accession>
    <name>B8DZX3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583141.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352670.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0774"/>
    <dbReference type="EnsemblBacteria" id="ACK42056">
        <property type="protein sequence ID" value="ACK42056"/>
        <property type="gene ID" value="Dtur_0774"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0774"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.811"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_0"/>
    <dbReference type="InParanoid" id="B8DZX3"/>
    <dbReference type="OMA" id="DVFEMND"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="61" mass="6209" checksum="FDC70A87C044B782" modified="2009-03-03" version="1">MSAPKVDRDLCIGCGVCASLCPDVFEIDEEGKAIVREGADCESAGCCQDAADSCPVGAITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZY1</accession>
    <name>B8DZY1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ordered locus">Dtur_0783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583149.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352678.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0783"/>
    <dbReference type="EnsemblBacteria" id="ACK42064">
        <property type="protein sequence ID" value="ACK42064"/>
        <property type="gene ID" value="Dtur_0783"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0783"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.822"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_0"/>
    <dbReference type="InParanoid" id="B8DZY1"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="39"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="98"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="313" mass="34520" checksum="7EF237D2C36016FA" modified="2009-03-03" version="1">MGQRCLALYSGTSNRELAEEVAKYLGIELGEIEIRRFSDGEIYARIAKSVRGAEVYVIQSLGSKVNEYFMELLIIIDALKRASADEVTAVIPYYAYARQDRKTKSREPISAKLIANLLTVAGASRVVTMDLHAGQIQGFFDIPVDNLSALPLFTRYFQDKNLKNPVVVSPDIGGVTRARALADRLHTPLAIIYKRRPAPEVAEVEEIIGEVEGRDVIICDDIVTTGNTLFSAAKLLKLKGARDIYAAVTHGILTNDAHKKLQESEIKELVVTNTIPIPLEKRVPKLTIISIGNLLGEAIKRISNKDSLSSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZY9</accession>
    <name>B8DZY9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583157.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352686.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0791"/>
    <dbReference type="EnsemblBacteria" id="ACK42072">
        <property type="protein sequence ID" value="ACK42072"/>
        <property type="gene ID" value="Dtur_0791"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0791"/>
    <dbReference type="eggNOG" id="ENOG5032T5C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084188_0_0_0"/>
    <dbReference type="OMA" id="QIDECCQ"/>
    <dbReference type="OrthoDB" id="1022304at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="259" mass="31175" checksum="6858DD2F9368A9A4" modified="2009-03-03" version="1">MEAVSLEEIKLFFWRRGYQIDECCQKERIILPKDLSLEGDYFNFLSHYRFRRLLSDIIHSQDNGRVNLEKLFSRWNLEEIREYWEFLVKSGILTLVNENYYFSYPYIDNFGETLEWYISGLLVKEFKMPTVWGVKIRELKGGGDFDVLSILEGYLLYIECKTSPPNNVRLREIWEFLRRREELKPKITILFIDTTLKIERNITENVKYLLDKRFAKDKNNVLLKLKEGIYAFDKSLYIMQSKGEMVKNFQLVFRDFLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZZ8</accession>
    <name>B8DZZ8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stage V sporulation protein S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012548757.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352695.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0800"/>
    <dbReference type="EnsemblBacteria" id="ACK42081">
        <property type="protein sequence ID" value="ACK42081"/>
        <property type="gene ID" value="Dtur_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0800"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.838"/>
    <dbReference type="eggNOG" id="COG2359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168904_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZZ8"/>
    <dbReference type="OMA" id="IGIEIAC"/>
    <dbReference type="OrthoDB" id="1985350at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007347">
        <property type="entry name" value="SpoVS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35331">
        <property type="entry name" value="PTHR35331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04232">
        <property type="entry name" value="SpoVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="87" mass="9086" checksum="DCCB4EDC80717AE0" modified="2009-03-03" version="1">MVEVLKVSAKSNPNAVAGALAGVIREKGRAEIQVIGAGAVNQAVKAIAITRGYVAPSGIDLICIPAFTDVQIDGEERTAIRFIVEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E034</accession>
    <name>B8E034_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583201.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352731.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0836"/>
    <dbReference type="EnsemblBacteria" id="ACK42117">
        <property type="protein sequence ID" value="ACK42117"/>
        <property type="gene ID" value="Dtur_0836"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0836"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613550_0_0_0"/>
    <dbReference type="InParanoid" id="B8E034"/>
    <dbReference type="OMA" id="YNAKQQL"/>
    <dbReference type="OrthoDB" id="2106566at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990281">
        <property type="term" value="C:efflux pump complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="338"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="446" mass="51370" checksum="97CA0A89AA8DAE15" modified="2009-03-03" version="1">MYKKTVFYLLLILIFIVTLSFSEDYLTLESLKPLLIKSPLYKIYQVQYNNALQEYNLAYSNLKPQLSLQFSYNQGETSVTLNNVTSMSETKSGNLSLSFSQVLFLKGQAGISIKLAELNLEQEKNNFKTNCQNLYYQFIQSFYNLYLAQEQLKIYEESYNLSKKQEEVAEKQFKDGVINEITLLDYKQKAKLAEINYNSAKNNLELSYKSLENLLGTTLPRVPVKLDVNYEPITYSADELISRLYSNNLTIKNSTLDLEKAKVNLEKANLPSWNIGISGSYSSGNITYALSFDTQNYALNASVSPSWSTSQKSTENIWNFKISFSTPILDGGSKNITKSQAQISLDQAQINYEKTKKDVELNFWKTYYNLLTAQETIEQKKLLLEQKKTNLEAQKIRYNLGLITDLDLKNYEIDYMQAQYDLKNAILNFNLQKIQLDILLGNWEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E039</accession>
    <name>B8E039_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycerol kinase</fullName>
            <ecNumber evidence="5">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glycerokinase</fullName>
            <shortName evidence="5">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glpK</name>
        <name evidence="9" type="ordered locus">Dtur_0841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="5">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352736.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0841"/>
    <dbReference type="EnsemblBacteria" id="ACK42122">
        <property type="protein sequence ID" value="ACK42122"/>
        <property type="gene ID" value="Dtur_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0841"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.880"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_0"/>
    <dbReference type="InParanoid" id="B8E039"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="7">
        <location>
            <begin position="2"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="8">
        <location>
            <begin position="257"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="240"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="406"/>
            <end position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="494" mass="55629" checksum="A264A8B7934BB473" modified="2009-03-03" version="1">MYILALDQGTTSSRAIIFDQLGNVISVAQKEFPQIFPKSGWVEHNPWDIWNSQREVMIEAIEKAKIKPKEISTIGVTNQRETTIVWDKHTGQPIYNAIVWQCRRTADYCEELKRNGLSEVIKEKTGLVIDAYFSGPKIKWILDNVPEAREKAEEGRLLFGTVDTWLIWNLTGGKVHATDYTNASRTMLFNIKNLDWDDELLEIMNIPRSMLPKTFPSSYFYGVCNIFDGVEIPITGIAGDQQAALFGQCGFEEGVVKNTYGTGCFILLNTGENIKYSSKGLITTIAYGIGEKVNYALEGSIFIAGAVIQWLRDNLGLIKSSSESEILAKMVEDNGGVYFVPAFVGLGAPYWDMFARGLIIGLTRGAKKEHLVRAALESIAYQTNDVVELMEQETGIKIKELRVDGGASANNFLMQFQSDISNLKVIRPYITETTSLGAAFLAGLGVGIWKDLDEIKRIWKEEKVFTPCMPEEKRRYYLSKWKEAVNRSRGWDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E049</accession>
    <name>B8E049_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583216.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352746.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0851"/>
    <dbReference type="EnsemblBacteria" id="ACK42132">
        <property type="protein sequence ID" value="ACK42132"/>
        <property type="gene ID" value="Dtur_0851"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0851"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.890"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_0"/>
    <dbReference type="InParanoid" id="B8E049"/>
    <dbReference type="OMA" id="LWPASIH"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="303" mass="33960" checksum="EF2E399E34914197" modified="2009-03-03" version="1">MNNNTKIQFKVVTDSTADIPEEISKELEIEVIPYYIHLQEKAFQENVDITPEYIWNYMENLEDLSKLPKTACPGVGEYYEAFKKILEKGKKVLSIHMTSWGSGAFQSANTAKQILKEENPNYEIEVIDSKSVSLGTGFMVIEAAKASLNGWNIKETIKHISKIRENLFHAFTNDTLKFLAAGGRIGKAQYLLAEVLKINPIISVNPEGVLVALDKAVGRLKTYQRIVSHMQDFFKDNKVLNVGFLHANAMEEINKIKEEISKVFELRDIIVNKLSAALSVHSGPGTIGVIAYPLSLSLDIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E053</accession>
    <name>B8E053_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Maltose/maltodextrin transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583220.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352750.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0855"/>
    <dbReference type="EnsemblBacteria" id="ACK42136">
        <property type="protein sequence ID" value="ACK42136"/>
        <property type="gene ID" value="Dtur_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0855"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.894"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_20_1_0"/>
    <dbReference type="InParanoid" id="B8E053"/>
    <dbReference type="OMA" id="FWAKVAV"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990060">
        <property type="term" value="C:maltose transport complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015423">
        <property type="term" value="F:ABC-type maltose transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042956">
        <property type="term" value="P:maltodextrin transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032605">
        <property type="entry name" value="DUF4896"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030156">
        <property type="entry name" value="MalF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035277">
        <property type="entry name" value="MalF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032550">
        <property type="entry name" value="TM_PBP2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47314:SF1">
        <property type="entry name" value="PTHR47314:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16237">
        <property type="entry name" value="DUF4896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16296">
        <property type="entry name" value="TM_PBP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="337"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="575" mass="66714" checksum="B5FF1589BB47BF38" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0A9</accession>
    <name>B8E0A9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ThuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583636.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353168.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1276"/>
    <dbReference type="EnsemblBacteria" id="ACK42554">
        <property type="protein sequence ID" value="ACK42554"/>
        <property type="gene ID" value="Dtur_1276"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1276"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1316"/>
    <dbReference type="eggNOG" id="COG3828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105364_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0A9"/>
    <dbReference type="OMA" id="IAGWWHN"/>
    <dbReference type="OrthoDB" id="1452706at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029010">
        <property type="entry name" value="ThuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06283">
        <property type="entry name" value="ThuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThuA" evidence="1">
        <location>
            <begin position="69"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="206" mass="24396" checksum="AB0C4D924F65B848" modified="2009-03-03" version="1">MERVLAIVGDYYHPEEKIKETLEFVLKNTYWVDYASINNFSMLIREDPYLVIIGRENKLNPQDKNSLIWMDDEIENLLVDYVSNGGRLLVMHSGLASYDVSGKYVRELTRGYFKYHPERKMVKYYGRYPDKDKDIYFEIFDEHYFVEVDKESTNIFLYSTSLDGESVAGWYHEYGKGKILCLTPAHNEALANENLRKLLRDLILWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0E7</accession>
    <name>B8E0E7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Dtur_1318</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583674.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353206.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1318"/>
    <dbReference type="EnsemblBacteria" id="ACK42592">
        <property type="protein sequence ID" value="ACK42592"/>
        <property type="gene ID" value="Dtur_1318"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1318"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1363"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_0"/>
    <dbReference type="InParanoid" id="B8E0E7"/>
    <dbReference type="OMA" id="RRFVQMY"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="19"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="302"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="420"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="516"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="836"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="749"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="770"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="771"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="889" mass="98643" checksum="0B0D0E37759CBCC4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0F2</accession>
    <name>B8E0F2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">era</name>
        <name evidence="12" type="ordered locus">Dtur_1323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8 9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353211.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1323"/>
    <dbReference type="EnsemblBacteria" id="ACK42597">
        <property type="protein sequence ID" value="ACK42597"/>
        <property type="gene ID" value="Dtur_1323"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1323"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1368"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0F2"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Era-type G" evidence="11">
        <location>
            <begin position="6"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="10">
        <location>
            <begin position="197"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="8">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="8">
        <location>
            <begin position="40"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="8">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="8">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="8">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="298" mass="34261" checksum="A5827B9538B8015F" modified="2009-03-03" version="1">MMGKTKLAYISIVGKPNAGKSTLINLLVGEKVSIVADKPQTTRQRILGVLTLEDAQFIFLDTPGWFPPKHLLGEYMQKTIKKTIEDSDIVLYVIDSSVELDDDNRTLLKFVKDQGKPYLVLLNKIDMVSSKSIEERKKEVIALGVSEEKIIEISALYGTNKELLIEKLKEIAPEGEFLYPPDMLTDQTDKFFIAEIIREKIIHLTYQEVPHSVAVYVDDIEEKKDGNLLYIRATIIVERPTQKAIIIGKDGQMLKKIGTLARMEIESYYQKQVYLDLWVKVREKWRKKPEILRELGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0J5</accession>
    <name>B8E0J5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 16">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">Dtur_1366</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 16"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583720.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353254.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1366"/>
    <dbReference type="EnsemblBacteria" id="ACK42640">
        <property type="protein sequence ID" value="ACK42640"/>
        <property type="gene ID" value="Dtur_1366"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1366"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1411"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0J5"/>
    <dbReference type="OMA" id="LMFYGPG"/>
    <dbReference type="OrthoDB" id="1464088at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 16" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="18">
        <location>
            <begin position="345"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ACK42640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="424" mass="47818" checksum="3BF041BE528F2876" modified="2009-03-03" version="1">MKIGILGGGQVGQALWDTIHMEKENILNILGEPLEIKKVLVRDLSKKRDIPKDFLTNNPDEIIYDKEISLIVEVMGGEEPAHTYIKRALEEKKFVVTANKEVIALHGDELHKIARKKGVDIAFEASVGGGIPLIKTIKEAMAVDKVKEIWAIVNGTTNYILTKMEEELRDFEEVLREAQKLGYAEPDPSKDILGLDTKFKLAILSSFAYHTTIKPEEIYTEGIEKISLRDIQYAKELGYKIKLLAISKFYNGEIEVRVHPTMIPLSSPLSSVNGVYNAILLRAEKRGDVLLYGEGAGPYPTAMALLSDILEATHTILYSVPRYYSFAYLYPSKIKPSDEIYTRYYIRLWVKDQPGVLAQIAKILGENHISISSVIQKETSEKEGKAELVILTHKTYEKSMSKAIEEIKLLPILEEWGSLIRIEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0K3</accession>
    <name>RL11_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplK</name>
        <name type="ordered locus">Dtur_1374</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012548197.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353262.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0K3"/>
    <dbReference type="SMR" id="B8E0K3"/>
    <dbReference type="STRING" id="515635.Dtur_1374"/>
    <dbReference type="EnsemblBacteria" id="ACK42648">
        <property type="protein sequence ID" value="ACK42648"/>
        <property type="gene ID" value="Dtur_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1374"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1419"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_0_0"/>
    <dbReference type="InParanoid" id="B8E0K3"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000195625" description="50S ribosomal protein L11">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <sequence length="142" mass="15186" checksum="DF5928D5742542A3" modified="2009-03-03" version="1">MPKKVVGKVKLQLPAGKATPAPPVGPALGQYGVNIMEFCKAYNAATAGQEGMIIPVEITIYEDRSFTFVTKTPPASDLLKKAAGVEKGSGEPNKVKVGKVKRSKIREIAELKMKDLNANDIEAAMRMIEGTARSMGIEIIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0L6</accession>
    <name>B8E0L6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1764</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584111.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353650.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1764"/>
    <dbReference type="EnsemblBacteria" id="ACK43036">
        <property type="protein sequence ID" value="ACK43036"/>
        <property type="gene ID" value="Dtur_1764"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1764"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1816"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="InParanoid" id="B8E0L6"/>
    <dbReference type="OMA" id="QSGNLIP"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK43036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="248" mass="28487" checksum="B14E0E6F34C7E2A0" modified="2009-03-03" version="1">MDGSKILFKLVDVSFYYVSERLALNSISLEIKEGESIGILGPNGSGKSTLLKILDGLLFPQEGKVFFEGRELREKSFEDPNFNRYFRKKVVLLFQNVDAILFSPTVRDELAFGLLQLGYSDSEIERKIYECSRKFRIENLLKRSPFQLSEGEKKKVALASLLIIEPDIILLDEPTNELDPRSVRELLSYIKELRAAGKTIITATHDLQMVNGFFDRIFVMNEEKKILKVGDYKTIFSDKEFLKEVNLI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0N8</accession>
    <name>ARGC_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC</name>
        <name type="ordered locus">Dtur_1786</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584132.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353672.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0N8"/>
    <dbReference type="SMR" id="B8E0N8"/>
    <dbReference type="STRING" id="515635.Dtur_1786"/>
    <dbReference type="EnsemblBacteria" id="ACK43058">
        <property type="protein sequence ID" value="ACK43058"/>
        <property type="gene ID" value="Dtur_1786"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1786"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1838"/>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0N8"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="OrthoDB" id="951261at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000118059" description="N-acetyl-gamma-glutamyl-phosphate reductase">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <sequence length="336" mass="37939" checksum="C339E577BDB5F447" modified="2009-03-03" version="1">MLKVGIVGASGYVGLELTRILLRHPQVDKLYLFSDHFEDSWVFKSEKIFITDRSTYSELYKDLDVVFFALGSGETLGFLSKGEIPERFIDMSADFRFKNPGEYERVYGIKHNMPEILEKVVYGLPEIFRDKIKGAQYIANPGCYPTASLLGLFPLIKNNLTYGNAIIDAKSGISGAGRKPTDKSIYGNIAENYQAYSILNHRHQPEIENVIKEIGYLRVLFVPQLIPVFRGMFVSIYVPLRDEITSEDLYQIFKEVYEDEYFIKVLPPSCSPEIKKVRGTNWAVISAQADKNTKNAVILVAIDNLIKGAAGQAIQNMNIMFGFAESLGLDFLPLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0R6</accession>
    <name>B8E0R6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA binding S1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583731.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353267.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1379"/>
    <dbReference type="EnsemblBacteria" id="ACK42653">
        <property type="protein sequence ID" value="ACK42653"/>
        <property type="gene ID" value="Dtur_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1379"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_2_2_0"/>
    <dbReference type="InParanoid" id="B8E0R6"/>
    <dbReference type="OMA" id="SLNEFRY"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="19"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="105"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="193"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="279"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="363"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="449"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="552" mass="63915" checksum="99ED990CAD47345C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0S6</accession>
    <name>B8E0S6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="10">ACCase subunit alpha</shortName>
            <shortName evidence="10">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="10">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">accA</name>
        <name evidence="12" type="ordered locus">Dtur_1389</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583741.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353277.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1389"/>
    <dbReference type="EnsemblBacteria" id="ACK42663">
        <property type="protein sequence ID" value="ACK42663"/>
        <property type="gene ID" value="Dtur_1389"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1389"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1436"/>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_0"/>
    <dbReference type="InParanoid" id="B8E0S6"/>
    <dbReference type="OMA" id="TPWQRVQ"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="272" mass="30313" checksum="7A4D7FBC936A3C40" modified="2009-03-03" version="1">MVNKLSPWERILIARHPKRPTFTDFLNELFDNFLELHGDRLFGDDPAIIAGFGSFENESVVIIGQEKGKSIQEKMKRNFGMPHPEGYRKALRVMKLAEKFSLPVISFIDTAGAYPGIGAEERGQAWAIANNLKEMSLLETPIIVVVLSEGGSGGALGIGVGDYIMILENAYYSVISPEGCASILFRDSSKAPEAAEALKITSEDLLKLGLVDEIIPEPNGGAHEDFLGTVENLRKALSRVLKKYKNKETRVLLEERWIKLRSYGRFVEEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0T8</accession>
    <name>B8E0T8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein 2</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1401</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583753.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353289.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1401"/>
    <dbReference type="EnsemblBacteria" id="ACK42675">
        <property type="protein sequence ID" value="ACK42675"/>
        <property type="gene ID" value="Dtur_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1401"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1448"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_0"/>
    <dbReference type="InParanoid" id="B8E0T8"/>
    <dbReference type="OMA" id="SCDTYYY"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PBP_dimer" evidence="3">
        <location>
            <begin position="48"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="246"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="574" mass="64950" checksum="CA2645DE3EA11709" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0W0</accession>
    <name>B8E0W0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Adenylosuccinate lyase</fullName>
            <shortName evidence="10">ASL</shortName>
            <ecNumber evidence="4 10">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_1423</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583775.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353311.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1423"/>
    <dbReference type="EnsemblBacteria" id="ACK42697">
        <property type="protein sequence ID" value="ACK42697"/>
        <property type="gene ID" value="Dtur_1423"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1423"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1470"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0W0"/>
    <dbReference type="OMA" id="ASSCEKI"/>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="12">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="435" mass="50842" checksum="AA10111A295F9595" modified="2009-03-03" version="1">MLLRYSRKELREIWSDEHRYFLWWKVEEAVLEARAKFGEIPYEILKKIKEKARFSVEEIIEIEKENNHEMIAFLTNVAQYVGEGSEYIHQGLTSSDVMDTAFSLQIIEALNLIEDDLKRLMEEIKKKAIQYKNLPMMGRTHGMHAEPITLGFKFLSWWSELKRDLERLRVAKENISFGKFSGVVGTLAHLSPKIEEEACKILGLKPEPVATQVIPRDRHAEVIYALSMIASTCERIALEIRHLQKTEVGELEEPFREKQKGSSAMPHKRNPVLSERICGLSRVIRGYINSALENIPLWHERDISHSSVERVIFPDSTSLTDYILNLLIGIINNLRINEERIKENMSMNYRIYYSQNLLLALTEKGVLRDVAYGWVQEDAFRAVEQKRDFMDIVLEDNRIREYLSEEEIKQCFSPEVFLKNIDVIFERSGIYKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0W7</accession>
    <name>B8E0W7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583782.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353318.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1430"/>
    <dbReference type="EnsemblBacteria" id="ACK42704">
        <property type="protein sequence ID" value="ACK42704"/>
        <property type="gene ID" value="Dtur_1430"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1430"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1477"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_2_8_0"/>
    <dbReference type="InParanoid" id="B8E0W7"/>
    <dbReference type="OMA" id="WQGINLE"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="300" mass="33991" checksum="0632C1D5AF6D61C0" modified="2009-03-03" version="1">MFKKRALKLIISIVILIFIFSISFSKTLPITLKDDLGRTIVINKYPERIISLAPSSTEILFSIGAGDKVIGVTDFCNYPKEALTKEKVGGFSNPNVEKIISLKPDLVVLYKSFPKEVFIQLEKNLPDTNFIVLDPKTYEDVMKNIILIGKAVGKEEEARRVYNNMLKTWLEIQKKTISIKKSPKILFLVWNDPFISVSPSTFLGDLIKKLKAINIVENKEPEYPVLSIEFIVSKNPDLIIIGEMSGISINSILNHPLLRETNAAKNKRVYLINDDLVFRPGPRLAEGLKELFKIVYPNLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0X7</accession>
    <name>DEF_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide deformylase</fullName>
            <shortName evidence="1">PDF</shortName>
            <ecNumber evidence="1">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">def</name>
        <name type="ordered locus">Dtur_1440</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583792.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353328.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0X7"/>
    <dbReference type="SMR" id="B8E0X7"/>
    <dbReference type="STRING" id="515635.Dtur_1440"/>
    <dbReference type="EnsemblBacteria" id="ACK42714">
        <property type="protein sequence ID" value="ACK42714"/>
        <property type="gene ID" value="Dtur_1440"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1440"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1487"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_4_2_0"/>
    <dbReference type="InParanoid" id="B8E0X7"/>
    <dbReference type="OMA" id="VCIQHEI"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043686">
        <property type="term" value="P:co-translational protein modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031365">
        <property type="term" value="P:N-terminal protein amino acid modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018206">
        <property type="term" value="P:peptidyl-methionine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000200725" description="Peptide deformylase">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <sequence length="153" mass="17293" checksum="8E70201301634A77" modified="2009-03-03" version="1">MIMEIRKIGDPILKIKAKKVEKIDEKVKNLVRDMIETMKFSNGVGLAAPQVGESLRIIVVDYEENPIAFINPEILEMDGEVLDYEGCLSVPGVEVPIKRAERIIFKAQDLQGRTKRYKAKGLLARVIQHEVDHLEGILILDRAVEESTLAEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Y2</accession>
    <name>B8E0Y2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1445</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353333.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1445"/>
    <dbReference type="EnsemblBacteria" id="ACK42719">
        <property type="protein sequence ID" value="ACK42719"/>
        <property type="gene ID" value="Dtur_1445"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1445"/>
    <dbReference type="eggNOG" id="COG1561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076609_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0Y2"/>
    <dbReference type="OMA" id="EIKSVNH"/>
    <dbReference type="OrthoDB" id="1509828at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="198"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="282" mass="33818" checksum="2F6479EB32666E88" modified="2009-03-03" version="1">MTASAFRELSIDSLNFFLEVKGYNHRFLEIKINLPDTLSSIEKEIAREIKKFVKRGFILFSIKITKDHLTNYKINVPLIMNILEEIGRITGKEENIWDWKEILANPQIFYVENRFFRDEDFSNLLTETKILLEEFNRIREEEGKSIFEALERSLDKIESLLFLIKKEEGKWQKEAKEFLERKLKEFNFKDIDENRLYQELSLLLMKTDINEEIIRIEEFVRRFKNEMKKEESIGKTLEFIVQEIHREVNTLSSKTAKTSVMFYAVDIKNELEKIRELILNVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Z1</accession>
    <name>B8E0Z1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583806.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353342.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1454"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42728">
        <property type="protein sequence ID" value="ACK42728"/>
        <property type="gene ID" value="Dtur_1454"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1454"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1503"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023978_2_2_0"/>
    <dbReference type="InParanoid" id="B8E0Z1"/>
    <dbReference type="OMA" id="RNRWAEG"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="399" mass="45614" checksum="8E86D3714553138A" modified="2009-03-03" version="1">MFTLNRAFGEQRLGYQDIIDSDLPYVSVLVPMHNEEKVAENVLNALLNTDYPKDRIEIIPIDDNSTDRTREILEDYSSKYPHLIKPLYRGSYLPRGKPSALNDALKVAEGEIIIVFDADYIPPKGIIRDLAVSFLDPEVGVVMGRVVPLNISKNLLTRLFDLERIGGYQVDQQARYNLKLIPQFGGTVGGFRKELILKLGGFNPKILAEDTELTIKAYINGVKVCYTNRAECYEEAPETWEVRAKQIRRWSRGHNQVMFRYLLPLIKSPYLSLREKVDGVFLLCVYLISPLFLIGLVDSIVLFFLGEMQILGSSFFIFLSAYNTFGNFAPFYEIGLGALLDGATYRIFLLPLPLFNFFFNMWYSSLGFFDSVLDLITRRDPVWHKTERFRNGGDVNCCS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E121</accession>
    <name>PDXS_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase subunit PdxS</fullName>
            <shortName evidence="1">PLP synthase subunit PdxS</shortName>
            <ecNumber evidence="1">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pdx1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxS</name>
        <name type="ordered locus">Dtur_1484</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">In the presence of PdxT, forms a dodecamer of heterodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583836.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353372.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E121"/>
    <dbReference type="SMR" id="B8E121"/>
    <dbReference type="STRING" id="515635.Dtur_1484"/>
    <dbReference type="EnsemblBacteria" id="ACK42758">
        <property type="protein sequence ID" value="ACK42758"/>
        <property type="gene ID" value="Dtur_1484"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1484"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1533"/>
    <dbReference type="eggNOG" id="COG0214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055352_1_0_0"/>
    <dbReference type="InParanoid" id="B8E121"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="OrthoDB" id="784095at2"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016843">
        <property type="term" value="F:amine-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PTHR31829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00343">
        <property type="entry name" value="TIGR00343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_1000188225" description="Pyridoxal 5'-phosphate synthase subunit PdxS">
        <location>
            <begin position="1"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="236"/>
            <end position="237"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01824"/>
        </source>
    </evidence>
    <sequence length="295" mass="31819" checksum="6FB7787305D2B01F" modified="2009-03-03" version="1">MQVFTGTDKVKRGLAQMLKGGVIMDVTNAEQAEIAEEAGAVAVMALERVPADIRAEGGVARMADPKKIKEIMSAVSIPVMAKVRIGHFVEAQILEALGVDFIDESEVLTPADEKYHINKHAFKVPFVCGARDLGEALRRIAEGAAMIRTKGEAGTGNVVEAVRHMRQIMDEIRSLVLLPDEELVAKAKELGAPLDLIIETKKLGRLPVVNFAAGGIATPADAALMMHLGADGVFVGSGIFKSKNPRKRARAIVLAVTYYDDPYVLAEISEDLGEPMPGIDVRKLSESELLQVRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E122</accession>
    <name>B8E122_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="10" type="ordered locus">Dtur_1485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583837.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353373.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1485"/>
    <dbReference type="EnsemblBacteria" id="ACK42759">
        <property type="protein sequence ID" value="ACK42759"/>
        <property type="gene ID" value="Dtur_1485"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1485"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1534"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_0"/>
    <dbReference type="InParanoid" id="B8E122"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="18"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="205"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="256"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="598" mass="70319" checksum="8FE974928251ECD1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E144</accession>
    <name>B8E144_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583256.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352786.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0891"/>
    <dbReference type="EnsemblBacteria" id="ACK42172">
        <property type="protein sequence ID" value="ACK42172"/>
        <property type="gene ID" value="Dtur_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0891"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.929"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099824_3_0_0"/>
    <dbReference type="InParanoid" id="B8E144"/>
    <dbReference type="OMA" id="WRIIGTG"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="174" mass="20360" checksum="116DE1E7DBDB065F" modified="2009-03-03" version="1">MEDILNEMVLVLNSNYEPLDVCKVKRAIILIMQKKAETIETNSGVIKSASMEIEVPSVIRLLYYVKRPRLELKLSRKGIFLRDNYTCQYCGKKGGELTIDHVIPKRLGGKSVWENLVTACKECNHKKGDKTLEEANMKLLREPKPPKNVHYFRLTRYLDYDKNEGWKKYFFIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8E147</accession>
    <name>B8E147_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583259.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352789.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0894"/>
    <dbReference type="EnsemblBacteria" id="ACK42175">
        <property type="protein sequence ID" value="ACK42175"/>
        <property type="gene ID" value="Dtur_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0894"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="InParanoid" id="B8E147"/>
    <dbReference type="OMA" id="PRNMYDK"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="370" mass="41226" checksum="D4396E9273772794" modified="2009-03-03" version="1">MAEVKLENVTKRFGDVIAVNNVNLEIKDKEFIVLVGPSGCGKTTTLRMIAGLEEVTSGNIYIDGKVVNDVPPKDRDIAMVFQNYALYPHMTVYDNMAFGLKLRKYPKSEIDRRVKAAAEMLGIENLLKRKPKELSGGQRQRVALGRAIVREPKVFLMDEPLSNLDAKLRVQMRAELKKLQRTLGVTTIYVTHDQTEAMTMGDRIVVMKDGVVQQVDDPLIVYEKPNNVFVAGFIGSPPMNFIDATLSSDAKILDLGSFKLGIPADMQGFVAEQAKNYLGKKVILGVRPEHIYEVSLIKTEDLIPEAVADMRVEVLEPMGTEVYLYLINGPVSVVARVGSETKARMGENVKVMFDLRKMHLFDPVSQVAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E148</accession>
    <name>B8E148_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583260.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352790.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0895"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42176">
        <property type="protein sequence ID" value="ACK42176"/>
        <property type="gene ID" value="Dtur_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0895"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.933"/>
    <dbReference type="eggNOG" id="COG1543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008192_1_0_0"/>
    <dbReference type="InParanoid" id="B8E148"/>
    <dbReference type="OMA" id="CAYYEGL"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037090">
        <property type="entry name" value="57_glycoside_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015293">
        <property type="entry name" value="BE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09210">
        <property type="entry name" value="DUF1957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="3">
        <location>
            <begin position="8"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1957" evidence="4">
        <location>
            <begin position="415"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="520" mass="62164" checksum="46C22D111A6153A2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E160</accession>
    <name>HTPX_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protease HtpX homolog</fullName>
            <ecNumber evidence="1">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpX</name>
        <name type="ordered locus">Dtur_0907</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583272.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352802.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E160"/>
    <dbReference type="SMR" id="B8E160"/>
    <dbReference type="STRING" id="515635.Dtur_0907"/>
    <dbReference type="EnsemblBacteria" id="ACK42188">
        <property type="protein sequence ID" value="ACK42188"/>
        <property type="gene ID" value="Dtur_0907"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0907"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_3_0_0"/>
    <dbReference type="InParanoid" id="B8E160"/>
    <dbReference type="OMA" id="AVCCTEG"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0482">Metalloprotease</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000203972" description="Protease HtpX homolog">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <sequence length="304" mass="34628" checksum="979487CE088DC71D" modified="2009-03-03" version="1">MKPFTFYEAIESNKRKTWFIVFIIYFLLFFVCYAVVSYFELGEIGIIIAFLIVLFTNYYAYQKSNEIILNYSGVREPTREEYPYLLNVVEGLSIAAGIPTPKIYIMDDPSPNAFATGKDPQNSVVVVTKGLLDILNRTELEGVIAHEISHIKNYDVRLQTIAAVMVGLIVILGDGLKRSFYYSKRRRDKDENILGIVSLIIAILAPFLATLLRFALSRQREYMADASAAMLTRYPEGLASALEKIAKNFQPIKRANVMTAPLYIVNPLSSNAVSKLFSTHPPIEERIRRLRMMGERWKMLDKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E161</accession>
    <name>B8E161_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583273.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352803.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0908"/>
    <dbReference type="EnsemblBacteria" id="ACK42189">
        <property type="protein sequence ID" value="ACK42189"/>
        <property type="gene ID" value="Dtur_0908"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0908"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.945"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_0"/>
    <dbReference type="InParanoid" id="B8E161"/>
    <dbReference type="OMA" id="AKNLQPW"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="168" mass="19449" checksum="DFFBF6272412B2E3" modified="2009-03-03" version="1">MDVFEAIKKRRSIRKYQNREIEEEKLLRILEAARLAPSARNRQEWRFIIVKDKKVKEELVKEASPHQPFMLQAPIIIVAYVIDKDYIMRCGVPAHYIDVAIALTHIHLQAVEEGLGTCWIGSFYQDKVKKVLNLPEEAEIIQLMTLGYPAEDPAPKTRLSLDEIVKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E168</accession>
    <name>B8E168_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583280.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352810.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0915"/>
    <dbReference type="EnsemblBacteria" id="ACK42196">
        <property type="protein sequence ID" value="ACK42196"/>
        <property type="gene ID" value="Dtur_0915"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0915"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097071_0_0_0"/>
    <dbReference type="InParanoid" id="B8E168"/>
    <dbReference type="OMA" id="DDMTPNN"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="249" mass="28705" checksum="E96A6C0ABDDFEE87" modified="2009-03-03" version="1">MTWIGVDLHIHTILSPCGDWNMSPKKIVEKAKEIGLGIIGITDHHMVENFPAVSYWGEKMDILVIPGMEIQTREEVHVLGLFKNYSSAYEFQKEIWNHLPDKKNDENLFGVQVVVNEKDEVERIEERLLLTSTNLSLEGVTKLIRKFDGFIILAHIDKPNFSVLSNLGFIPENLDYDLLELSKEVKIEKFLRDNYGLISKKNNFIISSDAHYLDDIKKPRTFIGVEGLTIEDVFFSLKNKIIKIEEMEV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-01-25" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E181</accession>
    <name>PNPH_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable 6-oxopurine nucleoside phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Purine nucleoside phosphorylase</fullName>
            <shortName evidence="1">PNP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_0928</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583293.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352823.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E181"/>
    <dbReference type="SMR" id="B8E181"/>
    <dbReference type="STRING" id="515635.Dtur_0928"/>
    <dbReference type="EnsemblBacteria" id="ACK42209">
        <property type="protein sequence ID" value="ACK42209"/>
        <property type="gene ID" value="Dtur_0928"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0928"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.965"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_0"/>
    <dbReference type="InParanoid" id="B8E181"/>
    <dbReference type="OMA" id="MTQCPEA"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000415081" description="Probable 6-oxopurine nucleoside phosphorylase">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <sequence length="263" mass="29405" checksum="64B2331F6F124FE0" modified="2009-03-03" version="1">MRIAIIGGTGVYDPKFLENPEEIKVSTPYGEVKLLKGIYQGEEVGFLARHGAGHTVPPHRINYKANMWALKSLGVERILSTTAVGSLKLNLVPGDLVILDQFIDFTKNRDHTFYNGDDGKVIHIDFTNPYCPELRNILYETSKEIGIKAHPFGTYVCTEGPRFETPAEIKMYSFFGDVVGMTNVPEVILARELEICYASVSLVTNYAAGISPNPLTHSEVLEVMTQNIEKVRKLFAAVIPKIPKERNCICKNALKEYREKGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1B8</accession>
    <name>B8E1B8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7 8">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="9" type="ordered locus">Dtur_0966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7 8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583330.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352860.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0966"/>
    <dbReference type="EnsemblBacteria" id="ACK42246">
        <property type="protein sequence ID" value="ACK42246"/>
        <property type="gene ID" value="Dtur_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0966"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1003"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1B8"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="232152at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    <keyword evidence="6 7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7 8" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0658">Purine biosynthesis</keyword>
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            <begin position="16"/>
            <end position="19"/>
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            <end position="44"/>
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            <begin position="302"/>
            <end position="308"/>
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    <feature type="active site" description="Proton acceptor" evidence="7">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="432" mass="48485" checksum="F1C912A2D88904D3" modified="2009-03-03" version="1">MTNEKTLVVIGAQWGDEGKGKIIDLLSQNAEVVVRFNGGNNAGHTVIVDGKTYRFRLLPSGIISPKTLNVIATGVIINLNGLLEEIEEAEKNGLLIKNLYISDRSPLVLPYHILLDKFYEEKRGNKKIGTTARGIGPAYTDHFSRDTLHVGDLFDKEVFKEKLNYIYSLKKATLSSDFQLPPFEEVYNSQLNTFEKLMEKGVTITDTSKLIYDHIKAGKKILFEGAQGTLLDINFGTYPFVTSSFTISGGVCVGAGIPPQSINKVIGVIKAYTSRVGEGPFPSEIKDELAEIIREKGQEYGTVTRRPRRVGWLDFVALRYAKRINGFTELAITKLDVLSGLEKLKFVVAYKYKGRIIDEFPSSLNILEKCEPITEEISGWKQSLKNIKNYNDLPENVIKYKERIEKELETKITIIGTGPARDEIILLKDPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1D3</accession>
    <name>B8E1D3_DICTD</name>
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        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
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        <name evidence="8" type="ordered locus">Dtur_0981</name>
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        <dbReference type="NCBI Taxonomy" id="515635"/>
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            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
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    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="Dtur_0981"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="215" mass="23897" checksum="9A0D93439A1D639C" modified="2009-03-03" version="1">MAAPTTKAILGRKIGMTQIFTENGEMVPVTVIRGGPCLVLNVRTKEKDGYDAIQLGFERCKESKLNKPQLGIFKKLGLPPFRIIKEVRVKNPLDYTKGQEIRVDIFQEGEFVDITGKSKGHGFTGHIKRWNFSRGRMSHGSKFHRRRASIGAGGVQHVMKGQKMAGRWGNETITVQNLKIVKVDKEKDLILVKGAVPGPTGNLLIIRKAVKKLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1D4</accession>
    <name>B8E1D4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ordered locus">Dtur_0982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0982"/>
    <dbReference type="EnsemblBacteria" id="ACK42262">
        <property type="protein sequence ID" value="ACK42262"/>
        <property type="gene ID" value="Dtur_0982"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0982"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1019"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_0"/>
    <dbReference type="InParanoid" id="B8E1D4"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="45"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="209" mass="23808" checksum="FBC520E4C1340E40" modified="2009-03-03" version="1">MIQVPVYNQKAEKVGEIELKEELFGVERRPDLFYTCVVMHLANGRQGTHSTKRRSEVNRSGRKVWPQKGTGHARQGDRKATHWVGGGRPFGPKPRDYSYKIPKKMRRLAIRSALSTKLKENNLIILDKIELPQPKTKELVNILNNFGLADSKVLIGVPTKDENLKKAAMNLERVKTMIASVLNVYDLLKYDYLILTVDAIPVLEEAFLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1F9</accession>
    <name>RS4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD</name>
        <name type="ordered locus">Dtur_1007</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583370.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352901.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1F9"/>
    <dbReference type="SMR" id="B8E1F9"/>
    <dbReference type="STRING" id="515635.Dtur_1007"/>
    <dbReference type="EnsemblBacteria" id="ACK42287">
        <property type="protein sequence ID" value="ACK42287"/>
        <property type="gene ID" value="Dtur_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1007"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1044"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_2_0"/>
    <dbReference type="InParanoid" id="B8E1F9"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045903">
        <property type="term" value="P:positive regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000140723" description="30S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="98"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <sequence length="206" mass="23982" checksum="BBECDD9A5A3F2209" modified="2009-03-03" version="1">MARYTGPDCRLCRREGMKLFLKGTKCFSEKCPFERRPFPPGQHGRAQRKLTEYGLRLREKQRAKRIYGVLERQFRRYFEIASKGRGVTGERLLQLLETRLDNVVYRLGWALSRAQARQIVSHGKIAVNGKRVNIPSYNLKPGDVVELLDKDLIPVQEAISVFGNKSVPAWLELDRENLRGKVLRLPKREEIDTPVQEQLIVEFYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1G9</accession>
    <name>B8E1G9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
            <ecNumber evidence="5">5.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582579.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352108.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0163"/>
    <dbReference type="EnsemblBacteria" id="ACK41494">
        <property type="protein sequence ID" value="ACK41494"/>
        <property type="gene ID" value="Dtur_0163"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0163"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="InParanoid" id="B8E1G9"/>
    <dbReference type="OMA" id="HDFHFVI"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="330" mass="36930" checksum="E4ACB89444E66F52" modified="2009-03-03" version="1">MITIKDVAREAGVSIATVSRVLNNSPKVREETKKRVLEAINRLGYSPSVVARSLATKTLKTNVISIFVPFFTRDFFVEVLRGINNVISKSDYSIHLYNVEKLEDKEKIFTREVFNRCDGMILVSFDIKKKEADFLKEMGKPVVLIDSFHPDFPSVYVDNKKGAYMAVKYLITTGRKNIAFVSGAIHDPLGFMASYKRYEGLLQALKEANLNFNPRLHIQTGFSWEKGYRAGKTLLSRGIPFDAVFCTSDIQAMGVMSAIVESGLRIPEDVAIIGFDDISDARYLGLSTVRQPMTEMGEVGAKILLDLLLGIDSSFTHIELPLELVIRLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1L8</accession>
    <name>B8E1L8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582628.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352157.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0214"/>
    <dbReference type="EnsemblBacteria" id="ACK41543">
        <property type="protein sequence ID" value="ACK41543"/>
        <property type="gene ID" value="Dtur_0214"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0214"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_3_0"/>
    <dbReference type="InParanoid" id="B8E1L8"/>
    <dbReference type="OMA" id="DWMMMCE"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:microcin transport"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
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        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="78"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="609" mass="69579" checksum="C7204FE6BE5EF8C7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Q0</accession>
    <name>B8E1Q0_DICTD</name>
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        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582660.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352189.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0249"/>
    <dbReference type="EnsemblBacteria" id="ACK41575">
        <property type="protein sequence ID" value="ACK41575"/>
        <property type="gene ID" value="Dtur_0249"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0249"/>
    <dbReference type="eggNOG" id="COG1120">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="InParanoid" id="B8E1Q0"/>
    <dbReference type="OMA" id="KALCQEI"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
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    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="252" mass="28674" checksum="9CCD6E9D90BC750E" modified="2009-03-03" version="1">MILEIQGLHFSYRSTPVLKNVTFSVREGEMVGILGNNGAGKSTLIKCINKILSPKEGVIYLNKKDIRNIKRREVAKLIGYVAQKYDYYNLTVFDVILLGRRPHIKWDATLKDLEIVERIIRDLNLQHIALRSVDEISGGELQKVIIGRALAQEPKILLLDEPTNNLDLKNQIEVLQFIKEYVINKNISALVVLHDVNLALRFCDKFIFLKNNTIYAQGTIEMINEKIIEEVYGVKVVIDKVNNIPVVVPLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1R2</accession>
    <name>B8E1R2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit</fullName>
        </submittedName>
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    <gene>
        <name evidence="6" type="ordered locus">Dtur_0261</name>
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    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582672.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352201.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0261"/>
    <dbReference type="EnsemblBacteria" id="ACK41587">
        <property type="protein sequence ID" value="ACK41587"/>
        <property type="gene ID" value="Dtur_0261"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0261"/>
    <dbReference type="eggNOG" id="COG1144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_1_1_0"/>
    <dbReference type="InParanoid" id="B8E1R2"/>
    <dbReference type="OMA" id="GSWRTFK"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011898">
        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
        <property type="entry name" value="PTHR43724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="92" mass="10576" checksum="671507D49CC3F3EF" modified="2009-03-03" version="1">MKLPGWKELVNIGPILPAQTSKEYKTGDWRTFRPEIDYNKCTTCMFCWLFCPDSAVKFDGQKVYIDYDYCKGCGVCAAECPVKAITMKEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1T8</accession>
    <name>B8E1T8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide-transporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582806.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352335.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0417"/>
    <dbReference type="EnsemblBacteria" id="ACK41721">
        <property type="protein sequence ID" value="ACK41721"/>
        <property type="gene ID" value="Dtur_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0417"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.440"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1T8"/>
    <dbReference type="OMA" id="LSLHREW"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="318" mass="34504" checksum="613C2E13CF200022" modified="2009-03-03" version="1">MKIRLRITWEIILLILIVLVFLVSSFFSPYFLDIVNLLDNTTNFMEKGLISLAMTYIIISGNIDISVASNMGMTSAFMGVLHRMGTNIWICALVGLIIATLGGYLNGYLIVRFRLPAIAVTLGTYALYRGIAYILLQDTAVGIESESFMYLGQGYIAGTPVPFSLVLYVIFAIIFGFVLHKTTFGRYVYSIGNNEQACKFSGIPVEKIKIVLFTIAGFMSGLGAILLTSRLSSIRPDIGSGLELEVIATVVLGGVSILGGSGNMIGVVLSLFLIGFLTYSLNLLNIPSQVITIIMGSLLVGTVVISNLLEQRRARAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1V0</accession>
    <name>B8E1V0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pectate lyase/Amb allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352347.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0431"/>
    <dbReference type="CAZy" id="PL1">
        <property type="family name" value="Polysaccharide Lyase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41733">
        <property type="protein sequence ID" value="ACK41733"/>
        <property type="gene ID" value="Dtur_0431"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0431"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.455"/>
    <dbReference type="eggNOG" id="COG3866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516525_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1V0"/>
    <dbReference type="OrthoDB" id="660314at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PTHR31683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870584" evidence="3">
        <location>
            <begin position="26"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="4">
        <location>
            <begin position="129"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="527" mass="59210" checksum="FAF6BEACB4CA314B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Z4</accession>
    <name>B8E1Z4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582862.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352391.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0477"/>
    <dbReference type="EnsemblBacteria" id="ACK41777">
        <property type="protein sequence ID" value="ACK41777"/>
        <property type="gene ID" value="Dtur_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0477"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.503"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="InParanoid" id="B8E1Z4"/>
    <dbReference type="OMA" id="AFMYMGD"/>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="252" mass="28750" checksum="02BE8D471C111052" modified="2009-03-03" version="1">MDKIRVENLNAWFGNMRVLKDISLSIKERQITAIIGPSGCGKTTLLRCFNRLHELSPGARVEGKIFLDDLNIYNKNVDPVMVRRRIGMVFQRPNLFNHMNLYDNVIAGYILNNKKLPKEELDKIVEESLKLAGIWDEVKNRLKDYPSALSGGQQQRVCIARALAVKPEVLLMDEPTSALDPISTYRIEETIKELKEHITIIIVTHNMQQAARVSDYTAFMYMGELIEVGPTPQIFTNPKQKLTEDYITGKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E231</accession>
    <name>B8E231_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583391.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352922.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1028"/>
    <dbReference type="EnsemblBacteria" id="ACK42308">
        <property type="protein sequence ID" value="ACK42308"/>
        <property type="gene ID" value="Dtur_1028"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1028"/>
    <dbReference type="HOGENOM" id="CLU_1945325_0_0_0"/>
    <dbReference type="OMA" id="KIVNYGN"/>
    <dbReference type="OrthoDB" id="2136018at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="129" mass="14797" checksum="C3824FA7B93F9198" modified="2009-03-03" version="1">MKCQKVGTERGFSLLEALVVGVLLLISIIGILQMYSVTFYNAPKVDNLMMANYILTKEVEIVLAQTYTTLDNFLSSNYPKIVNYGNVNYTITYTLLDNINWGKYIRIINSWREGKENKNLSIELFKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E253</accession>
    <name>B8E253_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">33 kDa chaperonin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Heat shock protein 33 homolog</fullName>
            <shortName evidence="6">HSP33</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hslO</name>
        <name evidence="7" type="ordered locus">Dtur_1050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HSP33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583413.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352944.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1050"/>
    <dbReference type="EnsemblBacteria" id="ACK42330">
        <property type="protein sequence ID" value="ACK42330"/>
        <property type="gene ID" value="Dtur_1050"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1050"/>
    <dbReference type="eggNOG" id="COG1281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054493_1_0_0"/>
    <dbReference type="InParanoid" id="B8E253"/>
    <dbReference type="OMA" id="DMQCECC"/>
    <dbReference type="OrthoDB" id="1406579at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00498">
        <property type="entry name" value="Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00117">
        <property type="entry name" value="HslO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0862">Zinc</keyword>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="237"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="6">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="295" mass="32842" checksum="405B3450F8401E50" modified="2009-03-03" version="1">MDYLIRGISMDKRIVAYVARTTDLVEQARKIHKASPTAIAALGRTLTLAAIMGKMLKKDEERISLQITGNGPLGNIFAEADPKGNVRGFIKRAYIDLPPTPDGKLDVPSAVGKDGTLSVIRDLGLKEPYRGVVPLISGGIAKDLAYYFTYSEQLPSAVAAGVYVNKDGRVISAGGYIVQIIENADNDMVDILESNIKNLDPPSKMILEGKTPEEIMSKIFKDIDYEQFSREYLKYSCRCNRERAENTLIALGIKELEELIEKEKSIEVKCEFCGKIYIFNKNNIEEIINQLKNKT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E259</accession>
    <name>AROB_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate synthase</fullName>
            <shortName evidence="1">DHQS</shortName>
            <ecNumber evidence="1">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroB</name>
        <name type="ordered locus">Dtur_1056</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583419.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352950.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E259"/>
    <dbReference type="SMR" id="B8E259"/>
    <dbReference type="STRING" id="515635.Dtur_1056"/>
    <dbReference type="EnsemblBacteria" id="ACK42336">
        <property type="protein sequence ID" value="ACK42336"/>
        <property type="gene ID" value="Dtur_1056"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1056"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1093"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_2_0"/>
    <dbReference type="InParanoid" id="B8E259"/>
    <dbReference type="OMA" id="YGVIWDA"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000117483" description="3-dehydroquinate synthase">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <sequence length="355" mass="40988" checksum="CB9D49E6C0403ABC" modified="2009-03-03" version="1">MEELTIDLKDKKYPIYIGYNILRRLIKEYWDKYSSSFLITHPFLREIYKEDLSIPEENVIYVPVGEKSKSFQEVIKISKELAKRMADRRSALFAFGGGVVGDLTGFIASIYMRGIKYIQIPTTLLSQVDSSIGGKTGINIREGKNLIGTFYHPDAVIIDIKTLDTLSEREYKSGIAEVIKYGMIMNYEFFKFLEKNVDSILSKDVDKLLYVIKESLLCKKYVVEKDEKESSLRMILNFGHTFGHAIEAKGGYRRFLHGEAVAIGMLLATYLGYKLGFCNYEVLERLKELLMLFGFKIKSPYRIEDLMEYIKRDKKAYGGKLRLILPREIGRVEIVEDIEEKDIIKILKEGDDYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E265</accession>
    <name>B8E265_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1062</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583425.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352956.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1062"/>
    <dbReference type="EnsemblBacteria" id="ACK42342">
        <property type="protein sequence ID" value="ACK42342"/>
        <property type="gene ID" value="Dtur_1062"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1062"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8E265"/>
    <dbReference type="OMA" id="GRMPRWR"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="322" mass="36114" checksum="04641A5E970B909C" modified="2009-03-03" version="1">MANTVLKLNNFTVVYKTQQGPLEAVRNVSFELKEGETLAIVGESGCGKSSLARGILRLFPRNLEKASGEIYINETEVLSLKEEDFRKNIRWSKISMVFQGAMNSLNPILKIVHQVAEPLIVHFGMEKTSAYKRAKEILNLVGISESFAERYPFELSGGMKQRVVIAMALVTRPNIVILDEPTSALDVITQANIMNLLKVLKKELNLSYIFITHDIATASELADRVAVMYAGEIVEISPSEKFYNSPAHGYTMMLLNSVPTLKTTKKLKSIPGSPPSLINPPSGCRFHPRCQYVMDICREKEPPMFKKDEEHYAKCYIGESHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E290</accession>
    <name>B8E290_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="5 8">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">clpP</name>
        <name evidence="11" type="ordered locus">Dtur_1088</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 9">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 10">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="5 8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583450.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352981.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1088"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="ACK42367">
        <property type="protein sequence ID" value="ACK42367"/>
        <property type="gene ID" value="Dtur_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1088"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1124"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_0"/>
    <dbReference type="InParanoid" id="B8E290"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 8" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="194" mass="21599" checksum="A10D2E5CDCE95A37" modified="2009-03-03" version="1">MLVPIVIEQTPRGERAYDIYSRLLKSRIVFLGTTINDEVANLIVAQLLFLESEDPEKDIYLYINSPGGEVSAGLAIYDTIRHIKPKVATVCVGQAASMAAILLAAGDKGKRYALPHSRVMIHQPLGGAYGPAADIEIHTREILKIKRVLNEILAYHTGQPIEKIEKDTDRDFFMSAYEAKEYGIVDEVLESKKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E291</accession>
    <name>CLPX_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpX</name>
        <name type="ordered locus">Dtur_1089</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583451.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352982.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E291"/>
    <dbReference type="SMR" id="B8E291"/>
    <dbReference type="STRING" id="515635.Dtur_1089"/>
    <dbReference type="EnsemblBacteria" id="ACK42368">
        <property type="protein sequence ID" value="ACK42368"/>
        <property type="gene ID" value="Dtur_1089"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1089"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1125"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_0"/>
    <dbReference type="InParanoid" id="B8E291"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009376">
        <property type="term" value="C:HslUV protease complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000189688" description="ATP-dependent Clp protease ATP-binding subunit ClpX">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="ClpX-type ZB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <sequence length="411" mass="46144" checksum="162E52A141A888DF" modified="2009-03-03" version="1">MSDKNIRCSFCGRTQKEVKKLIAGPGVYICDECVKLAYDIIEEEDSEEIEEENQEFVLPKPHEIKNFLDQYVIGQERAKKILSVAVYNHYKRIFMRSKITEDVEIQKSNVLLIGPTGVGKTLLAETLAKFLKVPFAIADATTLTEAGYVGEDVENILLRLIQNADWDIKRAEKGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLRIVEGTIANVPPQGGRKHPYQEFIQINTKDILFIAGGSFEGIEKIVEKRLDVSNIGFGAQIEPKNRKSLTQILNHIIPEDLIKFGMIPEFVGRFPVVAVLEPLSEEALLKILTEPKNALVKQYKALLSMEGVEINFTDEALKAIVKEAIDKATGARGLRAVMEELMLDLMYELPNLGIKKFTVTPELVYNRNKISQDLLKKLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2A3</accession>
    <name>B8E2A3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352994.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1101"/>
    <dbReference type="MEROPS" id="M23.009"/>
    <dbReference type="EnsemblBacteria" id="ACK42380">
        <property type="protein sequence ID" value="ACK42380"/>
        <property type="gene ID" value="Dtur_1101"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1101"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_4_3_0"/>
    <dbReference type="InParanoid" id="B8E2A3"/>
    <dbReference type="OMA" id="SDPAQWC"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="276"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="375" mass="42529" checksum="B77DB3D29D365761" modified="2009-03-03" version="1">MRRFVIIILILSLMLVSIYGADTSSIILQKQKELQQKQKQIQSLKQQIKNLESVEVNIVREITKIDQDLDRAERELNVAESRLREAQAKLTVLSTQLSILQRNLKYRSLNFKENLGDSYKLLQINNSFSLIFLNDAFFQIAVPYYLKTLMKLEAGRLNNLNTQCKDIQQTKKRWEEEEKRVEALVKSIAEKKAYIEKKKKEKLAYLEKVRTQKRYQQQVVATLERESKEIEQMIRRLASSNIQKAQKGKLSWPVIGGITSGFGMRRHPLLGGAPLFHTGIDISASYGTPIRAAASGRVIFAGWYGGYGNMIIIDHGGKISTVYGHLSKIVVKVGEEIAEGDVIGYVGSTGLSTGPHLHFEVRINGDPVDPLTWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2A9</accession>
    <name>B8E2A9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 4</fullName>
            <shortName evidence="5">EF-4</shortName>
            <ecNumber evidence="5">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lepA</name>
        <name evidence="7" type="ordered locus">Dtur_1107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583469.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353000.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1107"/>
    <dbReference type="EnsemblBacteria" id="ACK42386">
        <property type="protein sequence ID" value="ACK42386"/>
        <property type="gene ID" value="Dtur_1107"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1107"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1143"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_0"/>
    <dbReference type="InParanoid" id="B8E2A9"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="17"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="600" mass="67979" checksum="4F7C682ABE66544A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2B0</accession>
    <name>B8E2B0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="5">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">surE</name>
        <name evidence="7" type="ordered locus">Dtur_1108</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="5">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583470.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353001.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1108"/>
    <dbReference type="EnsemblBacteria" id="ACK42387">
        <property type="protein sequence ID" value="ACK42387"/>
        <property type="gene ID" value="Dtur_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1108"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1144"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_3_0"/>
    <dbReference type="InParanoid" id="B8E2B0"/>
    <dbReference type="OMA" id="DCVHIAL"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008254">
        <property type="term" value="F:3'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046050">
        <property type="term" value="P:UMP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SurE" evidence="6">
        <location>
            <begin position="6"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="252" mass="28320" checksum="FD6F2A9390254EE7" modified="2009-03-03" version="1">MRKYRILITNDDGINSPALKIMGNKLSIFGEIYIIVPERERSGGSHAITLHKPLRINEINWSLEKVKVWSTNGNPADCVLLGLYAILAQKPDLVISGINRGYNLGNDIIYSGTVSGAREASLNGIPAIAISVYQDGKEEDFEKATDLLISLFDKFLKIIPEGTFLNINIPPNAKITDICLTYQGKFHYRNIVEKRLDPRNKEYFWLHGYVEENGEEGSDIWAIKNGKISITPLQSDMTNYSLLNALKSYDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2B6</accession>
    <name>B8E2B6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, FmdB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583476.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353007.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1114"/>
    <dbReference type="EnsemblBacteria" id="ACK42393">
        <property type="protein sequence ID" value="ACK42393"/>
        <property type="gene ID" value="Dtur_1114"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1114"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_3_2_0"/>
    <dbReference type="InParanoid" id="B8E2B6"/>
    <dbReference type="OMA" id="TYQYQCT"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="74" mass="8424" checksum="3F856900F9CA4443" modified="2009-03-03" version="1">MPIYEFECENCHERYEIMTNIGEELPKTCVKCGGNLRKVFSPVGIVFKGSGFYTTDYKRKNSESKSSSESEGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2J5</accession>
    <name>B8E2J5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583914.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353453.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1565"/>
    <dbReference type="EnsemblBacteria" id="ACK42839">
        <property type="protein sequence ID" value="ACK42839"/>
        <property type="gene ID" value="Dtur_1565"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1565"/>
    <dbReference type="eggNOG" id="COG1668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050524_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2J5"/>
    <dbReference type="OMA" id="IMMLIIM"/>
    <dbReference type="OrthoDB" id="1251879at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="433" mass="48274" checksum="0B2E05BB867F0441" modified="2009-03-03" version="1">MKKFTNLLKKEIRELVTLQLIISLIFTIILFNFLGSLTKSEIKKSVQLRDVYVLDLDKTDFSKELLNNLSVGGFRVNLINKEIQREDKNLAIDYARMKNLNFLLIIPRGFGDKVSSFQSTEVEFYSFIKSFSMGSTVGSSIVNNIINSINNYVSNNFLKAKFPNLNPESIKNPIKSKEFVIIKDRIAEASSSEVMNFVYSQSVFIPIVLMLVITYASQMVLSAIALEKQDKTLETLLTVPVSRRYIVVAKMAGAGIVGLISAGVYMLGYRSFFSGITGGVDINKLSSDIITKLGISFTPYGYLLLGLSLFLAILNALALSTILGVLSEDLRSAQGFSFPIIILIMIPYFLSLFTDINSLSLPVKLLVYAIPFSHPFIASSNILLGNYNIVYYGILYMLIVFIILIFIAARIFSTDQVITMKLRFGKKAKIGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2R0</accession>
    <name>B8E2R0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="2">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Alpha-IPM isomerase</fullName>
            <shortName evidence="2">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">leuD</name>
        <name evidence="4" type="ordered locus">Dtur_1631</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583979.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353518.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1631"/>
    <dbReference type="EnsemblBacteria" id="ACK42904">
        <property type="protein sequence ID" value="ACK42904"/>
        <property type="gene ID" value="Dtur_1631"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1631"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081378_1_1_0"/>
    <dbReference type="OMA" id="DDVNTDY"/>
    <dbReference type="OrthoDB" id="1384217at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="3">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="166" mass="18608" checksum="13495FE96A3971A7" modified="2009-03-03" version="1">MLIRGKAHKFGDDINTDYIISGKYKFKSLDFNEMSKHLFEDLDPDFYKKITPGDIIVAGKNFGCGSSREQAPLVIKHAGISLVIAKSFARIFYRNSINVGLPLLEADTNQIDQGDELEVDLFNGKIFNKTKNVVINSKSTFPDIMVKILQAGGLVEYLKKEGDFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2R8</accession>
    <name>B8E2R8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dak phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583500.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353032.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1139"/>
    <dbReference type="EnsemblBacteria" id="ACK42418">
        <property type="protein sequence ID" value="ACK42418"/>
        <property type="gene ID" value="Dtur_1139"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1139"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1176"/>
    <dbReference type="eggNOG" id="COG1461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017496_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2R8"/>
    <dbReference type="OMA" id="TRTIPQG"/>
    <dbReference type="OrthoDB" id="1554133at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019986">
        <property type="entry name" value="DAK2_dom-cont_prot_YloV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033470">
        <property type="entry name" value="UPF_DhaK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13684">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01121">
        <property type="entry name" value="Dak1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="SSF101473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03599">
        <property type="entry name" value="YloV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DhaL" evidence="1">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="544" mass="61684" checksum="18CE142187AB3189" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2U0</accession>
    <name>B8E2U0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="15" type="ordered locus">Dtur_1161</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353054.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1161"/>
    <dbReference type="EnsemblBacteria" id="ACK42440">
        <property type="protein sequence ID" value="ACK42440"/>
        <property type="gene ID" value="Dtur_1161"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1161"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1198"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_0_2_0"/>
    <dbReference type="InParanoid" id="B8E2U0"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="1419877at2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047952">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="13">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="14">
        <location>
            <begin position="184"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACK42440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="346" mass="38177" checksum="F2D8F4F14913FBB8" modified="2009-03-03" version="1">MEGKKIKIAVFGSGSWGTALANVLCEKNYKVVLWGRDKEKVKKIEELRENIYYLPGYKLAPSLEITSNIDYATKDTDIAILSIPIQGLREFLKGNNTYLKRAGFFVNTGKGIEILTLKRPSEIIKEELDVDFNQIATLSGPSFAKEVMEKKPLAIVIASSDLNTAKYLQDILSLSFMRIYRSDDIVGVEIGGALKNVIAIAAGISDGLGFGYNAKASLITRGLVEINRMAILYGAHPFTILGLSGLGDLILTSTSALSRNWTVGKLIGEGLSLEEAMNKLNGMVAEGVYTAKSAYYISQKTNVYMPITQEVYKVLYENKPPHEALSSLLSKELKHEIDEDFQFNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2U2</accession>
    <name>B8E2U2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583524.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353056.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1163"/>
    <dbReference type="EnsemblBacteria" id="ACK42442">
        <property type="protein sequence ID" value="ACK42442"/>
        <property type="gene ID" value="Dtur_1163"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1163"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1200"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8E2U2"/>
    <dbReference type="OMA" id="YEPAHPY"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="37163" checksum="14C3AA966A7CC076" modified="2009-03-03" version="1">MNDLLLEVKNLKTYFFTDEGIVKAVDDVSFNLHKGESLGIVGESGSGKSVTALSIMRLIQDPPGKIVSGEVWYRGEDLLKKKESDMREIRGNKISMIFQDPMTSLNPVFTIGDQIMEAIILHQKLDKASARKKAIEMLELVRIPEANKRVDEYPHQFSGGMRQRVMIAMALSCNPEILIADEPTTALDVTIQAQILDLIKQLQRELGMSLILITHDMGVVAETCHNVLVMYAGKVVEYADVKTIFKKPAHPYTIGLLESVPRLDIRKERLKAIEGQPPDLISLPNYCYYAERCPYRTSECFEQIPELVEVEPGHYSRCIYAKNLGRSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2U7</accession>
    <name>B8E2U7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II secretion system protein E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1168</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583529.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353061.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1168"/>
    <dbReference type="EnsemblBacteria" id="ACK42447">
        <property type="protein sequence ID" value="ACK42447"/>
        <property type="gene ID" value="Dtur_1168"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1168"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1205"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_6_0"/>
    <dbReference type="InParanoid" id="B8E2U7"/>
    <dbReference type="OMA" id="RSRIDGM"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSE_N" evidence="3">
        <location>
            <begin position="40"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="182"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="561" mass="63163" checksum="83E40D40936E2E00" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2V2</accession>
    <name>B8E2V2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583534.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353066.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1173"/>
    <dbReference type="EnsemblBacteria" id="ACK42452">
        <property type="protein sequence ID" value="ACK42452"/>
        <property type="gene ID" value="Dtur_1173"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1173"/>
    <dbReference type="HOGENOM" id="CLU_1956098_0_0_0"/>
    <dbReference type="OMA" id="VWKEENN"/>
    <dbReference type="OrthoDB" id="2137609at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="128" mass="14997" checksum="DEBC7BBAA867B194" modified="2009-03-03" version="1">MRKGLTFLEVLIAVLLLGIIMSSVGVAISYILRADEYENMMNICLYLTEKKLEEYRKAVLANWNISFTYSGNFANIGYTDFFYSLTVFNTTYSLKQIFLQVWKEENNNNKLDDFEPETIIITYISRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2V7</accession>
    <name>B8E2V7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583539.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353071.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1178"/>
    <dbReference type="EnsemblBacteria" id="ACK42457">
        <property type="protein sequence ID" value="ACK42457"/>
        <property type="gene ID" value="Dtur_1178"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1178"/>
    <dbReference type="HOGENOM" id="CLU_1501224_0_0_0"/>
    <dbReference type="OMA" id="TYFVINM"/>
    <dbReference type="OrthoDB" id="2122232at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="179" mass="20593" checksum="E7076C2400114EFD" modified="2009-03-03" version="1">MKKIDYLLSTFLIASLGLNTYLVVNVDRLLREDFEEIVLAKKISFVKQDAEKIEDIKAIKTMDGIRKNYRLSLGRDDPFKPLIKVEKEKISIKNSVSIDKTVPKVVSELEKPPFILRGILKGEYSEVAILERVGREESFVVEKGKEIDGYHIIKLDINNNTITLRKNNKDYILKLVGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2X5</accession>
    <name>B8E2X5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Dtur_1196</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583557.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353089.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1196"/>
    <dbReference type="EnsemblBacteria" id="ACK42475">
        <property type="protein sequence ID" value="ACK42475"/>
        <property type="gene ID" value="Dtur_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1196"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1233"/>
    <dbReference type="eggNOG" id="COG1085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2X5"/>
    <dbReference type="OMA" id="HAIYYPP"/>
    <dbReference type="OrthoDB" id="1064872at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="172"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACK42475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="324" mass="38176" checksum="B0FC90CBD4BC75D1" modified="2009-03-03" version="1">MSSELRWHPFLKEWVIVAGKVQERPVLPARNACPLCYGGIEVPKPFDIAVFENRYPSLTKETPDITEWEDEIYKVKGGKGVCEVVLYTMDHDSSMSRMPLEQIEKLILVWEDRYKDLGSLDFIQYVLIFENRGEIVGVSLHHPHGQIYAFPFIPPIIEKELKATNEFYEEYKKCLFCSILEKELKEEKRIVYENKYFTAFMPFYGKYPFELHIYSKRHLGSLTEMTYAEKMYLAEIIQKITKAYDNVYGFNFSYMMVFHQKPVKGDYPNYHFHVEFYSLHRAKDKIKYLASVESGAGTFINPLPPEESAELMRESLRRISKNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Z5</accession>
    <name>B8E2Z5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583577.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353109.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1216"/>
    <dbReference type="EnsemblBacteria" id="ACK42495">
        <property type="protein sequence ID" value="ACK42495"/>
        <property type="gene ID" value="Dtur_1216"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1216"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1254"/>
    <dbReference type="HOGENOM" id="CLU_1136638_0_0_0"/>
    <dbReference type="OMA" id="IVKTFGI"/>
    <dbReference type="OrthoDB" id="1452951at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021737">
        <property type="entry name" value="Phage_phiKZ_Orf197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11750">
        <property type="entry name" value="DUF3307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="244" mass="28926" checksum="02EA983D3552E1FC" modified="2009-03-03" version="1">MFWFLRLFLAHLIADFPLQTNKIFEFKRSTPYGILAHTGIYFLISVILSIPYLRYLDAVIFLIFLFSIHTLIDVSKVRNFLSKDGLKEFLLDQFKHFLSLMLVFLLPSGNRVLYLSLPESLRFIERFYNSDYYILLGIGYFFVSFAGTIFYFYIVKTFGIKNFFGKEGISTKSKYLEVLFRSVIFFVYYKFSFFYSLIVFLMLRILEILANKNYKGVGSIFLIVLYDFVFIFSMIYFLNNLLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E327</accession>
    <name>B8E327_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13 14">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="5 13 14">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">murD</name>
        <name evidence="17" type="ordered locus">Dtur_1249</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="5 13 14"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583609.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353141.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1249"/>
    <dbReference type="EnsemblBacteria" id="ACK42527">
        <property type="protein sequence ID" value="ACK42527"/>
        <property type="gene ID" value="Dtur_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1249"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1289"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_0_0"/>
    <dbReference type="InParanoid" id="B8E327"/>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="OrthoDB" id="1093223at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8 13 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 13 14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="12 13 14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13 14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="115"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="316"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACK42527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="456" mass="52142" checksum="2E5362F22FDF378B" modified="2009-03-03" version="1">MEFDLKGKRVLVLGLGESGISTTKFLKEEGAKVIVNDYKEEEDFKNLLDFFRNNDILYIFGGHPIEILRNIDLVVISPGIPKTNPIYIEAKKRDIKVISEIELAYWYAKVPIIAITGTKGKSTTTTLIGEILKNAGIPNIVAGNIGLPFISVVKDLKEGYFVLEVSSFQLEDIEKFRPFISLFINIYPDHLDRYSSMDEYMLAKSRIFMNQKEEDYAILSYDQEEIINLAKPYKVKKLFFGFKKHENDGIFYDESRNKVFYKLSERYGSLTIPKGIWNRILISNFMASALVGLLLGVEERVIEKTGEDFQGIPFALQRIGELNGRVFVNDSKATNPVSTSSAINSINSPIILILGGRNKNFDFHELFENIKKSKVRRVVLIGETKEIMRELSEEYEIPYVIADSLEDAVRRAYEVSEPGDVILLSPACASFDMFRNYKERGKIFNDVFERMKNEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E362</accession>
    <name>B8E362_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584011.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353550.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1664"/>
    <dbReference type="EnsemblBacteria" id="ACK42936">
        <property type="protein sequence ID" value="ACK42936"/>
        <property type="gene ID" value="Dtur_1664"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1664"/>
    <dbReference type="eggNOG" id="COG1409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101517_0_0_0"/>
    <dbReference type="InParanoid" id="B8E362"/>
    <dbReference type="OMA" id="MVFAGHI"/>
    <dbReference type="OrthoDB" id="1242748at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="38"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="252" mass="29270" checksum="95179C6E1D391C79" modified="2009-03-03" version="1">MRNTSKILAIIFLFISLYSTIYAFTFAVIGDRAGRPVFGVFERNLSEVVKRKPDFIVQLGDILVESSDEEYRYVGSILKNVSVPFYIVPGNHDLYKDPKGARFQSFTKRPLYYYFDYENARFIILNNASGSLGKVQLEWLIEVLKGTNKKYKFVFMHQPVISPSWFFLFHKADPVESKILMKLFEEYHVNYVFSGHIHMYYRKEINGVVYIISGIGGARPYISSNLDEGKPHFILIKVSDEGINEEVVRLNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E368</accession>
    <name>B8E368_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alpha-galactosidase</fullName>
            <ecNumber evidence="2 5">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2 5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584017.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353556.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1670"/>
    <dbReference type="CAZy" id="GH36">
        <property type="family name" value="Glycoside Hydrolase Family 36"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42942">
        <property type="protein sequence ID" value="ACK42942"/>
        <property type="gene ID" value="Dtur_1670"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1670"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1720"/>
    <dbReference type="eggNOG" id="COG3345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009640_2_1_0"/>
    <dbReference type="InParanoid" id="B8E368"/>
    <dbReference type="OMA" id="WEGIYFD"/>
    <dbReference type="OrthoDB" id="131906at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052692">
        <property type="term" value="F:raffinose alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14791">
        <property type="entry name" value="GH36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038417">
        <property type="entry name" value="Alpga-gal_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GLHYDRLASE36"/>
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        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5 10" id="KW-0378">Hydrolase</keyword>
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        <location>
            <begin position="30"/>
            <end position="283"/>
        </location>
    </feature>
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        <location>
            <begin position="647"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="364"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="474"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="476"/>
        </location>
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    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="546"/>
        </location>
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        <location>
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        <ligand>
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        <ligand>
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            <position position="546"/>
        </location>
        <ligand>
            <name>substrate</name>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005536-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="726" mass="84536" checksum="3666A8564FC75101" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E390</accession>
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        <submittedName>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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            <dbReference type="PubMed" id="28066333"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 6724 / Z-1310</strain>
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    </reference>
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    <dbReference type="HOGENOM" id="CLU_019796_1_0_0"/>
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    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    </dbReference>
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            <end position="304"/>
        </location>
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            <end position="273"/>
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        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACK42964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
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    </evidence>
    <sequence length="310" mass="35578" checksum="272E2C5022B52E52" modified="2009-03-03" version="1">MKVYIAYPLKEEYLERIKEARNDVEIVENIEEAEVFLGGHISKDDLKKAKNLKWIQSSSAGIDNLLFEELLNSDIIITTASGVHPKPIAEHVFALLLSWTRRINIALRGKFERKWNRDEIKWCEELTGKTMGIIGYGKIGQEIGRIAKSFGMKVIGVKRDINQKDDMVFLPDELFSYKDLHEVLRRSDIIVLVLPLTSETKDLIGEEEFKVMKKDAIFINVGRGKTVKEDALVKALENGQIQCALLDVFYEEPLPEESPLWNLENVIITPHIAGMTPYYDDRLVEIFIHNLKNYPEVSRMLNVVDKSLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
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            <dbReference type="PubMed" id="28066333"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
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    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42979.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
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            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="101"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="327" mass="37233" checksum="F05DD11F2FD655E9" modified="2009-03-03" version="1">MKEYLLRRILYMLLTLFFVSIIVFVVIQLPPGDFLTSYIAQLATSGESVNLETIEALKKQYGLDKPIWEQYLLWIWNVLHGDFGRSLLYNRPVSELIGERLAITFVISLFTLVFIWVVGFLIGTYSATHQYSFGDYFFTFLGYIGLSVPAFMVALILLWVAYAYFGQNLTGLFSPEYLEAKWSFAKFVDMLKHIWVPVVIIGLANTAGMIRTLRANLLDELNKPYVLTARAKGLKEWKVVFKYPLRVAMIPFISTVGWSLPFLVSGAEITAIVLNLPTSGPLLLEALRNQDMYLAGAFLLMLSFLTMLGTLISDLLLAWVDPRVRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3B9</accession>
    <name>B8E3B9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584068.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353607.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1721"/>
    <dbReference type="EnsemblBacteria" id="ACK42993">
        <property type="protein sequence ID" value="ACK42993"/>
        <property type="gene ID" value="Dtur_1721"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1721"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_0"/>
    <dbReference type="InParanoid" id="B8E3B9"/>
    <dbReference type="OMA" id="GKAYMFF"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="286" mass="32390" checksum="2521DD91AA882D0B" modified="2009-03-03" version="1">MGVLRDLLRDGKFRLGFIIICIILFLAILSFFSPYDPTRWNLVPRDLPPSLQHILGTNSQGQDVFWQLTFAVRNSLTIAIVAAFFSRIIAIIVGLVAGYRGGGIDRFLMGINDSFLVLPLLPILILISSLIKGRLSFIGLGLILSFFGWSWDARVIRSQILSLRERDFSYTALLSGSKTLSLVFKEYFPFVIPIVFSTLINNMSWAIGMEMTLAILGLTNLEIPTLGTMLQWALSYQALLLGLWWWLFTPVVTSVFLFVSLYLLSVSISEYLDPRTRIQRIRVIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3D7</accession>
    <name>B8E3D7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-N-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584086.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353625.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1739"/>
    <dbReference type="CAZy" id="GH51">
        <property type="family name" value="Glycoside Hydrolase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK43011">
        <property type="protein sequence ID" value="ACK43011"/>
        <property type="gene ID" value="Dtur_1739"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1739"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1791"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010060_2_0_0"/>
    <dbReference type="InParanoid" id="B8E3D7"/>
    <dbReference type="OMA" id="MFEEMDH"/>
    <dbReference type="OrthoDB" id="620389at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010496">
        <property type="entry name" value="3-keto-disaccharide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06439">
        <property type="entry name" value="DUF1080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="456"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="824" mass="94705" checksum="12E2B7972410DC3A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3E1</accession>
    <name>B8E3E1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584090.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353629.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1743"/>
    <dbReference type="EnsemblBacteria" id="ACK43015">
        <property type="protein sequence ID" value="ACK43015"/>
        <property type="gene ID" value="Dtur_1743"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1743"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1795"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_3_0"/>
    <dbReference type="InParanoid" id="B8E3E1"/>
    <dbReference type="OMA" id="NLDWPGW"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK43015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="447" mass="50853" checksum="D7585F692C815E90" modified="2009-03-03" version="1">MRKFLVLATVSLFLLLIVGGYAQKQVVLNVWSSPDNADALQDIAQRFMQKYPNIKVQVTPISWEVLYPRMLADVASGTGAFDVATWDVMTAGAVAKGFVDLEEFRKQNPDLVDPNWDMKDFDPTIWHIAGIWAGKNIGIPFYCNTMLFYYRKDLFSDSKLKAEFKKMFGKDLRVPRTWEETVEVAKFFTKKYNPNSPTEYGIALMFPRTHTLFYMYLLYFAPYRRSQEGLKKWGPVDLDYGDYFTSDKKPAFNSPEGVKALETMKALMPYSPDPLGSDYGETLEYFARGTVAMVPQWTGVWATFKTSSALQPIDKKVGVAVMPGGHSVSGNWALGLNVASKNKREAFMFIQFATNKENDKIKFIKYGVAPSRLSTVRDPEVRKADPRVSVFLQTIKTQSHRPRIPEEPKLEDVTIGFFSEILMGKRPNTVDELNKLADQWMNILSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYH0</accession>
    <name>B8DYH0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacterioferritin</fullName>
            <ecNumber evidence="2">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582438.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351966.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0011"/>
    <dbReference type="EnsemblBacteria" id="ACK41352">
        <property type="protein sequence ID" value="ACK41352"/>
        <property type="gene ID" value="Dtur_0011"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0011"/>
    <dbReference type="eggNOG" id="COG2193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104506_1_1_0"/>
    <dbReference type="InParanoid" id="B8DYH0"/>
    <dbReference type="OMA" id="TPEMLKC"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006880">
        <property type="term" value="P:intracellular sequestering of iron ion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0409">Iron storage</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="5">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="138" mass="16026" checksum="97BC6F0A2C777EC0" modified="2009-03-03" version="1">MASKELLDLLNDAIARELQVSIQYMWQHVQWKGAEHFAVKDELKKIAIQEMKHAESIAERLFYLGGIPTTKPSPIFIGETLKEMLEQDVKDEQNAIELYKKIIQKAREEGDITTAKLFEDILKDEEEHHDTFTSLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYH2</accession>
    <name>B8DYH2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT</fullName>
            <ecNumber evidence="1">6.3.5.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murT</name>
        <name evidence="4" type="ordered locus">Dtur_0013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57928"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = ADP + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:59488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:62233"/>
            <dbReference type="ChEBI" id="CHEBI:143132"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with GatD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurT subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.13" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582440.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351968.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0013"/>
    <dbReference type="EnsemblBacteria" id="ACK41354">
        <property type="protein sequence ID" value="ACK41354"/>
        <property type="gene ID" value="Dtur_0013"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0013"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.13"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041534_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYH2"/>
    <dbReference type="OMA" id="WLWDVDY"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140282">
        <property type="term" value="F:carbon-nitrogen ligase activity on lipid II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02214">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043703">
        <property type="entry name" value="Lipid_II_synth_MurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013564">
        <property type="entry name" value="MurT_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08353">
        <property type="entry name" value="MurT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="2">
        <location>
            <begin position="58"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="MurT_C" evidence="3">
        <location>
            <begin position="319"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="444" mass="51229" checksum="DC3D2CEEDC14FE0A" modified="2009-03-03" version="1">MSLKKFRFYFALFVGKLIYYSMKILNLDATTFPGKVALKIYPDFLKEISKRIGIRILITGTNGKTTTNNLLNYVIRSKGYKVIGNLEGANLKSGIATSYIKNSGVFDFGTFEVDEGVFPYVYKDLLPQYVVITNFFRDQLDRYGEIDITVNKILNSIKENTTLILNADDPFVARFSRLSNRKIFYGIGVKIREGVEGIKESIYCPFCGRKLNYEFFNYSQLGKYSCECGFKNPEYDFYISSAHLNGIWTIEISEKSKKYDLTFKYPGVYNLYNVLSAYSILRFLNFDPLETSNIISKFEFKLGRLERFIYRGFDRIIVLVKNPAGYNQVLDTIKDDKEEKVLLLILNDNIADGRDVSWIWDVDFEKINDLKGIQKIIVSGTRGEDLLVRLKYAEIPREKLQLEENLKKAIDYSISFPCKTYILPTYTALFKSRKILIGKVKDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYI3</accession>
    <name>B8DYI3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0024</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582451.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351979.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0024"/>
    <dbReference type="EnsemblBacteria" id="ACK41365">
        <property type="protein sequence ID" value="ACK41365"/>
        <property type="gene ID" value="Dtur_0024"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0024"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677451_0_0_0"/>
    <dbReference type="OMA" id="LANEEHH"/>
    <dbReference type="OrthoDB" id="1733145at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
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        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
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        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
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        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="406" mass="46171" checksum="3E82EA32130CDAA5" modified="2009-03-03" version="1">MERFNKNRFIAFIDPALFINGMIFLNINTVIPYFLLSLSASSFHISFANFLVTLGSFLPSLFVARFVQKLRVKTKVFAKLLFIQRLSFLLFSFFLPFLIKSLGNTFTIYMFLLFYGIFNMFVGTYGPFYFSIINKILPYGERGKIIGRGSAVGNLVAILTTYLLNFYLNRFSFPYNFVLIFFTGMIILFIDAVLFYIIDEPEEETQEEALPLGVFLLRAFSFLKRDLNFKRLVFSFIFLGLSLTSLPYFIVYATKSFKGYNFVTIFNLVAIIVSILGNYILGELTKILGYKKVLSLGILLGILGLFLALIFKDIYFLLSGFALLNLTFVSNILTTGFLITSISPKEDLPVYLALSNTLTMSISSLMHIANGFIINYVGFEALFLISLIFLVISLFSMERVVTTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYI7</accession>
    <name>B8DYI7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351983.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0031"/>
    <dbReference type="EnsemblBacteria" id="ACK41369">
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        <property type="gene ID" value="Dtur_0031"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0031"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.32"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="1793376at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016301">
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    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="289"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="555" mass="64378" checksum="F91B593336EBA5D2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYJ2</accession>
    <name>B8DYJ2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351988.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0036"/>
    <dbReference type="EnsemblBacteria" id="ACK41374">
        <property type="protein sequence ID" value="ACK41374"/>
        <property type="gene ID" value="Dtur_0036"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0036"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OMA" id="HIHDNMG"/>
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    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphoric diester hydrolase activity"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
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    </dbReference>
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        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="264" mass="30345" checksum="13B8899BE60224F3" modified="2009-03-03" version="1">MKIGFSFLSLKTLSVKRAISITKKLGGNTLELFGDLVLFYRGKFCEKPESIKEFAVKNDIFLTMHLPYIDINLASFNDEIWEKSIESILKAIEYGEKAGIKRAVLHPGGVPLSHLVLIFLAQRRLRKALEFILEKAEKYDVEVCIENPYFEENDIFSNVDQFYKFIKGFGGKLKVCFDFGHAHISKKGIDYSLNLLKPFITHVHIHDNHGEKDEHLSLGKGSIDFKKYLDFLRNFDGTIILEINSLKDKREDLKRSVEIIKGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYK0</accession>
    <name>B8DYK0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582468.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351996.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0044"/>
    <dbReference type="EnsemblBacteria" id="ACK41382">
        <property type="protein sequence ID" value="ACK41382"/>
        <property type="gene ID" value="Dtur_0044"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0044"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1522430_0_0_0"/>
    <dbReference type="OMA" id="TWPRFPK"/>
    <dbReference type="OrthoDB" id="1904997at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="174" mass="20029" checksum="8331C395F708A9CC" modified="2009-03-03" version="1">MPILKTIANTLTISRFIIGFIIASIGNIQRKLGLKNAILWLILAWITDVLDGYLARTSKMPEDFIGKHDIYADMTVSAGVLYFLTISNFISWKFTLIFVITAVFLIWYLKEKAVTDGIQAVPYALIIYTSLKYDPSYGYLIIAYLLFLIFITWPRFPKEKVPEFINGIRNIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYK9</accession>
    <name>B8DYK9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582477.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352005.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0053"/>
    <dbReference type="EnsemblBacteria" id="ACK41391">
        <property type="protein sequence ID" value="ACK41391"/>
        <property type="gene ID" value="Dtur_0053"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0053"/>
    <dbReference type="eggNOG" id="COG4223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_920357_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYK9"/>
    <dbReference type="OMA" id="LWHSPEA"/>
    <dbReference type="OrthoDB" id="994822at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="288" mass="33337" checksum="B19BE7BADC6B2DC4" modified="2009-03-03" version="1">MEWKKISFGKRELCYEITLNDVKMVITADVGPRIIFFGFKNGENVLFHDTEERLSIGEMKIYGGHRFWISPETKFTYSPDNNPCRVIEDKDKISFVSYDPITEIEKNLTILERNGRFVVRHILENKGKLLYQGAIWALTCIPPKKGIIFFPWGTLGEWKLKKVIYWQKWAGEATTNVKSSQFVPEDDLFLIYPSGETGKVGTTGYEGFVGVTTENYTFIKKFNFVEGAIYPDDNCAIQVYTSENFCELETLSPLYTFNPGISYIHDEEWILLPYKVDPKKGDEIRKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYL9</accession>
    <name>B8DYL9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WYL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582487.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352015.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0063"/>
    <dbReference type="EnsemblBacteria" id="ACK41401">
        <property type="protein sequence ID" value="ACK41401"/>
        <property type="gene ID" value="Dtur_0063"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0063"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_4_1_0"/>
    <dbReference type="InParanoid" id="B8DYL9"/>
    <dbReference type="OMA" id="KTIDKCL"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WYL" evidence="1">
        <location>
            <begin position="162"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="339" mass="40700" checksum="9478855AFDF1F689" modified="2009-03-03" version="1">MSKTVSSNRKLAFRKMLPRIYRIFSLIKENKYISLDEITRKISYEFGETSVRTIKRDIKTLRDDFKMPIAYSKANGGYYLFSKSEFPFPKLTEGEVLSLLITANMLHQFKGTDFEEDFERLKNKLELFLRDNNVIPSDSIESALSIPFTFIKPKVDIRDKFVKILKAIRERKSIIIEYHSFSSDKITERKVDPYHLYNFEGVWYFCGYCHLRKEIRDFALDRIKNIRETYEEFRKPRDFNVYEYIKSAFRINKGEVERIRIKFDPYQARWIKERIWHETQSIEELPDGSIIYEIMANREEIKRWVMGYGAHAEVLEPESLRNEIKKEIRRLGMIYGVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYM8</accession>
    <name>B8DYM8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ordered locus">Dtur_0072</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582496.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352024.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0072"/>
    <dbReference type="EnsemblBacteria" id="ACK41410">
        <property type="protein sequence ID" value="ACK41410"/>
        <property type="gene ID" value="Dtur_0072"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0072"/>
    <dbReference type="eggNOG" id="COG0170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703348_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYM8"/>
    <dbReference type="OMA" id="FWRILAR"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="410" mass="46658" checksum="529DCAB6FC51A8E5" modified="2009-03-03" version="1">MVIIENLIKAIFSALLGYLFGSFLPGYFLPLWFKKVDIRKLGDGNPGVLNVKRSIGIFPAILTAIYDVSKGFVSMILLKYLFNFPNFFVYLGGFSAVLGHKFPFYLGFRGGRGFATSLSLFIFLFFKLLIQNFASFQILQFFIFLIVYFLLLNTATHGVGDVFTITAFPIIALFMLINTKSLLDTIFLAILAGVISYEAVKNLLRDGFRFYTEKHTFWRILARPFALLFIPIYVFFSKFIVLLVIGGILGIFFLLDMLRILVRRMEDFFQLRGVKNFKIFKEKEVGRISSITNFLLGIFISFILFEKEIAFASLGFTSLGDMMAKWIGINFGKTKIFKNSEKTLEGSLGFFSMALVVSFFLWFKGMISLYVLLVGTIVAFIVEAIPNPIDDNFSVPIISGAVMEFIKKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYP4</accession>
    <name>B8DYP4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase assembly chaperone hypC/hupF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582512.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352040.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0088"/>
    <dbReference type="EnsemblBacteria" id="ACK41426">
        <property type="protein sequence ID" value="ACK41426"/>
        <property type="gene ID" value="Dtur_0088"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0088"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.89"/>
    <dbReference type="eggNOG" id="COG0298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159381_2_2_0"/>
    <dbReference type="InParanoid" id="B8DYP4"/>
    <dbReference type="OMA" id="MCLAIPC"/>
    <dbReference type="OrthoDB" id="2031925at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902670">
        <property type="term" value="F:carbon dioxide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="71" mass="7576" checksum="27B278DA0353B262" modified="2009-03-03" version="1">MCLGVPLRIVEVKEGNIAIADMGGSTLEISTIFTPEVKVGDYVLVHAGFSISILSNEEAEEIISALGELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYQ1</accession>
    <name>B8DYQ1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0095</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582519.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352047.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0095"/>
    <dbReference type="EnsemblBacteria" id="ACK41433">
        <property type="protein sequence ID" value="ACK41433"/>
        <property type="gene ID" value="Dtur_0095"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0095"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.98"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="InParanoid" id="B8DYQ1"/>
    <dbReference type="OMA" id="NVFQQCV"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="310" mass="35160" checksum="C432883FCCC5E71A" modified="2009-03-03" version="1">MNNFKFIVEVENLKKYYGNVKAVDGVSFKIKQGSIFTLLGPNGAGKTTTLEIIEGLRTPDSGKITIFGRQVEKIGREEKELIGVSLQETNLIGNLTVKETFSMFRSFYKKGLRVDDVLDFVSLKDKAKSYVDKLSGGQRQRLAIGLALINDPLLLFLDEPTTGLDPQARRSIWDLLLQLKKQGKTIVLTTHYMEEAEFLSDWVCIMDHGKIIREGTPEDLIKSIGGESVIEVDVEEDGEFLRELENMGLNYTFNAKHRRLILKTNNVLETIDILLRAAKKRGINIRNEIIRQPNLEDVFLTLTGKQLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYQ7</accession>
    <name>B8DYQ7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582525.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352053.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41439">
        <property type="protein sequence ID" value="ACK41439"/>
        <property type="gene ID" value="Dtur_0103"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0103"/>
    <dbReference type="eggNOG" id="COG1895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151247_3_0_0"/>
    <dbReference type="InParanoid" id="B8DYQ7"/>
    <dbReference type="OMA" id="YYAMFYA"/>
    <dbReference type="OrthoDB" id="2022823at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="134" mass="15905" checksum="6F5EAB2317AD018B" modified="2009-03-03" version="1">MKDENIRLNVKEEIERAKEAHKSANILFENGLIKDAISRLYYYTLHMVRALLFTKGFEPKSHEGALRLLSLHFIKEGIFEPEIAHIFSRLMKYREEADYNPFYVFSKEDFLSYKEEAEKLAGEIERYLRKIGLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYT1</accession>
    <name>ATPG_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpG</name>
        <name type="ordered locus">Dtur_0131</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582548.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352077.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DYT1"/>
    <dbReference type="SMR" id="B8DYT1"/>
    <dbReference type="STRING" id="515635.Dtur_0131"/>
    <dbReference type="EnsemblBacteria" id="ACK41463">
        <property type="protein sequence ID" value="ACK41463"/>
        <property type="gene ID" value="Dtur_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0131"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYT1"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000134141" description="ATP synthase gamma chain">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <sequence length="290" mass="34211" checksum="DC0160A7A57520EF" modified="2009-03-03" version="1">MPTLQGLRRKVKTIQNISHIIHSMETLSMVKIRALQDKSLRLKPYTEELNNILMELITRLPNEYLNHPLIRERSVYKTGILVFTSDLGFCGSYNLQIIESLKKFIEGKRAQNLVFYSIGFYAQRYLSSNNFNIRKKYIKFLEDTSFSQAKILSKDLLDDFLNYVIDELYVIYFEFINIVKQEVRIKKILPMIPVEVKERKEEYFLFLPSLSSILDPLLMDIFETQIHQIMLDSAASEQAFRRFAMKRAYDNAQKLHSKLIFQLNQLRQTQITKELLDITSSIEAMKEEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYT5</accession>
    <name>B8DYT5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ordered locus">Dtur_0135</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582552.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352081.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0135"/>
    <dbReference type="EnsemblBacteria" id="ACK41467">
        <property type="protein sequence ID" value="ACK41467"/>
        <property type="gene ID" value="Dtur_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0135"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.140"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_2_2_0"/>
    <dbReference type="OMA" id="FTHAVRL"/>
    <dbReference type="OrthoDB" id="867266at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK41467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="220" mass="24493" checksum="84EF131AEF51A78C" modified="2009-03-03" version="1">MERGPEIGPRVVGQIFGIPITNTLISLQIVSLFVILLAFWLSYKPKETITTRQNIAETLVEMFKRYLSGFLEEHIAEKYFSFFATLFLFILISNWSGFIPGFTSPTSDINVTAGLAIGTILYIQYVAFKERGVEYLKSFVSPSVLFLPINILEQITRPVSLALRLFGNISGEHIVLGIISLLAPLIVPVPIMALNMFMGFIQAFIFTSLSAAYLAAALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYV3</accession>
    <name>B8DYV3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0154</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582570.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352099.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0154"/>
    <dbReference type="EnsemblBacteria" id="ACK41485">
        <property type="protein sequence ID" value="ACK41485"/>
        <property type="gene ID" value="Dtur_0154"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0154"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="InParanoid" id="B8DYV3"/>
    <dbReference type="OMA" id="QLWGYPP"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="220" mass="25379" checksum="4886B5B6AB747B49" modified="2009-03-03" version="1">MKILVVEDDRKISHLLELELTHEGHEVKVVGDGYDALIEVEDFKPDVVILDIMLPGLSGKEVAKRLRDKYPDLGIIMLTALGDVKDKVEAFKLGADDYVVKPFSIEELLARIQAVSRRKEKKEEIISKHGIELYVDQHRVFIDGKEVELSKTEFSLLYLLLKNENIVLSKEKILSSIWGDYDDERENLVEVYINYLRKKLGERGKYIKTIRGVGYSFRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYV6</accession>
    <name>B8DYV6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582573.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352102.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0157"/>
    <dbReference type="CAZy" id="GH4">
        <property type="family name" value="Glycoside Hydrolase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41488">
        <property type="protein sequence ID" value="ACK41488"/>
        <property type="gene ID" value="Dtur_0157"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0157"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_0"/>
    <dbReference type="OMA" id="CHEVFST"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="193"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="452" mass="52332" checksum="3318468B1CE5B209" modified="2009-03-03" version="1">MVKIAIIGAGSVSFSMKLLQDLNYYKDLSGSTVVFMDINEERLELVYTLAEKYMKETGARLNLEKTTDRKKAIDGADFVINVVKIGGYHNMEKEREIAESLGYYRGFGDRVSDYYGGFAAYEQLKFIRELAKDVEKLAPNAWYMQVSNPVFEGTNLALRETGLKVVGFCHGYLELFHLIRVLGLDPKDVEEQVAGFNHSIFLTKFKYKGENAYPLIDKWIEEEAPKLWNSYEYMISPWEYTQLSPASVEMYRLYGLFPIGDTPRAVSPWWFHTDLNEKKKWYPAGGPDSEIGWTMYLYGLKLRLAQMERLARDPNVSIVKELPVEESMESIIPFVDAIVNNHRRRLVLNVPNQGAIPGIPDDVIVEIPVYVDKNGIERERIEKIPSRLMLYVLIPRWLRMERILQAFQEGDRTSLLLMVMDDPRTKSFEQGKNLVETILSQPWNEEMNKHYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYY7</accession>
    <name>B8DYY7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582698.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352227.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0290"/>
    <dbReference type="EnsemblBacteria" id="ACK41613">
        <property type="protein sequence ID" value="ACK41613"/>
        <property type="gene ID" value="Dtur_0290"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0290"/>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_2_0"/>
    <dbReference type="InParanoid" id="B8DYY7"/>
    <dbReference type="OMA" id="VSAMHIT"/>
    <dbReference type="OrthoDB" id="1691156at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="138" mass="16057" checksum="E2DC7E64F4560619" modified="2009-03-03" version="1">MKSYRKELWFELPTRRGFVNITDTLQRCVEESGIKEGLLLCNAMHITASVFINDDEPGLLEDFEIWLEKLAPEKPYNQYYHNVGENNADAHLKRTIMGREVVIAITNGKLDLGPWEQVFYGEFDGRRRKRVLVKIIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYZ3</accession>
    <name>B8DYZ3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582704.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352233.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0297"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41619">
        <property type="protein sequence ID" value="ACK41619"/>
        <property type="gene ID" value="Dtur_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0297"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_0"/>
    <dbReference type="InParanoid" id="B8DYZ3"/>
    <dbReference type="OMA" id="RSWENSA"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="192"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="389" mass="44775" checksum="5563C520CD9E7D92" modified="2009-03-03" version="1">MIVGLFNDSFPPIMDGVAIAVKNYAYYINKKYGKAYVITPSFPGYKDKEEYEVIRYFSIPVILRPPYRFGVPFLDIKVVKKIESIPFDIIHVHSPFSSGILGLYIARKKKIPIVASFHTKYYDDFKEATKSDFLAKIGVKIIVEFYHRVDEVWTVNSATAKTLKEYGFKKDIKIVPNGTDFFPLENLGDYKNKINRIHNLSEEDTVILFVGQMVRQKNVELLLRSLSILKEDNVNFKAIFVGTGKDEDYFKRLAEELKIKDKVIFTGKIFDRELLKAYYARANLLAFPSLYDTSALVIKEASAMGCPSLLIKGSTVAEGEGVIDGFNGFLSENDHITYARKMKEILSQKEFLKKVGENARKTLYKHWEEIVDEVVGNYRELIEKYKKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ07</accession>
    <name>B8DZ07_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582718.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352247.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0311"/>
    <dbReference type="EnsemblBacteria" id="ACK41633">
        <property type="protein sequence ID" value="ACK41633"/>
        <property type="gene ID" value="Dtur_0311"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0311"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.328"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZ07"/>
    <dbReference type="OMA" id="QFIMVAR"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="296" mass="33207" checksum="15A3F831656EF708" modified="2009-03-03" version="1">MKRSLGEKTFDIVNYGLMILLVIITLYPFLYVLAVSLNDPFDTIKGGITIFPRIFTLDNYKEIFNYPSIGRAALISTLRTIIGTIIGVFSTAIVAYVLSRRDFFARKLITTLFVITMYVGGGLVPEYLLIRGLGLMNNFLVYILPGLINPFNLILIRAYIDTLPSELQESAMIDGANDFIIFLKIILPLSLPVLATVALFVAVGHWNSWFDTYLYCGGNKNLTTLQYELQKILANAAASSTTIDYYSNLDPTRTMRVTPQSLRMAMTIITTLPIVLVYPFLQKYFIKGMTLGAIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ22</accession>
    <name>B8DZ22_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582733.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352262.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0334"/>
    <dbReference type="EnsemblBacteria" id="ACK41648">
        <property type="protein sequence ID" value="ACK41648"/>
        <property type="gene ID" value="Dtur_0334"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0334"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.354"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_4_0"/>
    <dbReference type="InParanoid" id="B8DZ22"/>
    <dbReference type="OMA" id="PGELMDY"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="12"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="396" mass="43831" checksum="AF6F986050A1FF5B" modified="2009-03-03" version="1">MKENLNFPYFMPTKIWFGPGSLEKLREEKLPGKKALIVISAGGSMKKLGYLDRLIDILKSRRVEYVVFDKILPNPIKKHVMEGAQIAREEECDFVIGLGGGSSIDSAKSIALMVKNDGDYWDYIVGGTGKGKKPEKGALPIVAITTTAGTGTEADPWTVITNEETNEKIGYGNEYTFPTLSIVDPELMLSVPPHLTAYQGFDAFFHAVEGYIANIANPVSDLYALKSVELIAKYLPICVKNGNDLIARTYVALANTLSGFVESTSSCTSEHSMEHALSAFHPELPHGAGLIMLSEAYHTFFASKIPDRYIQLAKVMGLDVDSLPEEEKPYAFIKALKKLQEECGVANLRMSDYGIKEDEIEKLAQNAIETMGGLFEMDRYKLSFDEVVEILRKAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ25</accession>
    <name>B8DZ25_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582736.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352265.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0337"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41651">
        <property type="protein sequence ID" value="ACK41651"/>
        <property type="gene ID" value="Dtur_0337"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0337"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZ25"/>
    <dbReference type="OMA" id="YLLMTVD"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="349" mass="41130" checksum="FEDE443262BE533B" modified="2009-03-03" version="1">MRIILFLIFWLIGWVYYKSLRFLKKEGEISGEYKVSVIIPARNEEKNLDKLLYLLQKQTYKPYEVIVVNDNSEDNTEEVAKRYGVKVVSLYEDPPEGWVGKNWAIWNGYLESRGEILLFLDADVEPREEFIEVMLSNYEKYGGLISCWPYQRFEKFYEHLNLGFNLVSVFSMTLFGKKEGAFGPSMMISREYYEKVGGHKEVRDKVVEDLHFGNLCIKKGVPVNNFLGGEYIKFRMYPKGLKDLIQGFTKNIAKGAFSISLLNFLLVFLYITGVYGSIFYFRSTVLNFLYALYATQLFAIQRRLGDYKWYDAFFYPLHFLFFFSIFLYSIIRIFFVKAVIWKGRKIRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ41</accession>
    <name>B8DZ41_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352281.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0356"/>
    <dbReference type="EnsemblBacteria" id="ACK41667">
        <property type="protein sequence ID" value="ACK41667"/>
        <property type="gene ID" value="Dtur_0356"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0356"/>
    <dbReference type="eggNOG" id="COG1033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007352_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ41"/>
    <dbReference type="OMA" id="SLMFAHI"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="561"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="652"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="156"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="7">
        <location>
            <begin position="466"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="685" mass="78264" checksum="DECD30791DD82B7D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ42</accession>
    <name>B8DZ42_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352282.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0357"/>
    <dbReference type="EnsemblBacteria" id="ACK41668">
        <property type="protein sequence ID" value="ACK41668"/>
        <property type="gene ID" value="Dtur_0357"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0357"/>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_610761_0_0_0"/>
    <dbReference type="OMA" id="FRIVMST"/>
    <dbReference type="OrthoDB" id="408193at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="448" mass="51408" checksum="A95A88E7F116CDA8" modified="2009-03-03" version="1">MKRAFIIGVIFLLLIGLSLGNSLKIKNDETVYVLLDYDGKAKKVDLVNWIEVQGQGGFEIVKDARYIKNPDLYSEDVKMDFTKDKIRFYGNVKEVKNIYYKAEVNRKLPLEFKFTYKYNGKVASPKEFLGKSGNLDIEIYIKPIEDLPFRIVMSTEFPSDDLILRNPEDFMVMVLGKTVRVTGFTYPIPDGKIILSLKSNKLKVPDITFTALPSLPPVDLSTGEKLKEFYNGLEGFLMLNQAHQKILKGILESLEKNTLSIPQEFLTLPFTLMSYQNKAYFISDSLKTYPKSFNNLYEFIKSKAEGSKEEDWKKALSLAEEVKKEIEENNMSDDVKKIGDFLADLNFQSKKAMDLLSASLEGLQKMEELLNTILYGGEIEGKKLPGLVDVEKNMKKSKDTLKSNLMELEKGEKKLKEWENKLKDYNFAGRIEGAKSIVRFYFKLKEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ47</accession>
    <name>B8DZ47_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoketolase</fullName>
            <ecNumber evidence="6">4.1.2.9</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.9" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582758.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352287.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0362"/>
    <dbReference type="EnsemblBacteria" id="ACK41673">
        <property type="protein sequence ID" value="ACK41673"/>
        <property type="gene ID" value="Dtur_0362"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0362"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.382"/>
    <dbReference type="eggNOG" id="COG3957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013954_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZ47"/>
    <dbReference type="OMA" id="EHMCQGF"/>
    <dbReference type="OrthoDB" id="45239at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050193">
        <property type="term" value="F:phosphoketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PTHR31273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XFP_N" evidence="5">
        <location>
            <begin position="2"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="XFP_C" evidence="4">
        <location>
            <begin position="575"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="792" mass="90272" checksum="73B6827EE8783912" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ52</accession>
    <name>B8DZ52_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate-binding family 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582763.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352292.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0374"/>
    <dbReference type="CAZy" id="CBM9">
        <property type="family name" value="Carbohydrate-Binding Module Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41678">
        <property type="protein sequence ID" value="ACK41678"/>
        <property type="gene ID" value="Dtur_0374"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0374"/>
    <dbReference type="eggNOG" id="COG3868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097242_0_0_0"/>
    <dbReference type="OrthoDB" id="1997167at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="1">
        <location>
            <begin position="73"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="253" mass="28793" checksum="B00F1A370E0E69E8" modified="2009-03-03" version="1">MKRFLLVLSLVLLLTLTLSFAEDIKLRKGTWTHYVPYTTTPPTIDGDIKISEYFLSPRYYVGLKGDVDYIPENWNGPNDLSVYYYMLWDKTYLYIGAVLKDDSIVQLATGENMWQGDHIEIWFDTDLQSDFEDNKNNKDDYQLGISPGDFELLSPEIWVWTPPVLADEVKKAKIAVKRTNDGYTVEVAIPWSLIKVKPEPDLIMGFAFSPSDTDTPGKLDQEMMMSSAPGASPNWGNPTFWGNLILVDPLGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ56</accession>
    <name>B8DZ56_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582767.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352296.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0378"/>
    <dbReference type="EnsemblBacteria" id="ACK41682">
        <property type="protein sequence ID" value="ACK41682"/>
        <property type="gene ID" value="Dtur_0378"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0378"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_0"/>
    <dbReference type="InParanoid" id="B8DZ56"/>
    <dbReference type="OMA" id="YQEENSW"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870977" evidence="1">
        <location>
            <begin position="21"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="420" mass="48450" checksum="8D5B075C9BE0445D" modified="2009-03-03" version="1">MKKFLIFSFLIILLSLSALGQSKIQITYMRWGDIREIEVERKIVDAFNQSQNKIFVNLESTAWGAYWQQLQNRIAAGNAPDVILMDGAYFIDLASKGVFKDITEWIRRDINLKNYYYDPEVCEWDGKIYAMIRDITLGGIMFYNKDIFDKYKIKYPDWSWDWNKWIEAAQKLTIDENKDGTPEIWGTYVPTWGEGGLYPIIWSAGGTVLSKDKKSCTIYSNPKSLEGLKFMYELRYKYKVCPSESFMQGLSDPFMTGNFATTLGISSFIVSYRKLPFRWGIAPIPSGPAGRFMSANQLSLAIYSKSKYPEAAWEFIKFATGPKGQEIMGKEHQAIPALKLKTRVYFDDPNIKSALTIFSLYEKGQLKSLEFTPSWLEWNNMLETTLGYAWQGKVDIEKAAKTAEDRVNKILQEAWKKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ94</accession>
    <name>B8DZ94_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582912.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352441.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0537"/>
    <dbReference type="EnsemblBacteria" id="ACK41827">
        <property type="protein sequence ID" value="ACK41827"/>
        <property type="gene ID" value="Dtur_0537"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0537"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_0"/>
    <dbReference type="InParanoid" id="B8DZ94"/>
    <dbReference type="OMA" id="KARKYEV"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="224" mass="25870" checksum="E0810B0602DDBCC3" modified="2009-03-03" version="1">MKILIIEDEKKLGTALKKGLEKEGYVVDLAFDGEEAKYIIENNFEGYDLVILDIMLPKIDGISLCKDLRAKNFQAPILMLTAKDKVEDKILGLESGADDYLVKPFSYEELLARIRALLRRPKNLMPTVLKVKDISLDTVSKRVFRGDIEILLTNKEFAILEYLMRNVNRIISKEQIISHVWGYESDTLSNVVEAHIKNLRKKLERKRDENIIETIRGMGYRIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ95</accession>
    <name>B8DZ95_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582913.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352442.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0538"/>
    <dbReference type="EnsemblBacteria" id="ACK41828">
        <property type="protein sequence ID" value="ACK41828"/>
        <property type="gene ID" value="Dtur_0538"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0538"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_0"/>
    <dbReference type="InParanoid" id="B8DZ95"/>
    <dbReference type="OMA" id="WDRGKGI"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016036">
        <property type="term" value="P:cellular response to phosphate starvation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="3">
        <location>
            <begin position="121"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="336" mass="38707" checksum="FD59FE15B8868A8F" modified="2009-03-03" version="1">MKILLRPLGEWVIGLRSNIFIKSRIKLTLVYIIITLFILIFFSYLLYTNYSREVEGDFEGDISDKEQLVLAQRSLERLRIQIVMVSGITLGLVGIVSFILSGITLKPIKENMERERKFISDVAHELRTPLAIMKTELEVSLKDPKINKKQLLSVLQSNLEEVERLTKLAEDLLYIFRLEINEVDSNLERISIKDISEKVIKLMTPYAKKKEIDIELQASEDLYILGNPEEIRRILFNLIKNAIDYNKYKGKVKVRFIKDNKYLVLEIEDTGIGIPKDEIPLIFNRFYRVDKSRSSQIQGTGLGLSIVKGIVDKYNGKIIVESKLGEGTIFKILLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZD3</accession>
    <name>B8DZD3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transferase hexapeptide repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582951.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352480.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0577"/>
    <dbReference type="EnsemblBacteria" id="ACK41866">
        <property type="protein sequence ID" value="ACK41866"/>
        <property type="gene ID" value="Dtur_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0577"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.613"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_9_1_0"/>
    <dbReference type="InParanoid" id="B8DZD3"/>
    <dbReference type="OMA" id="WPGRRVI"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="194" mass="21059" checksum="1EA429B68C14274B" modified="2009-03-03" version="1">MSKDLHYFVHESSYVDEGVEIGEGTKIWHFCHILRGSKIGKNCVLGQNVMVGPNVKIGNNVKIQNNVSVYEGVEIEDDVFCGPSCVFTNVINPRAFIERKNEFKKTKVKKGATIGANATIVCGVTIGEYAFVGAGAVVTKDVPPYALVVGVPARQIGWVCKCGVRLEFDDNGKAVCKACGEKYRLEDGRLVSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZE4</accession>
    <name>B8DZE4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0589</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582962.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352491.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0589"/>
    <dbReference type="EnsemblBacteria" id="ACK41877">
        <property type="protein sequence ID" value="ACK41877"/>
        <property type="gene ID" value="Dtur_0589"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0589"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_8_3_0"/>
    <dbReference type="InParanoid" id="B8DZE4"/>
    <dbReference type="OMA" id="NDYLANH"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="224" mass="26260" checksum="36DF08E21A529FE4" modified="2009-03-03" version="1">MIRLIIFDLDDTLYPEIEFVMSGFKAVAKAISQDFDFDTNKIYALLIEAFKEDKKFVFNRVLKYLKIYNEDYLNKLIFLYRTHNPEIHLYKDAEEMLPYLKEHFLLGLITDGFPTTQRLKVEALNIERYFDGIIYTGEKGENYSKPSIFPFIDMLNEFHIQSDEAIYIGDNIEKDFKGPKALGMVSIRVIRNGIYKNSISPGKDFDPDYVINSLFELDNLLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZI0</accession>
    <name>B8DZI0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR-associated endoribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582998.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352527.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0625"/>
    <dbReference type="EnsemblBacteria" id="ACK41913">
        <property type="protein sequence ID" value="ACK41913"/>
        <property type="gene ID" value="Dtur_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0625"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.662"/>
    <dbReference type="eggNOG" id="COG1583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089858_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZI0"/>
    <dbReference type="OMA" id="HWDLYPH"/>
    <dbReference type="OrthoDB" id="908607at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010156">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045747">
        <property type="entry name" value="CRISPR-assoc_prot_Cas6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36984">
        <property type="entry name" value="PTHR36984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01881">
        <property type="entry name" value="Cas_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005054">
        <property type="entry name" value="PF1131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01877">
        <property type="entry name" value="cas_cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005054-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005054-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="256" mass="29857" checksum="545DA792C8460985" modified="2009-03-03" version="1">MRIKITYETLDGDIVLPKHYNHHIQALIYKTFSPQLATNLHNIGFPYGKRRFKLFTFSRILEKGIPTKDDTKLIFKRKITFYFSSPIEDIVENLAERSFKEREFELCGKKIYISQLQIITTPKIEEKVKIKAISPITIYSTLKKADGSKIVHFYKPIDKEFSKLIENNAKKKFHLIYGKDPEELKLEIKPLKFSVKDNLKLVKFKDTIIEGYTGVYELTGSPELIYVTYEAGLGNKNSGGFGMWEIWREKEEDENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZI2</accession>
    <name>B8DZI2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583000.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352529.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0627"/>
    <dbReference type="EnsemblBacteria" id="ACK41915">
        <property type="protein sequence ID" value="ACK41915"/>
        <property type="gene ID" value="Dtur_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0627"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_290653_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZI2"/>
    <dbReference type="OMA" id="MLERWEF"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902201">
        <property type="term" value="P:negative regulation of bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="924"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1052" mass="123905" checksum="31BE2AC6FA65B594" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZJ6</accession>
    <name>B8DZJ6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0644</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583014.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352543.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0644"/>
    <dbReference type="EnsemblBacteria" id="ACK41929">
        <property type="protein sequence ID" value="ACK41929"/>
        <property type="gene ID" value="Dtur_0644"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0644"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_4_1_0"/>
    <dbReference type="InParanoid" id="B8DZJ6"/>
    <dbReference type="OMA" id="WSINAVV"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="6"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="152"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="287" mass="32236" checksum="3ACF18EFB1744707" modified="2009-03-03" version="1">MKEKLIGLTLVIIACLFWSISFSVSKLLLKILSPFELAFIRFFLASIFSLIVFFPKIRKASLSWNYQKPLFIAGLLGVTLYFIFENSGLKFTDASEGALIVGSFPALGLLVEYLFHREKLPLNRILGVLLSILGVFLIMSDSGLNLKFNNLFGDFLILLSGISWVIYNWEIKRVNQNYPHEVITTFQMIWGSILFIPFLFSTGLKIPKTLDAFIGIFFLAFFCSGLGYLFYNHGLKILSVSQVVNILNLIPLFGAIWGVIYLNESLTFIKIIGGVLIILGVSISSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZJ8</accession>
    <name>B8DZJ8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myo-inositol catabolism IolB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583016.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352545.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0646"/>
    <dbReference type="EnsemblBacteria" id="ACK41931">
        <property type="protein sequence ID" value="ACK41931"/>
        <property type="gene ID" value="Dtur_0646"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0646"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.684"/>
    <dbReference type="eggNOG" id="COG3718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066438_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZJ8"/>
    <dbReference type="OMA" id="HGYDLYY"/>
    <dbReference type="OrthoDB" id="1047507at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024203">
        <property type="entry name" value="Deoxy-glucuronate_isom_IolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021120">
        <property type="entry name" value="KduI/IolB_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39193">
        <property type="entry name" value="PTHR39193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04962">
        <property type="entry name" value="KduI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036628">
        <property type="entry name" value="IolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04378">
        <property type="entry name" value="myo_inos_iolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="268" mass="31030" checksum="B36D8E28E30EAADF" modified="2009-03-03" version="1">MFRKVNLQWGLNILVKPGEMQFIELDIFKGQKGDSYNFNSRDYEIGLVILTGKCNVEIDGEMYNSIGARRNVFDGNAYAFYVPNNREVKIEALEPLEVAICKTKVKTDEEVKLIKPSDVVVRDVGVYNWRRDVKDIIDGRIKAKRLLIGETINPPGNWSSYPPHKHDTDNYPEEVRMEEVYFYRVNPPSGFGLQRVYTEEGDINEVFLIENDSLLLIAKGYHPVVAAPGYQLYYLWILAGEIRESVMYDDPKHKWLRAVEKIMKEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZK0</accession>
    <name>B8DZK0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase 36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583018.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352547.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0648"/>
    <dbReference type="CAZy" id="GH94">
        <property type="family name" value="Glycoside Hydrolase Family 94"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41933">
        <property type="protein sequence ID" value="ACK41933"/>
        <property type="gene ID" value="Dtur_0648"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0648"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.686"/>
    <dbReference type="eggNOG" id="COG3459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019054_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZK0"/>
    <dbReference type="OMA" id="FPVGYMS"/>
    <dbReference type="OrthoDB" id="136681at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11755">
        <property type="entry name" value="GH94N_ChBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009342">
        <property type="entry name" value="Carb-bd_put_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033432">
        <property type="entry name" value="GH36_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037828">
        <property type="entry name" value="GH94N_ChBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010383">
        <property type="entry name" value="Glyco_hydrolase_94"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17167">
        <property type="entry name" value="Glyco_hydro_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06165">
        <property type="entry name" value="Glyco_transf_36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01068">
        <property type="entry name" value="CBM_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="764"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="809" mass="93349" checksum="5E96FD0C6ACAEABF" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZK2</accession>
    <name>B8DZK2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583020.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352549.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0650"/>
    <dbReference type="CAZy" id="GH31">
        <property type="family name" value="Glycoside Hydrolase Family 31"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41935">
        <property type="protein sequence ID" value="ACK41935"/>
        <property type="gene ID" value="Dtur_0650"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0650"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_2_0"/>
    <dbReference type="InParanoid" id="B8DZK2"/>
    <dbReference type="OMA" id="LPRGRWY"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032513">
        <property type="entry name" value="AGL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16338">
        <property type="entry name" value="DUF4968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4968" evidence="4">
        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="116"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="5">
        <location>
            <begin position="695"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="776" mass="92354" checksum="34EDB3D710C0219D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZM6</accession>
    <name>B8DZM6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583044.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352573.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0674"/>
    <dbReference type="EnsemblBacteria" id="ACK41959">
        <property type="protein sequence ID" value="ACK41959"/>
        <property type="gene ID" value="Dtur_0674"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0674"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="InParanoid" id="B8DZM6"/>
    <dbReference type="OMA" id="RVMHDLR"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="372"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="589" mass="67014" checksum="FCE5FA9882ED4E5D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZT7</accession>
    <name>B8DZT7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583105.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352634.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0738"/>
    <dbReference type="EnsemblBacteria" id="ACK42020">
        <property type="protein sequence ID" value="ACK42020"/>
        <property type="gene ID" value="Dtur_0738"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0738"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_0"/>
    <dbReference type="InParanoid" id="B8DZT7"/>
    <dbReference type="OMA" id="GSLYRIR"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="23"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="315"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="408" mass="45374" checksum="C75F0C5793225056" modified="2009-03-03" version="1">MKTQLKENLKLALYSLKSNKLRSFLTILGIIIGVFSVVLLISIGEGAKNQTLQIIENLGSNTLIIFPSALETGGTFTSIQIQRTRRGIPQLFNYNDLLYLRALFKNELLVSSLISSYYNVYYQIFPLEATVHGTDNDGLLINRDSISEGRFFTSYEQNAKEKVCIVGPKVAKNIAINYKEAINKIIKIGDHNFRIIGVLKERGYNQSLGDLDSRIIIPLTTALMLKGDQILNFLIVQVRDSKNIEIYRQKLIFVLKQRRGKLNFVIAKQEDLLSAMNDILNILTLTLAGIAAISLIVGGIGIMNIMLVSVTERYKEIGIRKAIGAKKKDILIQFLTESGFLGMIGGTLGIGLSIITGEILSRFEVPYNLSYSTLILGFLFSLFIGLIFGVLPAMRAANLDPIQALRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZU4</accession>
    <name>B8DZU4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0745</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583112.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352641.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0745"/>
    <dbReference type="EnsemblBacteria" id="ACK42027">
        <property type="protein sequence ID" value="ACK42027"/>
        <property type="gene ID" value="Dtur_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0745"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_10_0"/>
    <dbReference type="InParanoid" id="B8DZU4"/>
    <dbReference type="OMA" id="YRHFVVD"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="28"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="309"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="655" mass="77632" checksum="5CA614A0CCB5FFBE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZU5</accession>
    <name>B8DZU5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FeS_assembly_P domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583113.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352642.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0746"/>
    <dbReference type="EnsemblBacteria" id="ACK42028">
        <property type="protein sequence ID" value="ACK42028"/>
        <property type="gene ID" value="Dtur_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0746"/>
    <dbReference type="eggNOG" id="COG2151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_3_0_0"/>
    <dbReference type="InParanoid" id="B8DZU5"/>
    <dbReference type="OMA" id="TVADPHM"/>
    <dbReference type="OrthoDB" id="1922128at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="94" mass="10504" checksum="A40451BC974CE896" modified="2009-03-03" version="1">MNLKEAIENKLKEIIDPEVGLDLVTLNTIDKLEVDNDGNVKIVFRPTTPFCPLGIQLALSIKKAVKEIEGVKNVDIEVVDFIFAEQANELLKNQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZW2</accession>
    <name>LIPB_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Octanoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lipB</name>
        <name type="ordered locus">Dtur_0763</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583130.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352659.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZW2"/>
    <dbReference type="SMR" id="B8DZW2"/>
    <dbReference type="STRING" id="515635.Dtur_0763"/>
    <dbReference type="EnsemblBacteria" id="ACK42045">
        <property type="protein sequence ID" value="ACK42045"/>
        <property type="gene ID" value="Dtur_0763"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0763"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.801"/>
    <dbReference type="eggNOG" id="COG0321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZW2"/>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="OrthoDB" id="1806796at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000201794" description="Octanoyltransferase">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="32"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01067"/>
        </source>
    </evidence>
    <sequence length="232" mass="26780" checksum="A41CA4A7C4C0E10D" modified="2009-03-03" version="1">MKKLLVIDFKEKIKYEDAWNFQRKLHDLRVNNIIYDTLILLEHFPVITLGKFGNESNLLKRKEELEDIGIDFLRVDRGGDITYHGPLQLVGYLIFRVEGVKNFVLKIERSIINVLNEYGIEAKENLKYPGVWVGDRKIAAIGIAIKKKVSYHGFALNVSNDLTPFSYIIPCGLKDKKVTSILKEADFSPSMEDVKKKVCLSVVREFGFDSFKVFNFSSYKELSNFDMLLEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZX4</accession>
    <name>B8DZX4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0775</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583142.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352671.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0775"/>
    <dbReference type="EnsemblBacteria" id="ACK42057">
        <property type="protein sequence ID" value="ACK42057"/>
        <property type="gene ID" value="Dtur_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0775"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.812"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZX4"/>
    <dbReference type="OMA" id="TDFWGSM"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="23"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="113"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="226"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="462" mass="50774" checksum="5FCE0ABBF2B316BA" modified="2009-03-03" version="1">MISKSALEEILDISLSKGGDFSELFFEVNNSLYFYFDDNRLEEAVVGEDIGVGLRVIFGDRTFYGYTTDVSLLGLRKLAQNLAEAVFLRDQNIKVVLSDKKEYGIRPLKDKGSFEIKEVYDILRMMNEKARSYDSRIVQFTSVIRTVDQKVLIANTDGDWVEDRRVRTVVYGLSVGSYNGVIQTGYESIAGMVGWELFTEEVINKIPYEASRRAILLLEAKEAPAGVMPVVISSKAGGVLIHEAVGHGLEADLVDKEVSVYKDKIGEKVASELVTMVDAGVLEGMYGSSGVDDEGVKTNYNVLIDRGVLKGYMHSRITAKKFNVPPSGNGRRQNFRYPPIPRMTNTFILPGESKLEDMLQRLEKGIYVVKMGGGQVDTTSGDFVFAIEEGYFVLNGEIKYPIRGATLIGNGPKVLEKIEMVGNDIGFAPGTCGKDGQGVPVTDGMPTILISEITIGGTEKGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZX8</accession>
    <name>DNLI_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lig</name>
        <name type="ordered locus">Dtur_0780</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583146.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352675.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZX8"/>
    <dbReference type="SMR" id="B8DZX8"/>
    <dbReference type="STRING" id="515635.Dtur_0780"/>
    <dbReference type="EnsemblBacteria" id="ACK42061">
        <property type="protein sequence ID" value="ACK42061"/>
        <property type="gene ID" value="Dtur_0780"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0780"/>
    <dbReference type="eggNOG" id="COG1793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_0_0"/>
    <dbReference type="InParanoid" id="B8DZX8"/>
    <dbReference type="OMA" id="WLFEESY"/>
    <dbReference type="OrthoDB" id="1073940at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006266">
        <property type="term" value="P:DNA ligation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000189919" description="Probable DNA ligase">
        <location>
            <begin position="1"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <sequence length="582" mass="66609" checksum="8F52513B1C69AED3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZZ4</accession>
    <name>B8DZZ4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583162.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352691.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0796"/>
    <dbReference type="EnsemblBacteria" id="ACK42077">
        <property type="protein sequence ID" value="ACK42077"/>
        <property type="gene ID" value="Dtur_0796"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0796"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.834"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZZ4"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="112"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="348" mass="39034" checksum="8D7DDDE8E4CE7DED" modified="2009-03-03" version="1">MDLIFFLILFALLTIPHEFGHFIFAKVFGVRVYEYAVGFGPKILEIKGRETKFVLRLIPIGGFVKMAGVDDINIPEVESVPEDRKFYKKAPWQRFLILFAGSFMNFIFAIILFMAIFLIGIPQPIPVVDKVLENKPASVSGILPGDRILYIDGKKIEDISDAVKLITGSIKSPGEKREIEIKVERDGKIVNIKVVPEWSEERKGGIIGIVFKTVPKRYSLPTAVKNGFLMFINALILIFYVFKALFNGVQGVSIAGPIGIAKMTGEVASMGLIYYLNFLGVLSVQLGVFNLLPIPALDGGRILFVIIEKIRGKPIETKKEEMVHWIGLLILLFLMIIVTFFDILNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E007</accession>
    <name>B8E007_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose 5-phosphate isomerase B</fullName>
            <ecNumber evidence="4">5.3.1.26</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.26" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583174.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352704.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0809"/>
    <dbReference type="EnsemblBacteria" id="ACK42090">
        <property type="protein sequence ID" value="ACK42090"/>
        <property type="gene ID" value="Dtur_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0809"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.847"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_1_0"/>
    <dbReference type="InParanoid" id="B8E007"/>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050044">
        <property type="term" value="F:galactose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019316">
        <property type="term" value="P:D-allose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="66"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="148" mass="16640" checksum="F29F0DA0C387929E" modified="2009-03-03" version="1">MKIAIGADHAGYMLKEELKRWLEEWNISYHDFGTYSPERVDYPDYGIIVARAVAKGGFEKGILICGTGIGMSIVANKVKGIRAALCRDPYEAKLSREHNDANILTLGGRILGFDLAKEIVRVWLNTEFTGGRHKVRIDKISMIEEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E026</accession>
    <name>B8E026_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583193.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352723.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0828"/>
    <dbReference type="EnsemblBacteria" id="ACK42109">
        <property type="protein sequence ID" value="ACK42109"/>
        <property type="gene ID" value="Dtur_0828"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0828"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.867"/>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="InParanoid" id="B8E026"/>
    <dbReference type="OMA" id="LPMYQRA"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="239" mass="26753" checksum="97A2894E22178E90" modified="2009-03-03" version="1">MALETVGIYKYYGRRCVVKDVSLTVNPGYVVGLLGPNGAGKTTTFYTIMGEVYADGGKVLLDGEDITSLSMPQRARKGIGYLAQDPTIFRKLTVEENIKLVLELTNLTPKEQRERLEELIDEFQLQKVRKNLGYTLSGGERRRVEIARVLALSPKYILLDEPFAGVDPITVQNLQETIAYLKEKGLGILITDHNVRDTLAITDYAYIIFSGEVLISGTPEEIINSDIAKRFFLGERFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E078</accession>
    <name>B8E078_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Smc1 chromosome segregation protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583245.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352775.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0880"/>
    <dbReference type="EnsemblBacteria" id="ACK42161">
        <property type="protein sequence ID" value="ACK42161"/>
        <property type="gene ID" value="Dtur_0880"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0880"/>
    <dbReference type="HOGENOM" id="CLU_1831973_0_0_0"/>
    <dbReference type="OMA" id="MSEDRWK"/>
    <dbReference type="OrthoDB" id="2130867at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="140" mass="15998" checksum="3D4C34A6B514F6F8" modified="2009-03-03" version="1">MSEDRWKKLWESLKPQIASMVQKAGETAQKAGEVVSEMAKTLGKESAKLAKIGKLKADILILEGNKDSLLRNLGEKLYELHKNNEEIRKELFADLITEIEGLEKKILEKQREIESIAREENLKPEDVEKIPAVEDEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0B6</accession>
    <name>B8E0B6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583643.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353175.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1283"/>
    <dbReference type="EnsemblBacteria" id="ACK42561">
        <property type="protein sequence ID" value="ACK42561"/>
        <property type="gene ID" value="Dtur_1283"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1283"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1323"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_1_3_0"/>
    <dbReference type="InParanoid" id="B8E0B6"/>
    <dbReference type="OMA" id="AIDWIYW"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="2"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="328" mass="37316" checksum="82179A0F99E38159" modified="2009-03-03" version="1">MKIVIIGSSGHINYAIEGIGLDKECEVVGVAPGSKGESIDKVLNMLGENFKGKVYGDYEVMLEELSPDVAVVACHFGDIAKVNIKALSYGCHVFTEKPLATTMEDLKALKRVYYQSGKRLCAMFGIRYKPWFFTAYKFVREGAIGEIRLINTQKSYKLGRRDEFYKKRETYGGTIPWVGIHAIDWIHWFTHKRFKTIYATHSRKYNKDHGDLEVTALCHFTLEDEIFASLSIDYLRPENALSHDDDRMRIVGTDGVIEVIFNKVFLTNKDYKNQELPLEGRGNIFVDFLKEIKGNGSCMVTAEESFYATEVALLARQSADKNKIIYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0D6</accession>
    <name>B8E0D6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease YjgP/YjgQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583663.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353195.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1307"/>
    <dbReference type="EnsemblBacteria" id="ACK42581">
        <property type="protein sequence ID" value="ACK42581"/>
        <property type="gene ID" value="Dtur_1307"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1307"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0D6"/>
    <dbReference type="OMA" id="PYSSKQY"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="356" mass="40751" checksum="0170E0B4400BAF9F" modified="2009-03-03" version="1">MKIISRYFLQNFIPVFFVGLLLFTTILLVSPLFIIMDLVVARSIPLKTALELFITKIPPYLTYTFPMAIFLAVVYVIGQFSEHGEIMAMKASGASIKYFLPAILMFSLSAQLIMFYVNEFVAPKAYEREKILMNKAYNNVIMPSRENVFFNENNSFYFFRKVDPKNKKFEDILLIELLEKGNVRLIIHAEKALWDEFKGWTFMNGEVYSLNKEGEMIFQGKFKEYKVTLNRAPYQLVPSSKPVEEMSIFEIVDQIRLLEGTGLNLNNLKTEFHIRIALPFTCPIFAILALGLGLNMGKGGRSLSFGLSVISIFVYYIIFSIGRSLAKAGIVPYFLGAWLGNIVFLIIGIYLLNKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0F4</accession>
    <name>B8E0F4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">Dtur_1325</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583681.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353213.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1325"/>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="EnsemblBacteria" id="ACK42599">
        <property type="protein sequence ID" value="ACK42599"/>
        <property type="gene ID" value="Dtur_1325"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1325"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1370"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_0"/>
    <dbReference type="InParanoid" id="B8E0F4"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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            <begin position="5"/>
            <end position="269"/>
        </location>
    </feature>
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        <location>
            <begin position="302"/>
            <end position="525"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
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    <feature type="region of interest" description="L-glutamine binding" evidence="9">
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            <begin position="382"/>
            <end position="385"/>
        </location>
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        </location>
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        <location>
            <begin position="16"/>
            <end position="21"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
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        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
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        <location>
            <begin position="190"/>
            <end position="195"/>
        </location>
    </feature>
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        </location>
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        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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            <position position="354"/>
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        </ligand>
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        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
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    <feature type="binding site" evidence="9">
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            <position position="461"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
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        <source>
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        <source>
            <dbReference type="EMBL" id="ACK42599.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="536" mass="59957" checksum="599ABE75D93ADDA9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0G4</accession>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0H1</accession>
    <name>B8E0H1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">Dtur_1342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ACK42616">
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    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1342"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1387"/>
    <dbReference type="eggNOG" id="ENOG5032RXZ">
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    </dbReference>
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    <dbReference type="OMA" id="IFGAQQY"/>
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    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="105" mass="12013" checksum="9FAD56FD3A82AE08" modified="2009-03-03" version="1">MRHKLIDLAKVIRTKNSGPFILTIDIIFKDSYVYKRLKEIDYFSKVWWAQVYGINLDDVISVIYFDPVSAVKANIKRRVPSGSPGDTDVYGAQQHAPLLEVEIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0H7</accession>
    <name>B8E0H7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase T-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1348</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="4">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583703.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353236.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1348"/>
    <dbReference type="EnsemblBacteria" id="ACK42622">
        <property type="protein sequence ID" value="ACK42622"/>
        <property type="gene ID" value="Dtur_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1348"/>
    <dbReference type="eggNOG" id="COG2195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021802_6_0_0"/>
    <dbReference type="InParanoid" id="B8E0H7"/>
    <dbReference type="OMA" id="NIVCDRV"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010162">
        <property type="entry name" value="PepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42994:SF2">
        <property type="entry name" value="PTHR42994:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01883">
        <property type="entry name" value="PepT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="5">
        <location>
            <begin position="179"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="365" mass="40474" checksum="72A0C51393C5F2C8" modified="2009-03-03" version="1">MLSKDRLINTFIDFVKISSLSLREKEFSSFLKNRLENLGLKVIEDNAGKTLGGNSGNLYAYLDGDGEPILISAHMDTVSPGENINPQIAGDYILSDGNTILGADDKAAISAIVEAIQTIKEKKERTKKIEFLFTIGEEIGLVGAKNIDPSLIKSKEGYVLDGEGDVGTLILRAPTHDRFYLNIYGKASHAGTSPEKGINAILLASDFLLNLSWGRIDDFTTANVGIIKGGRATNIVPDEVYLEGEFRSLDEDNLSSLWRRFEDNLIKLVKKGASYDLRKETLYRGFNIDEREKVVRRIVDVLNQMEKKINLTYTMGGSDANILNSYGIKTVNVGIGMENAHSKEERIKIENLYDTAVLIYNLIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0P7</accession>
    <name>B8E0P7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584141.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353681.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1795"/>
    <dbReference type="EnsemblBacteria" id="ACK43067">
        <property type="protein sequence ID" value="ACK43067"/>
        <property type="gene ID" value="Dtur_1795"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1795"/>
    <dbReference type="eggNOG" id="ENOG502ZI9J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2751316_0_0_0"/>
    <dbReference type="OMA" id="IEIYQGM"/>
    <dbReference type="OrthoDB" id="2099927at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK43067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="70" mass="8208" checksum="4DEE4FB464493A43" modified="2009-03-03" version="1">MKEKIKVFVNGEEIEIYQGMQVKHALISYDYDLYKKCVEGEYIVVNQDGFELGLEGTLNDNAKIYTKRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0P8</accession>
    <name>B8E0P8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Dtur_1796</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584142.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353682.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1796"/>
    <dbReference type="EnsemblBacteria" id="ACK43068">
        <property type="protein sequence ID" value="ACK43068"/>
        <property type="gene ID" value="Dtur_1796"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1796"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1848"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_0"/>
    <dbReference type="InParanoid" id="B8E0P8"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="3"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="354"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACK43068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="581" mass="65052" checksum="9157F7DA0BA15742" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0R0</accession>
    <name>B8E0R0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584154.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353694.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1809"/>
    <dbReference type="EnsemblBacteria" id="ACK43080">
        <property type="protein sequence ID" value="ACK43080"/>
        <property type="gene ID" value="Dtur_1809"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1809"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_0"/>
    <dbReference type="InParanoid" id="B8E0R0"/>
    <dbReference type="OMA" id="LGHINQP"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="396" mass="44089" checksum="87BA8D603B02D4DA" modified="2009-03-03" version="1">MVFIRTGRGGRASQQREVNKTIILNAFLRCRNISRTEIAKRFNLSKSTVTRLVNNLIDEGMIIEIEPSSEKKIGRKAIVLGLNPEYRNALAIKVGVTYTYLSKIDFAMNIKEIKSFLTPKNPQDFLDELEKATQMLFPEGLEKTHAVGIGIPGIVDNTFKNVVVAPNLNWKNLPLGDMIAERMRRAFSVEIPVKMDNEANMAVVAEGMLGTKIEYNDLNIVYVYVGEGIGTGLILDGKLYRGRYNTAGEFGHMTIMKDGIKCKCGNLGCWERYASLGGDIAEKAGFDLEKETAEIADEKALKKYVDELTVGLINIINGLNPDVIILGGPLIKKDTKDVWEFIRQEVKKIVEEKSITSDAGKVRIELTSFLDYPAELVGAGIWAFWDIFEGPVLSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0T2</accession>
    <name>B8E0T2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="6" type="ordered locus">Dtur_1395</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583747.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353283.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1395"/>
    <dbReference type="EnsemblBacteria" id="ACK42669">
        <property type="protein sequence ID" value="ACK42669"/>
        <property type="gene ID" value="Dtur_1395"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1395"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1442"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_0_1_0"/>
    <dbReference type="OMA" id="LWPGQSF"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="139"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="285" mass="33505" checksum="44CF1929F0E98A48" modified="2009-03-03" version="1">MYDYEWYVDLVAEDQLHCYKIEEVIVDLVSPYQRIQIIKNPTYGKCLIIDGKMQSTEKDEFIYHEVLIHPALILHPNPQKVLVIGAGEGATLRELLKYENVNITAIEIDPNMVDFAEKYLWEWHQGAFRNERVKLIFEDGWNFVRDTCEKFDIVVLDLPEPYPDTPAYRLYTEEFYKMIYHILNPSGIVVTQAETVQLGQEYKHFNIKKNFSAVFKSSHSYQTFIPSFDGSWGFLIGSRDELNPFKPVEVINELIGKKIKGELKYYDGETHNHLFHLPKYLRKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0U3</accession>
    <name>B8E0U3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF2179 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1406</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583758.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353294.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1406"/>
    <dbReference type="EnsemblBacteria" id="ACK42680">
        <property type="protein sequence ID" value="ACK42680"/>
        <property type="gene ID" value="Dtur_1406"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1406"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1453"/>
    <dbReference type="eggNOG" id="COG1284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063199_1_1_0"/>
    <dbReference type="InParanoid" id="B8E0U3"/>
    <dbReference type="OMA" id="AQIIHKY"/>
    <dbReference type="OrthoDB" id="1747063at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019264">
        <property type="entry name" value="DUF2179"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003740">
        <property type="entry name" value="YitT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10035">
        <property type="entry name" value="DUF2179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02588">
        <property type="entry name" value="YitT_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006483">
        <property type="entry name" value="Membrane_protein_YitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2179" evidence="8">
        <location>
            <begin position="216"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="278" mass="30156" checksum="46ABE3FFD367B990" modified="2009-03-03" version="1">MKKLINFLGISFGAFLIALSIDIFLVPNKLVGGGVSGIAIILYHIFKTPVGIMMLLLNIPIFLLGIKVLGIHFGIKTVYGTVILSLFIDFLTIFRLPQVRDPILATVYGGILGGIGLGIVFKYGGSTGGTDILAQVLSHFTGLNLGQALLIIDGMIVLSAGFIFDFVLALYALLVILIQGYAIDLVQQGLSYTKAALVFSDKPREIGERILRDLGRGVTIFYGKGMYTGKDREILYCVVSQSEVAKLKEIIHNCDPKAFVVISPAHEVLGEGFKSFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0U9</accession>
    <name>B8E0U9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DZR_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583764.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353300.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1412"/>
    <dbReference type="EnsemblBacteria" id="ACK42686">
        <property type="protein sequence ID" value="ACK42686"/>
        <property type="gene ID" value="Dtur_1412"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1412"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1459"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_1_1_0"/>
    <dbReference type="InParanoid" id="B8E0U9"/>
    <dbReference type="OMA" id="YSEGFVC"/>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044005">
        <property type="entry name" value="DZR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18912">
        <property type="entry name" value="DZR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DZR_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="231" mass="27343" checksum="0F88077CF45FC64D" modified="2009-03-03" version="1">MISFFENFLLDVLFPKKCVFCGRYSEGFVCKNCLKKLKFPEYYCLSCGQPLTVDLQICYNCNKEERKWDGYEFVAYYEDGWKDIISLFKFKNKPYIADFFSQIGSKKILRKKWKIDYITYVPLSYKTLKERGYNQSEYLAYFLSKSLKVAYGPLLYLKKNIKPQKTLNLKEREENMMNAFGVIENREINGNILLVDDVYTTGTTLKECTRTLKKSFNLDKVYIFTAVRVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0W2</accession>
    <name>B8E0W2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583777.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353313.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1425"/>
    <dbReference type="EnsemblBacteria" id="ACK42699">
        <property type="protein sequence ID" value="ACK42699"/>
        <property type="gene ID" value="Dtur_1425"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1425"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1472"/>
    <dbReference type="eggNOG" id="COG2236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0W2"/>
    <dbReference type="OMA" id="TYNDVHN"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="8"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="195" mass="22425" checksum="AC85C47C2186B673" modified="2009-03-03" version="1">MEFIAPSWEEIYNLCLDLSDRIKQQKYEPEIIVGIARGGWIPARILSDLLGNSYTANLKIDFYRGVGETKDRPVITQTISTIVEGRKVLITDDVADSGKSLKVAREHLEQCGASQVKIATIYYKPWSIVKPDFYISETEAWIVFPWERKEFVYKMYESLKSKGLNSKDVLRELLKTGLPEDLLKRFLKDITGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Z8</accession>
    <name>B8E0Z8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="10">AdoMetDC</shortName>
            <shortName evidence="10">SAMDC</shortName>
            <ecNumber evidence="10">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="primary">speH</name>
        <name evidence="11" type="ordered locus">Dtur_1461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583813.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353349.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1461"/>
    <dbReference type="EnsemblBacteria" id="ACK42735">
        <property type="protein sequence ID" value="ACK42735"/>
        <property type="gene ID" value="Dtur_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1461"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1510"/>
    <dbReference type="eggNOG" id="COG1586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_3_0"/>
    <dbReference type="InParanoid" id="B8E0Z8"/>
    <dbReference type="OMA" id="HTWPEKG"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042286">
        <property type="entry name" value="AdoMetDC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042284">
        <property type="entry name" value="AdoMetDC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 10" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023572285" description="S-adenosylmethionine decarboxylase beta chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023572283" description="S-adenosylmethionine decarboxylase alpha chain" evidence="10">
        <location>
            <begin position="67"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="10">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="10">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="10">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="10">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="10">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="142" mass="16011" checksum="E196D2563767BEB9" modified="2009-03-03" version="1">MKITGKSLGRHILAEMYNCNREILNDVEKIKEIMVRAAIEAGAEVVEVVFHKFSPYGVSGVVVISESHLAIHTWPEYGFAAADLFTCGDHVNPWKAFEYLNNYLQAEQFITFEAKRGILPIEAGNFTYKPESVKEEEKETVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E108</accession>
    <name>B8E108_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrimidine-nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1471</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583823.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353359.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1471"/>
    <dbReference type="EnsemblBacteria" id="ACK42745">
        <property type="protein sequence ID" value="ACK42745"/>
        <property type="gene ID" value="Dtur_1471"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1471"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1520"/>
    <dbReference type="eggNOG" id="COG0213">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025040_0_1_0"/>
    <dbReference type="InParanoid" id="B8E108"/>
    <dbReference type="OMA" id="DVWRRMI"/>
    <dbReference type="OrthoDB" id="1724909at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="345"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="434" mass="47499" checksum="999B92CC321686FE" modified="2009-03-03" version="1">MRMIDIIIKKRNGEALSEEEISFVVDGYVKGDIPDYQMSALLMAIYFRGMNIEETITLTKKMAYSGKVLDLSSIPGIKVDKHSTGGVGDKTTLIFAPLIASMGYPVAKMSGRSLGHTGGTIDKLESIPGFKTSMKDEEFIKQVKEIGIAIVGQTEDLVPADKKIYALRDVTGTVDSIPLIASSVMSKKIASGSDVIILDVKVGRGAFIKDINSAKELARIMVGIGKGFGRKIVAVLSQMDQPLGFAIGNSLEVMEAIETLKGRGPKDLNELIVTLATETLRLININYKNEDIRAKVMEQLSNGKALAKFKEMIKTQGGDVKIVDDYSPLLSAKIQKEIYSLEGGYVEDIDAYKVALSVMALGAGREKKEDKIDLSVGIRLYKKIGDKIEKNEPIVTFYANDVEKLKRAQEIFREAIKIGNKKKDPLPIVLDVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E162</accession>
    <name>B8E162_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Patatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583274.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352804.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0909"/>
    <dbReference type="EnsemblBacteria" id="ACK42190">
        <property type="protein sequence ID" value="ACK42190"/>
        <property type="gene ID" value="Dtur_0909"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0909"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047251_2_1_0"/>
    <dbReference type="InParanoid" id="B8E162"/>
    <dbReference type="OMA" id="CSMPGLL"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="39"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="310" mass="34953" checksum="58F79097EBFF39C2" modified="2009-03-03" version="1">MRGVKIGLALGSGGAKGLSHIGVLKVLEEYNIEISFITGSSIGALIGGLYAKGYSSKELENLANSIAENKEQFYKLFDFSKSLQGIIKGDKILEYLDNLLEGTTFDKLKKPFIPIAVDLIMGEKVYVQEGKVSEGIRGSISIPVIFQPFPWKDKLLIDGGVLSPLPVKDLKKLYKPDIVIAVSLHKRSKWAPKNNISIDIPYKPNTITEKITYTLSQTSIFREFQKRLNPLLNPSLFDVLMQTIDIMNYELEEDNKKEADIVIIPEVQNYGTFDFDKAKELIEKGESATKEKIQEILNLIKRKKKKFIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E185</accession>
    <name>B8E185_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Extracellular ligand-binding receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583297.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352827.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0932"/>
    <dbReference type="EnsemblBacteria" id="ACK42213">
        <property type="protein sequence ID" value="ACK42213"/>
        <property type="gene ID" value="Dtur_0932"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0932"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.969"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_6_1_0"/>
    <dbReference type="InParanoid" id="B8E185"/>
    <dbReference type="OMA" id="YGVGFEQ"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002871044" evidence="3">
        <location>
            <begin position="25"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="27"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="376" mass="40268" checksum="54BC64A394A4A6F4" modified="2009-03-03" version="1">MKRFVKIFVIALLVLALFVLPLQAAGTIKIGGIFPITGPIATFGISCANGAKMAVEEANARGGVLGSKIELIIEDDQYKLEEAANAAKKLIERDKVVAIVGGVTSSEALTIGPIAQSAKVVLVTGTATNPKVTQVGDFIFRVCFLDDFQGEVMANFAYKNLKAKTAAVLTAVTSDYSKGLADSFKKKYVALGGKIVADESYSEGDTDFRAQLTKIKASKPDFVFVPGYYSDVAPILNQARELGITVPFGGGDGWDSPELLKQAAKAAEGCFYTNHFTPDAKDLLVQTFVKNYTKKYGMAPDALAALKYDAMKFLLEGIKKAGTTDPVKIKEALASMKTFRGVTGSMTFDANRNAIKSAFILQIKGGKVVYYTTVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E188</accession>
    <name>B8E188_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583300.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352830.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0935"/>
    <dbReference type="EnsemblBacteria" id="ACK42216">
        <property type="protein sequence ID" value="ACK42216"/>
        <property type="gene ID" value="Dtur_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0935"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.972"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="InParanoid" id="B8E188"/>
    <dbReference type="OMA" id="EHDMRFI"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015188">
        <property type="term" value="F:L-isoleucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015192">
        <property type="term" value="F:L-phenylalanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005304">
        <property type="term" value="F:L-valine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042941">
        <property type="term" value="P:D-alanine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015808">
        <property type="term" value="P:L-alanine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903806">
        <property type="term" value="P:L-isoleucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903805">
        <property type="term" value="P:L-valine import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098713">
        <property type="term" value="P:leucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="259" mass="29279" checksum="2B26BF1DF5076C73" modified="2009-03-03" version="1">MKILEVKNLSCAFGGLMAVSDLSFELHKNEILGIIGPNGAGKTTVFNLITGFYLPLKGEIIFNGKNIVGLKPYQITRLGIARTFQNPRLFKKLSVMENVMIAMHKVYNAHMLDAILQNKRYSVEESLQKERAEEILEFFGLYRRKNDTAENLPYGEQRKLEIARALATNPTLLLLDEPAAGMNLNESLELVDLIATIRDKFDLTVLLIEHHMEVVMNICKRIIVLDFGMKIAEGNPEKVRNDPRVIEAYLGKEVKGVIH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1B4</accession>
    <name>TSAD_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="1">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsaD</name>
        <name type="synonym">gcp</name>
        <name type="ordered locus">Dtur_0962</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583326.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352856.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1B4"/>
    <dbReference type="SMR" id="B8E1B4"/>
    <dbReference type="STRING" id="515635.Dtur_0962"/>
    <dbReference type="EnsemblBacteria" id="ACK42242">
        <property type="protein sequence ID" value="ACK42242"/>
        <property type="gene ID" value="Dtur_0962"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0962"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.999"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_0"/>
    <dbReference type="InParanoid" id="B8E1B4"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000145973" description="tRNA N6-adenosine threonylcarbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <sequence length="334" mass="36606" checksum="0FBB61379DC0F11C" modified="2009-03-03" version="1">MITIGIETSCDETSVSLLEDGNKILSNLVSSQVEIHKTFGGVVPEVASRIHVEVLNRLIELALEKAKKEFTDIDLIAVTQGPGLIGALWIGIMAAKTLSLALNKPLIGVNHLEGHIFANFLGEDPPTFPFIALIVSGGHTEYILVEDIGVYKILGQTLDDAAGEAFDKVARILGLNYPGGPEIDKISKMGKPIFNFPKIKCDRELDISFSGIKTAVLYLVRDLKKEGKEIPVADIAASFQERVVEELLERAFLALNKFNIKTLVVSGGVASNSYLQRRFKEESRKEGIKLYIPPPYLCTDNGAMIACAGYHLYQKGYKSDLYLSANPDLLLGER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1C8</accession>
    <name>RS12_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsL</name>
        <name type="ordered locus">Dtur_0976</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583340.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352870.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1C8"/>
    <dbReference type="SMR" id="B8E1C8"/>
    <dbReference type="STRING" id="515635.Dtur_0976"/>
    <dbReference type="EnsemblBacteria" id="ACK42256">
        <property type="protein sequence ID" value="ACK42256"/>
        <property type="gene ID" value="Dtur_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0976"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1013"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1C8"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000194158" description="30S ribosomal protein S12">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-methylthioaspartic acid" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="128" mass="14181" checksum="48647AA45CA1E630" modified="2009-03-03" version="1">MPTINQLIRKGREPKERKSKSPALMGNPQKRGVCIRVTTMTPKKPNSALRKVARVRLTNGIEVWAYIPGIGHNLQEHSVVLVRGGRVKDLPGVRYHIIRGALDAAGVEGRRQGRSKYGAKRPKEGGKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1C9</accession>
    <name>RS7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsG</name>
        <name type="ordered locus">Dtur_0977</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583341.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352871.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1C9"/>
    <dbReference type="SMR" id="B8E1C9"/>
    <dbReference type="STRING" id="515635.Dtur_0977"/>
    <dbReference type="EnsemblBacteria" id="ACK42257">
        <property type="protein sequence ID" value="ACK42257"/>
        <property type="gene ID" value="Dtur_0977"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0977"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1014"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_0"/>
    <dbReference type="InParanoid" id="B8E1C9"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000125935" description="30S ribosomal protein S7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17789" checksum="79ED63600A679E44" modified="2009-03-03" version="1">MPRRGPVTPREIPPDPVYNSVLVQKLINKVMLDGKKSIAEKIVYGAMDIIREKTKQDPLTVLEKAVQNVTPLLEVRPRRVGGATYQVPIEVPPRRGLSLALRWIVRAARERKGMPMKERLALEILDAFNNTGGAIKKRDEMHRMAEANKAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1D5</accession>
    <name>B8E1D5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ordered locus">Dtur_0983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583347.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352877.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0983"/>
    <dbReference type="EnsemblBacteria" id="ACK42263">
        <property type="protein sequence ID" value="ACK42263"/>
        <property type="gene ID" value="Dtur_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0983"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1020"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_2_0"/>
    <dbReference type="InParanoid" id="B8E1D5"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="95" mass="10719" checksum="146F5DB6EA4097D2" modified="2009-03-03" version="1">MRDPYTIILKPILTEKSLNLAKQNKYVFEVDRNANKIEIGKAVEEIFKVKVKSVAVINEKPKKRRLGISQGFTSTKKKAIVTLEPGHKIELISGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1K4</accession>
    <name>B8E1K4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582614.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352143.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0200"/>
    <dbReference type="EnsemblBacteria" id="ACK41529">
        <property type="protein sequence ID" value="ACK41529"/>
        <property type="gene ID" value="Dtur_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0200"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038661_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1K4"/>
    <dbReference type="OMA" id="PMVVDMT"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="9"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="415" mass="45998" checksum="CCD2E63A2C2980A8" modified="2009-03-03" version="1">MNRGFNFFKIFLLGFGFLSISLLWSIYNTDIPIILQKTYKISSFAVGWVMNLDNILAIFLIPLIGVLSDRTLTKIGKRMPYIITSLPIGAILFSLIPWIPIFFGINTPSLILLVLIILLMNIAQAVGRGPVISLMPDLVAPEHRSPANGIINFMGGLGSLLAYFFVGRISVVNRPLGFAIAGIIQLISVLVIFLAIKETKDSIIMTKMEEETELSFKKLINIKDKNLIFLLLAIFFWFIGFNAVETFYSVYMALEKGIDPTLGESISKINLGILALTFMIFSIPSGFIAKKIGRKRTIMIGLLGMILAFIGLIIFESLFITRIIFILGGISWALININSLPMVLDLGNLKSQGTHTGFYYFSSQLASIVAPPFAGFLADLLKTRFVIFPLGGVFFTLSLLMLLQVQGGEPKKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1L3</accession>
    <name>B8E1L3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ParB-like partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0209</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582623.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352152.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0209"/>
    <dbReference type="EnsemblBacteria" id="ACK41538">
        <property type="protein sequence ID" value="ACK41538"/>
        <property type="gene ID" value="Dtur_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0209"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.218"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1L3"/>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045881">
        <property type="term" value="P:positive regulation of sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="3">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="272" mass="31500" checksum="EA3459318E106E83" modified="2009-03-03" version="1">MSSQKKGLGRGLEALIGEEEKLIEKIPIDKIVPNPNQPRETLNPETLQELVESIKQLGLLQPILVRPKGDYYEIVAGERRYHAAKTAGLKEIPVIIKEIDDQSAWDIALTENLQREDLNPIEKAKAFQYYIETFNVTQEELAQRLSISRSEVANFLRLLQLPPEIQEEVRRGNLTYGHARTLLGIEDPNMQKLLAQKIIREKLSVREIEDLVKKRKIRNEIEIPEIRSLEEKLEQYLGTRVKIQPKSPNKGKITIEYKSLEHLEEIIRKFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1M9</accession>
    <name>B8E1M9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582639.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352168.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0225"/>
    <dbReference type="EnsemblBacteria" id="ACK41554">
        <property type="protein sequence ID" value="ACK41554"/>
        <property type="gene ID" value="Dtur_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0225"/>
    <dbReference type="eggNOG" id="COG1547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036791_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1M9"/>
    <dbReference type="OMA" id="DTLFHIQ"/>
    <dbReference type="OrthoDB" id="233805at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="548" mass="66393" checksum="5AEA436D1B1951AD" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Q2</accession>
    <name>B8E1Q2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582662.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352191.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0251"/>
    <dbReference type="EnsemblBacteria" id="ACK41577">
        <property type="protein sequence ID" value="ACK41577"/>
        <property type="gene ID" value="Dtur_0251"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0251"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.264"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038034_13_1_0"/>
    <dbReference type="InParanoid" id="B8E1Q2"/>
    <dbReference type="OMA" id="WLMPEYA"/>
    <dbReference type="OrthoDB" id="1473468at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="1">
        <location>
            <begin position="51"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="369" mass="41775" checksum="7F4614338B99FF75" modified="2009-03-03" version="1">MNINKYIFKFALLIPLLLIFYSSLSFSQTKNTISIIDLAGRKVEISQPVKRVVAIGPGALRIVSYVDQFSRIVGVENIDKRYTIGRTYNMAFFDIIEKLPIIGQGGPDTSPDPEKLIAVNPDVIFVIQLLDKGGADKLYEKTKIPVVVLNYGTLGTFDEDLFKSLEIVGKVLNKEARASAIITYIKNIRNAFSLKTRYIADKNKPSVYVGALGFKGARGIESTQGYFPIFTPLYIKNVADSLGKKGSVFIEKEKLLIWDPDIIFLDLGNLNLVKDDFSKNPDFYKALRAYKNKNIYGIYPYNNYNTNIDTALVDMFWVAKVVYPDKFKDIIIGNKAQEIYTFFFGERGKNIYSELAKSYGELKRVNLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Q3</accession>
    <name>B8E1Q3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0252</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582663.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352192.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0252"/>
    <dbReference type="EnsemblBacteria" id="ACK41578">
        <property type="protein sequence ID" value="ACK41578"/>
        <property type="gene ID" value="Dtur_0252"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0252"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908305_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1Q3"/>
    <dbReference type="OMA" id="SPTQAEY"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="195"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="306" mass="35034" checksum="985B3DD288A02B89" modified="2009-03-03" version="1">MVPENNRDILIVEDSPTQAEYLRKILRDYNFSSFVALSGEEAIEILKSKTPKLIISDILMPGIDGFELCKIVKSSEKWKDIIVLLLTTLSDPKDIIKALDVDADAFIIKPFNKKYLISTVQFLISHSELKKLGYTESNLEINIMGKKYTLRSTQIQILNLLLFSYEKTIGDMEEIRKLKQEIKKLNEKLREIYEKDKEYDFLIEGIPIPILVIKDIRGEIIGANSSALSFFNMKKEKIIGKNIFEILHLSPLHITQLRETLTPSKDKKTVKIKATLPSGESAELRIITTPIFYKEVPAFQVSILKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1R7</accession>
    <name>B8E1R7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0396"/>
    <dbReference type="EnsemblBacteria" id="ACK41700">
        <property type="protein sequence ID" value="ACK41700"/>
        <property type="gene ID" value="Dtur_0396"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0396"/>
    <dbReference type="HOGENOM" id="CLU_2081047_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="117" mass="12819" checksum="DAB8499BEC11D698" modified="2009-03-03" version="1">MVIVKKFRLIDVYAKFVVSDGIRTVHTRIPSSGDWGMDEGDIRDNINVVIFDTPRIGNYLSINVRVYDADAGDDDLIGVGSLYLTSSQNWGKGRVLSIICNGGGPGEGEMEVVVEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1S3</accession>
    <name>B8E1S3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582791.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352320.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0402"/>
    <dbReference type="EnsemblBacteria" id="ACK41706">
        <property type="protein sequence ID" value="ACK41706"/>
        <property type="gene ID" value="Dtur_0402"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0402"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.423"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023504_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1S3"/>
    <dbReference type="OMA" id="QSGHNSE"/>
    <dbReference type="OrthoDB" id="393364at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024749">
        <property type="entry name" value="Collagen-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025277">
        <property type="entry name" value="DUF4038"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12904">
        <property type="entry name" value="Collagen_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13204">
        <property type="entry name" value="DUF4038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4038" evidence="2">
        <location>
            <begin position="9"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Collagen_bind_2" evidence="1">
        <location>
            <begin position="362"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="442" mass="50444" checksum="60A8C913E3E2A501" modified="2009-03-03" version="1">MSLPSLKISQNGRFLITEDGNPFFYLGDTAWELFHRLTLEEAELYLTVRSSQGFNVVQAVILAELDGLHTPNANGHVPLIGDDPARPNEYYFRHVDSVIKLAEEKGIYMGILPTWGDKVHSGLWGVGPVIFDKSNAYIYGKFLGERYRDFTNIIWILGGDRPGEGYEEVWTSMARGIYDGLGRKPIITYHPSGGQSSSQWFHNAEWLSFNMCQSGHCLIDTPNWDMIRSDYNKTPIKPVIDGEPNYEGHPIDPYLRKWKPEYGRFTDYEVRKQAYRAVFSGACGHTYGHHSVWQMYDERYKPMTFANVYWYEAIYAPGAKQMIHLKNLLLSLPYFTRIPAQDMLTEITPPPPPKDIDDRLNNRRASYPVATCDKEGSYALIYFPLANQTLNIDTSSLSGHIIKASWFDPRSGERHYIGEFAKGTLRFTSPLGGPDWILVLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1V2</accession>
    <name>B8E1V2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n H(+) + n methanol</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582820.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352349.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0433"/>
    <dbReference type="EnsemblBacteria" id="ACK41735">
        <property type="protein sequence ID" value="ACK41735"/>
        <property type="gene ID" value="Dtur_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0433"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.457"/>
    <dbReference type="eggNOG" id="COG4677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012243_3_1_0"/>
    <dbReference type="InParanoid" id="B8E1V2"/>
    <dbReference type="OMA" id="GFLFTNC"/>
    <dbReference type="OrthoDB" id="1095798at2"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045330">
        <property type="term" value="F:aspartyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase" evidence="4">
        <location>
            <begin position="139"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="457" mass="51091" checksum="E39E4B8ADD41BD06" modified="2009-03-03" version="1">MEIKNIILLLTLILLLIITGCSAKESNLVFNVTVLNPPSSVVIDNPYTLNLISTQDAFVTVYLNDNIVFENYPIKANSTQSINISFSKSRGNNIRVEVRNRNQEKYEYAYENVLYLPKVDIVVDKNYTGEDGTEINGRKYFKSVLKAMVYITLNQSAYSGRRVYVFIKSGDYYEKVNIMSPNISLIGEDVNTTRIYYDLAAGSPGAGGTSGSASVTIAGSATGFTAENITFENAFDEIANANISSKQAVAVLSQSDKAVFKNCRFIGNQDTLYVRGGIHYFVDCYIEGDVDFIFGDGRAVFEKCVIFSVDRAGITPKGYVTAASTKIGNLGFLFTNCELKTNINEEGSVYLGRPWHPSSDPYSVNSNVVLRNCYMDKHIHPDGWTAMSSKDPNTGETIWFYPDTERFYEYENYGPGAIINDKRRQLTGDDVNYYTKENYLGGWDVESFIKNLYEAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1W2</accession>
    <name>B8E1W2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582830.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352359.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0443"/>
    <dbReference type="EnsemblBacteria" id="ACK41745">
        <property type="protein sequence ID" value="ACK41745"/>
        <property type="gene ID" value="Dtur_0443"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0443"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.468"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_7_1_0"/>
    <dbReference type="InParanoid" id="B8E1W2"/>
    <dbReference type="OMA" id="EPDRLHR"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="69"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="254" mass="28788" checksum="FBA5059C4751B435" modified="2009-03-03" version="1">MKSKVGISSANQTLEILEYIVLSGREVSLKEIAEEIGLHVSTVHRYLSSLLEKGYVRKTQNGLYKPGFRILELSSYILQGFDLREIARPFLIELMENTKQTVHLTIRDAYEGVYIDKVEGPGTLPMMSRIGMRMPLYSTSFGKVLLAYSPESFINEYLRKVPLIPRTENTITDPEKLKEELLKVKKQGYAFDNEENERGIKCIGAPIFDYSGNVVAAVSISGYYKDFEGENREKLLKELLSACDRISSVLRSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1X6</accession>
    <name>B8E1X6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DGC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582844.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352373.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0458"/>
    <dbReference type="EnsemblBacteria" id="ACK41759">
        <property type="protein sequence ID" value="ACK41759"/>
        <property type="gene ID" value="Dtur_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0458"/>
    <dbReference type="eggNOG" id="COG4273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143943_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1X6"/>
    <dbReference type="OMA" id="RMCCLSA"/>
    <dbReference type="OrthoDB" id="1683508at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014958">
        <property type="entry name" value="DGC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08859">
        <property type="entry name" value="DGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037181">
        <property type="entry name" value="DGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="134" mass="14378" checksum="4AE7824250146958" modified="2009-03-03" version="1">MSKGGWQILPHCASEAENLDIIVACDGASSVGQVGNEVAIKLTKENEGARMCCLSAIAAGSKVHINIAKNARKLIVINGCQLECASKVIRNQGIEPTYEITIAKEGIEKAPTLDFDDEDVERIAEKIAKEVLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8E228</accession>
    <name>B8E228_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="9">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">thrS</name>
        <name evidence="11" type="ordered locus">Dtur_1025</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583388.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352919.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1025"/>
    <dbReference type="EnsemblBacteria" id="ACK42305">
        <property type="protein sequence ID" value="ACK42305"/>
        <property type="gene ID" value="Dtur_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1025"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1062"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_0"/>
    <dbReference type="InParanoid" id="B8E228"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
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        <property type="match status" value="1"/>
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            <end position="530"/>
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        <location>
            <position position="330"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <location>
            <position position="381"/>
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        <ligand>
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        <location>
            <position position="507"/>
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        <ligand>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="638" mass="74706" checksum="4045A34AE65CDA1B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E236</accession>
    <name>B8E236_DICTD</name>
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        <submittedName>
            <fullName evidence="3">Fimbrial assembly membrane protein, putative</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">Dtur_1033</name>
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
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    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352927.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1033"/>
    <dbReference type="EnsemblBacteria" id="ACK42313">
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        <property type="gene ID" value="Dtur_1033"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PilO"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="193" mass="22357" checksum="D1F2C7FFB94E8228" modified="2009-03-03" version="1">MKISINKWVIIGIIIFIIAIGFYFVFYKALENEKVALTESIETNRQMLLKYQLSYKKSLEEWEKFKDSLQRFAEIQQKLPTKEDLPTLLAFIESIAKNSKLSINSFKPLPPATKQETTTQQQGKQPQQEQKSTYEERSYSLDLQGNYGGFLLFLAKLKTAPRLILMKDLKIDPVDVSAKELKFSFILSTFITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E238</accession>
    <name>B8E238_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type II and III secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1035</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583398.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352929.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1035"/>
    <dbReference type="EnsemblBacteria" id="ACK42315">
        <property type="protein sequence ID" value="ACK42315"/>
        <property type="gene ID" value="Dtur_1035"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1035"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1072"/>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253040_0_0_0"/>
    <dbReference type="InParanoid" id="B8E238"/>
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    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004845">
        <property type="entry name" value="T2SS_GspD_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00875">
        <property type="entry name" value="T2SP_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="STN" evidence="6">
        <location>
            <begin position="336"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="6">
        <location>
            <begin position="500"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="6">
        <location>
            <begin position="598"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="6">
        <location>
            <begin position="760"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="6">
        <location>
            <begin position="922"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="6">
        <location>
            <begin position="1084"/>
            <end position="1132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1421" mass="157810" checksum="1217F3757ADF0A6F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E250</accession>
    <name>B8E250_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583410.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352941.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1047"/>
    <dbReference type="EnsemblBacteria" id="ACK42327">
        <property type="protein sequence ID" value="ACK42327"/>
        <property type="gene ID" value="Dtur_1047"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1047"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1084"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_0"/>
    <dbReference type="InParanoid" id="B8E250"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="21"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="322"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="580" mass="66350" checksum="BCE26AAD11A066F1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E260</accession>
    <name>B8E260_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="3">2.5.1.54</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1057</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.54" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583420.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352951.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1057"/>
    <dbReference type="EnsemblBacteria" id="ACK42337">
        <property type="protein sequence ID" value="ACK42337"/>
        <property type="gene ID" value="Dtur_1057"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1057"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1094"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_0"/>
    <dbReference type="InParanoid" id="B8E260"/>
    <dbReference type="OMA" id="YRNIPEW"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="90"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="341" mass="37896" checksum="7B73113E2AD0CAE3" modified="2009-03-03" version="1">MIIVLKSGATEEDIQKVIDKLKEYNYGAHISRGENKVVIGAIGEKRMEEKILIMEQISSFPFVEQVIPILTPYKLVTKEFNPQGTRIKVNQVEIGNEEIVVMAGPCAVESREQLREIAGFVKEVGAKVLRGGVFKPRTSPYSFQGLGIEGLKLLYEVKNEFDIPVITEVMDPRDLDIVAEYVDIIQIGARNMQNFTLLKEVGKLRKPVLLKRGLSATLEEFLFAAEYILLGGNSEVILCERGIRTFSDFSRNTLDLSIIPALKEKTHLPVFVDPSHGTGNYRYVPSMAKAAIAAGADGLIIEVHPHPEKALSDGPQSLTFSDFRRLMNELKAIASAVGRRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2C2</accession>
    <name>HIS1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName>ATP phosphoribosyltransferase</fullName>
            <shortName>ATP-PRT</shortName>
            <shortName>ATP-PRTase</shortName>
            <ecNumber>2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">hisG</name>
        <name type="ordered locus">Dtur_1120</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text>Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>Lacks the C-terminal regulatory region which is replaced by HisZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583482.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353013.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2C2"/>
    <dbReference type="SMR" id="B8E2C2"/>
    <dbReference type="STRING" id="515635.Dtur_1120"/>
    <dbReference type="EnsemblBacteria" id="ACK42399">
        <property type="protein sequence ID" value="ACK42399"/>
        <property type="gene ID" value="Dtur_1120"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1120"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1157"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_2_0_0"/>
    <dbReference type="InParanoid" id="B8E2C2"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="OrthoDB" id="1419568at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000135280" description="ATP phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="207" mass="23797" checksum="C015A3D540E61D9E" modified="2009-03-03" version="1">MIRVAIPTGRMLEQALDFLRNFDDRLLDEEKGRKLRIHGERFEVFLAKPWDLPLYVEERVVDLGIIGRDVIWEQEKNVVNLISLPFGYCKMVIAGYPYVSLKGNGKEIRIATKYENITKKLLENRWGKIKIIKLNGSVELGPILNISDLIVDIVETGKTLRDNGLEVKEVLFESSACLISNVVSFAYLRKEILSFVKEVRKLNDKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2C4</accession>
    <name>B8E2C4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hisC</name>
        <name evidence="5" type="ordered locus">Dtur_1122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353015.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1122"/>
    <dbReference type="EnsemblBacteria" id="ACK42401">
        <property type="protein sequence ID" value="ACK42401"/>
        <property type="gene ID" value="Dtur_1122"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1122"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1159"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_1_0"/>
    <dbReference type="InParanoid" id="B8E2C4"/>
    <dbReference type="OMA" id="FDGYPIL"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3 5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="4">
        <location>
            <begin position="23"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="350" mass="40962" checksum="37B4A4C3CDAF076E" modified="2009-03-03" version="1">MNIEKLLKSNYVGYKANVPDLPIKLSRNENPYDIPKEIKEEILNELLNTPWNRYPDGQSLRLRNKLAEFLNLSAENILVGTGSGELIQLVFNGFLEEGDRVILPVPTFPLYEKLLQQRKIEIIKVFLNKEDFSLNFDLLKNYFQYNPKILVITNPNNPTGNFLLKKEDFEKIKDFPGIILIDEAYYEFSGLTFLSHTETFPNVIILRTFSKAFSGAGIRLGYLISNSKIVGYLNNFKLPYNVNVFTQIAGERLIEKWDLLKNRIEIIKRERDRVFEEMQRLKDIKVYPSETNFILFRSKKIYEILKKCEEEGIALRDFSKEPLLENCLRVSIGDRRENDIFIRVLKEVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2C9</accession>
    <name>B8E2C9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histidine biosynthesis bifunctional protein HisIE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <shortName evidence="15">PRA-CH</shortName>
                <ecNumber evidence="15">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Phosphoribosyl-ATP pyrophosphatase</fullName>
                <shortName evidence="15">PRA-PH</shortName>
                <ecNumber evidence="15">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">hisI</name>
        <name evidence="15" type="synonym">hisIE</name>
        <name evidence="17" type="ordered locus">Dtur_1127</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 15">In the C-terminal section; belongs to the PRA-PH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 15">In the N-terminal section; belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="15"/>
    <dbReference type="EC" id="3.6.1.31" evidence="15"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583489.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353020.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1127"/>
    <dbReference type="EnsemblBacteria" id="ACK42406">
        <property type="protein sequence ID" value="ACK42406"/>
        <property type="gene ID" value="Dtur_1127"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1127"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1164"/>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_3_1_0"/>
    <dbReference type="InParanoid" id="B8E2C9"/>
    <dbReference type="OMA" id="ERSCFHQ"/>
    <dbReference type="OrthoDB" id="1842189at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01019">
        <property type="entry name" value="HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023019">
        <property type="entry name" value="His_synth_HisIE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRA-CH" evidence="16">
        <location>
            <begin position="37"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-AMP cyclohydrolase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoribosyl-ATP pyrophosphohydrolase" evidence="15">
        <location>
            <begin position="120"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACK42406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="208" mass="24170" checksum="EB489FE5AEC31384" modified="2009-03-03" version="1">MGEIRLEINELIEDLKFDEKGLIPVIVQDYKTGKVLMHAYMNEEALKKTIETGEAWYYSRSRRTLWHKGETSGNYQKVVDIAVDCDKDTLLLLVEQIGVACHTGNFSCFYRSLKGGASFIFHLENLLRERKKTLPENSYSAKLFREGKEKILQKLGEESIETIIAGMNGKKDEFIYEASDLLFHFLVSLIEENVEFREIIEELIRRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2E1</accession>
    <name>B8E2E1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">Dtur_1511</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583862.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353399.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1511"/>
    <dbReference type="EnsemblBacteria" id="ACK42785">
        <property type="protein sequence ID" value="ACK42785"/>
        <property type="gene ID" value="Dtur_1511"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1511"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1560"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_3_0"/>
    <dbReference type="InParanoid" id="B8E2E1"/>
    <dbReference type="OMA" id="NKKAFCY"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="554"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="724"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1059" mass="123662" checksum="4347F2D1C7AEAF3D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2E5</accession>
    <name>B8E2E5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Aminomethyltransferase</fullName>
            <ecNumber evidence="3 7">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gcvT</name>
        <name evidence="10" type="ordered locus">Dtur_1515</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3 7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583865.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353403.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1515"/>
    <dbReference type="EnsemblBacteria" id="ACK42789">
        <property type="protein sequence ID" value="ACK42789"/>
        <property type="gene ID" value="Dtur_1515"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1515"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1564"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_0"/>
    <dbReference type="InParanoid" id="B8E2E5"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00259">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022903">
        <property type="entry name" value="GCS_T_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="8">
        <location>
            <begin position="7"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="9">
        <location>
            <begin position="274"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="356" mass="41193" checksum="BEEB70CE9F8B1ED1" modified="2009-03-03" version="1">MAKRLFLEDEHLKYGAKFFEFAGWWMPLEYSGTINEHLTVRKHVGIFDISHMGRILLKGQKVKNFVQYVTTNDVNNLYPGKAQYSLILNYDGTIKDDIIVYEISEEEFLLVVNAINTQKILDWLNLNNKFEVNILDLTNTTTLLAIQGPDSEKVLEEYFNLNLSNIKYYHFKKNHMIISRTGYTGEDGFEIVSDPEIGRKIFRDLVEKKKATPCGLGARNTLRIEMGYALYGHEIDENTTPWEANLGWVVKLNKGDFIGKDSLVERKTKKEKILKGFVMLENGIPRDGYEVYLDKERIGYITSGTFSPMLKMGIGMLYTTKDINHEILIKIREKFYKAKIEKPPFVKNTSIKKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2H1</accession>
    <name>B8E2H1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583890.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353429.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1541"/>
    <dbReference type="EnsemblBacteria" id="ACK42815">
        <property type="protein sequence ID" value="ACK42815"/>
        <property type="gene ID" value="Dtur_1541"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1541"/>
    <dbReference type="eggNOG" id="COG1811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091659_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2H1"/>
    <dbReference type="OMA" id="IYCVGAM"/>
    <dbReference type="OrthoDB" id="1815957at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007563">
        <property type="entry name" value="DUF554"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36111">
        <property type="entry name" value="PTHR36111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04474">
        <property type="entry name" value="DUF554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="224" mass="23933" checksum="D9C3C0B6A5FB13DE" modified="2009-03-03" version="1">MGTIVNSITVIIGGLMGTIFKKRIPEGLQKLLMDALGLICIPLGMEMAIKGEKFLALVFSIVVGAIIGELLGIHAWLENLSLKIEKKFAKEQNTFAKGFLTATLLYCIGPMTIMGSLQDGLGQTPQILYTKALLDGTASIALASALGVGVIFSSISVLIVQGSITLFARFISPFFTTLVVQEMTAVGGVLILGIALNLLNIKQIKVANLLPALFLIPFFIHIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2H3</accession>
    <name>B8E2H3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ordered locus">Dtur_1543</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583892.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353431.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1543"/>
    <dbReference type="MEROPS" id="C26.957"/>
    <dbReference type="EnsemblBacteria" id="ACK42817">
        <property type="protein sequence ID" value="ACK42817"/>
        <property type="gene ID" value="Dtur_1543"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1543"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1592"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_0"/>
    <dbReference type="InParanoid" id="B8E2H3"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="191"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="218"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="507" mass="57700" checksum="B5BFEB34DEB8C6FD" modified="2009-03-03" version="1">MIAVVDFGSQYTQLIARRFREIGVYSEIYSPNVKYSFLKEKEVKGIVLSGGPNSVYDSDLEIDYEIFKGDIPILGICFGFQFMAKFLGGEVRKGEKGEFGLTEIKIVRDSLLFEGLEKKEKVWMSHYDVVTKLPEDFVDIAISENGFLAAAQSLKKPFFAVQFHPEVSHTEKGRLIIENFAFKICKAEKNWNLDRFVEEKIEEIREQVGENKVLLAVSGGVDSTTLAVLLQRAIGDKLTAIFVDHGLLRIGEKEEVSRFLKDLGVNLVVIDARERFLEKLRGVIDPEEKRRVIGHEFVGVFKEEARKRGPFKFLAQGTLYPDVIESAASNTGMAAKIKTHHNVGGLPEELGFELIEPFRYLFKDEVRKIAEILGIPKDIIRRQPFPGPGLAVRILGEVTEDKLELLRRADRILMEEIKKWDKYDEIWQSFAVLLPIKTVGVKGDFRSYEYVIAIRIVKSEDGMTANFVEVPYDILGKIARRITNEIIGINRVVYDLTDKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2L7</accession>
    <name>B8E2L7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583936.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353475.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1588"/>
    <dbReference type="EnsemblBacteria" id="ACK42861">
        <property type="protein sequence ID" value="ACK42861"/>
        <property type="gene ID" value="Dtur_1588"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1588"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1638"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2L7"/>
    <dbReference type="OMA" id="LQRYYMR"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="88"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="320" mass="36837" checksum="BF5D00EBC1BDCEE1" modified="2009-03-03" version="1">MSIYRKYGKEELILIFKNKVYKWFITLLKIMLFIGLSYVLLRPVLFMLSTALKSREDLIDPTVVWIPKHPTLENFKKAFESLNYLNAFKNSLIISILPAIFNVISCSMIGYGLARFKFKERELIFALILFTLVVPPQVLLIPLYVFYQRFDILGLIKLIKGETLNLLNTYYPIVLPTILGGGLRSGLFIYIFRQFFRGMSKELEEAAYVDGASPFQTYLRIFVPNSIPAIVTVFLFSLVWHWNDVFEPSVFIGDFDKYTLSLNLANIRAIITGGTQIFDPLLILPPQYAGAILVILPMLIFYIFTQRFFVESVERTGIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2M5</accession>
    <name>B8E2M5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583944.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353483.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1596"/>
    <dbReference type="EnsemblBacteria" id="ACK42869">
        <property type="protein sequence ID" value="ACK42869"/>
        <property type="gene ID" value="Dtur_1596"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1596"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1646"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_88_3_0"/>
    <dbReference type="InParanoid" id="B8E2M5"/>
    <dbReference type="OMA" id="MCLFWGG"/>
    <dbReference type="OrthoDB" id="1268974at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003313">
        <property type="entry name" value="AraC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02311">
        <property type="entry name" value="AraC_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="187"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="287" mass="34547" checksum="647915EF6D9D3F68" modified="2009-03-03" version="1">MRIRKKELIESDVSHGTPDFPLFVHEDIFVYRNGIVNPHWHNEFEILYMERGIGMFYVDGYEYKLGEGEYLFVNSGSIHSGRELVRKSVGYAIVFDLRLLYSEEPDYCKHEYFLPLINKRYYIPTNINDENIRENILKIIEAFREKDYGYELYIKSLLFDTFWRVFKYYAKKQNQDGRLGYKIDRIKDLLSYINQNYNKNLSLDELSKQVDMSKFYLCRLFKESLKMSPVEYINKVRIDKAMELLINTDMSISEIAFECGFNNISYFIKVFRKYMHTTPLKFRKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2T2</accession>
    <name>B8E2T2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583514.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353046.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1153"/>
    <dbReference type="EnsemblBacteria" id="ACK42432">
        <property type="protein sequence ID" value="ACK42432"/>
        <property type="gene ID" value="Dtur_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1153"/>
    <dbReference type="eggNOG" id="COG3845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_0_0"/>
    <dbReference type="InParanoid" id="B8E2T2"/>
    <dbReference type="OMA" id="VGREMSH"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="257"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="510" mass="57419" checksum="B712486F1A840151" modified="2009-03-03" version="1">MEEIIKLEGITKTFPGVLANDNINLSIYQGEIHAIVGENGAGKSTLMKILYGLYKPDKGNIYIKGKRVVFDSPKDAIENGIGMVHQHFMLIPPFSVIENIILGSEVKNGVSLNFKKAESLIKELMEATGFKVELYTKVENLSVGEAQRVEILKLLYRRAEVLILDEPTAVLAPQEVEELFKVLRRLASQGKTIIFISHKLNEVLEISDRVSVMRRGKLVETLETKNTNKYQLAQLMVGREVFLRVEKEKIEKGEEIFRVENLWVKGRKGIEVVKGISFNIRAGEIVGIAGVEGNGQTELIESIVGLIPIQKGRIYIKGKDITLKNIRQRRLHIGHIPEDRHKRGLILDFSVAENSILGLHFYKDFSKGVFLDYKKVNSHAERIVKEFDVKTPNIKTPIRHLSGGNQQKVVVGREISFSPEFLIASQPTRGLDIGATEFIHQLLINLRNQGKAILLVSADLDEILSLSDRIIVMYNGEIVGSFLEGEVDEKELGYYMMGVKKQKELKEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2U3</accession>
    <name>B8E2U3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583525.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353057.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1164"/>
    <dbReference type="EnsemblBacteria" id="ACK42443">
        <property type="protein sequence ID" value="ACK42443"/>
        <property type="gene ID" value="Dtur_1164"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1164"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1201"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8E2U3"/>
    <dbReference type="OMA" id="EPLRTYY"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="37137" checksum="9F1E826B962FCF6F" modified="2009-03-03" version="1">MNNFSEEIIIEVKNLKKYFPIKRGIVLSKHVGDVKAVDDVSFYIRKGETLGLVGESGCGKSTVARTIIRLLEPTDGQIIFDGIDITKLPSRDLRKIRKDMQIIFQDPYSSLNPRMTVSEIIGEPLKVHGIVKNSKEKERRVQELLDLVGLAPYHATRYPHEFSGGQRQRIGIARALALNPKFIVADEPTSALDVSIRSQIINLMQDLQKEFKLTYLFISHDLAVIRHICDRIAVMYLGKIVEIANNDDLYNSPLHPYTQALLSAIPIPDPEMAKKRKKIVLTGDVPSPVNPPLGCRFHPRCPNVMDICSKEEPKLKEIKPGHFVACHLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E304</accession>
    <name>B8E304_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583586.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353118.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1226"/>
    <dbReference type="EnsemblBacteria" id="ACK42504">
        <property type="protein sequence ID" value="ACK42504"/>
        <property type="gene ID" value="Dtur_1226"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1226"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1265"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1364481_0_0_0"/>
    <dbReference type="InParanoid" id="B8E304"/>
    <dbReference type="OMA" id="CIFCIRN"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023821">
        <property type="entry name" value="rSAM_TatD-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01111">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04038">
        <property type="entry name" value="tatD_link_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="200" mass="22800" checksum="8F2B6D66BDF8CBDF" modified="2009-03-03" version="1">MSEIVYCLGSSLYLNITNRCTNRCVFCIKNFTDQVGNKRLVLDREPSSKEIIGSLNKIDLRTYKEVVFCGFGEPLIRVEVVKSVSRFIKDMFPHLPIRIDTNGHGNVFNQRNILPEIAPYIDAISISLNAEDKEKYDKISRPVFSDAYNAVIEFIKLSKIYIKDVAASVVNLPTVDIERCEKIAKDLGVKFKVREFVKSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E358</accession>
    <name>THIE_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-phosphate synthase</fullName>
            <shortName evidence="1">TP synthase</shortName>
            <shortName evidence="1">TPS</shortName>
            <ecNumber evidence="1">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="1">TMP pyrophosphorylase</shortName>
            <shortName evidence="1">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiE</name>
        <name type="ordered locus">Dtur_1660</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584007.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353546.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E358"/>
    <dbReference type="SMR" id="B8E358"/>
    <dbReference type="STRING" id="515635.Dtur_1660"/>
    <dbReference type="EnsemblBacteria" id="ACK42932">
        <property type="protein sequence ID" value="ACK42932"/>
        <property type="gene ID" value="Dtur_1660"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1660"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1710"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_2_0"/>
    <dbReference type="InParanoid" id="B8E358"/>
    <dbReference type="OMA" id="ITAFQFR"/>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000117299" description="Thiamine-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="45"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <sequence length="223" mass="25386" checksum="E46FDB43723EF7CC" modified="2009-03-03" version="1">MNKKEKLELLKDFNLYCLTCEEYSIGRKNIDVVREILEAGVKIIQYREKKKPMREKYHEVVKIRDLTAKYNALLIVNDHLDLTKIVEADGVHIGQEDYPIEVAKEFLGENFIIGLTTHTKEQVMEALRKGADYIGLGPIFPSYTKEKPHPPIGIEILDWAIKNISIPVVAIGGIKESNIHEILNLGAKCIAMVTEIVSSPNIYEKTRKIIHILEGYKNGKYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E397</accession>
    <name>B8E397_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic ribonucleoside-triphosphate reductase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584046.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353585.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1699"/>
    <dbReference type="EnsemblBacteria" id="ACK42971">
        <property type="protein sequence ID" value="ACK42971"/>
        <property type="gene ID" value="Dtur_1699"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1699"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1750"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078147_2_1_0"/>
    <dbReference type="InParanoid" id="B8E397"/>
    <dbReference type="OMA" id="MDIKAPL"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012840">
        <property type="entry name" value="NrdG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01094">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02495">
        <property type="entry name" value="NrdG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="13"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="228" mass="26608" checksum="5706E8C8DA8366C9" modified="2009-03-03" version="1">MKISGYLGFSLIDYPGIPSFVIFTQGCNFRCPFCHNPELISQRKKGQYSEEFILEEIDRRRKLIKGVVITGGEPTLQEDLPSFLFKLKKRRLLVKLDTNGSNPKMLVEIIKSKLLDYVAMDFKTSIPKYHKAIGLSERETSKYLKNIFESLRILKENNVRFEIRTTVVPEIVEEEDLIEIRKTIGEDVPYVLQPFKNDKTLSYEFKNKNPYPNELLEKYAFTVKGKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3B0</accession>
    <name>B8E3B0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation diffusion facilitator family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584059.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353598.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1712"/>
    <dbReference type="EnsemblBacteria" id="ACK42984">
        <property type="protein sequence ID" value="ACK42984"/>
        <property type="gene ID" value="Dtur_1712"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1712"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1763"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_3_0"/>
    <dbReference type="InParanoid" id="B8E3B0"/>
    <dbReference type="OMA" id="IEMHLIV"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015341">
        <property type="term" value="F:zinc efflux active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006876">
        <property type="term" value="P:cellular cadmium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:cellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="227"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="306" mass="34188" checksum="83129378B8DEB886" modified="2009-03-03" version="1">MNFSEWLSNKILTKKEYSKKYAGYLEGWVSIVGNLTLFLFKYFAGLSLGSISLIADAFHSLSDVFTSVVVILGFKLGSKPADKEHPYGHGRIEQIATLIIALLLLIVAYDLVRSSFERLMNPHKVEFNLGVFVLLIISAIFKEWMARFSIYLGKRFDASPLIADAWHHRSDAIATLLVTIGLLGSKLGFYRLDSILGVLVSLLIAWVGVDLLKSATSFLIGEAPSGDLVKKIDDIIVNTPGVLNYHDLSVHDYQNEKYITLHIEVDNNLTVKEAHDLALKVQDEIKSKIENSQVTVHIDPKGERED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3B6</accession>
    <name>B8E3B6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Appr-1-p processing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584065.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353604.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1718"/>
    <dbReference type="EnsemblBacteria" id="ACK42990">
        <property type="protein sequence ID" value="ACK42990"/>
        <property type="gene ID" value="Dtur_1718"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1718"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_7_0_0"/>
    <dbReference type="InParanoid" id="B8E3B6"/>
    <dbReference type="OMA" id="HYGKGLP"/>
    <dbReference type="OrthoDB" id="1812319at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="182" mass="19594" checksum="A427E71A9EAFC0CE" modified="2009-03-03" version="1">MDFLFEKEISGVKLKVVKGDITQEEVEAIVNAANSYLKHGGGVAGAIVRAGGEIIQKESDEYVKRYGPLPVGSATITSAGKLKAKYVIHTVGPQWGEGDEEKKLERAIESVLNLAKEKNIKSLSIPAVSCGIFGFPPELGTRVIVNKVVEFVKENPGVFKEIHFIGIGDDIPSLFAEALKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYH4</accession>
    <name>B8DYH4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recF</name>
        <name evidence="6" type="ordered locus">Dtur_0015</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582442.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351970.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0015"/>
    <dbReference type="EnsemblBacteria" id="ACK41356">
        <property type="protein sequence ID" value="ACK41356"/>
        <property type="gene ID" value="Dtur_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0015"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_0"/>
    <dbReference type="OMA" id="INVIYGP"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="AAA" evidence="5">
        <location>
            <begin position="27"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="340" mass="39802" checksum="E46F43C6DC71F938" modified="2009-03-03" version="1">MEKKRMVIESIYLRNFRNFSDFKTNFKDGINVIYGPNGSGKTSILEAVAYLSNPRSFRGARDHQLIKLGEKFFEINGKILSGNESHEITISYHHDEIKKEKIAYLDGFKVKRFRDIQEIFIAIPFSFKDYAMIDGYATQRRDFFDDIFSLLDLEYYEILRNYEKLLDERNDLLKEENIDRDYVIYLAKEMQPLAEKIVEKRETMIKELSKYLDPMFKVEYISEFKGKNIVDYIEEDIARGITTVGPHVHDDYTFYYKGNPAKYFASEGQKRLLYLSLVLAFRKLIEETKLYEPVFLFDDPVNVLDPHLLEKFISHLSGQVIIASLSPLLGAYNIGLTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYJ6</accession>
    <name>B8DYJ6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminotransferase class V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582464.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351992.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0040"/>
    <dbReference type="EnsemblBacteria" id="ACK41378">
        <property type="protein sequence ID" value="ACK41378"/>
        <property type="gene ID" value="Dtur_0040"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0040"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.41"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_1_1_0"/>
    <dbReference type="InParanoid" id="B8DYJ6"/>
    <dbReference type="OMA" id="KNWLPIM"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="5"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="385" mass="42106" checksum="0F0C3884C3F0BED0" modified="2009-03-03" version="1">MPKNYLLIPGPTPVPQDVLLEMAREMVNHRGAEFASVLKTSTELLKKVFKTQNDVLILTASGTGGMEAAVANFFSQGDPVLVGICGVFGERFAKICKTYGLNIKTIECEPGKGVEPEVLEKTLKENPDIKGVFLTHNETSTGVTNDLKELAPIVKQNPERLLVVDAVSSLGAIDLPTDELKIDIVVTASQKALETPPGLAMVSVSELAWKYNEKANLPRFYFDLKQAKKFLEEGATPFTPAVSVVFALKKALENILTRGLEENFKRHKFLGRAVREAIKALGVTRLLADERWASDTVTPVVPPENVNPDELRKYIRNKFGVVLAGGQGSLKGKIFRIGHLGYVEPTDILVAISAIEVALENLGYKGLKGKGVQVAEEVFAEYYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYK2</accession>
    <name>B8DYK2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582470.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351998.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0046"/>
    <dbReference type="EnsemblBacteria" id="ACK41384">
        <property type="protein sequence ID" value="ACK41384"/>
        <property type="gene ID" value="Dtur_0046"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0046"/>
    <dbReference type="HOGENOM" id="CLU_1934675_0_0_0"/>
    <dbReference type="OMA" id="PLCILEE"/>
    <dbReference type="OrthoDB" id="2138925at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="130" mass="15721" checksum="638D079F16747A24" modified="2009-03-03" version="1">MKIKKCPICEKIREEKEKRLKNLGKKVHLCKNHLKEAFTVNPNILELLEFEDNKECPICTLEKEITYAFQGEVKDLCLYHLRMLRDRIKDEDYEEIVERWKEYEKHLKEMDEQVELILDLLTGCGRIIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYK5</accession>
    <name>B8DYK5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase associated with various cellular activities AAA_3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582473.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352001.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0049"/>
    <dbReference type="EnsemblBacteria" id="ACK41387">
        <property type="protein sequence ID" value="ACK41387"/>
        <property type="gene ID" value="Dtur_0049"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0049"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.50"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_2_0"/>
    <dbReference type="InParanoid" id="B8DYK5"/>
    <dbReference type="OMA" id="FMARVSI"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="43"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="236"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="319" mass="36377" checksum="67D7E602E61B5275" modified="2009-03-03" version="1">MKTFLNEIVERLQLLRENIKKVIVGKDEVIDYVIVALLSRGNILLEDVPGVGKTVLAKSLAESIELDFRRIQFTPDTMPSDVLGVNVFNPKTLEFEFKPGPIFTNILLADEINRTSPRTQAGLLEAMDEGKVTIDGTTYELPKPFMVIATQNPREHFGTYPLPESQLDRFFISLSMGYLPMEEEVKMLENQKMIHPLERIEPVWKKEDLIKAQDLVKEIYIDKDILRYIVNIVNITRDDSLFSLGAGPRASISLMRGAQGYALLSGRDYVIPEDVIKMAVPILVHRVIPKEGSNMGRSFREDIIRDVLKRVKIPKVRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYK6</accession>
    <name>B8DYK6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582474.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352002.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0050"/>
    <dbReference type="EnsemblBacteria" id="ACK41388">
        <property type="protein sequence ID" value="ACK41388"/>
        <property type="gene ID" value="Dtur_0050"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0050"/>
    <dbReference type="HOGENOM" id="CLU_2878611_0_0_0"/>
    <dbReference type="OMA" id="HMIKTIR"/>
    <dbReference type="OrthoDB" id="2166678at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="63" mass="7646" checksum="08638BE6EC7188B1" modified="2009-03-03" version="1">MEFYRGVLVILFMGLILEIIVFIHYLSKWFFPFEFYLNLFDFFMTVGGIYAVIRHMIKTIRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYP5</accession>
    <name>B8DYP5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase expression/formation protein HypD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582513.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352041.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0089"/>
    <dbReference type="EnsemblBacteria" id="ACK41427">
        <property type="protein sequence ID" value="ACK41427"/>
        <property type="gene ID" value="Dtur_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0089"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.90"/>
    <dbReference type="eggNOG" id="COG0409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048562_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYP5"/>
    <dbReference type="OMA" id="HVCGSHE"/>
    <dbReference type="OrthoDB" id="666873at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070025">
        <property type="term" value="F:carbon monoxide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11750">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="352" mass="39585" checksum="E451134485F6012E" modified="2009-03-03" version="1">MEIKELLQKIKSISKKEINIMEFCGTHTHEIFRYGIRQILPENVHLLSGPGCPVCVTAEEDIDYIIALSEEYNLGIITFGDLVNVPGSLGSLNHLRAKGKEIKVIYSPLEALNIAKENPNKKYLLVGIGFETTAPHLAYTLIKAKEENIKNLYFLSLHKLTPPAMKAILDMGEIKLDGIIGPGHVSTIIGRTGWKEVFEAYRIPFVIMGFKPEEIIRGIYHLIKIIEEGEPKLLNTYEKSVKEEGNKYALETMYKIFKKGPANWRGLGVIENSGLLLKEEFEEFDVRKIYPLKIEKKPEKNNFCRCGEVLRGVLKPTDCPLFGKACTPENPKGPCMVSSEGTCSAYYLYGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYQ5</accession>
    <name>B8DYQ5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0175 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582523.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352051.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41437">
        <property type="protein sequence ID" value="ACK41437"/>
        <property type="gene ID" value="Dtur_0101"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0101"/>
    <dbReference type="HOGENOM" id="CLU_154570_4_1_0"/>
    <dbReference type="InParanoid" id="B8DYQ5"/>
    <dbReference type="OrthoDB" id="2031541at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005368">
        <property type="entry name" value="UPF0175"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03683">
        <property type="entry name" value="UPF0175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="87" mass="10243" checksum="4A432243BAE2DD37" modified="2009-03-03" version="1">MKLETLEIKIPKEILLQVRKEELIKEIKFLIAIDMYDRGILSLSKAALLAEMTKEEFMEILSEYGVDIIKYPKEELEEELENLKEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYQ9</accession>
    <name>B8DYQ9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582527.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352055.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0107"/>
    <dbReference type="EnsemblBacteria" id="ACK41441">
        <property type="protein sequence ID" value="ACK41441"/>
        <property type="gene ID" value="Dtur_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0107"/>
    <dbReference type="HOGENOM" id="CLU_2915034_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="61" mass="6884" checksum="2DAD7DAA1FBE8D1F" modified="2009-03-03" version="1">MFSIWLFIALLIFVILVPIFLPVFAQTPAVPTAQIQVKVNLPQGEELSDEELEKVEGQLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYR1</accession>
    <name>B8DYR1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582529.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352057.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0109"/>
    <dbReference type="EnsemblBacteria" id="ACK41443">
        <property type="protein sequence ID" value="ACK41443"/>
        <property type="gene ID" value="Dtur_0109"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0109"/>
    <dbReference type="HOGENOM" id="CLU_2129457_0_0_0"/>
    <dbReference type="OrthoDB" id="2158145at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="113" mass="11874" checksum="9D5BC42A2761BCCF" modified="2009-03-03" version="1">MIYNSSSRIGYGTLYDYAEYTSNAGPLVFGGAVVLLGSFYYNYDTRKVVSVNANVVASSGMFAEVTTSCSYGTVGTNIAWARGQANFRVYIGISGVGITVGSFSLSVSDSVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYT3</accession>
    <name>B8DYT3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-type ATPase subunit b</fullName>
            <shortName evidence="11">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpF</name>
        <name evidence="14" type="ordered locus">Dtur_0133</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="10 11">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582550.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352079.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0133"/>
    <dbReference type="EnsemblBacteria" id="ACK41465">
        <property type="protein sequence ID" value="ACK41465"/>
        <property type="gene ID" value="Dtur_0133"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0133"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132188_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYT3"/>
    <dbReference type="OMA" id="DWFTVIA"/>
    <dbReference type="OrthoDB" id="2114670at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="32"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK41465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="245" mass="28378" checksum="BC4AC6DF5428CF4A" modified="2009-03-03" version="1">MFSFNLLTIFSSIVNLLALAWIIKRYFLGAIIRIMNERREKIELAMKEAEKKLQEAEELRKQRESQLAQARDEAAKIVNEAIVTAEKMKRDITAKAEEEAEKIIVKAHEISMAERKRVLETAKKEVLSLSRLIIKEFFRRFLPVEAEELLINQFVDSLNLLIVNVKGDNIEEIRFVSPDNVSGQIKKKIEDKLRSLLPGSWKLNFELDPSIGLGFKLFIGEFLIDNSLDYHLSQIYDSIREVENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYW2</accession>
    <name>B8DYW2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582673.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352202.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0262"/>
    <dbReference type="EnsemblBacteria" id="ACK41588">
        <property type="protein sequence ID" value="ACK41588"/>
        <property type="gene ID" value="Dtur_0262"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0262"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.275"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_5_0_0"/>
    <dbReference type="InParanoid" id="B8DYW2"/>
    <dbReference type="OMA" id="WNDQQDS"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="265"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="395" mass="43535" checksum="EBAC2DD0EAE5B6BD" modified="2009-03-03" version="1">MKTQVKRIAIEGNEAAALAFKQVNPDVVAAYPITPSTEVVQKFSEYVANGEVDTEFVPVESEHSAMSACIGAAAAGARVMTSTASQGLALMWEMLYIASALRLPIVMTVANRALSAPINIHGDHSDAMGARDSGWIQIFSENVQEIYDNIFQAVKIAEHPDVRLPVMVGYDGFITSHSEEMIEVLDDEVVRNFIGKYKPQYTLLDVDNPIAVGPLALTDSYFEFKVAQAYALENSLPIIKHVGKEYGDITGRYYDVIEKYKTEGAEYIIVAMSSTVGTAREVVDALREKGLPVGLLKIRVFRPFPTEDIINALKDAKVIGILDRSMVPGSFGGPLYHEITSAFYHYDKRPIAQAYVYGLGGRDITTQHIEKVFEELMDIGKKGKPNPLTYIGVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYW5</accession>
    <name>B8DYW5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl xylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582676.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352205.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="ESTHER" id="dict6-b5ycd5">
        <property type="family name" value="Acetyl-esterase_deacetylase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S09.949"/>
    <dbReference type="EnsemblBacteria" id="ACK41591">
        <property type="protein sequence ID" value="ACK41591"/>
        <property type="gene ID" value="Dtur_0265"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0265"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.278"/>
    <dbReference type="eggNOG" id="COG3458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054209_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYW5"/>
    <dbReference type="OMA" id="VHFAARG"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008391">
        <property type="entry name" value="AXE1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039069">
        <property type="entry name" value="CE7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40111">
        <property type="entry name" value="PTHR40111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05448">
        <property type="entry name" value="AXE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AXE1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="328" mass="37692" checksum="EC1B7771A1278424" modified="2009-03-03" version="1">MAFFDLPLLELWKYFPEREEPEDFDFFWKETLEESRKYPLDPIFEKVDFGLELVDTYDVTFSGYKGQRIKGWLIVPKNRSGKLPGIVEYIGYGGGRSFAYDFLLWANMGFIHLIMDTRGQGSSWSPGDTPDYDDEPFDPQYSGFMTRGILHPKKYYYRRVFTDAVRAVETIMAFPDVDKERIGITGGSQGGGITIAVAGLVPYIGIDVKIVMPDVPFLCHYRRAVEITDGYPYQEIVQYLKSHRDHVDRVFKTLSYFDGVNFAVRAKAKALFSVALMDNICPPSTVFAAYNYYQGEKEIKIYPFNGHEGGGTFHTYEKMKFAKKYLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYX2</accession>
    <name>B8DYX2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582683.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352212.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0272"/>
    <dbReference type="EnsemblBacteria" id="ACK41598">
        <property type="protein sequence ID" value="ACK41598"/>
        <property type="gene ID" value="Dtur_0272"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0272"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYX2"/>
    <dbReference type="OMA" id="VASHTHF"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="245" mass="27981" checksum="9C91F3BA4E9A359A" modified="2009-03-03" version="1">METDKYISRLVEENVYHISDYRDDSFYLIIGENKAILFDTGMGTGDLKKYIGSLTNKDVEVVISHAHWDHIMQVNQFEKVYMNHKDIEIIKIFKMDIKYDHFLDIKDGDILDIGGRKLEVIEVPGHTPGSIVLLDNKYKLLFSGDAIGAGHTWMQLPGCLPLSSYLESLHKLAKRSNEFEKIYNGHLAQRNGIPVPREYLFDLIKAVEKVISGELMGEPYPYGNFGGLYVNYGMATLVYNPQNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYY2</accession>
    <name>B8DYY2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PAS/PAC sensor hybrid histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582693.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352222.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0284"/>
    <dbReference type="EnsemblBacteria" id="ACK41608">
        <property type="protein sequence ID" value="ACK41608"/>
        <property type="gene ID" value="Dtur_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0284"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_51_0"/>
    <dbReference type="InParanoid" id="B8DYY2"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="73"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="185"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="376"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="462" mass="52431" checksum="DEC759D65007F6C0" modified="2009-03-03" version="1">MNLNYLIIENLQERAEFIRKELAKEFNLNSLIAIPIYSENEFIGVCDKKKTELSPSLAVQIARVFETKKSIAKIQELLRLIDISDDAIIVLDEEDKVLFWNQGAEKLYGISKMDALGKNINKILSYSYEAIKGKLISKRKWIGEIEQRKSGGERILVGSFMELVKNEEEEGYKIFIRNTDITFIRRLQEQLNRAQKLESIGNLASGIAHDLNNIFTPKNIDIKIEISGELHPILGDPTSINQVLLNLCVNAKDAMPNGGVLTIKVENVYIDEDYAKWNPMSKVGDYVVITVADTGIGIPKDVMDKIFDPYFTTKGEKGTGLGLSTVYTIVKEHEGFINVYSEEGKGTVFKVYIPAISNHKNKKEEDRKEISEKKSYVLVVEDEKHIREIVKDMLERNNLNVLLAENGKEAVKILEKNKELINLAIVDYNLSDVKGDVLIGEIKAMLPELKIILMKNKQYSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ34</accession>
    <name>B8DZ34_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582745.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352274.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0347"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41660">
        <property type="protein sequence ID" value="ACK41660"/>
        <property type="gene ID" value="Dtur_0347"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0347"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_27_5_0"/>
    <dbReference type="InParanoid" id="B8DZ34"/>
    <dbReference type="OMA" id="EAYMAAD"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="58"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="180"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="369" mass="42956" checksum="038CF1E600955857" modified="2009-03-03" version="1">MTKVLLDARMIDSSGIGTYLQNLIPFLKNHLNLSLLGEREKVEEYIDISNLNFISMKSPIYFPTEQIEFLLKIKDVDIFWSPHFNVPVFPIRAKKRIVTIHDVFHLAFGELYSPFERTYAKFLINSSVNLSDVIITVSNFSKSEIIKYTGVKEEKIKVIYNGVDRERFRVYEKEELEKIKSEYKLPNRFLLFVGNVKPHKNLRRLLKAFKIIAGDFKDLFLVITGQKEGFLKGDKKIFELINKDTILKERVIFTGHVDKGDLPYLYNLAEIFVFPSLYEGFGLPPLEAMACGCPIVVSHIPPLWEICKDAAYYINPHDEWDIAKGIKEVLENEKLRKELIDKGIERAKEFSWEKSAREHLNLIEKTLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ46</accession>
    <name>B8DZ46_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582757.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352286.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0361"/>
    <dbReference type="EnsemblBacteria" id="ACK41672">
        <property type="protein sequence ID" value="ACK41672"/>
        <property type="gene ID" value="Dtur_0361"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0361"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.381"/>
    <dbReference type="eggNOG" id="COG4907">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026556_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZ46"/>
    <dbReference type="OMA" id="EHPPESI"/>
    <dbReference type="OrthoDB" id="556665at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018702">
        <property type="entry name" value="DUF2207_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09972">
        <property type="entry name" value="DUF2207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="607" mass="69767" checksum="C9218B9148D1DE5B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ53</accession>
    <name>B8DZ53_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582764.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352293.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0375"/>
    <dbReference type="EnsemblBacteria" id="ACK41679">
        <property type="protein sequence ID" value="ACK41679"/>
        <property type="gene ID" value="Dtur_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0375"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_10_5_0"/>
    <dbReference type="InParanoid" id="B8DZ53"/>
    <dbReference type="OMA" id="TFMFRGG"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="421" mass="48408" checksum="5060680536EE8A9A" modified="2009-03-03" version="1">MRKFLFISLISLILLSLSALGQSKIQITYMRWGDIREIEVERKIVDAFNQSQNKIFVNLESAAWGAYWQQLQNRIAAGNAPDVMLISGAYFIDLASKGVFKDITDWAKKDINFKNYYYNPELCEWDGKIYAMIRDITLGGIMFYNKDIFDKYKIKYPDWSWDWNKWIEAAQKLTIDENKDGTPEIWGTYVPTWGEGGLYPIIWSAGGTVLSKDKKSCTIYSNPKSLEGLKFMYELRYKYKVCPSESFMQGLSDPFMTGNFATTLGISSFIVSYRKLPFRWGIAPIPSGPAGRFMSANQLSLAIYSKSKYPEAAWEFIKFATGPKGQEIMGKEHQAIPALKLKTRVYFDDPNIKSALTIFSLYEKGQLKSLEFTPSWLEWNNMLETTLGYAWQGKVDIEKAAKTAEDRVNKILQEAWKKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ63</accession>
    <name>B8DZ63_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tagatose-6-phosphate kinase</fullName>
            <ecNumber evidence="2">2.7.1.144</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.144" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582774.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352303.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DZ63"/>
    <dbReference type="STRING" id="515635.Dtur_0385"/>
    <dbReference type="EnsemblBacteria" id="ACK41689">
        <property type="protein sequence ID" value="ACK41689"/>
        <property type="gene ID" value="Dtur_0385"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0385"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.405"/>
    <dbReference type="eggNOG" id="COG4573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053334_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ63"/>
    <dbReference type="OMA" id="QRHFSYS"/>
    <dbReference type="OrthoDB" id="395879at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009024">
        <property type="term" value="F:tagatose-6-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012062">
        <property type="entry name" value="GatZ/KbaZ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08013">
        <property type="entry name" value="GatZ_KbaZ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009264">
        <property type="entry name" value="TagBP_ald_AgaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="408" mass="47862" checksum="D8D429CC067FCDC0" modified="2009-03-03" version="1">MWLSKDYLRKKGVYSICSSNSYVIEASIEFAKEKGDYILIEATPHQVNQFGGYSGMTPEDFKNFVMKIAKEKGLEEDKIILGGDHLGPLPWQDEPSPTAMNKAKDLIRAFVESGYKKIHIDCSMPLSDDPKVLPYEKIAERTRELFEIAEETARKYNFQPVYVVGTDVPIAGGGEEEGVTSVEDFRSAISSLKKYFNDVPNIWDRVVGFVIMLGIGFSYDKVFEYDRDKVRGILEEVKREDLFVEGHSTDYQARYALRNMVEDGVRILKVGPALTAAFRRGVFLLSNIEDEIIPERERSNIKRVILETMLRDDRYWRKYYKDSKRLELDIWYNLLDRIRYYWEYEDVKMVLNKLFENFSEGVDIKFIYQYFYDSYFDVREGKMKNDPRELIKKEIKRVLEDYSYAINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ73</accession>
    <name>B8DZ73_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DsrF/TusC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582891.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352420.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0513"/>
    <dbReference type="EnsemblBacteria" id="ACK41806">
        <property type="protein sequence ID" value="ACK41806"/>
        <property type="gene ID" value="Dtur_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0513"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.544"/>
    <dbReference type="eggNOG" id="COG2923">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2070287_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ73"/>
    <dbReference type="OMA" id="RSAFGMY"/>
    <dbReference type="OrthoDB" id="1847984at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017462">
        <property type="entry name" value="Sulphur_relay_TusC/DsrF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38780">
        <property type="entry name" value="PTHR38780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="119" mass="13752" checksum="0F70AF6D02E6B299" modified="2009-03-03" version="1">MKRVLFVVYQSPAGSIWVNEALRSAFGMYGEDLEPSILFMEDAVVAVNKNTHPENLGCLSLSMSFKYLERYGTPIYVVKEDLEKRKIKEEDVEPTWKAKIISQNEVSEFIHSFDRVIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ78</accession>
    <name>B8DZ78_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, periplasmic ligand binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582896.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352425.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0518"/>
    <dbReference type="EnsemblBacteria" id="ACK41811">
        <property type="protein sequence ID" value="ACK41811"/>
        <property type="gene ID" value="Dtur_0518"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0518"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.551"/>
    <dbReference type="eggNOG" id="COG4134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_722939_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ78"/>
    <dbReference type="OMA" id="WDINPRA"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="385" mass="43612" checksum="440884AC9044804D" modified="2009-03-03" version="1">MRKKSILFVILTITLLFLMIANLGAQTKKVRLSIIDVAGNLQLTKTAIEAFKKAHPDLIEDIEYLKATAPELPAKIKAQQMAGNVTTTMVLTGYDAMASGLEMDLWENIYPTYKQYFPNLESRYLPGAKAAFDLFKGYGIVVTYCPGGPMFTYNPEKVKRVPQTAEELLEWAKQNPGKFMYARPANSGPGRAFLQGLPYILGDKNPKDPKTWEKTWAYLKELDKYIDYYPTGTAITFRELAEGTRWIIASHLGWDMNQRILGVIPSNFKAFFLKNTTWVTDAHFMCMPKGLDEARKRATLQLMSWLLRAEMQALTYDDGYFYPGPAIKGVPLSAAPKETQDKIKAAMRTEYERAIKEFPSTTQLGAKELVEAFDMWDRMIGAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ92</accession>
    <name>B8DZ92_DICTD</name>
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        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582910.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352439.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0535"/>
    <dbReference type="EnsemblBacteria" id="ACK41825">
        <property type="protein sequence ID" value="ACK41825"/>
        <property type="gene ID" value="Dtur_0535"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0535"/>
    <dbReference type="eggNOG" id="COG1237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ92"/>
    <dbReference type="OMA" id="CSGWRAK"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="262" mass="30318" checksum="E0B4C6C3CE646E3E" modified="2009-03-03" version="1">MYQNFLTKITVLCDDRLSPPLFSEHGFSVLIEREGESPILFDTGSSDVFIKNAEVLGKDLSKVENIIISHGHYDHAGGLKYLSKSHRRFRIFLREEAFLPKYSDERFTGVDWESLKSFLEFVIVKDEVLKISDSIYIFGSVPFQNDFEEPDPHFYVVKEGRKLRDFFDEEINLIIDEGDGIILITGCAHRGIVNIVEYAIKKFNKKIKLLMGGFHLYKAPSSKVEKVINILQKFNIDKIIPYHCSGEEMIKILNERENFRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZC5</accession>
    <name>B8DZC5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582943.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352472.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0568"/>
    <dbReference type="EnsemblBacteria" id="ACK41858">
        <property type="protein sequence ID" value="ACK41858"/>
        <property type="gene ID" value="Dtur_0568"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0568"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="InParanoid" id="B8DZC5"/>
    <dbReference type="OMA" id="KSAWKSQ"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="364"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="578" mass="66884" checksum="4C918930AC14F4D4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZI5</accession>
    <name>B8DZI5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-binding alcohol dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352532.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0630"/>
    <dbReference type="EnsemblBacteria" id="ACK41918">
        <property type="protein sequence ID" value="ACK41918"/>
        <property type="gene ID" value="Dtur_0630"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0630"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.667"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_7_0"/>
    <dbReference type="InParanoid" id="B8DZI5"/>
    <dbReference type="OMA" id="GIPWLGH"/>
    <dbReference type="OrthoDB" id="969875at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08298">
        <property type="entry name" value="CAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014187">
        <property type="entry name" value="ADH_Zn_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02822">
        <property type="entry name" value="adh_fam_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="34"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="344" mass="38805" checksum="7D5BDDDFFE6046A6" modified="2009-03-03" version="1">MKMKAMLLKEIKNLSIDRNPLTLEEIEVPTPKEKEILIEVYACGVCRTDLDIIEGRTLPSKFPIILGHQIVGRVVEKGKNANKFSIGERVGIAWINSSCGKCKYCLSGQENLCDEFKATGRDVDGGYAEYTVVSEDFAYKIPENYSDEESAPLLCAGAVGYRSLKLTNIKDGDNIGLSGFGASGHLVLKMIKFLYPSSKIFVFARSKEERNFAKELSAYWTGDFDEDPPEKLKAIIDTTPAWKPIISVLKNLEKGGRLVINAIRKEEGDKEFLLNLKYERDLWMEKEIKSVANVTRKDVEEFLKIAEKLNFKPEIQIYPLEEANKALLELKEGKIRGAKVLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZI9</accession>
    <name>B8DZI9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cna protein B-type domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583007.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352536.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0637"/>
    <dbReference type="EnsemblBacteria" id="ACK41922">
        <property type="protein sequence ID" value="ACK41922"/>
        <property type="gene ID" value="Dtur_0637"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0637"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_701562_0_0_0"/>
    <dbReference type="OMA" id="GNYASHG"/>
    <dbReference type="OrthoDB" id="1522859at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867595" evidence="1">
        <location>
            <begin position="20"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="393" mass="43971" checksum="6F88ED118FF2023A" modified="2009-03-03" version="1">MRKLALFSLILITSGIFLSGCTQKATTNPGEINVGLGDSIIQGIVNYFDKPTNQSANIKVTLIPESEESPLNLDSYYVITGNNGSYKFQNIPSGTYLLLAQDVNKEYQPANLVITVGENEVKTSEMMILTKVIKHVIIFRENSSAWSQAGVPTTVIGDILSSIGMTEGTGQNQYEYRELNIENPNLDFNLGNLVIIEGDQPQGFYDVYTNNKNAFDNFVYNGGTIFWIACDMGWENGNFSSTLPGGVSWRDAYENYNDIVYFEHPITKNFPAQLYGNYASHGGFNNLDSINISNLMVYVKENYGDGSSQYPTYIEYRYNMGKVLATTTPLEWYVVNGPTSCPEGYTTTYKDLFKLMLVRSLRYIMNLDVSPDIPPSAEEVYSPKIKTNLNSHK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2013-03-06" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZK4</accession>
    <name>CEEP_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cellobiose 2-epimerase</fullName>
            <shortName evidence="1">CE</shortName>
            <ecNumber evidence="1">5.1.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_0652</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2012" name="Biotechnol. Lett." volume="34" first="2061" last="2068">
            <title>Characterization of a recombinant cellobiose 2-epimerase from Dictyoglomus turgidum that epimerizes and isomerizes beta-1,4- and alpha-1,4-gluco-oligosaccharides.</title>
            <authorList>
                <person name="Kim J.E."/>
                <person name="Kim Y.S."/>
                <person name="Kang L.W."/>
                <person name="Oh D.K."/>
            </authorList>
            <dbReference type="PubMed" id="22782272"/>
            <dbReference type="DOI" id="10.1007/s10529-012-0999-z"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man). Catalyzes epimerization but also isomerization for beta-1,4- and alpha-1,4-gluco-oligosaccharides. Can use cellobiose, lactose, cellotriose, maltose and maltotriose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>D-cellobiose = beta-D-glucosyl-(1-&gt;4)-D-mannopyranose</text>
            <dbReference type="Rhea" id="RHEA:23384"/>
            <dbReference type="ChEBI" id="CHEBI:17057"/>
            <dbReference type="ChEBI" id="CHEBI:47931"/>
            <dbReference type="EC" id="5.1.3.11"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">75.8 mM for cellobiose</KM>
            <KM evidence="2">79.6 mM for lactose</KM>
            <text>kcat is 169 min(-1) for cellobiose. kcat is 89.4 min(-1) for lactose.</text>
        </kinetics>
        <phDependence>
            <text evidence="2">Optimum pH is 7.0.</text>
        </phDependence>
        <temperatureDependence>
            <text evidence="2">Optimum temperature is 70 degrees Celsius.</text>
        </temperatureDependence>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cellobiose 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.11" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583022.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352551.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZK4"/>
    <dbReference type="SMR" id="B8DZK4"/>
    <dbReference type="STRING" id="515635.Dtur_0652"/>
    <dbReference type="EnsemblBacteria" id="ACK41937">
        <property type="protein sequence ID" value="ACK41937"/>
        <property type="gene ID" value="Dtur_0652"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0652"/>
    <dbReference type="eggNOG" id="COG2942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046651_3_0_0"/>
    <dbReference type="InParanoid" id="B8DZK4"/>
    <dbReference type="OMA" id="WVQAETF"/>
    <dbReference type="OrthoDB" id="783590at2"/>
    <dbReference type="BRENDA" id="5.1.3.11">
        <property type="organism ID" value="13721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047736">
        <property type="term" value="F:cellobiose epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050121">
        <property type="term" value="F:N-acylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006051">
        <property type="term" value="P:N-acetylmannosamine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00929">
        <property type="entry name" value="Cellobiose_2_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028584">
        <property type="entry name" value="Cellobiose_2_epim"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000421445" description="Cellobiose 2-epimerase">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="22782272"/>
        </source>
    </evidence>
    <sequence length="389" mass="46393" checksum="EF819E43953C6BA6" modified="2009-03-03" version="1">MDLKVLKSEIFEHLNNKIIPFWEELKDENNGGYISYVGFDLKPDPYAPKGLVLTSRILWFFSRLYNQLRKEEFINFADHSYKFLIKSFLDKENKGFYWMVDYKGEPIDKRKHLYGQAFVLYGLSEYYKATQKKESLDLALEIYKIIEEVCKNDVGYKEEFDEKWNPKENIIVSEYGIICERSMNTLLHILEAYTNLFTATYDQSIKKKIEDLIILFKEKIYDSKTNHLYVFFDKKMNPIIDAISYGHDIEATWLIDEALRYIDNNKLIKEMSEINLKIAEKVLEEAFESGSLLNERVRGIVDKNRIWWVQAEALVGFLNAYQKSKLDKFLKAVFELWEFIKDFLVDKRAQGEWFWKLDENYIPSPMPEVDLWKCPYHNGRMCLEVIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZM7</accession>
    <name>B8DZM7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583045.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352574.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0675"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41960">
        <property type="protein sequence ID" value="ACK41960"/>
        <property type="gene ID" value="Dtur_0675"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0675"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005603_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZM7"/>
    <dbReference type="OMA" id="QDGYGPD"/>
    <dbReference type="OrthoDB" id="45650at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019248">
        <property type="entry name" value="Glucodextran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09985">
        <property type="entry name" value="Glucodextran_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="2">
        <location>
            <begin position="44"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Glucodextran_C" evidence="3">
        <location>
            <begin position="800"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1042" mass="120594" checksum="047577EFFBD94D27" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZP3</accession>
    <name>B8DZP3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine amidotransferase of anthranilate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583061.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352590.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0691"/>
    <dbReference type="MEROPS" id="C26.955"/>
    <dbReference type="EnsemblBacteria" id="ACK41976">
        <property type="protein sequence ID" value="ACK41976"/>
        <property type="gene ID" value="Dtur_0691"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0691"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZP3"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="192" mass="21584" checksum="683279CDEFE3A06C" modified="2009-03-03" version="1">MVLLIDNYDSFTYNLYQYVAEFCKVKVYRNDKITIEDIYKLNPQAIIISPGPSIPENAGVSIPVVKEFKNKLPILGICLGHQAIAAAFGTKIVRAPVPVHGKVSYIYHSQNPIFEGINNPFEATRYHSLVVDIDSLSSSLKVIAWTQDKLIMGIQYEDKPVYGLQFHPESIFTTFGKRIIKNFLKIGGVIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZS7</accession>
    <name>B8DZS7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583095.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352624.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0727"/>
    <dbReference type="EnsemblBacteria" id="ACK42010">
        <property type="protein sequence ID" value="ACK42010"/>
        <property type="gene ID" value="Dtur_0727"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0727"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.766"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_265249_0_0_0"/>
    <dbReference type="OMA" id="EPGMPGW"/>
    <dbReference type="OrthoDB" id="956262at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024618">
        <property type="entry name" value="DUF3857"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12969">
        <property type="entry name" value="DUF3857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870996" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="568"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3857" evidence="4">
        <location>
            <begin position="652"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="3">
        <location>
            <begin position="865"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1225" mass="144626" checksum="99355762F0452D8F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZT1</accession>
    <name>B8DZT1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uroporphyrinogen decarboxylase (URO-D)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352628.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0731"/>
    <dbReference type="EnsemblBacteria" id="ACK42014">
        <property type="protein sequence ID" value="ACK42014"/>
        <property type="gene ID" value="Dtur_0731"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0731"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.770"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_2_1_0"/>
    <dbReference type="InParanoid" id="B8DZT1"/>
    <dbReference type="OMA" id="IHICGRL"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="319" mass="35909" checksum="282C7403547AC21C" modified="2009-03-03" version="1">MMISEKKRLVIPLLGAPGIKLTGTTLKQNLIDPSIQFKTLYKILERFNPDGIFPFMDLTVEAEALGLKIDFPENENPSVREHPIKDREALAELKRKWNGISGRMKVFIKVCEMMVKEFDRIKGGYVIGPFTLAGELMGVNDLGINVLEEPEFVKEVVEFTTKVILEYAKVLFETGIDVVAVLEPTAVILSPQLFKEFSMKYFKYLSSEIKRPLIYHICGNTKHLIEDMGKSGAWGLSLDSAVDLKWASEIVPSKVNLIGNLDPVGVFLQGSPEMVYERTWKLLERMKDVENFILSSGCDIPVGTPLENIDAFMQAAKNF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZW4</accession>
    <name>FLOA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flotillin-like protein FloA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">floA</name>
        <name type="ordered locus">Dtur_0765</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts. FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooligomerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane raft</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flotillin-like FloA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583132.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352661.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZW4"/>
    <dbReference type="SMR" id="B8DZW4"/>
    <dbReference type="STRING" id="515635.Dtur_0765"/>
    <dbReference type="EnsemblBacteria" id="ACK42047">
        <property type="protein sequence ID" value="ACK42047"/>
        <property type="gene ID" value="Dtur_0765"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0765"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.802"/>
    <dbReference type="eggNOG" id="COG4864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836378_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZW4"/>
    <dbReference type="OMA" id="GIMDYYR"/>
    <dbReference type="OrthoDB" id="827327at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01562">
        <property type="entry name" value="FloA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022853">
        <property type="entry name" value="FloA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12127">
        <property type="entry name" value="YdfA_immunity"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000199713" description="Flotillin-like protein FloA">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01562"/>
        </source>
    </evidence>
    <sequence length="329" mass="35210" checksum="F0FEF50156C4AFB1" modified="2009-03-03" version="1">MNLIWGFLILILVLIFLGVFFSFVPLGLWISALAAGVSIRITDLIGMRLRRVPPGVIINSLIKAHKAGLSEVTLDKLEAHYLAGGNVDKVVNALIAAQRAGIPLTFEKAAAIDLAGRDVLEAVQMSVNPKVIETPVVAAVAKDGIELKAKARVTVRANIERLVGGAGEATIIARVGEGIVTTIGSAESYKEVLENPDSISKTVLAKGLDAGTAFEIVSIDIADVDVGNNVGARLKMDQAEADMRIAQAQAESRRALAIAREQEMKALTQEMRARLIEAEKEVPLAIAEALRSGKIGVLDYYTLKNIIADTAMREAISKLGQKEEEGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZW5</accession>
    <name>B8DZW5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NfeD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583133.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352662.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0766"/>
    <dbReference type="EnsemblBacteria" id="ACK42048">
        <property type="protein sequence ID" value="ACK42048"/>
        <property type="gene ID" value="Dtur_0766"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0766"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.803"/>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024619_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZW5"/>
    <dbReference type="OMA" id="QMDTPGG"/>
    <dbReference type="OrthoDB" id="973681at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002825">
        <property type="entry name" value="Pept_S49_ser-pept_pro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01972">
        <property type="entry name" value="SDH_sah"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867601" description="NfeD domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="4">
        <location>
            <begin position="323"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="423" mass="46747" checksum="9FFBE17E38780CC0" modified="2009-03-03" version="1">MKKILYTILFSFLLLSFLNAQPQNVYVIPIKGTIELGLASFVERSLKENPNAKAFIFEIDTFGGRVDAAIRIRDAILSTPNLTIAFIKDRAWSAGALIALSCEKIIISPSGSIGAAEPRPAEEKTISALKAEFESTAKKRQRNPKIAAAMVDADEVIPGLKQKGKILTLYAEEAKKWKIADEILEDLDSVLKYFRLEKAKVTNLHPNWAENFVRFITDPTVSSIILTIGMLSLYVAIFTPGLGLPELLALICLGLFFGGHYLAGLAGLEPLILFILGLILIFIEMHTPGFGIPGIAGSISVFLSIYWTIVQKGGTFQALLTGIFVVLSLIIFLAIYLPRSRVWKKFGLSGSQKKELGYTAVQERKDLIGKKGKTITMLRPTGIIEIDGERFEAYSESEFIEPGEEVLVFKVEGNKIFVRRSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZX1</accession>
    <name>B8DZX1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583139.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352668.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0772"/>
    <dbReference type="EnsemblBacteria" id="ACK42054">
        <property type="protein sequence ID" value="ACK42054"/>
        <property type="gene ID" value="Dtur_0772"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0772"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.809"/>
    <dbReference type="eggNOG" id="COG1415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061722_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZX1"/>
    <dbReference type="OMA" id="VIQQGMN"/>
    <dbReference type="OrthoDB" id="546749at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008482">
        <property type="entry name" value="DUF763"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38597">
        <property type="entry name" value="PTHR38597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05559">
        <property type="entry name" value="DUF763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="358" mass="41101" checksum="73BC92F1112782E9" modified="2009-03-03" version="1">MFKREIAELPLHSGKAPAWLFQRMKKLAREIILIFAIENRTDEFLRKLSDPFWFQALGCILGFDWHSSGLTTTTGAALKEGLGELSHEIGLYIVGGKGKTALNTPEEITKLAEKEGFDPQKWIFISRIVARVDNNAIQDGYQLYHHLLIFTKKGTWCVIQQGMNNKNNFARRYHWLGEELKSFTEEPHKGIITQKFEDYVVNLVAKESKQTQEIITTLMKEDPNKVISLWNKVSLKLPSYHPITPKEIKSENLKKILLKTYEAPPKDFQEVLLKEGVGAKTLRALTLISELVYDAPASIKDPARFSFAHGGKDGHPYPVDKKNYDKTIEILERAIKNAKLGRREELETLKRLSFYFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZZ6</accession>
    <name>B8DZZ6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease Y</fullName>
            <shortName evidence="5">RNase Y</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rny</name>
        <name evidence="8" type="ordered locus">Dtur_0798</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352693.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0798"/>
    <dbReference type="EnsemblBacteria" id="ACK42079">
        <property type="protein sequence ID" value="ACK42079"/>
        <property type="gene ID" value="Dtur_0798"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0798"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.836"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028328_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZZ6"/>
    <dbReference type="OMA" id="PHAILGM"/>
    <dbReference type="OrthoDB" id="1012190at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3 5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HD" evidence="7">
        <location>
            <begin position="303"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="487" mass="56093" checksum="AA8F3652E2D6F11D" modified="2009-03-03" version="1">MGYFVRKYIESKTVQLAEKRAEEIKKKAEEEAEEKRRRALLEAKEEIFKLRSEAEREIRERRNELINLERRILQREENLERKEEILANKEKEINHRLENIKKLEEEAIIELQKVAQMTKEEAKEILLRHVEDEIQKDIALRIKEAEARYKEIAEEKAREIIMEAIQRCAVDHTVESTVSVVSLPSEEMKGRIIGREGRNIRTFETLTGVDLIIDDTPEAVVLSSFDPVRREIARIALERLVKDGRIHPARIEEMVNKAKKEVENRIREEGERALIEVGIQNIHPDLVRTLGRLYYRTSYGQNVLQHSIEVAKIATIIAAELHMDVNLAKRAGLLHDIGKAIDYEVEGSHAVLGAELLKKYGEHPDVVHAVAAHHEEIPLIKPLDVIIQVADSISAVRPGARRESIEIYIKRLEKLEEIAMSFPGVEKAYAIQAGREVRVLVSPEEVDDLTATRLAYQIAKKIEKEMEYPGQIKVTVIRETRAVEYAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E001</accession>
    <name>KITH_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thymidine kinase</fullName>
            <ecNumber evidence="1">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tdk</name>
        <name type="ordered locus">Dtur_0803</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thymidine = ADP + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583168.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352698.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E001"/>
    <dbReference type="SMR" id="B8E001"/>
    <dbReference type="STRING" id="515635.Dtur_0803"/>
    <dbReference type="EnsemblBacteria" id="ACK42084">
        <property type="protein sequence ID" value="ACK42084"/>
        <property type="gene ID" value="Dtur_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0803"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.841"/>
    <dbReference type="eggNOG" id="COG1435">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064400_3_0_0"/>
    <dbReference type="InParanoid" id="B8E001"/>
    <dbReference type="OMA" id="ENTVNHK"/>
    <dbReference type="OrthoDB" id="1279539at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020633">
        <property type="entry name" value="Thymidine_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="PTHR11441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00603">
        <property type="entry name" value="TK_CELLULAR_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0237">DNA synthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000117666" description="Thymidine kinase">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00124"/>
        </source>
    </evidence>
    <sequence length="198" mass="22341" checksum="05561B8A57BBDAB1" modified="2009-03-03" version="1">MEIVSGASGWIEVICGGMYSGKSEELIRRVRRAQIAKQKVQVFKHSLDIRYDKDYVASHTGLKIEAIPVSSSADIERLVKDDTQVVAIEEGQFFDMGLVKVCQRLADRGKRVIVAGLDQDFRGEPFGPMPYLMAVAEYVDKLHAICMKCGNVASRTQRIIDGKPAYYDDPIILVGAFETYEARCRHCHVVLRREEDEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E008</accession>
    <name>GLYA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="1">SHMT</shortName>
            <shortName evidence="1">Serine methylase</shortName>
            <ecNumber evidence="1">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyA</name>
        <name type="ordered locus">Dtur_0810</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583175.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352705.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E008"/>
    <dbReference type="SMR" id="B8E008"/>
    <dbReference type="STRING" id="515635.Dtur_0810"/>
    <dbReference type="EnsemblBacteria" id="ACK42091">
        <property type="protein sequence ID" value="ACK42091"/>
        <property type="gene ID" value="Dtur_0810"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0810"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.848"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_0"/>
    <dbReference type="InParanoid" id="B8E008"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070905">
        <property type="term" value="F:serine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046653">
        <property type="term" value="P:tetrahydrofolate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000116827" description="Serine hydroxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in substrate specificity" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <sequence length="414" mass="46270" checksum="63FCE3778F3808FC" modified="2009-03-03" version="1">MRYLPEVDPEIYEAIKSEEYREEYHLELIASENFVSRAVLEAQGSVLTNKYAEGYPGKRYYGGCLYVDKVEDIARERVKAIYGAEHANVQPHSGSQANMAVYFVVLNPGDRVLGMNLAHGGHLTHGSPVNFSGKLYNFYFYGVDKNTEMINYDSVWNLAKELKPKLIVAGASAYPRIIDFEKFAQIAEDVGAYFMVDMAHIAGLVAAGLHPSPVPYAHFVTSTTHKTLRGPRGGFILCKKEFAKEIDKAVFPGIQGGPLMHVIAAKAVAFKEAMSPEFKEYQKQIVLNAKAMAEELIKLGYRLVSGGTDNHLMLVDLRDKGITGKEAEKALEEAGITVNKNAIPFDPQPPTITSGIRIGTPALTTRGMKEDEMRYIARLIHEVLSNFKDERVKEKVKKEVEELCKQFPIYRKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E042</accession>
    <name>B8E042_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transmembrane anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583209.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352739.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0844"/>
    <dbReference type="EnsemblBacteria" id="ACK42125">
        <property type="protein sequence ID" value="ACK42125"/>
        <property type="gene ID" value="Dtur_0844"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0844"/>
    <dbReference type="eggNOG" id="COG5660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1774434_0_0_0"/>
    <dbReference type="InParanoid" id="B8E042"/>
    <dbReference type="OMA" id="IHNIPEM"/>
    <dbReference type="OrthoDB" id="1779122at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="3"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="146" mass="17329" checksum="F2CFF15E0314D1EC" modified="2009-03-03" version="1">MRCKEVRRLLSAYIDGEVSPAKRMEIEEHLSYCLECKKELLTLEKLIKELHEIPEIIPSEDFSKRLWTKIALGDERNTSYINWRKIFIVLGTAAIFLGLIFVIQSYFNQFLSKQNNTYVYYELHGKMINSTFTRENNLVELVIFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E046</accession>
    <name>B8E046_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583213.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352743.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0848"/>
    <dbReference type="EnsemblBacteria" id="ACK42129">
        <property type="protein sequence ID" value="ACK42129"/>
        <property type="gene ID" value="Dtur_0848"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0848"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.887"/>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_3_0_0"/>
    <dbReference type="InParanoid" id="B8E046"/>
    <dbReference type="OMA" id="LFKNFAD"/>
    <dbReference type="OrthoDB" id="1594801at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="157" mass="17847" checksum="1339F87C30AAAF6E" modified="2009-03-03" version="1">MMVEVYVAGLSLDPQTNQFVVILREKSEGKRFLPIWIGPFEANAIAIALEKIDIGRPLTHDLMKNIIEALDAKVEKVFIHSLKENTFYATIYINIDDKTLEVDSRPSDAMALALRTNSPIYVDSKLIEEAGFVEEYSAEEELTKLLQDLNPDEFKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E055</accession>
    <name>B8E055_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="2">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0857</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583222.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352752.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0857"/>
    <dbReference type="CAZy" id="CBM61">
        <property type="family name" value="Carbohydrate-Binding Module Family 61"/>
    </dbReference>
    <dbReference type="CAZy" id="GH53">
        <property type="family name" value="Glycoside Hydrolase Family 53"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42138">
        <property type="protein sequence ID" value="ACK42138"/>
        <property type="gene ID" value="Dtur_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0857"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.896"/>
    <dbReference type="eggNOG" id="COG3867">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011259_1_2_0"/>
    <dbReference type="InParanoid" id="B8E055"/>
    <dbReference type="OMA" id="GIFYWEG"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011081">
        <property type="entry name" value="Big_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="PTHR34983"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07532">
        <property type="entry name" value="Big_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Big_4" evidence="4">
        <location>
            <begin position="403"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="3">
        <location>
            <begin position="473"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="619" mass="69690" checksum="FBE3D4591EB89408" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E066</accession>
    <name>B8E066_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="9" type="ordered locus">Dtur_0868</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583233.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352763.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0868"/>
    <dbReference type="MEROPS" id="M41.021"/>
    <dbReference type="EnsemblBacteria" id="ACK42149">
        <property type="protein sequence ID" value="ACK42149"/>
        <property type="gene ID" value="Dtur_0868"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0868"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.906"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_0"/>
    <dbReference type="InParanoid" id="B8E066"/>
    <dbReference type="OMA" id="YDKQGGG"/>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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</entry>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    <sequence length="265" mass="29872" checksum="57CF3E25FD305D47" modified="2009-03-03" version="1">MERKSIRMLTEGALSIALSLLLWYLRIGAMPQGGSISLQMLPLFIFALRWGFVPGLLVGVTYGLIHSLQDMYVVHWLQYLLDYPIAFGLIGLSGIVKNLKISKFITYIIAVLFLLGTIFFVVNISSELPQTQTTLEELKAKLQTATGEEKSKIEEDIKDLEFKIKWYPVSRIVLIIAGILGTLLLLYGGYIRKTQEPIELGVFIGGLGRLFAHFLSGIIFFSEYAPPGTPAWIYSLIYNLFVVVPSTFVCLPFVLIIMQRLRENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
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            <dbReference type="PubMed" id="28066333"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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            <end position="308"/>
        </location>
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        <source>
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    <sequence length="1017" mass="119113" checksum="FBF6A8D279C1CF72" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0G6</accession>
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        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
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        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1337</name>
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        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583692.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353225.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1337"/>
    <dbReference type="EnsemblBacteria" id="ACK42611">
        <property type="protein sequence ID" value="ACK42611"/>
        <property type="gene ID" value="Dtur_1337"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1337"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1382"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_0"/>
    <dbReference type="InParanoid" id="B8E0G6"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="204" mass="23640" checksum="141AFD698DC7E5EC" modified="2009-03-03" version="1">MDKFIILATKNEGKIREILDILSEYRSWIKTLKDLNLDIELPEELGESYEENAFIKARYIAELTGYPVIAEDSGLEIDALKGELGIHSARFGGSVGYKEKIRLVLEKMKDIPWEDRKARFVCKAVFYDEKEDIKIITGGKVEGYIAYEPRGERGFGYDPIFYFPPLGKTFGEINEFEKNKYSHRFMAFNKLKLFLECFYKGGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0I2</accession>
    <name>B8E0I2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine--scyllo-inositol transaminase</fullName>
            <ecNumber evidence="4">2.6.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1353</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.50" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583708.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353241.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1353"/>
    <dbReference type="EnsemblBacteria" id="ACK42627">
        <property type="protein sequence ID" value="ACK42627"/>
        <property type="gene ID" value="Dtur_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1353"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1398"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_6_0_0"/>
    <dbReference type="InParanoid" id="B8E0I2"/>
    <dbReference type="OMA" id="PGDAVFC"/>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047310">
        <property type="term" value="F:glutamine-scyllo-inositol transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080100">
        <property type="term" value="F:L-glutamine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="370" mass="42192" checksum="B29B3E26E3B1EE95" modified="2009-03-03" version="1">MRIPAFDLTRQYKRISNDLLPLLEQVLSKGQFILGENVHLLEQELADYCNVKYGLGVASGTDALLISLEALGVKEGDEVITTPFTFFATSEVISLLKAKPVFVDIDPTTYNIDPEKVEDAISPKTKGIIPVHLFGQMAEMDDLTYLAEKYDLFIVEDACQAIGAEYKGKKAGSIGNTGCFSFFPTKNLGGYGDGGFITTNDEKIYEKIKLLRVHGSSKKYYHDIIGHNSRLDEIQAVILRVKLKYLDSWIERRREIAKIYSENLKNFDIVVPEERPYLKHVYHQYVIRVKKRDELQNYLSSKGIGTAIYYPLPLHLQKCYEDLGYKKGDFPEAEKASEEVLALPMWPELTDEEVYYVIETVREFYDKYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0K6</accession>
    <name>B8E0K6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ordered locus">Dtur_1377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583730.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353265.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1377"/>
    <dbReference type="EnsemblBacteria" id="ACK42651">
        <property type="protein sequence ID" value="ACK42651"/>
        <property type="gene ID" value="Dtur_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1377"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1422"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_0"/>
    <dbReference type="InParanoid" id="B8E0K6"/>
    <dbReference type="OrthoDB" id="2034291at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="49" mass="6019" checksum="84898E21C9CCE40F" modified="2009-03-03" version="1">MRVIITLACTECKERNYTTEKNKKNDPDRLELRKYCPRCKKHTLHREVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0K7</accession>
    <name>B8E0K7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7 8">Elongation factor Tu</fullName>
            <shortName evidence="7">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tuf</name>
        <name evidence="10" type="ordered locus">Dtur_0979</name>
        <name evidence="11" type="ordered locus">Dtur_1378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2008-12" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Dictyoglomus turgidum DSM 6724.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Lucas S."/>
                <person name="Copeland A."/>
                <person name="Lapidus A."/>
                <person name="Glavina del Rio T."/>
                <person name="Tice H."/>
                <person name="Bruce D."/>
                <person name="Goodwin L."/>
                <person name="Pitluck S."/>
                <person name="Sims D."/>
                <person name="Brettin T."/>
                <person name="Detter J.C."/>
                <person name="Han C."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Hauser L."/>
                <person name="Kyrpides N."/>
                <person name="Mikhailova N."/>
                <person name="Mead D."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583343.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352873.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353266.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0979"/>
    <dbReference type="EnsemblBacteria" id="ACK42259">
        <property type="protein sequence ID" value="ACK42259"/>
        <property type="gene ID" value="Dtur_0979"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42652">
        <property type="protein sequence ID" value="ACK42652"/>
        <property type="gene ID" value="Dtur_1378"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0979"/>
    <dbReference type="KEGG" id="dtu:Dtur_1378"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1016"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_0"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="10"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="405" mass="44890" checksum="446EF7A227D22E90" modified="2009-03-03" version="1">MAKEKFVRTKPHVNIGTIGHVDHGKTTLTSAITMALAAEGLAKPLKYEDIDKAPEERARGVTINLAHVEYETPNRHYAHIDAPGHADYIKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVNVPYIVVFLNKIDMVDDPEIIDLVEMEVRDLLTKYGYPGDEVPVVRGSALKALEVLFQNPNTKRGENKWVDAIWELMDAVDNYIPIPERDVDKPFLMPIEDIFSITGRGTVVTGRVERGRVKVGDEVEIVGLSDEIKRSVVTGVEMFRKQLDEAIAGDNIGILLRGIDKDEVERGQVVAAPGTIKPHTHFKAQVYVLKKEEGGRHTPFFSGYKPQFYFRTTDVTGEIKLPEGVQMVMPGDNIEMEIKLIKPVALEEGLRFAIREGGRTVGAGVITKIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0L1</accession>
    <name>B8E0L1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584106.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353645.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1759"/>
    <dbReference type="EnsemblBacteria" id="ACK43031">
        <property type="protein sequence ID" value="ACK43031"/>
        <property type="gene ID" value="Dtur_1759"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1759"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_4_0"/>
    <dbReference type="InParanoid" id="B8E0L1"/>
    <dbReference type="OMA" id="NIERHIV"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902201">
        <property type="term" value="P:negative regulation of bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="131"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="266" mass="31054" checksum="073CCAF35CA59ADA" modified="2009-03-03" version="1">MEEFYQDFQIISREEAKEIIDILSFGNDNSFYTSKDIKLFAYNIPEDYLLIPLKRNEKLYGFVGLSMPSSYDLQDTILSILYHLTISLENSFIYEHTEKLSCIDPLTGVYNKRKIDEILENEINRALRYNRPLSLLFIDIDHFKNINDMYGHIIGDNFLKELALFLLRNTRNIDSIGRFGGEEFVCILPETDLDSAYKVGEKLRIRWNIERHIVPINVQEKTGTLSIGIANSPIHSQNPRELLILADNALYKAKRERNKTSIFEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0L2</accession>
    <name>B8E0L2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonyl/alanyl tRNA synthetase SAD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584107.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353646.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1760"/>
    <dbReference type="EnsemblBacteria" id="ACK43032">
        <property type="protein sequence ID" value="ACK43032"/>
        <property type="gene ID" value="Dtur_1760"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1760"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1812"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_7_2_0"/>
    <dbReference type="InParanoid" id="B8E0L2"/>
    <dbReference type="OMA" id="DREFKYD"/>
    <dbReference type="OrthoDB" id="783542at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106074">
        <property type="term" value="P:aminoacyl-tRNA metabolism involved in translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK43032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="383" mass="44792" checksum="DDBB4F29EE33E27A" modified="2009-03-03" version="1">MRTRKIYYEDSEIFNWKSRIEDIKQEGDFLLLSLDETIFYPEGGGQPSDRGEIVGEAWKLEVSKVFEKDGVIWHKGKIFGENFPKIGEIVDLFINIDLRREYMEQHTAQHLLSAILEKDYSLETTGFQVFEDHTKIEIPYKGLDPEGFIKEVEGKVNEYIGRNISISIYWKDESTRIVEIPGLDVNPCGGLHVKSLGELKLLKILDFYKKNNLYWRVEFVAGRRIIKQLEKREKEYKIIKEKLGNPNIVEGVDMLLSKADNLEKQIRKLKEELNSYRLEALLKETKEFKEYKFVARMMDLEIGDLKYVAQGLFVKDKVVGVLFNPQGQGFVFGRSVEKDLWNSILSFLFRNGWRGSKEGEFLQGKIENPKKVIEEIFLEFFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Q6</accession>
    <name>B8E0Q6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-glucan phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584150.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353690.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8E0Q6"/>
    <dbReference type="STRING" id="515635.Dtur_1805"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK43076">
        <property type="protein sequence ID" value="ACK43076"/>
        <property type="gene ID" value="Dtur_1805"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1805"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1857"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015112_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0Q6"/>
    <dbReference type="OMA" id="LYRHGYF"/>
    <dbReference type="OrthoDB" id="137158at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="570" mass="65381" checksum="4FDAF655085470EC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0S2</accession>
    <name>B8E0S2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="10">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="10">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pfp</name>
        <name evidence="12" type="ordered locus">Dtur_1385</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583737.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353273.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1385"/>
    <dbReference type="EnsemblBacteria" id="ACK42659">
        <property type="protein sequence ID" value="ACK42659"/>
        <property type="gene ID" value="Dtur_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1385"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1432"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0S2"/>
    <dbReference type="OMA" id="TNRDNPF"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="11">
        <location>
            <begin position="5"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="10">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="10">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="346" mass="37460" checksum="D90654D4E3BCA5CA" modified="2009-03-03" version="1">MSKMRIGVLTGGGDCPGLNPAIRGIVMRALDYGDEVIGLKYGWAGLIKADTMPLSLDIVEDILEVGGTILGSSRTNPFKKEEDVQKCIENFKKLNLDALIAIGGEDTLGVASKFSKLGLPMIGVPKTIDKDLEETDYTLGFDTAVEVVVDAIKRLRDTARSHARVIVVEIMGRHAGWLALYGGLAGGADYILIPEVEPNLEDLYNHIRKLYARGRNHAVVAIAEGVQLPGFTYQKGQEGMVDAFGHIRLGGVGNVLAEEIQKNLGIETRAVILSHLQRGGSPSIRDRIMGLLLGKKAVDLVHEGKSGLFVAVKGNDLVPVDITLIEGKTKNVDPEFYESVKTFFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0T3</accession>
    <name>B8E0T3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4 5">Acylphosphatase</fullName>
            <ecNumber evidence="3 4 5">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="3 4 5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583748.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353284.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1396"/>
    <dbReference type="EnsemblBacteria" id="ACK42670">
        <property type="protein sequence ID" value="ACK42670"/>
        <property type="gene ID" value="Dtur_1396"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1396"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1443"/>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_2_1_0"/>
    <dbReference type="InParanoid" id="B8E0T3"/>
    <dbReference type="OMA" id="VGFRWSM"/>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="90" mass="10502" checksum="A2DAF3E602C55BA0" modified="2009-03-03" version="1">MKKYIHAYISGIVQGVGFRYFAYKWAKRLGISGYVRNLRDGRVEVEAEGEEDVLREFIKKLEEGPLGAVVERVEVIWGECKNIFMDFEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0U7</accession>
    <name>B8E0U7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="16" type="ordered locus">Dtur_1410</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583762.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353298.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1410"/>
    <dbReference type="EnsemblBacteria" id="ACK42684">
        <property type="protein sequence ID" value="ACK42684"/>
        <property type="gene ID" value="Dtur_1410"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1410"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1457"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0U7"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031522">
        <property type="term" value="C:cell envelope Sec protein transport complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015462">
        <property type="term" value="F:ABC-type protein transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="15">
        <location>
            <begin position="1"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="86"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="413"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="102"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACK42684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="787" mass="91375" checksum="87D735AB26662E18" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0V0</accession>
    <name>B8E0V0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583765.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353301.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1413"/>
    <dbReference type="EnsemblBacteria" id="ACK42687">
        <property type="protein sequence ID" value="ACK42687"/>
        <property type="gene ID" value="Dtur_1413"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1413"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1460"/>
    <dbReference type="eggNOG" id="COG0381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0V0"/>
    <dbReference type="OMA" id="FWRRIPV"/>
    <dbReference type="OrthoDB" id="1117971at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="24"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="381" mass="43687" checksum="D13C40F1EC8D5205" modified="2009-03-03" version="1">MSKKKISLVFGTRPEAIKMAPVAKALKDSEFFEVQIILTAQHRELLDQVMEIFDLKGDYDLNIMQEKQTLTQITVKVLEGLDFIWQKDPPHMVLVHGDTTTTFSASLAAFYKKLPVGHVEAGLRTYDKYQPYPEEMNRHLTGVLADLHFAPTKKAKENLINERISEKNIFITGNTVIDTLLFVHKNMDKLKPSKLVEELPEKFILVTAHRRENWGEPLKNIVLALDEILRRFDDLYVVFPVHPNPIVKEQVYSILGKNKKAILIPPVDYITMVYLLDKCYLVLTDSGGLQEEAPSLGKPVLVLREVTERPEAVEAGTVKIVGTYKENIIKELRTLILDKEEYTRMSKAINPYGDGRASERIRDILLYYFGFRDFPPVEFNP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Y4</accession>
    <name>PLSX_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsX</name>
        <name type="ordered locus">Dtur_1447</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583799.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353335.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0Y4"/>
    <dbReference type="SMR" id="B8E0Y4"/>
    <dbReference type="STRING" id="515635.Dtur_1447"/>
    <dbReference type="EnsemblBacteria" id="ACK42721">
        <property type="protein sequence ID" value="ACK42721"/>
        <property type="gene ID" value="Dtur_1447"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1447"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1494"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_0"/>
    <dbReference type="InParanoid" id="B8E0Y4"/>
    <dbReference type="OMA" id="HGKSNAR"/>
    <dbReference type="OrthoDB" id="631784at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000116375" description="Phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <sequence length="336" mass="36749" checksum="E52292FD29E02539" modified="2009-03-03" version="1">MKIALDAMGGDYAPIETVKGALEAIKESNISVVLVGKEEEIKKILQDYHYNESKIEIVHAEEVIEMHEHPAFAVKEKEDSSIVKAIKLLKEKKVDGVVSAGNTGAVMSSALLYLGRIRGIKRPAISTLIPTLTQIPSIILDIGANVDCKKEYLEQFALMGKVYMEEIFNVKNPKIALLNIGEEEGKGNQLVQETYTLLKNNPLFNFIGNVEGKDLFKGTANVIVCDGFVGNVAIKTAEGVAETLFDLLSSEIKSSLWSIILGLLLKPKFKNVKKKLDYSEFGGAPLLGVDGTVIISHGRSKAKAIKNALKVAEKMVKLEVNKKILEGLNKITDRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E117</accession>
    <name>B8E117_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATPase AAA-2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583832.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353368.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1480"/>
    <dbReference type="EnsemblBacteria" id="ACK42754">
        <property type="protein sequence ID" value="ACK42754"/>
        <property type="gene ID" value="Dtur_1480"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1480"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1529"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_0"/>
    <dbReference type="InParanoid" id="B8E117"/>
    <dbReference type="OMA" id="ERMKAVM"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="2"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="428"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="823" mass="93576" checksum="14C7C3AB5BDC3865" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E124</accession>
    <name>B8E124_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent hydrolase of the metallo-beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583839.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353375.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1487"/>
    <dbReference type="EnsemblBacteria" id="ACK42761">
        <property type="protein sequence ID" value="ACK42761"/>
        <property type="gene ID" value="Dtur_1487"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1487"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_3_0_0"/>
    <dbReference type="InParanoid" id="B8E124"/>
    <dbReference type="OMA" id="HFDHNAV"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="212" mass="23959" checksum="4A40BAA816FD44DD" modified="2009-03-03" version="1">MKIRWYGHACFLFTNSEGKKILTDPFDSSVGYPLPDVEPNIVTVSHEHFDHNAVHLLKGNPILVQGEGETQINSVKIKGLNTFHDEERGKKRGTNTIYLIETDGIKILHLGDLGHILTDEYKEKIGEVNILCIPVGGTFTIDANGAVKVVELLKPNVVIPMHYKTPHLKFDLAKVEDFINKVNYPVKKFEEKEIEINKDTLPPSTEVWILSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E173</accession>
    <name>B8E173_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Xylulose kinase</fullName>
            <shortName evidence="3 4">Xylulokinase</shortName>
            <ecNumber evidence="3 4">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">xylB</name>
        <name evidence="7" type="ordered locus">Dtur_0920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="3 4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352815.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0920"/>
    <dbReference type="EnsemblBacteria" id="ACK42201">
        <property type="protein sequence ID" value="ACK42201"/>
        <property type="gene ID" value="Dtur_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0920"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.957"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_0"/>
    <dbReference type="InParanoid" id="B8E173"/>
    <dbReference type="OMA" id="WHVMGVT"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005998">
        <property type="term" value="P:xylulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02220">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006000">
        <property type="entry name" value="Xylulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01312">
        <property type="entry name" value="XylB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3 4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="FGGY_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="6">
        <location>
            <begin position="259"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="82"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="site" description="Important for activity" evidence="3">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="518" mass="57387" checksum="BA9D4505D7769088" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E191</accession>
    <name>ACKA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetate kinase</fullName>
            <ecNumber evidence="1">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ackA</name>
        <name type="ordered locus">Dtur_0938</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583303.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352833.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E191"/>
    <dbReference type="SMR" id="B8E191"/>
    <dbReference type="STRING" id="515635.Dtur_0938"/>
    <dbReference type="PRIDE" id="B8E191"/>
    <dbReference type="EnsemblBacteria" id="ACK42219">
        <property type="protein sequence ID" value="ACK42219"/>
        <property type="gene ID" value="Dtur_0938"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0938"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.975"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_0"/>
    <dbReference type="InParanoid" id="B8E191"/>
    <dbReference type="OMA" id="KIITCHI"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000116390" description="Acetate kinase">
        <location>
            <begin position="1"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <sequence length="405" mass="44897" checksum="437614EC35A70730" modified="2009-03-03" version="1">MKVLVLNCGSSSVKYQVFDMKNESVLAKGLAERIGLEGSRIVYQRGSEAKKVFEIPLPTHKKAIEEIFKLLVDKNNGVLQSLNEIDAVGHRVVHGGDKFVESVLVNDEVYSIFKGILDLAPLHNPYNLQGVDACSELMPGVPQVLVFDTSFHQTMPEEAYIYALPYEWYEKYKIRRYGFHGTSHYYVSRRVAELIGRPVEELKIISCHLGNGASITAIKNGKSIDTSMGYTPLEGLVMGTRCGDIDPAIPILLMEKENLTPKQMDEILNKKSGILGISGVSSDFRDVGEAAEKGNKRAELALKVFAYRVKKYIGAYYAILGGLDVLVFTAGVGERGPLERSLICSGLEHLGIKLDPEKNKVKGEELRISAPDSKVEVWVIPTNEELMIARETVRVVGEKIIKKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1B2</accession>
    <name>B8E1B2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583324.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352854.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0960"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42240">
        <property type="protein sequence ID" value="ACK42240"/>
        <property type="gene ID" value="Dtur_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0960"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055069_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1B2"/>
    <dbReference type="OMA" id="THEENEG"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="158"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="345" mass="39331" checksum="E2F71E73DF3BD9CE" modified="2009-03-03" version="1">MEKKIKVNLIFKPGIPSSREKGGGDQTACKMLYEALKRRNDIEVYYNGTLKEGPYDILHFHSLGDIFFRYVKQSNKSKIVFTAHVIADTMLGSAILAEKWKSIFAQYLLLFYNQADVVIAVSPLEVEKLKEMGVKTEIVFIPNGIDLSMFKKDEDLRREMRKKFNLSDEDIVLLSVGHIIKRKGFDTFVKAAESLPQYKFLWVGGVPFSFLSGGYAEIKKILKNPPSNLILPGPSPHEELNKFYNMADIFFFPSRQENFSIAVLEASAVGLPLLLRDLEEYKAPLAPNYIPWNENDVIKKIVQLAENKDLREEYSKRAVVIAETYNIEKTTEATVNLYKKLLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1H0</accession>
    <name>B8E1H0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582580.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352109.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0164"/>
    <dbReference type="EnsemblBacteria" id="ACK41495">
        <property type="protein sequence ID" value="ACK41495"/>
        <property type="gene ID" value="Dtur_0164"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0164"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.170"/>
    <dbReference type="eggNOG" id="COG4370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035659_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1H0"/>
    <dbReference type="OMA" id="SGGFIYM"/>
    <dbReference type="OrthoDB" id="368220at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019994">
        <property type="entry name" value="CHP03492"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39517">
        <property type="entry name" value="PTHR39517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03492">
        <property type="entry name" value="TIGR03492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="404" mass="45868" checksum="6EE66C352B31B631" modified="2009-03-03" version="1">MKRILFISNGYGEDYVAVNVAKEILNMEPSISIEGLPIVGEGNLYINSQIPIIGPHKFTPSGGFLSSIRTLVKDVREGLIKLHYKQLKSLKEWLKEDGIIIAVGDIVPLALAVFSKKPFFFISIQKSVYYVINNNYENIEKKEAIKIAKKAYLLEYYFMKNNRLLKVFPRDKLSYDILKLSHINAEYLGNPMMDGLEPTGRLNLDKFENYLKVLLLPGSRIPEAYNNFNIILNGIFSLVHSDIKERFLFLTALAKSINMSEVSKILDEKNFTHIDSSEDYMLYNYKNHFLLLTNLFNDCIHQAQIGICMAGTATEQFVGLGKPVIVIPGKGPQYTKKFAYAQKRLLGPSLFIAENPKTLPNVFKKIYKNEKILKEVHENGKRRMGEKGASQKIAESIIKTIKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1J0</accession>
    <name>B8E1J0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0186</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582600.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352129.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0186"/>
    <dbReference type="EnsemblBacteria" id="ACK41515">
        <property type="protein sequence ID" value="ACK41515"/>
        <property type="gene ID" value="Dtur_0186"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0186"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.192"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1J0"/>
    <dbReference type="OMA" id="IRVGHAS"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="112"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="235"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="477" mass="53203" checksum="BF1B65C0EAA8F525" modified="2009-03-03" version="1">MLEIGREILNYASRLGGDYVDVRIVRRKQEEIEVKNGVLENASKNETYGFGVRVLYNGAWGFASSFNLSDYRKIVEKAFQIAKASASVNKKKVVLAPEEVYKAKWESQYKIDPFSVPFEKKLDLLFTADKIMREVKGISLTEASLSFFKEDKVFLSSEGSEIEQSILESGGGITAYAIEGADVQRRSYPNSFGGDFRKGGWEFIEELDLIGNAEKIAKEAVLLLSAEPLPEMVTTLILDGTQLALQVHESCGHPTELDRVLGMEASFAGTSFLTIDKRNNFQYGSEIVNIVADATHLYGLGSFGFDDEGVPAQKNYLVKNGLFVGYLTSRETAALFGEKSNGTMRADGWNRIPLIRMTNINLLPGDMPYEDLIASTDEGVYMAVNRNWSIDDKRLNFHFGCEIAYEIKDGKLGKIYKNPYYTGITYEFWRSCDAIADEKSWRVWGVPNCGKGEPMQVARVGHGVAPARFKKVKVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1K0</accession>
    <name>B8E1K0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbohydrate kinase FGGY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582610.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352139.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0196"/>
    <dbReference type="EnsemblBacteria" id="ACK41525">
        <property type="protein sequence ID" value="ACK41525"/>
        <property type="gene ID" value="Dtur_0196"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0196"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.202"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_3_0_0"/>
    <dbReference type="InParanoid" id="B8E1K0"/>
    <dbReference type="OMA" id="SDAMHFK"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="262"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="496" mass="55753" checksum="60192FF38632BFAD" modified="2009-03-03" version="1">MDKEKLVLAVDLGTTNIKSGIINKKGKILSLIQKELPLEKDNTGKAEHAPEVIFNIFVETIRETTKGYEDKIGILITSSYMFGVLPLDKNMKPLTGIITLLDTRTKEIFNELLKEVDFKEVYKRTGCPPLLYYPFVRIYWLKKKHKEIFDSAKFYLGSKSFLIYKLMGELYTEPSIDSSTQLLNIHTLNWDPYVLDFLGISYENLPQVVSADKILGKLPKSTLNLLGLKGEVLLGVGLYDGGAVGSGIGALGGDGIGVINIGTTAMFRVPYPKVVFDDPQKMRIQVPYFFDGKWFPGGGINNAGIILKWYRDNLFNLSYEEQSKIAKDIESDNLFFLPYLTGERNPDIGSIASGVLFGLRPHHTKAHIVRAGMEGVSYIIRMLYETLRELGIEVKEVRAGGGGTKSDTWMQILADIMGLEVAVTRVEEPALLGSAVLGFTMLGEFSSYKEATEKLVKIEKVYSPNKEKKEYYNKKFEFFVQLTHNLKEAFSMHNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1N3</accession>
    <name>B8E1N3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582643.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352172.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0229"/>
    <dbReference type="EnsemblBacteria" id="ACK41558">
        <property type="protein sequence ID" value="ACK41558"/>
        <property type="gene ID" value="Dtur_0229"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0229"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.239"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084683_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1N3"/>
    <dbReference type="OMA" id="AYKVVIS"/>
    <dbReference type="OrthoDB" id="1687022at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="151"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="285" mass="32435" checksum="32867A633A1446D2" modified="2009-03-03" version="1">MIMAYLFLLGRIILLGYEKIVVKKVGDKSNSIATSFLFFLTATLFLLPFAFGKNVSLDFGRLRYGILSGFIYSISFVLYVKSLSLGEASLVGPLYNFNVFFLLILTTVFLREPFTLQKIVGLSLLVYGASFLSKQENLFKSLRVLFEKKETLFMLGSSFLIAIGRTIDGFVVGKVDPLFYCFFLYFVISIYQFIYILLRKELGEVLKIFKEKALLVFIAGAINAYSYLFLLIAFKSIDVSIAEPLSMLSMIITLILAKNIFKENIRERTIGVLIMILGAWILNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1P2</accession>
    <name>B8E1P2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352181.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0241"/>
    <dbReference type="EnsemblBacteria" id="ACK41567">
        <property type="protein sequence ID" value="ACK41567"/>
        <property type="gene ID" value="Dtur_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0241"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.252"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_607980_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1P2"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902201">
        <property type="term" value="P:negative regulation of bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="315"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="450" mass="52402" checksum="BE3BD6DD6AA23958" modified="2009-03-03" version="1">MPYVRQAIISALNSIGHPSMPERIKKLLKSENPYERESAVKIAGYFGYEECKEEIFNLVNDKDEEVRKVAYENIVFFEDEKIFEILKEGLEKEKRKVREVIARSLIYLGKDKALPLVEIALRDSSPWVRYYGVKSLIHHNPPDLLSILQDLLSKEDTTLVKIIIIESIGKTGNVKAIDILKMLMDTNDKDLLLAEQSLVGLKTFNDFLNYIYEEDRERFKQRYHELLDKTFEYIIDEFKIKKGKDIAYIEMSMVGIMYKGKPAILGTTLDITYRKKMEEELKILSITDPLTGLYNRRGFITLADHTLNLVKRLNKKAIILFIDLDYMKWINDNLGHNVGDQALIDVANILTSTFRQNDLIARIGGDEFVVLGIIGEENHKEKIIERLTEKVKEFNTKEKRPYKLSLSVGYVVYDPENPKTLEELLQLADQLMYEEKRLKKQNSQYPFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1T7</accession>
    <name>B8E1T7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide-transporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582805.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352334.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0416"/>
    <dbReference type="EnsemblBacteria" id="ACK41720">
        <property type="protein sequence ID" value="ACK41720"/>
        <property type="gene ID" value="Dtur_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0416"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1T7"/>
    <dbReference type="OMA" id="VWNGFLV"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="335" mass="36385" checksum="7195A296DD3F6298" modified="2009-03-03" version="1">MAKMGSINGLREKSYDIAKLREIGIIFPLFLFGLIIALRNPYFISWENLRYIFLDASILTIVAIGEMMVILTGGIDLSVGSNLALTGMTVSMIYRDFHNFPVILAPLIGILIGGVCGAINGLFVAKGKVIPIIATLSTMYIFRGIVYIISGGRWVNAHEMPEGYKLLTRVEILGIPILVIYALIVFLFFYYLLNYKAIGRSIYAVGNNPQSAIYIGINKVKVLFLVYLISGILAGLSGVLYTSRFASAESSAAIGFELSAISAVVIGGVKTTGGSGKIGGVVLGALLLTMIVNGLNVMKISPFYKLALQGLMFLIAVIVDSLIAERYYKGRRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1T9</accession>
    <name>B8E1T9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582807.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352336.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0418"/>
    <dbReference type="EnsemblBacteria" id="ACK41722">
        <property type="protein sequence ID" value="ACK41722"/>
        <property type="gene ID" value="Dtur_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0418"/>
    <dbReference type="eggNOG" id="COG4288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143451_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1T9"/>
    <dbReference type="OMA" id="IVQYSRL"/>
    <dbReference type="OrthoDB" id="1610488at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.290.11">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009794">
        <property type="entry name" value="DUF1362"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036698">
        <property type="entry name" value="TM1070-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07100">
        <property type="entry name" value="ASRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008711">
        <property type="entry name" value="UCP008711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89232">
        <property type="entry name" value="SSF89232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="124" mass="14328" checksum="1ED6D72C6A3FEEC0" modified="2009-03-03" version="1">MNKEIGAKIWLIPDAYLPEIGDPNLPSHESTCILNVNDKPAKVKFTFYFEDRDPIESKEIIVLPERTWHVRLDKSEEILGVKLERNVPFAIKVESDVKIVVQHSRLDTRQPNLSYMTAIAWNVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1W0</accession>
    <name>B8E1W0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582828.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352357.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0441"/>
    <dbReference type="EnsemblBacteria" id="ACK41743">
        <property type="protein sequence ID" value="ACK41743"/>
        <property type="gene ID" value="Dtur_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0441"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.466"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035227_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1W0"/>
    <dbReference type="OMA" id="GREMSEY"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="378" mass="41855" checksum="9DA3E2190A516378" modified="2009-03-03" version="1">MRKVLIFLFLVSLTFTPIFSQDKFLGGWEKVYGGPKSEKGYGIVKVEDGYLLGGETTSLGSGGKDIYLLKIDKEGNKVFEKAIGGPKDDYSFSMIEGKDGYFIVGATRSFGAGNSDVYVVKVNGNGDILWQKTYGGRGFEEGWRIVKDNEGNYIIVGRTNSFGSGQYDLYLIKIDENGNLLWERAYGREMSEYGYGVCNDEDGYVAVGITNSFSEGQDIYVIKVDKNGNLLWEKIYGGKGYDYAYDITNGDDGYLIVGNSNSFSDSVDLYVLKTNKNGDKVWEKTYGGKGYDTGFSVLRTDTKYLIVGGSNSQGAGNSDLYVVKLDEKGNLIWEKYFGGADLDEGWGLVLENSWFIAIGRSESFSTANSELYVVKFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1W3</accession>
    <name>B8E1W3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0444</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582831.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352360.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0444"/>
    <dbReference type="EnsemblBacteria" id="ACK41746">
        <property type="protein sequence ID" value="ACK41746"/>
        <property type="gene ID" value="Dtur_0444"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0444"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.469"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_4_3_0"/>
    <dbReference type="InParanoid" id="B8E1W3"/>
    <dbReference type="OMA" id="MVPCVEE"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="390" mass="42870" checksum="7F0561E625B07869" modified="2009-03-03" version="1">MDLSCSYVGLRLKNPIIIASSGLTENLKNMKKCEENGAGALVVKSLFEEEICRVSPTPRFEIISRSMGPLRSQTFYSFEQASPFEPEEYFKEISKALSVLSIPVIPSINCITDDGWLKYSKMAEEVGAPALELNVSCPHASISFRGQDVDETILHVARIVRENVKIPIVVKLPMQLSSPLAVAKALENIGVDGVVMFNRLTGLDINLDTEKPILHGGYAGHGGPWAFNYVLRWISTSRPHLKLSIAGSGGVGSGDDVAKYILTGADVVQICSIVYLMGYEIIPRIIDGLKKFMENKKYSTLSDFRGKVSGKVILGNYEIDRRHLYEAYINSDLCTSCGICKKVCIYDAPIEKDGKYFITDLCDGCGLCVRLCPTKAISMVFVGGRENAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1X9</accession>
    <name>B8E1X9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582847.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352376.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8E1X9"/>
    <dbReference type="STRING" id="515635.Dtur_0462"/>
    <dbReference type="CAZy" id="GH1">
        <property type="family name" value="Glycoside Hydrolase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41762">
        <property type="protein sequence ID" value="ACK41762"/>
        <property type="gene ID" value="Dtur_0462"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0462"/>
    <dbReference type="eggNOG" id="COG2723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001859_1_3_0"/>
    <dbReference type="InParanoid" id="B8E1X9"/>
    <dbReference type="OMA" id="DWVYVVP"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018120">
        <property type="entry name" value="Glyco_hydro_1_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="PTHR10353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00572">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="418" mass="49550" checksum="C917A95B14C3CEC1" modified="2009-03-03" version="1">MVKYKFPEGFLWGTATASHQIEGDNFYNDWWEFEKQGKVKNGQVSGKACDSWNRYEEDFDLIEKLNNNAYRFSIEWSRIEPEEGRFDESALERYRSMLISLRRRNIEPFVTLHHFTNPLWMAKRGGWLNPDIIDYYLRYVKKIVSEFKDLVNYWMTINEPNAYAFMAYLYGQFPPQGKSLIKMLRVLNNMAKAHAKAYEVIHQISPDAKVSIAYNVIYFEPKNPNSFIDRKFANFGDRIYNRVFIETLLTGKFSSPFIKEEIPYAKNTLDYLGINYYTRILMGLKMGSPEGETSDFGWEIYPEGIYKVVKRFYGLTKKPIYITENGISDAKDEKRPKYLISHLIQLHRAIEEGVDVRGYFHWSLMDNFEWAEGFLQRFGLFETDFNTFERKWRESARIYSEIAKNNGITEAMEEKFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E216</accession>
    <name>B8E216_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582884.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352413.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0506"/>
    <dbReference type="EnsemblBacteria" id="ACK41799">
        <property type="protein sequence ID" value="ACK41799"/>
        <property type="gene ID" value="Dtur_0506"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0506"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.537"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="InParanoid" id="B8E216"/>
    <dbReference type="OMA" id="IAFFIAW"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="271" mass="30695" checksum="246728E4C8D38BFB" modified="2009-03-03" version="1">MKRLKTSTIFTYLFLIIVSFISLFPFIWMIIGTTNKSVDILRGKFTFGNNLLENFQNLLASYNLGKILINSLKISLIVTVGALLISSLAAYGFEIYASNIREKIYSIILGTLMIPFAALMVPLFKLMTSFNLIDSHWGVILPMLSSVFLIFFFRQNFKMYPKEIIMAARVDGANELQIFFSIVFPSMRSAYAAGAIWAFMNSWNSYLWPLVILQSEEKKTMTLLISTLASGYTPDFGVIMTAVVIATLPMIIVFFTLQNYFIQSILGSMKQ</sequence>
</entry>
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
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    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1036"/>
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    <dbReference type="EnsemblBacteria" id="ACK42316">
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        <property type="gene ID" value="Dtur_1036"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1036"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1073"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_0"/>
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    </dbReference>
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        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:transition metal ion binding"/>
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        <property type="project" value="UniProt"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
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        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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            <begin position="2"/>
            <end position="128"/>
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            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="354" mass="40105" checksum="CFBF7C198BC3303E" modified="2009-03-03" version="1">MIEKIQERLKKEDIDAIWISNIINIRYLTGFTGSTADLLVLKEGGYILVDSRYWEQVNHEVRKVKPILVDGDLNLFTFLKELENKDGLKKIGFESSNVVYSTWVKLRELLQNIELIPLSHWVEELRMVKTEDEIEKIKKALMIAEQAFEKILPLIKVGITEKDIAIELEYQMAKLGSERPAFDTIVASGERGALPHGKASNKKLMGNEFIVFDFGAVYEGYHSDITRTIYFGNPGEEEILIYNIVLEAQKKAEEVIEEGIQCNFVDKVARDIIQENGFGNYFGHGLGHGVGLEIHELPRVSPKSETVLKKGMVITVEPGIYIPGKFGIRVEDMVVVDSHCSKILNKLTNDLIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E261</accession>
    <name>B8E261_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
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    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_002352952.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1058"/>
    <dbReference type="EnsemblBacteria" id="ACK42338">
        <property type="protein sequence ID" value="ACK42338"/>
        <property type="gene ID" value="Dtur_1058"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1058"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_0_0_0"/>
    <dbReference type="InParanoid" id="B8E261"/>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="Proteomes" id="UP000007719">
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    </dbReference>
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        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
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    </dbReference>
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        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="281" mass="31753" checksum="D75BA39A5444C842" modified="2009-03-03" version="1">MIIGIVGLGLIGTSLALSLKKGFGDLYLWGVDNDCEVLGYLSEKKIFDVLEKRLDRFKDLIRETDCVFISVHPSSVMDVVKNIESYVKEGVIITDTASTKSKIMSYVNNDEFLRKIFIGGHPLAGREISGPLGAVDNLFDGKIYFLCPAIEVSKEKIGSLEKLLKKINATPLIIDPEVHDEILAFTSHLPQIIAYLLSYVAINENNIDFFGSGFKDITRIAKSDYNLWVDIVKENNIKIKKALGEFEKTLRDLVEKLEKEDFVSIEKLFKESKEKRLKLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E284</accession>
    <name>B8E284_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">Dtur_1082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583444.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352975.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1082"/>
    <dbReference type="EnsemblBacteria" id="ACK42361">
        <property type="protein sequence ID" value="ACK42361"/>
        <property type="gene ID" value="Dtur_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1082"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1118"/>
    <dbReference type="eggNOG" id="COG1801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046519_0_1_0"/>
    <dbReference type="InParanoid" id="B8E284"/>
    <dbReference type="OMA" id="YLRMHGR"/>
    <dbReference type="OrthoDB" id="1068600at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="228" mass="27730" checksum="88B7CF85F5C50986" modified="2009-03-03" version="1">MEIFIGTSGWSYSWNPKRDLGWYIENTPFNAIEVNSSFYHFPREKTILRWVKYGNKLRFVIKVHRSITHLYKFNEDAKENWIRFYNLFKTLEPFIELYLFQIPPSMSSENISKLIDFHRFTQLGDKFAFEPRRADWFYESILEKMKENNITFVSVSAPKLPDKIIVTTKKAYIRFHGKDRWYSYKYNEDELREYVERIKKLNADKVYIFFNNDYMLENGIVMYKLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E288</accession>
    <name>B8E288_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583448.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352979.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1086"/>
    <dbReference type="EnsemblBacteria" id="ACK42365">
        <property type="protein sequence ID" value="ACK42365"/>
        <property type="gene ID" value="Dtur_1086"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1086"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_1_1_0"/>
    <dbReference type="InParanoid" id="B8E288"/>
    <dbReference type="OMA" id="DILYHGP"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="180" mass="20532" checksum="E26449B54E94E0CE" modified="2009-03-03" version="1">MRILVMSDTHGDTTFWEYIKELLEKSDYVIHAGDVLYHGPRNPLPAGYNPPKLAELINNSKPFFIAKGNCDADVDQLVLNYPIASPYVFLHFEPFKILVTHGEDKREEDLWDMAEKYNVDILIFGHIHTPILKKENNRIILNPGSPSLSKTPNKTVALLQDNKIAIIDITDKTELYSLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>B8E292</accession>
    <name>B8E292_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">valS</name>
        <name evidence="13" type="ordered locus">Dtur_1090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583452.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352983.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1090"/>
    <dbReference type="EnsemblBacteria" id="ACK42369">
        <property type="protein sequence ID" value="ACK42369"/>
        <property type="gene ID" value="Dtur_1090"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1090"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1126"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_0"/>
    <dbReference type="InParanoid" id="B8E292"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="17"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="610"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="816"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="814"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="881" mass="104084" checksum="A23BED459E33F20D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2A7</accession>
    <name>B8E2A7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase III, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583467.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352998.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1105"/>
    <dbReference type="EnsemblBacteria" id="ACK42384">
        <property type="protein sequence ID" value="ACK42384"/>
        <property type="gene ID" value="Dtur_1105"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1105"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044694_2_2_0"/>
    <dbReference type="InParanoid" id="B8E2A7"/>
    <dbReference type="OMA" id="EEPYYID"/>
    <dbReference type="OrthoDB" id="1199768at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="1">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="328" mass="38423" checksum="3F4BA7C37AD77C75" modified="2009-03-03" version="1">MNYWEFKHSIKEKKFSPVYLFTGEEKFLMEEALEELKKARFKNANYVAFFADEISWDNLVPYLESPSLLGDQLIVIRHAQELKDQNMPKKLDLLFKRLTNTCIVFMANAEEEKAKRMSYAKYIPPEGLVEFTKFRADALRRWIKEKFQEKGKSIDEESIYFLSINYADKIGILMQEIEKICAFVGERNEVTIEDLKKVLATQEVAFYTFLDALLRRDFLIAFSGIDALWSEGVYPQVILEIVIKQIRQLLRINALLKDGYSSDEIKEKLGLHPFVVKKSIEALTKYTAAELMEIYFLLRQVDMDYKTTSKDQRILIEKVILKLGRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2C6</accession>
    <name>B8E2C6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="8">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="8">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">ImGP synthase subunit HisH</fullName>
            <shortName evidence="8">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hisH</name>
        <name evidence="11" type="ordered locus">Dtur_1124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="8"/>
    <dbReference type="EC" id="3.5.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583486.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353017.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1124"/>
    <dbReference type="EnsemblBacteria" id="ACK42403">
        <property type="protein sequence ID" value="ACK42403"/>
        <property type="gene ID" value="Dtur_1124"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1124"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1161"/>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_2_2_0"/>
    <dbReference type="InParanoid" id="B8E2C6"/>
    <dbReference type="OMA" id="WVYFVHS"/>
    <dbReference type="OrthoDB" id="1726024at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="8 9">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000495-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="202" mass="23084" checksum="250C89404A6F6965" modified="2009-03-03" version="1">MVKALIVDYAAGNLFSIIKAFKYIGIDPIVSNNPKDWEKADLLVFPGQGNFSQAMLNLRNEEKDAIFRELLRKKPFLGICLGMQILFEESEEAPGVPGFGLFKGKVKKIPVNKIPHLGWNEVDLKRESTFFKNIPNRSFFYFVHSYYVDTKEDIIYGFTEYGIAFPSFIVKDNIIGVQFHPEKSSDKGVKFLSNVLEEIQKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2D5</accession>
    <name>B8E2D5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">H+transporting two-sector ATPase C subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583857.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353393.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1505"/>
    <dbReference type="EnsemblBacteria" id="ACK42779">
        <property type="protein sequence ID" value="ACK42779"/>
        <property type="gene ID" value="Dtur_1505"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1505"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1554"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126047_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2D5"/>
    <dbReference type="OMA" id="IGAWKKC"/>
    <dbReference type="OrthoDB" id="1950613at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="6">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="157" mass="15855" checksum="C37BD1A32E43F98E" modified="2009-03-03" version="1">MLGLAIALIGAALGAGFAAAGSGKGVGIAGEAAAGVLAEKPDLFGTVLILQALPGTQGFYGFIGAFLILMRLGLLGGNVPNLTLEQGLMVFAVGIPLMIGEYVSAIWQGRASAAALQMVAQKPQTSGQAIIIPALVETYAILSLITSIILLFFGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2E6</accession>
    <name>B8E2E6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">Dtur_1516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583866.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353404.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1516"/>
    <dbReference type="EnsemblBacteria" id="ACK42790">
        <property type="protein sequence ID" value="ACK42790"/>
        <property type="gene ID" value="Dtur_1516"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1516"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1565"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_0"/>
    <dbReference type="InParanoid" id="B8E2E6"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="21"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="125" mass="14028" checksum="063BB8668C726E60" modified="2009-03-03" version="1">MYPEDRKYSKDHEWAKIEGNVAIIGITYHAQEELGDIVHVDLPEVGKEVKQNEVLAVIESVKSASDVYSPLSGKVIEINESLKGKPELINEDPYNAGWLVKLEVSDPKEYEGLLSAEEYKKLIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2I1</accession>
    <name>B8E2I1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_1551</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583900.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353439.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1551"/>
    <dbReference type="EnsemblBacteria" id="ACK42825">
        <property type="protein sequence ID" value="ACK42825"/>
        <property type="gene ID" value="Dtur_1551"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1551"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_2_1_0"/>
    <dbReference type="InParanoid" id="B8E2I1"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 9 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="10">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="11">
        <location>
            <begin position="134"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="12">
        <location>
            <begin position="245"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="367" mass="41188" checksum="C223250046C478F3" modified="2009-03-03" version="1">MKFITQQEDLYKSLQFVKSAVATKTTIPILTYVYMKAENDTLYLQGNNLEIGLALSMPVIVEEPGEVCLPASLFIDVIGKLPEVTLEIHVNERNRAVIHAGYSDIEIQGESTEEFPKVEIGNIGEYHASFDRILFAKAIKQTIFAAAEDEIKQVLTGVLFEGKEGKLNMVAVDGHRLALKTLEIEKDFAPIIVPSKSLKEWQKIITKAMDDRVNMAALDNQVVFNCGEIYFISRLLQGQFPAYDKIIPTDFTASFKANRKDFLDVLGRMEVFAEIDQTNTVKISLSSEEVVISTLPSERGFAKEVLPAEVEIDGNLEIGFNVEYLMDPLDNADWDEVVMRFTSDLGPALITSPEDENYTYILMPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2I6</accession>
    <name>B8E2I6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583905.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353444.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1556"/>
    <dbReference type="EnsemblBacteria" id="ACK42830">
        <property type="protein sequence ID" value="ACK42830"/>
        <property type="gene ID" value="Dtur_1556"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1556"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053649_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2I6"/>
    <dbReference type="OMA" id="AWEKNWG"/>
    <dbReference type="OrthoDB" id="884913at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039968">
        <property type="entry name" value="YghO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41368">
        <property type="entry name" value="PTHR41368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="375" mass="43674" checksum="1BBE198FD881A3D5" modified="2009-03-03" version="1">MTREIREVKTEKEKKDFIMLPFELYKNDPHWVPPLISEMKRIINGSGSLLFQSGPYALFNAYENGKVVGRIAVGIDEKMNRLRNKTEGYITLFESINSKEVAFSLLDTAQNWLKERNMTKMVGPVSPTNGDDYRGMLVENFEDPPVIYTTYNPPYYVDFFKEYGFEPEHTFVAFKYDLKRLPLDESIRVIEYAKKRYNFYTRKADYSKIPDEARILQKILERSLIPLEYDYLIPPTEEEMLTLAKDLVKFIPAEFVQLAFSGESPVGFAVAMPDYNQVLKRLNGRLFPLGWLKFLWYKNKINKARVFLLFVIPEFQSKGVPAALFIELLRYAREKGYVFAEGSTININNTKMCREAEGVGGVLYKKFVIFKKEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2S9</accession>
    <name>B8E2S9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ordered locus">Dtur_1150</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583511.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353043.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1150"/>
    <dbReference type="EnsemblBacteria" id="ACK42429">
        <property type="protein sequence ID" value="ACK42429"/>
        <property type="gene ID" value="Dtur_1150"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1150"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1187"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_1_0"/>
    <dbReference type="InParanoid" id="B8E2S9"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="359"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="548" mass="60769" checksum="56746AA44B51A3FE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2T0</accession>
    <name>B8E2T0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell divisionFtsK/SpoIIIE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583512.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353044.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1151"/>
    <dbReference type="EnsemblBacteria" id="ACK42430">
        <property type="protein sequence ID" value="ACK42430"/>
        <property type="gene ID" value="Dtur_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1151"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1188"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_9_7_0"/>
    <dbReference type="InParanoid" id="B8E2T0"/>
    <dbReference type="OMA" id="RDPENHH"/>
    <dbReference type="OrthoDB" id="349533at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="6">
        <location>
            <begin position="315"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="333"/>
            <end position="340"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="646" mass="73143" checksum="3487BAD4F2D78FE0" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2T6</accession>
    <name>B8E2T6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="2">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583518.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353050.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1157"/>
    <dbReference type="EnsemblBacteria" id="ACK42436">
        <property type="protein sequence ID" value="ACK42436"/>
        <property type="gene ID" value="Dtur_1157"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1157"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1194"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_5_0"/>
    <dbReference type="InParanoid" id="B8E2T6"/>
    <dbReference type="OMA" id="GASPMEF"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="4">
        <location>
            <begin position="43"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="211" mass="24530" checksum="FB0C0EF8BB5AC83A" modified="2009-03-03" version="1">MRQIRKSISHFFYKILIVVVRFLLNILWGYKVEGKENIPNHSFILVANHVSILDPIVIGAAFDKRLFYLAKKELFKSKIFNPFLRWLGAIDVDRKDFKYETWKKINRLIKENEIIVIFPEGTRNDHPEKGLLELKDGAASLALTHGLPILPVAIKGTEKIWKRKWIFPQLRGRINIRIGKVINVSKIKKPSKEDIKEVNNKIKASLIGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2U1</accession>
    <name>B8E2U1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6 7">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recA</name>
        <name evidence="12" type="ordered locus">Dtur_1162</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 8">Belongs to the RecA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583523.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353055.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1162"/>
    <dbReference type="EnsemblBacteria" id="ACK42441">
        <property type="protein sequence ID" value="ACK42441"/>
        <property type="gene ID" value="Dtur_1162"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1162"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1199"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_3_2_0"/>
    <dbReference type="InParanoid" id="B8E2U1"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="RECA_2" evidence="10">
        <location>
            <begin position="33"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_3" evidence="11">
        <location>
            <begin position="197"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="356" mass="39100" checksum="BB9BAC5983F3BC78" modified="2009-03-03" version="1">MEKEKALESAIFQIEKQFGKGAIMRLGSQERFQVPVIPTGILTLDYALGVGGVPRGRIIELFGPEGSGKTTVALQIIASAQKMGGVAAFIDAEHAFDPNYARKIGVNLENLLISQPDTGEQALEIAEILVRSGGVDVIVIDSVAALVPRAELEGEMGDAFIGLQARLMSQALRKLTGVISKSKTVAIFINQLREKVGVFFGNPETTPGGRALKFYASVRIDVRKAESMKEGSEVTGTKVKVKVVKNKVAPPFREGEFELIYGEGISREGCILDAGVEAKVIERSGTWYIYKDIRLGQGRENAKTYLKEHPEIADEIEREVRKLWGFEETQAEGNKESSKEEEKEVKEEKTIRKSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2U5</accession>
    <name>B8E2U5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ordered locus">Dtur_1166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583527.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353059.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1166"/>
    <dbReference type="EnsemblBacteria" id="ACK42445">
        <property type="protein sequence ID" value="ACK42445"/>
        <property type="gene ID" value="Dtur_1166"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1166"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1203"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_0"/>
    <dbReference type="InParanoid" id="B8E2U5"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="483" mass="54113" checksum="FAB60BC1705641AC" modified="2009-03-03" version="1">MKTIKEIKDLYKNKEVSIKEVVEYYINKIKEWEPYIKAFLYVPYDNIEEQVKDLEKKDSKLPLYGVPIAIKDNILTKDIRTTCASKILENFIPPYDATVIKRLKENGAIIIGKTNLDEFAMGSSCENSAFGPTKNPWDIERVPGGSSGGSAACVSAGEVPVSLGSDTGGSIRLPASFTGVIGLKPTYGLVSRFGLVAFASSLDQIGPFGRTVEDIAIVLQVIAGHDPMDSTSSPYEIPNYLESLGKSVKDWKVGIPKELWQKGVSEEVLIILEKSFDVFKEMGVKVEEISLPSLEYALPVYYIISTSEASSNLARYDGVKYGYRDFWAEDLISMYKQTRGKGFGSEVKRRIILGTYALSAGYYDAYYLKATKVRRLIRMEFEEAFKKVDIIASPTSPVLPFKLGERISDPLQMYLTDIMTIPVNLAGIPAISMPAGFYNNLPVGIQFMSPFFTEDRLLQFAYIYQQFMNFSEKYPDLPNKERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2W5</accession>
    <name>B8E2W5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-terminal methylation motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353079.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1186"/>
    <dbReference type="EnsemblBacteria" id="ACK42465">
        <property type="protein sequence ID" value="ACK42465"/>
        <property type="gene ID" value="Dtur_1186"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1186"/>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007156_0_0_0"/>
    <dbReference type="OMA" id="DPHYTND"/>
    <dbReference type="OrthoDB" id="1871266at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="267" mass="30730" checksum="4E1B944A9747D7ED" modified="2009-03-03" version="1">MSLFKNLKGFSLVELLVSMTILLIIMSFSLPVFVSSGEKIKKTELSEIAKNIAFYTMEYIKARNITCQNNPEKGSIIDAKYGLSYGNSYTLGNDSSHYYPGLVDINGNPLSINISPSLPYQTYNNNPQAFYSVLQGFVPYGVSDPNLNNNRDKSTNLLPIIKYSKNIPKYIFRAKENYTPKIYTDDTRKTDPTSFDYDPHYTNDSNLLKNTTNYEGFRVLTRIVARKRYPNEPDHVQFYDVLVKVFWVYGNREYSYEVSSQIMTWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2W7</accession>
    <name>B8E2W7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1188</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583549.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353081.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1188"/>
    <dbReference type="EnsemblBacteria" id="ACK42467">
        <property type="protein sequence ID" value="ACK42467"/>
        <property type="gene ID" value="Dtur_1188"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1188"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1225"/>
    <dbReference type="eggNOG" id="COG0440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_1_3_0"/>
    <dbReference type="InParanoid" id="B8E2W7"/>
    <dbReference type="OMA" id="EPYGIKE"/>
    <dbReference type="OrthoDB" id="1500398at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="161" mass="18132" checksum="0563836FCC92A409" modified="2009-03-03" version="1">MQHTLSLIVENKPGVLARIAGLFSRRGYNIESLAVNTTEVPHLSRITLVVKGDEKVLEQITKQAYKLIEVVKVNDFTGVPVVERELALIRVKSDATTRRAIIDLVEIFRANIVDVSDKDLIIEITGDSEKIDAFKKNLEPYGIKEMVRTGKIVMERGLKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Z1</accession>
    <name>B8E2Z1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="4">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="4">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truB</name>
        <name evidence="7" type="ordered locus">Dtur_1212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583573.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353105.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1212"/>
    <dbReference type="EnsemblBacteria" id="ACK42491">
        <property type="protein sequence ID" value="ACK42491"/>
        <property type="gene ID" value="Dtur_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1212"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1250"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2Z1"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015240">
        <property type="entry name" value="tRNA_sdUridine_synth_fam1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09157">
        <property type="entry name" value="TruB-C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TruB_N" evidence="5">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="TruB-C_2" evidence="6">
        <location>
            <begin position="237"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="288" mass="32932" checksum="3CACDA18549CB320" modified="2009-03-03" version="1">MNGFILINKPPGITSFDVVKKVKRLFKEKKVGHMGTLDPRACGLLIIGLGKYVRLEEYILRLPKTYIVEILFGVSSDTYDREAYSFFYEKEKKQIDLRELEDVLKYFIGEIEQTPPPYSAIHIDGERAYNLARKNISINLPKRRVIIYESKILDFNKSMNKALIEFKVSSGTYIRSLVNDIGKKLNIKALVSFLVRTQIGHLSVNQSVSYSKLKETEINNLLLSPIEVLSFPVYQTSKDEEKKILNGNSIESRLFQDGEYVSLINAQNRFIAVGKVIGNTIKPEKVFP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Z9</accession>
    <name>COAX_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type III pantothenate kinase</fullName>
            <ecNumber evidence="1">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaX</name>
        <name type="ordered locus">Dtur_1220</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583581.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353113.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2Z9"/>
    <dbReference type="SMR" id="B8E2Z9"/>
    <dbReference type="STRING" id="515635.Dtur_1220"/>
    <dbReference type="EnsemblBacteria" id="ACK42499">
        <property type="protein sequence ID" value="ACK42499"/>
        <property type="gene ID" value="Dtur_1220"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1220"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1258"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066627_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2Z9"/>
    <dbReference type="OMA" id="HEPWLTL"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000140241" description="Type III pantothenate kinase">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <sequence length="255" mass="28009" checksum="677EF8DF1C4D2C05" modified="2009-03-03" version="1">MILTIDIGNSNIDLAYFNGNKIVSHYEFETKKFSTSYEYALIIEWTLKREKLQEKDILGVALSSVVPSLTSAFIDAIKYLFGKPPFVVEPGIKTGISIETENPKEVGADLICNVVAITEEYGHCGIAVDFGTATTFSVVEKKKFLGAAIAPGVGTSAFALFEKTAKLPQVDIKAPESSLGKNTISAIQAGIVYGFAGLVDGILERQIKELKYKPVLVSTGGWAKRIVPYTKYLKEKDIDPYLTLKGLYYLYLKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E303</accession>
    <name>B8E303_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583585.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353117.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1225"/>
    <dbReference type="EnsemblBacteria" id="ACK42503">
        <property type="protein sequence ID" value="ACK42503"/>
        <property type="gene ID" value="Dtur_1225"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1225"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1264"/>
    <dbReference type="eggNOG" id="COG1313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_0"/>
    <dbReference type="InParanoid" id="B8E303"/>
    <dbReference type="OMA" id="GGEPTPN"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="77"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="301" mass="34947" checksum="16C42FF70967E8AD" modified="2009-03-03" version="1">MLPSYITLYKSGELKKRVNFLKEILKNCTLCPRKCMVNRERGELGYCKAPYKPVISSYFPHFGEEKILVGKNGSGTIFFTFCNLGCVFCQNYTISHLGVGEEMSTEDLAYIMIYLQNLGCHNINLVTPTHFISQIIEALLKAIEFGLKIPIVYNTSGYESLETLKLLDGIVDIYMPDIKFYYPETAKKFANAEDYPEVTKSALKEMYRQVGNLILNEENIALKGLIIRHLLMPNHISELREWLIFIKKELSTEVFINIMEQYRPLYMAYKYPEINRTINYKEYQEAISIAKNLGFKNLYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E316</accession>
    <name>B8E316_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1238</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583598.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353130.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1238"/>
    <dbReference type="EnsemblBacteria" id="ACK42516">
        <property type="protein sequence ID" value="ACK42516"/>
        <property type="gene ID" value="Dtur_1238"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1238"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1278"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_0_0"/>
    <dbReference type="InParanoid" id="B8E316"/>
    <dbReference type="OMA" id="IEWHMIG"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="235" mass="27341" checksum="3D03654BA426DE25" modified="2009-03-03" version="1">MNDLSFIAENWKRVQERIIKKAEECGRDPSEISVVAVAKGYPPEYIREAVKIGINKIGENRVQEAEKKISLLSDLPCEWHMVGHLQRNKVKKAVKMFFLIHSVDSLDLAEEINKHAGKEGKKVDILLQLNLSKEPTKHGFKEEEFWRTYEKIFALKNLNIKGLMTIGPLTQDKDAIREVFRKLYNIWKKLIELTKLDLPYLSMGMSEDFEIAIEEGSNILRLGRIIFQKDFEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E317</accession>
    <name>B8E317_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583599.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353131.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1239"/>
    <dbReference type="EnsemblBacteria" id="ACK42517">
        <property type="protein sequence ID" value="ACK42517"/>
        <property type="gene ID" value="Dtur_1239"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1239"/>
    <dbReference type="HOGENOM" id="CLU_920494_0_0_0"/>
    <dbReference type="OMA" id="YLVINCE"/>
    <dbReference type="OrthoDB" id="2114504at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="302" mass="36100" checksum="D4B4A44D9A58C703" modified="2009-03-03" version="1">MTLYREDFYKIQKNKRLFRPKRFLILLITLVTFALVIFLITRWKENYEIIGIFVFDEQVLRAPLDGILRTNVREMEKVRVGQVVGYIEDTNKRTSPEEDILGDKYKDTLKTLDEIGEKINLSIDELRIEAFLGDFSRYNEIVENIKRLSFLRKEYIIKLDTIYEELQKLKKKYENLIISEKSGYAIFHIDNLVKNDLKWKTLAWEDLKKARYSYYLNRKVKKGEIIGVIRDFPPKYLVLFSKAPFERNKYLIINCNDRIIIKVKILEVEVLKNFYKISTLPIEIDNIILKERIIKGRVLKVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E325</accession>
    <name>MURG_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murG</name>
        <name type="ordered locus">Dtur_1247</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583607.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353139.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E325"/>
    <dbReference type="SMR" id="B8E325"/>
    <dbReference type="STRING" id="515635.Dtur_1247"/>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42525">
        <property type="protein sequence ID" value="ACK42525"/>
        <property type="gene ID" value="Dtur_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1247"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1287"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_0_1_0"/>
    <dbReference type="InParanoid" id="B8E325"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000116474" description="UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <sequence length="360" mass="40688" checksum="C18DE3DA923335A7" modified="2009-03-03" version="1">MINILFVAGGTGGHVIPALNMADYISERAPHWKISFIGRKNSFEEKLIAGKYDFYGLDIIKSSDIKKLSYYLSIKDALKILGELEPDILVVFGSYITVPIIVASIIKKLPFFLHEQNVIPGRVTKLFYRFSQGVAVSFPETREYFKDKDKIYLTGNFVRTELLTMDKASCKKELGFDENRKLLLITGGSQGSMKINYEVKKIIPYLLNNGWQILHQIGEKNYVSYIEGIPIEEWAKEGYNPVPFIKNMELAICGADFAISRAGATTIAQFLIAGLPAIYIPYPYAKDNHQIYNAEVVVKVGGGELLLENQLNSEKLITLLDKWDNKDRLAKASEACRKISIANGRENFWNLILEKLEGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E329</accession>
    <name>B8E329_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">murF</name>
        <name evidence="11" type="ordered locus">Dtur_1251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583611.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353143.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1251"/>
    <dbReference type="EnsemblBacteria" id="ACK42529">
        <property type="protein sequence ID" value="ACK42529"/>
        <property type="gene ID" value="Dtur_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1251"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1291"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_1_1_0"/>
    <dbReference type="InParanoid" id="B8E329"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="110"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="318"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="459" mass="52315" checksum="5BC2DDDB21B268FC" modified="2009-03-03" version="1">MKLDLTVEDILEATNGVLIKGDIREKVDSISTDTRNINEDEVFIALKGEKFDGHDFVKDAILKGVKGIIISREIAVEGNIFVIRVQDTLKALQDIANYYRRKLKTKVIGVTGSSGKTTTKNLIGKLLSIVGKTYVSRENFNNEIGVPLSILDAEEDVDFLVLEMAMRNKGEISLLSKIAEPDIGVITNIGWAHIGRLGSREAIMEAKAEIFEHIKQDGVAILNNDDPFSMRIYEKLKIKKYTFGFDERSDLRGEIVEKNEENYLLKINFPDGKDIKLSLPIYPLNIYRNLLLSLLVLWVISPESVYSLEKDFYFDLPKQRLNLKRKENGLVIIDDTYNANPDSMRTAIEYLDLLKSSGRKIVLLGDMLELGDHSIDGHREVIEEVFKRNIDMAIFYGPEMRKALDTYQNLDKKRIYWSKDPEEIKSILKNSLCAGDTILVKGSRAMYMENFVKFLEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E334</accession>
    <name>B8E334_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5981 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583983.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353522.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1635"/>
    <dbReference type="EnsemblBacteria" id="ACK42908">
        <property type="protein sequence ID" value="ACK42908"/>
        <property type="gene ID" value="Dtur_1635"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1635"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107569_0_0_0"/>
    <dbReference type="InParanoid" id="B8E334"/>
    <dbReference type="OMA" id="TRQCDPE"/>
    <dbReference type="OrthoDB" id="1284428at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022026">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12225">
        <property type="entry name" value="DUF5981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5981" evidence="1">
        <location>
            <begin position="104"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="201" mass="22772" checksum="37AD669FBFA61412" modified="2009-03-03" version="1">MRLEFKPIEEIKGFVKGNKVFVFSCDNCGFAKVEEKNQQVLDYISALGYELVGMYTLKKEECNVGSFLKIVKDLKGVNEAEAILTFTCGGLPQIIPNYVKKQVFPATNTLKIEPGRSLGSFARLCSACGECWIYYTGNLCMEKLCPKKMRNGPCGGSEEGMCEVFNRLCPWVILFKNKRITEEEFLKIIPPKDFSKILFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E339</accession>
    <name>B8E339_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583988.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353527.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1640"/>
    <dbReference type="EnsemblBacteria" id="ACK42913">
        <property type="protein sequence ID" value="ACK42913"/>
        <property type="gene ID" value="Dtur_1640"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1640"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029471_0_0_0"/>
    <dbReference type="InParanoid" id="B8E339"/>
    <dbReference type="OMA" id="NIHIRDY"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034015">
        <property type="term" value="F:L-ribulose-5-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019852">
        <property type="term" value="P:L-ascorbic acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="33"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="270" mass="31450" checksum="2DFD1D4C9F89CFCF" modified="2009-03-03" version="1">MLISCSTAAFINPEMTIDEKLKNSIEALTTILENNFDGIELFLPKDFDEEKRETLFNEAKKIRGKILTLHAPKNILHKPIKSVLPDLVKLIKECYELEIKIIVMHPPFQKSMDSLLKNVFSIFDNVIHFASRHNVILTIENVPYLLDPPQFYSALVKRYRNSIGITIDVEYLHSTKYSLDKYPKELLKNYLRNIHIRDYDGQSFDEEGKRRYLKLGEGLINFKELFEKIFEIGYDGPLTVETVFDNKIEDLKYSRNFIIKNLPQKSLASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E367</accession>
    <name>B8E367_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the serpin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584016.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353555.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1669"/>
    <dbReference type="MEROPS" id="I04.089"/>
    <dbReference type="EnsemblBacteria" id="ACK42941">
        <property type="protein sequence ID" value="ACK42941"/>
        <property type="gene ID" value="Dtur_1669"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1669"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1719"/>
    <dbReference type="eggNOG" id="COG4826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023330_0_1_0"/>
    <dbReference type="InParanoid" id="B8E367"/>
    <dbReference type="OMA" id="KDVWRGL"/>
    <dbReference type="OrthoDB" id="1712777at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.39.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.497.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023795">
        <property type="entry name" value="Serpin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023796">
        <property type="entry name" value="Serpin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000215">
        <property type="entry name" value="Serpin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036186">
        <property type="entry name" value="Serpin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042178">
        <property type="entry name" value="Serpin_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042185">
        <property type="entry name" value="Serpin_sf_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11461">
        <property type="entry name" value="PTHR11461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00079">
        <property type="entry name" value="Serpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00093">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56574">
        <property type="entry name" value="SSF56574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00284">
        <property type="entry name" value="SERPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002871099" evidence="2">
        <location>
            <begin position="22"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="SERPIN" evidence="3">
        <location>
            <begin position="40"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="400" mass="46116" checksum="FD301DEBB8736604" modified="2009-03-03" version="1">MKNTTKIFVLLILLIFSFALAENVDKNLLTIAKGNNLFGLNLYQKLTIKEGGNIFISPYSISSALAMTYAGASGNTKKQMSEVLYFNLPDDELHFAFSKLNSILNTPKSDFQLAIANSLWGQINYPFQEDFLDLVKKYYSAGFNLVDFVDEINREKARNEINKWVEDRTNQKIRELIHKEDLNPMTRLVLVNAIYFKGKWKYTFNKEETREMPFFLNENKTLKVSMMHQINEFNYYEDKNLQAIELPYSGNELSMVVILPKERNLSKIEKNLTYDMLNSISRSMEKEKVDLYIPRFKIEKRYILNEALMKLGMTDAFIDMLADFSGMTGDKDLYISKVIHQSFIEVNEEGTEAAAATAVIMSGKSIGLGPKVFKADHPFLFFIIHKPTNTILFMGRFIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E392</accession>
    <name>B8E392_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353580.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1694"/>
    <dbReference type="EnsemblBacteria" id="ACK42966">
        <property type="protein sequence ID" value="ACK42966"/>
        <property type="gene ID" value="Dtur_1694"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1694"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1745"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_635744_0_0_0"/>
    <dbReference type="InParanoid" id="B8E392"/>
    <dbReference type="OMA" id="FITMEND"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052621">
        <property type="term" value="F:diguanylate cyclase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043709">
        <property type="term" value="P:cell adhesion involved in single-species biofilm formation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902201">
        <property type="term" value="P:negative regulation of bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007892">
        <property type="entry name" value="CHASE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05228">
        <property type="entry name" value="CHASE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="311"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="431" mass="51292" checksum="7B3A126B5C095D92" modified="2009-03-03" version="1">MTKEVEAYKRTILYIINREKQILKNQIKDYTYWKDLGENAVVKRDKLWIKSNINPWIKNTLGYDVVLFTEDRRVITSSFNFPLNKIPLKREIEISLMEINKDFYLYAVGPVYDENRKKFYGAYLLFARKVDTEYIKGLEEIMGIRLTFVSKDSSNKVSLEDYYKYPYLHMVVPLENGIYVVMDKEDTSLHEFNKMILIIFGISLGIILILSISLIRVLLNITFKPFEKLVEVSHKIANGEYEIELIKNRDDELGDFIKAFTYMISKIKEREEKLKWEKRETEKLAYLDHLTGVYNRRFLEESYEDIKRNHSLFSLVFVDLDNFKNINDRWGHELGDRVLVNVSEFFKKNFRDYDILVRYGGDEFCIILLNIDKDTAEKIVHRVKEKFEIEMMSSFGFNLSFTYGIAEYPKDGEDLNTLLKVADERMYKYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3A9</accession>
    <name>B8E3A9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584058.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353597.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42983">
        <property type="protein sequence ID" value="ACK42983"/>
        <property type="gene ID" value="Dtur_1711"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1711"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1762"/>
    <dbReference type="eggNOG" id="ENOG5032Y2U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194452_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3A9"/>
    <dbReference type="OMA" id="LPACYFT"/>
    <dbReference type="OrthoDB" id="1961566at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="64" mass="7452" checksum="BC774F4DF89BA517" modified="2009-03-03" version="1">MAECRVEKNLKNCNCTYEPCPRKGICCECLAYHRSHGELPACYFPPEVERTYDRSIGKFVSLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3B5</accession>
    <name>B8E3B5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584064.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353603.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1717"/>
    <dbReference type="EnsemblBacteria" id="ACK42989">
        <property type="protein sequence ID" value="ACK42989"/>
        <property type="gene ID" value="Dtur_1717"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1717"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1769"/>
    <dbReference type="eggNOG" id="COG2768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046240_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3B5"/>
    <dbReference type="OMA" id="MNHFKGH"/>
    <dbReference type="OrthoDB" id="1000643at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="216"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="369" mass="40513" checksum="8048FF0BB2B79F8F" modified="2009-03-03" version="1">MKAPLYFISMRATNENESLVRKIKRLTKKLLEGRIEKGALVAIKLTFGEPGNHAFIRPVFVRQAVEAVRELGGKPFLTDANTLYKGGRANAVDHLESAIYNGFGYSSVGAPLIIADGINGDYYKEVEVNLKHFKKIKVAGAIYDADFLLVLTHVKGHMSAGLGGAIKNVGMGCAPRSGKQMQHAQFKPNPNPNLCIGCRRCVDHCPTGALEMVDKKSKLTRPELCIGCGECAVVCPTSAIKILWNESAIGLQEKMVEFTYGILKQKEPKYAFINFVMDVSPDCDCAGWHDANLVPDVGILGGWDIVAIDQASSDLINKQIGLRDTALKSGFNPGEDKLRAVHPDIDWSWQIKYAEEIGLGTKEYELIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYM2</accession>
    <name>B8DYM2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
            <ecNumber evidence="2">3.5.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="3.5.1.14" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582490.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352018.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0066"/>
    <dbReference type="EnsemblBacteria" id="ACK41404">
        <property type="protein sequence ID" value="ACK41404"/>
        <property type="gene ID" value="Dtur_0066"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0066"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYM2"/>
    <dbReference type="OMA" id="RAHACGH"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="188"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="390" mass="43610" checksum="9222F456BB23248F" modified="2009-03-03" version="1">MNIKEDIQKIMPEVINIRRDIHMYPELGFQEFRTSQLIASYLENLELEVRKNIAQTGVLGILRGKEEGKTILLRADIDALPLEELNDVPYKSKNKGIMHACGHDGHIAILLGTAKILAKYKDQIKGIVKFAFQPAEELPPGGAEPMIKEGILENPYVDKVYALHLANHLKVGKIAVRKGFFCAQADAFTIKVKGRGGHGSTPDKCIDPIIISTHIVQALQEIPSREIDPHTPFVLSICKIQSGNTFNVIPEDAEIEGTVRTFDKNLAETISKRIETISKNIAEAFRGKAEIEYQFGYPPGKNDEKEAEFVKKIAEEVVGKENVIEDKPSMGGEDFSYFLEERPGAMFWLGSGNEEKGLNHPHHSPYFDFDESAMAIGIEMFVRIVLENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYM9</accession>
    <name>B8DYM9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582497.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352025.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0073"/>
    <dbReference type="EnsemblBacteria" id="ACK41411">
        <property type="protein sequence ID" value="ACK41411"/>
        <property type="gene ID" value="Dtur_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0073"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.74"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_3_0_0"/>
    <dbReference type="InParanoid" id="B8DYM9"/>
    <dbReference type="OMA" id="AQEDYKM"/>
    <dbReference type="OrthoDB" id="1149455at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047150">
        <property type="term" value="F:betaine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017226">
        <property type="entry name" value="Betaine-hCys_S-MeTrfase_BHMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037505">
        <property type="entry name" value="Betaine_HMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR037505-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="290" mass="32312" checksum="D54FDE5A1DF5E644" modified="2009-03-03" version="1">MSNKKIKLPEFLFFDGAMGTELQRRGLPPGTPPEILNLENPSLVEEVHKDYIKAGSMVIETNTFGGNRVRLQRAGLEEKIKEINEKGVEIAQKASEGKVLIAGSVGPLGELIEPYGDISEEEAEEFFTEQIEILVNSGVDLILIETMISLNEALIALKSAKKFDIPVGVTMSFEWTEKGGRTPFGDEVEYSIKKLEENGADFVGSNCGKGFEDMLKIAPIIRRSTRLPVLIQPNAGIPRWENGKLLYPESPEKFKTFVDEMIKLKINFIGGCCGTTPKHIEVFKEFYLKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYS2</accession>
    <name>RL34_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmH</name>
        <name type="ordered locus">Dtur_0122</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012547104.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352068.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DYS2"/>
    <dbReference type="SMR" id="B8DYS2"/>
    <dbReference type="STRING" id="515635.Dtur_0122"/>
    <dbReference type="EnsemblBacteria" id="ACK41454">
        <property type="protein sequence ID" value="ACK41454"/>
        <property type="gene ID" value="Dtur_0122"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0122"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.128"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_0"/>
    <dbReference type="InParanoid" id="B8DYS2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000196039" description="50S ribosomal protein L34">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <sequence length="44" mass="5407" checksum="74BC6EEF20795728" modified="2009-03-03" version="1">MKRTYQPKKHHRKRVHGFLARMRTPGGRRVIKRRRAKGRKRLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYS9</accession>
    <name>B8DYS9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpC</name>
        <name evidence="9" type="ordered locus">Dtur_0129</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582546.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352075.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0129"/>
    <dbReference type="EnsemblBacteria" id="ACK41461">
        <property type="protein sequence ID" value="ACK41461"/>
        <property type="gene ID" value="Dtur_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0129"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1783784_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYS9"/>
    <dbReference type="OMA" id="MGGFAEI"/>
    <dbReference type="OrthoDB" id="1696893at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6 7" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="3 6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="8">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="145" mass="16452" checksum="05D4E5A7B291C7DD" modified="2009-03-03" version="1">MKKESTSKRLYLEVNTPMKSVFRGFVDAVSIPLEDGMIGILPGHVNTLARVMPGIIKARSGDKEIILVVSEGFMEITKDKIYIVAEDGELGERLNEDVLKKEEIELKNKLNQAQNYKEREELHKALLLNSLKQKAVKLYTTYSTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYT0</accession>
    <name>ATPB_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit beta</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpD</name>
        <name type="ordered locus">Dtur_0130</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582547.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352076.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DYT0"/>
    <dbReference type="SMR" id="B8DYT0"/>
    <dbReference type="STRING" id="515635.Dtur_0130"/>
    <dbReference type="PRIDE" id="B8DYT0"/>
    <dbReference type="EnsemblBacteria" id="ACK41462">
        <property type="protein sequence ID" value="ACK41462"/>
        <property type="gene ID" value="Dtur_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0130"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.135"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_0"/>
    <dbReference type="InParanoid" id="B8DYT0"/>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000143498" description="ATP synthase subunit beta">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="149"/>
            <end position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <sequence length="465" mass="50885" checksum="048BD29189E613AA" modified="2009-03-03" version="1">MEGEIIAVNGPVIDIYFPDDVPNVYEALELENPVKNEKLVLETRILLGDHRVRAIALGSTDGISRGLKVKRTFHPISVPVSEEVLGRVVNVFGEPIDGGDKIKGEMTPIIKNAVEFRRVEPSYSILETGIKAIDLLTPFPQGGKIGLFGGAGVGKTVLIMELIHNVAVAHGGISVFAGIGERSREGNELWLEMKESGVLSKAVLVFGQMNEPPGVRMRVPLTALTIAEYFRDYLGKDVLLLMDNIFRYVQAGMEVSSMLGRIPSAVGYQPTLITELGEVEERILSTDTGSITAVQAVYVPADDLTDPAPATIFSHLDSTLVLSRSIAEMGIYPAVDPLASSSQILEPKFVGYEHAEVARKVVEILQHYESLKDIISILGVEELSEEDRVIVNRARKIQLFLSQPLFVAAAYTNIPGVYVPREKTIEGFKAIIEGEVDDLPEDAFYMVGTLEDVKKKAQEHGALMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYV5</accession>
    <name>B8DYV5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0156</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582572.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352101.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0156"/>
    <dbReference type="EnsemblBacteria" id="ACK41487">
        <property type="protein sequence ID" value="ACK41487"/>
        <property type="gene ID" value="Dtur_0156"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0156"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_719108_0_0_0"/>
    <dbReference type="OMA" id="FHHEHAN"/>
    <dbReference type="OrthoDB" id="754057at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="390" mass="45109" checksum="34E4FC469EB09886" modified="2009-03-03" version="1">MLEKLGLIFSSFSYIFQIPFIFYLILRVKKLRIKFIEDDKDKIILVLLFISGVISSLLSSKKLEAFLVSLIPFIFVGFYILGKEGLKESNKNIIYYILLGSSILGFILFVSRIFNFSLYILEFPIVDGNAPRGLVLGVKSQGLSLLLEFGIVSGIGLLVYFERNIRDILKILLLLVFCILGFMITETRGGILGILVGLIVLISNKEFLNQLKRKWKYVLLIVFLFILAFFIFFNQFYNKLTISLQKGRQGSIYERIYIYLGTLRMIKDNLLFGVGPGCFVYEYPKYALKNFPYVPEFILGELSHAVTTHNIYFYFLSGWGIIGSSFFFYWLFKKIYKGLKFNYSLDKHIILAILMVYFGHVLLDDLFSIHVPLLIGLLNRNKEYTLVLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYV8</accession>
    <name>B8DYV8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582575.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352104.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0159"/>
    <dbReference type="EnsemblBacteria" id="ACK41490">
        <property type="protein sequence ID" value="ACK41490"/>
        <property type="gene ID" value="Dtur_0159"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0159"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8DYV8"/>
    <dbReference type="OMA" id="ICMEMEP"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="331" mass="36973" checksum="BDF5F04166B60BEA" modified="2009-03-03" version="1">MEVLRIENLRAYYVTSLYGVERRVRAVDNVNLEVLENEILGIAGESGCGKSTLLKTMIGLIKPPLTVLDGKILYKFNGEEIDIISKKDEITSLKWKVFSYVPQGSMSVLNPTRKIIKTFEDLLKVHLKIEDKGEIRKISEEHLKALGLPSEVLNSYPHQLSGGMRQRVTIALSTILKPKVIIADEATTALDVVVQRGVIQLLKKIQSEFKNSIVIVTHDMGVHANIADRIVIMYAGKILEIGSARDIFKNPLHPYTKYLIESLPKIGDKSLRKSVPGAPPSLLNPPKGCRFHPRCNMAMEICKKEVPALVDVKNGHKVACFLHSKEAEIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYZ5</accession>
    <name>B8DYZ5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582706.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352235.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0299"/>
    <dbReference type="EnsemblBacteria" id="ACK41621">
        <property type="protein sequence ID" value="ACK41621"/>
        <property type="gene ID" value="Dtur_0299"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0299"/>
    <dbReference type="eggNOG" id="ENOG50339M2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110735_7_1_0"/>
    <dbReference type="OMA" id="DERAVWM"/>
    <dbReference type="OrthoDB" id="1990469at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009936">
        <property type="entry name" value="DUF1468"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07331">
        <property type="entry name" value="TctB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="150" mass="17199" checksum="C70DF33D0D0E0B2F" modified="2009-03-03" version="1">MRLRFSWDTGIGIGIVLFGFFILINALNMPNMPLGLGPGDFPEIVSIGLIICGIILAIQSIRKMEKTKKMYSANSLRDILILIFLSLLYVYLVSYLGFLYLTPFLMFATMYLFGYRKIPYAIVISIIFTLLVYYVFYGIFKVPLPQFSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ03</accession>
    <name>B8DZ03_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582714.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352243.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0307"/>
    <dbReference type="EnsemblBacteria" id="ACK41629">
        <property type="protein sequence ID" value="ACK41629"/>
        <property type="gene ID" value="Dtur_0307"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0307"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.324"/>
    <dbReference type="eggNOG" id="COG1904">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029823_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ03"/>
    <dbReference type="OMA" id="FGCWWFL"/>
    <dbReference type="OrthoDB" id="167900at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="402" mass="47922" checksum="08373689F432DC73" modified="2009-03-03" version="1">MLSERDLEIKIENALNKIKIIDIHTHLFPPSFKDLFLYGIDSLLTYHYLIAETIRYLSISPEDFYALSLKTQANLVWKTLFLERSPISESARGIVTIFKELGIDLGERDLSKIRIYFEKIDNGEYVDLIFEKANIDYVVMTNDPFDEREMDYWRKNMVKDKRFRASLRLDRLITDWEKLKKHLKIKDYTEIRKHLDEWFAIMNPLYIAFSFPPKFKYPDHSFRSTILEEIISYAEERKIPIAFMMGAKRAVNPALKLAGDSVGRSNIESIENLCRSFPNNKFMVTMLSRENQYELCVTARKFKNLMIFGCWWFLNTPSLIEEITKMRIELLGFSFIPQHSDARVLEQLIYKWKNSKEIIKKVVYEKYLDLIKSGWILKEEDIERDLSQLFRRNFEEFVLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ51</accession>
    <name>B8DZ51_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CARDB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582762.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352291.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0373"/>
    <dbReference type="EnsemblBacteria" id="ACK41677">
        <property type="protein sequence ID" value="ACK41677"/>
        <property type="gene ID" value="Dtur_0373"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0373"/>
    <dbReference type="HOGENOM" id="CLU_952272_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870550" description="CARDB domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="215"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="292" mass="32688" checksum="AC09CEC860840376" modified="2009-03-03" version="1">MKSSKLLKLLAITLFLMVIAGCSAKQNTQPPETPTSLETPTNTTSLILIGYNDAWQSGTKDGLYGYDPNGGWGDIEYIFSTDVRYCKPWDAGFVLTFDQNIDSFFYIAIYNADDTPKILYINTYDNKTPPYNWKNILKEEIKADTAKKFQVIKVNISKDDFYDNENSREGIQQQFSIYAADINGNGVDTVKVAYIGNPGEKPELLFSKVEWGPNLVVDISNIGLKPAENVTVNIYSYENGQPQILATQTISLLNPNTTKELIFENASNATEIRIDPDNTIEEIIEENNLTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ67</accession>
    <name>B8DZ67_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0389</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582778.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352307.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0389"/>
    <dbReference type="EnsemblBacteria" id="ACK41693">
        <property type="protein sequence ID" value="ACK41693"/>
        <property type="gene ID" value="Dtur_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0389"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="InParanoid" id="B8DZ67"/>
    <dbReference type="OMA" id="ETWYAMS"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031640">
        <property type="entry name" value="Glu_dehyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16912">
        <property type="entry name" value="Glu_dehyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="3">
        <location>
            <begin position="27"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Glu_dehyd_C" evidence="4">
        <location>
            <begin position="142"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="341" mass="38217" checksum="6206023FDABADC1A" modified="2009-03-03" version="1">MKNMGWLLKDIKKLELIETPLEKPKENDVLLEVIYAGICGSDLHAYLGEHPFVKPGIVLGHEFVGKVIEKGENVRNVDLNDVVVIEPSLTCGICYNCTHGRYNICKNLDVIGCTKTNGGFQKYIKIPSHKVYKVNEVPLKRAVLTEPLAVAVHGVRRSSFKPGDEVLVIGSGPIGLLTTIFLYLSSAKKIVLVDVLDKRLNLAKNLCPGIITVKPENLNLSLFTQEGPDLVFECVGVDQTINLAIEYARKGTDIILMGVPKEISMAKLIYIQDRELNLKGSLMYTKDDYLIALELLRKNQVNYEALITHIYPFDKVPQAFEDILNYKDQYFKVIIDVKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ72</accession>
    <name>B8DZ72_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DsrE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582890.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352419.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0512"/>
    <dbReference type="EnsemblBacteria" id="ACK41805">
        <property type="protein sequence ID" value="ACK41805"/>
        <property type="gene ID" value="Dtur_0512"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0512"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.543"/>
    <dbReference type="eggNOG" id="COG1553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151801_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZ72"/>
    <dbReference type="OMA" id="PQDDRNI"/>
    <dbReference type="OrthoDB" id="1997912at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003787">
        <property type="entry name" value="Sulphur_relay_DsrE/F-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02635">
        <property type="entry name" value="DrsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="117" mass="13036" checksum="DA2BAE39E10BBFE7" modified="2009-03-03" version="1">MYIVIQVNVPPYTYEDLDTAIHLAEAALKRGHKVSIFLFADSVLSINSKVKPLRVDRNIPLKMKELSEKGVEIHICGLCAEYRGISSENAVEGPKFSGVPEMASLIFNADRYVNLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ89</accession>
    <name>B8DZ89_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582907.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352436.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41822">
        <property type="protein sequence ID" value="ACK41822"/>
        <property type="gene ID" value="Dtur_0530"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0530"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.564"/>
    <dbReference type="HOGENOM" id="CLU_2681820_0_0_0"/>
    <dbReference type="OMA" id="GYGAPWC"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035205">
        <property type="entry name" value="DUF5320"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17253">
        <property type="entry name" value="DUF5320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="77" mass="9604" checksum="6B7BB280796F5620" modified="2009-03-03" version="1">MRWWYGRGWGRGWGFGGYGAPWCPWSYWNLGRRWWWRGPGYYPYGLTKEEEKELLEEWKKDLEADLEDIKRRLDEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZB2</accession>
    <name>B8DZB2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Laminarinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582930.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352459.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0555"/>
    <dbReference type="CAZy" id="CBM4">
        <property type="family name" value="Carbohydrate-Binding Module Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41845">
        <property type="protein sequence ID" value="ACK41845"/>
        <property type="gene ID" value="Dtur_0555"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0555"/>
    <dbReference type="eggNOG" id="COG2273">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1388327_0_0_0"/>
    <dbReference type="OMA" id="DAFWHIQ"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870554" evidence="1">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="2">
        <location>
            <begin position="66"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="196" mass="21992" checksum="F22103E8D42702AE" modified="2009-03-03" version="1">MKKFYLLLLLISFIIFIAGCASAPQVSQKETTSGVVEVTTPEGKAQVINVTKLGVFTENLMFSAPSNWYIVIQGTAEVEEYGAKNGAFYVKIKNPGDAFWHIQFGTHVPIPAGKKYKITFEAKADAARDLQVRVIQDQTWEIVESKVFDLTTEMQKFEWEFTPKKDGHIVVFDMGKVSEKSIATTIYLANVELVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZF5</accession>
    <name>B8DZF5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582973.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352502.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0600"/>
    <dbReference type="ESTHER" id="dictd-b8dzf5">
        <property type="family name" value="Monoglyceridelipase_lysophospholip"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41888">
        <property type="protein sequence ID" value="ACK41888"/>
        <property type="gene ID" value="Dtur_0600"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0600"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.636"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026209_7_2_0"/>
    <dbReference type="InParanoid" id="B8DZF5"/>
    <dbReference type="OMA" id="FHGFSDH"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="10"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="253" mass="29168" checksum="1A7B42C0C30391C0" modified="2009-03-03" version="1">MIYSFRRGEPQKGWVVVVHGLGEHIGRYEKLINDLGERGYGVIGFDHPGHGRSDGKRGDTTIEEIISVIDNLTSDIDKFHLFGHSLGGLIATRYAEERQEKIKSLVISAPALGVEVDPLTNFIAKTFGKILPRVTINNKLDPEYLSRNKKVIEKCMNDPLMHNKISFRLGLSMMENIKKAHEKAPYLKVPVLILVPTEDRYVDPNGAREFFKKLTYEDRKIVEFPGGYHELFEDEEYKDEFYKNIYDWIERHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZH2</accession>
    <name>B8DZH2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase</fullName>
            <ecNumber evidence="2">2.7.6.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582990.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352519.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0617"/>
    <dbReference type="EnsemblBacteria" id="ACK41905">
        <property type="protein sequence ID" value="ACK41905"/>
        <property type="gene ID" value="Dtur_0617"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0617"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.654"/>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097916_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZH2"/>
    <dbReference type="OMA" id="QVILRQN"/>
    <dbReference type="OrthoDB" id="1953248at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="8">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="155" mass="18002" checksum="260CBBF6770CA6D8" modified="2009-03-03" version="1">MHKVFIAIGSNIGDRRKNIETALKKMEELGLRIIKKSSIIETEPYGYKDQDKFLNGVVLVETGFDPFELLELLLNIEKEMGRERKIKWGPRNIDLDIIFYDDLVIDTENLKIPHPDAHNRTFVMGPLSEIAPDFVHPVLKKRVEEIYKELIEKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZH4</accession>
    <name>B8DZH4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cas1</name>
        <name evidence="11" type="ordered locus">Dtur_0619</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582992.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352521.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0619"/>
    <dbReference type="EnsemblBacteria" id="ACK41907">
        <property type="protein sequence ID" value="ACK41907"/>
        <property type="gene ID" value="Dtur_0619"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0619"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.656"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZH4"/>
    <dbReference type="OMA" id="AYKLIKH"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09722">
        <property type="entry name" value="Cas1_I-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019858">
        <property type="entry name" value="CRISPR-assoc_Cas1_HMARI/TNEAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43219">
        <property type="entry name" value="PTHR43219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03641">
        <property type="entry name" value="cas1_HMARI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="331" mass="39616" checksum="6235AEB9DEAE4EDE" modified="2009-03-03" version="1">MSESIYIFSSGELKRKHNTIFFETSDGQKKYLPIENIRDIHFFGEVTLNKEFLELISQKEIILHFYNYYEYYIGSFYPREHYNSGFMVLKQAEHYLDNEKRLKIATKIVKGASGNIKRVINYYLNREKKELEDYLERIQELEEKIDITNNVDGLMGIEGNIRDIYYSCFNIITEKEEFFIDERTKRPPSNYMNALISFGNSLLYTTTLSEIYKTHLDPRIGYLHTTNFRRFTLNLDVAEIFKPIIVDRIIFSLVNKGEITPKDFEEKLDGVYMNEKGMKIFVQNFEERMKTTIQYKNLGKVSYRRLIRLELYKLEKHLIGEEEYEPYISSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZN7</accession>
    <name>B8DZN7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583055.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352584.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0685"/>
    <dbReference type="EnsemblBacteria" id="ACK41970">
        <property type="protein sequence ID" value="ACK41970"/>
        <property type="gene ID" value="Dtur_0685"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0685"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.723"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="InParanoid" id="B8DZN7"/>
    <dbReference type="OMA" id="THCENRT"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="PKS_ER" evidence="2">
        <location>
            <begin position="10"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="338" mass="36714" checksum="9923F09CA0669537" modified="2009-03-03" version="1">MIAAVWKNRRISLENLPNPIIEKGDEVIIKVLASGICGTDLHVFSGKAYGKDGIIRGHEFSGRVVEVGKETKGIKVGDLVAVDPNITCGYCYFCKRGEVNLCENLIALGVDIDGGFAEYCIVPYKQLYVFSSKISPVEGAMMEPVACALHGIERLNIKSGDVVLIVGGGALGLILLQLAKLSGASKVFLVEKVEWKREIAKELGADVIISPEENVVEIIKENNKGRGVDVGIEAVGKGETVRLTLENVRRGGKVLIFGVSSPEDLISISTYDIYFKELTIMGSFVNPFTNSKALSLIEEGKINVKRVVSHEFPIEKIEEGIKMGLSGDALRVMITFKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZP4</accession>
    <name>TRPD_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpD</name>
        <name type="ordered locus">Dtur_0692</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583062.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352591.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
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            <begin position="1"/>
            <end position="336"/>
        </location>
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        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
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            <position position="226"/>
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        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <sequence length="336" mass="36993" checksum="B81445985FF24754" modified="2009-03-03" version="1">MVKEFLKKISEGKHLNFEEAREIVLSIDREEITEAQLGAILLGLRLKGENPEEIAGFVDVLHEKAKKVPNKTPAIDVCGTGGDKSNTFNISTAVAFTLASLGIKVAKHGNRAMSSKAGSIDVIEALGFKCSDNPEEIAKDIDDKGIGIIFAPYFHPVVGKAVKVRRELGIGTIFNMAGPMLNPANLSGQILGVYSEKVMHRMAEASLILKKDNILFYHGKDDGIDEISLSGKTVFAYLKNSKIDYFEFSPEDIGVKRYQREDFNGGDAQENAKILENIFKGRAKEAHIDIVAVNSAFALWVLGKVKEVKEGFDMVKDHIMKGKVYEYIETLRGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZQ6</accession>
    <name>B8DZQ6_DICTD</name>
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        <submittedName>
            <fullName evidence="3">ATPase associated with various cellular activities AAA_3</fullName>
        </submittedName>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
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            </authorList>
            <dbReference type="PubMed" id="28066333"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="40"/>
            <end position="170"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="292"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="314" mass="35842" checksum="8E2CCEE6FDBB6F31" modified="2009-03-03" version="1">MDVDRYVEFKEKVVKNVSKAIVGKEKIIELIAISFICGGHVLLEDVPGLGKTLMVKAFAKTIGGSFKRIQFTPDLLPSDLTGINFYNQKKGEFEFRPGPLFANVILADEINRATPRTQSSLLEAMEEKQVTVDGVTWKLPDPFMVLATQNPVETYGTFPLPEAELDRFFMRIKIGYPTREEEIEIINRNKKRDMLEDVESVVNFDEIEYLRNNFSNVKISREVLNYLLDIVEYTRNSDTILLGVSPRGSIALFKASQVYALFNGRDYVIPEDIKYLAPFILNHRIISMGASRTKDIYENINIIVDNVKVPLEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZR3</accession>
    <name>B8DZR3_DICTD</name>
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        <recommendedName>
            <fullName evidence="10">Maltose/maltodextrin transport system permease protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="12" type="ordered locus">Dtur_0711</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="ACK41996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0711"/>
    <dbReference type="EnsemblBacteria" id="ACK41996">
        <property type="protein sequence ID" value="ACK41996"/>
        <property type="gene ID" value="Dtur_0711"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0711"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.748"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_20_1_0"/>
    <dbReference type="InParanoid" id="B8DZR3"/>
    <dbReference type="OMA" id="DGHNSTK"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990060">
        <property type="term" value="C:maltose transport complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015423">
        <property type="term" value="F:ABC-type maltose transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042956">
        <property type="term" value="P:maltodextrin transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030156">
        <property type="entry name" value="MalF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035277">
        <property type="entry name" value="MalF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029345">
        <property type="entry name" value="MalF_P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032550">
        <property type="entry name" value="TM_PBP2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47314:SF1">
        <property type="entry name" value="PTHR47314:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14785">
        <property type="entry name" value="MalF_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16296">
        <property type="entry name" value="TM_PBP2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="267"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK41996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="505" mass="57968" checksum="49315CCF3916B8E9" modified="2009-03-03" version="1">MNLLMPFLPIIYAGIIVAIGTFFSYILSIIAGFVWGLIFFLVVFLFALLIVHPKSYPWRYIVPSFLLMFMFMIYPIIYTIQIAFTNYGTGHILTKTQVIEQLEKETFLPENTQNFEYEIYKAKTGEILLLFRDKSKNIYKIEDKKLIKIGEGDFPKEYSNYKIVPQTQKYGEISKLQNIKIELENDTFLQMSDLNTFSIYRQRYKYISTEDVLIDNLTGEKLIPKNGFFVRPNGQEILPGFVTNVGIENFIRLFKDERVSKPFLRVFIWNVLWATLTTFINFAFGLFLALLMNDKNLEFKGIYRTLLIVPWAIPSFISLLIWVGLLNTEVGVVNRILLSIFGVKIPWFLETKWARLALFVVNLWLGYPYAMTVCLGSLQSIPEELYEAAKVDGASYFQQLKTITLPLLLTAIGPLIVGTFAFNFNNFNVIYLLTGGKPPMADISSVAGTTDILISYTYKLAFEGGRGQDYGLAATISIIVFLIVALLSLLNFWISGMFKQEVRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZS5</accession>
    <name>B8DZS5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352622.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0724"/>
    <dbReference type="EnsemblBacteria" id="ACK42008">
        <property type="protein sequence ID" value="ACK42008"/>
        <property type="gene ID" value="Dtur_0724"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0724"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2805556_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="67" mass="7913" checksum="60A8BE2A377A2105" modified="2009-03-03" version="1">MRNLIINLIKLGLTFLVFLVIFKRVSFPSLIEILQGVKFIYFIPTFLLSLAFTILKIYKWHLLLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZV5</accession>
    <name>B8DZV5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Phosphate propanoyltransferase</fullName>
            <ecNumber evidence="3 6">2.3.1.222</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0756</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>phosphate + propanoyl-CoA = CoA + propanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:28046"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58933"/>
            <dbReference type="EC" id="2.3.1.222"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Polyol metabolism; 1,2-propanediol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PduL family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.222" evidence="3 6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583123.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352652.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0756"/>
    <dbReference type="EnsemblBacteria" id="ACK42038">
        <property type="protein sequence ID" value="ACK42038"/>
        <property type="gene ID" value="Dtur_0756"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0756"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.794"/>
    <dbReference type="eggNOG" id="COG4869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080676_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZV5"/>
    <dbReference type="OMA" id="EMRERPI"/>
    <dbReference type="OrthoDB" id="1156172at2"/>
    <dbReference type="UniPathway" id="UPA00621"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051144">
        <property type="term" value="P:propanediol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008300">
        <property type="entry name" value="PTAC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39453">
        <property type="entry name" value="PTHR39453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06130">
        <property type="entry name" value="PTAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010130">
        <property type="entry name" value="PduL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="201" mass="22364" checksum="C2D20A0029AA9B90" modified="2009-03-03" version="1">MKEVKVPIGVSARHVHLSQDDLERLFGKNYELHPLKPLSQPGQFAAEEEVELIGPKRSLKVRILGPVRKNTQVELALTDVIYLGLPTIPPVRDSGDIEGTPGIKMRGPLGEIEIPQGVIIAWRHIHTPENIAQELGLVDKQLVKVKVEGVRAITFENVLIRISNKFAWEFHIDTDEANAAMVKTGDKAIVIFEPVKIPQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZW7</accession>
    <name>B8DZW7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, conserved site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0768</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583135.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352664.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0768"/>
    <dbReference type="EnsemblBacteria" id="ACK42050">
        <property type="protein sequence ID" value="ACK42050"/>
        <property type="gene ID" value="Dtur_0768"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0768"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.805"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027829_2_1_0"/>
    <dbReference type="InParanoid" id="B8DZW7"/>
    <dbReference type="OMA" id="INWGRYG"/>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="432" mass="48884" checksum="DD5871DFC2692640" modified="2009-03-03" version="1">MELLRLEHITVSFTFPEGEITVLDDINFTVNEGDFIALLGPSGSGKSTILRVIAGLLKPNKGKVYYKGEEIKGVNPGVAMVFQNFALFPWLTVLENVELGLKAKGVPPEERKEKAIKAIDLIGLDGFENAYPKELSGGMKQRVGFARALVMEPDILLLDEPFSALDVLTAENLRNDLIELWIEKRIPTKAIILVTHSIEEAVYMADRIILLSKDPGRIIKEVRIDLPHWRDKKSQEFLDIVDEIYGVLTGKPVERIIAREKRPLHIPQASVGSITGLVELVNDLDGKADIYKLGEELLMDVEDLLPIIEACEILGFAEVKEGDLILTEAGKKFSEADVLERKEIFKEFAIEKVPFLKQIVKVLQSKSNHKVPRSFFLDLLKQHLSPQEAERELDILIDWGRYAELFEYDDDRDELYLPETSELLVNVQKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZY6</accession>
    <name>B8DZY6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583154.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352683.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0788"/>
    <dbReference type="EnsemblBacteria" id="ACK42069">
        <property type="protein sequence ID" value="ACK42069"/>
        <property type="gene ID" value="Dtur_0788"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0788"/>
    <dbReference type="eggNOG" id="COG3870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143974_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZY6"/>
    <dbReference type="OMA" id="TFMIGIE"/>
    <dbReference type="OrthoDB" id="2052224at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010375">
        <property type="entry name" value="CdAMP_rec"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38456">
        <property type="entry name" value="PTHR38456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06153">
        <property type="entry name" value="CdAMP_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="108" mass="12480" checksum="D94A5D8C9E4BBCE6" modified="2009-03-03" version="1">MKLVFAIIQEEDWKKVREIFIEHNFSLTFFKSKGGFLEEGSVTLMTVVDDDRFEEVLTILRENCKEREKMIIPPLPSVELLRTVPMPVKIKVGGAVVFAVDVSYFEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8E011</accession>
    <name>B8E011_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583178.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352708.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0813"/>
    <dbReference type="EnsemblBacteria" id="ACK42094">
        <property type="protein sequence ID" value="ACK42094"/>
        <property type="gene ID" value="Dtur_0813"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0813"/>
    <dbReference type="HOGENOM" id="CLU_569542_0_0_0"/>
    <dbReference type="OMA" id="FTGWINT"/>
    <dbReference type="OrthoDB" id="754526at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="479" mass="54035" checksum="4FBBB7511BE40907" modified="2009-03-03" version="1">MKKLIKGFLILFLVIFSIVILLALTSPWWAKSLVSYILEKNFGKYAKAEDVKYIFPNKVEISTLEVANFATFSNVSISLQNPLKLSPINIELTKPKMIIIHNEKGEWTFPQIPGIDTSKSNNANNISIEIKAKIKDGIVVVRDLKTEKDIEVQKVNGNLYWKNQMITYSVSTSINNQEIKSYGTYDFSKEEGNLTFEFKNALADVWAGVFLPNIFYIEKGYFTGWINTKGDKNDWVVSGEINAFNVEGRIASFTPKFVNVSTKVKIDGENINILDGRGNLWDADIKFLGKATPKPEMNISFESLNLEKIDKEFFKGSINLRGKAKGEFSISESWENAIIKGYIIAEKGSIYNFDFNNIKIDIDSKLPLVNAKILGDLDLGNLNGKISFDLKSTLINLNLEANNVKIEKIAEIFNLPKMEGKGDVTIEAKKDKKWKISVSGIIENGKLGDYSAESIEFNFENEDIDFNLPFGDSFFFQKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E022</accession>
    <name>B8E022_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="2">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583189.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352719.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0824"/>
    <dbReference type="CAZy" id="GT19">
        <property type="family name" value="Glycosyltransferase Family 19"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42105">
        <property type="protein sequence ID" value="ACK42105"/>
        <property type="gene ID" value="Dtur_0824"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0824"/>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023761_0_0_0"/>
    <dbReference type="InParanoid" id="B8E022"/>
    <dbReference type="OMA" id="LGGDQFW"/>
    <dbReference type="OrthoDB" id="497029at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="366" mass="43579" checksum="0B6275301EF359CB" modified="2009-03-03" version="1">MSKIYFLVNGPGEISGWLYPLIRWIKEFKPSWAESFSFNSIIVPCQFASGEEEKVLRSWNFFKEIIPSNKYWDLFKDRVKDENSVLFHIGGDLYFNFILSKRWNSIPIAYVEKYFWIEKFYKKVYTLRDIKLKNSIFVGDLRFDFLPKDAFADNNKIALFPGSRSYVLRFFIPFYLALVKELVKDFPDLNFTFFISPFVDERIVKDTLKKLQTLIKELPINFETLDDMNKLKGFLMAITLPGTNTLQLAYMKIPMMIILPLHKPDFIPLEGLANFLKGNLREKLIEFYLRKNPYLALPNQIYPGIVPEIVGKFQFREVLNYIKEILYNREKLKKINKIMEEKFNKDYLTSELIWKDLYYEILSKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E023</accession>
    <name>B8E023_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0825</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583190.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352720.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0825"/>
    <dbReference type="EnsemblBacteria" id="ACK42106">
        <property type="protein sequence ID" value="ACK42106"/>
        <property type="gene ID" value="Dtur_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0825"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.864"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_0"/>
    <dbReference type="InParanoid" id="B8E023"/>
    <dbReference type="OMA" id="HESFDGA"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="ACK42106.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="575" mass="64631" checksum="54F62B73ACF2060F" modified="2009-03-03" version="1"> </sequence>
</entry>
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="290" mass="33303" checksum="E21BA05F0318EACB" modified="2009-03-03" version="1">MESKEIKGFFILILVTFIWGSTFSFTKIALKVFTPFFLLFLRFLFGALFLFLFLKLKKQRISVNRSGIILGLINFSAIAFQTFGLQYTTATKTAFITGISILLVPFFEKFIFKNKIYWNLWLAVIIGFIGLIFLTTDFSVVSKINWGDFLVFICAVLYALQIVYISYVVEHREVFDLAFSEILFTAIFSFLFFLFFEPRNLPLYFIFQNSLPIVYLGVVATAFTLTLQLIGQKYVPPTKSALIYNLEPVFATLFAFILLSEKLTHLQIIGALLILMSLFISIPSSFQNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Gowda K."/>
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            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="37790" checksum="05EC162321EBADAD" modified="2009-03-03" version="1">MNFEYFLRLYGRERKYEFKAKNVREWEDWKTNFRKDLIRILGEFPESSDFKLEILEKSKLRNICVEKIKFNSSKDIEVIGYVLTPEINLPAPFVIAVPGHGVGAKDAVFGDSSGYMKNFGVLLAQSGFLTFVIEQLGFGERREEKDIEEREDKSSCRTYAFWALMQGKTLIGLRVWDIIRTIDLFLENFEIKSDAIGIYGISGGGTTALFTSAIDDRIKATVISGYLNTFRDSILSMSHCECNYIPGILEYGEMYDIASLIAPRFLFIEHGKKDPIFPIESTVFAFKKIKEVYDFLGVSENIDCEFFDGGHEIYANKSIFWLKRILQGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0B3</accession>
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    </organism>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
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    <comment type="similarity">
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    <dbReference type="EnsemblBacteria" id="ACK42558">
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    </dbReference>
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    </dbReference>
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    <feature type="chain" id="PRO_1000128740" description="50S ribosomal protein L27">
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            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <sequence length="84" mass="9279" checksum="5CC75133102F9737" modified="2009-03-03" version="1">MAHKKSGGASRNGRDSNPKYLGVKRFEGQLVEAGNILVRQRGTKIYPGMNVGMGRDFTLYALQPGIVKFSIKHGKKYVNVLSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0B9</accession>
    <name>B8E0B9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
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    <organism evidence="2 3">
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            <taxon>Dictyoglomales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583646.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353178.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42564">
        <property type="protein sequence ID" value="ACK42564"/>
        <property type="gene ID" value="Dtur_1286"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1286"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1328"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555216_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0B9"/>
    <dbReference type="OMA" id="DHAYSVI"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02608">
        <property type="entry name" value="delta_60_rpt"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870892" evidence="1">
        <location>
            <begin position="25"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="400" mass="43027" checksum="9B5D2D57B9FDEEC9" modified="2009-03-03" version="1">MRKFFLLLSVFLIFSLLISGCAPKKDTTPPQQVWQKTYGGSSSDYAYSIQQTSDGGYIVAGYTWSFGAGNRDFYIIKLDSNGNKVWEKTYGGSNDDWARSIQQTSDGGYIVVGGTYSFGAGYADFYIIKLDSNGDKVWEKTYGGSENDVARSIQQTSDGGYIVAGGTSSFGAGGDFYIIKLDSNGNKVWEKTYGGSDDDWASSIQQTSDGGYIVAGGTYSFGAGSADFYIIKLDSNGDKVWEKTYGGSSWDRASSIQQTTDGGYIVAGYTNSFGAGNGDFYIIKLDSNGDKVWEKTYGGSSYDEAYSIQQTSDGGYIVAGYTESFGAGYSDFYIIKLDSNGDKVWEKTYGGSNDDEASSIQQTTDGGYIVAGGTYSFGAGGDFYIIKTDSEGNTGPYPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0C1</accession>
    <name>B8E0C1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583648.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353180.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42566">
        <property type="protein sequence ID" value="ACK42566"/>
        <property type="gene ID" value="Dtur_1288"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1288"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1330"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555216_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0C1"/>
    <dbReference type="OMA" id="GNMKWEK"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17164">
        <property type="entry name" value="DUF5122"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02608">
        <property type="entry name" value="delta_60_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="401" mass="43320" checksum="64DC87DFD4CB543F" modified="2009-03-03" version="1">MRKFFLLLSVFLIFFLLISGCAPKKDTTLPQQVWQKTYGGSDSGDEASSIQQTNDGGYIVAGWTSPLATGSYYVYIIKIDSNGNMKWEKTFGGSNADWAFSIQQTIDGGYIVAGRTSSLGAGSYDVYIIKLDSNGNMKWEKTFGGSDWDEAFSVQQTSDEGYIVAGRTNSFSKGEGDVYIIKLDSNGNMKWEKTFGGSSDDYALSIQQTSDGGYIVAGVTWSFGAGSADFYIIKLDSKGDEVWEKTYGGSSSDYACSIQQTSDGGYIVAGYTNSFGAGYGDVYIIKLGSNGNMKWEKTFGGSSDDRAYSIQQTSDGGYIVAGVTWSFGAGDVYIIKLDSNGNKVWEKTFGGSNDDWANSIQQTKDGGYIVAGYTNSFGAGYGDFYIIKTDSEGNTGPYPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0C7</accession>
    <name>B8E0C7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583654.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353186.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1295"/>
    <dbReference type="EnsemblBacteria" id="ACK42572">
        <property type="protein sequence ID" value="ACK42572"/>
        <property type="gene ID" value="Dtur_1295"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1295"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1338"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_0_0"/>
    <dbReference type="InParanoid" id="B8E0C7"/>
    <dbReference type="OMA" id="RALHPMM"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="13"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="99" mass="11435" checksum="DF8B0236D6F8DA1E" modified="2009-03-03" version="1">MNKKLQNIIKTIESLKDKIKRDYKAEIVGIFGSYVRGEQKRGSDLDLLVKFYDGATLFEFVGLAIFLEEKLGIKKVDIVPYDTVKSEIRDKIFNEAIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0D0</accession>
    <name>B8E0D0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Positive regulator of sigma E, RseC/MucC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583657.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353189.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1301"/>
    <dbReference type="EnsemblBacteria" id="ACK42575">
        <property type="protein sequence ID" value="ACK42575"/>
        <property type="gene ID" value="Dtur_1301"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1301"/>
    <dbReference type="eggNOG" id="COG3086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124911_2_1_0"/>
    <dbReference type="InParanoid" id="B8E0D0"/>
    <dbReference type="OMA" id="SEACHSC"/>
    <dbReference type="OrthoDB" id="2059963at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026268">
        <property type="entry name" value="RseC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007359">
        <property type="entry name" value="SigmaE_reg_RseC_MucC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35867">
        <property type="entry name" value="PTHR35867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004923">
        <property type="entry name" value="RseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="136" mass="15439" checksum="4F30EC356A19D890" modified="2009-03-03" version="1">MKEIGQVIEKNGIILKVKFSSSEACHSCGLCKINEEDLVLDVIDECNAKIGDFVMVEVERKDFYQVTFLIYLFPLISFILGVLIGYLIGERYRLDTQLLGLSIGLVFTVLSYPLIKSIYKKLSQKQKFIPVAKKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0D1</accession>
    <name>B8E0D1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Subunit of 2-oxoglutarate:ferredoxin oxidoredutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583658.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353190.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1302"/>
    <dbReference type="EnsemblBacteria" id="ACK42576">
        <property type="protein sequence ID" value="ACK42576"/>
        <property type="gene ID" value="Dtur_1302"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1302"/>
    <dbReference type="HOGENOM" id="CLU_2568352_0_0_0"/>
    <dbReference type="OMA" id="APNYIIG"/>
    <dbReference type="OrthoDB" id="2145339at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="81" mass="9330" checksum="87CF16AD98BEE1C4" modified="2009-03-03" version="1">MFKDFTPPKGYRILKIAPNYIIGELIYNLLVSEGFHPQILSSSFPYTDPVYMGRGLPVYVIIPEGEFEEAQKILESQNFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0E6</accession>
    <name>B8E0E6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583673.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353205.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1317"/>
    <dbReference type="EnsemblBacteria" id="ACK42591">
        <property type="protein sequence ID" value="ACK42591"/>
        <property type="gene ID" value="Dtur_1317"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1317"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1362"/>
    <dbReference type="eggNOG" id="COG0232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028163_1_1_0"/>
    <dbReference type="InParanoid" id="B8E0E6"/>
    <dbReference type="OMA" id="HCKAFRR"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="75"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="345" mass="40264" checksum="A5D0BEEC1C73162D" modified="2009-03-03" version="1">MTIREKLEEREKLFLSPYATLSCNSKGRLFFEEECSIRTRFQRDRDRIIHSKAFRRLKHKTQVFLAPEGDHYRTRLTHTLEVSQIARTIARALFLNEDLTEAIALGHDLGHTPFGHMGEDVLDEISKSYGLLGFSHAEQSLRIVDRLENNGKGLNLTYEVRMGILQHSKGQQDFRKCFGSRVCETLEAEVVRFSDVIAYLNHDLDDAIRAGVIREKDIPKKVLDVLGRTHRERINTMVQNLVANSINKDRLVFDSEILDAIEEMRAFLYEKLYVNPHVKSENDKVKLLLTGLFEYFMKNPQKLPQNLSEEENIIIKIRDFLAGMTDRYAIELYENVFIPKPWRFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0E8</accession>
    <name>SYGB_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyS</name>
        <name type="ordered locus">Dtur_1319</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583675.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353207.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0E8"/>
    <dbReference type="SMR" id="B8E0E8"/>
    <dbReference type="STRING" id="515635.Dtur_1319"/>
    <dbReference type="PRIDE" id="B8E0E8"/>
    <dbReference type="EnsemblBacteria" id="ACK42593">
        <property type="protein sequence ID" value="ACK42593"/>
        <property type="gene ID" value="Dtur_1319"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1319"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1364"/>
    <dbReference type="eggNOG" id="COG0751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007220_2_2_0"/>
    <dbReference type="InParanoid" id="B8E0E8"/>
    <dbReference type="OMA" id="LPIPKRM"/>
    <dbReference type="OrthoDB" id="213210at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000197185" description="Glycine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <sequence length="689" mass="80746" checksum="78DB16219F7BB779" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0K1</accession>
    <name>RL10_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplJ</name>
        <name type="ordered locus">Dtur_1372</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583726.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353260.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0K1"/>
    <dbReference type="SMR" id="B8E0K1"/>
    <dbReference type="STRING" id="515635.Dtur_1372"/>
    <dbReference type="EnsemblBacteria" id="ACK42646">
        <property type="protein sequence ID" value="ACK42646"/>
        <property type="gene ID" value="Dtur_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1372"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1417"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_2_0_0"/>
    <dbReference type="InParanoid" id="B8E0K1"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000120951" description="50S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <sequence length="178" mass="20208" checksum="C0DA04EADC8B2098" modified="2009-03-03" version="1">MPKPEKIQKVEELYQKMLNANALIFTEFKGLSVADLTQLRGKIRPLNAEYRVVKNTLALRAIQRMYPDKDLEKFFVGPTAITYCYDDPFGVLKALVDYAKDHELLKFKGGIIDGEVYSADEIRELAKLPPKEVILSQVVGSISAPLSSLVWNLKWPVNKLVWTLDAIAKEKEKISINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0L8</accession>
    <name>B8E0L8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalamin biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584113.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353652.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1766"/>
    <dbReference type="EnsemblBacteria" id="ACK43038">
        <property type="protein sequence ID" value="ACK43038"/>
        <property type="gene ID" value="Dtur_1766"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1766"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174500_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0L8"/>
    <dbReference type="OMA" id="HLMTERK"/>
    <dbReference type="OrthoDB" id="2075561at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="6">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK43038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="113" mass="12657" checksum="E97B9896A939D203" modified="2009-03-03" version="1">MSNWKRLFIGILILVLLSPIGIILPTLLNAGSAWGEWGPEELKEMIGYVPKGIEKLSSLAKPLFPDYNIKGWEDKDVLYQSIGYIISGIVGVLVVILITYVIGRWSVKKKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0M3</accession>
    <name>B8E0M3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584118.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353657.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1771"/>
    <dbReference type="EnsemblBacteria" id="ACK43043">
        <property type="protein sequence ID" value="ACK43043"/>
        <property type="gene ID" value="Dtur_1771"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1771"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1823"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0M3"/>
    <dbReference type="OMA" id="GICEFKE"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK43043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="252" mass="27123" checksum="F7DD5404848D2AB1" modified="2009-03-03" version="1">MNFKGKVVLITGAGSGIGRKTAIMFAERGAKVAVNDISEEKGKETVEIIKNNGGEAIFILGDVSSPKDAERIIKEVVENFGKIDILVNNAGIVVYGKVEDTSEEDFDKTMLVNVKGPFFLSKYAVLEMKKQGGGVIVNVSSEVALKAIPERCVYSMSKGALISLTKSMAIDYARENIRVNAVCPGTTFTQGLAERLKKLPNADEVLKQMSERRPIGRLGKEEEIAFAILFAACDEAGYMTGSIISIDGGFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0N7</accession>
    <name>B8E0N7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7" type="primary">argJ</name>
        <name evidence="8" type="ordered locus">Dtur_1785</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584131.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353671.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1785"/>
    <dbReference type="MEROPS" id="T05.002"/>
    <dbReference type="EnsemblBacteria" id="ACK43057">
        <property type="protein sequence ID" value="ACK43057"/>
        <property type="gene ID" value="Dtur_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1785"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1837"/>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0N7"/>
    <dbReference type="OMA" id="DYVHENS"/>
    <dbReference type="OrthoDB" id="1083409at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023323774" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023323773" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="186"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK43057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="389" mass="42273" checksum="BA9D31C36B2EE2A4" modified="2009-03-03" version="1">MSWKTEKLYLTNIKGVKAAAVSCGLKEDNKLDLALIVLDKPAKATAMFTRNTVKAAPVIVSKKHLEKYGLVQAIIINSGQANACTGGRGIKDAEFMAEEVAKRVGIEKELVFVASTGKIGAYLEKEKIAYGIELAYKNLSENSGESIAEAIMTTDTFPKISGAKRGDAVISGVAKGAGMIHPNMATMLAFIGTNVKLGSEELKRVLKKSVDKSFHQISVDGCSSTNDTVLLFSTGEVLDKTFQKGLDMVAQDLAKMIARDGEGAKKLIEVIVEKARSLKEAKVIARSVVVSNLVKAAIAGGDDNWGRVLASIGQTEYSFDLNKIELYIGDHLVFAKNEPLGYNSQEVKNYLKGNEVRIRIILNEGRYSAISWGCDLTEEYVKINAYYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Q2</accession>
    <name>B8E0Q2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosidase PH1107-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584146.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353686.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1800"/>
    <dbReference type="EnsemblBacteria" id="ACK43072">
        <property type="protein sequence ID" value="ACK43072"/>
        <property type="gene ID" value="Dtur_1800"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1800"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1852"/>
    <dbReference type="eggNOG" id="COG2152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046648_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0Q2"/>
    <dbReference type="OMA" id="KAVQMNI"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016202">
        <property type="entry name" value="PH1107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="331" mass="37865" checksum="215FD643CC834093" modified="2009-03-03" version="1">MGKYQIIGEKIPNLPWEDRPKGSSDIVWRYSKNPIIKRNHIKRANSIFNSAVVTFNGKFAGVFRVDDKARSMNLHAGFSEDGINWVIEEEPINFIQKTRDPLISEYKYDPRVTFIEDRYYITWCNGYYGPTIGVGYTFDFKEFYQLENAFLPYNRNGVLFPRKINGKYAMLSRPSDRGHTPFGDIFYSESPDMIHWGCHRFVMSAGLTGWQSLKIGAGPTPIETSEGWLLIYHGVLLSCNGYVYSFSAALLDLEKPWKVKYRARSYLLSPQEYYECVGDVPNVAFPCAALCDSETGRLAIYYGGADTVVALAFAYVDEIIDFLKEDGIKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0R5</accession>
    <name>B8E0R5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584159.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353699.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1814"/>
    <dbReference type="EnsemblBacteria" id="ACK43085">
        <property type="protein sequence ID" value="ACK43085"/>
        <property type="gene ID" value="Dtur_1814"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1814"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_4_0"/>
    <dbReference type="InParanoid" id="B8E0R5"/>
    <dbReference type="OMA" id="AEVCVMP"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="225" mass="26010" checksum="8020DE58B6A66AFE" modified="2009-03-03" version="1">MEVKKFLKNVPLFEDFSDEELEKLLVISKEKTYPKDAVIFQKGDLGNFFFLICSGRVKVIIETEEGKEGILSILYPTEFFGEMSLLDGEPRSATVVALEETRVIIIERNDFLILLYKHPELALKILKTLSLRLRKANRQIETLMFLDAPGKVARLLIDIAQERGKKINNEILIDLEFTRQELGNLIGVSRETTTRILKSFEEDGILSIERNQVIIKDVWELKRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0S1</accession>
    <name>B8E0S1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583736.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353272.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1384"/>
    <dbReference type="EnsemblBacteria" id="ACK42658">
        <property type="protein sequence ID" value="ACK42658"/>
        <property type="gene ID" value="Dtur_1384"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1384"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1430"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_330589_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0S1"/>
    <dbReference type="OMA" id="GWNNFKR"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="656"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="690"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="750"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="784"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="870" mass="101539" checksum="BAB4732908D7D91F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0S9</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">Dtur_1392</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42666.1"/>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_002353280.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1392"/>
    <dbReference type="EnsemblBacteria" id="ACK42666">
        <property type="protein sequence ID" value="ACK42666"/>
        <property type="gene ID" value="Dtur_1392"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1392"/>
    <dbReference type="eggNOG" id="ENOG5030SN0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2025657_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0S9"/>
    <dbReference type="OMA" id="QGLKHYR"/>
    <dbReference type="OrthoDB" id="1685553at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="99" mass="11491" checksum="96C21C969BF090B8" modified="2009-03-03" version="1">MDKESILKGLDGFSKLAKQDMLMSVHTENPEYWRKNAEARHDKYKELYKLVEEVGLDMAIEKTIEEYKSLKEENDPVARGKKRALESFFVLVGIDPSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0W3</accession>
    <name>B8E0W3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42700.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="ACK42700"/>
        <property type="gene ID" value="Dtur_1426"/>
    </dbReference>
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        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
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    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
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        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glyco_transf_4"/>
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    </dbReference>
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        <property type="entry name" value="Glycos_transf_1"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="536" mass="62134" checksum="5DD22AA64CDD2F40" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Z4</accession>
    <name>AROK_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shikimate kinase</fullName>
            <shortName evidence="1">SK</shortName>
            <ecNumber evidence="1">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroK</name>
        <name type="ordered locus">Dtur_1457</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583809.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353345.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0Z4"/>
    <dbReference type="SMR" id="B8E0Z4"/>
    <dbReference type="STRING" id="515635.Dtur_1457"/>
    <dbReference type="EnsemblBacteria" id="ACK42731">
        <property type="protein sequence ID" value="ACK42731"/>
        <property type="gene ID" value="Dtur_1457"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1457"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1507"/>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057607_4_3_0"/>
    <dbReference type="InParanoid" id="B8E0Z4"/>
    <dbReference type="OMA" id="IGKHLFE"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000117459" description="Shikimate kinase">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <sequence length="172" mass="20343" checksum="E005BF68B991E2B1" modified="2009-03-03" version="1">MRSSLSFVGFMGSGKTSIGKRISLFFNIPFLDLDEYIEKKLKKSISDIFIEKGEEYFRNIETESLREAFSLYPKIVLSTGGGVVLREENRRILREKSKVIYLKGEFENLMKHLENKEEHEKRPLLKKGREELYNLWKKRLPLYESCADIIVEVDNKDIDEITFEIIERLRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E184</accession>
    <name>B8E184_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="5">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">asnS</name>
        <name evidence="7" type="ordered locus">Dtur_0931</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583296.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352826.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0931"/>
    <dbReference type="EnsemblBacteria" id="ACK42212">
        <property type="protein sequence ID" value="ACK42212"/>
        <property type="gene ID" value="Dtur_0931"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0931"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.968"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_0"/>
    <dbReference type="InParanoid" id="B8E184"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="6">
        <location>
            <begin position="133"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="433" mass="50559" checksum="2558E9E0908B2F44" modified="2009-03-03" version="1">MAASWVYIEDIPRIQEGEVEIRGWLFNKRSSGKIVFLIIRDGTGYIQGVATLDNFTEEELDSFEKIPIESSLIVVGDLRREPRAPGGYELLLKRVNIVSYSEDYPIQKKDHSVDFLLERRHLWIRSRKQNAILRIRSEVVKAIRDFLDEKGFVLIDAPILTPSSCEGTTTLFSLDYFDLGKAYLSQSGQLYMEAACMAFGKVYCFGPAFRAEKSKTRRHLTEFWMVEPEMAFWDWQDNMKLQEELVSYIVQRVLEKRKRELEILERDTKPLEKVVPPFPRITYREAIEILKRNGQDIEYGDDFGGDEETIISNQFDKPVFIHHYPAKIKPFYMQPDPENPNEVLNNDLLAPEGYGEIIGGSQRIHDLKLLEKKLEEYNLPREVFEWYLDLRRYGSVPHSGFGLGIERTVAWICGLKHVREAIPFPRMIYRIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1A6</accession>
    <name>B8E1A6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA-binding S4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583318.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352848.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0953"/>
    <dbReference type="EnsemblBacteria" id="ACK42234">
        <property type="protein sequence ID" value="ACK42234"/>
        <property type="gene ID" value="Dtur_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0953"/>
    <dbReference type="eggNOG" id="COG2302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1072539_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1A6"/>
    <dbReference type="OMA" id="KFYMEIE"/>
    <dbReference type="OrthoDB" id="1477108at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="1">
        <location>
            <begin position="182"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="259" mass="29715" checksum="72229064ED6C7484" modified="2009-03-03" version="1">MGQKIDELFLEIKDKKIKEKVRELYDVFQKVAQKGGLYVTGFLSLTEQYYFQRISGYFTNELYTSLYGGVDGAERKRGFISDKIELIEYIDYNKYLVGISINPEEKISISFLKEIFEKNVLLDKVGDIWYSDGIKMVLASETLFEVQKILGENNINFELLTLDQLKTYSKATRIIRTTESSKRLDSIGGAALGISRSKMQTYIKAGVVTVNGKKVADTHYELEEGDVVIVQELGNFKINKINVTPKGKFYMEIERSLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1B1</accession>
    <name>B8E1B1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583323.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352853.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0959"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42239">
        <property type="protein sequence ID" value="ACK42239"/>
        <property type="gene ID" value="Dtur_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0959"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1B1"/>
    <dbReference type="OMA" id="DDGANPF"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="388" mass="44945" checksum="26B7F559EF3DC6A8" modified="2009-03-03" version="1">MKIAFFTNNYLPNTGGAAIAVESYRDALEKLGHEVYIFAPKYPPWFPKYKDNVSERIWRFPSFAIKFITPQPIPIYFAFLVEDFFKKQKFDIVHSHHPFVIGKTALKLAKKYHIPIVFTHHTQYHKYVHYIPLVPEKISAKIAIKESVKYANQVDLVIAPTKEIKDMIINFGVKTRIEILPTGIDLSMWEEPIQEEFLRNFPWKEKRILLYAGRLAKEKNIEFIFTSLEKLLKKREDIILLVVGDGDERKNLENLVKRLNLEDKIVFMGWHPREELVNFYKIAEIFVFASTTETQGLVTLEAMAGGCAIVAIKAPGSMSLIEDGKEGFLVKEDPEEFANKVELLLNNRNLLATMQNNAKIKAREFSIDKSAMKLVEFYKELAKIKEKQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1D7</accession>
    <name>RS19_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsS</name>
        <name type="ordered locus">Dtur_0985</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583349.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352879.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1D7"/>
    <dbReference type="SMR" id="B8E1D7"/>
    <dbReference type="STRING" id="515635.Dtur_0985"/>
    <dbReference type="EnsemblBacteria" id="ACK42265">
        <property type="protein sequence ID" value="ACK42265"/>
        <property type="gene ID" value="Dtur_0985"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0985"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1022"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1D7"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000127967" description="30S ribosomal protein S19">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <sequence length="94" mass="10777" checksum="84843B7A29A9301A" modified="2009-03-03" version="1">MGRSLKKGPYVDPKLLKKIRELNEKGEKKIIKTWSRRSVIVPEMVGHTIAVYNGRKHIPVYITENMIGHRLGEFAPTRTFTGHRIPTARITAIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1E8</accession>
    <name>RL6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplF</name>
        <name type="ordered locus">Dtur_0996</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583360.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352890.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1E8"/>
    <dbReference type="SMR" id="B8E1E8"/>
    <dbReference type="STRING" id="515635.Dtur_0996"/>
    <dbReference type="EnsemblBacteria" id="ACK42276">
        <property type="protein sequence ID" value="ACK42276"/>
        <property type="gene ID" value="Dtur_0996"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0996"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1033"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1E8"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000143980" description="50S ribosomal protein L6">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <sequence length="180" mass="19792" checksum="E2C411F5D684862E" modified="2009-03-03" version="1">MSRIGRKPVPIPQNVQVEIKDGNCVSVKGPLGQIEKTFSPLLTIKKVDNQIVVERPNDEKFVKALHGLTRALINNMVLGVTQGFEKRLELQGTGYRARVQGNKLVLEVGFSHPVELEIPTGLTVSVQDNTKISVKGIDKELVGQFAAIVRSVRPAEPYKGKGIRYEGEKIRQKAGKAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1F3</accession>
    <name>B8E1F3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="10" type="ordered locus">Dtur_1001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583365.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352895.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1001"/>
    <dbReference type="EnsemblBacteria" id="ACK42281">
        <property type="protein sequence ID" value="ACK42281"/>
        <property type="gene ID" value="Dtur_1001"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1001"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1038"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1F3"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009132">
        <property type="term" value="P:nucleoside diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009123">
        <property type="term" value="P:nucleoside monophosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
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            <begin position="128"/>
            <end position="163"/>
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            <begin position="32"/>
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            <begin position="12"/>
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        <ligand>
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        <ligand>
            <name>AMP</name>
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        <ligand>
            <name>AMP</name>
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        <source>
            <dbReference type="RuleBase" id="RU003330"/>
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        <source>
            <dbReference type="RuleBase" id="RU003331"/>
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        <source>
            <dbReference type="Pfam" id="PF05191"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACK42281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="215" mass="24661" checksum="29208BD1016D10D1" modified="2009-03-03" version="1">MMKAIIFLGPPGAGKGTHAKEVSQILNIPHISTGDIFREHVKNQTDLGIKVKSYLDAGKLVPDEVVWEVVKDRIDKEDCKNGFILDGFPRTILQAEMLEKYLKEKNADIKVIYLDAPDELVIRRLSARRVCKNCGAIYNLISMPPKKDGICDICGGELYQRSDDKPEVIKQRLETYYKETQPLIDYYKNKDIMYTINAEKEREEVLKEILKVINE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1G1</accession>
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            <fullName evidence="1">50S ribosomal protein L17</fullName>
        </recommendedName>
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        <name evidence="1" type="primary">rplQ</name>
        <name type="ordered locus">Dtur_1009</name>
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            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
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        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
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        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
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    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
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            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
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</entry>
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            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
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        <name evidence="1" type="ordered locus">Dtur_0175</name>
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            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="SBP"/>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="ACK41506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="458" mass="51837" checksum="5BF6995889992A47" modified="2009-03-03" version="1">MKKIFVFILLFLLVFLGSEVFAQKKIILKLGMWPEPTLKSDVEMFEKWKKEFEKKYPNVQVVPATYKYSPDTFVPLAESGNLPTIFETWFTEPQKLIAGGFVKDITNELKKKGWDTLMNPSVKQILSKNNRIYGVPRDAYALGMYLNLELFEKAGLMNPDGTPKYPKTWDELAKAAKIIKDKTGRAGFCLLAKDNAGGWHFTQIAWNFGAKLEVQKNGKWYANLNSPEVVTAMNFVKDLKWKYDVLTDDPTSEDWGSGFEAIATGRAAMYLGAQDAVNQPTQVYGMSIDKLAIVPVPAGPKGHHYSLMGGTPYMFSAKASSDEVMAALNFLEIMGKAPIVTPESLAGMRADAENRVKNGVPVIPSFPAWIAKDWLKAQEEIVKQYRNVDMRLYNDYYNWIKKPNVLRPEEPYLTQDMYAELTKVLQAVVSDKNADVKKLLDIANNNLQKMLDMYVNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1K2</accession>
    <name>B8E1K2_DICTD</name>
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        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">Dtur_0198</name>
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    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352141.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0198"/>
    <dbReference type="EnsemblBacteria" id="ACK41527">
        <property type="protein sequence ID" value="ACK41527"/>
        <property type="gene ID" value="Dtur_0198"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0198"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.204"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_0"/>
    <dbReference type="InParanoid" id="B8E1K2"/>
    <dbReference type="OMA" id="AKDANTM"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="276" mass="29403" checksum="F490F7737928BF21" modified="2009-03-03" version="1">MSYIEELFSVKDKVAFFTGGGGILASAISEGLGKAGAKIVLTDINEKALMAQVEKLKSMGITAEGFVMNALEKENVKEVAEKVKNMFGKIDILLNAAGGNIPEAVTSDKVTFWDLPVESIQKVVNINLFAGAIIPSQIIGKMMVENPDGGVIINFASMSSFRPLTRVVGYSAAKAAVANFTQWLAVYVAKEFSPKVRVNAIAPGFLITNQNRYLLLNEDGSLTPRGKAVIEHTPMGRFGEPEELIGTIIWLASPASSFVTGAVIPIDGGFNAFSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1K8</accession>
    <name>B8E1K8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582618.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352147.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0204"/>
    <dbReference type="EnsemblBacteria" id="ACK41533">
        <property type="protein sequence ID" value="ACK41533"/>
        <property type="gene ID" value="Dtur_0204"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0204"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.212"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034528_1_1_0"/>
    <dbReference type="InParanoid" id="B8E1K8"/>
    <dbReference type="OMA" id="FPYPVYA"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870582" description="Phosphate-binding protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="5">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="342" mass="37771" checksum="D277837B20797DD6" modified="2009-03-03" version="1">MKKWFLILMILLISSGAFGQQVVINGAGATFPYPLYSRWFYEFEKETGIKINYQSVGSGAGIQQAKAGTVDFGASDAPLPGKEQEESKLVMIPTVAGSIAIVYNLPNVEKGLKLTRELIADIYLGKVKRWDDPKIKAFNKDINLPNIPIVVARRSDGSGTTAIFTNFLSAVSPEWKEKVGAGTSVNWPVGIGGKGNEGVAGIVKNTIGAIGYVEFAYAVQNNLNYAQIKNKYGTFVYPSIETVKYAASFFKLPEDFAVYIVDAPGKNSYPIAGYTFLLLKREYQDLEKAKAIIKFITWAYEKGDKYAEELLYVPLPDNVKKLALKKLELITYKGKKVVDLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1L0</accession>
    <name>B8E1L0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582620.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352149.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0206"/>
    <dbReference type="EnsemblBacteria" id="ACK41535">
        <property type="protein sequence ID" value="ACK41535"/>
        <property type="gene ID" value="Dtur_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0206"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_3_0"/>
    <dbReference type="InParanoid" id="B8E1L0"/>
    <dbReference type="OMA" id="TALFMEN"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="446" mass="49775" checksum="411FA73E8BEC9CAB" modified="2009-03-03" version="1">MIGNSESKREIVISVLIASFLTSFIGSAINIAIPVMGKEFKLNNVALTWLNTSFQLSAATFLLTFGKLADIKGRRELYYLGIFIFAFGVFLSIFSMSYSFLLLSRIIQGIGSSIIFATSSAILTSLYPQRRGYILGIYTTLVYLGLSFGPILGGFLTQYVGWKGIFVFTLILSILSMILGLFYRERESKREEKLDIWGTILFSSFVFLFLFGTAQILKPMGIISTIAGIIILLLFYFLERKVKDPLIDVELLINNKNFTFANITALINYASTFGVSFLLSLYLQNIKGISPRDAGLFLIFQPLTQALFSSWAGRLSDKKRPEILASTGMFIIGIFLFLLSKLSPRSPIFLIPIYGTFLGFGFALFSSPNTNIVMGSVDKKDYGFASSFLATMRVIGQSLSMVMVSLIFSLNNDLMNSYGTLMIIYGILCFVGVFLSIKRHEVRKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1L1</accession>
    <name>B8E1L1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582621.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352150.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0207"/>
    <dbReference type="EnsemblBacteria" id="ACK41536">
        <property type="protein sequence ID" value="ACK41536"/>
        <property type="gene ID" value="Dtur_0207"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0207"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.216"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141525_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1L1"/>
    <dbReference type="OMA" id="MPEFANP"/>
    <dbReference type="OrthoDB" id="1833195at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="99" mass="11439" checksum="2C6EC7EBDAC7FE56" modified="2009-03-03" version="1">MPEFGTPYSVLGVGRKISKEELIRAIRLFVAAEYEAIQLYEEIAEATNDPLAKKVLYDIANEEKVHAGEFLTLLKELDKEEENFYKKGEKEVEEMKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1M0</accession>
    <name>B8E1M0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0216</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582630.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352159.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0216"/>
    <dbReference type="EnsemblBacteria" id="ACK41545">
        <property type="protein sequence ID" value="ACK41545"/>
        <property type="gene ID" value="Dtur_0216"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0216"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_0"/>
    <dbReference type="InParanoid" id="B8E1M0"/>
    <dbReference type="OMA" id="HTRILFR"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="74"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="280" mass="30654" checksum="EF7A9EC274CFC167" modified="2009-03-03" version="1">MWKQMIRPLFKSPKFIVGATIFLLIVLMAILGPIVYPKDPTSFAGIPEQPPSKQYPLGTDTYGGDLLAKVLNGTRSSLYIGFLVAIISMSIGLLVGTFSAIKGGIIDDILMGLTNIVLTIPSILLAILIASYLNIRSLEVIAVILGILSWPWFARAIRAQLMSLINREYVYLSRLAGYGDFRLAIEDLIPAIATYTFMAFILFINGGILGEAGLSLIGLGPTKGVTLGIVLQWAVLMEAIRRGLWWWFIPPGVIIVALTSSLLIITTAMDEVFNPKLRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1N6</accession>
    <name>B8E1N6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352175.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0232"/>
    <dbReference type="EnsemblBacteria" id="ACK41561">
        <property type="protein sequence ID" value="ACK41561"/>
        <property type="gene ID" value="Dtur_0232"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0232"/>
    <dbReference type="HOGENOM" id="CLU_057665_0_0_0"/>
    <dbReference type="OMA" id="SQYNFDK"/>
    <dbReference type="OrthoDB" id="2114403at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="292" mass="33266" checksum="50F5DE1916933D04" modified="2009-03-03" version="1">MKTLLILFLFLLFLNLVYSFPKDISKAINNANKENKQEVKSQRIINNKSKILEDNLSSENLKKERISQEEYNKERIEDLEKPKSLEEFLSQYNFDKNTLKNNKVKTSSEKSNEEKESNLNKNEEQKGSKEASIDSSNLPTSAGRNQAFLDQTSKSSLKEPTGEKEEGSTLENNNPPEMSLKDRMLQNPSPGEGLQENTKQTGSLPGTEERETKLGEAESQRRVFSGEKIYVPPSLSEKEGKNYLFQAPTLEGRRKASGSNINLNPSYEEENPTASRILPKEFQEILKLYFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1P3</accession>
    <name>B8E1P3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase/Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352182.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8E1P3"/>
    <dbReference type="EnsemblBacteria" id="ACK41568">
        <property type="protein sequence ID" value="ACK41568"/>
        <property type="gene ID" value="Dtur_0242"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0242"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.253"/>
    <dbReference type="eggNOG" id="COG4099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035499_3_0_0"/>
    <dbReference type="InParanoid" id="B8E1P3"/>
    <dbReference type="OMA" id="WVFHAED"/>
    <dbReference type="OrthoDB" id="1195966at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041172">
        <property type="entry name" value="EstA_Ig-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18435">
        <property type="entry name" value="EstA_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EstA_Ig_like" evidence="2">
        <location>
            <begin position="40"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="280"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="412" mass="46874" checksum="872F023316F7FEB3" modified="2009-03-03" version="1">MLPALFFLTLFCGGIIFTNYAVFVEGKMSEVLTPHNIPRATIVTRVMPEGERVVAVVLEYDAEINAGNLNLNMFSVKTKLEGKFVERSIKKVYANNNGELLPAPFTNQGRFLVLELNPKEPSAVTATFDPQRFLSKRLKLEYEIEQKVSIKSVDGKEIMPFSLITSEERHLIIDEFKALIYEDKDLGVILPYRFYVPKNIDKNKKYPLVVFLHGAGERGNDNFLHIAWYRGAVTFAEPGQQAEHPCFVLAPQCPADSSWTELLMRGNPFKPTKTLLAVANLIRKIISEENIDSNRIYLTGLSMGGFGTFALLIEHPELFAGAIPICGGADINNLERIRDIPLWIFHAEDDNLVSVEFSRSVVKRLVEIGGKVKYTEFLWGEMERMGYHPHASWIPVYDNEEVIDWLFEQRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1P4</accession>
    <name>B8E1P4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9 10">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="3 9 10">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Dtur_0243</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9 10">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="3 9 10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352183.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0243"/>
    <dbReference type="CAZy" id="CBM36">
        <property type="family name" value="Carbohydrate-Binding Module Family 36"/>
    </dbReference>
    <dbReference type="CAZy" id="GH11">
        <property type="family name" value="Glycoside Hydrolase Family 11"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41569">
        <property type="protein sequence ID" value="ACK41569"/>
        <property type="gene ID" value="Dtur_0243"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0243"/>
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    <sequence length="356" mass="39472" checksum="6E6551B6961DCA5F" modified="2009-03-03" version="1">MFKVYLEKLTKLLLIMLLIAVYTQVHAQTSITLTSNASGTFDGYYYELWKDSGNTTMTVYTQGRFSCQWSNINNALFRTGKKYNQSWQSLGTVKITYSATYNPNGNSYLCIYGWSTNPLVEFYIVESWGTWRPPGATSLGQVTIDGGTYDIYRTTRVNQPSIVGTATFDQYWSVRTSKRTSGTVTVTDHFRAWANKGLNLGTIDQITLCVEGYQSSGSANITQNTFSTSSSSGGSTTVTRVECENMSLSGPYASRISSPFNGVALYANNDRAYYTQYFANSVHTFRLRGCSSNNNTAAVDLRIGGQKVGTFYFTGTTPTVQTLSNISHATGNQTVELILTSDNGTWDVYLDYLEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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            <dbReference type="PubMed" id="28066333"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACK41573.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="586" mass="65673" checksum="97335AC1CA39A310" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Q5</accession>
    <name>B8E1Q5_DICTD</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0254</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0254"/>
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        <property type="gene ID" value="Dtur_0254"/>
    </dbReference>
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    <dbReference type="OMA" id="DFFLIPY"/>
    <dbReference type="OrthoDB" id="803820at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867790" evidence="1">
        <location>
            <begin position="20"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="799" mass="93138" checksum="F3D7B0BD1AF3CFF6" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Q9</accession>
    <name>Y258_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein Dtur_0258</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_0258</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582669.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352198.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1Q9"/>
    <dbReference type="SMR" id="B8E1Q9"/>
    <dbReference type="STRING" id="515635.Dtur_0258"/>
    <dbReference type="EnsemblBacteria" id="ACK41584">
        <property type="protein sequence ID" value="ACK41584"/>
        <property type="gene ID" value="Dtur_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0258"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.271"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1Q9"/>
    <dbReference type="OMA" id="MGNMMKQ"/>
    <dbReference type="OrthoDB" id="1883809at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000119317" description="Nucleoid-associated protein Dtur_0258">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="104" mass="11378" checksum="84746284089F3886" modified="2009-03-03" version="1">MKNPFEAMKQLKKLQEKMAKIEEELEQTLVEGTAGGGVVKIVMTAKEEVKEVKIDPEVVNKDEVDILEDLIAAALRDALTKAKEKSAEKMGSLTDGLPLPPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1R8</accession>
    <name>B8E1R8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582786.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352315.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0397"/>
    <dbReference type="EnsemblBacteria" id="ACK41701">
        <property type="protein sequence ID" value="ACK41701"/>
        <property type="gene ID" value="Dtur_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0397"/>
    <dbReference type="eggNOG" id="ENOG5032WVJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128779_0_0_0"/>
    <dbReference type="OMA" id="VSEIMAF"/>
    <dbReference type="OrthoDB" id="1992913at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="146" mass="16226" checksum="BED8ADC67F34F4EA" modified="2009-03-03" version="1">MKKCVFLIVVILLSFSITYAGNFGVGVVVGEPTGLSFRLWQNKTQAFDFGVAWSLNANVLHLFADVVTHNYGVFRPTSGSMPFYYGVGVRVLSAESTNFGIRIPLGIVYIPKGTNLDFFFELVPTLELVPQTTLDVDGSFGFRYYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1S8</accession>
    <name>B8E1S8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582796.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352325.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0407"/>
    <dbReference type="EnsemblBacteria" id="ACK41711">
        <property type="protein sequence ID" value="ACK41711"/>
        <property type="gene ID" value="Dtur_0407"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0407"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.429"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_10_1_0"/>
    <dbReference type="InParanoid" id="B8E1S8"/>
    <dbReference type="OMA" id="GILDMIH"/>
    <dbReference type="OrthoDB" id="762291at2"/>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="18"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="255" mass="28088" checksum="1E26AB0053387021" modified="2009-03-03" version="1">MLLQGKKIAVFNVANKKSIAWAIAQSIMKFGGEVIIGYQNERLKENVEELIADLNPKPLIVECDVSKDENIEKVAKEIENNVGKIDGFVHSIAFAPSDALKNPYIETSREAFLTAMEVSVYSFVAMSRIFKPILNTNSSIITLTYYGSEKVIPNYNVMGVAKAALEASVRYLAYDLGGENIRVNAISAGPLSTLAARGIARFTDMLEYHKERAPLRRNIEHREVGDTAVFLLSNLSSGITGEVIYVDAGYNIMGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1U2</accession>
    <name>B8E1U2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582810.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352339.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0422"/>
    <dbReference type="EnsemblBacteria" id="ACK41725">
        <property type="protein sequence ID" value="ACK41725"/>
        <property type="gene ID" value="Dtur_0422"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0422"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.446"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1U2"/>
    <dbReference type="OMA" id="ITGGRNW"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="265" mass="28992" checksum="B692A8AD8998A130" modified="2009-03-03" version="1">MCDCQRLKNRVAIVTGAAQGLGEALSYRLAKEGCNVTVADIKVEKLQEVAKRIEEEYGSKALAVKCDVTNEEDVKNMVEKTVETFGKLDIMVANAGILIAHDITEFPLEDWKKVIDVNLTGYFLCAREAAKVMVKQKSGVIIQINSKSGKKGSFRNAAYSASKFGGIGFTQSIALDLAPHNVRVVAVCPGDLLDSPLWKESLYDQYAKRLGISKEEVRERYLKQIPLGRACTYDDVANVVVFLASDEASYITGDAVNVSGGVEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1V3</accession>
    <name>B8E1V3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582821.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352350.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0434"/>
    <dbReference type="EnsemblBacteria" id="ACK41736">
        <property type="protein sequence ID" value="ACK41736"/>
        <property type="gene ID" value="Dtur_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0434"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.458"/>
    <dbReference type="HOGENOM" id="CLU_849243_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="327" mass="36927" checksum="DD1CBB7FAF91759B" modified="2009-03-03" version="1">MKKIVYLFILLLIIVPVYAQTSISTKVEFSMKYYPDSQKINFNPNYYLYCNFKDLNISAFIDMRDSGFKGGYLSLTNIGNILDIYFAKYYISVEGTKALWDSLLYNRLNLNGIQITLKTPVKLTLTYLPSLIESDVAFNTGRLVLKAQTDVLSKFLGLNLYGLYDMNMQMTVNTFLVGAEVKPLSFLSLFFEYGNNSRNWAVGGTIKPVNNITLSGYYRGDGGYNVEASISDIIPKLSLYGAYYSAPDSPNYVYGRIVLPPLPFGNIDALFGQYTSLSTSYVWYVRLSSSWGKVSNTLRFYKGWSFGAGWFDTTIPTTLEEVVSVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1X5</accession>
    <name>B8E1X5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">4Fe-4S ferredoxin iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582843.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352372.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0457"/>
    <dbReference type="EnsemblBacteria" id="ACK41758">
        <property type="protein sequence ID" value="ACK41758"/>
        <property type="gene ID" value="Dtur_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0457"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.482"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_5_5_0"/>
    <dbReference type="InParanoid" id="B8E1X5"/>
    <dbReference type="OMA" id="DKCIQCY"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="78" mass="8548" checksum="090E941DE25C2C79" modified="2009-03-03" version="1">MSKTWYPVINYEKCIGCLACVNFCPHGVYDVKDKKPIVVRPEECVDFCKGCLKGACPTGAISFVGDKVKIMTDGGELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Z7</accession>
    <name>B8E1Z7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582865.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352394.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0482"/>
    <dbReference type="EnsemblBacteria" id="ACK41780">
        <property type="protein sequence ID" value="ACK41780"/>
        <property type="gene ID" value="Dtur_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0482"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.507"/>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084161_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1Z7"/>
    <dbReference type="OMA" id="QHVHIHN"/>
    <dbReference type="OrthoDB" id="1994547at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019698">
        <property type="term" value="P:D-galacturonate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd11613">
        <property type="entry name" value="SAF_AH_GD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044144">
        <property type="entry name" value="UxaA/GarD_SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="2">
        <location>
            <begin position="12"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="93" mass="10647" checksum="25FD903B5CD2C485" modified="2009-03-03" version="1">MNHKFLVHHEKDNVGVAVADIKKGEKVKGYYLEGGKWIELEALDDIPLGHKIALQDLSEKDLIIKYGEVIGEAVKEIKKGEHVHIHNIKSRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E251</accession>
    <name>B8E251_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1048</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583411.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352942.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1048"/>
    <dbReference type="EnsemblBacteria" id="ACK42328">
        <property type="protein sequence ID" value="ACK42328"/>
        <property type="gene ID" value="Dtur_1048"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1048"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1085"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_1_0"/>
    <dbReference type="InParanoid" id="B8E251"/>
    <dbReference type="OMA" id="PWIRVRE"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="46"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="184" mass="21490" checksum="CF95A6DBB661D39E" modified="2009-03-03" version="1">MIEEVKIELEEKIIEESEKYKGRIITVKEYRVVLINGKETKREVVHHPGAVAILPILEDGSLFFVKQYRLPAKKILLEIPAGKLDQGENPEECAYRELEEEIGYVPGNLRLIHTFYPSPGISNEILYLFEATNLRKTKNNPDEDEFLEVITLNKEEVKRYLFENRFEDSKTLIGVYYYLYSRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E268</accession>
    <name>B8E268_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligopeptide binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583428.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352959.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1065"/>
    <dbReference type="EnsemblBacteria" id="ACK42345">
        <property type="protein sequence ID" value="ACK42345"/>
        <property type="gene ID" value="Dtur_1065"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1065"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3889">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010991_1_0_0"/>
    <dbReference type="InParanoid" id="B8E268"/>
    <dbReference type="OMA" id="YNDTRYE"/>
    <dbReference type="OrthoDB" id="63045at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002871067" evidence="1">
        <location>
            <begin position="27"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="37"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="701" mass="81001" checksum="8EAA0C590CF8CF09" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E275</accession>
    <name>B8E275_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferric uptake regulator, Fur family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583435.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352966.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1073"/>
    <dbReference type="EnsemblBacteria" id="ACK42352">
        <property type="protein sequence ID" value="ACK42352"/>
        <property type="gene ID" value="Dtur_1073"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1073"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_2_0"/>
    <dbReference type="InParanoid" id="B8E275"/>
    <dbReference type="OMA" id="YLYGVCT"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900376">
        <property type="term" value="P:regulation of secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="133" mass="15590" checksum="352F2A05E15FDFB7" modified="2009-03-03" version="1">MQRETRQRRLIMEILLNSMDHPDALTVFRRAQDKKAKVSIGTVYRTLELLVKEGKALKFYDANAIARYDAKTDFHHHLICKICGKVEDLDVSLFKSDQMIKEIEEKTHFKDIEYHLTIYGICEDCAKRGNRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E279</accession>
    <name>B8E279_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS</name>
        <name evidence="11" type="ordered locus">Dtur_1077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583439.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352970.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1077"/>
    <dbReference type="EnsemblBacteria" id="ACK42356">
        <property type="protein sequence ID" value="ACK42356"/>
        <property type="gene ID" value="Dtur_1077"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1077"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1113"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_1_3_0"/>
    <dbReference type="InParanoid" id="B8E279"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="15991at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
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        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_MISMATCH_REPAIR_2" evidence="10">
        <location>
            <begin position="688"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="725"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="614"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="853" mass="98641" checksum="099E0EF412FCA63F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E298</accession>
    <name>B8E298_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ion-translocating oxidoreductase complex subunit B</fullName>
            <ecNumber evidence="5">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Rnf electron transport complex subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rnfB</name>
        <name evidence="8" type="ordered locus">Dtur_1096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 3 [4Fe-4S] clusters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583458.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1096"/>
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        <property type="protein sequence ID" value="ACK42375"/>
        <property type="gene ID" value="Dtur_1096"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1096"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1132"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="term" value="F:electron transfer activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="RsxB_RnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4Fe-4S_dom"/>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
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        <property type="entry name" value="Elect_transpt_cplx_RnfB/RsxB"/>
    </dbReference>
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        <property type="entry name" value="Fer4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12798">
        <property type="entry name" value="Fer4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01944">
        <property type="entry name" value="rnfB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S" evidence="7">
        <location>
            <begin position="32"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
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            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
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            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="237"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Hydrophobic" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
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        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="266" mass="27611" checksum="AD439EF0E759DB27" modified="2009-03-03" version="1">MGLVLISVIVLGAIGLLFGIGLAIAGEKFKVEVDPRITEILNVLPGANCGACGYPGCEGFAKAVVEGRAPYTGCVVGGEKVAKNIAKILGVDENITMVKSVAFLTCQGGKGIAQEKYVYKGVDTCKAANLVQGGYKGCPTGCLGFGDCVKACPFDAIHMGEDGLPKIDMEKCTGCGLCVKACPRGILTLLPVDIPLLLGCKTELPGPEARRVCSKACIGCGICEKVCPKGAIKMDGRFPVIDYNLCDGCGICVEKCPTKALILLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2A2</accession>
    <name>B8E2A2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583462.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352993.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1100"/>
    <dbReference type="EnsemblBacteria" id="ACK42379">
        <property type="protein sequence ID" value="ACK42379"/>
        <property type="gene ID" value="Dtur_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1100"/>
    <dbReference type="eggNOG" id="COG2177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029472_0_0_0"/>
    <dbReference type="OMA" id="QIWENIF"/>
    <dbReference type="OrthoDB" id="1653234at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="9">
        <location>
            <begin position="51"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="270" mass="31507" checksum="792BAC827E2D7FA7" modified="2009-03-03" version="1">MSGAKEFWEGIKSKGIFLYLGFIILYVVFFAIVIFITAMNGSLNMWIEKIKIYAFINSKTPDSQILKLIDDLKNNFHIKEINYITQKDAWEKLKEIIGRENDIFAWGSPDNLPKALEITPLILDNIENILSFVMNYNFVEEVRYSEDMVNQWHKLNNLINCIKKLFIYLGSFAFLIISVELLAHAHLAFPNFSVPSQIWENIFVTFTSSVIAFLLIFLISSSIKSYIIVYLPYFEFIFDLRHSLVWVLYFILSSIIVSFTSALISFQRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2B5</accession>
    <name>B8E2B5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583475.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353006.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1113"/>
    <dbReference type="EnsemblBacteria" id="ACK42392">
        <property type="protein sequence ID" value="ACK42392"/>
        <property type="gene ID" value="Dtur_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1113"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069129_1_2_0"/>
    <dbReference type="InParanoid" id="B8E2B5"/>
    <dbReference type="OMA" id="ACGKGRH"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="43"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="252" mass="30030" checksum="57C4972232AF8AAE" modified="2009-03-03" version="1">MEENKDWRDIYFSRDYYLYLAKHLTPERTRKEVDFLESTLAIKRGYLILDLGCGFGRHTLELGKRGYRAIGIDRSEDLIEIAKEEAKKEKVFNVEFYIMEYKDIEKLGYKFDVVFSLYTSFGLSTYEEDKEAIEKVYNILKKGGKFLIDIENRDALLRYFIPYSWDILNDYILLTEHHFEPESGYYISNRLVFDLKNNTKKEFVRKIYLYTPSEIAHILEEKGFTIEKFIGDYDGKRFHIGSRRLIVVGTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2F6</accession>
    <name>B8E2F6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">topA</name>
        <name evidence="12" type="ordered locus">Dtur_1526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583876.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353414.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1526"/>
    <dbReference type="EnsemblBacteria" id="ACK42800">
        <property type="protein sequence ID" value="ACK42800"/>
        <property type="gene ID" value="Dtur_1526"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1526"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1575"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_0"/>
    <dbReference type="InParanoid" id="B8E2F6"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="164"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="696" mass="80945" checksum="CF0D08AC19FE8488" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2G3</accession>
    <name>RL19_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplS</name>
        <name type="ordered locus">Dtur_1533</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583883.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353421.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2G3"/>
    <dbReference type="SMR" id="B8E2G3"/>
    <dbReference type="STRING" id="515635.Dtur_1533"/>
    <dbReference type="EnsemblBacteria" id="ACK42807">
        <property type="protein sequence ID" value="ACK42807"/>
        <property type="gene ID" value="Dtur_1533"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1533"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1582"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_1_0"/>
    <dbReference type="InParanoid" id="B8E2G3"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000193827" description="50S ribosomal protein L19">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <sequence length="118" mass="13820" checksum="93DCDD59229BD361" modified="2009-03-03" version="1">MDLIIQNLEKEYMKKDIPEIWPGDTVRVHYRIVEGDKERIQVYEGVVIAKKHGGIRETITVRKVVQGVGVERIFPLHSPLVEKIEVVRRGRVRRAKLYYLRERKGKSAKIAEREENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2H8</accession>
    <name>B8E2H8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583897.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353436.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1548"/>
    <dbReference type="EnsemblBacteria" id="ACK42822">
        <property type="protein sequence ID" value="ACK42822"/>
        <property type="gene ID" value="Dtur_1548"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1548"/>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1616374_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2H8"/>
    <dbReference type="OMA" id="LCEYLAM"/>
    <dbReference type="OrthoDB" id="1760549at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="160" mass="18950" checksum="FE843336278D9A70" modified="2009-03-03" version="1">MPDSLYSKLWEVFIKLNLEKKLCEYLAMDKWEEVVGETLSQHTKPAYVREGVLYVYVDSSVWVQELSLFKDKLIEKLNSSMIIPHVIKDIVFIDKGRAFKKFKKKEIKREIKLSLQEEQRIAKIVEDIKDEELREILRNYYRSIALIRKGGIKNGGNKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2I3</accession>
    <name>B8E2I3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FeS assembly ATPase SufC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Ycf16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583902.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353441.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1553"/>
    <dbReference type="EnsemblBacteria" id="ACK42827">
        <property type="protein sequence ID" value="ACK42827"/>
        <property type="gene ID" value="Dtur_1553"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1553"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1602"/>
    <dbReference type="eggNOG" id="COG0396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_48_1_0"/>
    <dbReference type="InParanoid" id="B8E2I3"/>
    <dbReference type="OMA" id="MAMLEPK"/>
    <dbReference type="OrthoDB" id="1214676at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="250" mass="28564" checksum="10E53C843FFED7F9" modified="2009-03-03" version="1">MKEVLKKEMLRLENLKVKVKDEVILENINLSLNEGVHVLLGPNGTGKSTLLGAIMGLSKYKVSGKIWFYNEDITELSPDQRFKKGIFLAYQLPPAVRGVRLKDILKKILNIDPKKSLPDEVYTYLRELDLDESFLEREINYGFSGGERKKSEILQLLLAKPKLAMLDEPDSGVDIDSLKLIGENLRKISKESNLLIVTHNLKILDYVNTDSVVVLLDGKYIYKDGIEIIHQIEERGYEYVRRLAYAQNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2K9</accession>
    <name>B8E2K9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YHS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583928.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353467.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1579"/>
    <dbReference type="EnsemblBacteria" id="ACK42853">
        <property type="protein sequence ID" value="ACK42853"/>
        <property type="gene ID" value="Dtur_1579"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1579"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1627"/>
    <dbReference type="eggNOG" id="COG3350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185152_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2K9"/>
    <dbReference type="OrthoDB" id="1964436at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="1">
        <location>
            <begin position="4"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="48" mass="5622" checksum="3E9F56047E823AF7" modified="2009-03-03" version="1">MAKDPVCGMEVDERNPPAVSEYKGKKYYFCNKACKIEFDKDPEKYVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2L5</accession>
    <name>B8E2L5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cellulase</fullName>
            <ecNumber evidence="7">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583934.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353473.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1586"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42859">
        <property type="protein sequence ID" value="ACK42859"/>
        <property type="gene ID" value="Dtur_1586"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1586"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018668_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2L5"/>
    <dbReference type="OMA" id="LVDDWTQ"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006073">
        <property type="term" value="P:cellular glucan metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005102">
        <property type="entry name" value="Carbo-bd_X2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016282">
        <property type="entry name" value="Glyco_hydro_5_endoGlcnase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03442">
        <property type="entry name" value="CBM_X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001043">
        <property type="entry name" value="Endoglucanase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Cellulase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="CBM_X2" evidence="6">
        <location>
            <begin position="362"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="545" mass="63913" checksum="E1B1CF2CB005BE41" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2P4</accession>
    <name>Y1615_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transcriptional regulatory protein Dtur_1615</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_1615</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583963.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353502.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2P4"/>
    <dbReference type="SMR" id="B8E2P4"/>
    <dbReference type="STRING" id="515635.Dtur_1615"/>
    <dbReference type="PRIDE" id="B8E2P4"/>
    <dbReference type="EnsemblBacteria" id="ACK42888">
        <property type="protein sequence ID" value="ACK42888"/>
        <property type="gene ID" value="Dtur_1615"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1615"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1664"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_0"/>
    <dbReference type="InParanoid" id="B8E2P4"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000132189" description="Probable transcriptional regulatory protein Dtur_1615">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <sequence length="249" mass="27329" checksum="0B43B379F9C81A15" modified="2009-03-03" version="1">MSGHSKWANIKHRKAAADAKKGKLFSQLSKEIIIAAKHGGGNPETNPRLRAAIERAREANMPKENIEKAIMRGTGEIPGVAYEEVTYEGYGPGGVAIMVEVVTDNKNRTAAEIRRIFTKHGGNLGEAGCVAWIFEEKGSIIIEKESVKDEDQLISDALEAGAEDVQISDDTVEVITSPESFSEVRDILKEKGYKITQAEVTKVPKNLVPVDGPDAEKVLKLMEELEDHDDVQKTYANFDIPDEILQSLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2S5</accession>
    <name>PNP_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polynucleotide phosphorylase</fullName>
            <shortName evidence="1">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pnp</name>
        <name type="ordered locus">Dtur_1146</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583507.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353039.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2S5"/>
    <dbReference type="SMR" id="B8E2S5"/>
    <dbReference type="STRING" id="515635.Dtur_1146"/>
    <dbReference type="EnsemblBacteria" id="ACK42425">
        <property type="protein sequence ID" value="ACK42425"/>
        <property type="gene ID" value="Dtur_1146"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1146"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1183"/>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_0"/>
    <dbReference type="InParanoid" id="B8E2S5"/>
    <dbReference type="OMA" id="LHILDVM"/>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000185736" description="Polyribonucleotide nucleotidyltransferase">
        <location>
            <begin position="1"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="552"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="621"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <sequence length="693" mass="76821" checksum="A0F962C980F2976D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2V8</accession>
    <name>B8E2V8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583540.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353072.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1179"/>
    <dbReference type="EnsemblBacteria" id="ACK42458">
        <property type="protein sequence ID" value="ACK42458"/>
        <property type="gene ID" value="Dtur_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1179"/>
    <dbReference type="HOGENOM" id="CLU_1068462_0_0_0"/>
    <dbReference type="OMA" id="FAIWMSV"/>
    <dbReference type="OrthoDB" id="2110269at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="260" mass="29826" checksum="234E32C80D081FF2" modified="2009-03-03" version="1">MKKGMSLVELIISLFILFIILALTFAIWMSVQRDFISQKLDREIYEYLNSAKTNILDSVLKSIFIYPPNVNIRLSDSSNFNLNINERIGYDKLLTITPASSGGYFLNVYLTRPRVPTDSALPNARMLLYYRKFINWSPQYATYTITVAFTGTSKTLKIGKITNYPTNITFTSGEFPKIIADYIVPNGFTVSYYVIDYSTLDPSNNTYSLTTYTDTIPSRNTNIQQVQVSLSIQRRYQNIVRTRDVTFNGTVFLEELPISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E307</accession>
    <name>B8E307_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tadA</name>
        <name evidence="5" type="ordered locus">Dtur_1229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583589.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353121.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1229"/>
    <dbReference type="EnsemblBacteria" id="ACK42507">
        <property type="protein sequence ID" value="ACK42507"/>
        <property type="gene ID" value="Dtur_1229"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1229"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1269"/>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_3_2_0"/>
    <dbReference type="InParanoid" id="B8E307"/>
    <dbReference type="OMA" id="LSMSINT"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="156" mass="17981" checksum="4FD2CC215DFD9F57" modified="2009-03-03" version="1">MDKKFSSIDEYFMHEAIKEAKKALRKGEVPVGAVIVYNGQIVGRGYNLRESKKNPISHAEMIAIEKAAKKLKGWRLCNCTLYVTLEPCIMCFGAILNSRISRLVYGTENREEGFTQFVNIRDYKKWKDIEIISGIKKDVCESLLKEFFKDMRSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E322</accession>
    <name>B8E322_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583604.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353136.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1244"/>
    <dbReference type="EnsemblBacteria" id="ACK42522">
        <property type="protein sequence ID" value="ACK42522"/>
        <property type="gene ID" value="Dtur_1244"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1244"/>
    <dbReference type="HOGENOM" id="CLU_1400566_0_0_0"/>
    <dbReference type="OMA" id="YIPWGIY"/>
    <dbReference type="OrthoDB" id="2118539at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="194" mass="23507" checksum="961B2D3ADA2EC39C" modified="2009-03-03" version="1">MKKFLLVFFILLIVISSTWILYIRIDPKVDELLNVIRKDLKFRNILFVSLLVPKIEQKYNLIITKISYIPWGIYVRYDEAKTFLYVEFNKKNYYYNQKFAIMKKYAPFDGTIKIEGTNDIGLIQDILRNFGFFRIHRIKFYDKYFEIYGEDCILKISLEDYQEKKRYIMDIVKNFNLKGKTLDFRFRIPFIGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E364</accession>
    <name>B8E364_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide-transporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584013.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353552.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1666"/>
    <dbReference type="EnsemblBacteria" id="ACK42938">
        <property type="protein sequence ID" value="ACK42938"/>
        <property type="gene ID" value="Dtur_1666"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1666"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1716"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_3_1_0"/>
    <dbReference type="InParanoid" id="B8E364"/>
    <dbReference type="OMA" id="FRTQAVQ"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="327" mass="34545" checksum="0CBD42588441D32A" modified="2009-03-03" version="1">MKEGVKSKRLIKTGRIQELGILVILFLLSLFLSLTTETFLTSTNIFNILRAFSWIAISGFGILMVIITGGIDLSVGSVMAMAGLITAMMLKANFGVFLSILGGIFIGGLIGFINGILISKTNLPPFIATLGTMNIARGFCYGVTGGWPVRDLPKSFNFLGQYDVPFLGVGIPLPVIFMIILGVITSIFLNRTSWGYKIYAVGGNEQAARLSGINTGRIKILVYTLCGVLTAIGGILMTARLGVAAPTAALGYELDVIAAAVIGGASLAGGEGTVLGVIIGAAIMQVLRTGMVLLGFPAYWQPSAIGAIIIAAIIFDQYRKRKMGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E375</accession>
    <name>B8E375_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584024.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353563.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1677"/>
    <dbReference type="CAZy" id="GH4">
        <property type="family name" value="Glycoside Hydrolase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42949">
        <property type="protein sequence ID" value="ACK42949"/>
        <property type="gene ID" value="Dtur_1677"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1677"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1727"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_0_1_0"/>
    <dbReference type="InParanoid" id="B8E375"/>
    <dbReference type="OMA" id="NEHASHI"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019802">
        <property type="entry name" value="GlycHydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01324">
        <property type="entry name" value="GLYCOSYL_HYDROL_F4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="8">
        <location>
            <begin position="190"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="416" mass="47606" checksum="011E18AF67BB928D" modified="2009-03-03" version="1">MKVVVIGGGSTYTPELIEGFFDIWDKVDSLEIVLMDIDENRLNIVYEFLKRMIHKVKAKIDLKKSTDLDKILPGADFIINQIRVGGNKARLLDETIPLEFNLLGQETTGPGGFANALRTIPVVYNIAKKVENYAPNSYFINFTNPSGIITEMLLNYTKVKAIGLCNVPINFQKFFADLAEVDMKEVFLDYFGLNHLSFVRRIFVRGEDRTSELLEKAKEKASDSEKKIIDYLKMFPNYYLRYYYFREEMVEELKHKPKRAEEVMKVEEDLLKLYQDPNLDTKPMELSKRGGALYSKAAVNLISHLYGLQEGFQIINVRNDGSILDLPQDSVVEIPVYVQKDRFHRYVIGGLPIEVRGLIQAVKVYERLTIEAAMEGSYKKALLALSQHPLISSLSLSEKLLNKLIEVNKGLFPELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E376</accession>
    <name>B8E376_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584025.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353564.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1678"/>
    <dbReference type="EnsemblBacteria" id="ACK42950">
        <property type="protein sequence ID" value="ACK42950"/>
        <property type="gene ID" value="Dtur_1678"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1678"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1728"/>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_0"/>
    <dbReference type="InParanoid" id="B8E376"/>
    <dbReference type="OMA" id="EHDGFAH"/>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="2">
        <location>
            <begin position="51"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="3">
        <location>
            <begin position="198"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="284" mass="31998" checksum="072C27ADEC39FD12" modified="2009-03-03" version="1">MRIEDFENNQIPAWCPGCGNWSILNCLKRVLSELEIKPKDLLMVSGIGQAAKAPHYFKCNLFNGLHGRDIPAAVGAKIANKDLIVICESGDGNTYGEGGNHLIHNIRRNLNIKVFVHNNQIYGLTKGQASPTSDQGMKTKVQPLGVPYKPLNPIALAISQGASFVARSFSGDPDHLVEMMKQAILHKGFALLDILQPCVTFNRINTYQWYKERIYKLGPDYDPTDVMKAFEKSLEWGNKIPIGIIYKNERQTFEEILPQLKGEPLYKKVRSPVEVFEKIVKEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E393</accession>
    <name>B8E393_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584042.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353581.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1695"/>
    <dbReference type="EnsemblBacteria" id="ACK42967">
        <property type="protein sequence ID" value="ACK42967"/>
        <property type="gene ID" value="Dtur_1695"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1695"/>
    <dbReference type="eggNOG" id="COG3339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139031_0_0_0"/>
    <dbReference type="InParanoid" id="B8E393"/>
    <dbReference type="OMA" id="PRVPWYA"/>
    <dbReference type="OrthoDB" id="2017850at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="6">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="120" mass="14050" checksum="15B120BA0C8C3BC6" modified="2009-03-03" version="1">MKNKVKNIKRKLKILYLFYKDPTVPLIKKFPAIILLGYTLSPIDLIPDFIPILGYLDDYIILPIGIYLCYKLIPQDKLKKYEEIIEKQDPSLKKNWISGVIILLIWIIILGILLKRLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3A2</accession>
    <name>B8E3A2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1704</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584051.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353590.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1704"/>
    <dbReference type="EnsemblBacteria" id="ACK42976">
        <property type="protein sequence ID" value="ACK42976"/>
        <property type="gene ID" value="Dtur_1704"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1704"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1755"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8E3A2"/>
    <dbReference type="OMA" id="VACHWAE"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="336" mass="37952" checksum="72BC57099313F7A1" modified="2009-03-03" version="1">MNNLLLEVKNLKKYFPITKGFLRKRVATVRAVDDISFFVREGETLGLVGESGCGKTTTGKVILRAYDPTDGDVILHVDGTEINVAKLSQKELKSVRRYMQMIFQDPFRSLNPRMTVRDIIGEPLIVNNVAKGKELDERIADLMRKVGLRPEYMKRYPHAFSGGQRQRISIARALALNPKLVICDEPVSALDVSIQAQVLNLLIDLQQEFKLTYLFISHDLSVVEHICDRVAVMYVGKIVELAKTEEIFENPKHPYTEALLSAVPKPDPKMKTHRILLKGEVPDASNPPSGCYFHPRCSYAKDICKEVRPELIDIGNEHYVACHFAKELNLKGIPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3B4</accession>
    <name>B8E3B4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584063.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353602.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1716"/>
    <dbReference type="EnsemblBacteria" id="ACK42988">
        <property type="protein sequence ID" value="ACK42988"/>
        <property type="gene ID" value="Dtur_1716"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1716"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056905_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3B4"/>
    <dbReference type="OMA" id="TWRLIVH"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045761">
        <property type="entry name" value="ODP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19583">
        <property type="entry name" value="ODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="371" mass="43506" checksum="3BA4ECAA4DC7C046" modified="2009-03-03" version="1">MPLKVTKIDEYITAIQTPDYPFTSNSYLITLKNKEEKINILVDPIPQEFFKDLVLSLKDLIGGVENIDIIFLNHQDPDVSSSVAPLMDMSKNTILITSEDTWRLVRFYGLNRERFQPIEYFPNRRVILKTDDTLEFIHTPFCHFRGAWMLYIPERKALFSGDLLGGLSSREVNGIYANEDSWEGIKLFHEIYMPSKEALKLAIDKIGRLTPLPELILPQHGDIIRKNLILDFLSRLNDLDVGLDYIKKYESQHQIYLFAFNEILQNLKNSYQNRDKLMQKLKELNSSPFFPELIHFENGVATEFRIQPESALELLFEKFKEDATLEEKENLRIDIIKTLRKYNLDIPEGILTEKQKTTENPLRRLFKIFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3C9</accession>
    <name>B8E3C9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584078.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353617.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1731"/>
    <dbReference type="EnsemblBacteria" id="ACK43003">
        <property type="protein sequence ID" value="ACK43003"/>
        <property type="gene ID" value="Dtur_1731"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1731"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1783"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="InParanoid" id="B8E3C9"/>
    <dbReference type="OMA" id="QYIYQMA"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="301" mass="34701" checksum="54A07D49C8939BA6" modified="2009-03-03" version="1">MKSKLFSKKLWWELGNWGFLLPHLFFFLLFIVIPLITNIQISFHNWNLLGQKVYVGLQNYIRIWTDDRFWLAVKNTVIFAIISIPLTMAVAMIIALILNQKVYGKLWLLVAFVSPTFFGSVGILTTWKWIYASYPTGLANYALLKLGFLKEAISWFETPTRAWACIIITTVWWIVGFSVLLYLGALQRIPPEQYEAAKVDGAGPWKTFWNITLPWMRNVLFFDVVRQVLLAFGLFDQVYFFTGGGPAGSTRTMVYYLYLVGFTRQELGQAAAISWYIFAIVLIFALLQLILLTRTVRSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3D1</accession>
    <name>B8E3D1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">L-fucose isomerase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584080.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353619.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1733"/>
    <dbReference type="EnsemblBacteria" id="ACK43005">
        <property type="protein sequence ID" value="ACK43005"/>
        <property type="gene ID" value="Dtur_1733"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1733"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045643_1_0_0"/>
    <dbReference type="InParanoid" id="B8E3D1"/>
    <dbReference type="OMA" id="CNAPIKP"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008736">
        <property type="term" value="F:L-fucose isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015888">
        <property type="entry name" value="Fuc_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02952">
        <property type="entry name" value="Fucose_iso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fucose_iso_C" evidence="2">
        <location>
            <begin position="350"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="496" mass="56020" checksum="66BC5615F8DB2A98" modified="2009-03-03" version="1">MKNVPDIKLGIIAVSRDCFPIELSRNRKNKVVEECTKKNIPIINLETIIENESDVLKALKEIKEKGVNALVIYLGNFGPEGPTSLLAQKFDGPVMVSAAAEETGKDLYGGRGDAYCGFLSLSYNLGLRNKQVYIPHYPVGIPSEIADMIKEFMPIARTILALKNLKIFSFGPRPQDFVTMHTPIKPLYDLGISIMENSELDLYDIYKQAENDPRISEVMEDMAKELGTGNTYPELLRKLAQYEVALIDFMEKNLGASQFGIFANKCWPAFEKYFGFVPCYVNSRLASRGIPVACEVDVYGALSEYIIYNVSELPATLLDVNNTVPYDLIEENKDRIRDKGYKPTDLFMGFHCGNTPSCCLINGAIKYQLIMHRLLEPGKEPDITRGTLEGRLRPGETLIFRIHATPDARLISYLAEGEILDIDPKSFGGIGVFAIKEMGRFYRYVLLEKKFPHHTAVGFKHVGKYVYEVLKLLGIKEIYYNLPENQRYPEENPFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYG0</accession>
    <name>B8DYG0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dnaA</name>
        <name evidence="13" type="ordered locus">Dtur_0001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 10">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582428.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351956.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0001"/>
    <dbReference type="EnsemblBacteria" id="ACK41342">
        <property type="protein sequence ID" value="ACK41342"/>
        <property type="gene ID" value="Dtur_0001"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0001"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_1_0"/>
    <dbReference type="InParanoid" id="B8DYG0"/>
    <dbReference type="OMA" id="REFNPLF"/>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="11">
        <location>
            <begin position="135"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_DnaA_C" evidence="12">
        <location>
            <begin position="346"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="143"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK41342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="443" mass="50664" checksum="48D1C5AAB16DABC1" modified="2009-03-03" version="1">MDDIKSIWEEALSYLSLEISRPGFETWIKTLKPLTLEGSKIVLQTPNKFSKDWLEEYYLPLIEEVIRKVTQKDFKVEILAEEKEENIPEDKKVEYLSTSYNNLNPKYTFDTFVVGDSNRFAHAAALAVSQNPGKAYNPLLIYGGVGLGKTHLIHAIGHSIQEKYPKARVVYASMEKFTVELIDAIKEDGMTKFRNRYRNIDVLLIDDIQFLAGKERTQEEFFYTFNALYEAGKQIVLTSDRVPKEIPTLEDRLRSRFEWGLIADIQPPDLETRIAILKKKAEAEKAKVPDEVIEFIASQIQSNIRELEGALIRTIAFASLNNMPINLELAKTVLKDIIQPQIKNITIQNILQAVAEYFNITVEQLKGKGRSQEIAVPRQIAMYLARTLTDLSLPKIGEELGGRDHTTVLHAYEKIQELYQTDLSIKKAIQDIQNRLRNSNSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYK7</accession>
    <name>B8DYK7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0051</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582475.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352003.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0051"/>
    <dbReference type="EnsemblBacteria" id="ACK41389">
        <property type="protein sequence ID" value="ACK41389"/>
        <property type="gene ID" value="Dtur_0051"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0051"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107136_1_1_0"/>
    <dbReference type="OMA" id="FLAYKPL"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="6"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="6">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="148" mass="17852" checksum="B514706B62FFD395" modified="2009-03-03" version="1">MREEILFLAYKPLLFKYLKMLYIPEIDFEDFKQEGEIALLEVLRRYDSQKGNLSGYVKKALYYRLLRIREKLKGKDLYLEGNNVSYEAFEEEIMIKFIDFSKLSKREKQIIILIFYSRHSEREVAKYLGISRSSVKIYKKRALNKLKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYK8</accession>
    <name>DCDB_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dCTP deaminase, dUMP-forming</fullName>
            <ecNumber evidence="1">3.5.4.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bifunctional dCTP deaminase:dUTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">DCD-DUT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dcd</name>
        <name type="ordered locus">Dtur_0052</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dCTP + 2 H2O = diphosphate + dUMP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19205"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.5.4.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dCTP deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.30" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582476.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352004.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DYK8"/>
    <dbReference type="SMR" id="B8DYK8"/>
    <dbReference type="STRING" id="515635.Dtur_0052"/>
    <dbReference type="EnsemblBacteria" id="ACK41390">
        <property type="protein sequence ID" value="ACK41390"/>
        <property type="gene ID" value="Dtur_0052"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0052"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.53"/>
    <dbReference type="eggNOG" id="COG0717">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_2_1_0"/>
    <dbReference type="InParanoid" id="B8DYK8"/>
    <dbReference type="OMA" id="PPIERIN"/>
    <dbReference type="OrthoDB" id="1598407at2"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00667"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033973">
        <property type="term" value="F:dCTP deaminase (dUMP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015949">
        <property type="term" value="P:nucleobase-containing small molecule interconversion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000189827" description="dCTP deaminase, dUMP-forming">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for bifunctional activity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <sequence length="194" mass="21824" checksum="9B7774AC81B38591" modified="2009-03-03" version="1">MILSDKDIKKYLEERKLVIHPIDDPQKQIQPSSVDLRLGNSFLHFKVEGRAYIDPTKDNPQDLMEIIEIEEGKPFFLRPGEFVLGTTIETVKLPDDLVARVDGRSSLGRLGIIVHATAGYVDPGFCGQITLELSNINRVPVALYPGMRICQISFYKLTSPAETPYYKKAGSKYHNQKGPTASKLNIDFCVKEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYL5</accession>
    <name>B8DYL5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582483.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352011.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0059"/>
    <dbReference type="EnsemblBacteria" id="ACK41397">
        <property type="protein sequence ID" value="ACK41397"/>
        <property type="gene ID" value="Dtur_0059"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0059"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.60"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_15_12_0"/>
    <dbReference type="InParanoid" id="B8DYL5"/>
    <dbReference type="OMA" id="FEEIWIN"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="194" mass="22689" checksum="EAD4515E1754A5BF" modified="2009-03-03" version="1">MKLDTKSKLILSGEKLFSQKGYDATSISDICERAGVSKGAFFHYFPTKEAFFLEILDRWLFDLSVKIDGYLEDEDRVSSGIIRMSEIFREIFKESKEKFFLFLEFLRQGIKDKEILEKLREYFKKYKSYFSFLIEKGKKEGSLKDVDSNIISCILISFSIGTILQQIFAEEEDWEKIAREGIRIIISEIEKGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYL6</accession>
    <name>B8DYL6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582484.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352012.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0060"/>
    <dbReference type="EnsemblBacteria" id="ACK41398">
        <property type="protein sequence ID" value="ACK41398"/>
        <property type="gene ID" value="Dtur_0060"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0060"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.61"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_4_1_0"/>
    <dbReference type="OMA" id="KLIVMSF"/>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="81" mass="9167" checksum="DE2C5B4D61E3500A" modified="2009-03-03" version="1">MNRKIYGMATLSERGQIVIPQEAREDLDLKPGDKLIVMCVGPKNALMLVKSDSLLELFSELTKELSELEKFISNIKEAEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYN0</accession>
    <name>B8DYN0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypA</name>
        <name evidence="5" type="ordered locus">Dtur_0074</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HypA/HybF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582498.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352026.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0074"/>
    <dbReference type="EnsemblBacteria" id="ACK41412">
        <property type="protein sequence ID" value="ACK41412"/>
        <property type="gene ID" value="Dtur_0074"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0074"/>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_2_0_0"/>
    <dbReference type="InParanoid" id="B8DYN0"/>
    <dbReference type="OMA" id="EDIHFIP"/>
    <dbReference type="OrthoDB" id="1995603at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 4" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="132" mass="15209" checksum="C81716E631499B50" modified="2009-03-03" version="1">MHEWALAEAVVKSAIDMAQKKNLSQIKLLFLRVGEVQQIDMEVFNYAIKELSKGTILENSEIKYEIFPAKLVCNNCGNIWSYMESFQGLTDEEKEAIHFIPETIHVYMKCPKCKSADFEIKEGRGVFIEDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYR3</accession>
    <name>B8DYR3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582531.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352059.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0111"/>
    <dbReference type="EnsemblBacteria" id="ACK41445">
        <property type="protein sequence ID" value="ACK41445"/>
        <property type="gene ID" value="Dtur_0111"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0111"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.115"/>
    <dbReference type="eggNOG" id="COG3459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_277846_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYR3"/>
    <dbReference type="OMA" id="PGWLENE"/>
    <dbReference type="OrthoDB" id="36122at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1088" mass="128255" checksum="F93AB8C6F80563B8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYY9</accession>
    <name>B8DYY9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582700.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352229.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0293"/>
    <dbReference type="EnsemblBacteria" id="ACK41615">
        <property type="protein sequence ID" value="ACK41615"/>
        <property type="gene ID" value="Dtur_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0293"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_2_0"/>
    <dbReference type="InParanoid" id="B8DYY9"/>
    <dbReference type="OMA" id="WEMILHA"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
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        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="103"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="640" mass="73456" checksum="4C5A0F5DE3A5E5FE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYZ8</accession>
    <name>B8DYZ8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582709.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352238.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0302"/>
    <dbReference type="EnsemblBacteria" id="ACK41624">
        <property type="protein sequence ID" value="ACK41624"/>
        <property type="gene ID" value="Dtur_0302"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0302"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_5_0_0"/>
    <dbReference type="InParanoid" id="B8DYZ8"/>
    <dbReference type="OMA" id="HRTICNI"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="178"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="393" mass="44456" checksum="C1CBCFC104A6574F" modified="2009-03-03" version="1">MDKVRVGLVGAGFIARIHMSAYKEISPYVDIVGVCSGRRENAERFAKEYGIPKVFDNYEELCASFDVDVVDVCTPTNLHDEVIICAAKNKKHVMCEKPLTGYFGEDTDKELVGIEVPKSFMYKKVLEKIEKIEKVIKENRVKFMYGENLVYAPSIEKMKRMILASSSPILEIRAECSHSGSHASYAKKWRTSGGGSLMRLGSHPVAVVLHLKHYEGLIKDGKPIRAKAVWGEVGNLTKIDKFLKEEKHYVATSWEDVEDWSVIVIDFEDGTKGIIFSNDISLGGLKNWVQVSLSSGMIYANINPNNMMVAYTPEESIWKEEYIAEKIETKAGWNFPSPDDFWTRGFPQELKDFILAVIEDREPISSFDLAKETAKVLYAGYYSSEEGRKIEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ08</accession>
    <name>B8DZ08_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0312</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582719.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352248.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0312"/>
    <dbReference type="EnsemblBacteria" id="ACK41634">
        <property type="protein sequence ID" value="ACK41634"/>
        <property type="gene ID" value="Dtur_0312"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0312"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.329"/>
    <dbReference type="eggNOG" id="COG4209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZ08"/>
    <dbReference type="OMA" id="IWREAGW"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="304" mass="35035" checksum="2866CCA8AF761AAB" modified="2009-03-03" version="1">MNFVKTLKTIKKQKYLIIMVLPFVIWLIIFRYVPLWGWITAFQNYKPGLPIFQQQWVGLKYFKEMFSDPEFYLVMRNTLAMSILSLIFGFPLPIILAILINEIRCTAFKRTVQTISYLPHFVSWVIVASIVHAMLAPDGVVNYLLLRLGLIKQPILFFGEPKYFWWIVVFSDIWKEVGWNTIIFLAAMTSINPELYEAAEVDGASRFRKIWHITLPGIMPTVIMILILSIGNIINIGFERQFLLRTSAVRNVSDVIDLYALDYGIRAGRFSFGTAAGIFKSVISLILLFSANKITKKVTGYRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ15</accession>
    <name>B8DZ15_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582726.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352255.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0321"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41641">
        <property type="protein sequence ID" value="ACK41641"/>
        <property type="gene ID" value="Dtur_0321"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0321"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_3_0"/>
    <dbReference type="InParanoid" id="B8DZ15"/>
    <dbReference type="OMA" id="FFANNNE"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102483">
        <property type="term" value="F:scopolin beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="PTHR42721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fn3_like" evidence="3">
        <location>
            <begin position="719"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="927" mass="107300" checksum="92089E0C03405B94" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ36</accession>
    <name>B8DZ36_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582747.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352276.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0350"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41662">
        <property type="protein sequence ID" value="ACK41662"/>
        <property type="gene ID" value="Dtur_0350"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0350"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061541_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ36"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="48"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="170"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="352" mass="41066" checksum="B7E493C5E7220EC7" modified="2009-03-03" version="1">MIKVAFLSDFPFSIAFGGKEVQLLSYMEHINNGNFDIKVNLLDFFKIEETFDIIHLFGYSNWFYDIVKNLKNNFPNIKIFVSPTFYYEKETRMLIGSLLSKLCPVPNFFSYKKYFLSKSDLIIVNSNAEKVQLIKLFQIDAPKIEIIYNYVDSSFAIFNNPEDANIFLRKYNLDKDEYFLSVAFLDERKNTLNLLRAFLEVYPILKKKLVLIGKFRFRNNNIKEEVEKLVYTNKDKILHIEYIDRKSDLLKSAYLNCKAHLLPSFLETPGLSNLEAGIFKKPILVGKCKPVIEYFGDKVVYCDPNSIESIKKGILKVNAQSQNIELYDLIRSKYLEKHSVDKLVNLYLSQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ55</accession>
    <name>B8DZ55_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582766.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352295.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0377"/>
    <dbReference type="EnsemblBacteria" id="ACK41681">
        <property type="protein sequence ID" value="ACK41681"/>
        <property type="gene ID" value="Dtur_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0377"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.397"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="InParanoid" id="B8DZ55"/>
    <dbReference type="OMA" id="THILVTY"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="70"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="294" mass="33980" checksum="E71A95D5E4B435DB" modified="2009-03-03" version="1">MIKKSYRFIENLIGYIFLSPWLFGLIFFGLGPLIFSIILCFSEWDLISAPKLIGFNNFLSLLEDELFWKSLRNTLLFSFSVPISTFISLFFAYLMNRPKSIFSVLRSIYFIPSVTPAVANTVVWVWLLHPQVGIINYLLKKFFSIQGPNWLGDPNWIIPSLIIIAVWGAIGYNIVLFTAGLQAIDPQIYEAAEIDGANKWQIFFKITIPLISPTTFFVLVTSFIWSFQVFDISYIATNGRPDEHSLTIVYYLFQNAFQYFKIGKASAIAWILTLIIGFVTYIEFKIEKKYVFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ68</accession>
    <name>B8DZ68_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582779.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352308.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0390"/>
    <dbReference type="EnsemblBacteria" id="ACK41694">
        <property type="protein sequence ID" value="ACK41694"/>
        <property type="gene ID" value="Dtur_0390"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0390"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.410"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="InParanoid" id="B8DZ68"/>
    <dbReference type="OMA" id="YSLFPWR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="232" mass="26147" checksum="F5EE9602D75A17D4" modified="2009-03-03" version="1">MFIEIKDLSKSYQVGLTKIDALKKLSIDFEKGKMYVILGPSGSGKTTLLNILGGIDKPDEGKVIVDGEDITNYNDRELTNYRRRKLGFIFQFYNLVNSLTVLENVLSTKYLSENGLDPKEVLEVVGMWEHRDKFPFELSGGEQQRVAIARAVVKNPSIILCDEPTGALDFENAKRVLKLLEDINKRYGTTIIIATHNTAIAKMSHKIIRLRSGELVEYQDNPSPALAEEVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ91</accession>
    <name>B8DZ91_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dinitrogenase iron-molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582909.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352438.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0534"/>
    <dbReference type="EnsemblBacteria" id="ACK41824">
        <property type="protein sequence ID" value="ACK41824"/>
        <property type="gene ID" value="Dtur_0534"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0534"/>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_3_1_0"/>
    <dbReference type="InParanoid" id="B8DZ91"/>
    <dbReference type="OMA" id="GPHMFED"/>
    <dbReference type="OrthoDB" id="1995095at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="9"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="123" mass="13837" checksum="13AC980F9482B0AD" modified="2009-03-03" version="1">MKIAVASNDGKKISAHFGRTKGFVIFEIENGEIKSREYRLNTFTGHARGFSHDDPEHHKYTHPAIIEALKDCKVVISHGMGRRLYDDLTSAGIEVYVTDETDVDKAIELYLKGELTNVSELLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZC0</accession>
    <name>B8DZC0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582938.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352467.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0563"/>
    <dbReference type="EnsemblBacteria" id="ACK41853">
        <property type="protein sequence ID" value="ACK41853"/>
        <property type="gene ID" value="Dtur_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0563"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_4_1_0"/>
    <dbReference type="InParanoid" id="B8DZC0"/>
    <dbReference type="OMA" id="LRWHPGY"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="51"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="250" mass="29073" checksum="96C87D140EA37182" modified="2009-03-03" version="1">MRNSLLFKLIFWISFIIIWYLMGTIINSNLILPPPHKVLYKVLDLFKHKDFYSHLFITFIRSTLGLFIALFSGFLLGYIKNKFFYSTIRNIIDIFQSNPLIVWITIALFWFGFGNKTIIFTVFIVLFPNFYLVTYNAINNIPKEYLELFKIYPISRKNYLIKFLIPYLKPFILPNLANSTISSLKITAMAEFLSGESGIGFLLSYAKAFLNIEEVYAYAVILFILSKILELIFIKSGILKGDKNYGFSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZC6</accession>
    <name>B8DZC6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0569</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582944.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352473.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0569"/>
    <dbReference type="EnsemblBacteria" id="ACK41859">
        <property type="protein sequence ID" value="ACK41859"/>
        <property type="gene ID" value="Dtur_0569"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0569"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.605"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="InParanoid" id="B8DZC6"/>
    <dbReference type="OMA" id="IYYWPLA"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="35"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="350"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="383"/>
            <end position="390"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="597" mass="69031" checksum="109A9A2AEFD0E0D9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZI4</accession>
    <name>B8DZI4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.78</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 26 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583002.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352531.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0629"/>
    <dbReference type="CAZy" id="GH26">
        <property type="family name" value="Glycoside Hydrolase Family 26"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41917">
        <property type="protein sequence ID" value="ACK41917"/>
        <property type="gene ID" value="Dtur_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0629"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.666"/>
    <dbReference type="eggNOG" id="COG4124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016930_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZI4"/>
    <dbReference type="OMA" id="IWIWNAP"/>
    <dbReference type="OrthoDB" id="669354at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006080">
        <property type="term" value="P:substituted mannan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022790">
        <property type="entry name" value="GH26_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000805">
        <property type="entry name" value="Glyco_hydro_26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40079">
        <property type="entry name" value="PTHR40079"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02156">
        <property type="entry name" value="Glyco_hydro_26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00739">
        <property type="entry name" value="GLHYDRLASE26"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51764">
        <property type="entry name" value="GH26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH26" evidence="5">
        <location>
            <begin position="103"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="417" mass="49040" checksum="42258DD840AFB4D0" modified="2009-03-03" version="1">MKIIEIEFIIEKQKYYDLYLNHTPLNQFSKTHVFINNLAFGEIQFPQGETHSYIGELKLKPGKYSFKINLPQEDFKIISLEIKEKDYSTTKITNYKIRPNLSDNAKRLLEFLQKIYSKYIIAGQHTNTALGPEIAYIEYFTGKKPALRGFDLLSYTPAVRTQDMTPHALIEIEGNKGSIEKAIEWAKDLGGIITLCWHWYAPLGGKDKTFYTVNTDFNLEEALLNGTEENKTLLRDIEIIAEKLSILRDLDIPILWRPLHEADGKWFWWGAKGPENYKKLYMLLYEIFTEKYRLNNLIWIWNAPHPEWKIEKDLYDIAGIDHYAPPGNYGPMKFSYDLLLRLTDNEKLVALTENGPIPDPDLLFEYEAYFLWFMPWFGDFVFNENFNSKEHFKKVYNHEKVITLENLKNLTHLFLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZK8</accession>
    <name>B8DZK8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583026.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352555.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0656"/>
    <dbReference type="EnsemblBacteria" id="ACK41941">
        <property type="protein sequence ID" value="ACK41941"/>
        <property type="gene ID" value="Dtur_0656"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0656"/>
    <dbReference type="eggNOG" id="ENOG503355C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1641401_0_0_0"/>
    <dbReference type="OMA" id="GFLIPGC"/>
    <dbReference type="OrthoDB" id="2204208at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="153" mass="17641" checksum="84E4AB09C19D3AB8" modified="2009-03-03" version="1">MRNKSIGILLLLVGVFLLLANFNLLRGEIFLLLLSAIFLILYFRMNRNIGFLIPGCILFSIFLFNTVNNLFNINPIHSLTFIGIGFLGIYFIHYFGKRDISPGEKYWSLYPGIILIIIGILISLIQSFPDYLRYLIPIVLIIVGVFLLFRHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZL5</accession>
    <name>B8DZL5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
            <ecNumber evidence="5">5.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0663</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583033.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352562.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41948">
        <property type="protein sequence ID" value="ACK41948"/>
        <property type="gene ID" value="Dtur_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0663"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="InParanoid" id="B8DZL5"/>
    <dbReference type="OMA" id="YVLNGPA"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="338" mass="38399" checksum="F9213C13335AB78D" modified="2009-03-03" version="1">MRKVKINIRDIARLANVSVATVSRVINGSPNVSEKTRKKVLKIIQEYDYHPSAFAQKLSKARTQIVALLIPYERGFILSDAFFPPLIKGMTEVFDKKEYNIMLSMIESPYIPQKYVSLYKRGIVDGYILANVKKDDPFPEILYEENIPFVSVGRVSSKLKKYPYVDTDNVKGAFEATTYFLEKGHKRIALLKGNSNYNFIQDRYEGYILALKKYGIKPDPKLIVEDTLTIDGGYKAMKKLLKINNPPTAVLACSDYMAIGAMDAILEEKWEIPEDVAIIGFDDLYIDGKIEPPLASVRQEIEEMGKEAAKLFLHILDNPIDFEPIILPATFIWRRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZL9</accession>
    <name>B8DZL9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583037.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352566.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0667"/>
    <dbReference type="EnsemblBacteria" id="ACK41952">
        <property type="protein sequence ID" value="ACK41952"/>
        <property type="gene ID" value="Dtur_0667"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0667"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8DZL9"/>
    <dbReference type="OMA" id="PYHTIGK"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="326" mass="36503" checksum="D19E79BD9E6F1E73" modified="2009-03-03" version="1">MAELLRVNNLKTYFDRYDGVVKAVDGVSYKVDYGETLAIVGESGSGKTQSVLSLLRLIKGNGRIVDGEAIFEGKDLLKLSKEELRQIRGKDISIVFQDPMTSLNPIMRIGIQIMEPILWHKIMSDKEARERAIELLRVVGIPEYKTRVWDYPFQFSGGMRQRVMIAIALACNPKLVIADEPTTALDVTVRAQILNLLSDMKEEFKTSVIFITHDVTLAMNFADTIMVMYAGKIAEYAPIDKFIRNPLHPYSNGLISSTLDINAKEGTLKPIPGNPPSLVNPPSGCRFHPRCPYAQDICKEVEPEYREVEDGHYVACHLVKGGKFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZM0</accession>
    <name>B8DZM0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0668</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583038.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352567.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0668"/>
    <dbReference type="EnsemblBacteria" id="ACK41953">
        <property type="protein sequence ID" value="ACK41953"/>
        <property type="gene ID" value="Dtur_0668"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0668"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8DZM0"/>
    <dbReference type="OMA" id="RCHLYRP"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="315" mass="35706" checksum="893DD5E83EA7FEF3" modified="2009-03-03" version="1">MPELLVVKNLKKYFPVRRKFLKAVDNVSFSLEQGETLGLVGESGSGKSTLGRSILRLIEPDDGEIIFDGVDIRKLRGEELRQRRRFMQIIFQDPLASLNPMMTIGQNIEDPLIIHNIGTKEERRRAVEELLEIVGLGREVIDAFPHEFSGGQQQRVGIARALALNPKFIVADEPVSSLDVSIQAQIVSLLYELKRRFKISYLFISHDLAVVRYLSDKVAVMYLGAIVEMAPKEELYQNPLHPYTRALLASVPKMPRDGERQKRFPALKGEIPSPIDLPPGCRFQSRCEYVMDVCRKQEPAFREVSPGHFVACHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZM2</accession>
    <name>B8DZM2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583040.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352569.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DZM2"/>
    <dbReference type="STRING" id="515635.Dtur_0670"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41955">
        <property type="protein sequence ID" value="ACK41955"/>
        <property type="gene ID" value="Dtur_0670"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0670"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.708"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018668_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZM2"/>
    <dbReference type="OMA" id="SIEKRIF"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006073">
        <property type="term" value="P:cellular glucan metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="312" mass="37003" checksum="DC0A4833D0F9D549" modified="2009-03-03" version="1">MNNLPIKRGINFGDALEAPYEGAWSGYIIKDEYFKIVKDAGFDHVRIPIKWSVYTQKEAPYSIEKRIFDRVDHLIEEGLKNNLHVIINIHHYEEIMEDPLGEKERFLAIWRQISEHYKDYPNNLYFELLNEPTQNLSSELWNQFLKEAIEVIRRTNPERKIIVGPDNWNSLYNLEKLIIPENDENIIITFHYYNPFPFTHQGAGWVKIDLPVGVKWLGTEEEKREIERELDMAVSWAEEHGNIPLYMGEFGAYSKADMESRVRWTDFVARSAEKRGIAWSYWEFYSGFGVFDPEKNEWRTPLLRALIPERNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZP1</accession>
    <name>B8DZP1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ordered locus">Dtur_0689</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
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        <property type="protein sequence ID" value="ACK41974.1"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:sulfurtransferase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
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        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="291"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="343" mass="39280" checksum="564560A6EAFDC085" modified="2009-03-03" version="1">MSIKVAVGMSGGVDSSITAYLLKKEGYEVIGLTMNIAYSSSIKDAKKVAEYLNIPHFFVDLKNEFEEKIIKYFVESYKHGYTPNPCVFCNKLIKFGLLLEKAKELGADFLSTGHYVRKVWDEERKTYLLMRAKDLKKDQSYFLGMLTQEQIKKTLFPLGELTKEEVRKIADELGIFVANKKESQDICFLPDKDYKRFLSKYLEDKPGKIITEDGKEVGYHSGVFSFTIGQRRGLRVALGVPVYVRDIDPNTGNVTVTDREKVFGKEVYAVNVNYPSYFPEKRELRAYAMIRYNMKPSPGVLKIVSEKEVLFIFDDPQWAITPGQILVCYLDNHVLCAGIIERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZP2</accession>
    <name>B8DZP2_DICTD</name>
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        <submittedName>
            <fullName evidence="3">Anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
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            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="ACK41975"/>
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    <dbReference type="PATRIC" id="fig|515635.4.peg.728"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
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        <property type="entry name" value="SSF56322"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="198"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="465" mass="53452" checksum="D75BB95D551AFE82" modified="2009-03-03" version="1">MEKILSTKNYVPIIYDFPGDFETPSSLLFKVRDEDFLFLLESAEGGERVGRYSFISWRPKEVLTFNNDVNFDILTYLSERFPVVNVKNGKILPRFVGGLVGYFGYDLVRQWEKLPNLTHDPIGFPLAEFQVVDFLVVFDHLKRRISVIFLIPEEEIGNFEVKDRIEEKISEIKEVLKKPVGNLCKANINAQIENLTSKDEYEENVKKAIEYIKAGEIFQVVYSQRFYTRYEGDPYLLYRALRFVNPSPYMFFLKFKDRYLIGSSPEALVKVEEGKAEIRPIAGTRRRGKDEEEDISLEKELLRDEKEKAEHTMLLDLARNDLGRVAKIGTVRCENLMHVEKYSHVMHLVSTVTCDVREGIHPLEVLRASFPAGTVSGAPKVRAMEIIEELEKYRRGPYAGGVGYFSLNGNLDTCITIRTYLLKGKDLFIQTGAGIVYDSIPEREYKECINKAKALFEAIKIVGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZT8</accession>
    <name>B8DZT8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352635.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0739"/>
    <dbReference type="EnsemblBacteria" id="ACK42021">
        <property type="protein sequence ID" value="ACK42021"/>
        <property type="gene ID" value="Dtur_0739"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0739"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_4_0"/>
    <dbReference type="InParanoid" id="B8DZT8"/>
    <dbReference type="OMA" id="SVIKLDF"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039562">
        <property type="entry name" value="MFP_biotin_lipoyl_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13533">
        <property type="entry name" value="Biotin_lipoyl_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin_lipoyl_2" evidence="1">
        <location>
            <begin position="54"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="362" mass="40685" checksum="1E1CE33075D525DC" modified="2009-03-03" version="1">MKRILIVVFIIIALALTIFYKLNNTLSVKVERVNRKNLNLTINLSGNLSFLRKIEIYPKISGTVREVRVKPGDKVKKGEVLAIIDAEDLKKQIEQIKNIIELAKISSAFSTFNPQSEIKISQDQIKTLESYYESLNKLYEERIIRSPINGIIAKINISPLETVQASQNNLNLNNLLGNFANLLNMFNLSLPQNNPAFIVIDPTSLNAILKVDENNILKIKEGQKAVVNVDALDQNPWEGKVASISKIPSLNKDGTYSYEIYIPLPQLGEMVVEGMTISATINIGEKKNILTIPLNAITFKEGKTYVYLYENGRAKEKEIMIGDMTLDEIEIKEGLREGDLVIISPIDKISNNMKVKIENSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZU7</accession>
    <name>B8DZU7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAF sensor signal transduction histidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0748</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583115.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352644.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0748"/>
    <dbReference type="EnsemblBacteria" id="ACK42030">
        <property type="protein sequence ID" value="ACK42030"/>
        <property type="gene ID" value="Dtur_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0748"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018434_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZU7"/>
    <dbReference type="OMA" id="GNAIFIF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <source>
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        <source>
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        </source>
    </evidence>
    <sequence length="815" mass="92507" checksum="D6F9328B57E30F39" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZV0</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">Dtur_0751</name>
    </gene>
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACK42033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="284" mass="31391" checksum="93E6C99D06C91A8A" modified="2009-03-03" version="1">MLKNKTEKEKAYIFLIIGITAMASASLIIRLTSAPPIIIASYRLLIASLILLLLNRKTLKLPKNLPILLIAGLSLGMHFYSWISSLFLTTVANAVVLVNTSPIFISLLSYIFEKKKPTRSFFLSLFFILLGIVLITNNKISLKFGKGELLAILGAITFAIYLYTGRYLSPNLSVSSYITLVYFTGGIILLVFAILTKTPLIVYPLKIYFNVFLLALIPQLIGHTSANYAIRILSTNATSIILIGETVIATLLALVFLKEKITLLQTLGMLLIIIGIIYSSLKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E018</accession>
    <name>B8E018_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <shortName evidence="12">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
            <ecNumber evidence="4 12">3.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lpxC</name>
        <name evidence="13" type="ordered locus">Dtur_0820</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LpxC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="4 12"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583185.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352715.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0820"/>
    <dbReference type="EnsemblBacteria" id="ACK42101">
        <property type="protein sequence ID" value="ACK42101"/>
        <property type="gene ID" value="Dtur_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0820"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.859"/>
    <dbReference type="eggNOG" id="COG0774">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046528_1_0_0"/>
    <dbReference type="InParanoid" id="B8E018"/>
    <dbReference type="OMA" id="IVFYRSD"/>
    <dbReference type="OrthoDB" id="428602at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="285" mass="32247" checksum="DBA961C452907244" modified="2009-03-03" version="1">MGRDKEAEKNLRRQATIDKPFTVEGKGLHTGGISKVTFVPAPSDTGIVFIKEGVRIPALYNYVSDTKRRVILKNKDKSVSTVEHLLSAIYALGISNLFIYIEGEEIPILDGSALKWCELLESAGIKIQDTRRRTFYLKENLVVRSNNSLLLLFPSNRFEVLCVISFPKSFIKWQRFYLESLDKYFTEIAPARTFGFYYEVKDLIEKGLISGADLESALLIGEEWYVNSPRFWDEPVRHKILDIIGDFSLLGIDLKMKIISIGSGHSLHVKALEILTDKIEGGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E041</accession>
    <name>B8E041_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase, sigma-24 subunit, ECF subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583208.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352738.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0843"/>
    <dbReference type="EnsemblBacteria" id="ACK42124">
        <property type="protein sequence ID" value="ACK42124"/>
        <property type="gene ID" value="Dtur_0843"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0843"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.882"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_0_0"/>
    <dbReference type="InParanoid" id="B8E041"/>
    <dbReference type="OMA" id="LVDMQGY"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="53"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="159"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="223" mass="26245" checksum="656C92A32A56D4A3" modified="2009-03-03" version="1">MEKSIINVIKGKYPLSTHTSQPSPLGWEEKNKLSDQSLISLIKNGDKEAFNILVKRYEKKVLNILYLQLGNIPDLEDLAQEVFIKIFKNIKGFRGEAKFSTWIYRITMNVAYDYKRKNKEMYSLDEPMKEDEEDTFEKVIPSEEEDPLSVVEREDIRSKLQKLIRELPKEYQEVLILREYEGLSYEEISNILKCPVGTVESRLFRARRELKEKLLREVGSYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>B8E060</accession>
    <name>B8E060_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352757.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0862"/>
    <dbReference type="EnsemblBacteria" id="ACK42143">
        <property type="protein sequence ID" value="ACK42143"/>
        <property type="gene ID" value="Dtur_0862"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0862"/>
    <dbReference type="HOGENOM" id="CLU_3355846_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="36" mass="3918" checksum="0210F0F3C1117756" modified="2009-03-03" version="1">MKGGGEGNSKLASLTGLNWEFREEALYPFWGKGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E063</accession>
    <name>B8E063_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583230.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352760.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0865"/>
    <dbReference type="EnsemblBacteria" id="ACK42146">
        <property type="protein sequence ID" value="ACK42146"/>
        <property type="gene ID" value="Dtur_0865"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0865"/>
    <dbReference type="eggNOG" id="COG1167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_0"/>
    <dbReference type="InParanoid" id="B8E063"/>
    <dbReference type="OMA" id="MRLNFTY"/>
    <dbReference type="OrthoDB" id="1024978at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="43"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="404" mass="46473" checksum="567BCE4274892150" modified="2009-03-03" version="1">MGYRKFSKRISQRTSDAMSKFVLAQDPETISFAGGLPDNNLFPVEELKYAYEEVLRTEGNCAFQYSSTMGDLKLRELIGEQFFSKWGLTINPENIILTEGSQQALDLLGKLFLDEDDIALIEEPGYLGTIQAWSMFTSRLIGIPQDEYGINTDYLEDVLRNLDERVKVLYIVPDFSNPAGTCLVIERRKKILELSEKYDFFVVEDLAYSLLSYDTNTLPPLITISKSEKIITIGSFSKILSPGLRTGFIIANREVINALIRLKEASDLCSGTLNQKMIYQYWRLGFLEKHVEKLRKSYKEKRDALKTALENTFKTIAKWNYPQGGFFFFLTFPEWVDAYKLAEYALNNKTSFVPGEEFFVSQEGKNTARISFSQVPVDKVEEGVKRLIRAWEEYKEKEKEKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E068</accession>
    <name>B8E068_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0473 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583235.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352765.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0870"/>
    <dbReference type="EnsemblBacteria" id="ACK42151">
        <property type="protein sequence ID" value="ACK42151"/>
        <property type="gene ID" value="Dtur_0870"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0870"/>
    <dbReference type="HOGENOM" id="CLU_2287000_0_0_0"/>
    <dbReference type="OMA" id="EVYIFRC"/>
    <dbReference type="OrthoDB" id="2057244at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009711">
        <property type="entry name" value="UPF0473"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06949">
        <property type="entry name" value="DUF1292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="111" mass="13566" checksum="51DBFCCBDCAAD96F" modified="2009-03-03" version="1">MPDKDYEEDIIVLEGEDGNTYEYVVRDFVEVDDKTYVLLTPKDSEDMEEVYIFRCRLAEKDGELYIEALEEIEDDDEYERVIEALEEEEEWEDEDWEEDELEEEEDWEEDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E071</accession>
    <name>B8E071_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein-secreting ATPase</fullName>
            <ecNumber evidence="3">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583238.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352768.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0873"/>
    <dbReference type="EnsemblBacteria" id="ACK42154">
        <property type="protein sequence ID" value="ACK42154"/>
        <property type="gene ID" value="Dtur_0873"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0873"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.911"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_8_0_0"/>
    <dbReference type="InParanoid" id="B8E071"/>
    <dbReference type="OMA" id="NMGVPAF"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013369">
        <property type="entry name" value="T2SS_GspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02533">
        <property type="entry name" value="type_II_gspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T2SP_E" evidence="5">
        <location>
            <begin position="686"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="450"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="871" mass="97802" checksum="42B5BE1C008F6347" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E095</accession>
    <name>B8E095_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine diphosphokinase</fullName>
            <ecNumber evidence="1">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.6.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583622.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353154.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1262"/>
    <dbReference type="EnsemblBacteria" id="ACK42540">
        <property type="protein sequence ID" value="ACK42540"/>
        <property type="gene ID" value="Dtur_1262"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1262"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1302"/>
    <dbReference type="eggNOG" id="COG1564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044237_1_1_0"/>
    <dbReference type="InParanoid" id="B8E095"/>
    <dbReference type="OMA" id="ITYCPEG"/>
    <dbReference type="OrthoDB" id="1628990at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="SSF63862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPK_B1_binding" evidence="6">
        <location>
            <begin position="153"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="219" mass="25072" checksum="F9BE4018EFB483D4" modified="2009-03-03" version="1">MNKEVKKILIFVNGETKITTFDLDEILPVDKVICANGGTKIALRLGIFPNIIVGDLDSITEDIEKRLAKHQVEWKIYPTEKDETDLELAIREAVKFNPNSIYIVGLLGGRIDHTLANIFFLERIKDLNIEPHVIDRKLRIYIMKGEEEKTIWGNKGDILSLIPLSEIVEGIYLEGLKYSLNYEPLYRNLTRGISNVFTDYQAKISIQKGTLLVIHLYQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E099</accession>
    <name>B8E099_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, BadM/Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583626.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353158.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1266"/>
    <dbReference type="EnsemblBacteria" id="ACK42544">
        <property type="protein sequence ID" value="ACK42544"/>
        <property type="gene ID" value="Dtur_1266"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1266"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_0_1_0"/>
    <dbReference type="InParanoid" id="B8E099"/>
    <dbReference type="OMA" id="YGLTIMM"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="138" mass="16051" checksum="98E28B69E74DCA6E" modified="2009-03-03" version="1">MKLPTRSRYGLRALIYIAKNQKEENPVSVRKIAEAEEIPLRYLERIMRILSQKGYVRAEVGAEGGYYLSMLPENIKILDVVEALEGRINLVDCLHGIKCKRMAYCPTRPLWMEMTKSLKETLAKYTLADFLREEEKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0D4</accession>
    <name>B8E0D4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-alkenal reductase</fullName>
            <ecNumber evidence="6">1.3.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.74" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583661.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353193.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1305"/>
    <dbReference type="EnsemblBacteria" id="ACK42579">
        <property type="protein sequence ID" value="ACK42579"/>
        <property type="gene ID" value="Dtur_1305"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1305"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_0"/>
    <dbReference type="InParanoid" id="B8E0D4"/>
    <dbReference type="OMA" id="IIGINRQ"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="280"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="389" mass="41765" checksum="C3BAAB6CF6D23F10" modified="2009-03-03" version="1">MRRERGVWQVLLIIFILGALIGGFIGSVGGYYLLNKNSPASSETKINNVVPTQEVYIPSSLGAFEKDIVAVVKKSMPAVVNISTITLVEDFFFGIYPSSGVGSGFIIDPKGYILTNYHVVEGARKIDVTLSEGKKYSGRVVGYDKRSDLAVIKIDAENLPALPLGDSDKLEPGQFAIAIGNPYGLNRTVTLGIVSALNRTIVEPNGVRLENLIQTDAAINPGNSGGPLINIKGEVIGINTAIKSDAQGIGFAIPINKAKQIADKLIKEGKITYPWLGIRGYAITSDMLDYIKFPVDKGVVIAEVVPGSPADKAGLKGGDRIIYVDSTQIIVGGDIITKIDGKPVESMEELRSEIQKRKVGDTVVITYIRSGKEYTVKIQLEAMPDNLSG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0D5</accession>
    <name>RLMH_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name type="ordered locus">Dtur_1306</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583662.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353194.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0D5"/>
    <dbReference type="SMR" id="B8E0D5"/>
    <dbReference type="STRING" id="515635.Dtur_1306"/>
    <dbReference type="EnsemblBacteria" id="ACK42580">
        <property type="protein sequence ID" value="ACK42580"/>
        <property type="gene ID" value="Dtur_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1306"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1350"/>
    <dbReference type="eggNOG" id="COG1576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100552_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0D5"/>
    <dbReference type="OMA" id="NEPYHHQ"/>
    <dbReference type="OrthoDB" id="1783583at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000131228" description="Ribosomal RNA large subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <sequence length="152" mass="17761" checksum="F80C2C49065AF06D" modified="2009-03-03" version="1">MQFKILVVGKLRNEFIKAGVNEYLKRLLPFINIKIEFLPSFSELPEKMALLKEEEIILKNIKNNEFIIILDKNGEKLSSEEFSNKLFKLTTLNPQITFVIGGIYGVSENIKKSSKFLLSLSPMTFTHEFALLILLEQIYRAFKINRNEPYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0G8</accession>
    <name>B8E0G8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583694.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353227.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1339"/>
    <dbReference type="EnsemblBacteria" id="ACK42613">
        <property type="protein sequence ID" value="ACK42613"/>
        <property type="gene ID" value="Dtur_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1339"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911225_0_0_0"/>
    <dbReference type="OMA" id="MFPGLEL"/>
    <dbReference type="OrthoDB" id="617504at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="307" mass="35734" checksum="90831403C004B1B8" modified="2009-03-03" version="1">MIHPKVLLREAIYYAPRGEARLQLLGSIIAQNFLSHEDKLIGLIGDSGSGKSLLIRGMFPGLNLTNDDEGVYRRPLPLIEDYERGRFYEYIYHLDVRFELAFYPIYLIAEAILKALEEDRKIVCEHFELIYSYIKRNADLLIGVGEEVIVARPNIFGPLPEEIVAIVFPSLSYRLQAHTAEDLTGMILEDHGYLRYIEGHSDVKHGFVIRLKEKLQVDISDLEREVKNYIEKGVEVSYLDRQHIKIGERIIPCTGPRLHVKNTRDIKEFYLYPDFIFDKEEEDYLLVGFVDKLEYDKIVNKLKERGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0H0</accession>
    <name>B8E0H0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit</fullName>
            <ecNumber evidence="8">4.2.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583696.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353229.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1341"/>
    <dbReference type="EnsemblBacteria" id="ACK42615">
        <property type="protein sequence ID" value="ACK42615"/>
        <property type="gene ID" value="Dtur_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1341"/>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041245_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0H0"/>
    <dbReference type="OMA" id="IETYPTH"/>
    <dbReference type="OrthoDB" id="972093at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="280" mass="31017" checksum="904513784836BA55" modified="2009-03-03" version="1">MFRVINQEEIYKKLVDLIEKVNFSLPEDVEKALLESRKKEEDKNAQIVLDILIENAKIAKEKKIPVCQDCGMVVAFVEIGRNLCINGNIENAINDAVRTVYVNDFLRKSVVRDPLRRINTEDNTPAVIHYDVVDGDKLRINILIKGFGSENASVVKNLLPTVSREELINEIIEHIKLFGPNACPPLIVGIGIGGTLEKAAILSKKALLRPIGKHNDDPFWASLEDELLEKINNLNIGPGGLGGKTTALAVNIESYPVHIAGFTLAINLQCCAVRHGWVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0J8</accession>
    <name>B8E0J8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="ordered locus">Dtur_1369</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583723.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353257.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1369"/>
    <dbReference type="EnsemblBacteria" id="ACK42643">
        <property type="protein sequence ID" value="ACK42643"/>
        <property type="gene ID" value="Dtur_1369"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1369"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1414"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0J8"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="39"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="158"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="332" mass="37389" checksum="587C6E2E371481EF" modified="2009-03-03" version="1">MGYKIAVVGATGLVGQEMLKILYERKIPISELYAFASAKSEGTYVEFGNEKIKVEKATADGIAKAEFALFSIGEEISLELAPEIAKKGTIIIDNSNAFRMDPEVPLVIPEINPEDLKNHKNIIANPNCSTIQMLVALNPLHKRWKLKRIFVATYQSVSGKGKDAIDELLTSTSAFLKREDHPPKVFPHPIAFNLIPHIDSFEDENYTREEMKMVRETHKILHDPTIKVSPTCVRTPVIRGHSEVINAEFQDDFSLEEVFEVLSNAPGVRVLDEPSNKVYPMPIFCEGRDEVFVGRIRKDLFNPRSINMWVVSDNIRKGAALNAIQILEYLIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0M0</accession>
    <name>NIKR_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_1768</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="1">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584115.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353654.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0M0"/>
    <dbReference type="SMR" id="B8E0M0"/>
    <dbReference type="STRING" id="515635.Dtur_1768"/>
    <dbReference type="EnsemblBacteria" id="ACK43040">
        <property type="protein sequence ID" value="ACK43040"/>
        <property type="gene ID" value="Dtur_1768"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1768"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1820"/>
    <dbReference type="eggNOG" id="COG0864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_1_2_0"/>
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        <property type="entry name" value="CopG"/>
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        <property type="entry name" value="Ni_resp_reg_NikR"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RHH_1"/>
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    </dbReference>
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        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000125815" description="Putative nickel-responsive regulator">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
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        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <sequence length="135" mass="15890" checksum="474B1196A2A4557C" modified="2009-03-03" version="1">MAKIVRFGVSIEEDLLENFDKIIEDKGYNSRSEAIRDLIRDYIIKEKWNLKKEKVAGSISLIYEHDVYGLSEKLTDIQHHYHDVIISTLHVHLDEKNCMEVILVRGKVEKIKRLYDELSSLKWVRHTNIAITDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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            <taxon>Dictyoglomaceae</taxon>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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    <dbReference type="RefSeq" id="YP_002353655.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1769"/>
    <dbReference type="EnsemblBacteria" id="ACK43041">
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    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1769"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1821"/>
    <dbReference type="eggNOG" id="COG1606">
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    <dbReference type="HOGENOM" id="CLU_061181_2_0_0"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="LarE"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="14"/>
            <end position="75"/>
        </location>
    </feature>
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        <location>
            <position position="174"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="268" mass="31229" checksum="1DE2BA5A252DEC02" modified="2009-03-03" version="1">MKEKLEELKNFLRDCKKVVVAYSGGVDSTFLLKVAKDTLGDNVLAVTLISPIFPEREIKEAKRIAEELGVRHIILKNDELLKHEEFIKNPPERCYICKKYNFQKIIEVAKENNIDCVLDGSNVDDLKDYRPGKMALKELGILSPLLELGFSKEEIRRLSREFNLPTSEKPSLACLATRIPYGERIEIERLKRIEEGEDYLTKLGFNQVRVRDYKNMARIEIEEENFSLILKKDIREKIIRKLKELGYKYITLDLEGYRTGSMNQEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
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        <name evidence="5" type="ordered locus">Dtur_1772</name>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1772"/>
    <dbReference type="EnsemblBacteria" id="ACK43044">
        <property type="protein sequence ID" value="ACK43044"/>
        <property type="gene ID" value="Dtur_1772"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1772"/>
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    <dbReference type="eggNOG" id="COG1593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="903568at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010656">
        <property type="entry name" value="DctM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004681">
        <property type="entry name" value="TRAP_DctM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33362">
        <property type="entry name" value="PTHR33362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06808">
        <property type="entry name" value="DctM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HI0050"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00786">
        <property type="entry name" value="dctM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="DctM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK43044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="427" mass="46301" checksum="93BB006C9A342417" modified="2009-03-03" version="1">MLLVIIFFFLFMLLGMPVVFAIAISGFLFFLQHPEIPITTPIQLPLTQNINFALLAIPLFITAGNMMNYTGITKRLIDLSMVLVGHLRGGLAHVTCVLSALMGGVSGSAIADAAMEARMLGPEMIKRGLPKGYAAGALVYSSLEVPTIPPSIGLVLFGTIAQVSIGRLFAGGIIPGLLVMTFLMITVAITSRIRNFAPLREKRASILEIGISFIKSIWAIIFPVILIVGLRGGLFTPSEIGALCVVYALFVGILAYRELTLKNFIEALRDSTIDIGATMSLIAFSNIFSYGIVWERIPEIISSWILGITTNPYIFYLILIALLLVAGCFIDATVLILMLTSIFFPIAIKLGIDPVHFGLVFVMTCAIGNFTPPVGAAMYAVCTILDVSLEEFLKESWPFLLAVVLAIVTLIFFPSLVLFIPNLIFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0N1</accession>
    <name>B8E0N1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
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            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584125.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353665.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1779"/>
    <dbReference type="EnsemblBacteria" id="ACK43051">
        <property type="protein sequence ID" value="ACK43051"/>
        <property type="gene ID" value="Dtur_1779"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1779"/>
    <dbReference type="HOGENOM" id="CLU_2478375_0_0_0"/>
    <dbReference type="OMA" id="FYYTALE"/>
    <dbReference type="OrthoDB" id="2147069at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK43051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="87" mass="10454" checksum="1D33CDCABE9BCA43" modified="2009-03-03" version="1">MKKGFKSTFDWEEKLIAFYYTALENYVEKLELSDRLKDEFDEEVDSDDLMILAQFLALATKKFLQQEGWLKQEDDFDLFFPPSPYIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0N2</accession>
    <name>B8E0N2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584126.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353666.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1780"/>
    <dbReference type="EnsemblBacteria" id="ACK43052">
        <property type="protein sequence ID" value="ACK43052"/>
        <property type="gene ID" value="Dtur_1780"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1780"/>
    <dbReference type="eggNOG" id="COG1693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073525_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0N2"/>
    <dbReference type="OMA" id="IFIASRM"/>
    <dbReference type="OrthoDB" id="489307at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002846">
        <property type="entry name" value="NRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038982">
        <property type="entry name" value="NrpR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036984">
        <property type="entry name" value="NrpR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013668">
        <property type="entry name" value="RNase_R_HTH_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41964">
        <property type="entry name" value="PTHR41964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08461">
        <property type="entry name" value="HTH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01995">
        <property type="entry name" value="NRD1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_12" evidence="2">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="NRD1_2" evidence="1">
        <location>
            <begin position="84"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="330" mass="36644" checksum="3E98C61A665ADED2" modified="2009-03-03" version="1">MNKDIERKVIAILEILNNYNEPVGANTISEKLLEKGIELSDRAVRYHLKIMDERGLTKVVGKKGRLITEKGREEIKKALIADKLGFIISKIENLAYQVTLDRSTGKGKVILNLSIIPKKDLQKSLNIMKDILKKGYGISEKIIIFDKKEEEIIPGVIVPEKSVILGTVCSVTIHGVLIKNGIPVNAKFAGVLEVKDHEPTRFLEAITYNGSTLDPLEIFIKSKMTSISSVVKKKEGRVLATFREIPNSAREDAQNIIEELKEIDIKGKIYLGKPNQELFGVPVTQGTSALVIVGGLNPIAGIIEADIEAENKAMSILYNYEDLKPIKDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0R3</accession>
    <name>B8E0R3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rqc2 homolog RqcH</fullName>
            <shortName evidence="1">RqcH</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rqcH</name>
        <name evidence="3" type="ordered locus">Dtur_1812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with stalled 50S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NEMF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584157.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353697.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1812"/>
    <dbReference type="EnsemblBacteria" id="ACK43083">
        <property type="protein sequence ID" value="ACK43083"/>
        <property type="gene ID" value="Dtur_1812"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1812"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1864"/>
    <dbReference type="eggNOG" id="COG1293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022481_2_1_0"/>
    <dbReference type="InParanoid" id="B8E0R3"/>
    <dbReference type="OMA" id="SKPGFVI"/>
    <dbReference type="OrthoDB" id="713667at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00844_B">
        <property type="entry name" value="RqcH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043682">
        <property type="entry name" value="RqcH_bacterial"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="448"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="568" mass="67127" checksum="41C4E5E2ABE68C70" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0S4</accession>
    <name>B8E0S4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583739.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353275.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1387"/>
    <dbReference type="EnsemblBacteria" id="ACK42661">
        <property type="protein sequence ID" value="ACK42661"/>
        <property type="gene ID" value="Dtur_1387"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1387"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1434"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_1_2_0"/>
    <dbReference type="InParanoid" id="B8E0S4"/>
    <dbReference type="OMA" id="YNPGHVM"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="171" mass="20082" checksum="144542F05F0B464E" modified="2009-03-03" version="1">MKRLFCPWRIKYVVSEKEKDCIFCKKLLENKDEENLILLRGRFNFIILNLYPYNNGHLMIVPYEHTNDITKLDTETLMEMMRFLQLSVKALKETMNPHGFNIGFNIGEVAGAGIAEHLHMHVVPRWNGDTNFMFVLGETKVIPEDLQSTYKKLKPVLDRLYEEEKKSQESS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0X3</accession>
    <name>RLMN_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="1">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmN</name>
        <name type="ordered locus">Dtur_1436</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583788.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353324.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0X3"/>
    <dbReference type="SMR" id="B8E0X3"/>
    <dbReference type="STRING" id="515635.Dtur_1436"/>
    <dbReference type="EnsemblBacteria" id="ACK42710">
        <property type="protein sequence ID" value="ACK42710"/>
        <property type="gene ID" value="Dtur_1436"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1436"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1483"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0X3"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000188567" description="Probable dual-specificity RNA methyltransferase RlmN">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="95"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="1">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="(transient)" evidence="1">
        <location>
            <begin position="102"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="348" mass="40083" checksum="1DC5D0E6EAC305CA" modified="2009-03-03" version="1">MNNILSFEINEIRNILQGWGEPSYRADQIFDWIYKKLVLNPLDMTNLSKTLRQKLLEYFSFQIPKVVRITGDGNTKKYLLELEDGENIETVLISHKNRNTVCVSVQVGCPIGCKFCATGLIGLKRNLETHEIIGQLMVIQEDLEKKEEKISNVVYMGMGEPLANYDNVIKSIRIIKEEWGFNIGSKHITLSTIGIIPKIYQLAEENLKIRLAISLHASNNELRSKIIPINKEYPIEELLESAFYYAEKTGRRVTFEYVLIKNFNDRREDAKELVRLLKGKPAHVNLIPWNKVREYPWETSDLKDIFRFKEILANSGINVTLRISYGSKIKAGCGQLRALYLKNKGETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E106</accession>
    <name>B8E106_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ordered locus">Dtur_1469</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583821.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353357.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1469"/>
    <dbReference type="EnsemblBacteria" id="ACK42743">
        <property type="protein sequence ID" value="ACK42743"/>
        <property type="gene ID" value="Dtur_1469"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1469"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1518"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_0_0_0"/>
    <dbReference type="InParanoid" id="B8E106"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="195"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="38334" checksum="4688C31FAA81D5AB" modified="2009-03-03" version="1">MKIGRILSGMRPTGKLHLGHLLGVLKNWVELQDSYECFFEIADWHALTTHYRETEEVVENVLNMICDWLAVGIDPKKSVIFRQSDIIEHAELFLLFSMIVPLPWLERNPTYKEQLREMEGRDLMTYGFLGYPVLQAADILIYRADTVPVGEDQLPHLELTREIARRFNYFYSPIFPEPQAKLSEVPELVGIDGRKMSKSYGNTIPLDTEEEELKKLVRSMITDPARIRKNDPGHPEVCTVFAYHKIFNKEEIEEIDYACRNAQIGCVECKMKLAEKLNQFLAPIREKRKIYSKDRDLTWSILLEGNKKAREEAQKTMELVREAMRIKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8E116</accession>
    <name>B8E116_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">radA</name>
        <name evidence="9" type="ordered locus">Dtur_1479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583831.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353367.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1479"/>
    <dbReference type="MEROPS" id="S16.A04"/>
    <dbReference type="EnsemblBacteria" id="ACK42753">
        <property type="protein sequence ID" value="ACK42753"/>
        <property type="gene ID" value="Dtur_1479"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1479"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1528"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_0"/>
    <dbReference type="InParanoid" id="B8E116"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="OrthoDB" id="505485at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SF4 helicase" evidence="8">
        <location>
            <begin position="61"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="64"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="350"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="457" mass="51099" checksum="1808B47687268A27" modified="2009-03-03" version="1">MSKVKSKFVCQVCGYESVRWFGRCPNCQSWNSFIEITEKKQGFNNRESKENLGVYRLEDILNYEPVRLKTGLTGFDYVIGGGIVEGEVILLAGEPGIGKSTLLLQLAISLDKNDTRVLYISAEESLSQVGLRLRRLNSGDKLNIDFVSERDIENILPNLENSNYSLIIVDSIQTIYSSEFPTSPGNVVQVRECTSKLVDFAKKNNIAVILVGHVTKEGDIAGPKILEHLVDAVLYLEGERYHDLRILRVIKNRFGPTNDFILYEMKENGLFEVEDISAKVIENRNTNVSGSIIIPIMEGTKPLLIELQTLVSRTNTSYPRRITSGIDLNKLVLILAILEKKLNISFSDKDVFVNVVGGIKISEPAIDLGLAFALLSALINKPFPSDMVAIGEIGLGGEVRTVPHIERRLKEAKKFGFNKALIPKDSKVKSYEYNMNVRTITDIGEGIDLVWGEKWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E133</accession>
    <name>B8E133_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ThiI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583848.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353384.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1496"/>
    <dbReference type="EnsemblBacteria" id="ACK42770">
        <property type="protein sequence ID" value="ACK42770"/>
        <property type="gene ID" value="Dtur_1496"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1496"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1545"/>
    <dbReference type="eggNOG" id="COG0301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053822_0_0_0"/>
    <dbReference type="InParanoid" id="B8E133"/>
    <dbReference type="OMA" id="CIDCHAN"/>
    <dbReference type="OrthoDB" id="1230735at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiI" evidence="3">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="327" mass="37630" checksum="15E0F82F3381C4B9" modified="2009-03-03" version="1">MKKARAISLISGGLDSILATWLILQQNIDVIGITFSTPFFNLERAKRACEFLNIPLHIVDITEEYMDILKNPRFGYGKNMNPCIDCHAFMVKKAKELLKEFNAEFIITGEVLGERPMSQNKQSLKLVEKYSGTEDILLRPLSAKLLPPTKPEREGLVDREKLLDIKGRSRKVQLELAKKIGLKEIPTPAGGCLLTEPNFSRRLKDLLEHNKNMNRRDLELLKIGRHFRLDNNTKVIVGRNKEENEELMYLATEEDTILKAEEPSPIVIVPNKIVENEKELQEIGKITAYYSDHREEPRVKVKVKLGNREKEIEVVPYNKENFPYKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E154</accession>
    <name>B8E154_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative cytidylate kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583266.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352796.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0901"/>
    <dbReference type="EnsemblBacteria" id="ACK42182">
        <property type="protein sequence ID" value="ACK42182"/>
        <property type="gene ID" value="Dtur_0901"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0901"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065155_2_2_0"/>
    <dbReference type="InParanoid" id="B8E154"/>
    <dbReference type="OMA" id="FIHFYFD"/>
    <dbReference type="OrthoDB" id="1962890at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="214" mass="24555" checksum="2BD9EDE37E1266F4" modified="2009-03-03" version="1">MPVITISRQVGSLGDELAERLSKELGYRYFDKFLMTEIAISSGLTEAEVIDFSEDNYKVKGFFEQLFGRKTPVGSVTIKEKDEKGKLVLTTKVFDEESSLAFVQAVIKKLVDWGNVVIVGRGGQVLLRNISHVLHVRVIAPLEFRIENIMRQKGLTREDALKYISEKDRAAQEYLYRFYNVDWNDPELYHIVLNMGMLKIEHAVKVIKELVNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1A8</accession>
    <name>B8E1A8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0956</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583320.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352850.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0956"/>
    <dbReference type="EnsemblBacteria" id="ACK42236">
        <property type="protein sequence ID" value="ACK42236"/>
        <property type="gene ID" value="Dtur_0956"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0956"/>
    <dbReference type="eggNOG" id="COG0010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066809_1_1_0"/>
    <dbReference type="InParanoid" id="B8E1A8"/>
    <dbReference type="OMA" id="ILMFDEY"/>
    <dbReference type="OrthoDB" id="1598732at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, using agmatinase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="PTHR11358"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="235" mass="27621" checksum="859DC8DD228020EB" modified="2009-03-03" version="1">MYNKENFPAYFLCFDDTYFNQRNLIKFGKIIDLRAFTQVKYLCSYDKLEEIGKFVGSEKGIKFLGKSDFHYLTYLFVRNIKVKFNFIVIDHHLDFKNTFDGYISCGSWLRDVLKLPLVEKIFLITSDNNTMKVPNKLIIVNKFSILEDVLRRLPIYISIDKDILDKKYLSTNWEQGNMNLDEFLNLLNFLSHFNVIGVDVCGEPDFNLAEYKKSEQLNLMIYSIFAKNISLKISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1B3</accession>
    <name>B8E1B3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583325.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352855.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0961"/>
    <dbReference type="EnsemblBacteria" id="ACK42241">
        <property type="protein sequence ID" value="ACK42241"/>
        <property type="gene ID" value="Dtur_0961"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0961"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039146_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1B3"/>
    <dbReference type="OMA" id="MKFIIYQ"/>
    <dbReference type="OrthoDB" id="1201040at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="340" mass="38890" checksum="AD68DF32D4EC48DD" modified="2009-03-03" version="1">MKDLSSTIKSGLKISLIITTIVFVVILFITTDSRTWEALKSINGKYLIYVILLNTLSWILSGIRYSILIRGIEGVNLNLIEALQIHLSYYFASSITPTSAGGEPLEIYLLSKKNIKIGQATALSLFRYVINTLTFAIASPLIIYFYSYLFPQNIVRKLVQYSAILFLLVVGGFLFALFKPRPIIRLVSYILIKLRRIPFLKRIHPFKILRVVNKTVRDFHNTLWFFLKEKKLTILGFFFFNLLSWITYFLIAPVLMSAFNLKVNYLSVVLVQIPIFFMMFYVPSPGGSGAIEILISLGFAPFVPKYILGIFIILWRTLTHYLTLLAGAIVLVYILGVKNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1E1</accession>
    <name>B8E1E1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ordered locus">Dtur_0989</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583353.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352883.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0989"/>
    <dbReference type="EnsemblBacteria" id="ACK42269">
        <property type="protein sequence ID" value="ACK42269"/>
        <property type="gene ID" value="Dtur_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0989"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1026"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_5_2_0"/>
    <dbReference type="InParanoid" id="B8E1E1"/>
    <dbReference type="OMA" id="RFQMATS"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="67" mass="7899" checksum="7AE72529C6822310" modified="2009-03-03" version="1">MARRTSELREKTDSELLEELKNLRAELFNLRLQQTTGGLTNPHRIKAVRKDIARILTILRERELKKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1E5</accession>
    <name>RL5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplE</name>
        <name type="ordered locus">Dtur_0993</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583357.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352887.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1E5"/>
    <dbReference type="SMR" id="B8E1E5"/>
    <dbReference type="STRING" id="515635.Dtur_0993"/>
    <dbReference type="EnsemblBacteria" id="ACK42273">
        <property type="protein sequence ID" value="ACK42273"/>
        <property type="gene ID" value="Dtur_0993"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0993"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1030"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1E5"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="OrthoDB" id="1456375at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000142392" description="50S ribosomal protein L5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <sequence length="179" mass="20136" checksum="E5464BD5FAEC38A3" modified="2009-03-03" version="1">MEVLREKYIKEVVPAMMRKFGYKNPMAVPKIEKIVVNIGVSEAVQNPGAIEAAARDLAIITGQKPIVRKARKSIANFHLRKGMPIGLKVTLRGERMYAFLYKLINLALPRVRDFSGVSPNSFDGRGNYSLGLKEQLVFPEIEYDKIDRIRGMDITIVTTAKTDEEAKELLALLGMPFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1F4</accession>
    <name>B8E1F4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ordered locus">Dtur_1002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583366.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352896.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1002"/>
    <dbReference type="EnsemblBacteria" id="ACK42282">
        <property type="protein sequence ID" value="ACK42282"/>
        <property type="gene ID" value="Dtur_1002"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1002"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1039"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1F4"/>
    <dbReference type="OMA" id="GDHAYTF"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="13"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="250" mass="27605" checksum="3510497D461EA57B" modified="2009-03-03" version="1">MNIFLKNKEDIEIMKAGGKILAKILKDMEKELKEGMTTYDLARIAEKLMKNYDVKPAFKGYRGYPEVICVSINEEVVHGIPSKNKYIKSGDIVSIDIGIEYEGFFLDAAKTYPIGEVSPLGLRLIQVTEEALWRGITKAQVGNRLSDISWAIQEYVEKNGFNVIRDFVGHGIGRSLHEPPNVLNYGPPGMGPILKEGLVIAIEPMVVTGSYEVKILENGWTAVTKDGGLAAHFEHTVAITPSGPLVLTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1G2</accession>
    <name>B8E1G2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583373.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352904.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1010"/>
    <dbReference type="EnsemblBacteria" id="ACK42290">
        <property type="protein sequence ID" value="ACK42290"/>
        <property type="gene ID" value="Dtur_1010"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1010"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1047"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="InParanoid" id="B8E1G2"/>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030947">
        <property type="entry name" value="EcfA_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
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            <end position="240"/>
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        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="272" mass="30921" checksum="EEB120D2DEF18651" modified="2009-03-03" version="1">MIKVENLSYIYQPGTSQEKVALKNINLEIPSPSFFCIVGANGSGKSTFARLLNGLYTPTSGDVIVDGMNTKDEKRIWEIRKNVGLVFQNPDNQIIGMTVEEDIAFGCENLGLPPEEIEERINFALKAVGMEEYRKYPPYLLSGGQKQRVAIAGILAMMPKYIVLDEPTTMLDPKGRKEIINIIRRLYEEEKKTIILITHHMEEVIWAEKIVVFFNGEIVDLGTPREIFSKDEKLNEWGLNLPITTRISKCLLERGFNIPHPILTPEELSLWL</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Gowda K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
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    </evidence>
    <sequence length="292" mass="33527" checksum="2ED1E28067861FAE" modified="2009-03-03" version="1">MNRLFSLKKDYGILRSYDFKRNAIRFLYILVYLVSLIAVFIAVFPILWTILSGFKDLREFVNEPKIFPRTYDINKFIETWKILNFGRFYLNSFIVVVGSIFFAVIGNGLLGYALSKIKPKGYKLIYYLLLWSLMIPTTTSIVPLFINIVRLGLQGSFIPLWLSAGANAFFVILYKNFFDSIPQSIIEAARIDGAGEWSIFFKVVFPLSYPINTVITIFTINGAWSDFLLPYLLLNNTGKETVMVRLFQFRTSVATDVDIIRAVTFSIIPPILLFAFFQKYMMEGMTRGGIKG</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
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                <person name="Gowda K."/>
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            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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            <topology evidence="4">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
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    </comment>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
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        </location>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="290" mass="32976" checksum="800C2486E2DABE89" modified="2009-03-03" version="1">MLKKYRRDIAGWLIMLPSIILFIFFLWEPLLASIVMSFYSAKGIRLEKFVGFQNYIEVIQHPDFKAAFLNTFSYTFWSLVIGFLVPIILAIIINEIIHFKGFFRVSVYLPNVIPGLAVAIMWLYIYKAGKTGLLNIILGQLGIPPQAWLTKSHLVIPLIVLFMTWRSAGATTLIYLARLQGIDPELYEAATIDGAGIWQRLRYITLPQIYNLARTLLILQVIFVFQVLYEPLVLTNGGPNNASTTLMLLVYKYAFEKFDYPKAASISVIIALILVLLTAVYNKLVKENEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1I4</accession>
    <name>B8E1I4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutamine synthetase, type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0180</name>
    </gene>
    <organism evidence="5 6">
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        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
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                <person name="Gowda K."/>
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            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
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    <dbReference type="EMBL" id="CP001251">
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    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0180"/>
    <dbReference type="EnsemblBacteria" id="ACK41509">
        <property type="protein sequence ID" value="ACK41509"/>
        <property type="gene ID" value="Dtur_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0180"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.186"/>
    <dbReference type="eggNOG" id="COG0174">
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    </dbReference>
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    <dbReference type="OMA" id="TFYTHPE"/>
    <dbReference type="OrthoDB" id="416474at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="4">
        <location>
            <begin position="108"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="2">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="446" mass="51452" checksum="C89214C6347A1FCB" modified="2009-03-03" version="1">MANSFPKTKEEILKYVKENNVYFIEIWFADILGYLKSFTITAHELEKAFEEGLGFDGSSVRGFTRIEESDMIAFPEPETFTILPWRPQDKKVARMFATIVEPSGKPFEGDPRNVLRRVLSRAKEMGFTYYVGPELEYFYFKSPSPNLEVLDWGGYFDLIPRDEAIDLRHQTVSMLEEMGIEVEFTHHEVAPSQHEIDFRYAEALTMADTVMTARLAIKEVAYLNGVYATFMPKPLFGQNGSGMHVHMSLFKDGKNAFFDPHDKYHLSDTAKHFIAGLLKHAKEITLITNQWVNSYKRLVPGYEAPVYISWAMRNRSDLIRVPMYKPGKEEATRIEYRAPDPACNPYLAFAVMLAAGLEGIEKKYPLPEPVEENVYHMTEEERKKKGIESLPGSLIEAIEITEKSEVVKKALGEHVFTNFIENKKIEWDNYRRQVTTYELETYLPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1J5</accession>
    <name>B8E1J5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582605.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352134.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0191"/>
    <dbReference type="EnsemblBacteria" id="ACK41520">
        <property type="protein sequence ID" value="ACK41520"/>
        <property type="gene ID" value="Dtur_0191"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0191"/>
    <dbReference type="HOGENOM" id="CLU_823180_0_0_0"/>
    <dbReference type="OMA" id="AWIRMEK"/>
    <dbReference type="OrthoDB" id="2106478at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="337" mass="39445" checksum="4AFF552ACC687047" modified="2009-03-03" version="1">MKFPKGKPIYEDTPSGLINLKELVAWIRMEKFDGVLEGKISDIRTQILITEGEPRKAFTYKDSELLLQDDEAIDSFVTDAMMRVSCISLYNLEERIIKSILLKLFSNPVLNGDLKIFDPSGIIDKCLEKSNISHLNLILDVNNFHFLFYNGKYLGYYNEKDGEFIEDEEKIGLIQNLNSKMGYLYFYNMPIKDFEKLKFPSLKFGEIEKNVDFLIETLIEFLNQLITTYVNIGIYPDRVRKIVEKIFSSQNGLMKDSFILVEDQFMIRQNVISSWYEAVNLFSDFIKNLNGELVKLWGKKLLNEKYTEVYKNYYEKIKNHPELSNLFSYLSPENINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1M6</accession>
    <name>B8E1M6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-N-acetylhexosaminidase</fullName>
            <ecNumber evidence="3">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582636.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352165.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0222"/>
    <dbReference type="CAZy" id="GH20">
        <property type="family name" value="Glycoside Hydrolase Family 20"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41551">
        <property type="protein sequence ID" value="ACK41551"/>
        <property type="gene ID" value="Dtur_0222"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0222"/>
    <dbReference type="eggNOG" id="COG3525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_495781_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1M6"/>
    <dbReference type="OMA" id="DETWALG"/>
    <dbReference type="OrthoDB" id="727559at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102148">
        <property type="term" value="F:N-acetyl-beta-D-galactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="PTHR22600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_20" evidence="5">
        <location>
            <begin position="97"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="571" mass="67454" checksum="5A0D8328AB392E61" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Q1</accession>
    <name>B8E1Q1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transport system permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582661.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352190.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0250"/>
    <dbReference type="EnsemblBacteria" id="ACK41576">
        <property type="protein sequence ID" value="ACK41576"/>
        <property type="gene ID" value="Dtur_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0250"/>
    <dbReference type="eggNOG" id="COG0609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1Q1"/>
    <dbReference type="OMA" id="MMSSWKL"/>
    <dbReference type="OrthoDB" id="1283908at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="340" mass="37019" checksum="0B7EE5B2480E15AD" modified="2009-03-03" version="1">MEYKITVKEYKEYTGRKILFIFLLGFFTIIFSIFALNVGSSGINLLDFVRAFLGKGEGKLGLIVWQIRIPRVLGAILAGIGLGVSGCISQNVLRNPMASPFTLGISQGAALGATLSIVLFNQNIPYLTPLFAFLGAMMTTVLIILLSSRFKVTPEAMILAGVSLSSLFSALTTIIQYFANEVKIAAVIFWTFGDIGRISLKDIKIIFIVILLGTLYFVSRRWDYNSLEGGDETAKSLGINVERERIVSMLITSLISAVITASVGVIGFVGLIAPHIMRRFVGNDYRFLIPGSALFGGLLLLVSDTLARTVISPIVLPVGAITSLLGAPFFLYLLSLRFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1S4</accession>
    <name>B8E1S4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0403</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582792.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352321.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0403"/>
    <dbReference type="EnsemblBacteria" id="ACK41707">
        <property type="protein sequence ID" value="ACK41707"/>
        <property type="gene ID" value="Dtur_0403"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0403"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.424"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1S4"/>
    <dbReference type="OMA" id="TCVCFFG"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="120"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="351" mass="40249" checksum="5C509C2AD9CB186E" modified="2009-03-03" version="1">MISPKEGKCKVCGKESILISSFLGVCRDCILNRFDEALPIIESAHKRARTYFDLSYPAYSQKPYCDICIHKCALDSEKSFCGLIENSIRWAGSSEKGLLEWYYDPLPTNCVATFICPEKEHYGYKNLAIFYASCNFNCLFCQNWHFHDYLKRRSPIYSVEDLIGKIDDKTSCICFFGGDPTTQIAHALALAKKVKNRVRICWETNGSMNLKILKEMFYISVESEGIIKFDLKAFDERIHIALTGVSNKNTLENFRWVGEKSKEIKDRVVVVASTLLIPGYVNEEEVEKIVDFIVNINPNIPYSLLGFAPNFFFDNLPTTSKAHAERSFKLAREKGLKYVNIGNRFLLSHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1T2</accession>
    <name>B8E1T2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582800.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352329.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0411"/>
    <dbReference type="EnsemblBacteria" id="ACK41715">
        <property type="protein sequence ID" value="ACK41715"/>
        <property type="gene ID" value="Dtur_0411"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0411"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.434"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="InParanoid" id="B8E1T2"/>
    <dbReference type="OMA" id="GFGFCPE"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="242"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="494" mass="55885" checksum="89DF4BF7122F076D" modified="2009-03-03" version="1">MENINKSFPGVQALKDAYFELNKGEVHALVGENGAGKSTLMKILVGAYRKDSGRIIYKGKEVDIPNPRVAQEMGISMVFQELNLMPHLTVAQNIFIGREPKRKNLPIFLDDDEINKRTKELLNMLHLKVEPNVKVSNLSVGKQQMVEIAKALSFNSEVIIFDEPTAALSEAETEELFSVIRKLKSQGIGIIYISHRLEELREIADRVTVMRDGQYIGTDYMKNLTIEKIISMMVGREIYETLREKEVEENAEVVLEVRNLKRSKVFRDISFSLRKGEILGFAGLIGAGRTEVARAIFGADPVDSGEVYVKGKKVHIRNPWDAISHGIAYLSEDRKRYGLMPDLDVKSNIILPSMKDFLKALGFVDDKKAEKVSNEYIQRLRIRTPSVRQKVKNLSGGNQQKVVVAKWLLRNCDILIFDEPTRGIDVGAKNEIYKLLNELIAEGKSIIMISSELPEILRMSHRIVVMCEGRITGILDADEATEEKILKYATMYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1U5</accession>
    <name>B8E1U5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582813.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352342.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0425"/>
    <dbReference type="EnsemblBacteria" id="ACK41728">
        <property type="protein sequence ID" value="ACK41728"/>
        <property type="gene ID" value="Dtur_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0425"/>
    <dbReference type="eggNOG" id="COG4221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_0"/>
    <dbReference type="InParanoid" id="B8E1U5"/>
    <dbReference type="OMA" id="EILVGWQ"/>
    <dbReference type="OrthoDB" id="1261526at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="241" mass="27348" checksum="1D129914EABCCF8E" modified="2009-03-03" version="1">MRSLENKIALITGASRGIGEEIAKRLAKEKVNLALIARDEKRLRELKEKLEKENINVFILSIDLREKNAPKTVIGEVIRHFERLDILINNAGTALSKPIIETSEEEWDEIMTINAKVPYFLCKYAIPYLKNSEIPTIINISSVVGYKGYVNQSAYTASKHALHGFTKVLAQEVHEYGIRVHLISPGGVATDLVNKVRPDLEKALLIQPSEIAEIIVFLLKFRNNAVIDEIQVRRKDNIPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1U7</accession>
    <name>B8E1U7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbohydrate kinase FGGY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582815.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352344.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0428"/>
    <dbReference type="EnsemblBacteria" id="ACK41730">
        <property type="protein sequence ID" value="ACK41730"/>
        <property type="gene ID" value="Dtur_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0428"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.452"/>
    <dbReference type="eggNOG" id="COG1070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039395_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1U7"/>
    <dbReference type="OMA" id="MPDLFNY"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008993">
        <property type="term" value="F:rhamnulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019301">
        <property type="term" value="P:rhamnose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07771">
        <property type="entry name" value="FGGY_RhuK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013449">
        <property type="entry name" value="Rhamnulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0684">Rhamnose metabolism</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="3">
        <location>
            <begin position="256"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="493" mass="56196" checksum="ADE4A8144C23B697" modified="2009-03-03" version="1">MEERKFLAIDLGAESGRLIVGILRDGRLAIEEVHRFINRPVDILGRLYWNVTQMFQDIKDGLVKAFSKYKDIESIGIDTWGVDFGLVTKEGYFAGIPVCYRDHRTDGILEKAFEVMPKERIYELTGIQIMQINTLFQLYSMVLENSSLFNSTYKLLFMPDLFNFMLTGEIKTEFSIATTSQIYNPIKDGWEEEILRKFSIPKDIMPEVVPPGTVIGKLYKGIEEDLGVKNIHVIAPCEHDTGCAVVGVPGEGDDWAYISSGTWSLMGVELKSPIINNDSLRANFTNEGGYNKTFRFLKNIMGLWLLQRVKREWAKEGEDLSYTEITRLAEEEKPFKYFINPDDVSFLNPTSMVKEIQDYCKKTGQKVPEKKGEIVRCILESLAFRYKDVFTDLERILNKKIKVLHIVGGGSQNQLLSQFTADVLGIPVITGPKEATALGNIVVQAITKGVVKDIIEARKIIRDSSEMKVYQPQNTEEWLRNYEKYKEITQGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Z0</accession>
    <name>B8E1Z0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582858.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352387.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0473"/>
    <dbReference type="EnsemblBacteria" id="ACK41773">
        <property type="protein sequence ID" value="ACK41773"/>
        <property type="gene ID" value="Dtur_0473"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0473"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.499"/>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_2_0"/>
    <dbReference type="InParanoid" id="B8E1Z0"/>
    <dbReference type="OMA" id="YLDGMIW"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="245"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="515" mass="58597" checksum="16EAE938796AFB3F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E218</accession>
    <name>B8E218_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582886.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352415.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0508"/>
    <dbReference type="EnsemblBacteria" id="ACK41801">
        <property type="protein sequence ID" value="ACK41801"/>
        <property type="gene ID" value="Dtur_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0508"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.539"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_2_4_0"/>
    <dbReference type="InParanoid" id="B8E218"/>
    <dbReference type="OMA" id="WVSAVWA"/>
    <dbReference type="OrthoDB" id="534010at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="421" mass="47292" checksum="9A27BE738D539DC8" modified="2009-03-03" version="1">MKKFSIILITLFVLVLLSIGGAQEKPKITIWAWDPNFNIPIMQEAAQRYKKINPNVDFDIVSMAKADVEQKLNTVLASGVKTNLPEIVLIEDYNAQKYLTSYPGAFADLTNHFNYKEFAPYKVQLMTVKGRVYGVPFDSGVTGWFYRRDYFKQAGLDPAKLQNITWEKFIEIGRTLKQKTGKYMISGDPFDGGLMRILLHSAGSWYFDKDGNITISNNEVLKEAVKLYKTLRDSGISKEVSGWNEWVASFNSGEVASVITGVWIIGSIKAAKDQSGKWGVLPIPRLNVPGAVNASNLGGSSWYVLQNSRYRDVAIDFLKQIYAKDVDFYQKILIERGAVGTWLPAQRGSAYTAADPFFGNQKVFTYFSTWMRKVPAINFGLYTYEADAAIMGVMPDVYNGKLTIDEALKKAEEQLKNTIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E221</accession>
    <name>B8E221_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583381.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352912.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1018"/>
    <dbReference type="EnsemblBacteria" id="ACK42298">
        <property type="protein sequence ID" value="ACK42298"/>
        <property type="gene ID" value="Dtur_1018"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1018"/>
    <dbReference type="HOGENOM" id="CLU_1892889_0_0_0"/>
    <dbReference type="OMA" id="DSPWREK"/>
    <dbReference type="OrthoDB" id="2122656at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="134" mass="15869" checksum="D2CE3DCA378F3CA1" modified="2009-03-03" version="1">MREVLRNKKLRNYLILFLTLLIFLAYSYYDWLKDSPWREKWKNLEKYVGKEVTLKGEAVSPYGIWGSIYSAYSLTFENFQITVLSTTGIPAEGENLIVTGEIKKNFEVVGFWQGKEVRESYPMVLIEKERREIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E227</accession>
    <name>YQGF_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative pre-16S rRNA nuclease</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_1024</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YqgF nuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583387.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352918.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E227"/>
    <dbReference type="SMR" id="B8E227"/>
    <dbReference type="STRING" id="515635.Dtur_1024"/>
    <dbReference type="EnsemblBacteria" id="ACK42304">
        <property type="protein sequence ID" value="ACK42304"/>
        <property type="gene ID" value="Dtur_1024"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1024"/>
    <dbReference type="eggNOG" id="COG0816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098240_2_1_0"/>
    <dbReference type="InParanoid" id="B8E227"/>
    <dbReference type="OMA" id="PMGWTAQ"/>
    <dbReference type="OrthoDB" id="2075502at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000967">
        <property type="term" value="P:rRNA 5'-end processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16964">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00651">
        <property type="entry name" value="Nuclease_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005227">
        <property type="entry name" value="YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33317">
        <property type="entry name" value="PTHR33317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03652">
        <property type="entry name" value="RuvX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00250">
        <property type="entry name" value="RNAse_H_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_1000131026" description="Putative pre-16S rRNA nuclease">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00651"/>
        </source>
    </evidence>
    <sequence length="141" mass="16470" checksum="67E82C63D595A794" modified="2009-03-03" version="1">MRVLAIDWGEKYIGLAISDPLRIIAQGLDVWEIKDEEDFVNRLKKLIKEYNVSEIVLGYPISLRGHENEKTKKIEYVAERIKTVVNLPIKFVDERFTTMEAERVLLEGDIKRRDRKLLKNKQAAVIILQKYLDSLSLDTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E252</accession>
    <name>B8E252_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_1049</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583412.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352943.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1049"/>
    <dbReference type="EnsemblBacteria" id="ACK42329">
        <property type="protein sequence ID" value="ACK42329"/>
        <property type="gene ID" value="Dtur_1049"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1049"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1086"/>
    <dbReference type="eggNOG" id="COG0686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_0"/>
    <dbReference type="InParanoid" id="B8E252"/>
    <dbReference type="OMA" id="HPYYHLY"/>
    <dbReference type="OrthoDB" id="673280at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006524">
        <property type="term" value="P:alanine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008143">
        <property type="entry name" value="Ala_DH/PNT_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00837">
        <property type="entry name" value="ALADH_PNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="11">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="10">
        <location>
            <begin position="149"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="267"/>
            <end position="270"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="374" mass="40663" checksum="DE7E86F1A4410167" modified="2009-03-03" version="1">MIIGIPKEIKPEENRVAIVPGGVETLVKRGHKVLIEKGAGFGSGFSDEEFAKAGAVIVERHEDVFYEAELILKVKEPLPEEYNLLSEGKILFTYLHLAASQDLTMNLLKRKIIGIAYETVQTDDGFLPLLAPMSEIAGRMAPQEGAKYLEKTFGGRGILLGGVPGVPPANVVIIGAGNVGFNSARIAYGMGASVTVLDINPRKLRFIDDYFQGKVITMFADEYNVRMAIEYADLVIGAVLVPGAKAPKIITRELLKNMKKGSVLVDVAIDQGGCAETSRPTTHRDPIYEEEGVIHYTVANMPGAVPRTSTRALTLNTLPYVIEIADKGWKRAVMENRSLSRGVNIAYGKITHEEVAKAFDLPYVPLEEVIKGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E255</accession>
    <name>B8E255_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polar amino acid ABC transporter, inner membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583415.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352946.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1052"/>
    <dbReference type="EnsemblBacteria" id="ACK42332">
        <property type="protein sequence ID" value="ACK42332"/>
        <property type="gene ID" value="Dtur_1052"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1052"/>
    <dbReference type="eggNOG" id="COG0765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019602_1_1_0"/>
    <dbReference type="InParanoid" id="B8E255"/>
    <dbReference type="OMA" id="IGLHYST"/>
    <dbReference type="OrthoDB" id="1523519at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010065">
        <property type="entry name" value="AA_ABC_transptr_permease_3TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043429">
        <property type="entry name" value="ArtM/GltK/GlnP/TcyL/YhdX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30614">
        <property type="entry name" value="PTHR30614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01726">
        <property type="entry name" value="HEQRo_perm_3TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="7">
        <location>
            <begin position="19"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="218" mass="24153" checksum="724A75B3177CD8D7" modified="2009-03-03" version="1">MDFNINIFIESIPYLLKGAVVTLRLSVISVAFGIILGLFLGLARISKNYLLRIPSTIYVEVIRGTPLLMQLLIIYYALPSFGINLGAITAAIVGLSLNSAAYTGEIFRSGIQSIDKGQMEAARSLGMTYFQAMRYIILPQAFRRILPPLTNEFVSMLKESSLASTLAVTELLRAGREIVAWKANVFSPFLGVTLIYLLMTLPLTRLSVWLEKRLKTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E266</accession>
    <name>B8E266_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1063</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583426.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352957.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1063"/>
    <dbReference type="EnsemblBacteria" id="ACK42343">
        <property type="protein sequence ID" value="ACK42343"/>
        <property type="gene ID" value="Dtur_1063"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1063"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_0"/>
    <dbReference type="InParanoid" id="B8E266"/>
    <dbReference type="OMA" id="IKEQTYV"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="258"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="460" mass="52837" checksum="22C9D1F77B380250" modified="2009-03-03" version="1">MDNMEFTSSYSLKGILREVLRYKTGVFSLLIFAILILLSVYAYLSMPYDKAKELWNDSQAWLKYPRNAIPTWLAFFTGKNLPKNIYLKDPKIESVSETPKIVKYVYDINYTYDDFPSEFNIFLNSTFKNNPPNLRIYWINPYGDRILLFEKVQRAEKDIFYIGNESSIEQKFIEYYKEKLGFYPNFPVTVMRGLFGETENPKVNKGNYKLEIEVQFTDKSDTIEIEPIIYGKVYGVAGTDHLRRPLELGILYGTPIDLAFGLGASLSITVIQLILATVSGWYGGWVDNLIQRLTEIYMLLPFLPLMIMISLFYKLTIWQLLVVLIILSLFGSGIKTQRAMVLQVKTLPYIEAARTYGASNMRIVFLYIIPKILPPVIPGLIISIPAYIFLEAILSLFGVLDPTEPTLGRIIEEAFQNGALYKGFYYWVIEPSLIIVLLAISFALLGFVIDRIVNPRLKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E276</accession>
    <name>B8E276_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">argR</name>
        <name evidence="11" type="ordered locus">Dtur_1074</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulates arginine biosynthesis genes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis [regulation].</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583436.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352967.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1074"/>
    <dbReference type="EnsemblBacteria" id="ACK42353">
        <property type="protein sequence ID" value="ACK42353"/>
        <property type="gene ID" value="Dtur_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1074"/>
    <dbReference type="eggNOG" id="COG1438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097103_3_0_0"/>
    <dbReference type="InParanoid" id="B8E276"/>
    <dbReference type="OMA" id="IMGTICG"/>
    <dbReference type="OrthoDB" id="1640037at2"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034618">
        <property type="term" value="F:arginine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00173">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001669">
        <property type="entry name" value="Arg_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020899">
        <property type="entry name" value="Arg_repress_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036251">
        <property type="entry name" value="Arg_repress_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020900">
        <property type="entry name" value="Arg_repress_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34471">
        <property type="entry name" value="PTHR34471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01316">
        <property type="entry name" value="Arg_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02863">
        <property type="entry name" value="Arg_repressor_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01467">
        <property type="entry name" value="ARGREPRESSOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55252">
        <property type="entry name" value="SSF55252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01529">
        <property type="entry name" value="argR_whole"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Arg_repressor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Arg_repressor_C" evidence="10">
        <location>
            <begin position="77"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="149" mass="16990" checksum="55F2E16672ED39AB" modified="2009-03-03" version="1">MNKKERLEKIKEILKKRNISSQKELMEALREEGIYVVQATLSRDLKELGVIRQSSDLGKRYIIPENAINVASLKDLFHRVVVSIDFAENLILVKTIPGNAQAVAFLLDNFLNVYDYFVGSVAGDDTILIVLRSKDKTQEALEKLEELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8E283</accession>
    <name>B8E283_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="10" type="ordered locus">Dtur_1081</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583443.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352974.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1081"/>
    <dbReference type="EnsemblBacteria" id="ACK42360">
        <property type="protein sequence ID" value="ACK42360"/>
        <property type="gene ID" value="Dtur_1081"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1081"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1117"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_0_1_0"/>
    <dbReference type="InParanoid" id="B8E283"/>
    <dbReference type="OMA" id="AEMKTGR"/>
    <dbReference type="OrthoDB" id="1592033at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006809">
        <property type="entry name" value="GTP-binding_hflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="9">
        <location>
            <begin position="186"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="217"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="239"/>
            <end position="242"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="305"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="331"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006809-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="405" mass="46982" checksum="F976F80587056D37" modified="2009-03-03" version="1">MEIEKAILVAKISDLEELEELKLLSKTAGVKVQNVLLFGGEPDPASFLRSGKLEELKYLVMEQRADLVIFNNDLSPVQLRNIEKEIPARIVDRTMLILDIFAQHARSKEGKIQVELAQLEYLLPRLTGRGETLSRLGGGIGTRGPGETKLEIDRRKIRKRIHTLKKELEEIKREREVQRKQRLNLPQIALVGYTNAGKSTLFNLLTGANVRAEDLLFATLDPTVRKVNFKNNWEVLISDTVGFIRNLPEELLTAFRATLEEIYYVDLILHVIDISDKDFRKQIEVVESILEDMGIEDKTIIRVYNKIDLLSKEEVRYLKQELDYKPSVFISAKEGIGIEKLKDLIVNELLKGVRRYKINIPYNKFNLFQKYRGKLYIEEENYKENFVEIKARVPKEYKKLLDELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2F2</accession>
    <name>B8E2F2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA double-strand break repair RAD50 ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583872.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353410.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1522"/>
    <dbReference type="EnsemblBacteria" id="ACK42796">
        <property type="protein sequence ID" value="ACK42796"/>
        <property type="gene ID" value="Dtur_1522"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1522"/>
    <dbReference type="HOGENOM" id="CLU_1270634_0_0_0"/>
    <dbReference type="OMA" id="YENFLWE"/>
    <dbReference type="OrthoDB" id="2116802at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="217" mass="26240" checksum="D3C91A821BA85D0C" modified="2009-03-03" version="1">MRDLLERIYLPFSWGKETLFYFYHFQKGEEEKLIKSFNYFKDFQNWMIKNKSKFNKLIRRLNEIKDLRGEILVTLRTTENLNNISLIIDDIKNLICQENIILPEDILIPDMKYLSYENFLWEVLSFYLKMTKFITFAINFDKFPKLSERFKGKKLYKYNTPYKMEEEKSFLQNLILAICGVPGFEEIEFSLLNSISPKRNSLPETLEIKDDIFIFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2F7</accession>
    <name>B8E2F7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA protecting protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583877.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353415.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1527"/>
    <dbReference type="EnsemblBacteria" id="ACK42801">
        <property type="protein sequence ID" value="ACK42801"/>
        <property type="gene ID" value="Dtur_1527"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1527"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1576"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_0_3_0"/>
    <dbReference type="InParanoid" id="B8E2F7"/>
    <dbReference type="OMA" id="SEMPFGW"/>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="364" mass="41373" checksum="6A8DB7043934001D" modified="2009-03-03" version="1">MYQFRVEDKPFIYALSFFSPLFRRWREWIDIISPKELFFLSESELINLFSGSSLIQEFIVFKRRFNWEKEWEKLEKHCIKMVTLWEEDFPPLLKEIKNSPPLLLYKGSIEGEKFIGIVGTRRPSAYGVKMAESFARELVKYGFVVVSGLAYGIDTYAHKGAIEGGGKTFAVLGSSLDHIYPSGNLKLAEKIMESGAIISEYPLGTRPARYTFPQRNRIISGICQGILVVEAGEKSGALITAGFAANEGRDVFAIPGRLTDEKSIGTNKLIKDGAKMVIDIGDILEEYNIPYEVRKEKDFELTEEEKLVLNFLGLEPIFIEDLMKNLNIDLSRLMFIIISLQGKGFVEEYPGLRYAKKRSVIIDG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2G0</accession>
    <name>Y1530_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0102 protein Dtur_1530</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_1530</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583880.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353418.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2G0"/>
    <dbReference type="SMR" id="B8E2G0"/>
    <dbReference type="STRING" id="515635.Dtur_1530"/>
    <dbReference type="EnsemblBacteria" id="ACK42804">
        <property type="protein sequence ID" value="ACK42804"/>
        <property type="gene ID" value="Dtur_1530"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1530"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1579"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_2_3_0"/>
    <dbReference type="InParanoid" id="B8E2G0"/>
    <dbReference type="OMA" id="RNWRCGR"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000200137" description="UPF0102 protein Dtur_1530">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <sequence length="118" mass="13851" checksum="A57B4887CCBAFFB2" modified="2009-03-03" version="1">MNNKEIGKLGEDFTVEFLSSRGFIVLERNYKVSFGEIDIIARKGDILIFVEVKTRRNLDFGMPVESVSFEKQNRIKKIAEIYVKNKQLRFKEIRFDIMSIILSPKGEVLNWEYLPNAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2H4</accession>
    <name>Y1544_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative nickel insertion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_1544</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LarC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583893.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353432.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2H4"/>
    <dbReference type="SMR" id="B8E2H4"/>
    <dbReference type="STRING" id="515635.Dtur_1544"/>
    <dbReference type="EnsemblBacteria" id="ACK42818">
        <property type="protein sequence ID" value="ACK42818"/>
        <property type="gene ID" value="Dtur_1544"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1544"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1593"/>
    <dbReference type="eggNOG" id="COG1641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028523_2_1_0"/>
    <dbReference type="InParanoid" id="B8E2H4"/>
    <dbReference type="OMA" id="TCLGLDW"/>
    <dbReference type="OrthoDB" id="1547060at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000136689" description="Putative nickel insertion protein">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <sequence length="389" mass="43866" checksum="7663C3EE2D726995" modified="2009-03-03" version="1">MKVLYFDCFSGISGDMILGALLDLGVNLEEWKNELNKIPVEGYKIEISKKQKNHIWGTDVEIIIEDHHSHRHLEDLLEIVDKSELSENIKNRAKEVFYKIAEAEAKIHNTSINEVHFHEVGALDTVIDVLGSLILLDMLKVDKIYSSPLPLGGGFVNASHGTIPVPAPATLEILRGVPVYRDGREGELVTPTGAAIISTIAEFVKILPPIKVDKVGYGCGKKDFPFPNLLRVYEGELIEKVIEEKNVVLETNIDDMNPQIFGYLTEKLFKEGALDVFLTPVYMKKGRPGVLLTVIAPLAMEEKLLEVIFGETTTLGVRRIYVDKRIMQREIREIETKWGKVRIKVANINGIKKAYPEYEDCKSIAERENIPLKDVIGEIEKIIERELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2H6</accession>
    <name>B8E2H6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583895.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353434.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1546"/>
    <dbReference type="EnsemblBacteria" id="ACK42820">
        <property type="protein sequence ID" value="ACK42820"/>
        <property type="gene ID" value="Dtur_1546"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1546"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1595"/>
    <dbReference type="HOGENOM" id="CLU_400499_0_0_0"/>
    <dbReference type="OMA" id="ILTRCNI"/>
    <dbReference type="OrthoDB" id="2105159at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="687" mass="81368" checksum="464447C8A37459D7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2I8</accession>
    <name>B8E2I8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583907.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353446.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1558"/>
    <dbReference type="EnsemblBacteria" id="ACK42832">
        <property type="protein sequence ID" value="ACK42832"/>
        <property type="gene ID" value="Dtur_1558"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1558"/>
    <dbReference type="eggNOG" id="ENOG5033YUV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677452_0_0_0"/>
    <dbReference type="OMA" id="NDSEPPD"/>
    <dbReference type="OrthoDB" id="2107504at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867829" evidence="1">
        <location>
            <begin position="22"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="406" mass="44083" checksum="B54A7CB4490B76AC" modified="2009-03-03" version="1">MKKRFLPLLILAIFLMSISYAATTTFSYKDLLYDPRAMGMAGAMTALADSPTSAIYNPALMGEYSRLAFKFGFGIAPLDEQNFNNLNTFVEYLQLLQNDSEPPDGKLSFNLSSAGYLHLGISKLGLTLFGDGDVDAYYYKYTASDSSADLQLEGQVSLDANVKANGALTVAIPAIDLLGLKVNFGANVRAVNEYYVDTSISTKVTQTGVTEATLTGGPNENDYYERKFDLIEQRYVSFDLGTYVRFSPFVAAGIVVKDVYAIPLEGKETFGYEKGYYYLDSGTGNPTYSTVTPYSETPTPIDVVLPDMSLKAGVFVKVPVLGTRVSVDADLDKTFTPLSYRFGIEQPLFFVLTARGGAVLDTNFQPQLYTLGLGLNVLLIQADAAIAIDPQVMAPVAGSISGSIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2K2</accession>
    <name>B8E2K2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="9">DHOD</shortName>
            <shortName evidence="9">DHODase</shortName>
            <shortName evidence="9">DHOdehase</shortName>
            <ecNumber evidence="9">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrD</name>
        <name evidence="11" type="ordered locus">Dtur_1572</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="9">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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        <property type="protein sequence ID" value="ACK42846"/>
        <property type="gene ID" value="Dtur_1572"/>
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        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
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        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
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        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
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        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
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        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
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        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 9" id="KW-0288">FMN</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="10">
        <location>
            <begin position="5"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="191"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="45"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
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    <feature type="binding site" evidence="9">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="264"/>
            <end position="265"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="306" mass="33892" checksum="725C3A3AB80F0ACF" modified="2009-03-03" version="1">MSKVQVKVGSLTFKNPILLASGTCGNGKEINKFYNINILGGFVTKSITINPREGNPNPRIWESYAGILNSIGLENAGLDKFLEEEIPFLEKLNTNVIVSIAGEKKEEYYEIARVLRECKISGIEINLSCPNVEGGGMLFGIDSEMVKEITKNVVNIVDKPVWVKLTPQAKDIIGVAKAVRSAGGEAVVVFNTFLGLAIDWKKREPVFKRIFAGYSGPAIKPIVLRYVWELYEENILPIVGCGGIVNFTDVLEYIFAGASLVQIGSANFRDPWIGEKIVKEVQNYFKEEKVVDLIGIAHKNHEEVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2T9</accession>
    <name>B8E2T9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">G3P acyltransferase</fullName>
            <shortName evidence="10">GPAT</shortName>
            <ecNumber evidence="10">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="10">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">plsY</name>
        <name evidence="11" type="ordered locus">Dtur_1160</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583521.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353053.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1160"/>
    <dbReference type="EnsemblBacteria" id="ACK42439">
        <property type="protein sequence ID" value="ACK42439"/>
        <property type="gene ID" value="Dtur_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1160"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1197"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_7_1_0"/>
    <dbReference type="OMA" id="WRHRGNL"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="201" mass="22318" checksum="1F6B213E3785D3A7" modified="2009-03-03" version="1">MFLKILLVILSYLIGSIPSALIVGKLWKGIDVRNYGSGNLGATNVLRVLGWGPAVIVAVMDVGKGILAVYLAQSFLHSDYLFVLLCVIAAVIGHSFPIFAGFRGGRSVGVSFGILFYLFPKSSLIIFFIAIIIVAVTQYKSVASITSALIYPFLLYHIEKPPMEYFIGVILVCLFIIYRHIPNIKRLIKGEEHKISWKVRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2U4</accession>
    <name>GATC_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name type="ordered locus">Dtur_1165</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583526.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353058.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2U4"/>
    <dbReference type="SMR" id="B8E2U4"/>
    <dbReference type="STRING" id="515635.Dtur_1165"/>
    <dbReference type="EnsemblBacteria" id="ACK42444">
        <property type="protein sequence ID" value="ACK42444"/>
        <property type="gene ID" value="Dtur_1165"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1165"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_6_1_0"/>
    <dbReference type="InParanoid" id="B8E2U4"/>
    <dbReference type="OMA" id="VTPMAMK"/>
    <dbReference type="OrthoDB" id="1780195at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000117634" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <sequence length="100" mass="11862" checksum="AB662138976513E4" modified="2009-03-03" version="1">MEKRDFKEQLKKTAHLARLYLTPEEEELYAKQLQDILDYFKKLQEVDTSNIEPMAHVLSLSNIWREDEPKGSISQEEAFKNAPEIENLGFKIPRIIKREE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2W8</accession>
    <name>ILVC_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="1">KARI</shortName>
            <ecNumber evidence="1">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="1">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ketol-acid reductoisomerase type 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ketol-acid reductoisomerase type I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ilvC</name>
        <name type="ordered locus">Dtur_1189</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583550.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353082.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2W8"/>
    <dbReference type="SMR" id="B8E2W8"/>
    <dbReference type="STRING" id="515635.Dtur_1189"/>
    <dbReference type="EnsemblBacteria" id="ACK42468">
        <property type="protein sequence ID" value="ACK42468"/>
        <property type="gene ID" value="Dtur_1189"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1189"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1226"/>
    <dbReference type="eggNOG" id="COG0059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2W8"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="OrthoDB" id="188901at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000190951" description="Ketol-acid reductoisomerase (NADP(+))">
        <location>
            <begin position="1"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="2">
        <location>
            <begin position="2"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="3">
        <location>
            <begin position="183"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="25"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="83"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <sequence length="332" mass="37185" checksum="24BB25DCE10EA163" modified="2009-03-03" version="1">MAKVYHDTEVSLEALKDKIVTIIGYGSQGRAHALNLRDSGIKVIVAVRPNGESWKRALEEGMTVEKIEDAVQKSDVLMFLIPDTEQPTIYKEKVLPYLRPNQALGFAHGFNIHFSQIVPPPFLDVFMVAPKGPGPLVRDLYVEGKGVPALFAVYQDYTQKCRDIALAYAKGIGATRAGVLETTFKEETETDLFGEQVVLCGGVTALIKAGFETLVEAGYQPEVAYYECLHEMKLIVDLINQGGISFMRKAISDTAKYGDITRGPRIVNEETKKEMRKILNEIQSGQFAKEWILENQVGRPVFNALLKKDEDHLIEKVGKVLREMMPWLKPKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Y2</accession>
    <name>RS2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsB</name>
        <name type="ordered locus">Dtur_1203</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ACK42482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    <dbReference type="STRING" id="515635.Dtur_1203"/>
    <dbReference type="EnsemblBacteria" id="ACK42482">
        <property type="protein sequence ID" value="ACK42482"/>
        <property type="gene ID" value="Dtur_1203"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1203"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1241"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_2_0"/>
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    <dbReference type="OMA" id="SYIDRAY"/>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000119423" description="30S ribosomal protein S2">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <sequence length="246" mass="28378" checksum="C3FF3807609EC17E" modified="2009-03-03" version="1">MAHILMKQLLEAGVHFGHQTKRWCPKMKEYIFSERNGIHIIDLQKTLVKLEEAYEFAKEQAKEGKTFLFVGTKKQAQQTIEEEAKRCGAFYVNQRWLGGMLTNFTTIKSRIDYMIKLEELKNNGYFDKLPKKQANRLNRELEKLIKVFDGLRGIERIPDVLYIVDPKREEIAVKEANKLGIPIIAIVDTNCDPELITYPIPGNDDAIRSIKLITSKIADAILEGRDLREKEADLQLKDEDLQSEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E302</accession>
    <name>B8E302_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Redoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1223</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353116.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1223"/>
    <dbReference type="EnsemblBacteria" id="ACK42502">
        <property type="protein sequence ID" value="ACK42502"/>
        <property type="gene ID" value="Dtur_1223"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1223"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_2_0"/>
    <dbReference type="InParanoid" id="B8E302"/>
    <dbReference type="OMA" id="RYVGEPQ"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="31"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="170" mass="19825" checksum="7E8BCE3B0D2D555B" modified="2009-03-03" version="1">MRKSLILKFLILFIFMVFFLTTSIYPKQTQISENSPALDFTLPDIKGKQYSLSSFKGNVILLNFWATWCPPCRYEVPMLDKIQKEYKDKKFKIVAVSLDSDINALRDYLKNVNVSFLVLSDKKGSVGYAYNILAIPTSFLIDKKFVVRKIYLGILPEKEFKKDLEKWLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E311</accession>
    <name>B8E311_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583593.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353125.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1233"/>
    <dbReference type="EnsemblBacteria" id="ACK42511">
        <property type="protein sequence ID" value="ACK42511"/>
        <property type="gene ID" value="Dtur_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1233"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_2_0"/>
    <dbReference type="InParanoid" id="B8E311"/>
    <dbReference type="OMA" id="WYTTRER"/>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="252"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="597" mass="69953" checksum="03BDEEE823BDB30B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E319</accession>
    <name>B8E319_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583601.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353133.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1241"/>
    <dbReference type="EnsemblBacteria" id="ACK42519">
        <property type="protein sequence ID" value="ACK42519"/>
        <property type="gene ID" value="Dtur_1241"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1241"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1281"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_2_0"/>
    <dbReference type="InParanoid" id="B8E319"/>
    <dbReference type="OMA" id="PESYNWS"/>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="223"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="551" mass="64577" checksum="F67EE78534D1E3E2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E333</accession>
    <name>B8E333_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1634</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583982.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353521.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1634"/>
    <dbReference type="EnsemblBacteria" id="ACK42907">
        <property type="protein sequence ID" value="ACK42907"/>
        <property type="gene ID" value="Dtur_1634"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1634"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1683"/>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057297_2_0_0"/>
    <dbReference type="InParanoid" id="B8E333"/>
    <dbReference type="OMA" id="QGVHLMA"/>
    <dbReference type="OrthoDB" id="1425269at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="288" mass="32385" checksum="8962B1DB82D68F5B" modified="2009-03-03" version="1">MNFEQKLKSGKFVITAEVSPPRGVDVSSFIEKTLLLKNRIDAVNVTDFQNVGVRITSLVGSYLLLREGFEPIFQITARDRNRVAISGELLSAYALGIRNVLVLTGDYTTTGIVKSAKPVFDLDATNILVIAKKLEEGEDFSGKKLNKSPDFFLGAVFNPNLVPLEIEILKLLKKKKAGAEFFQTQLFFELSLMERVRDRVGDDVKIIAGVTIFKSLEMLEYMMDNVPGIKIPERVIEMFKNTKDIKALSIEFCVEFCSKLKESKLLDGIHFLASRPSDIIKVLDLLKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E354</accession>
    <name>B8E354_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584003.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353542.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1656"/>
    <dbReference type="EnsemblBacteria" id="ACK42928">
        <property type="protein sequence ID" value="ACK42928"/>
        <property type="gene ID" value="Dtur_1656"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1656"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1706"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174611_3_4_0"/>
    <dbReference type="InParanoid" id="B8E354"/>
    <dbReference type="OMA" id="NDKEMEF"/>
    <dbReference type="OrthoDB" id="2084255at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="62" mass="7047" checksum="7BE258073E4A5062" modified="2009-03-03" version="1">MLVNDKEVNFKGNLKELLLSLNYPTEKIVVLVNGEIVKKENWDNVELRDEDYIEIVSLVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E394</accession>
    <name>B8E394_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584043.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353582.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1696"/>
    <dbReference type="EnsemblBacteria" id="ACK42968">
        <property type="protein sequence ID" value="ACK42968"/>
        <property type="gene ID" value="Dtur_1696"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1696"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1747"/>
    <dbReference type="eggNOG" id="COG4952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060750_0_0_0"/>
    <dbReference type="InParanoid" id="B8E394"/>
    <dbReference type="OMA" id="MGQDGFD"/>
    <dbReference type="OrthoDB" id="481478at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="64"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="368" mass="42668" checksum="F59048415F8CC314" modified="2009-03-03" version="1">MPFVDHRNQKIRRSKEELLKHMQTFKLDLKFSVGIWYFTPGGGRFHEPYVEQKGIPERIEMAAEMAKYGVKGIEAHYPAEVNEENLHLYKQLEKETGIRLVAVPLSLFYDKIFEFGSLSNPYEKYRKIAYERLVNGLKLVKEANADICIIWPGIDGYTYSYGHLYYHMWDTFEELVAQAMDEVPGVQVAIEPKPYEPAPNNIYRTTADGILAARDIEARLKNPENLKLLQEGHALVGLNPEVGHVRMGFEDLPYAYARVAREGRLFHTHWNSQPLGNYDQDLNIGVVDWDSTEALLYTLKMVGYQGYFGIDINPERIPVVKAIEINTKVLQIMNERIERLPHDRIIECYFDPENHRGELELILAENHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3E2</accession>
    <name>B8E3E2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584091.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353630.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1744"/>
    <dbReference type="EnsemblBacteria" id="ACK43016">
        <property type="protein sequence ID" value="ACK43016"/>
        <property type="gene ID" value="Dtur_1744"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1744"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="InParanoid" id="B8E3E2"/>
    <dbReference type="OMA" id="YNRYDAY"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="336" mass="37205" checksum="B7F5B99CF7F24C00" modified="2009-03-03" version="1">MRREDIKKKVTLKDIAKAAGVSVSAVSFALNNKGSLNPETKTKILKIAQELGYTPERELKKTYTIGLVISDVTNPFYPAVVIGVESVLLKHGYSLFLCNTDYDPDLGCTSIKRFIDRNVDGVIIMTNRLDDSVIELLKLYNIPVLVFDRNIEGLDVSGLLVDFQSGISEAVTHLVNLGHTDIAIITGPLDLETAQARLRAFKMALKRYHIDLPEDRIFEGDFKMRSGEEAMRKILKLDPRPTAVFASNDMMAIGALREAQNQGLRIPEDISIVGLDDIMMASYVNPSLTTVVFPQQEVGTKAAELILRAIEKGEKAVSYIHTYLVIRKSTGPAPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3E6</accession>
    <name>B8E3E6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Ribulokinase</fullName>
            <ecNumber evidence="3 4">2.7.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">araB</name>
        <name evidence="7" type="ordered locus">Dtur_1748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + D-ribulose = ADP + D-ribulose 5-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17601"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17173"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>ATP + L-ribulose = ADP + H(+) + L-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:22072"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16880"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58226"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the ribulokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.16" evidence="3 4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584095.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353634.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1748"/>
    <dbReference type="EnsemblBacteria" id="ACK43020">
        <property type="protein sequence ID" value="ACK43020"/>
        <property type="gene ID" value="Dtur_1748"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1748"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1800"/>
    <dbReference type="eggNOG" id="COG1069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_9_1_0"/>
    <dbReference type="InParanoid" id="B8E3E6"/>
    <dbReference type="OMA" id="GHKAMWH"/>
    <dbReference type="OrthoDB" id="1619686at2"/>
    <dbReference type="UniPathway" id="UPA00145">
        <property type="reaction ID" value="UER00566"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008741">
        <property type="term" value="F:ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046835">
        <property type="term" value="P:carbohydrate phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07781">
        <property type="entry name" value="FGGY_RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00520">
        <property type="entry name" value="Ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005929">
        <property type="entry name" value="Ribulokinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01234">
        <property type="entry name" value="L-ribulokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0054">Arabinose catabolism</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="6">
        <location>
            <begin position="295"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK43020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="570" mass="63623" checksum="66A4664F0860AFB9" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3F3</accession>
    <name>B8E3F3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="15">DAD</shortName>
            <ecNumber evidence="14 15">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvD</name>
        <name evidence="16" type="ordered locus">Dtur_1755</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="15">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13 15">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12 15">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14 15"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584102.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353641.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1755"/>
    <dbReference type="EnsemblBacteria" id="ACK43027">
        <property type="protein sequence ID" value="ACK43027"/>
        <property type="gene ID" value="Dtur_1755"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1755"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1807"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_0"/>
    <dbReference type="InParanoid" id="B8E3F3"/>
    <dbReference type="OMA" id="TQGRNMA"/>
    <dbReference type="OrthoDB" id="193579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="470"/>
        </location>
    </feature>
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        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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            <position position="122"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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    <feature type="binding site" evidence="15">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="15">
        <location>
            <position position="122"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACK43027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="558" mass="60103" checksum="4B8552D48B6EDDC7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYI0</accession>
    <name>B8DYI0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0021</name>
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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            <taxon>Dictyoglomaceae</taxon>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="ACK41362">
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    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0021"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.21"/>
    <dbReference type="eggNOG" id="COG0579">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024775_3_1_0"/>
    <dbReference type="InParanoid" id="B8DYI0"/>
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    <dbReference type="OrthoDB" id="1371190at2"/>
    <dbReference type="Proteomes" id="UP000007719">
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="FAD-dep_OxRdtase"/>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="2">
        <location>
            <begin position="397"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACK41362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="484" mass="54604" checksum="E8A4F148AAFED7E4" modified="2009-03-03" version="1">MYDVIIIGGGIIGALIVREFSFYNLSLLLIEKESDVSMGATKANSAIVHAGYDPIPGTLKAKTNVEGNKLYQELCEELSVPFKRIGALVLAFNDEELKTLMELKDRGIKNGVPELYILKREEVLKREPNISKDVKYALFAPTSGITNPFLLTVHAIENAIGNGLVVKLNEEVVSIKKEEKFYQVITNKDIYLTKYIINCAGINSDKIIKMLDPDYPFEIIPRKGEYLVLDKKVKDFVKSTIFHVPTEKGKGVLITPTVEGNILIGPNAEEIPNKEDKSTTLNGLLEVKEKAKNYCENIPFPLVINTFAGIRASSTYKDFFIKELPEFRNILHIAGIDSPGITSAPSISKIALEWLMEKEKITPNKNAKRTLNKIFFRDLPDEEKERLIKEDPRWGHIICRCEHVSEMEVILAIHSKLPAITLEAIRKRTRAGMGRCQGAFCGYHIMKILSEELNLPLPQITFKGSGSYMVKMENKARWKYVKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYL3</accession>
    <name>B8DYL3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Na/Pi-cotransporter II-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
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            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    <dbReference type="RefSeq" id="YP_002352009.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0057"/>
    <dbReference type="EnsemblBacteria" id="ACK41395">
        <property type="protein sequence ID" value="ACK41395"/>
        <property type="gene ID" value="Dtur_0057"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0057"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.58"/>
    <dbReference type="eggNOG" id="COG1283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025623_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYL3"/>
    <dbReference type="OMA" id="FCAVAYN"/>
    <dbReference type="OrthoDB" id="1341748at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004633">
        <property type="entry name" value="NaPi_cotrn-rel/YqeW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00704">
        <property type="entry name" value="NaPi_cotrn_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="345"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="8">
        <location>
            <begin position="450"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="549" mass="60736" checksum="32B90E3910668837" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYP9</accession>
    <name>B8DYP9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582517.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352045.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0093"/>
    <dbReference type="EnsemblBacteria" id="ACK41431">
        <property type="protein sequence ID" value="ACK41431"/>
        <property type="gene ID" value="Dtur_0093"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0093"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYP9"/>
    <dbReference type="OMA" id="STWYLVP"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="356" mass="40301" checksum="00DB3CCD5C36A5FA" modified="2009-03-03" version="1">MKPFISVTLYRIKSFYRDTFTFLFSLILPIVFVLIFGFVFGEREMGSNGYGVKIGVIRSDVEIVKVLGEMENVKIFEFENEADLRNHILKGNIDGGVTFDGEKFNFIINFSTFQQNPFLRTFGESFSKAYSLHEVGMDKGFIKMEEEFIDPGKAQVSSLGYIIPGVLSFSISSAIFTMIALFGYYRKRKVIKRFAVTPINPIIFISGMVLGNFVVGIFSCLLVLLIVQLIFHINFSINWGFFLLSVSSSILGMMALGIVLTALFREPQTANNAGNLLVNIMLFFSGVYFPLDFLPSYLKVFAKFLPLYYVGRALRISLGIEEGRSSFVLTFSFVMISTFLILVFISGRNIFNLEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYQ4</accession>
    <name>B8DYQ4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582522.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352050.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41436">
        <property type="protein sequence ID" value="ACK41436"/>
        <property type="gene ID" value="Dtur_0098"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0098"/>
    <dbReference type="HOGENOM" id="CLU_1913729_0_0_0"/>
    <dbReference type="OMA" id="NIKGSIM"/>
    <dbReference type="OrthoDB" id="2121763at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="132" mass="15060" checksum="F19F0E51F3004E48" modified="2009-03-03" version="1">MRFKKFIFLLLLLLVFSLINTELIEAKPRENFNIKGSIMFIGPSGLLKVKVESHSKNIKGFVRNDVVSIKITSGTKFYFASFVKTNEGLELKKHKSVGFGFLKIKSKVFINGFILENNKKELVATEIYIILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYT6</accession>
    <name>B8DYT6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582553.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352082.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0136"/>
    <dbReference type="EnsemblBacteria" id="ACK41468">
        <property type="protein sequence ID" value="ACK41468"/>
        <property type="gene ID" value="Dtur_0136"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0136"/>
    <dbReference type="HOGENOM" id="CLU_2129458_0_0_0"/>
    <dbReference type="OMA" id="FCWLARD"/>
    <dbReference type="OrthoDB" id="2136366at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="113" mass="12997" checksum="5E3086E4BDF9CEEE" modified="2009-03-03" version="1">MIYSDFYGKYLDIAFYGVLIGLIFFFIYSPISSLIFGLSGSIISFCWLARDLKKYGLSGYNRSIIKRYGVLILLFLLSVKAGFIGVILFLIGYVVGQWYMIWKVWRSKDGTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYU1</accession>
    <name>B8DYU1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0029 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582558.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352087.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0142"/>
    <dbReference type="EnsemblBacteria" id="ACK41473">
        <property type="protein sequence ID" value="ACK41473"/>
        <property type="gene ID" value="Dtur_0142"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0142"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.148"/>
    <dbReference type="eggNOG" id="COG1739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083552_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYU1"/>
    <dbReference type="OMA" id="VTVDHQR"/>
    <dbReference type="OrthoDB" id="1777855at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020569">
        <property type="entry name" value="UPF0029_Impact_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="PTHR16301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00910">
        <property type="entry name" value="UPF0029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0029" evidence="2">
        <location>
            <begin position="21"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="196" mass="23067" checksum="9AC2B2F15BF65D30" modified="2009-03-03" version="1">MIREKYLTVEKEEIFEIKIERSLFIGIVSPINNRHPSDILKEVKERYKNATHYCYAYRKATGEEYFTDGGEPTGTAGIPILNALRERDLYDIIGIVIRYFGGIKLGIRGLIDAYHYTMEKTLEKAKITEKIITSDYVVRLSYKDFNAFKSEILRHFKCEVKEKFEDNVIMEIKVPIFLKDDFEKFLFKRGVEIEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYU5</accession>
    <name>B8DYU5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="6 7">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582562.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352091.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0146"/>
    <dbReference type="EnsemblBacteria" id="ACK41477">
        <property type="protein sequence ID" value="ACK41477"/>
        <property type="gene ID" value="Dtur_0146"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:alkane catabolic process"/>
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        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="52" mass="5742" checksum="5F26876AE094EDE6" modified="2009-03-03" version="1">MGKYRCVVCGYVYDPEEGDPEGNIPPGTSFEELPEDWVCPVCGADKSMFKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYV9</accession>
    <name>B8DYV9_DICTD</name>
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        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0160"/>
    <dbReference type="EnsemblBacteria" id="ACK41491">
        <property type="protein sequence ID" value="ACK41491"/>
        <property type="gene ID" value="Dtur_0160"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_0"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF161098"/>
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    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="74"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="292" mass="32987" checksum="A01174A7A6C3EEC2" modified="2009-03-03" version="1">MFLVIKDLYKSDKKFAFGFTVLMILIFLALISFLSPYDPKLWNVAPKNLPPSFKYILGTNSMGQDIFWNLTHAIKNSLFLGSLTAVISIFVGTLVGLVAGYLGGRTDRILMSINDSFIVIPSLPILILISSIIKQHISIVLIAVILSLFSWPWGGRQVRSIVLGLREREFTYTANFSGMDTLKIVLTEHLPFVIPWVMANFINTILWAIGMETTLAIYGLSSLETPTIGTTIYWALQYQALLRGIWWWIFTPVLIAILLFIALYLLSVSISNYLDPRTRLQRMRMKEGGLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ10</accession>
    <name>B8DZ10_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-L-fucosidase</fullName>
            <ecNumber evidence="6">3.2.1.51</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352250.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0315"/>
    <dbReference type="CAZy" id="GH29">
        <property type="family name" value="Glycoside Hydrolase Family 29"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41636">
        <property type="protein sequence ID" value="ACK41636"/>
        <property type="gene ID" value="Dtur_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0315"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.334"/>
    <dbReference type="eggNOG" id="COG3669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002934_6_1_0"/>
    <dbReference type="InParanoid" id="B8DZ10"/>
    <dbReference type="OMA" id="WESTDKH"/>
    <dbReference type="OrthoDB" id="439010at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016286">
        <property type="entry name" value="FUC_metazoa-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031919">
        <property type="entry name" value="Fucosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="PTHR10030"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16757">
        <property type="entry name" value="Fucosidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001092">
        <property type="entry name" value="Alpha-L-fucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00741">
        <property type="entry name" value="GLHYDRLASE29"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fucosidase_C" evidence="5">
        <location>
            <begin position="383"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="464" mass="54675" checksum="BF8531DBB4DEA321" modified="2009-03-03" version="1">MPEGPFRPTWESLKNYKIPEWYKDAKFGIFIHYGVYSVPAFSNEWYPRNMYIEGTPEYEHHIKTYGEHKRFGYKDFIHLFKAERFDPYEWADLFKKAGAKYVVPVAEHHDGFAMYDCSFTRWCASKMGPKRDIIGELAKAVRENFLTFGISYHRAEHWWFFHEGMKFDSDVRDKDYFDLYGPAQPEPMQPTEEFLEDWLLRLLEIVDKYQPQVVYFDWWIEQPAFEPYLKKFFAYYYNRAHEWGKGVVINYKLNAVPRECAVFDVERGELGDIDPIYWQTDTSISRISWGYVENDIYKPAKELIWELVDIVSKNGNLLLNVGPKADGTIPEAAQKTLLEIGEWLLKNGEAIYGTRPWRIYGEGPTKGNAGSFSEKEINYTGRDLRFTTKGDTLYAILMNKPEKDEIVIKSLSTELTLYQKEVAKVELLGLKGELKFERNEEGLKIKIPEFEKLNYPITFKIWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ20</accession>
    <name>B8DZ20_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582731.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352260.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0329"/>
    <dbReference type="EnsemblBacteria" id="ACK41646">
        <property type="protein sequence ID" value="ACK41646"/>
        <property type="gene ID" value="Dtur_0329"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0329"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.350"/>
    <dbReference type="eggNOG" id="COG2407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055583_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ20"/>
    <dbReference type="OMA" id="WTPCISL"/>
    <dbReference type="OrthoDB" id="507566at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009015">
        <property type="entry name" value="Fucose_isomerase_N/cen_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53743">
        <property type="entry name" value="SSF53743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="371" mass="41975" checksum="2346308B841C6D38" modified="2009-03-03" version="1">MKVKFLLSPIAYKVDEKLKEAKEYLGRYLNLEESEDPDAIILLTGGTEEEALKYLKDGLFIIPFGIANGLAASLEVQAYAKEKGIKTILITKPDENIMNVLRVMDELKNKKVGIIGKPSDWLIKSGNYDVLKELGLEPVEISLKEVEENLKEDPTLSDKIWELSKDKKISKEELLKATKVYTSLKKIIDKYNLYAITVRCFDLAINLKITGCLALSLLNAEGIIASCEGDTEALATMLFAYKLTNKTPFMANLARIENNEYTFAHCTIAINIPEYFNLNTHFETLSSVGIEGYINSEKITILRIGRNKKFTLFTGEVVKKPFEENMCRTQITAKIKDDSFLQNPIGNHFIILLGDEEEKIKSLEKIGWERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ30</accession>
    <name>B8DZ30_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582741.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352270.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0342"/>
    <dbReference type="EnsemblBacteria" id="ACK41656">
        <property type="protein sequence ID" value="ACK41656"/>
        <property type="gene ID" value="Dtur_0342"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0342"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.362"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040286_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZ30"/>
    <dbReference type="OMA" id="FYIIKSH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004112">
        <property type="term" value="F:cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009214">
        <property type="term" value="P:cyclic nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="196"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="389" mass="45434" checksum="694CE5535D379066" modified="2009-03-03" version="1">MSLLAFLLAFSEQLDSQLPENRRHSSRVANISLAIANHLKLPEKSKYELVISALLHDAGNGNKNNNYNHKEISDHALKSSLFLSDIPFLERPATIIKYHHFSWNLGRGEFYQDEKIPIESQILNLAEHIDENYDKSKYILKEKNKIIKKIKEKGENLFHPDVLNAFYDLSQKESFWFEINYDNITPKDFYCDIKLDIDSFLLLSKAIARIVDYRSRIQVRHSRNVANISSFLAGNLNINDEKIKRIRISGYLHDIGKVALSSKILLKKDKLTRKETEYIKVHPFKTFLTLKNSIPFEDIIIWSSYHHEKLNGKGYPFRLKGNEIPIEARIVATADIYSALLEDRPYRKGVSEKMAINYMRRLAREGYIDKDIFEVLYENREELKSVIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ43</accession>
    <name>B8DZ43_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582754.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352283.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0358"/>
    <dbReference type="EnsemblBacteria" id="ACK41669">
        <property type="protein sequence ID" value="ACK41669"/>
        <property type="gene ID" value="Dtur_0358"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0358"/>
    <dbReference type="HOGENOM" id="CLU_1382193_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867695" evidence="1">
        <location>
            <begin position="24"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="197" mass="22433" checksum="42EEB7B6448EA7AB" modified="2009-03-03" version="1">MKKTLIFSLISLMFLFISGCIPKTNPPTQGNTPVFVDHFENETNNENTYTSTFYGETIDSIRNISFVNGKVGKGVHLDALNSYICYSTQYLNPTEGTIKFYFKPNSDYQLTYYDSTTMNNRFEAFLLDTVGWLEAFSGGFSNVMLFGVDQNTQEKIINMIFGTWSGYSWSYAIAESITLPTDQFTEIAVIWNKSSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ54</accession>
    <name>B8DZ54_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582765.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352294.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0376"/>
    <dbReference type="EnsemblBacteria" id="ACK41680">
        <property type="protein sequence ID" value="ACK41680"/>
        <property type="gene ID" value="Dtur_0376"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0376"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZ54"/>
    <dbReference type="OMA" id="QAVIVPM"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="278" mass="32158" checksum="592E44863692C452" modified="2009-03-03" version="1">MNKTKLEGINNLILILILFGIGVLMLLPFIWMFFTSLKDWGEIFKFPPTLFPSKLRWENYKELFQIAPVIAWLKNSLFLSIVSTIGVLLSSSIVAFAFAMMNFKGKGFWFSILLLTMMVPFHVTMIPQYILFRYLGWINTLKPLWVPTFTGAPYMIFLLRQFYRSVPKSYFESARIDGASFWQIFYRIYVPLSLPVTVTVALLTFINQWNYFLGPLIYLNDINKMTITAGLSFLQGQSFGYWNYIMAGSTIAVLPILLLFLLTQKYIIEGIMLQAGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ74</accession>
    <name>B8DZ74_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sulfur relay protein TusB/DsrH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582892.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352421.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0514"/>
    <dbReference type="EnsemblBacteria" id="ACK41807">
        <property type="protein sequence ID" value="ACK41807"/>
        <property type="gene ID" value="Dtur_0514"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0514"/>
    <dbReference type="eggNOG" id="COG2168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166087_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZ74"/>
    <dbReference type="OMA" id="DTILFVQ"/>
    <dbReference type="OrthoDB" id="1995110at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990228">
        <property type="term" value="C:sulfurtransferase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007215">
        <property type="entry name" value="Sulphur_relay_TusB/DsrH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37526">
        <property type="entry name" value="PTHR37526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04077">
        <property type="entry name" value="DsrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03011">
        <property type="entry name" value="sulf_tusB_dsrH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="92" mass="10426" checksum="38A948BD4860B9F7" modified="2009-03-03" version="1">MALIIIKKSPREEISKRIIELAVEGDTILFVQDGVLYAIDETTKEFIKSGVSVFALKEDLEARGYSESLSLFPCIDYEGWVELIEKNEKIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ88</accession>
    <name>B8DZ88_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582906.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352435.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0529"/>
    <dbReference type="EnsemblBacteria" id="ACK41821">
        <property type="protein sequence ID" value="ACK41821"/>
        <property type="gene ID" value="Dtur_0529"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0529"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_5_1_0"/>
    <dbReference type="InParanoid" id="B8DZ88"/>
    <dbReference type="OMA" id="KELHGYE"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="26"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="127" mass="14640" checksum="7C527537984DF4BC" modified="2009-03-03" version="1">MKGFGRGLGMGKGMGFAPGFWLRAFVLFALSKKELHGYELLNMMEKYFPEFSFYKGPSGMGTGYRILRMLEMEGLIGSRWETGEGPAKRVYFLTPLGERVKNEIIEYIKDMRDRIEKFLEFAEGKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZA6</accession>
    <name>B8DZA6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582924.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352453.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0549"/>
    <dbReference type="EnsemblBacteria" id="ACK41839">
        <property type="protein sequence ID" value="ACK41839"/>
        <property type="gene ID" value="Dtur_0549"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0549"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.585"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZA6"/>
    <dbReference type="OMA" id="CSFPFVM"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="75"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="297" mass="34035" checksum="8AE36AE5F59D55BA" modified="2009-03-03" version="1">MIKPKNIRNLRTYIIFAGIPTLAFLTVVILPFIYGVYLTFTDFNAVETVNQFLSKFVGLSNYVKAISDSAFRESFLKTFKYVFYTMVFTNLIAFFLAYILTSGIKGQNFFRVAFFTPNLIGGIILGFIWQFIFNSAFPYIGYKLNIPLFYDSWLATPQKAFWALVTVTVWQYVGYMMMIYIAGFVSIPQDLLEAATIDGAGKWHKLVRIILPLMVPSFTVTIFLTLQRSFMVYDLNLALTRGGPFKSTELVSMHVYNEAFLYQRYAIGQAKALILFITVALITMIQVYFSKKAEVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZB0</accession>
    <name>B8DZB0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase U62 modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582928.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352457.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0553"/>
    <dbReference type="EnsemblBacteria" id="ACK41843">
        <property type="protein sequence ID" value="ACK41843"/>
        <property type="gene ID" value="Dtur_0553"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0553"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_2_0"/>
    <dbReference type="InParanoid" id="B8DZB0"/>
    <dbReference type="OMA" id="DTMVAGN"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="209"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="437" mass="48714" checksum="3CEA737D60D25CA5" modified="2009-03-03" version="1">MLEKLVEIGKKYADEVEIYQVNNFSSGVSFENGVLKDVETSIQSGISLRIIKDGKLGFSYTKNLLDPEGFVKNAIDSLKGDIKVEFSFPIGKELKTLNTYDLEIENLTNTKMVEEGQRISDILSQATNTQVNVGLVKSVSEIRIINSNGVDYSTKNSFYMCYAAAMYPGSYSSITRVVADKKFKEFSKEDFDYITFLYNSSRKEVKPKSGKMKVMFLPNTMYVLIWRLVYGTNGKNVYEKTTPLIDKIGSQIFDPAISIYNDPFDDTIPGSRAFDDEGVESKILPIVENGVLKNFYYDLYYGSKMGVGSTGNGYKVSDWGGEIIRVRPTPSLEHLHMKPGDKDFYEMIKSMDKGIIVAQALGAHSGNIPNGDFSIGLSPGLYVENGEILGHVKDAMVAGNIYEVMRNVLSLENKTYMANMGVFPSAIFEDVSVAIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZB5</accession>
    <name>B8DZB5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase (Ubiquinone) 24 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582933.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352462.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0558"/>
    <dbReference type="EnsemblBacteria" id="ACK41848">
        <property type="protein sequence ID" value="ACK41848"/>
        <property type="gene ID" value="Dtur_0558"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0558"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.594"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_0"/>
    <dbReference type="InParanoid" id="B8DZB5"/>
    <dbReference type="OMA" id="MYDTKPV"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0830">Ubiquinone</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="161" mass="18083" checksum="A5E50DFAD1F22FEF" modified="2009-03-03" version="1">MKLKRNFTKVEEILKKHEYRKDNLIKILLDIQKEYRYIPEDVINYIGVALDIPPAKIYGVATFYAQFSLKPKGKYTILVCDGTACHMAGSTSLIGAIKEELNIGPGEVTEDLMFSLDQVGCLGACALAPVMVINEEVYGNLTPEKVKEILKNLKEREMKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZB7</accession>
    <name>B8DZB7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hydrogenase, Fe-only</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582935.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352464.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0560"/>
    <dbReference type="EnsemblBacteria" id="ACK41850">
        <property type="protein sequence ID" value="ACK41850"/>
        <property type="gene ID" value="Dtur_0560"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0560"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.596"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018240_2_1_0"/>
    <dbReference type="InParanoid" id="B8DZB7"/>
    <dbReference type="OMA" id="CGDCVRM"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003149">
        <property type="entry name" value="Fe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036991">
        <property type="entry name" value="Fe_hydrogenase_ssu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013352">
        <property type="entry name" value="Fe_hydrogenase_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02256">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00902">
        <property type="entry name" value="Fe_hyd_SSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02512">
        <property type="entry name" value="FeFe_hydrog_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="8">
        <location>
            <begin position="77"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="666" mass="74364" checksum="0E94DA5CC0B41A6A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZF1</accession>
    <name>B8DZF1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582969.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352498.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0596"/>
    <dbReference type="EnsemblBacteria" id="ACK41884">
        <property type="protein sequence ID" value="ACK41884"/>
        <property type="gene ID" value="Dtur_0596"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0596"/>
    <dbReference type="HOGENOM" id="CLU_2842723_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="65" mass="7849" checksum="FEDA5CE0D5D2D599" modified="2009-03-03" version="1">MYIKSRIERIYREITELKKILILEGVIDKEKSEVAWRNLLILSKEISARWEGFSAVEEIRNQREK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZH0</accession>
    <name>GCH4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP cyclohydrolase FolE2</fullName>
            <ecNumber evidence="1">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">folE2</name>
        <name type="ordered locus">Dtur_0615</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts GTP to 7,8-dihydroneopterin triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase IV family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582988.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352517.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZH0"/>
    <dbReference type="SMR" id="B8DZH0"/>
    <dbReference type="STRING" id="515635.Dtur_0615"/>
    <dbReference type="EnsemblBacteria" id="ACK41903">
        <property type="protein sequence ID" value="ACK41903"/>
        <property type="gene ID" value="Dtur_0615"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0615"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.652"/>
    <dbReference type="eggNOG" id="COG1469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062816_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZH0"/>
    <dbReference type="OMA" id="PCSQGMS"/>
    <dbReference type="OrthoDB" id="757842at2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003933">
        <property type="term" value="F:GTP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01527_B">
        <property type="entry name" value="GTP_cyclohydrol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022838">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00294">
        <property type="entry name" value="TIGR00294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000215389" description="GTP cyclohydrolase FolE2">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="site" description="May be catalytically important" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01527"/>
        </source>
    </evidence>
    <sequence length="257" mass="29786" checksum="F662CF9D0E55F2BF" modified="2009-03-03" version="1">MKDVQNERDYRGIYLRKVGIKNIHWPIKIITKSGEYQSTVANIDISVDLREDLRGTHMSRFVEVLNGIDFLHPENLGKILQEVREKLKADSSHIKITFPYFIFKKTPVSQIASPNMIECVIEAELSKKLYMIIGVKVPIHTLCPCSKEISEYGAHNQRAIAEIYIKSKKLIWFEDLVEIAERSASAPIYSLLKRPDEKYITETAYNNPKFVEDVVRDIVSELEKEPKISWYRVEVTSFESIHNHNAFACVEKGWIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZJ0</accession>
    <name>B8DZJ0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583008.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352537.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0638"/>
    <dbReference type="EnsemblBacteria" id="ACK41923">
        <property type="protein sequence ID" value="ACK41923"/>
        <property type="gene ID" value="Dtur_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0638"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.676"/>
    <dbReference type="eggNOG" id="COG1163">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044997_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZJ0"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="1065996at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="PTHR43127"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="2">
        <location>
            <begin position="253"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="328" mass="37494" checksum="D84DFDD93C7E9C07" modified="2009-03-03" version="1">MPANLPPQYFEAEKKFREAKTIEDKIQALKEMLAILPKHKGTDKMKADLRRKLSQLMEEAEKRAKKGGGRGLDYIEKEGAGQVLLIGPPNTGKSKFFTLLTGVESLVADYPFTTMNPVIGMLPYENIQIQLVDLPPLWEESEGWMYNLIRNADLIILFLSMDLDSIVDEYIKIRNLLEGKKIKLVRKNPDRDPYSPIKENRGIVILNKIDIFAPEERKEEIEIIKKDLNVFCVSAEEGVNMEDIKKSIFDALHIVRVYTKKPGYPPDLSKPYILEKGSTVLDVAEMIHKDIAKNLKFAKLYKKDGSVKGLPVEKSYEVKDEDILEFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZN3</accession>
    <name>B8DZN3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cellulase</fullName>
            <ecNumber evidence="10">3.2.1.4</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0681</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583051.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352580.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0681"/>
    <dbReference type="EnsemblBacteria" id="ACK41966">
        <property type="protein sequence ID" value="ACK41966"/>
        <property type="gene ID" value="Dtur_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0681"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_0_2_0"/>
    <dbReference type="InParanoid" id="B8DZN3"/>
    <dbReference type="OMA" id="FMAHMDE"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="332" mass="36546" checksum="EA96C9CABCF38797" modified="2009-03-03" version="1">MFLKELSDIPGVSGFEGKVREFIKEKIKDKVDYIETDKLGNLIALKKGKVNKKLMITAHMDEVGFIVSNIEEDGKISIIPLGTIDPRVVLGKKVVIGEKQILGVIGSKPVHLMEGYEKVSFENIKVDIGATKKQEAESKVKIGDFVSFAPNAMVHEEWISGKALDDRGGCSILMDLILSGLDLYYDTFFAFVIQEETGLRGSGSCAFKINPDFAIVVETTTSGDNPEFPPDRRSSELGKGPVITPAHRGYVNDERLFNFAVKVAKENNIPYQIKRRTVGGTDAARIAITTGTPSLVISIPSRYIHSPMSVVNISDYQNTLKLLSLILIKEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZS4</accession>
    <name>B8DZS4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583092.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352621.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0723"/>
    <dbReference type="EnsemblBacteria" id="ACK42007">
        <property type="protein sequence ID" value="ACK42007"/>
        <property type="gene ID" value="Dtur_0723"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0723"/>
    <dbReference type="HOGENOM" id="CLU_1522827_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="176" mass="20587" checksum="0BB2904DB917C6C6" modified="2009-03-03" version="1">MAVLLKISGIILKTKNKIYTSSWLNSSEEKIIKDGGFKVSREMKLISFYKMSIIKGISLRVFQLLLGRFEFINKLVKKFLRGILITKQKSSGIRFFRTIKVVNEKIEMEDLILSSENINKVFCVVENSYIFIPSSRYFEIGDLNKYFHEIEVGSKKVIIRRVFDEEGNEEFDYKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZV2</accession>
    <name>B8DZV2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_0753</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583120.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352649.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0753"/>
    <dbReference type="EnsemblBacteria" id="ACK42035">
        <property type="protein sequence ID" value="ACK42035"/>
        <property type="gene ID" value="Dtur_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0753"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.791"/>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_3_0_0"/>
    <dbReference type="InParanoid" id="B8DZV2"/>
    <dbReference type="OMA" id="HCVQWLI"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034628">
        <property type="term" value="P:'de novo' NAD biosynthetic process from aspartate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="19"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="435"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="542" mass="61701" checksum="62C0BC85F263E4AA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZX9</accession>
    <name>B8DZX9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583147.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352676.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0781"/>
    <dbReference type="EnsemblBacteria" id="ACK42062">
        <property type="protein sequence ID" value="ACK42062"/>
        <property type="gene ID" value="Dtur_0781"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0781"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.820"/>
    <dbReference type="eggNOG" id="COG1480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015767_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZX9"/>
    <dbReference type="OMA" id="DFIRTHH"/>
    <dbReference type="OrthoDB" id="1124669at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="457"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="667" mass="77223" checksum="7EE16983ADDAD772" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZZ5</accession>
    <name>B8DZZ5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="4">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ispG</name>
        <name evidence="5" type="ordered locus">Dtur_0797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583163.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352692.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0797"/>
    <dbReference type="EnsemblBacteria" id="ACK42078">
        <property type="protein sequence ID" value="ACK42078"/>
        <property type="gene ID" value="Dtur_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0797"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.835"/>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042258_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZZ5"/>
    <dbReference type="OMA" id="PTCGRTQ"/>
    <dbReference type="OrthoDB" id="665306at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="355" mass="38958" checksum="E856634258A46FC3" modified="2009-03-03" version="1">MKRKITRVVKVGNIEIGGNNPIRVQTMTKTPTVDVKATVRQIRRLAKKGCEIVRVGVPDKESALALGKIKKESPIPIVADIHFDYRLALTALEQGVDKLRLNPGNIKNPKYVSIIAKEAKARGVPIRVGSNAGSLPKEILEKYGGLTSEALVESALNEVRLLEDNDFTDIVISVKASSVPLTVEAYRLLSEKVDYPLHIGITEAGTLFPGTIRSSVGLGILLYEGIGDTIRVSLSAPPDKEVEVAYEILDSLELRRKGLRVLACPMCARSHFPVQEVAKEIEKRFGDYPLNLVIAVMGCEVNGPGEAKWADIGITGSKERVIIFKKGKIIKETSFERIISELEEELTKIKEVNSN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-12-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E004</accession>
    <name>PRMC_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="1">RF MTase</shortName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmC</name>
        <name type="ordered locus">Dtur_0806</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583171.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352701.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E004"/>
    <dbReference type="SMR" id="B8E004"/>
    <dbReference type="STRING" id="515635.Dtur_0806"/>
    <dbReference type="EnsemblBacteria" id="ACK42087">
        <property type="protein sequence ID" value="ACK42087"/>
        <property type="gene ID" value="Dtur_0806"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0806"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.844"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_3_1_0"/>
    <dbReference type="InParanoid" id="B8E004"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000414519" description="Release factor glutamine methyltransferase">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <sequence length="282" mass="33188" checksum="78BF4857A72D492D" modified="2009-03-03" version="1">MAQPLREVLVWLNNKIKEINPESAWLEAELLVAFVLNKDRAFIYTIDFLTDEEVEKLKKLLDLRKKGIPLNYIIEKKQFYDIELFVERGVLIPRSETEILIEVAKDTILKEGYKKIVEIGVGSGNISITLAKEFKDIKIYACDISPEAIKVARFNAKKHKVSDKIEFFFGFLLYPMVHRNVDFELIISNPPYIASWEFPFLQKEVKKEPWKALYGGWDGCEFYRKLFTLLKKRGKNFTAILEISPYIYHKVLNILKNFFDSVIIESFRDYLGHERVIKVIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E006</accession>
    <name>B8E006_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0808</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583173.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352703.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0808"/>
    <dbReference type="EnsemblBacteria" id="ACK42089">
        <property type="protein sequence ID" value="ACK42089"/>
        <property type="gene ID" value="Dtur_0808"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0808"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.846"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_1_2_0"/>
    <dbReference type="InParanoid" id="B8E006"/>
    <dbReference type="OMA" id="AFFPQKA"/>
    <dbReference type="OrthoDB" id="2062716at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="147" mass="17182" checksum="ED4B22D451B6CD7A" modified="2009-03-03" version="1">MKIVFVCTGNTCRSPMAEYLFKDIMEKMNVYNIEVTSAGIFAFEGREPSQFSVKVMLEKGIDISSHRSKRLTIDLVKEASIVYTMTKDQLFILKEMYPNFKNKILTLGEEDIEDPFGLDIEKYREVRDKIEKEIIKIIENLKERVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E013</accession>
    <name>B8E013_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Surface antigen (D15)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0815</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583180.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352710.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0815"/>
    <dbReference type="EnsemblBacteria" id="ACK42096">
        <property type="protein sequence ID" value="ACK42096"/>
        <property type="gene ID" value="Dtur_0815"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0815"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007664_1_1_0"/>
    <dbReference type="InParanoid" id="B8E013"/>
    <dbReference type="OMA" id="IFMPAFG"/>
    <dbReference type="OrthoDB" id="258122at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="402"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="5">
        <location>
            <begin position="474"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="961" mass="109088" checksum="931ADB340E41913E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8E017</accession>
    <name>B8E017_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lpxD</name>
        <name evidence="7" type="ordered locus">Dtur_0819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583184.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352714.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0819"/>
    <dbReference type="EnsemblBacteria" id="ACK42100">
        <property type="protein sequence ID" value="ACK42100"/>
        <property type="gene ID" value="Dtur_0819"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0819"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.858"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049865_0_0_0"/>
    <dbReference type="InParanoid" id="B8E017"/>
    <dbReference type="OMA" id="QIQIAHN"/>
    <dbReference type="OrthoDB" id="1602061at2"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LpxD" evidence="6">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="35724" checksum="0642E8F38E10B45D" modified="2009-03-03" version="1">MLLSEIAKIIEGELIGEDMDIEKVAEWEIATEKDLIFVFNSKDIDKIEGKTKARSLVIPLDGKSNKTHIKVENPRLAMAKLLKFFDFRIYPSGVHDTAILGKNVELGEDIGIGAYVVVGNNVKIGKGTKIFPGVVIGNNIEIGENCIIYPRVTIYDHVIVGNNVIIHSGCSIGVDGFGYVWNGKEHFKITHIGKVVIEDNVEIGGNTVIERATLGETKIGKGTKIGSLIMIGHNVKIGENCVIVSQSGIAGSSELGNNVVMAGQSGVSDHVRVGNNVVILAKSGVTKDIPDNMVVSGFPARPHREEMKIQAILKKLPDLWEEIKKLKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E036</accession>
    <name>B8E036_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Efflux transporter, RND family, MFP subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583203.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352733.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0838"/>
    <dbReference type="EnsemblBacteria" id="ACK42119">
        <property type="protein sequence ID" value="ACK42119"/>
        <property type="gene ID" value="Dtur_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0838"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_2_0"/>
    <dbReference type="InParanoid" id="B8E036"/>
    <dbReference type="OMA" id="TGKIQPE"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="4">
        <location>
            <begin position="15"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="5">
        <location>
            <begin position="50"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="100"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="432" mass="48544" checksum="5EED29F1497E667F" modified="2009-03-03" version="1">MKKRLIIIFIIVILIGIGVWWGFGRSKNNEKNSSILNTYTVRRGDLLVTVSGSGTLEAERSLDITSKVSGTVIYVVEEGTRVKEGDILVKIDPTDYQNTYQQALITYKNYENSYEQARLNYDTQKRQLEKNLKDAQISRDNAYIEYQNAKNNLERTEELFKKGFASQSDLDTARFNFEKAKNSITQAENNLKLIKENYDTQLKTLQRDLEASKLSLEKAKIDLSNAKRNLDNTIIRAPFSGIVANVNVVKGQNISSNVTLMTLLDTKNVELSLEVDETDIGKVFVGLPVRISLDAFPDEEFEGKVIRISPTATISNNIPIFKVRVRVPNKDFRLKVGMSADGDIILLERKNVLLVPLKAVQKTERRSYVEVLKPNGSRELVRITLGEDDGTNVVVESGLKEGDVVIVPSSSTSSNTSRNQQLQIRIPGVPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E062</accession>
    <name>B8E062_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Geranylgeranyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583229.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352759.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0864"/>
    <dbReference type="EnsemblBacteria" id="ACK42145">
        <property type="protein sequence ID" value="ACK42145"/>
        <property type="gene ID" value="Dtur_0864"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0864"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.902"/>
    <dbReference type="eggNOG" id="COG0644">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024648_0_1_0"/>
    <dbReference type="InParanoid" id="B8E062"/>
    <dbReference type="OMA" id="GMCRREV"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="396" mass="44953" checksum="A11845A79E837F0B" modified="2009-03-03" version="1">MIWDLVIIGGGPVGSFAGYLAGNHNLKTLIVEEHNKIGEPLHCLGKLSVHAFEEFPLPHEPIRSNLKGGYFFFPNGNFIKLKKANPDSYILDRSLFDIMLAKMAEKNGCTFLMSAKAIGIEKENNKTKLIVEEKGKRKEIETRVIINAEGAKRQFAKKLGLRINPYLVSLQYEVTGLELLDNECVEVYLGLEYSKGFFLWISPYGDMAKIGVAVKPSENPKIYLDKFINTLKKTRNLKPEILRTYGGIIPILGPYEEYLYPNIIIIGDAAGYNKSTTGGGIYFGLYGAQIAIEQVKKYLKDSNINHLKVFPKLTYKKFGKELKFTKIARKFLDQLSDENLNEIYKIINSEEIIRTIENFGDTAYQTSILKIVPKLLKNKDFYRVLKLTPKLLDSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8E090</accession>
    <name>B8E090_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353149.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42535">
        <property type="protein sequence ID" value="ACK42535"/>
        <property type="gene ID" value="Dtur_1257"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1257"/>
    <dbReference type="HOGENOM" id="CLU_2023047_0_0_0"/>
    <dbReference type="OMA" id="KIMYCEC"/>
    <dbReference type="OrthoDB" id="1720318at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="122" mass="14012" checksum="822833F2272F330D" modified="2009-03-03" version="1">MEAILLIVGALLILYLGDKLIKYFTTPKCPKCGKILLTRYRLLKAPTPFEDGVEEKIMYCECGYEKRVTYNVPYWKIIRKEGLRGFEVVPWTKLYEEEEVDQATAELRDSEESPNTKGQGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E092</accession>
    <name>B8E092_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="15" type="ordered locus">Dtur_1259</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583619.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353151.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1259"/>
    <dbReference type="EnsemblBacteria" id="ACK42537">
        <property type="protein sequence ID" value="ACK42537"/>
        <property type="gene ID" value="Dtur_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1259"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1299"/>
    <dbReference type="eggNOG" id="COG1350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042858_1_0_0"/>
    <dbReference type="InParanoid" id="B8E092"/>
    <dbReference type="OMA" id="MLHQTII"/>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052684">
        <property type="term" value="F:L-serine hydro-lyase (adding indole, L-tryptophan-forming) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006316">
        <property type="entry name" value="Trp_synth_b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF6">
        <property type="entry name" value="PTHR48077:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500824">
        <property type="entry name" value="TrpB_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01415">
        <property type="entry name" value="trpB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="14">
        <location>
            <begin position="77"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACK42537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="450" mass="50280" checksum="225C116A1A4B497D" modified="2009-03-03" version="1">MSKVKFILDESKIPKDWYNIIPDLPFPLPPVYHPVTLQPVKPEDLAPIFPVELIKQEVSTERYIEIPEEVRKIYKLWRPTPLYRALNLEKYLDTPAHIYYKYEGVSPPGSHKPNTAVAQAFYNKLEGVKRLTTETGAGQWGSALAMACNFFGLECKVYMVKVSYYQKPYRRSLMEIWGAKVVPSPSPDTESGRRILEQDPDSPGSLGVAISEAVEDAVKRDDTKYSLGSVLNHVLLHQTVIGEEALLQMEIAGEFPDVVIGCVGGGSNFAGISFPFIREKFKGKKIRIIAVEPESCPSLTKGVYTYDYGDVAKMTPLLKMYTLGHNFIPPAIHAGGLRYHGMAPLVSALYHHGYIEAVAYPQTKVFEAGVIFAKTEGIVPAPESTHAIRAVIDEALDAKEKGEKKVILFNLSGHGFFDLSAYDQYLSGKLEDYFYPKDKVEEALKELPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0B5</accession>
    <name>B8E0B5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583642.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353174.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1282"/>
    <dbReference type="EnsemblBacteria" id="ACK42560">
        <property type="protein sequence ID" value="ACK42560"/>
        <property type="gene ID" value="Dtur_1282"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1282"/>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047797_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0B5"/>
    <dbReference type="OMA" id="AFEVCGY"/>
    <dbReference type="OrthoDB" id="1806125at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="37"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="375" mass="41606" checksum="7E8DCEEF0C71FED7" modified="2009-03-03" version="1">MNKVAITRTKDDIYKSVGDAIDLIGGIEKYVKRGDIVLIKPNAFISKEEKGFISDSQVVLSLAKLCKEQGAKEVYIGERTPTVFKWYKKEEINFAKVICFDDPPHNLKTLPEAEVIKSAVPIPPIVEECDVFINVPGLRFHALTIISNGMKNIMGIMPKETTLLIHVSGLEDAIVDLNRFRKSDLVITTAINTLVGNFPVGGYGIESNTLIVGDNVVAVDSIAARVLKVDPYKIRHLTLAKKFSLGPIDLSEIELLGVPIESLEWREKIVEPTLEYEEFRDKINIIDPSKSCPSCKRAMASGIAGIFEEDPNADLKDITVVIGPVEDLNKYKLTKKLILFGNCTFPYKDQGLYVQGCPPRANMAKQAIKKIMEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0C3</accession>
    <name>B8E0C3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583650.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353182.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42568">
        <property type="protein sequence ID" value="ACK42568"/>
        <property type="gene ID" value="Dtur_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1290"/>
    <dbReference type="HOGENOM" id="CLU_2751318_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="70" mass="8851" checksum="4EEF2667ABBF1FB9" modified="2009-03-03" version="1">MEVKIKDLIELLDLEREYEEFKKVMDTAVERFISCGYDEDFLIYRLKKYFEKEKRIILMIFLERYREEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0K4</accession>
    <name>B8E0K4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="9" type="ordered locus">Dtur_1375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583728.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353263.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1375"/>
    <dbReference type="EnsemblBacteria" id="ACK42649">
        <property type="protein sequence ID" value="ACK42649"/>
        <property type="gene ID" value="Dtur_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1375"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1420"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_1_0"/>
    <dbReference type="InParanoid" id="B8E0K4"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="176" mass="20428" checksum="BFCC6896D3AC97A0" modified="2009-03-03" version="1">MAEPKWFVVHTLAGHEHKVKAILERQVKLNHLEDKVFEIVVPEEKVMTVKGGKKRIQVKKVFPGYLFIRMIEDEDVIRMIRNTTGVTGFVGTPGRPSTLNPQEEHWIRRFLEQKEIRPELKVKKGDRVYIKSGPFMGYEGFVDEVYPEKGTVRVLLSIFGRETPTEIDHTQVEKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0K5</accession>
    <name>B8E0K5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="8" type="ordered locus">Dtur_1376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583729.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353264.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1376"/>
    <dbReference type="EnsemblBacteria" id="ACK42650">
        <property type="protein sequence ID" value="ACK42650"/>
        <property type="gene ID" value="Dtur_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1376"/>
    <dbReference type="HOGENOM" id="CLU_2733549_0_0_0"/>
    <dbReference type="OMA" id="ELKKVMW"/>
    <dbReference type="OrthoDB" id="2195969at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="71" mass="8137" checksum="4EE61B7F28C8C935" modified="2009-03-03" version="1">MSRKISVVDRIKSFWVDEKLELKKVMWPDKNKVLQLSLALGVTLILLILIISLYDFIFGILSRLILGSFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0L0</accession>
    <name>B8E0L0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
            <ecNumber evidence="6">3.2.1.24</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584105.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353644.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1758"/>
    <dbReference type="CAZy" id="GH38">
        <property type="family name" value="Glycoside Hydrolase Family 38"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK43030">
        <property type="protein sequence ID" value="ACK43030"/>
        <property type="gene ID" value="Dtur_1758"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1758"/>
    <dbReference type="eggNOG" id="COG0383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003442_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0L0"/>
    <dbReference type="OMA" id="GQYWDAW"/>
    <dbReference type="OrthoDB" id="299689at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="522"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1032" mass="122090" checksum="0E38C218DFD40517" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0P2</accession>
    <name>B8E0P2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584136.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353676.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1790"/>
    <dbReference type="EnsemblBacteria" id="ACK43062">
        <property type="protein sequence ID" value="ACK43062"/>
        <property type="gene ID" value="Dtur_1790"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1790"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1842"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0P2"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019240">
        <property type="term" value="P:citrulline biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="154"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="57"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="233"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="269"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK43062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="309" mass="34757" checksum="540A374F2EC42BD4" modified="2009-03-03" version="1">MGNLKGRDLLSILDLSREDMEQIFHLAKNLKSEYYAGKKIHDYLKGKTVALFFEKPSTRTRISFEVGVYQLGGYPLYLNAQEMQLKRGETIADTARVLERYVDGIMARVYSHDTLVELAQHSSIPVINGLSDLEHPCQIIADYFTIIEKKGFRKLKVVYLGDGNNVANSLILAGAILGMNVVCSSPFQFMPPKKILDEANNLAKKYGGKVEIVEDPKEAVKGADVIYTDVWVSMGQEEEKELRKRVFPPYQVNKELVSLAKEDVIVMHCLPAHRGEEITDEVIDGPNSVVFDEAENRLHVQKAIMALLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0R7</accession>
    <name>B8E0R7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583732.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353268.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1380"/>
    <dbReference type="EnsemblBacteria" id="ACK42654">
        <property type="protein sequence ID" value="ACK42654"/>
        <property type="gene ID" value="Dtur_1380"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1380"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1425"/>
    <dbReference type="HOGENOM" id="CLU_2081048_0_0_0"/>
    <dbReference type="OMA" id="ADIYEIH"/>
    <dbReference type="OrthoDB" id="2143134at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="117" mass="13836" checksum="FC76EFF0F7E55406" modified="2009-03-03" version="1">MTINLARILDFVIFGVIIVFLIFLYRLLSSSQGKIADIYEIHKKIDELSEKEEYLRREVREITDIIRALRTQELALMEEIKKVTEKQSSTINLQELEQKINLLDKKLTRILEILMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0T9</accession>
    <name>B8E0T9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583754.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353290.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1402"/>
    <dbReference type="EnsemblBacteria" id="ACK42676">
        <property type="protein sequence ID" value="ACK42676"/>
        <property type="gene ID" value="Dtur_1402"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1402"/>
    <dbReference type="HOGENOM" id="CLU_1746734_0_0_0"/>
    <dbReference type="OMA" id="IHKSASF"/>
    <dbReference type="OrthoDB" id="2171106at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="149" mass="17788" checksum="B7BEB24BE0412EF7" modified="2009-03-03" version="1">MRKVLIFVFAFLIGILQTQIRVLGVVPDFLVIFFVFLVFKKKYFQGISLIFILISRMFSSAPVVGIVLYWAIMEVIIGIWRRSFIYIHKSASFFLVISLSVYSFIFWRTGYRVDVNYWLNFLKYLSINLLFFIPLYFLIPEIYSNEEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0U5</accession>
    <name>B8E0U5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide pyruvyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583760.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353296.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1408"/>
    <dbReference type="EnsemblBacteria" id="ACK42682">
        <property type="protein sequence ID" value="ACK42682"/>
        <property type="gene ID" value="Dtur_1408"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1408"/>
    <dbReference type="eggNOG" id="COG2327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039510_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0U5"/>
    <dbReference type="OMA" id="TVAWAQG"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019896">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase_CsaB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03609">
        <property type="entry name" value="S_layer_CsaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
        <location>
            <begin position="14"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="341" mass="40439" checksum="9307EA31BE7CAEDA" modified="2009-03-03" version="1">MLKLLFFGYYGEGNLGDDLLLKSLITVFGDKYNLGVLTNRSDRKQQQKGIREFYKFSTDVFKGVRWADVVVGGGGGIFQDKTSSRSFYYYIFVLFLSLLFGKRVYLLGQSFSPLESKINEVFLRVFLNRIEKIYVRDSFSKEYLVKLGVKPEKIVLSADLVFLLDFPFELKNNSRAVGISLREWRGFKFEEFNPILENLIQKYGEFYFFSFQDKDSQIYELIENDFKSKIRLINPTDLEFLSYFSSCRLFIGMRLHSCILSVLLGIPFIAISYDEKVEAFCYEIDWKFVIKDFSQDKILCYVNEIEEDYQYYRNYLLSKRESLRKKIREDILDFEREICRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0V7</accession>
    <name>B8E0V7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="9" type="ordered locus">Dtur_1420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_012583772.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    <dbReference type="RefSeq" id="YP_002353308.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    <dbReference type="STRING" id="515635.Dtur_1420"/>
    <dbReference type="EnsemblBacteria" id="ACK42694">
        <property type="protein sequence ID" value="ACK42694"/>
        <property type="gene ID" value="Dtur_1420"/>
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    <dbReference type="KEGG" id="dtu:Dtur_1420"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1467"/>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_003100_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0V7"/>
    <dbReference type="OMA" id="FIEPYQG"/>
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    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="2"/>
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    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
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    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
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    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
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    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
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    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
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    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="8">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="76"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="191"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="427"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="558"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="301"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>ATP</name>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="520"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="712" mass="79111" checksum="D2CE0BC15AAC044E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0W6</accession>
    <name>B8E0W6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ileS</name>
        <name evidence="14" type="ordered locus">Dtur_1429</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583781.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353317.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1429"/>
    <dbReference type="EnsemblBacteria" id="ACK42703">
        <property type="protein sequence ID" value="ACK42703"/>
        <property type="gene ID" value="Dtur_1429"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1429"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1476"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_1_1_0"/>
    <dbReference type="InParanoid" id="B8E0W6"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="PTHR42780"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="18"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="13">
        <location>
            <begin position="677"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="589"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="592"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="975" mass="114859" checksum="BA84555DD62B6623" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0X6</accession>
    <name>FMT_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">Dtur_1439</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583791.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353327.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0X6"/>
    <dbReference type="SMR" id="B8E0X6"/>
    <dbReference type="STRING" id="515635.Dtur_1439"/>
    <dbReference type="EnsemblBacteria" id="ACK42713">
        <property type="protein sequence ID" value="ACK42713"/>
        <property type="gene ID" value="Dtur_1439"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1439"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1486"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_0"/>
    <dbReference type="InParanoid" id="B8E0X6"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071951">
        <property type="term" value="P:conversion of methionyl-tRNA to N-formyl-methionyl-tRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000118475" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="109"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <sequence length="314" mass="35509" checksum="076B0305DF96FD3B" modified="2009-03-03" version="1">MRIIYFGTPEFSRIILERISPYLNIIAVVTQPDKPKGRGKRIMCSPVKDFAISKGIPVYQPEKLKGNKEFFEIIRSLNPEALVVASYGKIIPEDILNIPPYGGINVHASVLPKYRGAAPIERAIMNCEKETGVSIMKMERGLDTGPVYAIRKIPILPDDNRGTLSIKLAHLGAELLLEVLPLIKDGKLSPVPQEESLATYAPKLSKEEEIIDWNMRGEKIWCQIRALSPEPGAMTFFRGKILKIFKADFEEKIFNEEIINGTIIEQNKKRGIGVKVNNGILWLLELQPEGKKRMSFLEFMNGYRLNIGERFENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Z6</accession>
    <name>B8E0Z6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353347.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1459"/>
    <dbReference type="EnsemblBacteria" id="ACK42733">
        <property type="protein sequence ID" value="ACK42733"/>
        <property type="gene ID" value="Dtur_1459"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1459"/>
    <dbReference type="HOGENOM" id="CLU_3269166_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="41" mass="4793" checksum="8BF704A54A06B64C" modified="2009-03-03" version="1">MFCCEDCPYYKECLNHKVGCCSKCPHYNECYDVKEGYNSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Z7</accession>
    <name>B8E0Z7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="3">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Spermidine synthase</fullName>
            <shortName evidence="3">SPDS</shortName>
            <shortName evidence="3">SPDSY</shortName>
            <ecNumber evidence="3">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">speE</name>
        <name evidence="6" type="ordered locus">Dtur_1460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583812.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353348.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1460"/>
    <dbReference type="EnsemblBacteria" id="ACK42734">
        <property type="protein sequence ID" value="ACK42734"/>
        <property type="gene ID" value="Dtur_1460"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1460"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1509"/>
    <dbReference type="eggNOG" id="COG0421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0Z7"/>
    <dbReference type="OMA" id="WIPSFGY"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="3"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="3">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="304" mass="35376" checksum="CDB350FF372BA3B1" modified="2009-03-03" version="1">MDAYWIIEKNHPSEIHWHGVSRFYYTGVSPFQKIEIIESTFYGKCLVLDGRIQSSEKDEFIYHEALVHPALLLNRAANKKVLIMGGGEGATLREVLRHKDVTEAIMVDIDGEVVEVSKKYLPEWHQGAFDDPRTRLYITDAREFVEKSKEKYDVIVSDLSEPMEGSPAVKLFTFEFYHIIKDHLKEDGIFVMQAGTTHHLKIAFHSAMNSTLRRVFKIVRSYQAYVPAYDFIWSFIWASDKIDPKDFSEEEINSLLKSKNLANLKFYDGETHKMMFSLPKHLRELIEREERVAYDNAPLYAVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E107</accession>
    <name>B8E107_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidase M50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Dtur_1470</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583822.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353358.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1470"/>
    <dbReference type="EnsemblBacteria" id="ACK42744">
        <property type="protein sequence ID" value="ACK42744"/>
        <property type="gene ID" value="Dtur_1470"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1470"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086979_1_1_0"/>
    <dbReference type="InParanoid" id="B8E107"/>
    <dbReference type="OMA" id="HEIMHGL"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="164"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="116"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACK42744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="200" mass="22632" checksum="D8E221CE4F343C65" modified="2009-03-03" version="1">MEFSNLVTYLWRIIAILIAITVHEFAHGKMAEIEGDITPRLSGRLTLNPLAHIDPIGFLMLLLFRFGWAKPVPVNFDNLRRGDKSVILVSLAGPLANFSLAFLVSIFWRFDLPVPIGFVSFCIELAILNVFLGIFNLIPIPPLDGSHILEALLPYKYKRYYQSIGIYGVLILMILILTNGLYIIISPLLNLFLYLLGLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E110</accession>
    <name>B8E110_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">xerC</name>
        <name evidence="14" type="ordered locus">Dtur_1473</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583825.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353361.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1473"/>
    <dbReference type="EnsemblBacteria" id="ACK42747">
        <property type="protein sequence ID" value="ACK42747"/>
        <property type="gene ID" value="Dtur_1473"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1473"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1522"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_0"/>
    <dbReference type="OMA" id="HRFLYAE"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="104"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="296" mass="34931" checksum="EE9DB41C3DB43D27" modified="2009-03-03" version="1">MKDKLEDFLFYLKFEKNMSPNTIDSYRRDLEDFIIFLQKEKVNIKNLKREEWQRYLVSLYNRYKIKSIARKISSIRSFLKFLLREGYINRNYSSFMIIPKIPMYLPEILDNKEIENFLKIPDPLSPLGIRNIAILETFYATGMRVSELVNLDVQSINLEEKYVRCFGKGDKERIIPLGDYAVESLKKYLLVRDSFNPKDEKALFLNKKGERITRQGVWFIIKTYSKILGLPKKVSPHTFRHSFATHLLSNGADIRIVQELLGHSDVATTQIYTHIVSSKLHEVYQKAHPLTRRNDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E114</accession>
    <name>B8E114_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ycf81 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583829.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353365.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1477"/>
    <dbReference type="EnsemblBacteria" id="ACK42751">
        <property type="protein sequence ID" value="ACK42751"/>
        <property type="gene ID" value="Dtur_1477"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1477"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1526"/>
    <dbReference type="eggNOG" id="COG4956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050839_1_1_0"/>
    <dbReference type="InParanoid" id="B8E114"/>
    <dbReference type="OMA" id="TNDFNLM"/>
    <dbReference type="OrthoDB" id="940436at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="3">
        <location>
            <begin position="196"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="269" mass="30553" checksum="AFE38EFCEEF2266D" modified="2009-03-03" version="1">MRKNWKLLLIVTFIPFMGDFVLSSYLLCSNFRNLWNMFNFIFSLLVLSIYIIFARKIRFFDLVNFPYVKILDTSVIIDGRIVDVLKTNFIEGKIIIPRFVLKELQQLADSSESLKKNRGRFGLDNLSQIRKELGSQVIIVDMDFPKVQSVDSKLVKLAKTLGGKIITNDYGLNKLAKIEGITVLNINELANALKPIYLPGEEILISIIKEGKEPGQGVGYLEDGTMVVVENGKKYIGQTVKVTVTSVFQTAAGRLIFGRVKEEKEHWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E125</accession>
    <name>B8E125_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583840.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353376.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1488"/>
    <dbReference type="EnsemblBacteria" id="ACK42762">
        <property type="protein sequence ID" value="ACK42762"/>
        <property type="gene ID" value="Dtur_1488"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1488"/>
    <dbReference type="eggNOG" id="COG2316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090635_1_0_0"/>
    <dbReference type="InParanoid" id="B8E125"/>
    <dbReference type="OMA" id="EMLGWEL"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="1">
        <location>
            <begin position="15"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="183" mass="20726" checksum="D1223FEEB5546F56" modified="2009-03-03" version="1">MNRDEALDKVKKYVKNKNLIKHMLATEAIMRALAKRFNEDEEKWGLTGLLHDIDYEITEKEPEKHSLLAEELLKDENLSKDVIDAIKAHNEIHNLPRETLLAKALYAVDPLTGLIVAAALIHPEKKLAPLDVNFILNRFKEKSFARGANRDQIKTCEDLGLSLEEFIAIGLEAMKSISDELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E131</accession>
    <name>B8E131_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583846.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353382.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1494"/>
    <dbReference type="EnsemblBacteria" id="ACK42768">
        <property type="protein sequence ID" value="ACK42768"/>
        <property type="gene ID" value="Dtur_1494"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1494"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1543"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_0"/>
    <dbReference type="InParanoid" id="B8E131"/>
    <dbReference type="OMA" id="QTQHLGQ"/>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="323"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="404" mass="44765" checksum="27048D1882603D11" modified="2009-03-03" version="1">MISLKDIESSRERISPFIHKTPISFSQTFSDMTRKEVFLKFENLQKTGAFKIRGAINYISQLKKIKGVITASAGNHAQGVAYASKIFGISSTIVMPENTPLIKILSTKNYGAKIILHGKVYDDAFYYAKELAKEENLEFVPAFDDEKIIAGQGTIGLEILEDLKEIEALIVPIGGGGLASGILIALKETNPKIKVYGVQSNAFPYMYEKIKKVEIPQKPEQTIAEGIAVKKPGEITSSIIETYIDDIFVVEEEKIAEAVLLLLERAKTLVEGAGASTLAALLKYYTEIPEEKIVLILSGGNIDVSLLTKIIEFGLMEAGRIVHMKVKLPDLPGHLSEVIDVISKEKANIITIHQDPSLPFFPKIESNVEFTLETKNPDQIRRIFDKIKEKGYEIEILEKGGIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E151</accession>
    <name>B8E151_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="5">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0898</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583263.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352793.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0898"/>
    <dbReference type="EnsemblBacteria" id="ACK42179">
        <property type="protein sequence ID" value="ACK42179"/>
        <property type="gene ID" value="Dtur_0898"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0898"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.935"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_2_0"/>
    <dbReference type="InParanoid" id="B8E151"/>
    <dbReference type="OMA" id="RVDGYWE"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="265" mass="30233" checksum="1FE968197155D4C1" modified="2009-03-03" version="1">MKRILEVAIKTIKESGNILLNYIGEEKEIELKGISNLVTQVDKLSERHILKSIEENFPDHSILTEETGFINKNSEYTWIVDPLDGTTNYAHNFPFFGISIALIKNKEIILGLIYDPIRDELFYAIKNEGAYLNDRRIEVSKTESLENSLISFAFPYELSLEEKNFIPFINFSSRTHGIRRTGSAAIEIAYVGCGRLDGFWAKKLKPWDISAGILIVEEAKGKVTDFSGNNIDIHTDNILFSNGKIHQEMIKILNLGKIFIRNEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E152</accession>
    <name>B8E152_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATPase AAA-2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583264.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352794.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0899"/>
    <dbReference type="EnsemblBacteria" id="ACK42180">
        <property type="protein sequence ID" value="ACK42180"/>
        <property type="gene ID" value="Dtur_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0899"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_2_0"/>
    <dbReference type="InParanoid" id="B8E152"/>
    <dbReference type="OMA" id="SKMMQGE"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="7">
        <location>
            <begin position="83"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="495"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="894" mass="101336" checksum="95510F8FFF066273" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E163</accession>
    <name>B8E163_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DRTGG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583275.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352805.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0910"/>
    <dbReference type="EnsemblBacteria" id="ACK42191">
        <property type="protein sequence ID" value="ACK42191"/>
        <property type="gene ID" value="Dtur_0910"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0910"/>
    <dbReference type="eggNOG" id="COG4109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140224_0_0_0"/>
    <dbReference type="InParanoid" id="B8E163"/>
    <dbReference type="OMA" id="CVRTAGV"/>
    <dbReference type="OrthoDB" id="1858096at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012914">
        <property type="entry name" value="PucR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07905">
        <property type="entry name" value="PucR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="6"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="PucR" evidence="2">
        <location>
            <begin position="9"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="119" mass="12923" checksum="365E42495B64A09A" modified="2009-03-03" version="1">MTLGKVREILKAQVLCGEENLNREISIVGATDLMSDALCLLEEGALLLTGLITIQVVRTAEMLDLVGVVFVRGKIPPKDVIDLARKSNLPLLSTKYPMYEACGLLYTAGFKGKKVDVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E189</accession>
    <name>B8E189_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583301.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352831.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0936"/>
    <dbReference type="EnsemblBacteria" id="ACK42217">
        <property type="protein sequence ID" value="ACK42217"/>
        <property type="gene ID" value="Dtur_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0936"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.973"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="InParanoid" id="B8E189"/>
    <dbReference type="OMA" id="IMMQKIM"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015807">
        <property type="term" value="P:L-amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="234" mass="25852" checksum="7B0D984CD2328380" modified="2009-03-03" version="1">MLSIRDLHVYYGGIKALQGINIDVNEGEVVALVGANGAGKTTTLRSIFRLTPIVKGDIFFYEINLTKVPTHRVASLGIAHVPEGRRVFPNMTVRENLEMGAFLIKDKNIIKNNLDFVYSLFPRLKEREKQLAGTLSGGEQQMLAIGRALMSNARLLLLDEPSMGLAPLLVQEIFSVLKKINEEKRTLLLVEQNANMAFSIAHRVYVMETGKIVLSGTTQEVANNEAVKKAYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1B5</accession>
    <name>B8E1B5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583327.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352857.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0963"/>
    <dbReference type="EnsemblBacteria" id="ACK42243">
        <property type="protein sequence ID" value="ACK42243"/>
        <property type="gene ID" value="Dtur_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0963"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1000"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_3_0"/>
    <dbReference type="InParanoid" id="B8E1B5"/>
    <dbReference type="OMA" id="GERYLNY"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="157" mass="18504" checksum="5F2B39326195361A" modified="2009-03-03" version="1">MQDQKESNELSVEIRPMKFEDIDQVDEINKLSFSNPWSRESFERELSSNRIAHYFVAIHENKIIGFVGLWIIFQEAQITTIAVHPNYRGRKVGEKLLDFIIDYCQKNLVKNIILEVRVSNTIAQNLYYKKGFKKVGVRKWYYKDGEDALVMVKKLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1B7</accession>
    <name>B8E1B7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583329.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352859.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0965"/>
    <dbReference type="EnsemblBacteria" id="ACK42245">
        <property type="protein sequence ID" value="ACK42245"/>
        <property type="gene ID" value="Dtur_0965"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0965"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1002"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_3_0_0"/>
    <dbReference type="InParanoid" id="B8E1B7"/>
    <dbReference type="OMA" id="FTDDAIC"/>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="156" mass="17939" checksum="BE0D63CD75981135" modified="2009-03-03" version="1">MEVLSKSPLETKELGKALGNLLNPGNILALIGDLGSGKTTFVQGISQALHITIPVNSPSFLIIKEYKGKHRMLHIDVYRLKIPERELENIGFEEYLNSDFIIVIEWADKIRGLLPKERMEITFEHVDFNERLIKFKPYGEKYENLLLELKKCLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1C7</accession>
    <name>B8E1C7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="10" type="ordered locus">Dtur_0975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="WP_012583339.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    <dbReference type="STRING" id="515635.Dtur_0975"/>
    <dbReference type="EnsemblBacteria" id="ACK42255">
        <property type="protein sequence ID" value="ACK42255"/>
        <property type="gene ID" value="Dtur_0975"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0975"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1012"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="InParanoid" id="B8E1C7"/>
    <dbReference type="OMA" id="YRNIRVE"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="term" value="P:transcription, DNA-templated"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA-dir_RpoC2_beta_pp"/>
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        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
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    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
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        <property type="entry name" value="RNA_pol_N"/>
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        <property type="entry name" value="RNA_pol_Rpb1_1"/>
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        <property type="entry name" value="RNA_pol_Rpb1_4"/>
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        <property type="entry name" value="RNA_pol_Rpb1_5"/>
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    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
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        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02388">
        <property type="entry name" value="rpoC2_cyan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="9">
        <location>
            <begin position="223"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="452"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="786"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="859"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="866"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="869"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1427" mass="160788" checksum="77FAFCC847681A7B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1D6</accession>
    <name>RL2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplB</name>
        <name type="ordered locus">Dtur_0984</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="ACK42264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352878.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    <dbReference type="SMR" id="B8E1D6"/>
    <dbReference type="STRING" id="515635.Dtur_0984"/>
    <dbReference type="EnsemblBacteria" id="ACK42264">
        <property type="protein sequence ID" value="ACK42264"/>
        <property type="gene ID" value="Dtur_0984"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0984"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1021"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_036235_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1D6"/>
    <dbReference type="OMA" id="SCIELRP"/>
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    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="F:transferase activity"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
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        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
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    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
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    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
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    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
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    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
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    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
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    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
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        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000141542" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="229"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="280" mass="31110" checksum="C817A3B5CE39DAEF" modified="2009-03-03" version="1">MGLKKFKPITPGLRHLILPDFSEITKEEPEKSLLRPLKKSGGRNNFGHVTTRFRGGGHKRLYRIIDFRRDKDNIPAKVASIEYDPNRTARIALLHYADGEKRYIIAPEGLKVGDIVMSGENVDIKVGNNLPLKNIPDGTLIHNLELYPGRGGQLVRAAGTAAQILGKEGKWAYVRLPSGEIRLFDLNCRATIGQVSNVDHQNVSLGKAGRSRWLGRRPHVRGSAMNAVDHPHGGGEGKAPIGHPSPLTPWGKPTLGYKTRKKRKPSDRFIIQRANDKKEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1G6</accession>
    <name>RL13_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplM</name>
        <name type="ordered locus">Dtur_1014</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583377.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352908.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1G6"/>
    <dbReference type="SMR" id="B8E1G6"/>
    <dbReference type="STRING" id="515635.Dtur_1014"/>
    <dbReference type="EnsemblBacteria" id="ACK42294">
        <property type="protein sequence ID" value="ACK42294"/>
        <property type="gene ID" value="Dtur_1014"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1014"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1051"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_0"/>
    <dbReference type="InParanoid" id="B8E1G6"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000144119" description="50S ribosomal protein L13">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <sequence length="142" mass="16163" checksum="522703645909B46D" modified="2009-03-03" version="1">MKTFMAKKEEIKREWYVVDAKGKVLGRLASEIAKILRGKHKPIYTPHVDTGDFVIVVNAKDVVLTGKKEDQKIYFFHSGYPGGHRLITARDMRAKSPEKMIYLAVKGMLPKGPLGRKMLKKLKIYAGPEHPHQAQKPKELNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1I5</accession>
    <name>B8E1I5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ste24 endopeptidase</fullName>
            <ecNumber evidence="12">3.4.24.84</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_0181</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="12"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582595.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352124.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0181"/>
    <dbReference type="EnsemblBacteria" id="ACK41510">
        <property type="protein sequence ID" value="ACK41510"/>
        <property type="gene ID" value="Dtur_0181"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0181"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1I5"/>
    <dbReference type="OMA" id="LPFKIYK"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="11">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="202"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK41510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="408" mass="47718" checksum="438109600A8E358F" modified="2009-03-03" version="1">MFLGIFLIFIIGKVLIHAYLNLRNLKHSLSHKEVPEVLKDIITNEELKKAQEYLKDNTVLGLISQAFDLIFTLIFLFLFYPYIEKIVSSITSSFIMQGLLFFGISGLINLILSLPFEVYDIFVIEQKYGFNTMTPKIFILDIIKSIILSIILGVPILSLLLYIIKTDPNFWWKFALVIVLFEIFVYYIYPILIAPLFNKFTPLEEGDLKNRIIEIVNKAGFKVNNIFVMDASRRTKKQNAYLTGFGKTRRVVLFDTMLSYPQEEILAVLAHELGHHKKKHIPKLLILSIVFYLLYIYLTFFVYKNAPFSKYFGITKEFSILLYSFLFVSSIFYFINPLVNALSRKFEYEADKFSAEVFGNPFPLTNALKRLIKENLSNIYPDPIFRTWYYSHPAPVERIYNLLTFQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1J4</accession>
    <name>B8E1J4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582604.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352133.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0190"/>
    <dbReference type="EnsemblBacteria" id="ACK41519">
        <property type="protein sequence ID" value="ACK41519"/>
        <property type="gene ID" value="Dtur_0190"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0190"/>
    <dbReference type="HOGENOM" id="CLU_1084748_0_0_0"/>
    <dbReference type="OMA" id="TITTHFW"/>
    <dbReference type="OrthoDB" id="2147461at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="252" mass="28606" checksum="97169654D9B2BF0A" modified="2009-03-03" version="1">MEKGLRVVEVSLFLSLFVVILLSFLPLLNVSISNQIYDFVYLLAEIIGLLFALIYALKIDKNQKLWLGWFFILLGLGAYFLKDLLNFLDQQNLSGILGILSFILIFVGILIFIIFISNSLRLRLTFNENFLLVINAILLFILILQVGLLPTLLSKDPLWDKVISVIYLLGNYFILVVFMILFLTVTTNFWGGEIARNYYLLALGIALLSVASIIFSYVLGSYELLKLDKIIYLGAYLVIVYAIVKEGLMHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1K6</accession>
    <name>B8E1K6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">8-oxoguanine DNA glycosylase/AP lyase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="3">8-oxoguanine DNA glycosylase</fullName>
                <shortName evidence="3">8-oxoG DNA glycosylase</shortName>
                <ecNumber evidence="3">3.2.2.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
                <shortName evidence="3">AP lyase</shortName>
                <ecNumber evidence="3">4.2.99.18</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">ogg</name>
        <name evidence="5" type="ordered locus">Dtur_0202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-2 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="3"/>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582616.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352145.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0202"/>
    <dbReference type="EnsemblBacteria" id="ACK41531">
        <property type="protein sequence ID" value="ACK41531"/>
        <property type="gene ID" value="Dtur_0202"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0202"/>
    <dbReference type="eggNOG" id="COG1059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104937_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1K6"/>
    <dbReference type="OMA" id="FCILTAN"/>
    <dbReference type="OrthoDB" id="1534544at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00241">
        <property type="entry name" value="Ogg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012092">
        <property type="entry name" value="DNA_glyclase/AP_lyase_Ogg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005954">
        <property type="entry name" value="Thrmst_ogg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="4">
        <location>
            <begin position="50"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="site" description="Important for guanine/8-oxoguanine distinction" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="211" mass="24459" checksum="61F7E618A3AA04ED" modified="2009-03-03" version="1">MSKYKSALEKIKSIEEIAYPVVEKRIREFEALGKYGDELDLFSELSFCVLTANWSAQGGIKAQNIIGKVNFAQLSLEKLVEKLKEVGHRYPITRAKFIVENRKLIGSLRNIWRKPSIEAREILIREAKGIGWKEASHFLRNTGKLDVAILDKHILRFLFNEGIINEIPKSWTWKKYENIEKEFTELSSLLGKTPGETDLYIWYLLKGKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1L5</accession>
    <name>B8E1L5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582625.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352154.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0211"/>
    <dbReference type="EnsemblBacteria" id="ACK41540">
        <property type="protein sequence ID" value="ACK41540"/>
        <property type="gene ID" value="Dtur_0211"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0211"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_0"/>
    <dbReference type="InParanoid" id="B8E1L5"/>
    <dbReference type="OMA" id="LLIFDWD"/>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="213" mass="25319" checksum="FDFFFC7D69624D0B" modified="2009-03-03" version="1">MELKGIIFDWDGTLVDSFPACIKATKEIFKKFGFIISEEEYREKFSPNWYDIYRKHNIPEKYWKEIDLLWKDYFDYSLVKWREGAVENLTFLKKLNLKIGVVTASTKEDIEREKPYLNPEEYIDGWITWEDSEKPKPDPLPLLKILKKLSLSPLEVIYVGDTKEDIEMSKKLNILTIGVLSPFTQKEKLVSSNPNFLFNNLFELLKFWKDLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1M2</accession>
    <name>B8E1M2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582632.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352161.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0218"/>
    <dbReference type="EnsemblBacteria" id="ACK41547">
        <property type="protein sequence ID" value="ACK41547"/>
        <property type="gene ID" value="Dtur_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0218"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8E1M2"/>
    <dbReference type="OMA" id="PEIDRKW"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="274" mass="31184" checksum="A9B4863C1ECC1E1C" modified="2009-03-03" version="1">MALLEVKNLNKIYEVGLFVRRQIHAVKSINFSVERGEIVSLVGESGSGKTTTAKMILRLEKPTSGDIIVEGINVWKDIKTVEDKKNYYRKVHAVFQDPFASYNQFYPIDRILHQALRLIDVDPNNPKSKELIEEALIHVGLEPKNILGKYPHQLSGGEKQRIMIARCWLLKPSLIIADEPVSMIDASTRGGIIKLFENLRDETGTSIIFITHDMGLAYYISNRIFIMYKGEIVEEGTPDDIISNPKHDYTKNLIGSIPTLYKKWEDIGELETRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1N0</accession>
    <name>B8E1N0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582640.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352169.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0226"/>
    <dbReference type="EnsemblBacteria" id="ACK41555">
        <property type="protein sequence ID" value="ACK41555"/>
        <property type="gene ID" value="Dtur_0226"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0226"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_5_0"/>
    <dbReference type="InParanoid" id="B8E1N0"/>
    <dbReference type="OMA" id="SSICYPL"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="5">
        <location>
            <begin position="579"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="4">
        <location>
            <begin position="601"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="770" mass="89822" checksum="E3588EAE67BE7122" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1N8</accession>
    <name>B8E1N8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582648.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352177.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0234"/>
    <dbReference type="EnsemblBacteria" id="ACK41563">
        <property type="protein sequence ID" value="ACK41563"/>
        <property type="gene ID" value="Dtur_0234"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0234"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054927_3_1_0"/>
    <dbReference type="InParanoid" id="B8E1N8"/>
    <dbReference type="OMA" id="NFFIDMS"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="292" mass="34578" checksum="15CDC95FF4C2101A" modified="2009-03-03" version="1">MEKEKLDLEFLEKLEKLRLAVKRLRFRSHLGERKSPKMGRGTEFSDYRSYQVGDELRYLDWNIYARFEKFLVKLFEEEEDVEVHILLDASSSMDFGNPTKFFYGKKLALAFSYLSLSSWEKTTFSYFQDKIKEILPLERKKENIYRLLNLLNEIKAEGNTNITETVKKYASSLKRKGILIIISDLLSSEFEEGIIYARYKKMPVYLIHTICEEEISPFFSGNLTLIDSETGEKMDILLDEYMIQKYQKALEKFLNHIESFTMLYNVEYLRSITSIPIEDLILKYLRVGGWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1S5</accession>
    <name>B8E1S5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5-carboxymethyl-2-hydroxymuconate Delta-isomerase</fullName>
            <ecNumber evidence="2">5.3.3.10</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.3.3.10" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582793.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352322.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0404"/>
    <dbReference type="EnsemblBacteria" id="ACK41708">
        <property type="protein sequence ID" value="ACK41708"/>
        <property type="gene ID" value="Dtur_0404"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0404"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.426"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_3_1_0"/>
    <dbReference type="InParanoid" id="B8E1S5"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008704">
        <property type="term" value="F:5-carboxymethyl-2-hydroxymuconate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="91"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="297" mass="34245" checksum="55F3C83D1DD9A71D" modified="2009-03-03" version="1">MKIANLKSGERFFIGLLFEDKILNLTKAILMYSSIYEKNLRYVEKIDDILYMDNLQEYLNKVQDFIFEHNLIYSLTEEKYKFLPPIIKPQKILALGRNYVEHAKELGHKVPREPVFFSKSPSSLIAHEEEIVYPNFLTRVDPEVELGVIIKKRGKYIKEENAMDYVLGYTVVNDVTARDMQAEDFSNTNPWFRSKSFDTFCPVGPYLVLKEGIKDPHNLNIELRVNGEMRQKDNTKNMIFKIPQIISYISKHLTLQAGDIIATGTPSGISPIYPGDTVECIVEKVGVLRNEVVNEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Z5</accession>
    <name>B8E1Z5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582863.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352392.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0478"/>
    <dbReference type="EnsemblBacteria" id="ACK41778">
        <property type="protein sequence ID" value="ACK41778"/>
        <property type="gene ID" value="Dtur_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0478"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.504"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_3_0_0"/>
    <dbReference type="InParanoid" id="B8E1Z5"/>
    <dbReference type="OMA" id="WKHGIET"/>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="2">
        <location>
            <begin position="120"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="218" mass="25454" checksum="93FAC5F52331C7F0" modified="2009-03-03" version="1">MLRQSFIEELKKLENSLLEMGNVVKQMLENSKTALLERDEELAKKVIEMDDIVDKYNWDIEDKCLKLLALQQPMAHDLRVIAAAMKIISDIERMGDYCVDIAKFTIELIKMPSLPINEALIKMFELVEKILCDSLEAFVNRDVNFIISVVEQDDAIDRTYYKIYDEIVEEIEHAPETAPQQIRLLMIARFLERVADHVTNVAERIYYMETGELKELHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E232</accession>
    <name>B8E232_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583392.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352923.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1029"/>
    <dbReference type="EnsemblBacteria" id="ACK42309">
        <property type="protein sequence ID" value="ACK42309"/>
        <property type="gene ID" value="Dtur_1029"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1029"/>
    <dbReference type="HOGENOM" id="CLU_1466010_0_0_0"/>
    <dbReference type="OMA" id="SLGYQFI"/>
    <dbReference type="OrthoDB" id="2114989at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="184" mass="21095" checksum="A027DFBCF6E6E017" modified="2009-03-03" version="1">MRKGYTLVELLISISIVLIVIALVVNFLITGSLGYQFINKKVQYQRNARLVAERMIREVKKASLIDSASDGSNLIFSYTYYDFSTNPISSTLSTVKYYVDSNGILRRQVKQGSLWVGNNPLTESDFKILTPIFYYYNSARRLVSPQNAELIEIVLKFDGDKNNIPDYTLTFNIFLPVRSVYYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E244</accession>
    <name>B8E244_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583404.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352935.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1041"/>
    <dbReference type="EnsemblBacteria" id="ACK42321">
        <property type="protein sequence ID" value="ACK42321"/>
        <property type="gene ID" value="Dtur_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1041"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1515589_0_0_0"/>
    <dbReference type="OMA" id="NIRGKIM"/>
    <dbReference type="OrthoDB" id="2131115at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="177" mass="20131" checksum="751C6184B7AAE400" modified="2009-03-03" version="1">MRINKSERITTFLLLFISALIYVILILALLKWSPALSFLGWASHQGFLFVLIFLIVLFVVSFSMSFFYLLFREKTTISLGNTSGLGEISISLNGIKNAIREIAAYFSEIQEIRPEIENLRGKIILTLRIKVPSGSDITRVVNELQHRVKVYFENVLTLNLENINIIIEDVVPAKKGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E281</accession>
    <name>MIAA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="1">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="1">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="1">IPP transferase</shortName>
            <shortName evidence="1">IPPT</shortName>
            <shortName evidence="1">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaA</name>
        <name type="ordered locus">Dtur_1079</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583441.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352972.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E281"/>
    <dbReference type="SMR" id="B8E281"/>
    <dbReference type="STRING" id="515635.Dtur_1079"/>
    <dbReference type="EnsemblBacteria" id="ACK42358">
        <property type="protein sequence ID" value="ACK42358"/>
        <property type="gene ID" value="Dtur_1079"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1079"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1115"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_0"/>
    <dbReference type="InParanoid" id="B8E281"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000118522" description="tRNA dimethylallyltransferase">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <sequence length="326" mass="38554" checksum="C9A15F5BDAC9073B" modified="2009-03-03" version="1">MKIPLAVILGPTGTGKTKLSLELAKYLPVEIVSVDSMQIYQGMDIGTAKPSLEDREKVPHHLIDIVLPDYFFTVAEFRERALKVIEEIYARRRFPLLVGGTPLYYKVLFGEFSIPHVPPDLEFRRKMKELAEKEGEYKLYEELKKIDPKTASKIHPRDLKRIIRALEVYYKVGKPISELAGEKKEDRFYISKIGLYMPRDLHYRILEERVDKMIEQGLVDEVRNLYLKGINENFVSMQGIGYKEILRYLRGELTLEESINLIKKRTKEFVKRQYTWFKKYKDIHWFDVSQYSLSQLAKLVYNTIINDWENQGYKYQNREGVNYFND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2A0</accession>
    <name>B8E2A0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heptaprenyl diphosphate synthase component I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583460.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352991.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1098"/>
    <dbReference type="EnsemblBacteria" id="ACK42377">
        <property type="protein sequence ID" value="ACK42377"/>
        <property type="gene ID" value="Dtur_1098"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1098"/>
    <dbReference type="eggNOG" id="COG4769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108933_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2A0"/>
    <dbReference type="OMA" id="PIPYFRI"/>
    <dbReference type="OrthoDB" id="2030916at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014535">
        <property type="entry name" value="Hpre_diP_synt_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010898">
        <property type="entry name" value="Hpre_diP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07456">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027391">
        <property type="entry name" value="Hpre_diP_synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="177" mass="19454" checksum="103D6584C99B4079" modified="2009-03-03" version="1">MKITNIRKNKIYYISLLGLLLSLACTLYYLESLFITPFFPLPGGKVGIANIISLIAIYMLGLKEALVITIFRVIIVNIILGGFLNISFYLGFFGGIASTLVMGALAKSNISLISNSIIGALTHNFVQLLIVMFFVFHSAILYYAPFLIIFGIITGFFNGVVGGYVLRFIKKYSGGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2B9</accession>
    <name>B8E2B9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol/glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_1117</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583479.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353010.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1117"/>
    <dbReference type="EnsemblBacteria" id="ACK42396">
        <property type="protein sequence ID" value="ACK42396"/>
        <property type="gene ID" value="Dtur_1117"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1117"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1153"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_6_2_0"/>
    <dbReference type="InParanoid" id="B8E2B9"/>
    <dbReference type="OMA" id="FVIFIYR"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00671"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="171" mass="19226" checksum="1DFED50E77733FE6" modified="2009-03-03" version="1">MTIPNIITLIRLVIIPFYTYFLLTQKLFIAAILYGIAAISDILDGYLARKLNQTSELGKIIDPIADKLIVIISLVYLGYKNILPLWGVLILLTKEFLMLLVGLFFLIKKVEIISSKIYGKLAMVLISISILMALLSIPFQNVVFLIGLVISLIAGIDYLFFYLNNLKANKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2D9</accession>
    <name>B8E2D9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein Dtur_1509</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583860.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353397.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1509"/>
    <dbReference type="EnsemblBacteria" id="ACK42783">
        <property type="protein sequence ID" value="ACK42783"/>
        <property type="gene ID" value="Dtur_1509"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1509"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1558"/>
    <dbReference type="eggNOG" id="COG1355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_2_0_0"/>
    <dbReference type="InParanoid" id="B8E2D9"/>
    <dbReference type="OMA" id="EQEAQYG"/>
    <dbReference type="OrthoDB" id="1070303at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="269" mass="30029" checksum="DD4D41DBA7B5AEAE" modified="2009-03-03" version="1">MKRRLPSVAGYFYPAREKELLNMLSQFIKEVPQKTPLLGCVVPHAGYIYSGKVAGLIYSIMEVPEVAIIIGPNHNGLGYPSAIYSEGVWATPLGDVEIDSILSRKIINNSKYLKEDFVAHHPEHSLEVQVPFLQYLNFNIKIVPITVVDYSYEVLKDLGYAIGKSLLDYEKNTVIIASSDFSHYEPYEIAKQKDFYAIEAILNLDEKEFIKRVVEKDISICGVGPIVITIIAVKLLGGRKAQLVAYQTSGDITKDIDQVVGYAGIIFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2E2</accession>
    <name>B8E2E2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PpiC-type peptidyl-prolyl cis-trans isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583863.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353400.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1512"/>
    <dbReference type="EnsemblBacteria" id="ACK42786">
        <property type="protein sequence ID" value="ACK42786"/>
        <property type="gene ID" value="Dtur_1512"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1512"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041768_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2E2"/>
    <dbReference type="OMA" id="QVRANMG"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="184"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="355" mass="42078" checksum="CAA4F7D439C3FC36" modified="2009-03-03" version="1">MKKHSIFKILFIVFVAIFILGGAFVALVYHQMKNYPVLKINGMPVSRQEYKDRLNFMKTQYSIMFNVDFTTTEGQKLLPKVKDETIKDLARWKIVQTEAKKRGISISEKEVDTRLKEIEKEFPSVLQFEMTLAQYGYDRNTFKEELRKNLLMRKLIDEIGKDEKVTEDEIKKYYNENIKLFEHPKEYKVYSILIKDEKRAKEVYNELTSNKITFTDAAKKYSEDTTTKDKGGELGFITQGTLPEEVEKITFTLPLNQISKPIKTNEGYYITKVTEVKEAYTTPYFQAKAEIEDKLLYDKRAKVFNKWLEDQVSKAKIERDFSDKDIWMRIWRKLIEIQQIFYRKEAKTPLPKTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2E3</accession>
    <name>B8E2E3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MazG family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583864.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353401.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1513"/>
    <dbReference type="EnsemblBacteria" id="ACK42787">
        <property type="protein sequence ID" value="ACK42787"/>
        <property type="gene ID" value="Dtur_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1513"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1562"/>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2E3"/>
    <dbReference type="OMA" id="HPHIYGD"/>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046061">
        <property type="term" value="P:dATP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046076">
        <property type="term" value="P:dTTP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046047">
        <property type="term" value="P:TTP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046052">
        <property type="term" value="P:UTP catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="31"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="2">
        <location>
            <begin position="163"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="258" mass="30527" checksum="74195AB0A75AD498" modified="2009-03-03" version="1">MDEKEKICKEFIDLYLVVKRVREECPWDQKQTSQTLIPYFLEESYELIDALEKDDSEMIKEELGDILLHILMQSIMAEEKNRFNFEEVCKNLKIKLITRHPHVFGEIRVEGVEDVLTNWENIKSKEKEEKGILSGIPKNMPALLTAFRIQEKASHVGFDWKNSKEILPKLYEEIKELEKAIQEDNKEKVEEEIGDLLFTVVNISRHLGIDPESSLRKTNNKFTERFNYIERKVKESGKDWKDYSLEELDELWEASKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2E8</accession>
    <name>B8E2E8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable glycine dehydrogenase (decarboxylating) subunit 2</fullName>
            <ecNumber evidence="4">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glycine cleavage system P-protein subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine decarboxylase subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine dehydrogenase (aminomethyl-transferring) subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gcvPB</name>
        <name evidence="5" type="ordered locus">Dtur_1518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvP family. C-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583868.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353406.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1518"/>
    <dbReference type="EnsemblBacteria" id="ACK42792">
        <property type="protein sequence ID" value="ACK42792"/>
        <property type="gene ID" value="Dtur_1518"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1518"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1567"/>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_0"/>
    <dbReference type="InParanoid" id="B8E2E8"/>
    <dbReference type="OMA" id="MHINLHK"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016594">
        <property type="term" value="F:glycine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00713">
        <property type="entry name" value="GcvPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023012">
        <property type="entry name" value="GcvPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="480" mass="54043" checksum="D3EA71952BEAF61D" modified="2009-03-03" version="1">MKKKIPLIKELSNDDRPNIHLPEPLEEFSPEKLLPKELLREDLPLPQLSEIEVVRHFTNLSSLGYGVDLGFYPLGSCTMKYNPKINEEIANNEYFTDLHPHTPEDLSQGALEIIYKLGEALSKITGMDKFTFQPSAGAHGELTALLMIKAYLKDKGEDRNIVLVPDSAHGTNPASASMAGFETIEIPSDERGLINPNILAKYLNKNVAVLMLTNPNTLGLFERDILKIAKMVHEEGALLYYDGANLNGIMGYARPGDMGFDAVHINLHKTFSTPHGGGGPGAGPVGVKDFLKDYLPIPTVEFNGEKYYLNYDIPKTIGRVRTFYGNFLVMVKAYAYIRLLGDEGLKRTTEMAVLNANYLKEKLKEYFNLPYPSICKHEFVLSGKRLKEKGVKVFDIAKRLLDYGIHPPTIYFPLIVEEALMIEPTETETKYTLEEFVDIIKTILKEIDENPEIVKNAPHNTPVKRLNEAYAAKMLKVNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2F4</accession>
    <name>B8E2F4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">xerC</name>
        <name evidence="13" type="ordered locus">Dtur_1524</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583874.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353412.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1524"/>
    <dbReference type="EnsemblBacteria" id="ACK42798">
        <property type="protein sequence ID" value="ACK42798"/>
        <property type="gene ID" value="Dtur_1524"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1524"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1573"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_0"/>
    <dbReference type="InParanoid" id="B8E2F4"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0229">DNA integration</keyword>
    <keyword evidence="7 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="12">
        <location>
            <begin position="3"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="11">
        <location>
            <begin position="107"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="300" mass="35641" checksum="93ECC5B9589D7669" modified="2009-03-03" version="1">MNLDLKREIENYINYLRFERNYSPNTLRSYLRDLLDFYKYCKEKDLDFTNKRNIRSYIQFIAQKGYKNSTFVRKVISLRSFFEYLLTFEKIKEDLTVFIPTPKIEKKLPQFLSIDEVRKLLNSPSLDNLIGIRDRAIIETLYATGIRVSELVGINEEDINWNYGEIRVFGKRAKERVVIVGEETLKILQLYKDYVRPKLLKKPEKAFFLNAKGGRISDRGVRMIIKKYTKEFNKKISPHTLRHTFATHLLEGGADLRYVQELLGHVRISTTQIYTHLTTDQIRRTYTVSHPRAIKKEREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2G1</accession>
    <name>B8E2G1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribonuclease HII</fullName>
            <shortName evidence="11">RNase HII</shortName>
            <ecNumber evidence="11">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rnhB</name>
        <name evidence="14" type="ordered locus">Dtur_1531</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 11 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="11"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583881.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353419.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1531"/>
    <dbReference type="EnsemblBacteria" id="ACK42805">
        <property type="protein sequence ID" value="ACK42805"/>
        <property type="gene ID" value="Dtur_1531"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1531"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1580"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_3_2_0"/>
    <dbReference type="InParanoid" id="B8E2G1"/>
    <dbReference type="OMA" id="YPTKLHL"/>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 11 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="26"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="203" mass="23021" checksum="973C7249A3A6D254" modified="2009-03-03" version="1">MASPKNRPRTLGERERELWYYFRYIAGVDEAGRGALAGPVYAGAVILPPLSSIPVNDSKLLSPKEREELFEIIKKEALCWSFGYATVEEIEELGILKATLLAMRRAIEKLEIKPEYLLVDGNIPIPNMDIPQETIVKGDRKCLSIASASIVAKVLRDRYMKELDKEYPGYGFSRHKGYATKEHREKIKSLGSLLIHRKGFKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2H9</accession>
    <name>B8E2H9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">recF</name>
        <name evidence="6" type="ordered locus">Dtur_1549</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583898.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353437.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1549"/>
    <dbReference type="EnsemblBacteria" id="ACK42823">
        <property type="protein sequence ID" value="ACK42823"/>
        <property type="gene ID" value="Dtur_1549"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1549"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1598"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2H9"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="SMC_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="359" mass="42862" checksum="3790F6F50A9D14D5" modified="2009-03-03" version="1">MRLIDLKVINFRNLKNLSLNFFDVNIFYGENAQGKTNILEGIYFLFSGKSFRTKNEKEIIRWGEESFYLKGNVDWQSQNLILETALSGEEKRIKINQKNLKRYRDMVFLFPIILFSQEEIENFKKGPSQRRYLLNRFISTLSYKYHKALSEYYKALYQRNLTLKNERDVSLWNSTLIRLGGYILFERRNVMEEIKRKVKEVSNNLLGRDFLEVEYLSSVPLGDSEEEMLKNFETMLKEKEWEEKRKKYTLVGPHRDDVILRVIRDNVKYDLRKFGSAGEKKLGYIIWKLAQVEILSENRKEKPILLIDDLFGDLDEDKQRKVWEGIKNFQIFLTTPIRIEFLKDFPHFLVKNGEVILNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2I0</accession>
    <name>B8E2I0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S4 domain protein YaaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583899.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353438.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1550"/>
    <dbReference type="EnsemblBacteria" id="ACK42824">
        <property type="protein sequence ID" value="ACK42824"/>
        <property type="gene ID" value="Dtur_1550"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1550"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1599"/>
    <dbReference type="eggNOG" id="COG2501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127162_4_0_0"/>
    <dbReference type="InParanoid" id="B8E2I0"/>
    <dbReference type="OMA" id="DQFLKWA"/>
    <dbReference type="OrthoDB" id="2071059at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014330">
        <property type="entry name" value="RNA-bd_S4-rel_YaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02988">
        <property type="entry name" value="YaaA_near_RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="71" mass="8090" checksum="1630E7B8D57A947B" modified="2009-03-03" version="1">MKEVKIYTEYITLGQFLKWCRIVETGGQAKNLILAGKVKVNGEIELHRSRKLKHGDVVEIDGEKYVVMVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2I7</accession>
    <name>B8E2I7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583906.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353445.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1557"/>
    <dbReference type="EnsemblBacteria" id="ACK42831">
        <property type="protein sequence ID" value="ACK42831"/>
        <property type="gene ID" value="Dtur_1557"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1557"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_7_4_0"/>
    <dbReference type="InParanoid" id="B8E2I7"/>
    <dbReference type="OMA" id="GMTHICE"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="105" mass="11867" checksum="8B1C8BC8ACD8F5CB" modified="2009-03-03" version="1">MSMENKKKLSMEECEALSDIFKSLSSYVRIHILCALSDGEKSAGEIAKIINASFANTSQNLKDLYNLGLLKKRRVGQFVYYSLADDSVLELLELVRKIRFKATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2M4</accession>
    <name>B8E2M4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583943.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353482.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1595"/>
    <dbReference type="EnsemblBacteria" id="ACK42868">
        <property type="protein sequence ID" value="ACK42868"/>
        <property type="gene ID" value="Dtur_1595"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1595"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591752_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2M4"/>
    <dbReference type="OMA" id="YATWAVV"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="440" mass="50385" checksum="FC505C18C498529C" modified="2009-03-03" version="1">MKKILLSIILISLFILTSVIPSFAQKVYTFKVGKYTFNIDTQKYRGKTIYVWQFWPEDDTALPGTRSPKQVREEFEKITGAKVKIVYTTWENYRPKLSAAILSGSGADVVYIGAGEKPTWMMKKMLLPLDRYIDFKDKNLWEAVGFRQSTLDFFKWRGQIYAVTNIYNDNVFPYILYYNKEKFEMAGLPDPLELYKQGKWTWETFFNLGKQLTQDINGDGKIDQYAYATWAVVQPFLYTNDVQVVKYVGGRPIFAMDDPKAYRAFQAIYEMDAKYKMRPADWWNDPQGRFQKGITCMDYWGPWELSGMRNALGKKLGIVPFPKGPDSKKKSADMADDGAWAIASSSSDPELSALYLLWMLTPTDKEKEIIVKSQIERVGGKEIYDLLLDAATRAQIDPISGIPGFWDLINQIDVANPAKSIKALKPKFQAAIEAILEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2M8</accession>
    <name>B8E2M8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zn-dependent hydrolase of the metallo-beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583947.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353486.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1599"/>
    <dbReference type="EnsemblBacteria" id="ACK42872">
        <property type="protein sequence ID" value="ACK42872"/>
        <property type="gene ID" value="Dtur_1599"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1599"/>
    <dbReference type="eggNOG" id="COG2220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_3_0_0"/>
    <dbReference type="InParanoid" id="B8E2M8"/>
    <dbReference type="OMA" id="CMNLPYT"/>
    <dbReference type="OrthoDB" id="767622at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002871082" evidence="1">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="243" mass="27814" checksum="DEB843D831CEF8D3" modified="2009-03-03" version="1">MKKIVLILSALTLLVSVALALEITYYGHACVKVSFENNYSIIIDPFSSDYPIPQTNADLIISTHEHEDHFNPNFLHKKVEILVGTKNDGKDWNPINKEVKNIKIWSIPVYHDNSKGSQRGKNSIVVIEGDGFKIVHMGDIGHLLSEKELVKLKNVDILFIPVGGFFTLDVKDVITTIREIKPKIVIPIHYKTEYTKDWPILPISEFLKRAEKEFKIITINSNRITLTPKDLPKNTEIWILNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2N6</accession>
    <name>B8E2N6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="5">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">queA</name>
        <name evidence="6" type="ordered locus">Dtur_1607</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583955.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353494.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1607"/>
    <dbReference type="EnsemblBacteria" id="ACK42880">
        <property type="protein sequence ID" value="ACK42880"/>
        <property type="gene ID" value="Dtur_1607"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1607"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1656"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2N6"/>
    <dbReference type="OMA" id="LSKHKMD"/>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002099">
        <property type="term" value="P:tRNA wobble guanine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="339" mass="38601" checksum="F2BE5AB74B5A50C2" modified="2009-03-03" version="1">MVLKLSDYDYYLPEELIAQEPAEPRDSSRLMLVNRRTGEIDITIFREIKNYLKSGDVLVLNNTKVIPARLYGKKDTGAKIEVLLLKKVEEGVYEALVKPGKRAKIGTKIYFSGDIYAEVVERKEEGIFVLRFSQEDLEEILPEIGNIPLPPYIKKPLNDPNKYQTVYAQKEGAVAAPTAGLHFTEELLHTLQKMGIEILYITLHVGLGTFRPVVVEDITKHKLDPEYFEVREDVAERINRAKEEGRRVIAVGTTVTRVLEAQGRSGRVEPGAGLVDLFIYPGFEFKILDGLITNFHLPKSTLLMLVAAFMGYDLMKKAYNRAIEERMRFYSFGDAMFIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Q4</accession>
    <name>B8E2Q4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583973.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353512.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1625"/>
    <dbReference type="EnsemblBacteria" id="ACK42898">
        <property type="protein sequence ID" value="ACK42898"/>
        <property type="gene ID" value="Dtur_1625"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1625"/>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_5_2_0"/>
    <dbReference type="InParanoid" id="B8E2Q4"/>
    <dbReference type="OMA" id="YRQYNLD"/>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="392" mass="45479" checksum="17361B999A8B3286" modified="2009-03-03" version="1">MVKIVITADNHLGKYYKKLLPEKLQERRKRLRDAFEEVVNFAIEEKVDIFVQAGDLFDSPNPRNQDLTFVAREFSKMTKNHIKIYAIGGNHDAPNMLESDSYPIRIFEEAGLIKTFSSQSTINYEIFEKDGLNILISGLSHDPRRKGRIDPIEKAIIPSDFPKENNLIKLLILHYSFEKFAHPKAQEPQVSIGTLDLLPFDIYIIGHLHEQNTYRFANKHVIIPGSTERFEFGEENLTPGFYLLTIENKKINYEHIKVKAQPMRNMEIRLTEIISENPTNSIIERIINNSHKDLLLKCKLIGEISLSLYRSINFNKILEAGINSNFLFDLDTQNLRIKGEEIHTLPAPETSVDKNLEMITKKYMEESPEDKDIIIEALNWLKEELKNREIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Q7</accession>
    <name>B8E2Q7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583976.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353515.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1628"/>
    <dbReference type="EnsemblBacteria" id="ACK42901">
        <property type="protein sequence ID" value="ACK42901"/>
        <property type="gene ID" value="Dtur_1628"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1628"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2081049_0_0_0"/>
    <dbReference type="OMA" id="EIRGCNI"/>
    <dbReference type="OrthoDB" id="2128779at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="117" mass="13453" checksum="BAB4AC624BFE917B" modified="2009-03-03" version="1">MYCKFSVRDEKLEDFKKGNFLIRFLKFQAPFKSDTEVHKKVNDIYIIYSGKAKVLLSDKYEGGKEIEPYEIRGCNILNPENVEMQSGDVLLISANTPHQLIVEEGSLNIIIVKIPEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2S7</accession>
    <name>DAPB_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="1">HTPA reductase</shortName>
            <ecNumber evidence="1">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapB</name>
        <name type="ordered locus">Dtur_1148</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583509.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353041.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2S7"/>
    <dbReference type="SMR" id="B8E2S7"/>
    <dbReference type="STRING" id="515635.Dtur_1148"/>
    <dbReference type="EnsemblBacteria" id="ACK42427">
        <property type="protein sequence ID" value="ACK42427"/>
        <property type="gene ID" value="Dtur_1148"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1148"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1185"/>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2S7"/>
    <dbReference type="OMA" id="HHPNKAD"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000117367" description="4-hydroxy-tetrahydrodipicolinate reductase">
        <location>
            <begin position="1"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="161"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="268" mass="29649" checksum="16A5EC0CCB92D43C" modified="2009-03-03" version="1">MIKTVLFGACGKMGKVIGKALIDATDIELVGAIDPYFKGEKYEKIIGIDKISLEVVESIDELQEDFDVAIDFTNAEAAYQNIKKVLQKGKRMVVGTTGLTQEMMEEFKDLAVKNKTAILIAPNFALGAVLMIQLAKQVVKYFPDVEIIELHHNEKADAPSGTAILTAEVLREEMKKYNLTHKDATKIEKLPGARGGKLDSINIHSVRLPGLVAHQEVIFGGLGQTLSIRHDALSRECYIPGVLMAVREIVKREGFFYGLESFLNREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2V4</accession>
    <name>B8E2V4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583536.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353068.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1175"/>
    <dbReference type="EnsemblBacteria" id="ACK42454">
        <property type="protein sequence ID" value="ACK42454"/>
        <property type="gene ID" value="Dtur_1175"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1175"/>
    <dbReference type="eggNOG" id="COG3156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1793412_0_0_0"/>
    <dbReference type="OMA" id="GLIIFWE"/>
    <dbReference type="OrthoDB" id="2133747at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="144" mass="16164" checksum="1C7D40445219176E" modified="2009-03-03" version="1">MNKGQILITVLLIIAMLSLIFSGLIIFWEGNISKVSAQIAEKQALYLAEGMAEMAIYSLIWFTGIPTYTTFGPITFSYTNFYGIAKSDFTYSPTESSFIITSNAIVTVIYTGQTYTYYRSLRLEGIRIGTSVPYSLTIINWVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2V6</accession>
    <name>B8E2V6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583538.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353070.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1177"/>
    <dbReference type="EnsemblBacteria" id="ACK42456">
        <property type="protein sequence ID" value="ACK42456"/>
        <property type="gene ID" value="Dtur_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1177"/>
    <dbReference type="eggNOG" id="COG3167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1493951_0_0_0"/>
    <dbReference type="OMA" id="NQFIDFF"/>
    <dbReference type="OrthoDB" id="2124337at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="180" mass="21458" checksum="2B8BB44F2DE3D4D0" modified="2009-03-03" version="1">MRNKIHLYIFTIVLLLGLILFVMPKYSQVSKKEREYNTKRLELENAIESIATLRDTLNKIEERRRVIFAERNLLFLREEEIPIFFKDLSIVIKRNKITSFEIKPSDFEEIQDLPENFPLKLKKLPINLKLIGNYNQFIDFFRDLYDESYPISFNQVQLMSSENLLTLNVIFDVYVLEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Z8</accession>
    <name>B8E2Z8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FecR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583580.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353112.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1219"/>
    <dbReference type="EnsemblBacteria" id="ACK42498">
        <property type="protein sequence ID" value="ACK42498"/>
        <property type="gene ID" value="Dtur_1219"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1219"/>
    <dbReference type="eggNOG" id="COG4254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_465207_0_0_0"/>
    <dbReference type="OMA" id="RITYPIM"/>
    <dbReference type="OrthoDB" id="1303919at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006860">
        <property type="entry name" value="FecR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04773">
        <property type="entry name" value="FecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870597" description="FecR domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="FecR" evidence="3">
        <location>
            <begin position="63"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="586" mass="66579" checksum="79714BFB2B27E95B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E320</accession>
    <name>B8E320_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ftsZ</name>
        <name evidence="8" type="ordered locus">Dtur_1242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583602.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353134.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1242"/>
    <dbReference type="EnsemblBacteria" id="ACK42520">
        <property type="protein sequence ID" value="ACK42520"/>
        <property type="gene ID" value="Dtur_1242"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1242"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1282"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_0"/>
    <dbReference type="InParanoid" id="B8E320"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="6">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="7">
        <location>
            <begin position="212"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="26"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="369" mass="39715" checksum="BA12936E0BE35D95" modified="2009-03-03" version="1">MFSLLSDNLDKFDEMRAKIKVIGVGGGGGNAVNRMIEAGIQGVEFIAINTDVQVLALNKAPHKVQIGEQVTQGLGAGGDPKIGEKAAIESRDIIKDILQDADMIFITAGMGGGTGTGASPVIAEIAKEIAKLVIAVVTLPFSFEGRKRRVNAMEGIEKLRNKVDTLLIIPNDKLLKIGDKNTPILESFKKADEVLKQAVQGITELITVPGLINLDFADIQSIMSRAGTAYMGIGIGKGENRAKEAAQNALHSPLLDFSINGAKGVIFNVTGGLDLSIHEVEEIAEVITPKVDPEANIKFGAVIDENMKDTIKVTLIATGFDHQEEVVSQEDSTKRKDYTSISEEDLDIPAILRRKRLIELEHKKGDNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E389</accession>
    <name>B8E389_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584038.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353577.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1691"/>
    <dbReference type="EnsemblBacteria" id="ACK42963">
        <property type="protein sequence ID" value="ACK42963"/>
        <property type="gene ID" value="Dtur_1691"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1691"/>
    <dbReference type="HOGENOM" id="CLU_2860509_0_0_0"/>
    <dbReference type="OMA" id="GLIIWWS"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="64" mass="7314" checksum="A42E81B7DDE3A6B2" modified="2009-03-03" version="1">MISKILIILFGLASIILGIWGLIIWWSYFVKALMAVVPIFLLFLGIILIIFGYSELKDQLSKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3A8</accession>
    <name>B8E3A8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584057.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353596.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42982">
        <property type="protein sequence ID" value="ACK42982"/>
        <property type="gene ID" value="Dtur_1710"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1710"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_1_0"/>
    <dbReference type="InParanoid" id="B8E3A8"/>
    <dbReference type="OMA" id="GWGRQFF"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="324" mass="37693" checksum="CB0C3269F40FD62F" modified="2009-03-03" version="1">MGKEFSFQWHITDFCNLRCKHCYQDIFDRSRELTYDRLIHIIQDISGFLKEQGFERLSINITGGEPLIYPYINPILKALDEIDIIDEINIITNGIIMPDIVLKGRYERLKYLKVSLEGAREETNDLIRGRGIFKRVIGNLKNTNYNFLLMFTLAKYNYRELDDMYRLSQNLGAKGFILERFIPLGEGSKIKDMVLNSKDWYQVVDRVATWADLTVEDLLPYKAFYIDFEENRILGALCNLGESCAVMPNGDVYPCRRFPLVLGNLSQESFSKIYPKILDFRANFTKDKLKGKCFLCAMEDCIGCRALSFSLFSDSFAEDYQCWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3E5</accession>
    <name>B8E3E5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxyglutaryl-CoA dehydratase D-component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584094.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353633.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1747"/>
    <dbReference type="EnsemblBacteria" id="ACK43019">
        <property type="protein sequence ID" value="ACK43019"/>
        <property type="gene ID" value="Dtur_1747"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1747"/>
    <dbReference type="eggNOG" id="COG1775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053697_1_1_0"/>
    <dbReference type="InParanoid" id="B8E3E5"/>
    <dbReference type="OMA" id="RICPYFQ"/>
    <dbReference type="OrthoDB" id="1815612at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="339" mass="39697" checksum="0FC78D0A29BCD74D" modified="2009-03-03" version="1">MEEIGEYFDYYSYLKDKINSGGYVGYMCSYVPPEIISASGFEPLPIIFPPLYPERTDEVYPKYFCPYIRNVNEYILRNGLNLEKIILTDGCDSSKRIYECWKELGVSNSIYFLRIPFNSDENSVKYFATELKELFKDLNGGIETEKLVKTIDFYNSLRDKIRRDGLNPLSIFSLLTGEAYTNFENNYDHNPQVKVYLLSSMFPLDFIKYLHSLGVEVAYIDSCFGGNLLERVENYHKDPFYVISEYYLKRTACVRSLGQEKRIENIKRLKENIDGVIIYTLKFCDPLIYQSARLREIIKTLNLPVLTIEDDYTLGNKGQIRTRVEAFVEMIYERRKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3F1</accession>
    <name>B8E3F1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase and metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584100.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353639.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1753"/>
    <dbReference type="EnsemblBacteria" id="ACK43025">
        <property type="protein sequence ID" value="ACK43025"/>
        <property type="gene ID" value="Dtur_1753"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1753"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010219_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3F1"/>
    <dbReference type="OMA" id="CKYSALD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="742"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="884"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="906"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1073" mass="123519" checksum="14C16160D30BB8A4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYG6</accession>
    <name>B8DYG6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphonopyruvate decarboxylase-related protein</fullName>
            <ecNumber evidence="6">5.4.2.-</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.-" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582434.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351962.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0007"/>
    <dbReference type="EnsemblBacteria" id="ACK41348">
        <property type="protein sequence ID" value="ACK41348"/>
        <property type="gene ID" value="Dtur_0007"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0007"/>
    <dbReference type="eggNOG" id="COG3635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034906_2_0_0"/>
    <dbReference type="InParanoid" id="B8DYG6"/>
    <dbReference type="OMA" id="IAFRCNF"/>
    <dbReference type="OrthoDB" id="1293048at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042253">
        <property type="entry name" value="Pglycerate_mutase_ApgM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="5">
        <location>
            <begin position="2"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="419" mass="45839" checksum="25D3B8357BE73122" modified="2009-03-03" version="1">MKKILYVVLDGLGGTSDPKLNGKTELEVAKTPNMDRLAQKAKLGLMYPIGPNIAPESDAAVLSILGYDVDKYYTGRGPLEAHGADIEVRDGDLAWRANFATVDEETLKILDRRAGRNLSTEEAKALAEEVNQKVKLEDAEFIFKATVGHRGVLVIRSKKGKLSANVENIDPGYKRHGPYSIAISNPPSEVQKCIPLDDSEEAKEAAKLTNEFVIKAFEVLKNSEINKKRKAEGKKPANIILLRDAGDSLPKVPTLQELYGLTFGSIVEMPVERGIALLTGMKEVPIEDATNYKLWADKVIYALEHYDGVYAHLKGPDVPGHDGDYDKKIKSIEDIDSIFFESLLPKLDFSKVVIAVTADHATPCMLKSHSEDPVPLMIITNGITPDGLTYFGESACSKGSIGKIKGTELLPLLVKIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYJ4</accession>
    <name>B8DYJ4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP:corrinoid adenosyltransferase BtuR/CobO/CobP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582462.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351990.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0038"/>
    <dbReference type="EnsemblBacteria" id="ACK41376">
        <property type="protein sequence ID" value="ACK41376"/>
        <property type="gene ID" value="Dtur_0038"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0038"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.39"/>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088595_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYJ4"/>
    <dbReference type="OMA" id="HAMGEGF"/>
    <dbReference type="OrthoDB" id="1690483at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="195" mass="22095" checksum="B7BBAC0B50B5539B" modified="2009-03-03" version="1">MSINKLSRGLIQVYTGDGKGKTTAALGQSIRAAGHGLKVLFVQFIKGNSFTGEFLFLKNSQNITFWQFGRDCVYSSGIRENIVECNNCYECFIGKEGPSEMDIKVVRGGWERVKSVIEDYDLIVLDEISLAIFYKIISAEEIIEFLKNKPEKLEIILTGRYMPEAIMDLADLITEMKEVRHPYSKGISARWGIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYN9</accession>
    <name>B8DYN9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0083</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582507.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352035.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0083"/>
    <dbReference type="EnsemblBacteria" id="ACK41421">
        <property type="protein sequence ID" value="ACK41421"/>
        <property type="gene ID" value="Dtur_0083"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0083"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.84"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYN9"/>
    <dbReference type="OMA" id="TFVVIQF"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="109"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="334" mass="38193" checksum="5A30FCE9EFCA4998" modified="2009-03-03" version="1">MSFIKRYLIPRLIQYVIVTFLGLTAIFLFPRLLPVDPIKQELVRYQTFGVYVSPEQQEQIMKTLRQLYGLEGTLWEQYLSFWGRLFKFDFGPSLSRFPTPVNKVIGMALPWTVGLLSFTTIIAWILAVIIGGIVGYYRKKWMEVFDFIIMIIRPIPYYITSLIFLILFAYIFPIFPLSGGIGIGTTLAFNLSTILNILKHAILPALTLIVVGFCWQFQSMKLITQVAKNEDHVIYAKIAGISDSKIVSNHVIRNAMLPMVTQLGLQFGTIFSGTLITEMVFAYPGIGWILYDSIMRADYNLIMGIMCISVIAVTTSILFLDLIYPLFDPRVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYP7</accession>
    <name>B8DYP7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582515.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352043.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0091"/>
    <dbReference type="EnsemblBacteria" id="ACK41429">
        <property type="protein sequence ID" value="ACK41429"/>
        <property type="gene ID" value="Dtur_0091"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0091"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003751_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYP7"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="96"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="277" mass="30872" checksum="DB13840BB7C21DD9" modified="2009-03-03" version="1">MDTLTTLSNVLILDYASLSSISKSFASTRVWAPIGFLVMMLTTGFYPKLTESTFMFPIISLVFLLCFLILLAIKELEFKVETKILTFNDVKRLISVKEVREFLLFMFFYSFALVGTSGNVNLLIKYLGGTNSDISWALVVCAAPEIPMSYFWGHMADKVGRKPLLLLAGLAMPIRSFLYFLTGRAFEVILIQFFTHIFTFVISINVAPIYVNDLVSPKERATGQGILNLSVALSQTLSSFISGNVANMVGLKGMYIFLAVIGLISAIWGLKIFRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYP8</accession>
    <name>B8DYP8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582516.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352044.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0092"/>
    <dbReference type="EnsemblBacteria" id="ACK41430">
        <property type="protein sequence ID" value="ACK41430"/>
        <property type="gene ID" value="Dtur_0092"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0092"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.95"/>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058393_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYP8"/>
    <dbReference type="OMA" id="KAWWHME"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="312"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="378" mass="42779" checksum="BBD4FEFDE4BCCE1F" modified="2009-03-03" version="1">MSSKVIVYNAEYEKESLKDKIKRALEYFDLPNFKGKRVFIKPNLLMASSPDKAITTHPTVIEAIIEILKEKEAREIFIGDTPGNTSTNLDHLYRVTGMKEVAERQKVNLVNLYTYGVVNIKSEVAGNIPLTKFIKEVDYIINVPKLKTHTFMLMTCTIKNTFGLVPGMNKSRMHAIAINPENFAKILVEIFSEVNPVINIVDAIVGMEGEGPSAGTPRKFGKIITGKDPVAVDVVSSLLLGYKPEEIYTNLIAYKKGLGEINIEKIEVIGEEKAKIYNHDVVKVKNFYSLSKNVPAFMGSITSFLYNKFIRQYPVIEDEKCIKCRICENSCPNKAITYDPNKMIIDYKKCISCFCCHELCPQKAIRLEKSLLARRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYR7</accession>
    <name>B8DYR7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="6">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mnmE</name>
        <name evidence="6" type="synonym">trmE</name>
        <name evidence="10" type="ordered locus">Dtur_0117</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="6">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582535.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352063.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0117"/>
    <dbReference type="EnsemblBacteria" id="ACK41449">
        <property type="protein sequence ID" value="ACK41449"/>
        <property type="gene ID" value="Dtur_0117"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0117"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.123"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_0"/>
    <dbReference type="InParanoid" id="B8DYR7"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="9">
        <location>
            <begin position="218"/>
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            <position position="21"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
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        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
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        <location>
            <begin position="228"/>
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        <ligand>
            <name>GTP</name>
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            <name>K(+)</name>
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            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
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            <dbReference type="ChEBI" id="CHEBI:57457"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="455" mass="51633" checksum="27A6E16EBCCCF5D6" modified="2009-03-03" version="1">MKDDIVAIATPLGFSAIGVIRLSGPNVINIVKRVFSPRRNKDLEKVSSHTLHYGNIIYKDEIIDEVLVAIYKAPNSYTGENMVEIFTHGSPIILEEILKILVEEGARIAERGEFTKRAFLNGKIDLLQAESINEIIRAESKTALKRALSKLKGEVSKSLRELKSKVEHLRIYLEASMDFPEDVEEREREDWLRRLEEIKREVSYLLEKAERGDWIKGGYRVILVGRPNVGKSSLFNALMKEDRAIVTPIPGTTRDYIEGELYLSSGHLVKIYDTAGLGIPKDILDKMGMEKTEKILEKSNLILFVVDGSGEISEEEINLFEKIRSYQNKEIILVINKVDLPQKVELSVFSEDIEKIFVSAKEGIGIEDLEKAIERHISSQELEDGIFLNVYHREKLKEIYQFCEEGISVLINLPQSLDILGDILYDMEKAFGEILGEEVSLDIADKIFANFCVGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYT4</accession>
    <name>ATPL_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit c</fullName>
            <shortName evidence="1">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpE</name>
        <name type="ordered locus">Dtur_0134</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582551.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352080.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DYT4"/>
    <dbReference type="SMR" id="B8DYT4"/>
    <dbReference type="STRING" id="515635.Dtur_0134"/>
    <dbReference type="EnsemblBacteria" id="ACK41466">
        <property type="protein sequence ID" value="ACK41466"/>
        <property type="gene ID" value="Dtur_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0134"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.139"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_2_0_0"/>
    <dbReference type="OMA" id="YCFVISM"/>
    <dbReference type="OrthoDB" id="1994978at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP_synth_F0_csu"/>
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        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
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        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
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        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000184359" description="ATP synthase subunit c">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <sequence length="85" mass="8954" checksum="95CAC5089D68670C" modified="2009-03-03" version="1">MLAWVIIASIITAGFSVALVGMNATKAQGNAAASAFESVARQPEAGDQINRMLLFALAFIETIMIFTLTVALILLFANPLLGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYT9</accession>
    <name>B8DYT9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved cytosolic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582556.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352085.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0139"/>
    <dbReference type="EnsemblBacteria" id="ACK41471">
        <property type="protein sequence ID" value="ACK41471"/>
        <property type="gene ID" value="Dtur_0139"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0139"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.144"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_1_0"/>
    <dbReference type="InParanoid" id="B8DYT9"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="OrthoDB" id="1498741at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="151" mass="17817" checksum="9BBA36732C162709" modified="2009-03-03" version="1">MLYERITKDYMSAMKNKDSFRAEVLSTLRSAIKYREIELREKGKELDDQEVLDVIKKEIKKRKEAIEMYKQGRREDLAEKEEKELAILQEYVPQGLSEEELKERIKSIIERVGARTMKDMGKVMKEAMAELRGFAEGEEIRRVVEELLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYV4</accession>
    <name>B8DYV4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582571.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352100.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0155"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41486">
        <property type="protein sequence ID" value="ACK41486"/>
        <property type="gene ID" value="Dtur_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0155"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.161"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045323_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYV4"/>
    <dbReference type="OMA" id="GPVINTY"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="298" mass="35133" checksum="C2DC85FEE1BFBC0A" modified="2009-03-03" version="1">MDISVVIPTYNRKKILEITLPNILNQDFEGEYEIIVSDDGSEDETSSYIKELQGKYKNLKYIKNNERKGPAYARNRAIEIAKGKLMVFIDSDIFVKKNFLKNHFEIQKKNNFNILVQGPVINTYNWEKPWEEKFKLRDISSAYFATGNASIPKEILLKAGFFDENFTFYGWEDLELGIRIKKLNIPKITSEKVTVWHIQTPPNLKNLPYLLNKEKERAKSALYFYKKHPILEVKMMIQLGKIYEIGNFIQRLFGLINEKNIDKWWEWAEKRGYHTLSQIFLSGVLNKVYLEELKRISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ16</accession>
    <name>B8DZ16_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582727.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352256.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0322"/>
    <dbReference type="EnsemblBacteria" id="ACK41642">
        <property type="protein sequence ID" value="ACK41642"/>
        <property type="gene ID" value="Dtur_0322"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0322"/>
    <dbReference type="eggNOG" id="ENOG502ZBGR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072734_0_0_0"/>
    <dbReference type="OMA" id="IPVSCTE"/>
    <dbReference type="OrthoDB" id="1303616at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="279" mass="32448" checksum="7D91182046304AEF" modified="2009-03-03" version="1">MKIDKIFSSLEIMDPQTFDNITIFPLKLEIDNMPYFINLDSALKTGKFLIKEVNAFGEVPVLKVINTLSEQVLILDGEELKGGKQNRVVNTSILVKKNSELTIPVSCTEAHRWDYTSEGFKDSDVIIPMEIRKEKNETVLQNLISKGEFRSDQVSIWNMIDLYKRAYNVDSATSAMRDIYEKEKDNLENKIRNFTYTEGQNGILVYINGGFEGMDIIPLVSAYKNLHEKLIRSCIFRYPYKKYYEVKEVNKRIFEEISKIEPLKFKWVGLGWDLLKENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ48</accession>
    <name>B8DZ48_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582759.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352288.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0370"/>
    <dbReference type="EnsemblBacteria" id="ACK41674">
        <property type="protein sequence ID" value="ACK41674"/>
        <property type="gene ID" value="Dtur_0370"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0370"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.389"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_4_2_0"/>
    <dbReference type="InParanoid" id="B8DZ48"/>
    <dbReference type="OMA" id="DDQFVTI"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="139"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="416" mass="47856" checksum="412816A7A5BADBFA" modified="2009-03-03" version="1">MRPVEVIMIGAGNRGYEAYGKIILRRPDIKVVAVAEPNDIRRERFAKEHHIPSERQFKTWEEVFEKEKFADGVIITTMDRMHVKPAIEAIKRGYKILLEKPIGVNLEEIKELYKVAKEYNASITVAHVLRYTMFFQKLKELLNKQEIGELIGINLVENIGFFHFAHSFVRGNWRNSETSAPSILAKSCHDLDILTFLIGEKSQTISSFGELRYFKRENAPKEAKERCLDCSVDCPYDAKKIYLGDYTGWPVSVISEDLSLEGRLKALREGPYGRCVYYSDNNVVDHQEVSIKFKNNVYASFTMTAFTNKITRKIYLYGSHGEIYGDLDENKIYIQKFGKEEEIINLNLPFKDLVGHAGGDEGIMEEFVKALKGEIKETLSNIEESIESHLMAFSAEESRLNNKVINMDEVRAKFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ71</accession>
    <name>B8DZ71_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulf_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0511</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582889.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352418.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0511"/>
    <dbReference type="EnsemblBacteria" id="ACK41804">
        <property type="protein sequence ID" value="ACK41804"/>
        <property type="gene ID" value="Dtur_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0511"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050656_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZ71"/>
    <dbReference type="OMA" id="SLHGWLW"/>
    <dbReference type="OrthoDB" id="1899767at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="18"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="330" mass="35216" checksum="D6EB9950843379D5" modified="2009-03-03" version="1">MIWQGLIVGILFGVVLQRSRMCFNSAIRDIKFNKDNYLAKMAAVAILLETLGFHLVASLGWIKLNPLPFIPLAQIIGGFLFGMGMVLAGGCASGVTYRIGEGYITAILAGLSFGVTAAAVRGGVLNFVNSWFGSPITVTMQDPGIYNAVEGKVSPTIANVFGINPWIVAIIFAILLAVYIWGTKTTERQVSGLNWLTGGIALGVVGILGYLSQKTYALGITGGWVNLLKGTVAGVPYNWIGMEVLGIIIGAFISAVASKEFKLRVPKDPKTYLQVILGGILMGFGAGVAAGCNIGHILSGLPHLALSSILATIFFVLGNWFMYWYLYARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ87</accession>
    <name>B8DZ87_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0527</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582905.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352434.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0527"/>
    <dbReference type="EnsemblBacteria" id="ACK41820">
        <property type="protein sequence ID" value="ACK41820"/>
        <property type="gene ID" value="Dtur_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0527"/>
    <dbReference type="eggNOG" id="COG2445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZ87"/>
    <dbReference type="OMA" id="NYKECIA"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="133" mass="15598" checksum="8430D597769E5827" modified="2009-03-03" version="1">MIVKDRVKKLEEIINTLEELKNRFSLEDIKRNKITQWALKYGIYLCITGIGEIACGIIDERKLGNAKNYKECIALLGDNNILDKSSVEKLISYINIREMLKRSYIDVDLEKLYLLTEKLDFFKDLISKFKNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZA8</accession>
    <name>B8DZA8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sucrose-6-phosphate hydrolase</fullName>
            <ecNumber evidence="4">3.2.1.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Invertase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Enables the bacterium to metabolize sucrose as a sole carbon source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Glycan biosynthesis; sucrose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582926.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352455.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0551"/>
    <dbReference type="CAZy" id="GH32">
        <property type="family name" value="Glycoside Hydrolase Family 32"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41841">
        <property type="protein sequence ID" value="ACK41841"/>
        <property type="gene ID" value="Dtur_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0551"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001528_7_0_0"/>
    <dbReference type="InParanoid" id="B8DZA8"/>
    <dbReference type="OMA" id="WMGVPDG"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="UniPathway" id="UPA00238"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006232">
        <property type="entry name" value="Suc6P_hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01322">
        <property type="entry name" value="scrB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="6">
        <location>
            <begin position="42"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_32C" evidence="7">
        <location>
            <begin position="348"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="499" mass="58553" checksum="0123C2864B41CB35" modified="2009-03-03" version="1">MAFERSFKKVDKKNAYSQLEKANLFVKEHKKYVNPKYRLVYHLMGEYGWINDPNGFIYFNGIYHCFYQHNPFNSCWGPTYWGHAISEDLVKWQYLPIALAPDSEYDKDGCFSGSAIEKDGKIYILYTGHVKKSDEEYMQTQCLAWSNDTINFIKYEGNPVIGLDKIPGGASKKDFRDPKVFKRGDKYYVLVASKDLNGKGQILFYESHNLIDWNFVNILFKSDIDREHILECPDFFSIDNKDVLIFSIQYIENNKVIRSETRYCTGLIDWNKGVFNLEYCDLIDYGTHFYAPQTTLGKNGCRVMIAWMDVWEREFPTHKLGHNWAGALILPREIYLKGNKLFFRPIKEIEKYRKNEQIFEGVLEGEHIRLPLEDNCFELDMTAEFFVDTEMNLELLSREDSGNDLIKLTFKYSFGVLELTVTIRDSVNNNENQSLLIDSLSSRLNLRLFMDKSSLEMFINEGEKVITKRVYPFKKYDLINISSQNACKVRLKKWNLQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZD2</accession>
    <name>B8DZD2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582950.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352479.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0576"/>
    <dbReference type="EnsemblBacteria" id="ACK41865">
        <property type="protein sequence ID" value="ACK41865"/>
        <property type="gene ID" value="Dtur_0576"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0576"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.612"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_2_0"/>
    <dbReference type="InParanoid" id="B8DZD2"/>
    <dbReference type="OMA" id="VDHTYLF"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="133"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="315" mass="36288" checksum="D6C2041991F1824A" modified="2009-03-03" version="1">MDKFIGLIGLGYWGKNILRNLYELNVLRSACDFDKRVIEERRKDFPDVNYTQKIEDILQDQEITAVVIATPAVTHYDLAKRAILSGKDVFVEKPMTVSLKEGEDLVKLAEERGKILMVGHILKYHPAVVKMEEMVKRGDLGDIMYIYSHRLNVGKVRTDENAWWSLAPHDISLILELTGGMPVKVYSQGFGFITKGIEDGVLAALEFESGIKAHIFVSWWHPFKEQRLVVIGKKGMIVFDDNTREKLFLYPHKVEYNNGFPMPKKEEMQIIPVENEEPLKLELLHFIECVKERKRPKTDGYEGLRVLKILEQVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZK7</accession>
    <name>B8DZK7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine exporter protein (LYSE/YGGA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583025.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352554.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0655"/>
    <dbReference type="EnsemblBacteria" id="ACK41940">
        <property type="protein sequence ID" value="ACK41940"/>
        <property type="gene ID" value="Dtur_0655"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0655"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104651_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZK7"/>
    <dbReference type="OMA" id="NPYFWIW"/>
    <dbReference type="OrthoDB" id="1440181at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="209" mass="23580" checksum="4F28BBC87B1BB9C3" modified="2009-03-03" version="1">MSLGIWGIFITSFLVGFSGASSPGPMLTMVLTQSSIKGWFESVKIVTGHAILEGILVILLLLGLQPFLQNQVFLKIFSFLGSLFLLYMGIGLFVSLLKNNIHIKNASSLKIPSILGGILVSFSNPYWLMWWITIGVSFLTQAKDYLIFGVLSFYFGHILSDYVWYAFIGLIGQGLSLPFWKRIYKVILYFASVFLIFFGIYFMRYVFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZP7</accession>
    <name>B8DZP7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="13" type="ordered locus">Dtur_0695</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583065.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352594.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0695"/>
    <dbReference type="EnsemblBacteria" id="ACK41980">
        <property type="protein sequence ID" value="ACK41980"/>
        <property type="gene ID" value="Dtur_0695"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0695"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.733"/>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_0"/>
    <dbReference type="OMA" id="HGMKSYF"/>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="58"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK41980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="401" mass="44280" checksum="D4BE36D8E087A77E" modified="2009-03-03" version="1">MRKIDFKNLPDERGYFGEFGGRFVPETLMEPLLQLEEAYNKYKDDEEFKKELGYYLKTYVGRPTPLYFAKNLSERLNAKIYLKREDLCHTGAHKINNAVGQALLAKYMGKRRLIAETGAGQHGVATATVAALFGFQCTVYMGEEDCERQKINVLRMKLLGAEVVPVKVGSRTLKEAINEALRDWVAHPEDSYYLLGSVVGPHPYPIIVRDFQKIIGEEAKNQILEIEGRLPDYLIASVGGGSNSIGLFYPFLEEDVKIIGVEGGGKGLGSGLHSASINFGKVGVLHGAKMYLIQDENGNVSPTHSISAGLDYPGVGPEHSFLAQIGRVKYDIATDDVALKGFLTLSELEGIIPALESAHAIGYVIEHRKDFPEEEPIIIINLSGRGDKDLGIIINYMGEKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZP8</accession>
    <name>TRPA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="1">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpA</name>
        <name type="ordered locus">Dtur_0696</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583066.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352595.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZP8"/>
    <dbReference type="SMR" id="B8DZP8"/>
    <dbReference type="STRING" id="515635.Dtur_0696"/>
    <dbReference type="EnsemblBacteria" id="ACK41981">
        <property type="protein sequence ID" value="ACK41981"/>
        <property type="gene ID" value="Dtur_0696"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0696"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.734"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZP8"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="OrthoDB" id="912786at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_1000117735" description="Tryptophan synthase alpha chain">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <sequence length="253" mass="28793" checksum="BA27A243BDE23183" modified="2009-03-03" version="1">MSNLLEKFKNKSKSLFFIPFFVSGFPSFDFLEVFLLKNKDKIDILELGVPFSDPVADGPVLQEINYRAMVRGVNLNSTLDWLVRSGVSRNIDVILLLYFNLIQNKLEENLKRFKDTEIKGLVIPDLPMEEAETLIPLFNKYNLDLILFISPTTRDERMKKILKMAPSFLYCISVKGVTGERDKLPEEGVSFISRIKKETDKPLVWGFGLSNSSQIAALKGLVDGVIVGSAIGKRLLNNEDIQEYFDELYRATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZQ1</accession>
    <name>B8DZQ1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aminotransferase class I and II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583069.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352598.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0699"/>
    <dbReference type="EnsemblBacteria" id="ACK41984">
        <property type="protein sequence ID" value="ACK41984"/>
        <property type="gene ID" value="Dtur_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0699"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_0"/>
    <dbReference type="InParanoid" id="B8DZQ1"/>
    <dbReference type="OMA" id="YPYFRPI"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="46"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="396" mass="43870" checksum="7EEAD9AB7CA2739C" modified="2009-03-03" version="1">MDLFDKIKKVEYLQEARIAIDQGIYPFFLPLEETEGTEVVINGRRLIMLGSNNYLGLTTHPKVKEAAIKAIKEYGTSCTGSRFMNGTLKLHKKLEEKLAEFLHKEAALVFSTGYQTNLGTISALIGKGDIAITDKEDHASIIDGCRLSQGEMKRFKHNDMEDLEKVLASCSDNAGKLVIVDGVFSMAGDIAPLPEIVKLCEKYGARLMVDDAHSIGVLGDHGRGTANHFGLEDKVDIIMGTFSKSFASLGGFIAGDEDVIFYIQHTARSFIFSASMSPANTAAALAALEVMQEEPERIDHLWKIANRMREGLKSLGFDIGNSCTPIIPIYIRDRWKTIYMWKELFDLGVYCNPVLPPGVPPNQSLLRTSYMATHTEEQIDRALEIFEKAGKKVGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZR1</accession>
    <name>B8DZR1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4352 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583079.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352608.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0709"/>
    <dbReference type="EnsemblBacteria" id="ACK41994">
        <property type="protein sequence ID" value="ACK41994"/>
        <property type="gene ID" value="Dtur_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0709"/>
    <dbReference type="HOGENOM" id="CLU_1624512_0_0_0"/>
    <dbReference type="OrthoDB" id="2120900at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029051">
        <property type="entry name" value="DUF4352"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029050">
        <property type="entry name" value="Immunoprotect_excell_Ig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11611">
        <property type="entry name" value="DUF4352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="DUF4352" evidence="2">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="163" mass="19035" checksum="F21603EFED3CF857" modified="2009-03-03" version="1">MRKGVILIIIWLLFFSLSFGETTPLIIQGKEVKGENLDGLIVYILKVQKIEELPLYLDFKYLPEGIFYMVNLFIWNKTEKEILLTHNNFSLIDDDGRKNPVSTFASVYYALRDYNVFFKKYIKPGELMEGYLIFEINKSNTPYKLNIVDIPEKGKSYTVSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZV3</accession>
    <name>B8DZV3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Quinolinate synthase</fullName>
            <ecNumber evidence="2 9">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nadA</name>
        <name evidence="10" type="ordered locus">Dtur_0754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="2 9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583121.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352650.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0754"/>
    <dbReference type="EnsemblBacteria" id="ACK42036">
        <property type="protein sequence ID" value="ACK42036"/>
        <property type="gene ID" value="Dtur_0754"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0754"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.792"/>
    <dbReference type="eggNOG" id="COG0379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047382_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZV3"/>
    <dbReference type="OMA" id="CFCSTMN"/>
    <dbReference type="OrthoDB" id="613347at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034628">
        <property type="term" value="P:'de novo' NAD biosynthetic process from aspartate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Iminoaspartate binding" evidence="9">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="298" mass="33806" checksum="65369FF0950D40ED" modified="2009-03-03" version="1">MTIQEKIQKLKKEKNAIILAHNYQLPEVQDIADFVGDSLELARISAQVKEEVIIFCGVHFMAETASILAPDKKVILPDLFAGCPLANTITPREVKELKEKYPNYAVVAYVNTSAEVKAESDYICTSANATFIVEKIPEEKVIFIPDRNLGYYVSKHTKKEIIIWNGFCPTHQRILPQDIIALKEKYKDAKVVVHPECRKEVLDLADKIASTSGIIKFVKEDNGKRYIIGTEVGLLHRLRKENPEKEFYLASPLAICPNMKKITLDKILTSLENLEPEVKVEESTREKAIKPIERMLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZV4</accession>
    <name>B8DZV4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LapA_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583122.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352651.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0755"/>
    <dbReference type="EnsemblBacteria" id="ACK42037">
        <property type="protein sequence ID" value="ACK42037"/>
        <property type="gene ID" value="Dtur_0755"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0755"/>
    <dbReference type="eggNOG" id="COG5416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142842_3_0_0"/>
    <dbReference type="InParanoid" id="B8DZV4"/>
    <dbReference type="OMA" id="TIYFLNW"/>
    <dbReference type="OrthoDB" id="2161297at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010445">
        <property type="entry name" value="LapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06305">
        <property type="entry name" value="LapA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="LapA_dom" evidence="6">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="95" mass="10797" checksum="36E6CE6D83AC9280" modified="2009-03-03" version="1">MSTIIIVLLIGVIIALLLSFQNQALITIYFLNWSFQEKIFTVLFLTFASGVILAFISVLPTIIKDKRTIAKLNKKIKELEKSINKENIPEQSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZV6</accession>
    <name>B8DZV6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583124.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352653.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0757"/>
    <dbReference type="EnsemblBacteria" id="ACK42039">
        <property type="protein sequence ID" value="ACK42039"/>
        <property type="gene ID" value="Dtur_0757"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0757"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.795"/>
    <dbReference type="eggNOG" id="ENOG502Z85H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_438493_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZV6"/>
    <dbReference type="OMA" id="GKSEMCQ"/>
    <dbReference type="OrthoDB" id="236359at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032583">
        <property type="entry name" value="DUF4914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16260">
        <property type="entry name" value="DUF4914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="626" mass="70894" checksum="AB1C45E102CE2B14" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZW0</accession>
    <name>B8DZW0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583128.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352657.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0761"/>
    <dbReference type="EnsemblBacteria" id="ACK42043">
        <property type="protein sequence ID" value="ACK42043"/>
        <property type="gene ID" value="Dtur_0761"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0761"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.799"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_0_0"/>
    <dbReference type="InParanoid" id="B8DZW0"/>
    <dbReference type="OMA" id="VPEQLHH"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="283" mass="32348" checksum="F681169B6E235351" modified="2009-03-03" version="1">MIQKRPYGKNRELLSIIGFGGILVMNEEQKEANRRVAEAIDLGINYFDVAPSYGDAEDKLGPALRGKRKDIFLACKTMERIKDKAWEELQRSLKKLETDHFDLYQLHAMTTEEDFQLVTGPNGALEAFIKAKKDGIIRYIGFSAHSVEVALKLLEIFDFDSILFPINWVNFFNGNFGPQVVKKAQEKNVTILALKAMAKTIIPEGQERRYPKCWYDPIDDKELAQLALRFTLSQPITAAIPPGEYKFFKWAVEVGENFKPLTDEELNILKQKAQDLEPIFKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZY3</accession>
    <name>B8DZY3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DegV family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583151.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352680.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0785"/>
    <dbReference type="EnsemblBacteria" id="ACK42066">
        <property type="protein sequence ID" value="ACK42066"/>
        <property type="gene ID" value="Dtur_0785"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0785"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.824"/>
    <dbReference type="eggNOG" id="COG1307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048251_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZY3"/>
    <dbReference type="OMA" id="HCENEAD"/>
    <dbReference type="OrthoDB" id="1288126at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003797">
        <property type="entry name" value="DegV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043168">
        <property type="entry name" value="DegV_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02645">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00762">
        <property type="entry name" value="DegV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51482">
        <property type="entry name" value="DEGV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="283" mass="31679" checksum="BDEFE2F970712214" modified="2009-03-03" version="1">MIKIVTDSTAALPKEYVEKYDVTVVPLKVAFGDEVYRDGVDITPEIFFKKVKESTVFPKTSQPSVEEFYQAYQNIFEKHPDTEAIISIHISAKLSGTVGSANAAREIHPQKDKIFVVDSKLTELALGVVVIELAKAIEKGAKVDDLINLAEKLYLNSNIKFTVDTLEYLYRGGRIGAAQAWMGSILQIKPILELREGAIEPVERVRTKQKLRARIIELIKEYAGKDPVKIAVAYSDNYEEVLEISQEVKNTLNITDFYMGFFSCTILSHIGPGSWGIIAFKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZZ0</accession>
    <name>B8DZZ0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAA ATPase central domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583158.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352687.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0792"/>
    <dbReference type="EnsemblBacteria" id="ACK42073">
        <property type="protein sequence ID" value="ACK42073"/>
        <property type="gene ID" value="Dtur_0792"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0792"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.831"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_0"/>
    <dbReference type="InParanoid" id="B8DZZ0"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="977094at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="50"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="431" mass="49243" checksum="808EF6E0890F08E8" modified="2009-03-03" version="1">MDKQERLFKEDNSYEPLSFRMRPRTLEEFLGAEDIIGEKSFLRKAINKGYLPSLIIYGPPGSGKTTLSVLLAKAINAEFIELNAAIVGVQELKEALQKAKRNLELYNKRTVLFLDEIHHFNKLQQDVLLPFVERGIMILIGATTENPFFSLNTTLLSRCRLVELKPLSKENIERIIKRALEDKERGLGERDLEINEDAMEEIVRFANGDARIALNTLELASFMVAPSENGKLIITRNIVKEVIGKRIFRYDQRGDEHYHTISAFIKSIRGSDPDAALYYLAKMLLSGEDPRFIARRLIIHAAEDIGMADPFALVIAQSAYYAVDVVGMPEARIPLAEATVYLATAPKSNSIIIGIDKAMRYIEEHGISVIPEHLRGNSPKYIYPHDYPDHFVKQKYLPEDIGEIFYSPSDQGKEKMIRERLENLWKERYKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E009</accession>
    <name>UPP_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">upp</name>
        <name type="ordered locus">Dtur_0811</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583176.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352706.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E009"/>
    <dbReference type="SMR" id="B8E009"/>
    <dbReference type="STRING" id="515635.Dtur_0811"/>
    <dbReference type="EnsemblBacteria" id="ACK42092">
        <property type="protein sequence ID" value="ACK42092"/>
        <property type="gene ID" value="Dtur_0811"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0811"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.849"/>
    <dbReference type="eggNOG" id="COG0035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067096_2_2_0"/>
    <dbReference type="InParanoid" id="B8E009"/>
    <dbReference type="OMA" id="TYATRMP"/>
    <dbReference type="OrthoDB" id="1581906at2"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000139116" description="Uracil phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <sequence length="207" mass="22686" checksum="0CCFB755C88D7BB6" modified="2009-03-03" version="1">MVIVVDHPLVQHKLTKLRDKSTEPKEFRELLSEISSLMLYEVTRNLPTKEVEVETPLGIAKGKVLNNKDLAIVPILRAGLVMAEGMLRILPSAKVGHIGLYRDPNTLKPVQYYTKLPEDIDKREVVVVDPMLATGGSAIAAISILKTKGVKNIKFVCIISAPEGIEALKNSHPDVDIYTAAIDEKLNDHGYIIPGLGDAGDRLFGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>B8E030</accession>
    <name>B8E030_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation elongation factor G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583197.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352727.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0832"/>
    <dbReference type="EnsemblBacteria" id="ACK42113">
        <property type="protein sequence ID" value="ACK42113"/>
        <property type="gene ID" value="Dtur_0832"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0832"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.871"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_0"/>
    <dbReference type="InParanoid" id="B8E030"/>
    <dbReference type="OMA" id="KPKIAYR"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="6"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="695" mass="77008" checksum="7DD17B79F8E38FDC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E032</accession>
    <name>PROB_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl kinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proB</name>
        <name type="ordered locus">Dtur_0834</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583199.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352729.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E032"/>
    <dbReference type="SMR" id="B8E032"/>
    <dbReference type="STRING" id="515635.Dtur_0834"/>
    <dbReference type="EnsemblBacteria" id="ACK42115">
        <property type="protein sequence ID" value="ACK42115"/>
        <property type="gene ID" value="Dtur_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0834"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.873"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_2_0_0"/>
    <dbReference type="InParanoid" id="B8E032"/>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="OrthoDB" id="1480250at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006561">
        <property type="term" value="P:proline biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000125227" description="Glutamate 5-kinase">
        <location>
            <begin position="1"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="274"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="208"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <sequence length="371" mass="41319" checksum="0BF754F7BA8D0E77" modified="2009-03-03" version="1">MNNWKRIVVKVGTSSITDGRGSPSGEKILSLVKECVKLIRADKELVLVSSGAIASGREIIQKLSKRKDLPAKQALSAVGQVRLMQYYSQLFSIFKQPIAQILLTAEDLRDRKRYINISQTFETLLEEKIIPIVNENDTVAVEEIKIGDNDTLSAKVACAINADLLVILSDVEGLYSEDPNISSNALLITDVYEIDESIEKIAGPGKGTGGMFTKVQAAKIVTEAGIPMILARADVENILERIVLKKEKVGTFFYPSEKHLNKRKHWMLFMAKPEGRIYIDDGAKDALLKRGKSLLPVGIKKVEGEFTRGDTVSIFDLRGEEIARGITNYDSLELDKIKGKNTEEIRNILGEDFYEEVIHRNNLVLTNRGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E035</accession>
    <name>B8E035_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583202.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352732.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0837"/>
    <dbReference type="EnsemblBacteria" id="ACK42118">
        <property type="protein sequence ID" value="ACK42118"/>
        <property type="gene ID" value="Dtur_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0837"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.876"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791604_0_0_0"/>
    <dbReference type="InParanoid" id="B8E035"/>
    <dbReference type="OMA" id="DNDYTPR"/>
    <dbReference type="OrthoDB" id="1228289at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990281">
        <property type="term" value="C:efflux pump complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="239"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="342" mass="39001" checksum="334F3A376FC7C220" modified="2009-03-03" version="1">MRRLFIIFVSFVLLLSISFSQEAKVLSLEEAIDIALKNNGDLLVAKINLDNAFVDYENKKKDPTTLILALKQAELNLSLEKVRYENTKLQVIQNVRNAYFNVLEAQTQVKLYEKQLAYYEETFNATKAKYQVGNATATDVSQAELNYLSAVNSLKTAQNNLTIYWSQFWQTLGISPIEKVVLREPEMKVYNFNLDDLFNIAKENLSSLVQAKNNVELYELQVKLCDNDYTPKATLISAMNSLESAKKSYEQTLNSTKITIAQRLEQLNASLKDIEVQQKNLDLAKENYKIIQLKLDAGLVTKLDLMNAEINVIKAENNYYSSLHNYWKSLDSLSLAVGKALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E043</accession>
    <name>B8E043_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MucB_RseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583210.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352740.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0845"/>
    <dbReference type="EnsemblBacteria" id="ACK42126">
        <property type="protein sequence ID" value="ACK42126"/>
        <property type="gene ID" value="Dtur_0845"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0845"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_841279_0_0_0"/>
    <dbReference type="InParanoid" id="B8E043"/>
    <dbReference type="OMA" id="LWKSISW"/>
    <dbReference type="OrthoDB" id="963283at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033434">
        <property type="entry name" value="MucB/RseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03888">
        <property type="entry name" value="MucB_RseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MucB_RseB" evidence="1">
        <location>
            <begin position="113"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="330" mass="38423" checksum="BF68952C1D7FAB9A" modified="2009-03-03" version="1">MNKILSTTLVVLFFIPIFAIDPMEIIKNYGLNSGKISYEGIEVSILFDNPDFPKTSMAKVIANGKYMVRRDFLSPPFMLGRINIDDGKFQYDFDPKKNLVKISPSSTIFLNKDEINKRLNLIKKNFSTKLEREEVYLGRKVYVLTISSVYTKKVVLRLWIDKDKYIPLRIDKYNSDGVLIGRIMFVEIGFNPKLQNDLFDSNILKDKNVKMEETKLREEKLENASVPSELSLGYSLIKYYTIWERDDKFTHYFKYTDGLNDASLFKGLMPFKLPGKPTDIDNFHVFYDSNVLWKSISWVDGDNFYLLIGDFPKDYLSKIISTFIKDPVVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E089</accession>
    <name>MRAZ_DICTD</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraZ</name>
        <name type="ordered locus">Dtur_1256</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583616.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353148.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E089"/>
    <dbReference type="SMR" id="B8E089"/>
    <dbReference type="STRING" id="515635.Dtur_1256"/>
    <dbReference type="PRIDE" id="B8E089"/>
    <dbReference type="EnsemblBacteria" id="ACK42534">
        <property type="protein sequence ID" value="ACK42534"/>
        <property type="gene ID" value="Dtur_1256"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1256"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1296"/>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107907_0_5_0"/>
    <dbReference type="InParanoid" id="B8E089"/>
    <dbReference type="OMA" id="RGQERCL"/>
    <dbReference type="OrthoDB" id="1684767at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000143">
        <property type="term" value="P:negative regulation of DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000134788" description="Transcriptional regulator MraZ">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 2" evidence="2">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <sequence length="146" mass="17460" checksum="2FD288D403E6DFDC" modified="2009-03-03" version="1">MFVGEYYHSLDEKGRLIVPNNFRQLLGETFYLTRGFERCLNIYTITDWNNFSEIISSFSPTDDLMRRLCRFWFSGSVQVTTDKLGRILIPSFLIDYAELYKDVVIIGAGRHIEIWAKERWEEFNKEENILESMKEINEKVSELWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0A2</accession>
    <name>B8E0A2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParB domain protein nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583629.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353161.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1269"/>
    <dbReference type="EnsemblBacteria" id="ACK42547">
        <property type="protein sequence ID" value="ACK42547"/>
        <property type="gene ID" value="Dtur_1269"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1269"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061968_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0A2"/>
    <dbReference type="OMA" id="HIRTRQY"/>
    <dbReference type="OrthoDB" id="821590at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025111">
        <property type="entry name" value="DUF4032"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13224">
        <property type="entry name" value="DUF4032"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="34"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="262" mass="31213" checksum="1291A18FCBA7D019" modified="2009-03-03" version="1">MRFFRGLFKKRHLKSFDEKLKEEDFIGWRDLGYQTIEVDKIVGSVGRYRDFDEEFRPLKGSSKSRLQELENAILRGKILPPIEVYKIKDEYYVVDGNHRVAVAKKLGQKEIDAHIIEYIPAETSMENILARERSDFELITGLRDIILTEIGQYRKLLSQILEHKYYMSERRGEEVSIKEAARDWYKNIYLPIVEKIRKEKLLDAFPGRTESDLYVYISDHKWLESQKRGYDIGFDKAIEDFKNFVPETSLKEKIFDLFKFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0B0</accession>
    <name>B8E0B0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactoylglutathione lyase or related lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583637.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353169.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1277"/>
    <dbReference type="EnsemblBacteria" id="ACK42555">
        <property type="protein sequence ID" value="ACK42555"/>
        <property type="gene ID" value="Dtur_1277"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1277"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1317"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_3_1_0"/>
    <dbReference type="InParanoid" id="B8E0B0"/>
    <dbReference type="OMA" id="GRYAYMD"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="10"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="151" mass="17498" checksum="7E817BD5B898B51E" modified="2009-03-03" version="1">MSNEILGTDMVVQIGIIVKDIEKAVEEFSRIFNVVKPEIIITDVYEKAHTEYKGKPTSARAKLAFFKNFKNVEIEFIEPDENPSTWREFLDKHGEGVHHLAFLVKGTDEIVRRFKNYGIEVAQKGDYTGGKYTYLDSFEKLKFIIELLENF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0B2</accession>
    <name>OBG_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Obg</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">obg</name>
        <name type="ordered locus">Dtur_1279</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583639.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353171.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0B2"/>
    <dbReference type="SMR" id="B8E0B2"/>
    <dbReference type="STRING" id="515635.Dtur_1279"/>
    <dbReference type="EnsemblBacteria" id="ACK42557">
        <property type="protein sequence ID" value="ACK42557"/>
        <property type="gene ID" value="Dtur_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1279"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1319"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_1_0"/>
    <dbReference type="InParanoid" id="B8E0B2"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036346">
        <property type="entry name" value="GTP-bd_prot_GTP1/OBG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015349">
        <property type="entry name" value="OCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09269">
        <property type="entry name" value="DUF1967"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102741">
        <property type="entry name" value="SSF102741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51881">
        <property type="entry name" value="OCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000385897" description="GTPase Obg">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Obg" evidence="3">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="1">
        <location>
            <begin position="159"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="OCT" evidence="2">
        <location>
            <begin position="347"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="280"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="309"/>
            <end position="311"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01231"/>
        </source>
    </evidence>
    <sequence length="434" mass="48841" checksum="B2E0CA14904A66E4" modified="2009-03-03" version="1">MFIDRAKIYVKAGDGGNGCIAFRREKFVPKGGPAGGDGGKGGDVIIEADENLDTLLDFHYKRHYYAERGEHGKGKNQKGKDGKDLVIKVPVGTLIFDVETGELLADLVSHGQRVVVAKGGKGGRGNAHFATSTRQTPYFAEKGEKGEERWLYLELKLLADVGLLGLPNAGKSTLLSRISNATPEIAPYPFTTKTPNLGVVEREDITFTVADIPGLIEGAHENKGMGDEFLRHIERTSVLVFVLDAADMVNPPQRAYEILKKELYLYSPKLLEKPRIIAINKIDLPEAQERIPEIEEWLKNEGVPYVFISAKEGINIDKLLELMEKYVKEKKESIPVVEIEKEIEELKQENKKQEIPEIIKEGDLWILKDKKTESLANKLDLYNPQAFSYFLNYAKRRGIIKLINRAKIKDDEEIKIGNYVFKYNSKNNSLELIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0C4</accession>
    <name>B8E0C4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353183.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1292"/>
    <dbReference type="EnsemblBacteria" id="ACK42569">
        <property type="protein sequence ID" value="ACK42569"/>
        <property type="gene ID" value="Dtur_1292"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1292"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_4_2_0"/>
    <dbReference type="InParanoid" id="B8E0C4"/>
    <dbReference type="OMA" id="DIRNYTD"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="110" mass="12628" checksum="9AB4CEA9354A32C3" modified="2009-03-03" version="1">MDEDKEIKIISERLKEVREKRGLTKKELALKIGVSPSTITRYEEEGRVPKLTILKRISEVLDVSIDYLLGKEEVKIATCLSYGDLSDLPEPAIKSIEEFVDFVRKKYGKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0D2</accession>
    <name>PROA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="1">GPR</shortName>
            <ecNumber evidence="1">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proA</name>
        <name type="ordered locus">Dtur_1303</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583659.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353191.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0D2"/>
    <dbReference type="SMR" id="B8E0D2"/>
    <dbReference type="STRING" id="515635.Dtur_1303"/>
    <dbReference type="PRIDE" id="B8E0D2"/>
    <dbReference type="EnsemblBacteria" id="ACK42577">
        <property type="protein sequence ID" value="ACK42577"/>
        <property type="gene ID" value="Dtur_1303"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1303"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1347"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0D2"/>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="OrthoDB" id="223669at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000193600" description="Gamma-glutamyl phosphate reductase">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <sequence length="415" mass="46421" checksum="34DA55A05DF68700" modified="2009-03-03" version="1">MENLIEKLKKAKVSSYTLALLNTNEKNEALRAIANNIEKNIDKIIKENEKDLKRGEEKGLSKAVLDRILLNEKRLRDIIKSIDDVIKLPDPVGEIVSMQKRPNGILVGQMRVPIGVIAIIYEARPNVTVDATILALKSGNAIVLRGSSDALNSNIIITEIMKEALSNTKVPPDTVQIIESPEHSVVEELLQMVDYIDVAIPRGSAKFIKHVMNISKVPVIETGAGNNHIYVEEDADFEMARKIIINAKVQRPSVCNAIEKLLIHKNIAEEFLPIIAKDLREYNVEIRGCKRTLKILTDAIPATEEDWYTEYLDYIIAIKIVESIDEAIEHINKYNTKHSEAIITKDYYKALKFLRMVDAAAVYVNASTRFTDGGEFGLGAEIGISTQKLHARGPMGLKELTTTKYVILGEGQIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0D3</accession>
    <name>B8E0D3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">proC</name>
        <name evidence="5" type="ordered locus">Dtur_1304</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583660.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353192.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1304"/>
    <dbReference type="EnsemblBacteria" id="ACK42578">
        <property type="protein sequence ID" value="ACK42578"/>
        <property type="gene ID" value="Dtur_1304"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1304"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1348"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_0"/>
    <dbReference type="InParanoid" id="B8E0D3"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="OrthoDB" id="1349288at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="3">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="4">
        <location>
            <begin position="159"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="272" mass="30214" checksum="132810990C44ACC6" modified="2009-03-03" version="1">MKLGIIGGGMMGEAILSGIIDSNFLKNDEIIVSEPIEKRREYLRDKYNVEVISDNKLIAKKAKYILIAVKPQNIKDVLKEISPNIDENKTIISIAAGVKISLIKRYLNKFKCIIRIMPNLPCTVKKGAIALTFDKYDKEEVEFVKNLFSTIGSVWIVDEKYFDTITALTGSGPAFVSTILQGFTLSGVKGGLSYDISKEMVLKLFEGVIEYIREKNLSFEEVVKMTSSPAGTTIMGLETLHKEGIVGIIMEAITSAKLRSEEISKYLEEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0D8</accession>
    <name>B8E0D8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="14">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="14">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pheT</name>
        <name evidence="19" type="ordered locus">Dtur_1309</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="14"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583665.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353197.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1309"/>
    <dbReference type="EnsemblBacteria" id="ACK42583">
        <property type="protein sequence ID" value="ACK42583"/>
        <property type="gene ID" value="Dtur_1309"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1309"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1354"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0D8"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 14 19" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="16">
        <location>
            <begin position="39"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="18">
        <location>
            <begin position="401"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="17">
        <location>
            <begin position="705"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ACK42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="799" mass="91890" checksum="66A5EA620F08FC2B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0E9</accession>
    <name>SYGA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyQ</name>
        <name type="ordered locus">Dtur_1320</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583676.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353208.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0E9"/>
    <dbReference type="SMR" id="B8E0E9"/>
    <dbReference type="STRING" id="515635.Dtur_1320"/>
    <dbReference type="EnsemblBacteria" id="ACK42594">
        <property type="protein sequence ID" value="ACK42594"/>
        <property type="gene ID" value="Dtur_1320"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1320"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1365"/>
    <dbReference type="eggNOG" id="COG0752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057066_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0E9"/>
    <dbReference type="OMA" id="SYYQFQV"/>
    <dbReference type="OrthoDB" id="676868at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000197184" description="Glycine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <sequence length="299" mass="34990" checksum="8B23FA26D0FF2E0D" modified="2009-03-03" version="1">MLFQEIIFKLNEFWHNQGCIIQQPYDIEVGAGTMNPATFFRVLGPEPWYVAYVEPSRRPTDGRYGENPNRLQHYYQYQVILKPSPADVQEIYIESLKYLGIEIEKHDIRFVEDNWESPTLGAWGIGWEVWLDGMEITQFTYFQQCGGFDLFPVSAEITYGLERIAMYIQGVDDFKAIKWQDNVTYGDVHLQSEVENCIYNFELADVERLRLLFNEYEKEAERLLNQGLTFPAYDYVLKCSHTFNLLDARGAISVVQRSQYISRIRRLAARAAENYLKSREALGFPLLNKAWRKEEARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0F6</accession>
    <name>B8E0F6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_1327</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583683.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353215.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1327"/>
    <dbReference type="EnsemblBacteria" id="ACK42601">
        <property type="protein sequence ID" value="ACK42601"/>
        <property type="gene ID" value="Dtur_1327"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1327"/>
    <dbReference type="eggNOG" id="COG0818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112343_2_2_0"/>
    <dbReference type="InParanoid" id="B8E0F6"/>
    <dbReference type="OMA" id="SFRYAAQ"/>
    <dbReference type="OrthoDB" id="1893988at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="120" mass="13622" checksum="03544EF7CE65E40B" modified="2009-03-03" version="1">MRNRNLIESITKAVEGLEFGLKYERNIKIQAFIALLVVLFSLILNFDLTDKLLIFMWCGVVISAEFFNSAIERAMDVLSEEYSPKIKIVKDLSASAVFILALIALVSGLLIFFKYLSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0G0</accession>
    <name>B8E0G0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MiaB-like tRNA modifying enzyme</fullName>
            <ecNumber evidence="10">1.3.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1331</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.3.1.74" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583686.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353219.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1331"/>
    <dbReference type="EnsemblBacteria" id="ACK42605">
        <property type="protein sequence ID" value="ACK42605"/>
        <property type="gene ID" value="Dtur_1331"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1331"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1376"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0G0"/>
    <dbReference type="OMA" id="HFHIPLQ"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035600">
        <property type="term" value="P:tRNA methylthiolation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="116"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="417" mass="48610" checksum="9278F4C423DFC0DC" modified="2009-03-03" version="1">MRKVAFYTFGCKVNQYETENLKILARNAGFEIVPFGKEADLIFINSCAVTHVAERKARRLINLIKNRFPNAKIALAGCYAERLNLSSEKLVLDFVLDNKQKWEFFGGSEDSAFVTSEDRARAILKIQDGCNNFCTYCIVPYLRGRERSKPFDKVMEEAQKLVENGFKEIVLTGIRLGAYGRDLGDKDALSKLLLKLFEMDGLVKIRLSSIEPMDITEGLIKLADHPKLCKHWHIPLQSGDDEILKKMNRRYDTKYFEQIVYKLREKVPDVAITTDIIVGYPEESEENFNNTYLFAERMGFMRIHVFPYSPRPFTPAYKLKPLPYEVITKRKEKLIKLSNDLWERYVSKFIEKELEVMVEERKENLYRGTTDNYIKVEFESNLLLKEGEYIKVRLLKVDNKEEKVWGEVLESKVKVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0G2</accession>
    <name>B8E0G2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hrcA</name>
        <name evidence="7" type="ordered locus">Dtur_1333</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583688.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353221.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1333"/>
    <dbReference type="EnsemblBacteria" id="ACK42607">
        <property type="protein sequence ID" value="ACK42607"/>
        <property type="gene ID" value="Dtur_1333"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1333"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1378"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050019_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0G2"/>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="OrthoDB" id="1510750at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="103"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="343" mass="39332" checksum="EF99377C5F02BACA" modified="2009-03-03" version="1">MLDERKKTILKITVKDYIESAHPVSSRVLAKKYLLGWSPATIRNEMADLEEEGYLIQPHTSAGRIPSDRGYRFYVDFLLDGYELYEEDIKVANSIIFSVLDWESLLKKVAELMSERTTFIGVVLYPQLRNTTLKKIEFVDLREETVVIIVTTATGIVKEKIIRLSRSITEEELQRIRVKLNKEFGNKELQKVYWNLSKEEKRINIPSEIIETLKDILKELIYTGKEEGVFVSGLSKILKHLEFQDINKVKTLVDVLEEEKTLSSLLFTAFLNKGLTILIGQEINIPELSDCSVITTVYSLGDNITGSIGMIGPKRMKYERILAFVELIGKTLSERLTQILGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0G9</accession>
    <name>B8E0G9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583695.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353228.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1340"/>
    <dbReference type="EnsemblBacteria" id="ACK42614">
        <property type="protein sequence ID" value="ACK42614"/>
        <property type="gene ID" value="Dtur_1340"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1340"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098588_2_0_0"/>
    <dbReference type="InParanoid" id="B8E0G9"/>
    <dbReference type="OMA" id="IYHCGPL"/>
    <dbReference type="OrthoDB" id="1627779at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="11"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="174" mass="19443" checksum="0C78F7EE6CEC4ECB" modified="2009-03-03" version="1">MKRIYIPDDIEKLERFEVGEWILLNGVLYSARDQACKKLVDMIDKGVELPFNLKDIIIYHMGPSPAPPGRVVGSAGPTTSKRMDPFVAELMRNGVKGFIGKGMRGKEVIEAIKKYKGFYLVTVGGAGAYLGDRIKNMEILAFPELGPEAIYYLEVFDFPAMMAIDSKGNSFWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0P0</accession>
    <name>B8E0P0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FHA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584134.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353674.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1788"/>
    <dbReference type="EnsemblBacteria" id="ACK43060">
        <property type="protein sequence ID" value="ACK43060"/>
        <property type="gene ID" value="Dtur_1788"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1788"/>
    <dbReference type="eggNOG" id="COG1716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131367_1_1_0"/>
    <dbReference type="InParanoid" id="B8E0P0"/>
    <dbReference type="OMA" id="LPINWAY"/>
    <dbReference type="OrthoDB" id="268932at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="81"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="153" mass="17400" checksum="40ACF6436C14E918" modified="2009-03-03" version="1">MSITLYILLILFIILLAIDIILRLRKEKKPQFHKLEKGEEIIGTSNTMKLDASLLPINWAYLIVKHGENRGKDFKIVKDETTIGREQENDIVIPNPTVSRFHAKIIRSEDKYFIEDLGSANGTMVNGIKVTKELLHDGDIVQLGDVVLVFKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Q0</accession>
    <name>B8E0Q0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584144.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353684.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1798"/>
    <dbReference type="EnsemblBacteria" id="ACK43070">
        <property type="protein sequence ID" value="ACK43070"/>
        <property type="gene ID" value="Dtur_1798"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1798"/>
    <dbReference type="eggNOG" id="COG4277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033784_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0Q0"/>
    <dbReference type="OMA" id="GYIHLKA"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023874">
        <property type="entry name" value="DNA_rSAM_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF9">
        <property type="entry name" value="PTHR21180:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01102">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03916">
        <property type="entry name" value="rSAM_link_UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="45"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="377" mass="43999" checksum="84D80D11B3B182DB" modified="2009-03-03" version="1">MNNTEKLEILSEAAKFDLCGSFLCSKESIQRKPTLKGWIYPTTLPDGRTVRLLKILLSNDCIHNCYYCANRRDRNFQRVSFTADELVRLFLELRRKNLVDGLFLSSAVTKSPKYTMEQMLKTVEILREKHNFKGYIHLKILPESSLDYIEAAIRYADRVSVNLEAPKEDYLKEIAPEKNLNLLMSKLEMIKKLSERNLKPKSGITTQFVVGATREKDIEILSLTFKLYQEYNLSRAYFSAFQPIPQTPLEELHPTPTWREVRLYEADFLIRKYNFSIDELIFDENGNLPLREDPKIIWAKANPQFFPIEINTATYEQLLRIPGIGPISAKKIIKVRKEQKIKDIKDLKKLGIQVERCKNYILINGRRPFSEKQLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0S5</accession>
    <name>B8E0S5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="15">ATP-PFK</shortName>
            <shortName evidence="15">Phosphofructokinase</shortName>
            <ecNumber evidence="15">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pfkA</name>
        <name evidence="17" type="ordered locus">Dtur_1388</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 15">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="15"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583740.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353276.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1388"/>
    <dbReference type="EnsemblBacteria" id="ACK42662">
        <property type="protein sequence ID" value="ACK42662"/>
        <property type="gene ID" value="Dtur_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1388"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1435"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_1_0"/>
    <dbReference type="OMA" id="KFAVICV"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00339">
        <property type="entry name" value="Phosphofructokinase_I_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012828">
        <property type="entry name" value="PFKA_ATP_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02482">
        <property type="entry name" value="PFKA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 15 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="16">
        <location>
            <begin position="4"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator; shared with dimeric partner" evidence="15">
        <location>
            <begin position="22"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="170"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP binding; allosteric activator" evidence="15">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="15">
        <location>
            <begin position="250"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="73"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="103"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <note>allosteric activator</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ACK42662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="319" mass="35065" checksum="9BF563591D4F998B" modified="2009-03-03" version="1">MIRRIGVLTSGGDAPGMNSAIRAIVRFGISKGIEIIGIERGYQGLIEGEFKVLSRDDVSEIVQKGGTILRTARSDEFREEEGQKKAIENMEKHGLDALIVIGGEGSLKGAYDLFKKGINVVGIPGSIDNDVWGTDFSIGFDTACNNVIDAINKIRDTAAAHERTFVIEVMGRECGFIAFTSGLVSGADIILIPEVPIDFPYITEKLRERQKRKKRHNIIVVAEGVGSAYFIGKQIEDKLGISTRIVVLGHIQRGGSPSVFDRNMATFMGVEAIKRLLNGEGGVMIGWQKNSPVPISLEEVSKYKKRVPPELYWEVECLW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0T1</accession>
    <name>PIMT_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="1">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcm</name>
        <name type="ordered locus">Dtur_1394</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583746.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353282.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0T1"/>
    <dbReference type="SMR" id="B8E0T1"/>
    <dbReference type="STRING" id="515635.Dtur_1394"/>
    <dbReference type="EnsemblBacteria" id="ACK42668">
        <property type="protein sequence ID" value="ACK42668"/>
        <property type="gene ID" value="Dtur_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1394"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1441"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_0"/>
    <dbReference type="InParanoid" id="B8E0T1"/>
    <dbReference type="OMA" id="TISAIHM"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000192389" description="Protein-L-isoaspartate O-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <sequence length="220" mass="25096" checksum="600D2FBECAFA138C" modified="2009-03-03" version="1">MSFKDFDAPKYKYKRKSLVEILKNEGIKSQKVLDAILKVPRHIFVPSEYLDLAYENEALPIGYEQTISQPYIVALMTEALDLKGDEKVLEIGTGSGYQTAILAELAKEVYTIERIRELSEEAKKRIKLLGYSNVYFKVGDGTLGWEEFSPYDRIIVTAASYDIPNPLKEQLKDGGVMVIPIGGRDFQYLYKITKKNGNFYRENLGGVRFVPLKGEYGWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0V4</accession>
    <name>B8E0V4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase</fullName>
            <shortName evidence="3">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purN</name>
        <name evidence="5" type="ordered locus">Dtur_1417</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583769.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353305.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1417"/>
    <dbReference type="EnsemblBacteria" id="ACK42691">
        <property type="protein sequence ID" value="ACK42691"/>
        <property type="gene ID" value="Dtur_1417"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1417"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1464"/>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0V4"/>
    <dbReference type="OMA" id="TGITIHY"/>
    <dbReference type="OrthoDB" id="1815747at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="3">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="3">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="205" mass="23176" checksum="0296474DAC45D949" modified="2009-03-03" version="1">MERKRLGVLVSGRGSNLQALIDASKDENYPAEVVVVISNNPSAYAIERAKRENIPVFVIRREDYKSKKEYEEKIKEVLQNFKVDLVVLAGYMKIVGKTLLEAFPNRIINIHPSLLPSFPGLEAQRQAWEYGVKISGCTVHFVDEGIDSGPIIGQRAVPVYDDDTPATLAERILQEEHKLIVESVKKILTEDFEIIGRRVVFKKRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0W1</accession>
    <name>ENO_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno</name>
        <name type="ordered locus">Dtur_1424</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583776.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353312.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0W1"/>
    <dbReference type="SMR" id="B8E0W1"/>
    <dbReference type="STRING" id="515635.Dtur_1424"/>
    <dbReference type="EnsemblBacteria" id="ACK42698">
        <property type="protein sequence ID" value="ACK42698"/>
        <property type="gene ID" value="Dtur_1424"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1424"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1471"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_0"/>
    <dbReference type="InParanoid" id="B8E0W1"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_1000119571" description="Enolase">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="363"/>
            <end position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="424" mass="46228" checksum="BD7CEE5A45436DAC" modified="2009-03-03" version="1">MPAILDVHGREVLDSRGNPTVEAEVYLEDGSVGRAIVPSGASTGSREALELRDNDPKRYKGKGVLQAVKNINEIIAQELIGLEALNQYTVDKTMLELDGTENKSRLGANAILAVSLATARAAAASLGVPLYVYLGGVQARELPTPLMNVINGGKHADNPLDFQEYMIVPLASTFKESLRWAVEVFHTLRSILKSKGLNTNVGDEGGFAPYLEKNEDPLAILVEAIQKAGFEPGKDVALALDLAASEFYEDGKYILKAEGKELTSDEMISLLEYLCDKYPIVSIEDGLSEKDWDGWKKLTDKLGKRVQLVGDDIFVTNPQILAEGIEKGIANAILVKVNQIGSLTETLDTIRIAHQAGYRTVISHRSGETEDTFIADLAVAVNSGQIKTGSLSRTDRIAKYNQLLRIEEDLGEAALYRGILNFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0X5</accession>
    <name>B8E0X5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase membrane zinc metallopeptidase putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583790.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353326.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1438"/>
    <dbReference type="EnsemblBacteria" id="ACK42712">
        <property type="protein sequence ID" value="ACK42712"/>
        <property type="gene ID" value="Dtur_1438"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1438"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1485"/>
    <dbReference type="eggNOG" id="COG2738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084406_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0X5"/>
    <dbReference type="OMA" id="VQHATAY"/>
    <dbReference type="OrthoDB" id="1656873at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007395">
        <property type="entry name" value="Zn_peptidase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36434">
        <property type="entry name" value="PTHR36434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04298">
        <property type="entry name" value="Zn_peptidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="229" mass="25144" checksum="1C1742D100B1521B" modified="2009-03-03" version="1">MLFWWDPTYILLLPALILSIYASMKVRSTFAYYSEIPNSRRLTGREAAEIILRSIGLDNVRIEPIPGTLTDHYDPTTKVLRLSEPVYSEPSVAALGVAAHEIGHAIQHATGYYALALRSSLVPVANIGTNLAFPLFFLGFIFGSSSLMNIGILAFSLAVLFYLITLPVEINASKRAQEVLLSLGLVTQREAEGVKKVLNAAALTYLAAALTALLNLLRLILLANMRRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0X8</accession>
    <name>B8E0X8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">priA</name>
        <name evidence="14" type="ordered locus">Dtur_1441</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583793.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353329.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1441"/>
    <dbReference type="EnsemblBacteria" id="ACK42715">
        <property type="protein sequence ID" value="ACK42715"/>
        <property type="gene ID" value="Dtur_1441"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1441"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1488"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_392195_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0X8"/>
    <dbReference type="OMA" id="MISKGHD"/>
    <dbReference type="OrthoDB" id="1132322at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PriA_3primeBD" evidence="11">
        <location>
            <begin position="16"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PriA_CRR" evidence="13">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="PriA_C" evidence="12">
        <location>
            <begin position="606"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="449"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="703" mass="82323" checksum="1566515E0D2E239E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1C2</accession>
    <name>DTD_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name type="ordered locus">Dtur_0970</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583334.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352864.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1C2"/>
    <dbReference type="SMR" id="B8E1C2"/>
    <dbReference type="STRING" id="515635.Dtur_0970"/>
    <dbReference type="EnsemblBacteria" id="ACK42250">
        <property type="protein sequence ID" value="ACK42250"/>
        <property type="gene ID" value="Dtur_0970"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0970"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1007"/>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1C2"/>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="OrthoDB" id="1862614at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006399">
        <property type="term" value="P:tRNA metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000127522" description="D-aminoacyl-tRNA deacylase">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <sequence length="156" mass="17842" checksum="DCC5D5CE98166D1C" modified="2009-03-03" version="1">MRAVIQRVKKASVKVNGELISQISQGLLIFLGISKKDKEEDIKILADKIADLRIFSDENGKMNLSIKEVNGDILVVSQFTLFADCRRGKRPDFTDAADKEKALDYYKKFVAYLKNKSEKVEEGIFQAYMEVELINDGPVTIILDTEDLKKPRRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1E0</accession>
    <name>B8E1E0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="10" type="ordered locus">Dtur_0988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583352.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352882.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0988"/>
    <dbReference type="EnsemblBacteria" id="ACK42268">
        <property type="protein sequence ID" value="ACK42268"/>
        <property type="gene ID" value="Dtur_0988"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0988"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1025"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1E0"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="139" mass="15350" checksum="41A61BCE126943B8" modified="2009-03-03" version="1">MLMPKRVKYRKQHRGRMKGKASRGNRVVFGDYGIQALAPAWITSEQIEAVRRTLTRHAGKNGRVWIRIFPDKSVTARPAESRMGGGKGDVKGWVAVVKPGTILFEIGGVSKEIAMEAIRIAGSKLPIKTRLVTREIGGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1E3</accession>
    <name>RL14_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplN</name>
        <name type="ordered locus">Dtur_0991</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583355.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352885.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1E3"/>
    <dbReference type="SMR" id="B8E1E3"/>
    <dbReference type="STRING" id="515635.Dtur_0991"/>
    <dbReference type="EnsemblBacteria" id="ACK42271">
        <property type="protein sequence ID" value="ACK42271"/>
        <property type="gene ID" value="Dtur_0991"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0991"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1028"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1E3"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000144261" description="50S ribosomal protein L14">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <sequence length="120" mass="13299" checksum="271D936145D09473" modified="2009-03-03" version="1">MIMPQTRLVVADNTGAKEIMCFRILGKKKVAQVGDIIVASVKEAVPRSNIKKGDVVYAVVIRTKRTIKRKDGSCVRFDDNAAVIIDKEGNPRGTRVFGPVARELRDKNFMKIISLATEVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1E4</accession>
    <name>RL24_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplX</name>
        <name type="ordered locus">Dtur_0992</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583356.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352886.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1E4"/>
    <dbReference type="SMR" id="B8E1E4"/>
    <dbReference type="STRING" id="515635.Dtur_0992"/>
    <dbReference type="EnsemblBacteria" id="ACK42272">
        <property type="protein sequence ID" value="ACK42272"/>
        <property type="gene ID" value="Dtur_0992"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0992"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1029"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1E4"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000165942" description="50S ribosomal protein L24">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <sequence length="105" mass="11831" checksum="DF5A5C1C001C40B8" modified="2009-03-03" version="1">MDIKKGDLVLVISGKDKGKRGRVISVLPSEEKVVVEGVNIVKKHTRPTAKMRQGGIIEKPAPLYRCKVMLICPHCNQPTRVKHTFLEDGRKVRVCSKCKEIIDRV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1F8</accession>
    <name>RS11_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsK</name>
        <name type="ordered locus">Dtur_1006</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583369.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352900.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1F8"/>
    <dbReference type="SMR" id="B8E1F8"/>
    <dbReference type="STRING" id="515635.Dtur_1006"/>
    <dbReference type="EnsemblBacteria" id="ACK42286">
        <property type="protein sequence ID" value="ACK42286"/>
        <property type="gene ID" value="Dtur_1006"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1006"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1043"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_0"/>
    <dbReference type="InParanoid" id="B8E1F8"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000141086" description="30S ribosomal protein S11">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <sequence length="131" mass="13982" checksum="6A344CDCAD87F242" modified="2009-03-03" version="1">MAKKKRTRGPKKEKRIVPVGVAHINSTFNNTIVTITDPEGNVLTWGSGGTAGFKGTKKGTPFAAQLAAEMAAKKAISEYGMKKVDVLVKGPGPGRETAIRALQAAGLEISLIKDVTPIPHNGCRPPRRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1G7</accession>
    <name>B8E1G7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="9" type="ordered locus">Dtur_1015</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583378.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352909.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1015"/>
    <dbReference type="EnsemblBacteria" id="ACK42295">
        <property type="protein sequence ID" value="ACK42295"/>
        <property type="gene ID" value="Dtur_1015"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1015"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1052"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1G7"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="OrthoDB" id="1766414at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="138" mass="15636" checksum="53521512EA335BF5" modified="2009-03-03" version="1">MLEFTSQDVKVIHEVGGRKTSRVKVWLRFPGEGKIIVNDKPLEEYFGGRIFFHKIAKKPLELTGMLNQVDVIAQAIGGGVSAQAQALAHGISKALVALKEDWKTLLKKEGLLKRDPREKERKKYGLKRARRAPQYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1I7</accession>
    <name>B8E1I7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transketolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582597.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352126.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0183"/>
    <dbReference type="EnsemblBacteria" id="ACK41512">
        <property type="protein sequence ID" value="ACK41512"/>
        <property type="gene ID" value="Dtur_0183"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0183"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.189"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_3_1_0"/>
    <dbReference type="InParanoid" id="B8E1I7"/>
    <dbReference type="OMA" id="NSGHSGM"/>
    <dbReference type="OrthoDB" id="188169at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016744">
        <property type="term" value="F:transketolase or transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="7">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="640" mass="71367" checksum="24482D2D50208105" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1J2</accession>
    <name>B8E1J2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582602.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352131.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0188"/>
    <dbReference type="EnsemblBacteria" id="ACK41517">
        <property type="protein sequence ID" value="ACK41517"/>
        <property type="gene ID" value="Dtur_0188"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0188"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_2_0"/>
    <dbReference type="InParanoid" id="B8E1J2"/>
    <dbReference type="OMA" id="LILEMAV"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="39"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="150" mass="17731" checksum="B625B74C73D56D61" modified="2009-03-03" version="1">MLRRYWDPFEEIRHLQREMDRLFADFFGETTAIEERRGAYAPAIDMYETDENIVVKAELPGFKPEDVDISVTEDSVIIQGETKEEEEVKRENFYRKERRIGRIYRRIDLPKPVVPDKSEAVYKNGILTLTLPKAKPEKLEGIKIKIKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1M8</accession>
    <name>B8E1M8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SIS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582638.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352167.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0224"/>
    <dbReference type="EnsemblBacteria" id="ACK41553">
        <property type="protein sequence ID" value="ACK41553"/>
        <property type="gene ID" value="Dtur_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0224"/>
    <dbReference type="eggNOG" id="COG4821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089975_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1M8"/>
    <dbReference type="OMA" id="VDVMPAT"/>
    <dbReference type="OrthoDB" id="1605411at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="240" mass="27414" checksum="723977BA66639DBF" modified="2009-03-03" version="1">MRYLKSMIVLLEELEKEEESFHKVIDKTVDVIRNGGIIHILGYGHYNAIPMELFFKPGVLSCINPILDISTLYPENIYKANYLEKIEDYGKNLISNENIKESDILYIISYTGRDFIAIDACLEAKKKGIFTIGFINRENSIKPSKHSSKKNLKDLVDLAVLLPGPSDELLLSLKENKDVRVGNLGVLLPLLVINDILVEVIYKIEEIGIIPPVFRLPINEKNKEINKKLIDIYKEKIRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1P6</accession>
    <name>B8E1P6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582656.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352185.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0245"/>
    <dbReference type="EnsemblBacteria" id="ACK41571">
        <property type="protein sequence ID" value="ACK41571"/>
        <property type="gene ID" value="Dtur_0245"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0245"/>
    <dbReference type="HOGENOM" id="CLU_1193277_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="232" mass="26762" checksum="830D4CE989233B33" modified="2009-03-03" version="1">MKTRYFKIILIFLSMLLVLGFALAQSDSEELVQIETEEFVEELEEVEVLNLIQNGDFESGQLSPWEVVLINIKDFNKYEAEIFVDYFMWARKNSEADGGYIGIKQSLGNYDVKEKKTLKLSFDILVSLQELDSDGWAGGEYPANVELVFVDENNEEYVYKKCFILRGSKINYPENNVTEIDSGDFYHFEIDLMQDHEILENILSHPYLKEIRVGGSGWDFVGAVDNIFLTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Q4</accession>
    <name>B8E1Q4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582664.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352193.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0253"/>
    <dbReference type="EnsemblBacteria" id="ACK41579">
        <property type="protein sequence ID" value="ACK41579"/>
        <property type="gene ID" value="Dtur_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0253"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_0"/>
    <dbReference type="InParanoid" id="B8E1Q4"/>
    <dbReference type="OMA" id="WGYETYL"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="261"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="283"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="453" mass="52658" checksum="02A54FD4D0B57422" modified="2009-03-03" version="1">MKDFFENISSCFLIVNSQGLVLECDSNFEKKSGYKREEVKDKKHIYEILGDISSWKKLDWGYETYLTKSNGEKIKIFINFFSFSDYNLNIITINDFSFLTYMYENYASFISQSPFPIIEVDLSEMFNYFRIIKKIAGNEIDKYLEIYPEAIYEIIGKIKFIYINESFYNEYKGFSFDALKENVFNYFTEEGLNTLKNELLKVYDGNLNLNFEVEVIDPIGKLRFINVYVYPVGRERVLIYILDKTKERELEEDLRRSVSKITNLYNQVINTLSSIMEHKDSYTAYHQKRVAELSHAIAKEIGLPKDKVDAIRIGALLHDIGKIAIPGEILNKPGKLNNIEMEIVKTHPLTGYNMLKNIDFPPEVLYIVLQHHERLDGSGYPEGLKNGEINLSARIVAVADVVEAMISHRPYRPPFGIDKALEEIEKNKGTKYDPDVVDACIRLFKEKDFKFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1R1</accession>
    <name>B8E1R1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate/ketoisovalerate oxidoreductase, gamma subunit</fullName>
            <ecNumber evidence="3">1.2.7.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.2.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582671.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352200.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0260"/>
    <dbReference type="EnsemblBacteria" id="ACK41586">
        <property type="protein sequence ID" value="ACK41586"/>
        <property type="gene ID" value="Dtur_0260"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0260"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.273"/>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1R1"/>
    <dbReference type="OMA" id="PDYVIVQ"/>
    <dbReference type="OrthoDB" id="1777574at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011894">
        <property type="entry name" value="PorC_KorC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02175">
        <property type="entry name" value="PorC_KorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="13"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="190" mass="21189" checksum="47BD44E3251EF1F2" modified="2009-03-03" version="1">MKDMLEIRWHARAGQGAKTASYLLAETAMEAGKYIQAFPEYGPERTGAPMKAYTRISDKPIRIHSQIYNPDVVVVLDKTLIGKVNILEGLPSDGILIVNTTQSPKEIREQLGISDRKIYTVDATGIALETIGRPIPNTPMLGALIRVVPIISLDEVLNQFRKKFEGRFRPEVVEGNLQAIKRAYEEVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1U3</accession>
    <name>B8E1U3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582811.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352340.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0423"/>
    <dbReference type="EnsemblBacteria" id="ACK41726">
        <property type="protein sequence ID" value="ACK41726"/>
        <property type="gene ID" value="Dtur_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0423"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965407_0_0_0"/>
    <dbReference type="OMA" id="ATHRFHG"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="38562" checksum="ADFAED318A58279F" modified="2009-03-03" version="1">MKVHIDIGINGAFLTRRWEDPENFIKLTKELGYDYHSFCSDVLDPFFSGDKIYQIETAKKIREYAEKYNVKIWDYYTGMATHRFHGLSHSDERVRQRMKEWIISAMDIVKEMGAKYLGGHWDALSVEVLQDPEKTRERIKYVYETFKELAKIAKEKGLLGISNEQMYIPSEKPWTLQEAEEFLIEVNKKNDGVPIYITIDVGHQAGMHYGLSGEDLSYEEWLKRFAVFSPIIHLQQTTRDASAHWPFTEEYNAIGHVKIEKVLSAIEYSFKHYKESPISQYLKPVEEIILIAEIIPSSTKTEEKLLKELKETAEYLRNYIPKGGIYYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1U4</accession>
    <name>B8E1U4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582812.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352341.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0424"/>
    <dbReference type="EnsemblBacteria" id="ACK41727">
        <property type="protein sequence ID" value="ACK41727"/>
        <property type="gene ID" value="Dtur_0424"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0424"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.448"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006033_3_1_0"/>
    <dbReference type="InParanoid" id="B8E1U4"/>
    <dbReference type="OMA" id="ICRYGRS"/>
    <dbReference type="OrthoDB" id="599627at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="10"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="222" mass="24655" checksum="0BE92F21DDFC7A07" modified="2009-03-03" version="1">MNSEIEKVKRELVKIGKRIAQENLIVGPGGNISAKVGNRVYIKASGISFEDATEDDYIGVDFNSGEVIEGDKKPSSEIWMHLECYKVREDVKAVVHTHPIYSIAYAFQDEPLKLFTPDMVALLGGEIPVVEYVVPGGKEFAGVVGGVIKNHNGVLVKNHGLVTVGSNLKEALYRTLLIENSIKTIFVAKLFGKMGFFTKEQIEEIDSLEVEKYRRKLLKEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1V7</accession>
    <name>B8E1V7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582825.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352354.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0438"/>
    <dbReference type="EnsemblBacteria" id="ACK41740">
        <property type="protein sequence ID" value="ACK41740"/>
        <property type="gene ID" value="Dtur_0438"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0438"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.463"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="InParanoid" id="B8E1V7"/>
    <dbReference type="OMA" id="FYAPSLI"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="302" mass="35067" checksum="20557F2144CC6ECE" modified="2009-03-03" version="1">MKKLTKKRKHDIFMGYLFTSPWILGFLFFIVFPLITSFYLSFTRYDILSAPRWIGLQNWIRMFTQDPRFWNATKATFKYVIFEVPLRLLFAFIVALIFSQRESKILNLYRAIYYIPSLIGGSVAIAVVWRQIWGYPDGIVNAILSILGLKGMNWLGDTRTAIWTLILLAVWQFGSPMLIFLAALKQVPTELYEAATIDGANFWGRLFKITIPMVTPVILFNLINQMIHAFMAFTQSYIITQGGPLDSTLFYAVYMYRKAFNDFEMGYASALAWFMLTLVGIFTIIIFKTSNRWVYYEAEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1W7</accession>
    <name>B8E1W7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine aldolase</fullName>
            <ecNumber evidence="7">4.1.2.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.5" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582835.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352364.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0449"/>
    <dbReference type="EnsemblBacteria" id="ACK41750">
        <property type="protein sequence ID" value="ACK41750"/>
        <property type="gene ID" value="Dtur_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0449"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.474"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_0_4_0"/>
    <dbReference type="InParanoid" id="B8E1W7"/>
    <dbReference type="OMA" id="NKGGGAC"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="343" mass="38559" checksum="16407AC223EBCA8F" modified="2009-03-03" version="1">MRFIDLRSDTVTKPTEEMRKAMYEAEVGDDGYGEDPTVNLLEQKAAELLGKEAGLFVVSGTMGNQVALLTWTRPGDEVILESESHIYYYEAGGMAGNSGVQPFLIDGEEGVMPIEEIEKAIRPKGRVFPKTSLIVLENTHNRAGGKVLPLEYMKEVYEISRKHDIPIHLDGARIFNAAIYLGIPAKEIAKYADSVMFCLSKGLSCPMGSVLVGSKEFIEEARRKRQRLGGGLRQAGVVAACGIVALERMIDRLVEDHEKAQNLYNFLKDIEIFSVKKPDTNILKVRIKINKKAREFLEEFKKYGLLATSFDDETLRFVTHKDVSFEDIEKAKEIIYKVWESIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1X0</accession>
    <name>B8E1X0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0145 protein Dtur_0452</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0145 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582838.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352367.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0452"/>
    <dbReference type="EnsemblBacteria" id="ACK41753">
        <property type="protein sequence ID" value="ACK41753"/>
        <property type="gene ID" value="Dtur_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0452"/>
    <dbReference type="eggNOG" id="COG0393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117144_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1X0"/>
    <dbReference type="OMA" id="ETRNQAM"/>
    <dbReference type="OrthoDB" id="2015368at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00338">
        <property type="entry name" value="UPF0145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002765">
        <property type="entry name" value="UPF0145"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035439">
        <property type="entry name" value="UPF0145_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34068">
        <property type="entry name" value="PTHR34068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01906">
        <property type="entry name" value="YbjQ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117782">
        <property type="entry name" value="SSF117782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="107" mass="11644" checksum="1AE776EBA31621E5" modified="2009-03-03" version="1">MIITTTDYIPGYEVSEILGIARGSTARARNVGKDILASFRNLVGGEVVEYTKLIGEAREQALDRMIEEAKRLGADAVIGVRFGTTQIMQGVAEILAYGTAVKLRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E203</accession>
    <name>B8E203_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582871.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352400.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0488"/>
    <dbReference type="EnsemblBacteria" id="ACK41786">
        <property type="protein sequence ID" value="ACK41786"/>
        <property type="gene ID" value="Dtur_0488"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0488"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.513"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_0"/>
    <dbReference type="InParanoid" id="B8E203"/>
    <dbReference type="OMA" id="VSFGMIV"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="78"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="302" mass="34468" checksum="653EA13496F2A6DB" modified="2009-03-03" version="1">MFSRESKIGGAKPRHLINNIIFLGPTITFLTLMLIYPLIYSFYMSLHKWELTQTNPPSFVGFGNYLNLFKDPLFWHALKIQIIFVCTAIPLELIIGLLIALLFQVEFKGNSIMRTLLLLPFFILPSLSGTTWRFILHPTYGVFGAIYRFLGKKPVDWLSNGTLTFIAVILQDIWRTWPFMFITLYAALSNFPQELKEAAAIDGANKFQIFFRIILPLLVPAIIVAVFLRLIDALRIFSEVYVMTEGGPGNATTFLSIFIYKNAFRFFDMGYANAAGYVLTTIAMIVSAIGLTRIFSREVYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E217</accession>
    <name>B8E217_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582885.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352414.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0507"/>
    <dbReference type="EnsemblBacteria" id="ACK41800">
        <property type="protein sequence ID" value="ACK41800"/>
        <property type="gene ID" value="Dtur_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0507"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.538"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="InParanoid" id="B8E217"/>
    <dbReference type="OMA" id="WITDPFW"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="299" mass="33932" checksum="6C5AF77FE7C1C551" modified="2009-03-03" version="1">MKITYKRYLDLWGWLFVIFALFLLTLFLLYPIFYSLYLSTFTTRGIVQTFVGFGNYLRLIKDSNFILALKNTLIILIIQVPIMLFLALILAVILNNQKIKFNGFFRTAIFLPAVTSLVAYTVLFKMMFTTDGLINRFLISLGLISKPIPWLLDPFWAKVTLIFALTWRWTGYNMIFYLAGLQNIPTEIYEAAEIDGANKSVQFFKITIPLLKPIIIFTSIMSTIGTLQLFDEPMNLAAGVVTGSSVGPGNSLLTPSVYIYNICFKYAPNFGYASAVSYILVLIVAILSFIQLRTVGERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E229</accession>
    <name>B8E229_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prepilin leader peptidase/N-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.4.23.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Dtur_1026</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.</text>
            <dbReference type="EC" id="3.4.23.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.4.23.43" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583389.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352920.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1026"/>
    <dbReference type="MEROPS" id="A24.019"/>
    <dbReference type="EnsemblBacteria" id="ACK42306">
        <property type="protein sequence ID" value="ACK42306"/>
        <property type="gene ID" value="Dtur_1026"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1026"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1063"/>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057101_0_1_0"/>
    <dbReference type="InParanoid" id="B8E229"/>
    <dbReference type="OMA" id="VFWLFKL"/>
    <dbReference type="OrthoDB" id="2046608at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="13">
        <location>
            <begin position="12"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="12">
        <location>
            <begin position="105"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="254" mass="28209" checksum="89860818AAECCE13" modified="2009-03-03" version="1">MIKILLTFWFFLLGSAVGSFLNVVIYRLPRRESIVFPPSHCPFCGHKLSAKDLIPILSYIILKGKCRYCGAKISSRYPIVEFLTAIFYALVFWLYGFSFSTLKLLILFSMLLPVFFIDLEHMLIPDVITIPGTGVGLIISLFEGRLAQGILGSLIFGGILLLIYVIALLILKEEGMGQGDIKLGFMLGSFLGIKLSLLSLFLSYFIGGLFSLLIILIKGKDLKTAIPFGPFLIIGALISLFFGKTLINLYLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E262</accession>
    <name>B8E262_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="9" type="ordered locus">Dtur_1059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583422.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352953.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1059"/>
    <dbReference type="EnsemblBacteria" id="ACK42339">
        <property type="protein sequence ID" value="ACK42339"/>
        <property type="gene ID" value="Dtur_1059"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1059"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1096"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_1_0"/>
    <dbReference type="InParanoid" id="B8E262"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="7"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="433" mass="46511" checksum="757DFAEFD90840F9" modified="2009-03-03" version="1">MGKLMIKKSRSLMGEIKIPGDKSISHRALIFSSMGEGESIIKNFLFSQDCISTMNCLRALGTSIEICENVIKVKGNGINGFREPENVLDAGNSGTTIRLFTGLLSGLPGIFSVITGDDSLRRRPMKRVVEPLLGMGAKIWGRNGGNNPPLAIKGEKLKGRDHTLSVASAQVKSALLIAGLLADGETSVTEPSLSRDHTERIFQYLGLPLIRNGLTLKTHGIEGFKNKDFNIPGDFSSAAFIIAAGLLVEGSKIVIKNVGINPTRIGMLSVLKEAGAKIQILNQWEEGGEPIGDLIVEFSILESFEVRGEIVPKLIDEVPILAIIATQAKGKSVFKDVGELKVKESDRIKAVVDGINKMGGKAEIIDEGFAVYGPTKLNGNEIETYNDHRIAMSFAIAGLLADGETIVESNSISISFPNFGETIKKLGGNIIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E282</accession>
    <name>B8E282_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583442.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352973.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1080"/>
    <dbReference type="EnsemblBacteria" id="ACK42359">
        <property type="protein sequence ID" value="ACK42359"/>
        <property type="gene ID" value="Dtur_1080"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1080"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1116"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_5_0"/>
    <dbReference type="InParanoid" id="B8E282"/>
    <dbReference type="OMA" id="YPHMPTG"/>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019881">
        <property type="entry name" value="DAP-NH2Trfase_DapL_Desulfo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03540">
        <property type="entry name" value="DapC_direct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="32"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="401" mass="45177" checksum="FCDFD099073D00D0" modified="2009-03-03" version="1">MIKKAKRIENLPPYLFARIDQLKEEAINRGIDVISLGIGDPDQPTPMPIVQKLCEEALNPANHRYPSYEGLLEYRQAVANWYKYRFNVDLDPKKEVLSLIGSKEGLVHMIWGLVDRGDIVLCPDPGYPVYRISTLLAEGEPYSIPLKIENKFLPKWEDIPTEIAKKAKVMFLNYPSNPTGAVIDKKGLEEAVKFAKEYDIIILYDNAYSEITFDGFVAPSILEIDGAKDIAIEFNSLSKTFNMTGWRIGYAVGNADLISVLSTVKTNVDSGVFQAIQYAAIEALNNLRDFSKESVKIYQRRRDMVLDAFKGMGVEILPPKGTFYVWVSVPEGFTSTDFAAFLLEEIGVLVVPGIGYGDYGEGYIRISTTISEDRLIEALKRVKEFFGRDDWKSKKPSLLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E297</accession>
    <name>B8E297_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion-translocating oxidoreductase complex subunit A</fullName>
            <ecNumber evidence="8">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Rnf electron transport complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rnfA</name>
        <name evidence="9" type="ordered locus">Dtur_1095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NqrDE/RnfAE family.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583457.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352988.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1095"/>
    <dbReference type="EnsemblBacteria" id="ACK42374">
        <property type="protein sequence ID" value="ACK42374"/>
        <property type="gene ID" value="Dtur_1095"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1095"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1131"/>
    <dbReference type="eggNOG" id="COG4657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095255_1_0_0"/>
    <dbReference type="InParanoid" id="B8E297"/>
    <dbReference type="OMA" id="CPFFGVS"/>
    <dbReference type="OrthoDB" id="1814639at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00459">
        <property type="entry name" value="RsxA_RnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011293">
        <property type="entry name" value="Ion_transpt_RnfA/RsxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003667">
        <property type="entry name" value="NqrDE/RnfAE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02508">
        <property type="entry name" value="Rnf-Nqr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006102">
        <property type="entry name" value="NQR_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01943">
        <property type="entry name" value="rnfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="195" mass="21612" checksum="8DD4A0ADC3D116F7" modified="2009-03-03" version="1">MNIIGKLFMLFISASLINNIVFMRFLALCPFVGMSTQIETSIGMGAAVTFVMVMASVVTFFIYYYILVPLNLLFLRTISFILVIAVLVQLVEMVIKKFLSSLYKAMGIYLPLITTNCAILGVTLLNINYGHNLIEAIVYSLGVSLGFTIALILLASIRDRLSYSEIPEFWKGYPIVFISAGLLALIFLGFQGLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2D2</accession>
    <name>B8E2D2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583492.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353023.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1130"/>
    <dbReference type="EnsemblBacteria" id="ACK42409">
        <property type="protein sequence ID" value="ACK42409"/>
        <property type="gene ID" value="Dtur_1130"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1130"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1167"/>
    <dbReference type="eggNOG" id="COG0391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044041_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2D2"/>
    <dbReference type="OMA" id="LCGDDDW"/>
    <dbReference type="OrthoDB" id="665169at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="325" mass="35852" checksum="4ED62590D0C7AAA0" modified="2009-03-03" version="1">MEGRRILTVIGGGTGLSTILRGLKRYNLDLNAIVTVSDDGGSSGRLSKDLGVLPPGDVRNCLVALADEESLMAKLFQYRFTNGDLKDHSFGNLFLVAMSAILGDFLLGVKETSKVLAIRGRVLPSTLKRVKLKAYFEDGSIILGETSISSYGKSKIRKIELVPIDTDVNISATSEAVEALEKSDLIIIGPGSLYTSIIPNLLLEEIKDTLKNIDNKRILYICNVMTQPGETLGYKASDHLRAIVEHMGFNPIGYVLVNTKRPSEEVLKRYREKGADFVEPDLENLRSLGVDILAGDFINEGDLVRHDPFKVADFIMERFINSKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2H2</accession>
    <name>B8E2H2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583891.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353430.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1542"/>
    <dbReference type="EnsemblBacteria" id="ACK42816">
        <property type="protein sequence ID" value="ACK42816"/>
        <property type="gene ID" value="Dtur_1542"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1542"/>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107893_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2H2"/>
    <dbReference type="OMA" id="RACRIYS"/>
    <dbReference type="OrthoDB" id="1100576at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009501">
        <property type="entry name" value="UCP020269"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020269">
        <property type="entry name" value="DUF1121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="13"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="213" mass="24111" checksum="8E13DF1DB0540E9C" modified="2009-03-03" version="1">MKDLESWLTKKQLERTAELLKERGYEVFLVEDREEAKNKVLSLIPREATVGIGGSITIREIGVIEELEKRGNKVIHHWKEGLTPEQDLEIRRQELLSDVFLSSVNALTFSGEIVNMEAIGNRVAAQIFGPKKVIVVVGRNKLVVNLETAIWRIKNIVTPLNAKRLKLELPCADEGYCMNCNHPNRICRITTILEAPPSRTPFTVILVNEDLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2J4</accession>
    <name>B8E2J4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583913.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353452.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1564"/>
    <dbReference type="EnsemblBacteria" id="ACK42838">
        <property type="protein sequence ID" value="ACK42838"/>
        <property type="gene ID" value="Dtur_1564"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1564"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_316364_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2J4"/>
    <dbReference type="OMA" id="WAESSYK"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="1">
        <location>
            <begin position="280"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="922" mass="108490" checksum="D471526234EBF3E3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2J9</accession>
    <name>B8E2J9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_1569</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583918.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353457.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1569"/>
    <dbReference type="EnsemblBacteria" id="ACK42843">
        <property type="protein sequence ID" value="ACK42843"/>
        <property type="gene ID" value="Dtur_1569"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1569"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1618"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_3_0_0"/>
    <dbReference type="InParanoid" id="B8E2J9"/>
    <dbReference type="OMA" id="MEMPDYE"/>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041069">
        <property type="entry name" value="FeoB_Cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0410">Iron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="634"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="659" mass="75238" checksum="E979B56B44EE8F1E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2M6</accession>
    <name>B8E2M6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583945.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353484.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1597"/>
    <dbReference type="EnsemblBacteria" id="ACK42870">
        <property type="protein sequence ID" value="ACK42870"/>
        <property type="gene ID" value="Dtur_1597"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1597"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_8_4_0"/>
    <dbReference type="InParanoid" id="B8E2M6"/>
    <dbReference type="OMA" id="NRYHENP"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
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    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="206" mass="24462" checksum="DAB57E0A6FD38197" modified="2009-03-03" version="1">MGEIYLIRHGETDWNREAKFQGRTDIPLNSKGKSQAELLSDYLAKEKFDYIYSSPLKRAIETAIPLSKKLNKEILIRENWIEFDFGEWEGLTVREVHEKYPIERELWLYHTEKGKIPKGESFEDAYKRLSIEKEYILENHKNHKIVIFTHGAIIRAALYVFLDLYHIGFGKITISSCSITHFKIKDDKFILLRLNYLYPHELFSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2N4</accession>
    <name>B8E2N4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Preprotein translocase, YajC subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583953.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353492.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1605"/>
    <dbReference type="EnsemblBacteria" id="ACK42878">
        <property type="protein sequence ID" value="ACK42878"/>
        <property type="gene ID" value="Dtur_1605"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1605"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116157_5_1_0"/>
    <dbReference type="InParanoid" id="B8E2N4"/>
    <dbReference type="OMA" id="AKKHKEM"/>
    <dbReference type="OrthoDB" id="2082059at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="92" mass="10375" checksum="A0CFEA63D4306E59" modified="2009-03-03" version="1">MEQAVNLISILLVWGAFLAIFYFILVIPQKREAKRRQEMLDSLKVGDRIVTKGGLIGQIVAINKQKKIIQVSFAKGIVFEMLLEGVAYPLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2P5</accession>
    <name>B8E2P5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583964.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353503.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1616"/>
    <dbReference type="EnsemblBacteria" id="ACK42889">
        <property type="protein sequence ID" value="ACK42889"/>
        <property type="gene ID" value="Dtur_1616"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1616"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096412_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2P5"/>
    <dbReference type="OrthoDB" id="2029507at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="237" mass="26829" checksum="D2A3374041660727" modified="2009-03-03" version="1">MNIRLILTDIEGCITKNKGYPLDLLSLQWIRENLKKLPPISLNTGRSKPYIEAILQALGDFQDSIGENGCTIYLVEKDDIVLHPIINDDILKEKEELKKFLKEKIKNLGHIEPGKEVCVSLFPEEGILVKDLAEYTQELIKEEFPEFQLVYSSVAVDITPKGIDKGSGMDILLEMKNLSYDEVLGIGDSLGDFPFLSKLKYKATPANGHPKIKEIATYVAKEEDIKGLIEIFKHFFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2S4</accession>
    <name>RS15_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsO</name>
        <name type="ordered locus">Dtur_1145</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583506.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353038.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2S4"/>
    <dbReference type="SMR" id="B8E2S4"/>
    <dbReference type="STRING" id="515635.Dtur_1145"/>
    <dbReference type="EnsemblBacteria" id="ACK42424">
        <property type="protein sequence ID" value="ACK42424"/>
        <property type="gene ID" value="Dtur_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1145"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1182"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2S4"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000143107" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <sequence length="89" mass="10774" checksum="8931D28DC2D01275" modified="2009-03-03" version="1">MALTKEEKRQIIEKFRLNENDSGSPEVQIALLTERIKKLTEHLKVHKKDYHSRVGLLKMIGRRRKLLKYLQEKDFERYKKLIQELGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2W1</accession>
    <name>B8E2W1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583543.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353075.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1182"/>
    <dbReference type="EnsemblBacteria" id="ACK42461">
        <property type="protein sequence ID" value="ACK42461"/>
        <property type="gene ID" value="Dtur_1182"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1182"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1219"/>
    <dbReference type="eggNOG" id="COG3156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_489886_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2W1"/>
    <dbReference type="OMA" id="TINYIYT"/>
    <dbReference type="OrthoDB" id="276692at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032601">
        <property type="entry name" value="DUF4900"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16241">
        <property type="entry name" value="DUF4900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="568" mass="63284" checksum="1EF21E508C9D5F76" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2W9</accession>
    <name>LEU1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="1">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuA</name>
        <name type="ordered locus">Dtur_1190</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583551.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353083.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2W9"/>
    <dbReference type="SMR" id="B8E2W9"/>
    <dbReference type="STRING" id="515635.Dtur_1190"/>
    <dbReference type="EnsemblBacteria" id="ACK42469">
        <property type="protein sequence ID" value="ACK42469"/>
        <property type="gene ID" value="Dtur_1190"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1190"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1227"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2W9"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000149181" description="2-isopropylmalate synthase">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01151"/>
        </source>
    </evidence>
    <sequence length="503" mass="55320" checksum="284C003DAF3BB327" modified="2009-03-03" version="1">MGKLYIFDTTLRDGEQTPGVNLNKEEKLEIAKQLAKLNVDIIEAGFPIASPGEFEAVKNIAEKVKGPIIAALARAIPMDIDRAWEAIKYSESPRIHTFIATSDIHIEKKLKKTRDEVLEQAVSAVKYAKRYCSDVEFSAEDAVRSDFNFLVKIFEAVIEAGATVINVPDTVGYALPWEFGELIRRLKENIRNIDKARVSVHCHNDLGLATANSLSAIVNGAEQVECTVNGLGERAGNAAMEEIVMAIKVRRLPFEVSIKTEEIYKTSKLVSNLTGIPIQPNKAIVGENAFAHESGIHQHGVIQDPSTYEIIDPKTIGIPESKIVLGKHSGKHAFEKRLQELGYSLPPDQLEEAFRRFKELADKKKEITDKDIEALVSNQIRIIPEYYKLRHLQVVSGIGIVPTATIIISENGEEIKTVEIGNGPVDAVYKAITKAVKVPHSLEDFSLKSVTGGTDALGEAMVKLSDKDGNIYVGRATSTDVIEASALAYLRALNQLVMLKGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2X7</accession>
    <name>B8E2X7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583559.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353091.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1198"/>
    <dbReference type="EnsemblBacteria" id="ACK42477">
        <property type="protein sequence ID" value="ACK42477"/>
        <property type="gene ID" value="Dtur_1198"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1198"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1235"/>
    <dbReference type="eggNOG" id="COG4589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_2_1_0"/>
    <dbReference type="InParanoid" id="B8E2X7"/>
    <dbReference type="OMA" id="FTFDEVG"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="260" mass="29538" checksum="D43CCFF2928B5E2C" modified="2009-03-03" version="1">MLKRILTALWGIPLILWYIYLGDQVFFILVEIIACFGLYEFYNLLEKKGHKTLKLEGIIAGFLYLLFLYLETRWAMRIFLPLLILSILIYELIKKEHSIIEISLTFLGFFYIPLLLGYLIVLRNLPLGKQLTYLIILITWIGDSAAFFVGKFFGKHKLAPSISPNKTIEGSLAAIISSAIVALIFGGIYYERYFLPAILGVTLGIMGQLGDLVESMLKREIGTKDSSSLLPGHGGILDRFDSLMFIAPTTYYMLYILKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Y9</accession>
    <name>B8E2Y9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name evidence="2" type="ordered locus">Dtur_1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353103.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1210"/>
    <dbReference type="EnsemblBacteria" id="ACK42489">
        <property type="protein sequence ID" value="ACK42489"/>
        <property type="gene ID" value="Dtur_1210"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1210"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1248"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_2_1_0"/>
    <dbReference type="InParanoid" id="B8E2Y9"/>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="127" mass="14924" checksum="EF0D2B9261C5CC60" modified="2009-03-03" version="1">MKQGVIEMRQRQERLSALIRQEVSEILLRRVKDPRISSFLVITGVKMSKDLRYAHIYVSVYGSEEEKKQTMKGLESAKGFIRSELGKDLRIRFVPEIFFELDDSLEKGDRILRKLKELGLEDEEYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E314</accession>
    <name>B8E314_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAS/PAC sensor signal transduction histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583596.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353128.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1236"/>
    <dbReference type="EnsemblBacteria" id="ACK42514">
        <property type="protein sequence ID" value="ACK42514"/>
        <property type="gene ID" value="Dtur_1236"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1236"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_0"/>
    <dbReference type="InParanoid" id="B8E314"/>
    <dbReference type="OMA" id="MTETKKC"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046777">
        <property type="term" value="P:protein autophosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="126"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="350" mass="40608" checksum="211C2286A9575057" modified="2009-03-03" version="1">MKISKIEERWKVLTENVQLGILIVDKDGVVVFANNKIKELFDIQNNSKNNRKLIELIPDYEIDDLYKKTLESKTYNKTSLNFWGKEKKYLEVEAFYLSGNQEVLLIINDYTPLHRMEENFKEFLGNASHELRTPLTSIQILIDLFSEKKITLDEIYNEFFPHLRKEVERMSKLVSNLLNLSRLEAGVIDLQLKEVNLTEIVMEVIDRLTPHISKKNLEVNLKIPEKLVINADPQHLDTIVFNIVENAVKYTPQGGLIEIGVNENEDNVILWIRDTGIGIPEKDLNRIFDRFYRVSKSRTNEDGFSTGLGLSIVKKLIERHGWTIRVESKVNKGTKFEIIIPKRKEGIENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E346</accession>
    <name>B8E346_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-xylanase</fullName>
            <ecNumber evidence="4">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353534.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8E346"/>
    <dbReference type="STRING" id="515635.Dtur_1647"/>
    <dbReference type="CAZy" id="GH10">
        <property type="family name" value="Glycoside Hydrolase Family 10"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42920">
        <property type="protein sequence ID" value="ACK42920"/>
        <property type="gene ID" value="Dtur_1647"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1647"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1696"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020161_6_1_0"/>
    <dbReference type="InParanoid" id="B8E346"/>
    <dbReference type="OMA" id="PENQMKW"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="5">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="323" mass="38154" checksum="F86DF6BC936A8DDD" modified="2009-03-03" version="1">MEIPSLKEVYKDYFPIGAAVSHLNIYTYEDLLKKHFNSLTPENQMKWEVIHPKPYVYDFGPADEIVDFAMKNGMKVRGHTLVWHNQTPGWVYAGTKDEILARLKEHIYEVVGHYKGKVYAWDVVNEALSDNPNEFLRKAPWYDICGEEVIEKAFIWANEADPNAKLFYNDYNLEDPIKREKAYQLVKRLKEKGIPIHGVGIQGHWTLAWPTPKMLEDSIKRFSELGVEVQITEFDISIYYDRNENNNFKVPPDDRIEKQAQLYKQAFEILRKYRGVVTGVTFWGVADDYTWLYFWPVRGREDYPLLFDKNHNPKKAFWEIVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E369</accession>
    <name>B8E369_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ThiamineS protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584018.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353557.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1671"/>
    <dbReference type="EnsemblBacteria" id="ACK42943">
        <property type="protein sequence ID" value="ACK42943"/>
        <property type="gene ID" value="Dtur_1671"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1671"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_9_5_0"/>
    <dbReference type="OMA" id="NNEVKEM"/>
    <dbReference type="OrthoDB" id="2083208at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="65" mass="7508" checksum="6C387B5DFD6C2541" modified="2009-03-03" version="1">MRVIIRRNNEIREIKGDLKVREIFKVLNINPETALVIKGEEILTPDKIVRDDEEIEIIPVISGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E374</accession>
    <name>B8E374_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase BadF/BadG/BcrA/BcrD type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584023.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353562.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1676"/>
    <dbReference type="EnsemblBacteria" id="ACK42948">
        <property type="protein sequence ID" value="ACK42948"/>
        <property type="gene ID" value="Dtur_1676"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1676"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_1_2_0"/>
    <dbReference type="InParanoid" id="B8E374"/>
    <dbReference type="OMA" id="DTMGSMF"/>
    <dbReference type="OrthoDB" id="1589192at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="5"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="326" mass="36668" checksum="4DDC1B1449CBAC28" modified="2009-03-03" version="1">MKYFLGVDAGGTKTEAVILDGEGRIVGIGRSGPGNYEGIGVEEAKRNWILAIEKAKGERRNIEFEVACFGLAGADFPEDFIMLEKEIKELNIAKEFIVENDAPIALRAGNKEFWGVIIVMGTGNNGYGRAKNGRWYRYFGEGYIFGDWGGASSIVQEMLFHAFRSYDGRGEKTLLEDIVLNFFNEKDYVDLAKRLYYNPSEYNKALELAPLLFEAVRMGDKVAIKIVERVVDETVISAYNLMKKLDLLREETPVVLAGSVYKGAEWLPEYIQGKLRVYAEKCKVIPLKIPPAVGAVLIAYEKGGCVLTDEIWDYLWNFDYNSAIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E377</accession>
    <name>B8E377_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyruvate flavodoxin/ferredoxin oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353565.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1679"/>
    <dbReference type="EnsemblBacteria" id="ACK42951">
        <property type="protein sequence ID" value="ACK42951"/>
        <property type="gene ID" value="Dtur_1679"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1679"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1729"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_1_0_0"/>
    <dbReference type="InParanoid" id="B8E377"/>
    <dbReference type="OMA" id="GMPTRTQ"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022367">
        <property type="entry name" value="2-oxoacid/accept_OxRdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OAFO_sf"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="11"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="POR_N" evidence="3">
        <location>
            <begin position="202"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="559" mass="62844" checksum="45DE9FACFEEA493A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E386</accession>
    <name>B8E386_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1688</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353574.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1688"/>
    <dbReference type="EnsemblBacteria" id="ACK42960">
        <property type="protein sequence ID" value="ACK42960"/>
        <property type="gene ID" value="Dtur_1688"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1688"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_5_0"/>
    <dbReference type="InParanoid" id="B8E386"/>
    <dbReference type="OMA" id="LMDDIPA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
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        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
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        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="457"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="479"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="648" mass="76035" checksum="79C4ABFD6CADE5D2" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3A0</accession>
    <name>B8E3A0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate-binding CenC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584049.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353588.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1702"/>
    <dbReference type="CAZy" id="CBM22">
        <property type="family name" value="Carbohydrate-Binding Module Family 22"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42974">
        <property type="protein sequence ID" value="ACK42974"/>
        <property type="gene ID" value="Dtur_1702"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1702"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1467354_0_0_0"/>
    <dbReference type="OMA" id="MERIYNG"/>
    <dbReference type="OrthoDB" id="386120at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM-cenC" evidence="1">
        <location>
            <begin position="51"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="224" mass="25127" checksum="7D454AE24945E94C" modified="2009-03-03" version="1">MYKKLSYLLLVLFLIFVVSGCAPKETGMPIAVSQEAVKEVTKEVPNIPNAVLITTFESGKEEGWTPNGEGVSIAVVDKDTHTGKYSLYITGRKVGWNGAQIQLKDLLKPGKTYSISLWVKHNSELPQHIGITMRRRYDSDSSTQYDWISHNQETPGGKWIELSGTYQIPAGVNILDLALYVEVPSNSTLDLYIDDLVIVEGKQSFRITPELFNLFASYFKDYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3A3</accession>
    <name>B8E3A3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1705</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584052.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353591.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1705"/>
    <dbReference type="EnsemblBacteria" id="ACK42977">
        <property type="protein sequence ID" value="ACK42977"/>
        <property type="gene ID" value="Dtur_1705"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1705"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1756"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8E3A3"/>
    <dbReference type="OMA" id="LDPINTI"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="334" mass="36963" checksum="938A5BE3198062FC" modified="2009-03-03" version="1">MDKLLEVKDLKTYFILDEGTVRAVDGISFDVKPGKTLGVVGESGCGKSVTALSILKLTGPRSKIQGEILLYRDGQIIDLAKLDPKGDEIRSIRGKEIAMIFQEPGASFSPVHTVGEQIIEAIMLHQKLDKKSARDAAIELMRIAGIPRPELRVDEYPHQFSGGMLQRAMIAMALSCRPRLLIADEPTTNLDVTIQAQILELLKELQKQFGMAVMMITHNLGVIAEMAEEVIVMYLGKIVESAPVEEIFYNPMHPYTKALLESIPKIGKKVKGKRLKAIKGIVPDPYNLPTGCTFHPRCPEFVKGLCDVRVPELIEVKPGHKVSCLLYGEVKSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3C1</accession>
    <name>B8E3C1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584070.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353609.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1723"/>
    <dbReference type="CAZy" id="GH3">
        <property type="family name" value="Glycoside Hydrolase Family 3"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42995">
        <property type="protein sequence ID" value="ACK42995"/>
        <property type="gene ID" value="Dtur_1723"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1723"/>
    <dbReference type="eggNOG" id="COG1472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004542_5_1_0"/>
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    <dbReference type="OMA" id="GPEVIKD"/>
    <dbReference type="OrthoDB" id="419160at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="SSF52279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fn3_like" evidence="2">
        <location>
            <begin position="675"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="756" mass="84970" checksum="13F70BAF72D709EA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3C6</accession>
    <name>B8E3C6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584075.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353614.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1728"/>
    <dbReference type="EnsemblBacteria" id="ACK43000">
        <property type="protein sequence ID" value="ACK43000"/>
        <property type="gene ID" value="Dtur_1728"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1728"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1780"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075763_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3C6"/>
    <dbReference type="OMA" id="PLNHNRA"/>
    <dbReference type="OrthoDB" id="865801at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK43000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="319" mass="36006" checksum="2649EE11B67BC1A2" modified="2009-03-03" version="1">MNVKEIYEMFIDLGMKNDPRGWDKVQEILERAKKDYEKLSDKEKEKFDLEKLRNPYTDTRILNGDPNKEVKRVLVGIDIDTSEILLAKELGRNGKEIDLVISHHPAGYAYANFYDVMHLQEDLLAKLGVPINYAEGVLYPRILEVERKVMPANHNKSVDAARLLNIPFMCCHTPADNCVATYLQKLFDTKAPYNLQEILELLEDIPEYKEATKRNNPPKILVGNPKNRAGKIFVDMTGGTEGPVEAISKLAEIGVGTIVGMHMSEEHRKEAEKHHINVVIAGHMASDSLGMNILLDNLEKSGIEILNCSGFIRISRLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3E0</accession>
    <name>B8E3E0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584089.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353628.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1742"/>
    <dbReference type="EnsemblBacteria" id="ACK43014">
        <property type="protein sequence ID" value="ACK43014"/>
        <property type="gene ID" value="Dtur_1742"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1742"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_3_0"/>
    <dbReference type="InParanoid" id="B8E3E0"/>
    <dbReference type="OMA" id="LWYSVQS"/>
    <dbReference type="OrthoDB" id="1619224at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="292" mass="33759" checksum="8DD0F36C24C62094" modified="2009-03-03" version="1">MDKGTRRTAIFMVMPLVFVFLLLTIFPFIYMIVISFMHYNLAEWKAPYFVGLENYVKAFRDEGVHSTLEFTFLLVLLALPIEIILGGFIALFIQNLVGEKVVRSSLLLPMMIPAVVVGVIWKMLFNYEYGPVNYLLSLFGVNKIAWFGDPFFARIAVVIMDVWQWTPFIFLVLYAGLQTVPTDLIEAAKVDGGNRWVIFKYIEFPFLRPLFWILIILRLIDILRMFDIVYMTSFGGPGYATHTLSFYIYKVGISFGWDVGYASALSILLLILVTILTNILIRTMRLWEYLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3E9</accession>
    <name>B8E3E9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Glycerol-1-phosphate dehydrogenase (NAD(P)(+))</fullName>
            <ecNumber evidence="10">1.1.1.261</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.1.1.261" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584098.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353637.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1751"/>
    <dbReference type="EnsemblBacteria" id="ACK43023">
        <property type="protein sequence ID" value="ACK43023"/>
        <property type="gene ID" value="Dtur_1751"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1751"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1803"/>
    <dbReference type="eggNOG" id="COG0371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038362_1_0_0"/>
    <dbReference type="InParanoid" id="B8E3E9"/>
    <dbReference type="OMA" id="DFICRST"/>
    <dbReference type="OrthoDB" id="717704at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050492">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK43023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="399" mass="46151" checksum="7CF596B56BF5F66A" modified="2009-03-03" version="1">MLVWDKDYSKLISYIKIQKEKPFLLADENTYEVCGKEIENKLKELNINYDLLILPRDTHANEKHICKVMLYVDHHHMMVSIGAGSLTDIARFIAYKMKLKFISVPTAPSMDGYASSVAALTIEDIKTTVIAKTPKKIFANLEIIKNAPDILKRAGFGDLIGKYTALSDWKLANILIDEPLNEKVYNEMYKACENTVKSINKPDFEKLLLEALIKSGELMAIVGNSRPASGAEHHIAHYLEFLGYEIFHGIKVGISTFYVIDLYEKLLELNLDNIDEYLAYRIDIDQWKGEIKTHFPKNSERIIKENIERIKKFNDLSFRKDLIERIKLNRHKIYAIAENLLDKKEEITKACNKIGFSTNPEDWGIKKEDIKKAIQYALYIRDRFTILTLYQFLGILKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYG1</accession>
    <name>B8DYG1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HflC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">HflC and HflK could regulate a protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the band 7/mec-2 family. HflC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582429.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351957.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0002"/>
    <dbReference type="MEROPS" id="I87.001"/>
    <dbReference type="EnsemblBacteria" id="ACK41343">
        <property type="protein sequence ID" value="ACK41343"/>
        <property type="gene ID" value="Dtur_0002"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0002"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.2"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059167_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYG1"/>
    <dbReference type="OMA" id="DFFAFYR"/>
    <dbReference type="OrthoDB" id="1714999at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052547">
        <property type="term" value="P:regulation of peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03405">
        <property type="entry name" value="SPFH_HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010200">
        <property type="entry name" value="HflC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42911">
        <property type="entry name" value="PTHR42911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005651">
        <property type="entry name" value="HflC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="19"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="281" mass="32667" checksum="F044ADA261724FD4" modified="2009-03-03" version="1">MKYVYLGVILFIILFILIFSIFIVDITNQAVVLEFGKPVRVVKEPGLYFKKPFVQEVIFFEKRILQYDSEPTIVVTKDKKSMILDSFALFKIYDPILFLKTVRNELGAQARLDDIIYSEMRRVVGQYDFDDIVSKKREEVFEEITISSREKAKELGIEISTVRMKRVSVPAENLKKIYDSMTAERQRQAALYRAEGQREAQRIKSEAEKKRVIILSEAYRKAQELKGKGEAEASKILQTALSSDPEFYQFLKTLELYKSTLPGNVLIITPDSELFKYLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYG8</accession>
    <name>B8DYG8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0009</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582436.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351964.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0009"/>
    <dbReference type="EnsemblBacteria" id="ACK41350">
        <property type="protein sequence ID" value="ACK41350"/>
        <property type="gene ID" value="Dtur_0009"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0009"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1021886_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYG8"/>
    <dbReference type="OMA" id="CFITISI"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="6">
        <location>
            <begin position="22"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="232" mass="25855" checksum="1DECC9FF24615345" modified="2009-03-03" version="1">MSTFVFIYKSLNVPDFAYAFVILGGAMIAYWLNILWSMASQLYWERMTGNLPIFFIAPCSINSILIGMALGGMVAASVRAISILILGILIFKIPVDFSNLSSALFIFSITLIALYGLGMMLSSVFLLSGREAWHLASLLQEPIYLFSGFFFPVKVFPFIISFLSSLLPTTLGLDALRQTLILGSKPFAFLTVELETVILLFLSGIYIGGSFYLAKRIETIARREGRLIVRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYJ1</accession>
    <name>B8DYJ1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fructose-1,6-bisphosphate aldolase, class II</fullName>
            <ecNumber evidence="4">4.1.2.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582459.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351987.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0035"/>
    <dbReference type="EnsemblBacteria" id="ACK41373">
        <property type="protein sequence ID" value="ACK41373"/>
        <property type="gene ID" value="Dtur_0035"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0035"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.36"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040088_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYJ1"/>
    <dbReference type="OMA" id="PRTWGKL"/>
    <dbReference type="OrthoDB" id="827430at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011289">
        <property type="entry name" value="Fruc_bis_ald_class-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00167">
        <property type="entry name" value="cbbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01859">
        <property type="entry name" value="fruc_bis_ald"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="212"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dihydroxyacetone phosphate binding" evidence="2">
        <location>
            <begin position="254"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="309" mass="34040" checksum="BC1972009DE7C721" modified="2009-03-03" version="1">MPLVNPKELFQKCYGKYAIGAFNVNNMEILQGVIEAAKEERSPLILQISKGARNYAKLIYLMKLIEAAVQDAPDIPIVVHLDHGDSVELCKEVIDAGFTSVMIDGSHLPFEENVRITKEVVDYAHPRGVAVEGELGRLVGVEEHVVVSEREASFTDPDKAVEFVERTGVDSLAIAIGTSHGAYKFKGEPKLDFDRLREIAKRLPGFPLVLHGASSVLPEYVEKANQYGAKLGGAKGVPEEMIREATKMGICKVNIDTDLRLAVTATIREVFALHPEEFDPRKYLGPAREEVKKLVKHKLRNVLGSSGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYJ9</accession>
    <name>B8DYJ9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase M23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582467.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351995.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0043"/>
    <dbReference type="MEROPS" id="M23.009"/>
    <dbReference type="EnsemblBacteria" id="ACK41381">
        <property type="protein sequence ID" value="ACK41381"/>
        <property type="gene ID" value="Dtur_0043"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0043"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_2_4_0"/>
    <dbReference type="InParanoid" id="B8DYJ9"/>
    <dbReference type="OMA" id="DHGYGIK"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="196"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="305" mass="34901" checksum="0EF2B9883638BF7C" modified="2009-03-03" version="1">MAKKRKWWKRKFFTIMIIPHDASNAKSRRIHISLILIIIFAIIGIISTSLTLYRIANNRFNKVKHLEVLEEVTEQQRAQLKEIEVLRQKLKELEEMEKKIKNLLGIKGMIPPPKDIKMVSLGTNSIPDNETYDIQRKIVEVKTLIEEKQKVLLQIEKEIDRRKTLLAVTPSRWPTFGFISSGFGWRFHPIFRRMAFHTGIDIVTFWGAPVYATADGIVSFVGWESGYGKVIKINHGRGIITYYAHLSSYAVRVGQFVKKGQFIGRVGSTGTSIGPHLHYEVRRGGSPVNPSAYLSVDLIKIGKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYM5</accession>
    <name>B8DYM5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582493.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352021.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0069"/>
    <dbReference type="EnsemblBacteria" id="ACK41407">
        <property type="protein sequence ID" value="ACK41407"/>
        <property type="gene ID" value="Dtur_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0069"/>
    <dbReference type="HOGENOM" id="CLU_1755931_0_0_0"/>
    <dbReference type="OMA" id="NECRREF"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="148" mass="18561" checksum="0EE7AAB67A987748" modified="2009-03-03" version="1">MNCKEFREKMFLHEEIGEDFFLHLEECNECRREFEDFLRIEEKLKERVFEEESGKEWSRVYKSVYNRLMYEKIKRRVFIFLLVSLEIILLSLIFFFVYRVGRFFLQDFLLLSFMLNSLFQILFQVNFYLFLFTLLLFIYQNGLHRKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYP2</accession>
    <name>B8DYP2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582510.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352038.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0086"/>
    <dbReference type="EnsemblBacteria" id="ACK41424">
        <property type="protein sequence ID" value="ACK41424"/>
        <property type="gene ID" value="Dtur_0086"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0086"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8DYP2"/>
    <dbReference type="OMA" id="TTRMAIM"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="326" mass="36675" checksum="6A40BA2EDB293BA6" modified="2009-03-03" version="1">MSIILKTENLKAFYILKYLGEERVIKAVNGINLEIPENEIYGIAGESGCGKSTLLKVLLATLDPPLKHIDGSLYYNFDNNFIDVLRSPKEELKKFRWKFISYIPQGSMHVLNPVKKVKDTFLEFLESHVKEKDKKDYLELSIEHLRELGLSPETLEAYPHQLSGGMRQRVVIALSTLLHPQIILADEPTTALDVVAQRAVIQLLKRIQNTLQNTIIIVTHDMGIHAQITTKMAIMYAGKIVESASTKEIFKNPLHPYTKYLIQSLPHIGDKEPREGIQGSPPSLISLPPGCAFHPRCPYAQPICKSEEPTLKEVSSEHKVACFIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYR2</accession>
    <name>B8DYR2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582530.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352058.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0110"/>
    <dbReference type="EnsemblBacteria" id="ACK41444">
        <property type="protein sequence ID" value="ACK41444"/>
        <property type="gene ID" value="Dtur_0110"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0110"/>
    <dbReference type="eggNOG" id="COG5114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036791_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYR2"/>
    <dbReference type="OMA" id="CENAMIL"/>
    <dbReference type="OrthoDB" id="233805at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="483" mass="57581" checksum="CFC91B764F0621F0" modified="2009-03-03" version="1">MPSKIPHINRIISTYGSYAKPFLNWALEMAKIPPPWKHYFIALKFYWKREYFLSLAELEKALDKCNSNKTLYYLILTEKLSILSNINSREGNAIYEKLKREFPYIPSYVRNIASPSLLHYYATNFPSNLRKFRIWSNKYPLDPSSKTFILLGKAREEIKGKNIRKAISYYSEAFRTSLSIPHPTGIINSLNDASWYLKEKHPKFSLLLAKKAVYYSAWYREDLSYGFAVLDTLFEVQRINNDPSICETSMIIQHYYKSLPNSSGKYTKEHYKKLFEFSKKFCFNLEASFYENDGKRINIFENFQKSIEILNSMSKNKREILILSTFMSICNRKMLFPFISKNLKNILAYSESIKKIINLANKNFEIIRFLSYISTDHPFLKARKDLATKFLETLHPNKKEFFISFYLSLKEKEREFIDTFIRNYVRYDRDWNIKIHTPEEIIPFIKKFQLKELPSSLAYFSFEKRERREFDSLINHIYSLFID</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYU2</accession>
    <name>B8DYU2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-alkenal reductase</fullName>
            <ecNumber evidence="2">1.3.1.74</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="1.3.1.74" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582559.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352088.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0143"/>
    <dbReference type="EnsemblBacteria" id="ACK41474">
        <property type="protein sequence ID" value="ACK41474"/>
        <property type="gene ID" value="Dtur_0143"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0143"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.149"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_2_2_0"/>
    <dbReference type="InParanoid" id="B8DYU2"/>
    <dbReference type="OMA" id="THGWVLE"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032440">
        <property type="term" value="F:2-alkenal reductase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="230"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="318" mass="34361" checksum="3E9AC3809718BF72" modified="2009-03-03" version="1">MEDYERILEDYSNALVKVVEKVSPAVVNLDLSQSTFIPFFFGPQEIKGFASGFLFTPDGYILTNSHVTHQASKIQITLADRRTYQAELVGEDPQTDLAVIKIHENNLPYLELGDSEKLKVGQIVLAIGNPLGFGHSVTSGVISALGRSLRSFSGHLMENIIQTDAALNPGSSGGPLVDIHGRAIGVNTAIIQGAQGICFAIPINTAKWVAGLLIKEGRVRRSYLGIIGQSVVLPKRLRENLSLSQEGGVYILRVAPGSPAQRGGINSGDIIIQAENEIINNIDDLHRFLSHTPPGSRVAVRVIRDNNIKEISIVLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYU9</accession>
    <name>B8DYU9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582566.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352095.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0150"/>
    <dbReference type="EnsemblBacteria" id="ACK41481">
        <property type="protein sequence ID" value="ACK41481"/>
        <property type="gene ID" value="Dtur_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0150"/>
    <dbReference type="eggNOG" id="COG5375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1486812_0_0_0"/>
    <dbReference type="OMA" id="IAPEGIW"/>
    <dbReference type="OrthoDB" id="1940176at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="181" mass="20775" checksum="9654FF766E37FBE8" modified="2009-03-03" version="1">MKRIILLGIFILVGLVAWGTSYYFVPLEKEVSNTNLEKAGIYAEKVYLKGRSEGNLSWEVSADNLNIDLNYKHFVFEGDVKGKVYRDKKLSLLIITKRAEIDRDKNILKIPTELHFETEDGFKGIAPEGIWYFDTGIFMSTKGRVKFEKVGEFKAEADMFVFDTNKGKAEFEGNVVIETYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYW6</accession>
    <name>B8DYW6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582677.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352206.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41592">
        <property type="protein sequence ID" value="ACK41592"/>
        <property type="gene ID" value="Dtur_0266"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0266"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.279"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056905_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYW6"/>
    <dbReference type="OMA" id="FLPHYGL"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045761">
        <property type="entry name" value="ODP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19583">
        <property type="entry name" value="ODP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="24"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="374" mass="43341" checksum="5378D924891AD517" modified="2009-03-03" version="1">MSEIKTYEIEKGLYLFKDPEPFFNFNSYLLTCSMDDKVSINILFDPLPLKYFRAFIKTLNELVGVENIDIIYTNHQDPDLTSSVPALLDLAPRAIYITSQDTWRLVSGYNIDPKKFQPVEFIPNRKLKLNKEGDMCLEFIPTPFCHFRGATAVYYPKLKALFSGDLLGGASTKDTEGIYATEESWLGIKLFHEVYMPTKEALKLAVDKIGRLNPLPELILPQHGDIIKGSLIIEFLSRLNDLEVGLDYIHTKEKEEEFYIRVFNDMLDFAKKKYGEENVYNKLNRISTQTSNFPEIVKIENGVISEVYIPAPTAFVFVYDVFCEDLPESEKEELRLKSIETLKKYNLEVPEELLYKKSTSIMDTFKRVFDIFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYX1</accession>
    <name>B8DYX1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MgtC/SapB transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0271</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582682.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352211.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0271"/>
    <dbReference type="EnsemblBacteria" id="ACK41597">
        <property type="protein sequence ID" value="ACK41597"/>
        <property type="gene ID" value="Dtur_0271"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0271"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.284"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYX1"/>
    <dbReference type="OMA" id="AANLWLT"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="8">
        <location>
            <begin position="143"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="215" mass="23076" checksum="94C8247E78809834" modified="2009-03-03" version="1">MINVWDVLLRFILSTLFSGVIGWEREKEEKPAGLRTHILVSLGSTLFMIVSAYAFPGNGDPGRIAAQVVTGIGFIGAGTILRTGFTVKGLTTAASIWAVSGIGLSVGAGLYFPAFIATIFIIVVLVLATKLEKIFLGTHQDVGLNLIIEDRPGAIGEIGTLLGELNVDIKQIELGNSWEGKISLKILVRIPQKLTKNELLLRLSDLPSVVDVELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ01</accession>
    <name>B8DZ01_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin-dependent glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582712.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352241.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0305"/>
    <dbReference type="EnsemblBacteria" id="ACK41627">
        <property type="protein sequence ID" value="ACK41627"/>
        <property type="gene ID" value="Dtur_0305"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0305"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.321"/>
    <dbReference type="eggNOG" id="COG1304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521509_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ01"/>
    <dbReference type="OMA" id="QMNVEDT"/>
    <dbReference type="OrthoDB" id="151647at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glu_synthase" evidence="2">
        <location>
            <begin position="277"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="522" mass="57684" checksum="99E7219BE37D09AE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ06</accession>
    <name>B8DZ06_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582717.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352246.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0310"/>
    <dbReference type="EnsemblBacteria" id="ACK41632">
        <property type="protein sequence ID" value="ACK41632"/>
        <property type="gene ID" value="Dtur_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0310"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021021_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZ06"/>
    <dbReference type="OMA" id="DPHIYCL"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="566" mass="65306" checksum="6BDFBBB6E95E8C1B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ18</accession>
    <name>B8DZ18_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0327</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582729.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352258.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0327"/>
    <dbReference type="EnsemblBacteria" id="ACK41644">
        <property type="protein sequence ID" value="ACK41644"/>
        <property type="gene ID" value="Dtur_0327"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0327"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.348"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_2_2_0"/>
    <dbReference type="InParanoid" id="B8DZ18"/>
    <dbReference type="OMA" id="SYCYVRQ"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="16"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="281" mass="33072" checksum="1571E5AEDCC11B27" modified="2009-03-03" version="1">MVIKEITCKTAISKCGFPSGGWAINPYVGCAHGCLYCYARFMKRFTKHTEGWGEFVDIRVNMPEVLKKEIKREKYKNGNINIGTVTDPYQPLEEKYEITRKILEILSEYPYPLSILTKSDLVLRDIDLIKKFKNIDVNITLNTLDEDWKRVVEPNSPSIERRIYTIERLKQENIKVYVMMGPFWPFFSDAEELIKTFKVLGIEEIYTESFNTRGGTFSEIERLMSQHYPNLLPRMKEILFDKENFNNFYSLVKENLLELAKQYNIKINIYFGRGHAKFHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ62</accession>
    <name>B8DZ62_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582773.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352302.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0384"/>
    <dbReference type="CAZy" id="GH4">
        <property type="family name" value="Glycoside Hydrolase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41688">
        <property type="protein sequence ID" value="ACK41688"/>
        <property type="gene ID" value="Dtur_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0384"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.404"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZ62"/>
    <dbReference type="OMA" id="YVPWYLH"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="192"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="441" mass="50888" checksum="DF351BCF29EF2825" modified="2009-03-03" version="1">MKISFIGAGSVVFTRNLLRDLALFSEFDETEIALMDIDPERLEVAKKIAEEIKEKKNKNWNIKGYMDLKSAIENSKYVINTVQIGGKSATYVDFDIPEKYGLKQTIGDTHGIGGIMRFLRTAPFLRELTRNIEEYAPSALLLNFTNPMSMNQWYINDISEIDTVGLCHSIPYTIEQISSYVGVPSKEVNYKVAGINHMAWVLVFERNGEDLYPLLFKAMEKKEIWEKDPVRFEILRMFHYFVTESSEHNAEYVPYFIKDEELVKKLNIPIREYIRRVEENEKVFDAFRDYYLRGNKEAYGVVKEHYGDEDDDASKEYAIQIIHGIETNNSKLVYSIVRNDGIIDNLPMDCMVEVPCYVDRNGVSPLKIGYLPDQLASLNLSHINVQRLAVKGAIEGDKDYIHYAALLDPLASSLLSPEKIHMMVEELLKAHEEYLKDLFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ76</accession>
    <name>B8DZ76_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352423.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41809">
        <property type="protein sequence ID" value="ACK41809"/>
        <property type="gene ID" value="Dtur_0516"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0516"/>
    <dbReference type="HOGENOM" id="CLU_157823_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ76"/>
    <dbReference type="OMA" id="WAGFQAP"/>
    <dbReference type="OrthoDB" id="2142331at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="132" mass="15887" checksum="C48952D34916774C" modified="2009-03-03" version="1">MINYLFWIISSGITIYLLLYSRGFYLKVFSFLMRDFYLINVIDKFLFIALSFIALGFIVYLESFYRKNKKVFYKFLLITGIQLIILFVFQFTPYLLFGIVLSYKEIFFLILEIILGGFFIGIYISNQRYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ90</accession>
    <name>B8DZ90_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582908.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352437.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0533"/>
    <dbReference type="EnsemblBacteria" id="ACK41823">
        <property type="protein sequence ID" value="ACK41823"/>
        <property type="gene ID" value="Dtur_0533"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0533"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZ90"/>
    <dbReference type="OMA" id="NMAYFTP"/>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="PTHR23264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="272" mass="29522" checksum="12451B22A3259AF3" modified="2009-03-03" version="1">MRNEDILKQKEKINERMSKIKNKIVVMSGKGGVGKSTVAVNLAISFALRGYKVGLLDADITGYSVPKLLNLTSERLYNADDGILPAETNMGIKVASAGFLVENEEAPIIWRGPLKVSLIREFLSSIIWGDLDYLIIDLPPGTGDEPLSIAQDIPDISGAVIVTIPSDLSQKVVRRAVNFAKALNMPIIGIIENMSGFVCPHCGARVDIFSKGGGEKIAKDLNVPLLGKIPLDPRVAESGDNGIPFIITHKDSEVSKVFMEIVEKIENFLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZD5</accession>
    <name>B8DZD5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582953.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352482.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0580"/>
    <dbReference type="EnsemblBacteria" id="ACK41868">
        <property type="protein sequence ID" value="ACK41868"/>
        <property type="gene ID" value="Dtur_0580"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0580"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072983_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZD5"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' exodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="244" mass="28331" checksum="19830ECD9549747B" modified="2009-03-03" version="1">MKAICHIHTKYSFDGMMSPSKIVEYAKRRVINILLICDHDSFEGARQALDYAYSKKIDIYIPFSAEIKTEYGDIIVVLNDFDENLNISELKKFETLIHVVKNKGGVIILPHPYCQHRDIERIAMKVDCIEVFNSRCSEQQNQKALNLCMQLNKVPIYGADAHLFSELDNVIVSYSNFDRNFPFLSSSVLLAGRQTQNYKIRISSLIKAVRKRNFYEIVNLTLSMIKWLLIEEIFANRRKNIGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZF2</accession>
    <name>B8DZF2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582970.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352499.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0597"/>
    <dbReference type="EnsemblBacteria" id="ACK41885">
        <property type="protein sequence ID" value="ACK41885"/>
        <property type="gene ID" value="Dtur_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0597"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151920_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="6"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="140" mass="16152" checksum="7B18572B97EBFAEC" modified="2009-03-03" version="1">MRFLTLDSSIIIAALREQEEKHDICLGVLEKIKNGEYIAIEPYIVLIEVTAAIRRRTGSKKLAEKVRFYLKDIDSIHFLELESYRAEEASKVAEELSVRRMNAIVIQIAKEFNSVLLTLDNEMAEKAKDFVYIGKIEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZI3</accession>
    <name>B8DZI3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583001.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352530.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DZI3"/>
    <dbReference type="STRING" id="515635.Dtur_0628"/>
    <dbReference type="CAZy" id="GH12">
        <property type="family name" value="Glycoside Hydrolase Family 12"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41916">
        <property type="protein sequence ID" value="ACK41916"/>
        <property type="gene ID" value="Dtur_0628"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0628"/>
    <dbReference type="eggNOG" id="ENOG5033TC2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075480_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZI3"/>
    <dbReference type="OMA" id="WVHGYPE"/>
    <dbReference type="OrthoDB" id="797310at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="288" mass="33795" checksum="7FEE6F98EE4E1379" modified="2009-03-03" version="1">MKKYLLLIVFLLLLITLSFSQTPKYKDAFILKEPSSGDVITKNLPLTIELNFWNIAKYEGNTWMAFYKEEDAVEYYADIKNIILKDKNSWVHGYPEVYYGYKPWSAHGNSIEKLVLPRKVLEFPDVLFNLKYNIWYERNLSINFAMETWITKEPYQKTVTAGDIEMMVWLYANRLSPAGRKVAEVKIPIILNGNQKDIVWEVYFSPGSWDYIAYKSKENIIQGEVKIPIKDFIKHLRTVIANNSSRITAEKYDQMYVTVWEIGTEFGDPYTNEAKFGWTFSNFNIESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZJ7</accession>
    <name>B8DZJ7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583015.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352544.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0645"/>
    <dbReference type="EnsemblBacteria" id="ACK41930">
        <property type="protein sequence ID" value="ACK41930"/>
        <property type="gene ID" value="Dtur_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0645"/>
    <dbReference type="HOGENOM" id="CLU_1000151_0_0_0"/>
    <dbReference type="OMA" id="PNKMNKF"/>
    <dbReference type="OrthoDB" id="2115090at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="282" mass="31697" checksum="364D96662F3F741C" modified="2009-03-03" version="1">MKKFIVLMLIIFFVFFVSGCVKQEPQADKDLSSTELNNIYDLVNSGEYNKSIQIYMSDLPGNLWPTSPVSKPELSKLIEKAPMAKSIDKVSIELNWQGPDADGWYTLTLDSSSYLKIRYYSSLKKLELKAYLDSTDTLRFVVVEEGYFVFNKNIRVDTINVYPVSGKFSFYFLAPSKNDPNKMNKFGLTLSWDDISITCLSQFNNIGILTGSMGLYMTYVDYDQNINVNNKLMANFTSSVNGADTTDPILIISGTKDSDGDPTTDGYDNFDLELPLADLLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZN0</accession>
    <name>B8DZN0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M78 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583048.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352577.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0678"/>
    <dbReference type="EnsemblBacteria" id="ACK41963">
        <property type="protein sequence ID" value="ACK41963"/>
        <property type="gene ID" value="Dtur_0678"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0678"/>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084682_3_0_0"/>
    <dbReference type="InParanoid" id="B8DZN0"/>
    <dbReference type="OMA" id="NALHHPN"/>
    <dbReference type="OrthoDB" id="1840229at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="147" mass="17334" checksum="FF2FC84F0D179F57" modified="2009-03-03" version="1">MYEELIKELLSLFYINKPPIKPEIIAYGLGVELYFYELPLQISGILYNRKNSPTMLINKNDNLLRQRFTIAHEIGHFLLHYSNNKIYLDYPIENSKIEREANTFAASLLLPDFLLGRYLNLSLEKISSIFYVSRKVTEIRLKDFKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZQ3</accession>
    <name>B8DZQ3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative circadian clock protein, KaiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583071.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352600.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0701"/>
    <dbReference type="EnsemblBacteria" id="ACK41986">
        <property type="protein sequence ID" value="ACK41986"/>
        <property type="gene ID" value="Dtur_0701"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0701"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.739"/>
    <dbReference type="eggNOG" id="COG0467">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975202_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZQ3"/>
    <dbReference type="OMA" id="FSQQFLW"/>
    <dbReference type="OrthoDB" id="1168846at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022373">
        <property type="entry name" value="KaiC_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03878">
        <property type="entry name" value="thermo_KaiC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51146">
        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="34"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="303" mass="33742" checksum="356F4B399D500327" modified="2009-03-03" version="1">MEKEERSYQQTQYEVVEDAILSLKDIGDRAVEIRGIPTGIEGLDNLFFTTKIEKGKTRVVPLGGIPQYSVFNLTGISDTGKSLMGEQFAIKQASLGNAVAFITVESPAHFVATSMKSRAAAMGVEESVIDENIVFIDAASYSKLREDVPTLLATLAHAIKKYKIKYTVIDSITGLYEAKEMMARIIVRQLFNFMKKWYQTAIFISQKRSSQEEFSAEAAGGFAISHIVDGTMVLSKVLISSQYMERMYKRPMGELVRLFRIDGCRMCGHSTDTYLLEIDRNGLVRIGQSLKELSKGVKADANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZS8</accession>
    <name>B8DZS8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583096.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352625.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0728"/>
    <dbReference type="EnsemblBacteria" id="ACK42011">
        <property type="protein sequence ID" value="ACK42011"/>
        <property type="gene ID" value="Dtur_0728"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0728"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="InParanoid" id="B8DZS8"/>
    <dbReference type="OMA" id="RFFAEPY"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50932">
        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="337" mass="38028" checksum="887717B765C85B32" modified="2009-03-03" version="1">MTKKKKAPTSWDVARLAGVSRSTVSFVLNNTPGIKISEETRRRVLEAVKALDYKPNAIARSLAKQKTEAIAFFVLDIANPVFPNMARGIEDVARQNGYTLFLCNTDGKTLREVRYMNIMLERRVDGIIAGALSNEEVSKIAQKKNIPLVILEHPRLPEHDVVYADNVKGSYEAVMHFVELGHKRIAHITINPESIIVQERIEGYKKALEDAGIPFDDNLLKIFYDKVDEEKAINELFSLPDPPTAIFTFSDFMAIQVMKILIRRGYRIPEDVSVIGFDDTLANLTIPALTTVSQPFYEMGAKAAEILIERLKNPNMPIQHIKLPTKLVIRESTAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZU9</accession>
    <name>B8DZU9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583117.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352646.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42032">
        <property type="protein sequence ID" value="ACK42032"/>
        <property type="gene ID" value="Dtur_0750"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0750"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.788"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042889_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZU9"/>
    <dbReference type="OMA" id="AHYFMPL"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023980">
        <property type="entry name" value="CHP04013_B12-bd/rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04013">
        <property type="entry name" value="B12_SAM_MJ_1487"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="148"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="405" mass="46726" checksum="4F6C2EF8772A5270" modified="2009-03-03" version="1">MKYKIVFYDVKENKYSINALLGALEKDFKNFEIGFVEKSQVDFWLENIEKDVFYIFCVSFFTTQFFETEALLKRIKEKIENVKIIAGGPHASGDPYSTLKIGADIVVVGEGEKIFPEIIKRIISGEDVKGIFKGESFVKLDDYFPFSLRFKRFGPIEISRGCPYGCYFCQTPRIFGGVMRHRSTEKILDIVKIMNKLNLKDIRFITPNAFAYGSLTGKDVNLRRLEELLYGIRNIIGDKGRIFFGSFPSEVRPEHVREEILELLKTYADNDNLVIGAQSGSQRILDLAHRGHTVEDVYRAVSLTLRYGLKANVDFIFGLPYEEERDIEETLKFIEELVKMGARVHAHTFMPLPGTPFAKFPPGKLEGMYKKIINRLLPKGVIFGNFREQEKVAWEIYNYFSLREE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZY2</accession>
    <name>RL25_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplY</name>
        <name evidence="1" type="synonym">ctc</name>
        <name type="ordered locus">Dtur_0784</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583150.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352679.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZY2"/>
    <dbReference type="SMR" id="B8DZY2"/>
    <dbReference type="STRING" id="515635.Dtur_0784"/>
    <dbReference type="EnsemblBacteria" id="ACK42065">
        <property type="protein sequence ID" value="ACK42065"/>
        <property type="gene ID" value="Dtur_0784"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0784"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075939_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZY2"/>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000142519" description="50S ribosomal protein L25">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <sequence length="207" mass="23237" checksum="481F2350743635D3" modified="2009-03-03" version="1">MEITEIKVKKRDKIGKQFAKKYRRSNLIPGVVYGAHLKENIHILVEKKDLWSLIKKGHAKEQHLLRLIIENGENTITENAILQDLQIDPIKDEFLHVDFHAITLEELVDVYVPILLVGEAKGIKQGGILQHGVEEILIRALPLDVPPHIEVDITDLEIGESITVGDLKFPENIKVLTPLDEVVVGIIPPKGYTEEVTTGEAQTESQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZZ7</accession>
    <name>B8DZZ7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583165.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352694.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0799"/>
    <dbReference type="EnsemblBacteria" id="ACK42080">
        <property type="protein sequence ID" value="ACK42080"/>
        <property type="gene ID" value="Dtur_0799"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0799"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.837"/>
    <dbReference type="eggNOG" id="COG1692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068238_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZZ7"/>
    <dbReference type="OMA" id="NHIWDKK"/>
    <dbReference type="OrthoDB" id="1127353at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00282">
        <property type="entry name" value="TIGR00282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="262" mass="29214" checksum="03B1353DCF8341AE" modified="2009-03-03" version="1">MNILFLGDIVGRIGRRGVGLLLPQIKKEFNIDLVVANIENAASGFGITESVVKELFEYGIDVFTSGNHIWDKKEGIPLLDIYERILRPANYPLGVPGRGYLVLTHMDKKVGIINIQGRIFMEPIENPFYVVKNIVEEMKKDTKIIIVDVHAEATSEKIAMGYFLDGMVTAVVGTHTHVQTADERILPGGTGYITDLGMCGAYDSILGVEKEAVLKKFLLQIPQKFNVPEKGLFKMEGVIIEVEEESGKTKNIIRLQRRGEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8E010</accession>
    <name>B8E010_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="7">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murA</name>
        <name evidence="9" type="ordered locus">Dtur_0812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583177.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352707.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0812"/>
    <dbReference type="EnsemblBacteria" id="ACK42093">
        <property type="protein sequence ID" value="ACK42093"/>
        <property type="gene ID" value="Dtur_0812"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0812"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.850"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
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    <dbReference type="InParanoid" id="B8E010"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="8">
        <location>
            <begin position="15"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate binding" evidence="7">
        <location>
            <begin position="30"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-N-acetylglucosamine binding" evidence="7">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="433" mass="47163" checksum="0286D65677C55902" modified="2009-03-03" version="1">MVGDLHVRKDKFVIEGGHKLRGELEIWGSKNASLPIMAASVLNSGDLILDNVPPVKDNITMAEILKVLGMEVEFLEGDKVHIKGEPKGYRAPYELVSKMRASFELMGPLLARFGEAEIPYPGGCRIGLRPVDLHIKGFESLGAEVTVEKGYVCARAKKGLKGTKIHLDKPSVGATRNIMMAAIMAEGETVIENAACEPEVVDLGNFLKMMGAEIEGLGTSTIYIKGKKDLKPVDYYKVIPDRIAAGTFIIAGVMLGKDLIIKNVEPEHLQSLFIKLKEAGVESFQIKDKEVRIKAAKNWKGIEVTTMPYPGFPTDLQPQMMVFLSLAQGSSLIVETVFENRFLHVGELLRLGAKISIDGRTALIQGVEKLKGAPVEVTDLRAGAALVLAGLVAEGTTEVLDVGEHIDRGYVALEDKLSNLGAKIKRVYYEEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E059</accession>
    <name>B8E059_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylglyoxal synthase</fullName>
            <shortName evidence="1">MGS</shortName>
            <ecNumber evidence="1">4.2.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mgsA</name>
        <name evidence="4" type="ordered locus">Dtur_0861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate = methylglyoxal + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17937"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="EC" id="4.2.3.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylglyoxal synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.3" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583226.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352756.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0861"/>
    <dbReference type="EnsemblBacteria" id="ACK42142">
        <property type="protein sequence ID" value="ACK42142"/>
        <property type="gene ID" value="Dtur_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0861"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.900"/>
    <dbReference type="eggNOG" id="COG1803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120420_0_1_0"/>
    <dbReference type="InParanoid" id="B8E059"/>
    <dbReference type="OMA" id="RACDVHN"/>
    <dbReference type="OrthoDB" id="1726279at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008929">
        <property type="term" value="F:methylglyoxal synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019242">
        <property type="term" value="P:methylglyoxal biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01422">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00549">
        <property type="entry name" value="Methylglyoxal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004363">
        <property type="entry name" value="Methylgl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018148">
        <property type="entry name" value="Methylglyoxal_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30492">
        <property type="entry name" value="PTHR30492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006614">
        <property type="entry name" value="Methylglyox_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00160">
        <property type="entry name" value="MGSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01335">
        <property type="entry name" value="METHYLGLYOXAL_SYNTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MGS-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="45"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1 2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006614-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="153" mass="17332" checksum="E9F9E0C618F754B8" modified="2009-03-03" version="1">MGYREIIMGKQKRIALVAHDNKKQELLEWAKFNKGTLANHILYATGTTGDIIERELGLKVIKFYSGPLGGDQQIGAKIAEGEIDFLIFFWDPLEPLPHDPDVKALLRIAVVWNIPIASNRATADFIISSPLMNTEYVRLVPDYQGYIHRKINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8E087</accession>
    <name>B8E087_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583614.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353146.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1254"/>
    <dbReference type="EnsemblBacteria" id="ACK42532">
        <property type="protein sequence ID" value="ACK42532"/>
        <property type="gene ID" value="Dtur_1254"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1254"/>
    <dbReference type="HOGENOM" id="CLU_2287001_0_0_0"/>
    <dbReference type="OMA" id="VEFRIYD"/>
    <dbReference type="OrthoDB" id="2151890at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="101" mass="12031" checksum="45D3FB4A81009D12" modified="2009-03-03" version="1">MKQFLSILFFFLLFLSTVFLNIKVSALRSEIKKVINEIDILEKEKTYLENYIQSNLDLKKIEKKALEMGLVYPKNVVEFRIYNGRISEINKEKYYALSLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E098</accession>
    <name>B8E098_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583625.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353157.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1265"/>
    <dbReference type="EnsemblBacteria" id="ACK42543">
        <property type="protein sequence ID" value="ACK42543"/>
        <property type="gene ID" value="Dtur_1265"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1265"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1305"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_0"/>
    <dbReference type="InParanoid" id="B8E098"/>
    <dbReference type="OMA" id="DFHDLCE"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="1">
        <location>
            <begin position="249"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="334" mass="39291" checksum="EF7A7F81C5EA360C" modified="2009-03-03" version="1">MANLIIGESQSGKTTFLKVLSKGRAHLKFSDINVCAVPKEDYRLIQLWKTFNSKSINFINMDFIDLPGNAKLSSLTPQFYERIQKSEILFYIIPLFREDLDIKNYTNNEQNEIILRDLEICERLLKNRKLNMAEKSVLEKIQKNLLEEKPLNEIELREDELKIISSWNFISIKPIFYVINVSNNQLEDSKFIEEIKNKLKNKIYFIFPAQLEEEIMELSEDEVKEYLSIYNLKDPIRNQVLDKIFEYNDLISFFTAGEKEARAWKLKKGSTALEAAGTIHSDIARGFIRAEVIRWDELVQIGDWKKAYQEGKVRIEKKDYIVQDGDVIYIRFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0A8</accession>
    <name>B8E0A8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583635.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353167.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1275"/>
    <dbReference type="EnsemblBacteria" id="ACK42553">
        <property type="protein sequence ID" value="ACK42553"/>
        <property type="gene ID" value="Dtur_1275"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1275"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1315"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_0"/>
    <dbReference type="InParanoid" id="B8E0A8"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="343" mass="40410" checksum="03298AFB631701DB" modified="2009-03-03" version="1">MDVNEIQKFLLIIENKLQENWNKFSSNISIHLITAYHMGWVGEDLTPLANIRRGKRLRPLFCVLVNQTLGGFLDDALEIGSAIEFLHNFSLVHDDIQDRDEKRHGRWTVWKIWGEAQAINVGDLLFNMVFQVLTNLKSPVLLSKSLKELTETIRELIEGQYLDISFEKRKDISLKEYLMMIDKKTAKLFSTSFYLGAFSATYKEDLSKIFQEIGRDFGLFFQIADDAIGIWGDPEKTGKNAFVDLWRKKKTYPILYLYSESSEKEKLRIEEIWGREIVTEKDIEYLLDHLERKRVKEATFNLAEKYFDEGYKKLLSFQDLYNISLLRKLFEDYYNLIFSLQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0E3</accession>
    <name>B8E0E3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">infC</name>
        <name evidence="8" type="ordered locus">Dtur_1314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583670.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353202.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1314"/>
    <dbReference type="EnsemblBacteria" id="ACK42588">
        <property type="protein sequence ID" value="ACK42588"/>
        <property type="gene ID" value="Dtur_1314"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1314"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1359"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0E3"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="OrthoDB" id="1760144at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IF3_N" evidence="7">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="IF3_C" evidence="6">
        <location>
            <begin position="85"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="185" mass="21495" checksum="FF8359324C425CB5" modified="2009-03-03" version="1">MDKDYRVNEKIRAREIRVVDEDGKQLGIMPVSEALKLARERNLDLVEVAPNANPPVCKIMDFGKFKYELARKEKEAKKNQKIASEVKEIKIRPNIEEHDYQVKLRKIREFLEKGYKVRLIILFKGRQLIYNEWGDKLLERILQDISDLGTAEKKGQQVGMSLVTMLIPGKKTSTKKAVLEEVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0H8</accession>
    <name>B8E0H8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ordered locus">Dtur_1349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583704.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353237.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1349"/>
    <dbReference type="EnsemblBacteria" id="ACK42623">
        <property type="protein sequence ID" value="ACK42623"/>
        <property type="gene ID" value="Dtur_1349"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1349"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1394"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_0_2_0"/>
    <dbReference type="InParanoid" id="B8E0H8"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="40"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="265" mass="29834" checksum="EB83275FE3DA6077" modified="2009-03-03" version="1">MSKIGILDSGVGGLSVLKEVYLNNLADEVYFLGDTKYFPYGIKPVEFIQERVFEIVSFFKSLGVEEVIIACNTASSVAYDFLKDRFRDLKIHSIVLGAIEGAKNYKAKKIGVLATRRTMESNIYPRLIHEKISDKIEVYVQSCSEGPLLETIEKGIVEGELIEKEIMRCIDPLVEKNIEGLILGCTHLPFVKKVIKDLYPNLFVVDPSLEVINFLRSDSNFNTKVEIFVTGEAEEFQGILNKLLGMDWIVKKVTLDRSDVSVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0I3</accession>
    <name>B8E0I3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lipopolysaccharide biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583709.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353242.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1354"/>
    <dbReference type="EnsemblBacteria" id="ACK42628">
        <property type="protein sequence ID" value="ACK42628"/>
        <property type="gene ID" value="Dtur_1354"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1354"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_739454_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0I3"/>
    <dbReference type="OMA" id="MRDHDNA"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="9">
        <location>
            <begin position="376"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="172"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="463" mass="52417" checksum="4D824C5A28DAAE98" modified="2009-03-03" version="1">MNEERIYEDEISLAELFYIIWKRKILIITLFIVFITVALIYSLLAPKIYEAKTVILLPQQSGSTSALSALAQSLPISLGIPLSSTPSANMVAILKSRSAAEYVFKKLKLEGYFKAKNYEDALEQLMKSIKVTTNDKENTITLTAEAKDPKLAADIANTYVEALSNINASLGVYTAKRTKEFLEKQIERVKKDLEQAENRLKEFQEKNLIFDVNDEAKAVVDALAKLESEKQMTSITLKVEKENFENLKRALINQQRIQQKDLLAITSLTATSTVLSDLRNKLISQESELALLSVDYGPEHPKVISMKYAIEETKRVIRDELDRIYKAINNSSLYELFSLQMDIFVNESKLKALSDVIDEYQKRLSNLPELGLTLSKLLRDVKVQETIYTMLLSQYEQAKIDETKETAVVSVLDPAVPPSKKSKPSTVLNVLIAGVSSIFLGIFLAFFLNFWENFKREWKKLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0I7</accession>
    <name>B8E0I7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Replicative DNA helicase</fullName>
            <ecNumber evidence="3 12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Dtur_1358</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the helicase family. DnaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 12"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583712.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353246.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1358"/>
    <dbReference type="EnsemblBacteria" id="ACK42632">
        <property type="protein sequence ID" value="ACK42632"/>
        <property type="gene ID" value="Dtur_1358"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1358"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1403"/>
    <dbReference type="eggNOG" id="COG0305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005373_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0I7"/>
    <dbReference type="OMA" id="IEFHARI"/>
    <dbReference type="OrthoDB" id="1709134at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00984">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036185">
        <property type="entry name" value="DNA_heli_DnaB-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007692">
        <property type="entry name" value="DNA_helicase_DnaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007694">
        <property type="entry name" value="DNA_helicase_DnaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007693">
        <property type="entry name" value="DNA_helicase_DnaB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016136">
        <property type="entry name" value="DNA_helicase_N/primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00772">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03796">
        <property type="entry name" value="DnaB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48024">
        <property type="entry name" value="SSF48024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00665">
        <property type="entry name" value="DnaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51199">
        <property type="entry name" value="SF4_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0639">Primosome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF4 helicase" evidence="13">
        <location>
            <begin position="181"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="453" mass="51057" checksum="24DF134F10E9F2DA" modified="2009-03-03" version="1">MKNKEDILGRVPPHNEEAEQAVLGAMLLSRDAIAKVIEILNPDSFYYEHHGIIFRIIVELFEKGLPVDLVSVTEELRSRNLLERVGGSVYLASLLDVVPTAANVEYYANIVAEKALLRRLITAGTEIVSLGYRENENPELLVDKAEQLIFDIAQHHRFRTLVPLRDILAKSFKEIERIHQTGKPFTGIPTGFWDLDRKTGGFQPSDLIIVAARPGMGKTSFCLNIAQHVALEEHLPVAIFSLEMSSFQLALRLLGSEAQIDIHRLRTGQIREQEWPKLARAFGKLAEAPIFVDDTPDLNVIEMRARARRLKAEIGLSLIIVDYLQLIRLLDRDKSEHQQISEISRGLKSLARELEVPVIAISQLSRAVETRAERRPQLSDLRGSGGLEQDADVVIFIYREGYYKAQESEIDSDLPEEVEIIIAKQRNGPTGTVKLLFMKNSTSFKSLSLREEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0J6</accession>
    <name>B8E0J6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Dtur_1367</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583721.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353255.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1367"/>
    <dbReference type="EnsemblBacteria" id="ACK42641">
        <property type="protein sequence ID" value="ACK42641"/>
        <property type="gene ID" value="Dtur_1367"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1367"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1412"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028142_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0J6"/>
    <dbReference type="OMA" id="MWGFQAS"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="21"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="346" mass="37616" checksum="8C3578093AB0D1C3" modified="2009-03-03" version="1">MNGVIPRYRDLLPITDKTPLITLHEGNTPLIYANNLSKKYGIDIWLKYEGMNPTGSFKDRGMVVAIAKALEEKSEMVICASTGNTAASAAAYAALTNLKAFVVLPEKAIALGKLAQAIMYGAKIISVKGNFDDALKLVKEISQKFPITLVNSINPYRLEGQKTAAFEICDVLSRNPENLAIPVGNAGNISAYWMGFKEYYKIGKIKQLPKMLGFQAEGAAPLVKGYPIPNPQTIATAIKIGNPASWDKAINAVKESLGLIDTVSDEEILEAQKELASKEGIFVEPASAASWAGVKKLLRENRFPGKEVVCVLTGHGLKDPDIAIKQAKIDVSIEPKIEEFQKILEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0M5</accession>
    <name>B8E0M5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Tripartite ATP-independent periplasmic transporter DctQ component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584120.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353659.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1773"/>
    <dbReference type="EnsemblBacteria" id="ACK43045">
        <property type="protein sequence ID" value="ACK43045"/>
        <property type="gene ID" value="Dtur_1773"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1773"/>
    <dbReference type="eggNOG" id="COG3090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086356_4_0_0"/>
    <dbReference type="InParanoid" id="B8E0M5"/>
    <dbReference type="OMA" id="RFSLIWM"/>
    <dbReference type="OrthoDB" id="1947990at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015740">
        <property type="term" value="P:C4-dicarboxylate transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007387">
        <property type="entry name" value="TRAP_DctQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35011">
        <property type="entry name" value="PTHR35011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04290">
        <property type="entry name" value="DctQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK43045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="159" mass="18686" checksum="EF045A93B57AB037" modified="2009-03-03" version="1">MRKIYEILGKIELYMAEILLVLIVVLVFSAGVSRTLRSPIYWANPLASFFFAWATMFAMDAAYRRDKLMNVDLLVKRLPQRVQSYIKIFNYIIILAFLIYLIVFGIRLAFVQKYRTFEGMYGFSYMWATLSIPVGSFLLAITTIVKIIDEINNLRKWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Q4</accession>
    <name>B8E0Q4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-mannosidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Lysosomal beta A mannosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_1802</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584148.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353688.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1802"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK43074">
        <property type="protein sequence ID" value="ACK43074"/>
        <property type="gene ID" value="Dtur_1802"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1802"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1854"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005015_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0Q4"/>
    <dbReference type="OMA" id="KRQWKGP"/>
    <dbReference type="OrthoDB" id="245411at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041447">
        <property type="entry name" value="Mannosidase_ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17786">
        <property type="entry name" value="Mannosidase_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="11">
        <location>
            <begin position="59"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="9">
        <location>
            <begin position="199"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="10">
        <location>
            <begin position="368"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosidase_ig" evidence="12">
        <location>
            <begin position="642"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK43074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="813" mass="96290" checksum="ECE0A8852FEE2355" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0T0</accession>
    <name>B8E0T0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1393</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583745.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353281.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1393"/>
    <dbReference type="EnsemblBacteria" id="ACK42667">
        <property type="protein sequence ID" value="ACK42667"/>
        <property type="gene ID" value="Dtur_1393"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1393"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1440"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_0"/>
    <dbReference type="InParanoid" id="B8E0T0"/>
    <dbReference type="OMA" id="NCRGYLE"/>
    <dbReference type="OrthoDB" id="1529383at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="34"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="210" mass="24122" checksum="A2FB949E156F818E" modified="2009-03-03" version="1">MERLNKVGKLEILRREAEGCRNCSLWQERTNLVFGEGNPDAFIMFVGEAPGFHEDQQGKPFVGAAGKLLTELIESIGLKREDVYIANVLKCRPPNNREPLPEEIRVCFPFLRQQIEIINPKIICTLGRYAAYAILGHSVNISTSHGKDYYVDGRRVFVTYHPAAALYHGKLLENIKKDFEKLKELYEAVLKSEKEQNLPNKKEKEQLSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0T5</accession>
    <name>B8E0T5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cell division topological specificity factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">minE</name>
        <name evidence="4" type="ordered locus">Dtur_1398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the MinE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583750.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353286.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1398"/>
    <dbReference type="EnsemblBacteria" id="ACK42672">
        <property type="protein sequence ID" value="ACK42672"/>
        <property type="gene ID" value="Dtur_1398"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1398"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1445"/>
    <dbReference type="eggNOG" id="COG0851">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137929_1_2_0"/>
    <dbReference type="InParanoid" id="B8E0T5"/>
    <dbReference type="OMA" id="VHDRANV"/>
    <dbReference type="OrthoDB" id="2038628at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000918">
        <property type="term" value="P:division septum site selection"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1070.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00262">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005527">
        <property type="entry name" value="MinE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036707">
        <property type="entry name" value="MinE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03776">
        <property type="entry name" value="MinE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55229">
        <property type="entry name" value="SSF55229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01215">
        <property type="entry name" value="minE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="80" mass="9287" checksum="AF9FA2C9FE612674" modified="2009-03-03" version="1">MLLNTIWGRKITSKDVAKERLQVVLVYDRAKIEPQLVEKLKEDLVNTVSKYLTFDSNNIKIELSSEDNKSILRIDIPLKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0V3</accession>
    <name>B8E0V3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purD</name>
        <name evidence="10" type="ordered locus">Dtur_1416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583768.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353304.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1416"/>
    <dbReference type="EnsemblBacteria" id="ACK42690">
        <property type="protein sequence ID" value="ACK42690"/>
        <property type="gene ID" value="Dtur_1416"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1416"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1463"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_0"/>
    <dbReference type="InParanoid" id="B8E0V3"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="413" mass="46037" checksum="8E1833817282E690" modified="2009-03-03" version="1">MKVLVVGSGGREHAICWKLSQDSNVDKIYAIPGNAGISSIANCLPFKVEDIDSIVKFAKENRIDWTIVGPELPLAIGISDKFKENGLEIWGPVKNLAKLEASKAFAKEIMRKAGIPTANFRIFDNFGDIKEFLKKERYPLVIKADGLAAGKGVFIVNNVEEGLEIANKLFNEEILGEAGKKVVVEEFLNGREFSLIAAIKGEEIYYLPPAQDYKRIGEGNTGPNTGGMGSYAPVPWIDERLIKVCDEKIFKPLMDEIHKMGLQYEGFLYGGLILVDGEPYVLEFNVRLGDPEAQVILPLLDFSFLSFKEGTWKDKKIKDKKAVCVVLASKGYPGNYEVGREIKIRESEEVIIFHAGTKWVDGKLVTAGGRVLNVVALGESFKEARDKVYKNINNISFENMYYRKDIALEVENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0V6</accession>
    <name>B8E0V6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="11" type="ordered locus">Dtur_1419</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583771.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353307.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1419"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="ACK42693">
        <property type="protein sequence ID" value="ACK42693"/>
        <property type="gene ID" value="Dtur_1419"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1419"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1466"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_0"/>
    <dbReference type="InParanoid" id="B8E0V6"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="OrthoDB" id="267682at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="7"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="7"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="461" mass="52153" checksum="BFA25339C24A9B3A" modified="2009-03-03" version="1">MKIREECGVVGVVTKEKGQASFIAYRVLLKLQHRGQESVGIVTFSGNDHYLHKNFGLVSQVFNEEILKRLKGRIAIGHVRYSTSGKSKEENIQPFLVNLPRYGYVALAHNGHIANSDSLRRVLEKDGVIFQSSSDTEVILHLIAKSQKTTLKERLKEALSKLEGSYSLVIGSEEGIYGIRDPYGFRPLFLGRLYDGTFIFASETCALKEYHLVDLLEIEPGEIIYINKNGEINRERFLESSISRFCLFEFIYFSRPDSIYDGKTVYYYRKEMGKVLAKESPVDADWVVPVPDSGIPAAIGYSEESGIPLQMLLMRSHYVGRTFIQPKQKERESGVRMKFLFIGDLIKGKRIVLVDDSLVRGTTGRILAEKLREEGAKEVHLRLSSPPLIHPCHYGVDIPNTKELISYYYSPEEISKILGFDSVAFLSMEGLLSILPERGYCGECFGKKMVKKEKGKLLLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0X0</accession>
    <name>B8E0X0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583785.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353321.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1433"/>
    <dbReference type="EnsemblBacteria" id="ACK42707">
        <property type="protein sequence ID" value="ACK42707"/>
        <property type="gene ID" value="Dtur_1433"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1433"/>
    <dbReference type="HOGENOM" id="CLU_1394405_0_0_0"/>
    <dbReference type="OMA" id="YISNIWT"/>
    <dbReference type="OrthoDB" id="2112716at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="195" mass="23312" checksum="866993CBDBB3EDCD" modified="2009-03-03" version="1">MGLVYQPWFIPITIIFFIILRSYLEKKEELHYQEDAKKYIKVEGSEEVVPPWRKQGEKKAEKPKRGFGFWLLNIILILYVLFVWVLTRYHGFSKEVYEIIAGFTIALYFFYLDIPGYISNIWTYREYPGSVKGEITLSKHFIYSSKKNEAKIFLIISFFYYLMTLSNIILGAIFALIIRVWFIDRRLSKISLPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8E112</accession>
    <name>B8E112_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="7">MECDP-synthase</shortName>
            <shortName evidence="7">MECPP-synthase</shortName>
            <shortName evidence="7">MECPS</shortName>
            <ecNumber evidence="3 7 8">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ispF</name>
        <name evidence="10" type="ordered locus">Dtur_1475</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the IspF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="3 7 8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583827.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353363.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1475"/>
    <dbReference type="EnsemblBacteria" id="ACK42749">
        <property type="protein sequence ID" value="ACK42749"/>
        <property type="gene ID" value="Dtur_1475"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1475"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1524"/>
    <dbReference type="eggNOG" id="COG0245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084630_2_0_0"/>
    <dbReference type="InParanoid" id="B8E112"/>
    <dbReference type="OMA" id="QHFGTGR"/>
    <dbReference type="OrthoDB" id="1716560at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YgbB" evidence="9">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="64"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="4-CDP-2-C-methyl-D-erythritol 2-phosphate binding" evidence="7">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="164" mass="18069" checksum="33EDF2CE24A42F91" modified="2009-03-03" version="1">MDRRDYTKIRVGLGYDVHPFEEGRELFLGGIKIPFDKGLKGHSDGDVLIHAIADALLGASALPDIGYFFPVDDKSIEGIPSTIILEKVRDLLKEKGVNIINIDCTIIAEEPKIMPFRDKIIKNLSSILRIPEDCLSVKATTNEKLGFIGKKEGIAVFAVALVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E126</accession>
    <name>B8E126_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583841.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353377.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1489"/>
    <dbReference type="EnsemblBacteria" id="ACK42763">
        <property type="protein sequence ID" value="ACK42763"/>
        <property type="gene ID" value="Dtur_1489"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1489"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1538"/>
    <dbReference type="eggNOG" id="COG4708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104115_0_0_0"/>
    <dbReference type="InParanoid" id="B8E126"/>
    <dbReference type="OMA" id="MITVAIE"/>
    <dbReference type="OrthoDB" id="1453082at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010387">
        <property type="entry name" value="QueT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40044">
        <property type="entry name" value="PTHR40044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06177">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031501">
        <property type="entry name" value="QueT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="157" mass="17606" checksum="F92591EC88907F52" modified="2009-03-03" version="1">MRSKKVAKIALYAASYSVLTVILSPISYGPIQVRISEFMTLFPFIDKLAIPGLFIGCAIANLFSPAGWIDVIFGSLFTLIAAYLTRKMPNVYLSPIPPILINAFGVSLYLHLFFKLPYLLNVLYIGVGETIATYIIGLPILLYIFRNENLKKFFTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E130</accession>
    <name>B8E130_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ispE</name>
        <name evidence="11" type="ordered locus">Dtur_1493</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583845.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353381.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1493"/>
    <dbReference type="EnsemblBacteria" id="ACK42767">
        <property type="protein sequence ID" value="ACK42767"/>
        <property type="gene ID" value="Dtur_1493"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1493"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1542"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_2_0_0"/>
    <dbReference type="InParanoid" id="B8E130"/>
    <dbReference type="OMA" id="ADTNFFI"/>
    <dbReference type="OrthoDB" id="1938933at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="86"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="291" mass="33282" checksum="2CFDA5A4745EF7B6" modified="2009-03-03" version="1">MEKLNIYTFGKITLFLDVINKREDGYHNVKILLHNVDFWDFMQISLLPYPHFILESNLPIPSEENLVYKAYKKFIEITGEKVGAKVFLFKKIPTQAGLGGGSSNAAGTIWGLNLLTNLNLPLRDMAKIGETLGSDIPFFFYGGSAIAEGKGEIIKKITHQNFKFILIFPPYGISTKEIYSKIKKEDLNIHIDFENILLNFERGILLEPYNFFEYIVFKRYPELKKIKESISPITYVALTGTGSTMFVVIKNDSEIKEIIKKLEEYLEKGYKIKLVKSSPFGIKILKIKGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8E135</accession>
    <name>B8E135_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583850.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353386.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1498"/>
    <dbReference type="EnsemblBacteria" id="ACK42772">
        <property type="protein sequence ID" value="ACK42772"/>
        <property type="gene ID" value="Dtur_1498"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1498"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1547"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_2_2_0"/>
    <dbReference type="InParanoid" id="B8E135"/>
    <dbReference type="OMA" id="WEILCGF"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="6">
        <location>
            <begin position="234"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="378" mass="43012" checksum="F3AFA0E9B31D5044" modified="2009-03-03" version="1">MKEILAWREINLSFLLDNLKVIKEKVGGKVDVIAVVKADAYGHGAKVISLFLQKYANINTFAVAHIDEGIFLRKIGVNKKILVLSPQLKSSIPYYFEYELTPVISDIEFLDELGKYSNNKDKKLKVHLIFDTGMGREGFLPSESEEILKLLRRYPNLILEGISSHLSNPENKKDPYNIFQKKLFYDIYNQFKDEDLVFHFSNTGGIFNFPEFHFNAVRPGISLYGYGDKLLKPVMEIKARITLVKELPEGWGVGYGHTFMTEKSTKIAIVPLGYADGYRRDLSNKGRVIVNGEYCKIIGRVSMDQFTIDITDKEVKRGDLVTVMGRENEKMVDAQELAILSNTIPYEILTGFGSAKRLKSIYKFQGKVLNDPITELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E136</accession>
    <name>B8E136_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">V-type ATPase, D subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1499</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583851.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353387.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1499"/>
    <dbReference type="EnsemblBacteria" id="ACK42773">
        <property type="protein sequence ID" value="ACK42773"/>
        <property type="gene ID" value="Dtur_1499"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1499"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1548"/>
    <dbReference type="eggNOG" id="COG1394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069688_2_1_0"/>
    <dbReference type="InParanoid" id="B8E136"/>
    <dbReference type="OMA" id="TQKRANA"/>
    <dbReference type="OrthoDB" id="1334900at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033176">
        <property type="term" value="C:proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="PTHR11671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="141"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="201" mass="23827" checksum="001A3C0CB1492736" modified="2009-03-03" version="1">MPLKVNPNRMELLRLRKRLAIAKRGHKLLQDKLEGLIQRFMEEVQNYRTLRELIEKEFLEFLSVGGMVYIRLSGPLWETLLQVNDGKTTVFSKLAKKMNIPVKEISVGNLYIPFYSYLETPSMMDELVERWSKLLENIIALANKERYLISLAEEIERTKRRVNALEYKLIPQIEETIKLITVKLEELERSNFFRLLRLKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E138</accession>
    <name>B8E138_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="7">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpA</name>
        <name evidence="11" type="ordered locus">Dtur_1501</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583853.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353389.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1501"/>
    <dbReference type="EnsemblBacteria" id="ACK42775">
        <property type="protein sequence ID" value="ACK42775"/>
        <property type="gene ID" value="Dtur_1501"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1501"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1550"/>
    <dbReference type="eggNOG" id="COG1155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_0"/>
    <dbReference type="OMA" id="TAFVQVY"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="9">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_Xtn" evidence="10">
        <location>
            <begin position="83"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="8">
        <location>
            <begin position="211"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="231"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="589" mass="66122" checksum="1BC6D88BCB1E3494" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E146</accession>
    <name>B8E146_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding LysM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583258.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352788.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0893"/>
    <dbReference type="CAZy" id="CBM50">
        <property type="family name" value="Carbohydrate-Binding Module Family 50"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42174">
        <property type="protein sequence ID" value="ACK42174"/>
        <property type="gene ID" value="Dtur_0893"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0893"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1862005_0_0_0"/>
    <dbReference type="OMA" id="KYGVDWR"/>
    <dbReference type="OrthoDB" id="2063919at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="86"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="137" mass="15978" checksum="F117D0B16D180E56" modified="2009-03-03" version="1">MKRFLREVLIYSISFLLIAFLTSQLFSLEKRPYFENSEFVRDNKLNIENKTLTQTLVYTETFKADVNQNNVSKTVTVQEIKQPDKIIYEVKVGDTMIGIAQKYGVDWREIAKVNKLKDPNYLVVGQKLIIPLKSKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E150</accession>
    <name>B8E150_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583262.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352792.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0897"/>
    <dbReference type="EnsemblBacteria" id="ACK42178">
        <property type="protein sequence ID" value="ACK42178"/>
        <property type="gene ID" value="Dtur_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0897"/>
    <dbReference type="HOGENOM" id="CLU_1683768_0_0_0"/>
    <dbReference type="OMA" id="LMEFYFV"/>
    <dbReference type="OrthoDB" id="2135157at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="156" mass="18626" checksum="A7ED6548F92885B4" modified="2009-03-03" version="1">MKNFDLLYFVNIILHFVSICYILGTSGFFTLLLLKIKDKDSLLKTLKSFTDYLPFFMLLYLVTTLAYIFVDKKIIWAIKYDHNANLLIKFYVPFFIASILLAHHLRNKIIKLSKLEITLIPNCEWWKIKIDISVLMEFYFVILIIESLMVYLIYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E153</accession>
    <name>B8E153_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583265.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352795.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0900"/>
    <dbReference type="EnsemblBacteria" id="ACK42181">
        <property type="protein sequence ID" value="ACK42181"/>
        <property type="gene ID" value="Dtur_0900"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0900"/>
    <dbReference type="eggNOG" id="COG1839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138382_0_0_0"/>
    <dbReference type="InParanoid" id="B8E153"/>
    <dbReference type="OMA" id="FGIAFCE"/>
    <dbReference type="OrthoDB" id="1392364at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="PTHR36155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="SSF103165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="160" mass="17696" checksum="FA1E2D7AB8D38D4A" modified="2009-03-03" version="1">MEIQIVEIEKPAEVNVILGQTHFIKSVEDLYEAIMNTVPGAKFGIAFCEASGPALIRHVGTDEEMEDLAIKNLQKIAAGHSFIIFIRNFYPINVLNAIKHVPEVVNIFAATANPLKVVVIDDGVGRGIIGVIDGVKPKGVEGEEDMRHRKEFLRKIGYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E155</accession>
    <name>B8E155_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583267.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352797.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0902"/>
    <dbReference type="EnsemblBacteria" id="ACK42183">
        <property type="protein sequence ID" value="ACK42183"/>
        <property type="gene ID" value="Dtur_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0902"/>
    <dbReference type="HOGENOM" id="CLU_719109_0_0_0"/>
    <dbReference type="OMA" id="YIPGFIC"/>
    <dbReference type="OrthoDB" id="2113441at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="384" mass="44958" checksum="505F747606E0C006" modified="2009-03-03" version="1">MYTIDENSLSVKDFTLILNSDSEIEISEDLKNKIFLCSNLLKTHFEVLDKNMNTKNYKEFEGNGLLNEREVRGIILATIYTLANGRSGVSYETIEKLIDLFQNRETIKIPEFSLSTKLDTLTPNHYLLNYVKDIAPIERKLLIKSLAYIPGFICSYFEDLQLVKKLLTISLVLYFNYPYMDSYNLASSPHLPFIKLAENINLFFIAENKNKNRSIDPLIFSYVSYLYKLLDDLQELLNIQLNSSHHPFIFIPENNTFIKNSLLIPQKLYLLKTVENLILTVDKTFESFLTKIGSFEDKITIYNVFYSLKQCSNEILLTLKYKIKIYKKILAFILYEYAVKDKAQSLDQVLKSFMKEKNIKNYKELEPLLKDLLKTIEEKINELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8E176</accession>
    <name>B8E176_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrE</name>
        <name evidence="6" type="ordered locus">Dtur_0923</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583288.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352818.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0923"/>
    <dbReference type="EnsemblBacteria" id="ACK42204">
        <property type="protein sequence ID" value="ACK42204"/>
        <property type="gene ID" value="Dtur_0923"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0923"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.960"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_3_0_0"/>
    <dbReference type="InParanoid" id="B8E176"/>
    <dbReference type="OMA" id="YFQCAKV"/>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006222">
        <property type="term" value="P:UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006273">
        <property type="entry name" value="Orotate_PRibTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01367">
        <property type="entry name" value="pyrE_Therm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="43"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="112"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="189" mass="20846" checksum="86EEBC3581DE4941" modified="2009-03-03" version="1">MNWLEIFKEKGAFLEGHFLLSSGLHSPNYLQCALILQYPDLSEKIAKEIAEKIPKDLQIDVVVGPALGGIIVAYELARALKVRGIFAEREEGKMKLRRGFNINPGEKVLICEDVVTTGGSALEVAELVKEYGGEVVAFACIVDRSGGKKIFDEPLYSLIQLKLDTYKPEECPLCKEGVPLVKPGSRNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E178</accession>
    <name>B8E178_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583290.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352820.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0925"/>
    <dbReference type="EnsemblBacteria" id="ACK42206">
        <property type="protein sequence ID" value="ACK42206"/>
        <property type="gene ID" value="Dtur_0925"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0925"/>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_3_1_0"/>
    <dbReference type="InParanoid" id="B8E178"/>
    <dbReference type="OMA" id="GHPTHKT"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="215" mass="24543" checksum="6B2E398B25733299" modified="2009-03-03" version="1">MKIFWDKPIDVSLLIHEDMLFWPNDPKFQREWVAKISEGKNANLSKITLGSHTGTHIDTPYHFLDHGKTLENIDISRFYGFAKVFEIKNPNKILLQDIETLPIEEGDIILFKTKNSLLLKENIFHDDYVGLSLEAARYLADKNVKTIGIDYLSIGPRGDEGREVHRILLGKEIGIIEGLNLLEIKEGRYFMMALPLKIKGGEGSPVRAILFPIEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E183</accession>
    <name>MTAD_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-methylthioadenosine/S-adenosylhomocysteine deaminase</fullName>
            <shortName evidence="1">MTA/SAH deaminase</shortName>
            <ecNumber evidence="1">3.5.4.28</ecNumber>
            <ecNumber evidence="1">3.5.4.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtaD</name>
        <name type="ordered locus">Dtur_0930</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-adenosyl-L-homocysteine = NH4(+) + S-inosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:20716"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:57985"/>
            <dbReference type="EC" id="3.5.4.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + H2O + S-methyl-5'-thioadenosine = NH4(+) + S-methyl-5'-thioinosine</text>
            <dbReference type="Rhea" id="RHEA:25025"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:48595"/>
            <dbReference type="EC" id="3.5.4.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.28" evidence="1"/>
    <dbReference type="EC" id="3.5.4.31" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583295.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352825.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E183"/>
    <dbReference type="SMR" id="B8E183"/>
    <dbReference type="STRING" id="515635.Dtur_0930"/>
    <dbReference type="EnsemblBacteria" id="ACK42211">
        <property type="protein sequence ID" value="ACK42211"/>
        <property type="gene ID" value="Dtur_0930"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0930"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.967"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_1_0"/>
    <dbReference type="InParanoid" id="B8E183"/>
    <dbReference type="OMA" id="ALIGKVC"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090614">
        <property type="term" value="F:5'-methylthioadenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050270">
        <property type="term" value="F:S-adenosylhomocysteine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01281">
        <property type="entry name" value="MTA_SAH_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023512">
        <property type="entry name" value="Deaminase_MtaD/DadD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000140351" description="5-methylthioadenosine/S-adenosylhomocysteine deaminase">
        <location>
            <begin position="1"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01281"/>
        </source>
    </evidence>
    <sequence length="426" mass="47673" checksum="CBC6D531364E6EB3" modified="2009-03-03" version="1">MRILIENVSVFQEGDILNNKNILIENDIIKEISEDKNFEKIDYVIEGKNKIALPGLVNTHTHLAMTLFRGFADDLPLKEWLEEKIWPQEAKLTAEDVYWGSLLGICEMIKGGTIAFADMYFFMDEVAKAVSESGVKASLSVGMIGVSGNENEILNRGVNFAQNWHNAENGRIKVMLAPHAPYTCPPSFLEKVINKAVEMNLSIHTHLSETYLEVENIKNIYGLTPVRLMDRIGLFNVPVLAAHCVFVDDEEIEILSEKGVGVAHNPQSNLKLASGVAPVKKMVEKRVKIGLGTDGPASNNNLDLWEEIRLVATLHKGVEKDPVCIPAKEALNMATKNGMEILGFENSGIIKEGYKADLILVNINKPHFYPRHNLISHLVYSALSSDVDTVIVDGKVLMEKRELKILDEEKIMFEAEKRAFDLIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E186</accession>
    <name>B8E186_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0933</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583298.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352828.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0933"/>
    <dbReference type="EnsemblBacteria" id="ACK42214">
        <property type="protein sequence ID" value="ACK42214"/>
        <property type="gene ID" value="Dtur_0933"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0933"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.970"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_3_0_0"/>
    <dbReference type="InParanoid" id="B8E186"/>
    <dbReference type="OMA" id="YIVGCFM"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015188">
        <property type="term" value="F:L-isoleucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015190">
        <property type="term" value="F:L-leucine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015192">
        <property type="term" value="F:L-phenylalanine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005304">
        <property type="term" value="F:L-valine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042941">
        <property type="term" value="P:D-alanine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015808">
        <property type="term" value="P:L-alanine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903806">
        <property type="term" value="P:L-isoleucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903785">
        <property type="term" value="P:L-valine transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098713">
        <property type="term" value="P:leucine import across plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015823">
        <property type="term" value="P:phenylalanine transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="293" mass="31600" checksum="079B9D823CDC7FC2" modified="2009-03-03" version="1">MLENILQQIINGISLGSIYALIALGYTMVYGILRLINFAHGDIYMLGAFIGFFALGSWNMPFAFGLIVAMLLTAVIGILVEKLAYKPLRNAPRISLLITAIGVSFFLENIMVLLVGATPRAFPQKIPTEIYFIGELIITNKQIIILSVSILLMLFLQFIVNKTKIGRAMRAVSQDKEMAQMLGVNIDNVISFTFALGSALAAAGGVLVGMYFNKIEPYMGVMPGLKAFVAAVLGGIGIIPGAMLGGFIMGIAEVLVSGFISSTIRDAVAFVILIIILLIKPTGILGKYMREKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E192</accession>
    <name>B8E192_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583304.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352834.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0939"/>
    <dbReference type="EnsemblBacteria" id="ACK42220">
        <property type="protein sequence ID" value="ACK42220"/>
        <property type="gene ID" value="Dtur_0939"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0939"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.976"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100236_1_1_0"/>
    <dbReference type="InParanoid" id="B8E192"/>
    <dbReference type="OMA" id="RLDHRNP"/>
    <dbReference type="OrthoDB" id="1665714at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="179" mass="20814" checksum="A444F04A226E0180" modified="2009-03-03" version="1">MEIYLADLHSEVGKVFHFEEDFIPHCEDISFIEPVHVKLKLVNLGKEVLIKGSLKTKIKLVCSRCLREFPYELEAKIQEIYLWDIPIQRNISPGEIIELKDEDFKFVLEKESLFLDPLVEDIIRLNIPVKPLCRPDCKGLCPGCGQDLNLGECECSKKIQVDPRWEPLMKFMDKKEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E195</accession>
    <name>B8E195_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="3">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0942</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583307.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352837.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0942"/>
    <dbReference type="EnsemblBacteria" id="ACK42223">
        <property type="protein sequence ID" value="ACK42223"/>
        <property type="gene ID" value="Dtur_0942"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0942"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.979"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_0_1_0"/>
    <dbReference type="InParanoid" id="B8E195"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="5">
        <location>
            <begin position="5"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="305" mass="34550" checksum="A9E536E6784B9A2B" modified="2009-03-03" version="1">MSVFVFPGQGSQYVGMFSEFLDKEEFKDYFERVKEVVGEDFIKKVQEGPEDVLRDTRISQPGIFIVSVILSDYLMENGVIPKYLVGHSLGEYSAFYAGKVFNFETGLKLIKKRAEVMNSVAERVDGGMWAVIGDLSEIEESLMELQKEEIPLWAANYNAPSQLVLSGKKEAFEIWYSKMKNKVKKVVPLSVSGPFHSPLMREAEEIFKSYLENIEFSDPKTYIVSSTTGDVVKSKEEAKEILVKQFTSSVRWIDAINKLTDLGERIFIEVGPGKVLQGLIKKIDFNVKVLGVEKVEDLEKIRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E199</accession>
    <name>B8E199_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease 3</fullName>
            <ecNumber evidence="6">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribonuclease III</fullName>
            <shortName evidence="6">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnc</name>
        <name evidence="10" type="ordered locus">Dtur_0946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583311.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352841.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    <dbReference type="STRING" id="515635.Dtur_0946"/>
    <dbReference type="EnsemblBacteria" id="ACK42227">
        <property type="protein sequence ID" value="ACK42227"/>
        <property type="gene ID" value="Dtur_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0946"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.983"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="OrthoDB" id="1890943at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ribonuclease III activity"/>
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    </dbReference>
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        <property type="term" value="F:rRNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:mRNA processing"/>
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    </dbReference>
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        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="P:RNA processing"/>
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        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="15"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="167"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="238" mass="27930" checksum="80E14E6321B3B9EE" modified="2009-03-03" version="1">MRDRNIRNVKVEDIVERVKEKTRVSFNDKDLLIEALTHPSFKHENPNFKQDNQRLEFLGDAVLNMIITEILFQRYREASEGFLTQKRIYLVKEETLYKKAKSLDLGELILLGVGEEKQGGRDKISILSDLFEAFIGALYLDKGYEYTKNFVEEIFKEEIESIEMEVDWKNLLQTYLQKEGKKPQYIVSREVGPEHDKTFYVELWIDDEKISEGEGKNKREAEIKAAQKALEKIKNDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1B6</accession>
    <name>B8E1B6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase M22 glycoprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352858.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0964"/>
    <dbReference type="EnsemblBacteria" id="ACK42244">
        <property type="protein sequence ID" value="ACK42244"/>
        <property type="gene ID" value="Dtur_0964"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0964"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1001"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1B6"/>
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    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="232" mass="26697" checksum="16B7013FAB6C2F51" modified="2009-03-03" version="1">MFILGINTAFEKSNIILWKDNKLYELFYSTDSKTYGETLTINIKTLLDLSGWKLEDIDLYTIITGPGSFTGLRIGIVTVKTLAQIFKKPIIGISYLECLAYQTPFLGMKVPIMPARRGEIHAGFYNAKNERIYNEGIFSYQDFINLLSTLKKEPVIIIGKIPDDLKFLIPEDIIISSEHQNSPRGEAIIYLSLEKYKKGDTLDYLNLLPDYRQKSSAEINWERRNARPEREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1D2</accession>
    <name>B8E1D2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ordered locus">Dtur_0980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583344.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352874.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0980"/>
    <dbReference type="EnsemblBacteria" id="ACK42260">
        <property type="protein sequence ID" value="ACK42260"/>
        <property type="gene ID" value="Dtur_0980"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0980"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1017"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_0"/>
    <dbReference type="InParanoid" id="B8E1D2"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="11"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="106" mass="12068" checksum="AAECE599BAD5A48F" modified="2009-03-03" version="1">MSSYLEKQKIRIKLKAFDHRVLDLSTKKIIDTVRGTGAKISGPIPLPTKVTRYWVLRSPHVNKNSGEHFEIRIHKRLIDIIEPTAKTVEALMNLELPAGVEVEIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1F1</accession>
    <name>B8E1F1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ordered locus">Dtur_0999</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583363.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352893.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0999"/>
    <dbReference type="EnsemblBacteria" id="ACK42279">
        <property type="protein sequence ID" value="ACK42279"/>
        <property type="gene ID" value="Dtur_0999"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0999"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1036"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_1_0"/>
    <dbReference type="InParanoid" id="B8E1F1"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="33"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="148" mass="16204" checksum="064A30B1548DACAC" modified="2009-03-03" version="1">MKLFELKPKLGSRKKPKRVGCGYAASGKYAGRGMSGQNARTGDGVRPGFEGGQTPLTRRLPKMEGIPRAPRRKYTVVNLSTLEKKFEANEVVDPNILLERKIIKEIGFGVKILGDGELTKPLVVKAHAFSEKAREKIESVGGKAEVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1J6</accession>
    <name>B8E1J6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582606.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352135.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0192"/>
    <dbReference type="EnsemblBacteria" id="ACK41521">
        <property type="protein sequence ID" value="ACK41521"/>
        <property type="gene ID" value="Dtur_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0192"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1J6"/>
    <dbReference type="OMA" id="WIKEEEF"/>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="176" mass="19847" checksum="AA781DDC6A81E8BA" modified="2009-03-03" version="1">MSLWDLFLVFLKIGWLTLGGGYVMVPLFLEEIVKKRSWMNEDTFLQTLTLAQLFPGPIAFNLAVAVGYKLKKIKGAIMCGLAVVLPSFVSILVIAIFFLSFEKLKIVQGFFYGIRPAIASAMVVAVLELIKKRKWSKLNILSFTVLSILLIFFKINPIYIILISLGVVILWVYMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1R5</accession>
    <name>B8E1R5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582783.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352312.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0394"/>
    <dbReference type="EnsemblBacteria" id="ACK41698">
        <property type="protein sequence ID" value="ACK41698"/>
        <property type="gene ID" value="Dtur_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0394"/>
    <dbReference type="HOGENOM" id="CLU_2329257_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="98" mass="11385" checksum="8EF4A2DF0CEB8DA8" modified="2009-03-03" version="1">MRYFNVLGIFIFLLLMLVLHTGEVYSWGGTIHSEIVRDAYYYMERSSYATSQQKNSAVWRTNNWGFPSDRPWDIMARGAVEFDELTKLSLATFGYLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1S0</accession>
    <name>B8E1S0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ordered locus">Dtur_0399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582788.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352317.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0399"/>
    <dbReference type="EnsemblBacteria" id="ACK41703">
        <property type="protein sequence ID" value="ACK41703"/>
        <property type="gene ID" value="Dtur_0399"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0399"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092688_2_2_0"/>
    <dbReference type="InParanoid" id="B8E1S0"/>
    <dbReference type="OMA" id="VVHVFQK"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="116" mass="13426" checksum="18A03653FC54B783" modified="2009-03-03" version="1">MNFLESKEKALRIARIVLEKKAENVIIIDVSQIPGLTDYLVICTGLTNTQRKAIQRSVEEEMEKLGFTPRGIEGREGTGWTLLDYYDLIVHIFSPRAREFYDLESLYENVPKITEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1S9</accession>
    <name>B8E1S9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, DeoR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0408</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582797.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352326.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0408"/>
    <dbReference type="EnsemblBacteria" id="ACK41712">
        <property type="protein sequence ID" value="ACK41712"/>
        <property type="gene ID" value="Dtur_0408"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0408"/>
    <dbReference type="eggNOG" id="COG1349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060699_1_4_0"/>
    <dbReference type="InParanoid" id="B8E1S9"/>
    <dbReference type="OMA" id="STHEPGF"/>
    <dbReference type="OrthoDB" id="1629121at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014036">
        <property type="entry name" value="DeoR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001034">
        <property type="entry name" value="DeoR_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018356">
        <property type="entry name" value="Tscrpt_reg_HTH_DeoR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00455">
        <property type="entry name" value="DeoRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08220">
        <property type="entry name" value="HTH_DeoR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00037">
        <property type="entry name" value="HTHLACR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00420">
        <property type="entry name" value="HTH_DEOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00894">
        <property type="entry name" value="HTH_DEOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51000">
        <property type="entry name" value="HTH_DEOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="HTH deoR-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="257" mass="28563" checksum="50B37AEE450E8342" modified="2009-03-03" version="1">MLPEERRTKILELLEKERGIKVSDLVRIFNVTGATIRRDLEILEKEGLLKRTHGGAVLPHSFSFEPLYITKKRQNLKEKQAIGKIAAELINDGESVFIETGSTTLQIAKNIKHKHDVTVVTNSIEVARELLSARGVEVILTGGLLRKETVALVGPIAERVLREFRVDKVFLGISGIIPSKGMYTASIAEAQIKKLIIEMGREIIGVSDHSKFGKECFAFVAPTNAMSKIIVDEKVSPQYIEELKKRGVEVIIAPVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1U9</accession>
    <name>B8E1U9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pectate lyase</fullName>
            <ecNumber evidence="4">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582817.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352346.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0430"/>
    <dbReference type="CAZy" id="PL1">
        <property type="family name" value="Polysaccharide Lyase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41732">
        <property type="protein sequence ID" value="ACK41732"/>
        <property type="gene ID" value="Dtur_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0430"/>
    <dbReference type="eggNOG" id="COG3866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1U9"/>
    <dbReference type="OMA" id="NYWIDHV"/>
    <dbReference type="OrthoDB" id="660314at2"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018082">
        <property type="entry name" value="AmbAllergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PTHR31683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00807">
        <property type="entry name" value="AMBALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Amb_all" evidence="9">
        <location>
            <begin position="47"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="335" mass="37259" checksum="82E39CB113D2CD73" modified="2009-03-03" version="1">MRKYIIVLMILLGVILVLGFSQEELKENVLTLNDKPVGFGEATTGGAGGKIVTVDNVNDFKNYAQVQEPYIILVKGVIDTSKETGQVNIASNKTIIGVTPDASIIGWGVYLKGVNNVIIRNLTIKNKVENPKNDAITVEASQNVWIDHCTLSSDMVVAPEREKDKDKVDALLDIIKGSKGITVSWNIFENSWKCTQVGSSDNSTIDAEARVTYHHNIFRNTNSRNPSVRFGTVHIFNNYYQNILLYAIASRMGAKLLVENNYFETVALPITTQFESPQDGYVKESGNLYWECGDNNITQELKELRVPYQYELDEADVVPYLLDKGAGAGKEVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1W1</accession>
    <name>B8E1W1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PfkB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352358.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0442"/>
    <dbReference type="EnsemblBacteria" id="ACK41744">
        <property type="protein sequence ID" value="ACK41744"/>
        <property type="gene ID" value="Dtur_0442"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0442"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1W1"/>
    <dbReference type="OMA" id="CIGIEPL"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="326" mass="37290" checksum="93AC5ABEDC26DB47" modified="2009-03-03" version="1">MMIEGGNMIDVISYGEVMLRFTPERYRTFLSSNTWNVEVGGTEANVLVALSLLGLKTEFISFFPDNFLGFKAISELKKYGVGVEKVRLIPEGRMGLYFVELHHRSKGIRVLYDRRDSSFSIGVLSDTDLEFIRKAKLIHLTGVTPSLSEVCKSNVIKICTSKKDSQILSFDINYRKKLWGEKECRRFLDIILPFVDILFVKKEDYNLLFEEENNEEKILYKLQKTYGKDKIYVLTQGEEGCSVLYKDEYFSQQAYNTDVVDRIGAGDAFVAGFLYGYLKGKDLKNSAKYGSLLASIKMSIFGDFPALDRKTLLDLLESENNRSVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E201</accession>
    <name>B8E201_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lar_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582869.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352398.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0486"/>
    <dbReference type="EnsemblBacteria" id="ACK41784">
        <property type="protein sequence ID" value="ACK41784"/>
        <property type="gene ID" value="Dtur_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0486"/>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050189_0_0_0"/>
    <dbReference type="InParanoid" id="B8E201"/>
    <dbReference type="OMA" id="GSVEPHY"/>
    <dbReference type="OrthoDB" id="313921at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="417" mass="47692" checksum="9FBCF022631921B9" modified="2009-03-03" version="1">MFSYYLPYGKNKIEIIIPYKADILEPKRVKTNKSKDLLIYEALDNPLGLNSLSVFLKSKNNIAISIEDDTRPINNKEILRILFNYLREKEIKGKNIKIIVATGLHQDKTLYDFSDISYDFSVEVIKHDPDKGLIFLEDENLERVGINKEFIEADARIIIGDVVPHQIFGFSGPPKSIIPGLADRETINKTHKQVLFHELKAGIEDNIVLKWVVNFSKKIPNIFSINLIQDVEKNIINVIAGEITESFKKAIEKSKELYCIEVSKEYDVVITSPGGYPEDQDLYQTQKAFRHASYITKEGGKIIVFAPCSRGWGSEDFKRITEELYDVDKTIEELKFNFSVGKHKLLFFLELAKKYKLYLYSDYDFSKNISRFVTGVTSTDLAEILNQEDKNIAILYGGNFLVPVLKKSKGGEISYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E205</accession>
    <name>B8E205_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582873.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352402.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0490"/>
    <dbReference type="CAZy" id="GH31">
        <property type="family name" value="Glycoside Hydrolase Family 31"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41788">
        <property type="protein sequence ID" value="ACK41788"/>
        <property type="gene ID" value="Dtur_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0490"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.515"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_2_0"/>
    <dbReference type="InParanoid" id="B8E205"/>
    <dbReference type="OMA" id="TEWMINN"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="134"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="757" mass="88786" checksum="7CFE48F7B1FAF8F1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E224</accession>
    <name>B8E224_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="8">Holo-ACP synthase</shortName>
            <ecNumber evidence="8">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">acpS</name>
        <name evidence="10" type="ordered locus">Dtur_1021</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583384.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352915.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1021"/>
    <dbReference type="EnsemblBacteria" id="ACK42301">
        <property type="protein sequence ID" value="ACK42301"/>
        <property type="gene ID" value="Dtur_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1021"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1058"/>
    <dbReference type="eggNOG" id="COG0736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089696_0_2_0"/>
    <dbReference type="InParanoid" id="B8E224"/>
    <dbReference type="OMA" id="DERHYAV"/>
    <dbReference type="OrthoDB" id="1893660at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACPS" evidence="9">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="126" mass="14521" checksum="71541D4687C6FAAC" modified="2009-03-03" version="1">MENISLEVGLDIIEIERIKNACEKHRNFKERIYSHEELKQLGNKKDIYASLAARFAAKEAFIKALGGKYEGWRWKDIEILYGLNGKPEIRLKNKALEMALQKGVKEIKVSLSHTHKYAVAIVILVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E240</accession>
    <name>EFP_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor P</fullName>
            <shortName evidence="1">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">efp</name>
        <name type="ordered locus">Dtur_1037</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583400.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352931.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E240"/>
    <dbReference type="SMR" id="B8E240"/>
    <dbReference type="STRING" id="515635.Dtur_1037"/>
    <dbReference type="EnsemblBacteria" id="ACK42317">
        <property type="protein sequence ID" value="ACK42317"/>
        <property type="gene ID" value="Dtur_1037"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1037"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1074"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_1_0"/>
    <dbReference type="InParanoid" id="B8E240"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000117894" description="Elongation factor P">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <sequence length="185" mass="20968" checksum="E1BFA876D18E3036" modified="2009-03-03" version="1">MISVNDFYPGLTIELEGEIYIVLEYQHVHMAQGQATVRVKLKNLKTGNVIRKTFKSDEYVPQAFINKREAEYLYKQGDEYYFIDNESFEQYILTEEQLGDAIKYLKEGNTVSVLFYEGNPIGIELPTTVVLEVVETDPGLRGDTVSGGSKPAKLETGLVIQVPLFIQIGDKVVVDTRYAKYVERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E241</accession>
    <name>B8E241_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1038</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583401.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352932.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1038"/>
    <dbReference type="EnsemblBacteria" id="ACK42318">
        <property type="protein sequence ID" value="ACK42318"/>
        <property type="gene ID" value="Dtur_1038"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1038"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1075"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_2_0"/>
    <dbReference type="InParanoid" id="B8E241"/>
    <dbReference type="OMA" id="TAYWAPE"/>
    <dbReference type="OrthoDB" id="1938042at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="147" mass="16540" checksum="58A1B06279FF64FF" modified="2009-03-03" version="1">MREWNLEDLKEIINLFSKSNLSELIIENGENKLILKRGDNVVNIISDQEIKKEQETKGISTREEEGVYITAPLVGVFYRSPAPGAPPFVEEGDLVEPGQTVCIIEAMKLMNEIKSHVRGRVKKVLVENGQAVEFGQKLFLIETESNV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E280</accession>
    <name>MUTL_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutL</name>
        <name type="ordered locus">Dtur_1078</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583440.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352971.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E280"/>
    <dbReference type="SMR" id="B8E280"/>
    <dbReference type="STRING" id="515635.Dtur_1078"/>
    <dbReference type="EnsemblBacteria" id="ACK42357">
        <property type="protein sequence ID" value="ACK42357"/>
        <property type="gene ID" value="Dtur_1078"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1078"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1114"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_1_0"/>
    <dbReference type="InParanoid" id="B8E280"/>
    <dbReference type="OMA" id="AHERIMY"/>
    <dbReference type="OrthoDB" id="764332at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000192170" description="DNA mismatch repair protein MutL">
        <location>
            <begin position="1"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <sequence length="572" mass="66262" checksum="DFB0E222A7A2F419" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E287</accession>
    <name>B8E287_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583447.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352978.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1085"/>
    <dbReference type="EnsemblBacteria" id="ACK42364">
        <property type="protein sequence ID" value="ACK42364"/>
        <property type="gene ID" value="Dtur_1085"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1085"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074761_1_1_0"/>
    <dbReference type="InParanoid" id="B8E287"/>
    <dbReference type="OMA" id="DEYLFPW"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011152">
        <property type="entry name" value="Pesterase_MJ0912"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000883">
        <property type="entry name" value="Pesterase_MJ0912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="243" mass="28699" checksum="78D5910BEA4FB4E9" modified="2009-03-03" version="1">MKIGIISDVHSNLPALEKVYKNLEREVDEIYFLGDIVGYGPFPNECMDYLKKFRHKVIGNHDAATVGMRGYDDFNEYARFAIDWTKENISKENIEKLKNLPQIEELEDSYLVHGSLRDPLDEYLINYYSVFANFELMNKNIAFFGHTHLTGVFIFSEKDKEIYYVSFVNGGELKIERGYKYLINPGSVGQPRDGNWKSSYAVYDTRLKVIEFYRVEYNLENLQKYMKMLGFPKYLWERLQYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2B7</accession>
    <name>B8E2B7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583477.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353008.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1115"/>
    <dbReference type="EnsemblBacteria" id="ACK42394">
        <property type="protein sequence ID" value="ACK42394"/>
        <property type="gene ID" value="Dtur_1115"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1115"/>
    <dbReference type="HOGENOM" id="CLU_1382194_0_0_0"/>
    <dbReference type="OMA" id="FEFIIGR"/>
    <dbReference type="OrthoDB" id="2120054at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="197" mass="22852" checksum="97BA263C9D17DE1E" modified="2009-03-03" version="1">MKVETKRLLFLSLYLILLLYVGGCIRPIQVFPQSTTINGVTINVEIIRDFKWYSLSQDIMVLNLEVINNSNEGIWIYPLGKSVIISANGRQYMPIREFYYQSTGAPKVSFEVSFKSNEPPSFSLLLSSNDEEKKINELIKTYELLKFKDGKVFPGARVSGILAFYTPYVKYPLRFIIPEVFWENSLQKYDFEFIIGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2D3</accession>
    <name>PGK_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgk</name>
        <name type="ordered locus">Dtur_1131</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583493.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353024.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2D3"/>
    <dbReference type="SMR" id="B8E2D3"/>
    <dbReference type="STRING" id="515635.Dtur_1131"/>
    <dbReference type="EnsemblBacteria" id="ACK42410">
        <property type="protein sequence ID" value="ACK42410"/>
        <property type="gene ID" value="Dtur_1131"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1131"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1168"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_0"/>
    <dbReference type="InParanoid" id="B8E2D3"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000192829" description="Phosphoglycerate kinase">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <sequence length="396" mass="43488" checksum="9EDAFADA712A7A97" modified="2009-03-03" version="1">MAKKTILDLRDEDLKGKRVLVRVDFNVPLKNGVITDDRRIREALPTIKYLMDKGAKVILVSHLGRPKGFQDDLRLDPVAKRLSELLGKPVKKLNDCIGEEVEREISNMKEGDVILLENIRFYKEEEANDPEFAKKLASLADLYVNDAFGTAHRAHASTAGVAQYIPGVAGLLMKKEIEIMGKALESPERPFICILGGAKVSDKIGVIKNLMNKVDGFLIGGGMMFTFLKALGYEIGKSIVEEDKLDLAREIMNMAKERGIQFLLPKDAVVVKEIKEDAPTSIKDIDKFEKDDIGVDIGPKTIELFREEILKAKTIIWNGPMGIFEIPAFANGTRKIAEAIAENRNCVSIVGGGDSAAAIQTLGLEDKFTHISTGGGASLEFLEGKELPGVAVLQDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2G4</accession>
    <name>TRMD_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmD</name>
        <name type="ordered locus">Dtur_1534</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583884.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353422.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2G4"/>
    <dbReference type="SMR" id="B8E2G4"/>
    <dbReference type="STRING" id="515635.Dtur_1534"/>
    <dbReference type="EnsemblBacteria" id="ACK42808">
        <property type="protein sequence ID" value="ACK42808"/>
        <property type="gene ID" value="Dtur_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1534"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1583"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2G4"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000130162" description="tRNA (guanine-N(1)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <sequence length="245" mass="28200" checksum="2F1A64EA66E4FCAA" modified="2009-03-03" version="1">MLRIDIVTIFPEMFKGPFDVSILKKAQDKGLVEIKVYNLRDFTEDKHRTVDDYPYGGGSGMVMKPEPIFKAVRSLKKEDSEVILLSPSGDLFNQKIAEELSKKNHLILICGRYEGVDERVKSIITREISIGDYVLTGGEIPAMVIVDAVVRLVPGVLGDPDSLREESFQWGILEYPQYTHPRDFEGMKVPDILLSGNHERIRRWRRKEALKKTFLKRPDLLEKTSLTQEDLELLEEIKKELREEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2H7</accession>
    <name>B8E2H7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA gyrase subunit B</fullName>
            <ecNumber evidence="10">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gyrB</name>
        <name evidence="12" type="ordered locus">Dtur_1547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583896.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353435.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1547"/>
    <dbReference type="EnsemblBacteria" id="ACK42821">
        <property type="protein sequence ID" value="ACK42821"/>
        <property type="gene ID" value="Dtur_1547"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1547"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1596"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_0"/>
    <dbReference type="InParanoid" id="B8E2H7"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="418"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="635" mass="72223" checksum="29E415B07D0C2A2B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2K1</accession>
    <name>PYRF_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">OMP decarboxylase</fullName>
            <shortName evidence="1">OMPDCase</shortName>
            <shortName evidence="1">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrF</name>
        <name type="ordered locus">Dtur_1571</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583920.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353459.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2K1"/>
    <dbReference type="SMR" id="B8E2K1"/>
    <dbReference type="STRING" id="515635.Dtur_1571"/>
    <dbReference type="EnsemblBacteria" id="ACK42845">
        <property type="protein sequence ID" value="ACK42845"/>
        <property type="gene ID" value="Dtur_1571"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1571"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1619"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067069_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2K1"/>
    <dbReference type="OMA" id="NFKIFLD"/>
    <dbReference type="OrthoDB" id="1150446at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_B">
        <property type="entry name" value="OMPdecase_type1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000164567" description="Orotidine 5'-phosphate decarboxylase">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <sequence length="244" mass="27981" checksum="4BB3B1F3718D9635" modified="2009-03-03" version="1">MRKYYPIIVALDFPEEKRALEIAEKLVPYIKNFKVGLELFSVAGPHIVKALKEMGTNVFIDLKLFDIPNTVVRTLDRLLALEPFMVTLHILGGEEMLRESVKLVSQYKESNKTEYPYLLGVTVLTSFNEETLRRSWGISRSLPEQVLFLAQLAQETGLDGVIASPWEIELLRNNLKRPMLIVTPGIRLTKEKTDDQQRIMTPREALERGSDYLVIGRPITQSPDPYEVIQNIRSQIEDIVESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2L6</accession>
    <name>B8E2L6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583935.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353474.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1587"/>
    <dbReference type="EnsemblBacteria" id="ACK42860">
        <property type="protein sequence ID" value="ACK42860"/>
        <property type="gene ID" value="Dtur_1587"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1587"/>
    <dbReference type="HOGENOM" id="CLU_1406798_0_0_0"/>
    <dbReference type="OMA" id="GINFAKW"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867831" evidence="1">
        <location>
            <begin position="24"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="193" mass="21960" checksum="ABFB955EF707D25D" modified="2009-03-03" version="1">MKKVVLISLISLLLLTVSFSQSVKEIVIYDGETENTNLSALGYWIAPEGCKVEEMEGIAYSGKKCLKIDFVWNSWWAGMGINFAKWNFEDKDKILDLSNYKALEFYIRAEKLDNYNLLVTIVEAPAQKDGKEFYSEKYTVMGGVPTQWTKVSIPLKSFVTVDKKRIWGMSIEVTGIPEGKAVLYVDNIKFVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2M2</accession>
    <name>B8E2M2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583941.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353480.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1593"/>
    <dbReference type="EnsemblBacteria" id="ACK42866">
        <property type="protein sequence ID" value="ACK42866"/>
        <property type="gene ID" value="Dtur_1593"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1593"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1643"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="InParanoid" id="B8E2M2"/>
    <dbReference type="OMA" id="FPYLING"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="299" mass="34494" checksum="872EC655D3E4DFCA" modified="2009-03-03" version="1">MREKFRDLWKEVKKNKESYFLLLPYFTLFFTFVVIPVIVGAVLSFTNYNIIQVPKFIGWNNYKRLFLEDDVFLIALQNTFKFALITGPLSYFACLFFAWLINELPPRIRAVLTLLYYAPALSSAIFFIWTYIFSGDVYGLLNGFLMNLGIIKEPIYWLQDSRINLYVLMVIQLWMSLGTSFLAFIAGFQTIDKSLYEAAAVDGIRNRWQELWYITLPSMKPQLIFGAIMQVTSSFAVADISAQLIGFPSPLYSAHTIVLHMWDYGSIRYEMGYASAIAVILFLITVAINQGVRKIIRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2N9</accession>
    <name>B8E2N9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diacylglycerol kinase catalytic region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583958.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353497.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1610"/>
    <dbReference type="EnsemblBacteria" id="ACK42883">
        <property type="protein sequence ID" value="ACK42883"/>
        <property type="gene ID" value="Dtur_1610"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1610"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1659"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2N9"/>
    <dbReference type="OMA" id="GFDSRVN"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005218">
        <property type="entry name" value="Diacylglycerol/lipid_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00147">
        <property type="entry name" value="TIGR00147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="287" mass="31912" checksum="3F38591F2087FB92" modified="2009-03-03" version="1">MKYHILFNPTSNRGRAGKRYHELVNVLEEENLDYTIEFTLGKEGTIKQVEEALRRGVDVVVAAGGDGTINEVVNGLKGRGILGIIPLGRGNDIAISYRIPRDIRKAVKLLKNGIIKEVDIGLLDGRYFVGIAGTGFVGDVNYNSNKLNLTGFKGYLISVFTTLKEFKYPECEVSFDGISWKGRITLIALGNTSYYGGGMKLLPTSDPEDGYFDVGIAQKIHPIELILTFPLVYLGKHTINPHIKIYRGREVRIASDQDLIISFDGEMIVSKEIKFTNVPKFQKVIRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2P3</accession>
    <name>RUVC_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="1">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvC</name>
        <name type="ordered locus">Dtur_1614</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583962.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353501.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2P3"/>
    <dbReference type="SMR" id="B8E2P3"/>
    <dbReference type="STRING" id="515635.Dtur_1614"/>
    <dbReference type="EnsemblBacteria" id="ACK42887">
        <property type="protein sequence ID" value="ACK42887"/>
        <property type="gene ID" value="Dtur_1614"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1614"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1663"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_3_1_0"/>
    <dbReference type="InParanoid" id="B8E2P3"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000195249" description="Crossover junction endodeoxyribonuclease RuvC">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <sequence length="158" mass="17337" checksum="03962668940567B3" modified="2009-03-03" version="1">MVVIGFDPGTAITGYGILNKGEDGISIIEYGALTTPSGWGIGRRLNYLFDQVSSLLDLYNPDVVVMENIFFNKNIKTAINIGQAQGVIILAAEQHQKEISILTPLEVKLSVVGYGRATKNQIQYMVKEILKLKDIPKPDDVADALALCISYIYKQEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2P9</accession>
    <name>B8E2P9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutamine--fructose-6-phosphate transaminase (Isomerizing)</fullName>
            <ecNumber evidence="3">2.6.1.16</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.6.1.16" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583968.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353507.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1620"/>
    <dbReference type="EnsemblBacteria" id="ACK42893">
        <property type="protein sequence ID" value="ACK42893"/>
        <property type="gene ID" value="Dtur_1620"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1620"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1669"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_2_1_0"/>
    <dbReference type="InParanoid" id="B8E2P9"/>
    <dbReference type="OMA" id="QSFYVMA"/>
    <dbReference type="OrthoDB" id="1046291at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="30"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="192"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="344" mass="39028" checksum="16836BE260B6F34C" modified="2009-03-03" version="1">MSEKFMIKEIREGFSIIKSYKDRWEEFVEVSKRIKSLDFQNIVFVARGSSDNAATWGKYYMESHLRVPVSLCAPSLFTIYKLPPNLKSSLVIAISQSGESDDICEVVNNANKQGALTIGITNNPQGKLAQIAKINIFLNSGIEKSVAATKTYLSQLVSIYFLTNTLIGRNILPEFDKILNAMEDILKREEEIKEKVKPYKYMEHCAVLGRGFNLSTALETALKLKETSYIIAQPYSSADFMHGPLALASEGFPVFFFVPKGESMEHSLEVLKTLKEKGSDIFIFTNEIDLLKEYDGIYINCDIPEYITPIPFIYPAQFFAYYLAEIKGRDPDNPRNIRKVTITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Q8</accession>
    <name>B8E2Q8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homocitrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein is a Fe-Mo-cofactor biosynthetic component.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583977.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353516.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1629"/>
    <dbReference type="EnsemblBacteria" id="ACK42902">
        <property type="protein sequence ID" value="ACK42902"/>
        <property type="gene ID" value="Dtur_1629"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1629"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1678"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_4_2_0"/>
    <dbReference type="InParanoid" id="B8E2Q8"/>
    <dbReference type="OMA" id="SNMFAHE"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07939">
        <property type="entry name" value="DRE_TIM_NifV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013477">
        <property type="entry name" value="NifV/FrbC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02660">
        <property type="entry name" value="nifV_homocitr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="382" mass="42249" checksum="3F0F0D9F0198E300" modified="2009-03-03" version="1">MKNTEIKIVDTTLRDGEQTAGVVFSKAEKLQIARMLDEIGVHQIEAGIPVMGGDEEEAIKAIVKAGLKASIMGWNRAVISDIEASLRCGVDAVAISISTSDIHIKYKLKKTREWVLESMVKATEFAKKHGVYISVNAEDASRTDMDFLLQFAKAAKEAGADRLRYCDTVGIMEPFTMYEVIKTIIEKVGIPVEMHTHNDFGMATANALAGVRAGATYVGVTVNGLGERAGNAALEEVVMALKYIYNIDVGIKTYKLRELSEYVAKASQRELPVNKAIVGKNIFAHESGIHADGVIKYPKTYEVFSPEEVGGERQIVIGKHSGTHALIRKFQEYGITLSEEDAQELLKKVRALAVELKRPLFDKELMYLYQDYLKEKAEKEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Y5</accession>
    <name>B8E2Y5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nusA</name>
        <name evidence="9" type="ordered locus">Dtur_1206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583567.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353099.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1206"/>
    <dbReference type="EnsemblBacteria" id="ACK42485">
        <property type="protein sequence ID" value="ACK42485"/>
        <property type="gene ID" value="Dtur_1206"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1206"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1244"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_0"/>
    <dbReference type="InParanoid" id="B8E2Y5"/>
    <dbReference type="OMA" id="MDIDMSA"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="137"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="360" mass="40977" checksum="8E0C3BA839414EA6" modified="2009-03-03" version="1">MKLGEDFWVVLEQIITEKKLDKNVVLEALRKALLSAFKKAYGTSKGARVEINFNKQEINIYVVKKIVEKVNDNISEISLEEAKSLKPDAKIGDEIEIEIEPQEFGRIAVQVAKQVIMQSLKEAERKILYEKYKAKEGELVNGTVVRVEKGNVYVRFPDIEAILPVKEQIPGEEYWIGRRLRAYLLEVRKTTKDPLVILSRSHPGFLKRLFELEVPEIREGTVEIVSIAREPGMRSKVAVYSHLPEVDPIGACVGYKGVRIQNIINELNGEKIDIVLWSKDPAEFVARSLSPAKPLSVEIREDEHKAIVIVPPDQFSLAIGKDGQNVRLAVKLTSWRIDVRTPEQYAKEKEEKEKVVEKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Z0</accession>
    <name>B8E2Z0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase RecJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583572.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353104.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1211"/>
    <dbReference type="EnsemblBacteria" id="ACK42490">
        <property type="protein sequence ID" value="ACK42490"/>
        <property type="gene ID" value="Dtur_1211"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1211"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1249"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2Z0"/>
    <dbReference type="OMA" id="YTGIMTD"/>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="185"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="332" mass="38002" checksum="6AAF179BF6853474" modified="2009-03-03" version="1">MKNIRNKTLRVLKTVIEENQDFILFTHQNPDGDAIGSVLAFYYFLEELNKNPTIYMTGVVPYFYEFLLKKEVKIVKEIDRKYEVGIVFDSSDKNRITEEFDISEKVKVLINIDHHPTNSNFGNINIVNPKAASVTEIISDIIKKLGYEISINVAECILTGLITDTGSFKFSNTNYKSLKIASDLVKKGANISKISKEIYEKRKMASLKLMGIALLRLQLYRNIGWSFIEEEDMKVNGASQEDIEGIIDLLRTLKEADLVVLFYPYNKEKIKVSLRSKKDSIDVSRLALKFGGGGHKEAAGFQIDKTQMNSYDDFIKKIDSYINSDEWVYTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8E315</accession>
    <name>B8E315_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component transcriptional regulator, winged helix family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583597.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353129.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1237"/>
    <dbReference type="EnsemblBacteria" id="ACK42515">
        <property type="protein sequence ID" value="ACK42515"/>
        <property type="gene ID" value="Dtur_1237"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1237"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_0"/>
    <dbReference type="InParanoid" id="B8E315"/>
    <dbReference type="OMA" id="LMREVWD"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="126"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="232" mass="26910" checksum="BF06F4E2D92C036E" modified="2009-03-03" version="1">MKKILLVEDDKGIVNSLTLLLNKEGYEVEVAYDGVEALNKFKLFNPDLVLLDIMLPEKDGWEVCKEIRKISNVPIIMLTAKDEEVDKVLGLKMGADDYITKPFGAKELLARIEAVLRRYQSDLSKSQKIVAPPFEMDLVKRTVKVKGKEVNLSYREFEILKLLLSSPGRVWTRDMIIKHIWGENFWGEPRAVDVYIRWLREKVEDDPSHPKYIITVRNLGYKFQEGNENKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E326</accession>
    <name>B8E326_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583608.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353140.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1248"/>
    <dbReference type="EnsemblBacteria" id="ACK42526">
        <property type="protein sequence ID" value="ACK42526"/>
        <property type="gene ID" value="Dtur_1248"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1248"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1288"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_1_0_0"/>
    <dbReference type="InParanoid" id="B8E326"/>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="361" mass="41186" checksum="E206DF03BC4235F7" modified="2009-03-03" version="1">MKKYDKLIFILALILSLLSLPIIHTASWRWASLTLNNSSYFFQHQLIYLPLAIGISFIVSAFSLDFWRKNSLLLLLISLFLLILVFIPPFGKVSRNVARWIEIGPIQIQPVEVLRFSWIIFLASFLSSNSEKKRIDGARFLWIILFLLLISIVLYFQPNMSMIVLFFLSTFVILFVSKMNFKQVLVMLLIISLVFSFGILTGEYRKERLVLNKGIPFFKTFQQEQALKAIKDGGIFGKGWGRGVLKFYIPEAYNDFLLPVIYEEGGLMAGTVILMLYFFLMLTLFNLSIKASKTDVFSGLLSMGVLVYWCVEIILNILMNLGFLPVMGLPLPFLSFGGSSMMVNWAQVGLLMKIAILGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E338</accession>
    <name>B8E338_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583987.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353526.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1639"/>
    <dbReference type="EnsemblBacteria" id="ACK42912">
        <property type="protein sequence ID" value="ACK42912"/>
        <property type="gene ID" value="Dtur_1639"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1639"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_6_0_0"/>
    <dbReference type="InParanoid" id="B8E338"/>
    <dbReference type="OMA" id="IAHPIAG"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="184" mass="21506" checksum="357CAC076F99A46E" modified="2009-03-03" version="1">MEVKRIIQERRSLRSLEPFEVTQELIYDLAESASLAPSCFNNQPWRFIFTYDQNILKELYTALTPRNNWAYKSPLIVTVFTKDELDCQIKGRNYALLDTGMAVGFMLLRATELGLIAHPIAGYDEEKVKKILNIPEDMTAILLIVFGKQAKEINPNLSEEQKERELKRPERLPIKDFVYFNKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E350</accession>
    <name>B8E350_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DOMON domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353538.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1651"/>
    <dbReference type="EnsemblBacteria" id="ACK42924">
        <property type="protein sequence ID" value="ACK42924"/>
        <property type="gene ID" value="Dtur_1651"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1651"/>
    <dbReference type="eggNOG" id="COG4902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115706_0_0_0"/>
    <dbReference type="InParanoid" id="B8E350"/>
    <dbReference type="OMA" id="WISIGFQ"/>
    <dbReference type="OrthoDB" id="1763090at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004500">
        <property type="term" value="F:dopamine beta-monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000945">
        <property type="entry name" value="DBH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10157">
        <property type="entry name" value="PTHR10157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOMON" evidence="1">
        <location>
            <begin position="46"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="185" mass="20977" checksum="DDED078744C4DC56" modified="2009-03-03" version="1">MEGILKILILSLILLLTFTFAQTQKPNIDGKLSPNEYPNYASFSNGEFQIYWKIVGDEVYILMTGKTKGYVALGIDPKVKAGDADYIIGYVTEKGTQVLDYYAPEKHFGHTQDEKLGGKNDIPEFSGREDKEYTYIEFRRKLDTKDKYDKVFPKTGTLKIVWALGSSDDPVSIHSKRGYGELKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E384</accession>
    <name>B8E384_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="13">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_1686</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="13"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584033.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353572.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1686"/>
    <dbReference type="EnsemblBacteria" id="ACK42958">
        <property type="protein sequence ID" value="ACK42958"/>
        <property type="gene ID" value="Dtur_1686"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1686"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_0"/>
    <dbReference type="InParanoid" id="B8E384"/>
    <dbReference type="OMA" id="CREGTDW"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="12">
        <location>
            <begin position="439"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="545" mass="59930" checksum="433006A42E46B616" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E385</accession>
    <name>B8E385_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH-quinone oxidoreductase, E subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584034.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353573.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1687"/>
    <dbReference type="EnsemblBacteria" id="ACK42959">
        <property type="protein sequence ID" value="ACK42959"/>
        <property type="gene ID" value="Dtur_1687"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1687"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_0"/>
    <dbReference type="InParanoid" id="B8E385"/>
    <dbReference type="OMA" id="LRPVYCL"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="153" mass="17561" checksum="EE3FCA0D4247C488" modified="2009-03-03" version="1">MKTRQEILESFPRDPDYIIEILHELQNNNPYNYLTPEDIKACAEYLELPVSYVEGVASFYSMFSLKPRGRYVIRLCDSPPCHLVGSESLLEYLERKLNIKVGETTEDRVFTLEVTSCLGVCAVAPAMMINDEVYGNLTFEKIDKILEEKRGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E387</accession>
    <name>B8E387_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protease PrsW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_1689</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protease PrsW family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584036.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353575.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1689"/>
    <dbReference type="EnsemblBacteria" id="ACK42961">
        <property type="protein sequence ID" value="ACK42961"/>
        <property type="gene ID" value="Dtur_1689"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1689"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1740"/>
    <dbReference type="eggNOG" id="COG2339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081250_1_0_0"/>
    <dbReference type="InParanoid" id="B8E387"/>
    <dbReference type="OMA" id="DEPYDGI"/>
    <dbReference type="OrthoDB" id="1626415at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023596">
        <property type="entry name" value="Peptidase_PrsW_arch/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36844">
        <property type="entry name" value="PTHR36844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016933">
        <property type="entry name" value="PrsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="224" mass="25871" checksum="79CD468526CBA872" modified="2009-03-03" version="1">MGLIILALAPGISIAWYVYNKDKWNKEPSKLILWSFILGVIISFPAAIFELIMESIIPFNFNSDFVSLFLYSLLGIAIIEEGTKYYVIYKYIYPKEEFDEPFDGIVYSVMVGMGFATIENFFYVISGGYFVGITRAFLAVPAHFVFSLFMGYSFGLAKFGANPEKHLLQALYYPVFWHALYDFLIITQKWYLSILILPIVYGVGRWIWKKGQKLIIFKSEEEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3A1</accession>
    <name>B8E3A1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584050.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353589.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1703"/>
    <dbReference type="EnsemblBacteria" id="ACK42975">
        <property type="protein sequence ID" value="ACK42975"/>
        <property type="gene ID" value="Dtur_1703"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1703"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_2_0"/>
    <dbReference type="InParanoid" id="B8E3A1"/>
    <dbReference type="OMA" id="IQERHIS"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="102"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="638" mass="73610" checksum="DEA0885422420110" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3C2</accession>
    <name>B8E3C2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584071.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353610.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1724"/>
    <dbReference type="EnsemblBacteria" id="ACK42996">
        <property type="protein sequence ID" value="ACK42996"/>
        <property type="gene ID" value="Dtur_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1724"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1776"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_3_0"/>
    <dbReference type="InParanoid" id="B8E3C2"/>
    <dbReference type="OMA" id="NTPWTYY"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBP_bac_5" evidence="1">
        <location>
            <begin position="80"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="625" mass="71900" checksum="54FDB74AB710250C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3D3</accession>
    <name>B8E3D3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-N-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584082.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353621.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1735"/>
    <dbReference type="CAZy" id="GH51">
        <property type="family name" value="Glycoside Hydrolase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK43007">
        <property type="protein sequence ID" value="ACK43007"/>
        <property type="gene ID" value="Dtur_1735"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1735"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1787"/>
    <dbReference type="eggNOG" id="COG3534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017810_1_1_0"/>
    <dbReference type="InParanoid" id="B8E3D3"/>
    <dbReference type="OMA" id="SKYMRGW"/>
    <dbReference type="OrthoDB" id="620389at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-AF_C" evidence="3">
        <location>
            <begin position="300"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="514" mass="59223" checksum="546C6F2011FA2109" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYH8</accession>
    <name>B8DYH8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582446.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351974.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41360">
        <property type="protein sequence ID" value="ACK41360"/>
        <property type="gene ID" value="Dtur_0019"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0019"/>
    <dbReference type="HOGENOM" id="CLU_762327_0_0_0"/>
    <dbReference type="OMA" id="ESKLMIG"/>
    <dbReference type="OrthoDB" id="2109737at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867679" evidence="1">
        <location>
            <begin position="20"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="363" mass="37876" checksum="3A21E1864841A250" modified="2009-03-03" version="1">MKRFVWLLVLALLVVPAFAANVSTSSWIGVGFHTRFLPFSDGYGFAWGTWGSGNLTFSLSGSSNLGSVNATFKVNLPYDLSGSASPTGTITFAKLFNNPLTLSFYKGTFGGLSTRLVGNVVSSTAISVVADMAPVKVTVAYAPADTWWKSNLWADAALAVKAEASLSTPVSVSLYGLINKAATYTTISAWAVGGSVTPVTAPVSLTVCGEAASNPEQLIGVTVKAVEGKVTVNGNYKLQAKTFKVSVTADKVVPNTTVYAEYNTAETYTIFGYVSASAPVPVGSLSLGAALANGPDTLVGGFAKWSVSLGGGVSHDLLLGYGFDYDDYSANGFNRGNLTGADNLWGVDVRGKFYAESKLMIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYJ0</accession>
    <name>B8DYJ0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin-like protein, YruB-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582458.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351986.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0034"/>
    <dbReference type="EnsemblBacteria" id="ACK41372">
        <property type="protein sequence ID" value="ACK41372"/>
        <property type="gene ID" value="Dtur_0034"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0034"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026126_9_3_0"/>
    <dbReference type="InParanoid" id="B8DYJ0"/>
    <dbReference type="OMA" id="IFTTPTC"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011911">
        <property type="entry name" value="GlrX_YruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02196">
        <property type="entry name" value="GlrX_YruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="81" mass="9331" checksum="58E79EEC17F06058" modified="2009-03-03" version="1">MSSNLRIIVYSTPSCPWCNAAKRYFRERGIRFYDVDVSKDRKAAEEMVRKSGQMGVPVIDINGHIVIGFDRNKIDRLLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYP0</accession>
    <name>B8DYP0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0084</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352036.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0084"/>
    <dbReference type="EnsemblBacteria" id="ACK41422">
        <property type="protein sequence ID" value="ACK41422"/>
        <property type="gene ID" value="Dtur_0084"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0084"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.85"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_8_0_0"/>
    <dbReference type="InParanoid" id="B8DYP0"/>
    <dbReference type="OMA" id="LWPEMAP"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="289" mass="33029" checksum="C4531C6499F716A1" modified="2009-03-03" version="1">MRKLIGLFYDLLKDYRFTISFIIFLFLIILAILSFFSPYNPQRTYQVPSGLPPSKNHILGTNWLGQDVFWQLTFAVKNSLTIAIVTAFFSRIIAVIVGIFAGYKGGKTDRILITVGDTTMVLPFLIILIIISMILKDWTNNFFNLGLLLAFFSWAWDARVIRSQILSLRERDFIKVAVLSGMPTMRIVRKQLLPHVLPIIFTTFINNMSWAIGMEITLAYLGLGIDPTIPTIGTMLQTAIYRQALFMGLWWWLATPIVTAILLFIALYWLSVSLSEYLDPRARFQRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYQ0</accession>
    <name>B8DYQ0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352046.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0094"/>
    <dbReference type="EnsemblBacteria" id="ACK41432">
        <property type="protein sequence ID" value="ACK41432"/>
        <property type="gene ID" value="Dtur_0094"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0094"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYQ0"/>
    <dbReference type="OMA" id="KWIVVIN"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="388" mass="44660" checksum="77ABC9FBA2D6A1C6" modified="2009-03-03" version="1">MMIFKNSIYFFKSALRERAYVFWCVVFPVILMVILITIFSSMYKVEKVNFEVYLIKSESGEFSNIIFQVFEDLSKGENKVFNLKVFKDDSLKDKLIEDLKRGRTKLIVEIPEGFDSLVISNISMKMLGLGENSAPLKVYILKHNVSSQAASMVVRNIVDRLNLEFAKRMSKIKEYEVKTEIVGSKTGFSYVDFIYPGIVILAIFFTGLFGIGQELTWYREGKILKRFRITPISSLNFFFSYFLSRLYLFILQALIVTFVGKVLYKSSVNFLSFYFFLYVFLAMLSLSSMGFFISAFSKNTNSAGVIGQILNFPLQFLGGIYFPVSDVPWFIKWIVVINPITYLAAGIRDTLGITPSPYPIYLTIVVPLIYTALFLFISIRKYKRVELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYQ2</accession>
    <name>B8DYQ2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582520.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352048.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0096"/>
    <dbReference type="EnsemblBacteria" id="ACK41434">
        <property type="protein sequence ID" value="ACK41434"/>
        <property type="gene ID" value="Dtur_0096"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0096"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.99"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_0"/>
    <dbReference type="InParanoid" id="B8DYQ2"/>
    <dbReference type="OMA" id="NAHDKEY"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="243" mass="28284" checksum="02764E9CE1812827" modified="2009-03-03" version="1">MRLDKFLVNQGFGSRKEVQKLIKAGIVYVNNFPVEDPSFHINPEKDVVEIEGQEIEYKENYYFMLNKPKGYITATYDENYPTVMDLFASEPIVSKLFPVGRLDVDTEGLLIITSDGVLAHRLSHPKWNVEKEYFVIVEGDISDIDFSKYEKEGMYLKKEKYKTKPFKVKVLKTSFEESELLITITEGKYHIVKKIMYAVGHEVKYLKRVRIGPLILDEDLEVGEYRELTKEEISLLKSYVKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYR4</accession>
    <name>B8DYR4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352060.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41446">
        <property type="protein sequence ID" value="ACK41446"/>
        <property type="gene ID" value="Dtur_0113"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0113"/>
    <dbReference type="HOGENOM" id="CLU_2034343_0_0_0"/>
    <dbReference type="OrthoDB" id="1530947at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="121" mass="14310" checksum="477EBEB387628D34" modified="2009-03-03" version="1">MGYHYTIWGVLKPLWDDRRVRIQIRMFESDSGLRGSQHKDEEMDIRTGAGKDFVFEFDPRDMSYSVSLGTKVWSIPAGFFIKSDGEGDLRARIYVKVWTMGDKKEEIFYPIMWYVPIKMRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYS4</accession>
    <name>B8DYS4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582541.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352070.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0124"/>
    <dbReference type="EnsemblBacteria" id="ACK41456">
        <property type="protein sequence ID" value="ACK41456"/>
        <property type="gene ID" value="Dtur_0124"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0124"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_4_0"/>
    <dbReference type="InParanoid" id="B8DYS4"/>
    <dbReference type="OMA" id="ICGTLAN"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="180" mass="20653" checksum="4A4833A5A0612AB6" modified="2009-03-03" version="1">MRPALIIVDMVVDFVTGKFGNPYVQEIVPNIKLLIDKAHEKKVPVIYLRDAHTEEDKELSLWGKHAMDGDKGSEIIPELAPQKDDYIIKKKVYSGFYKTELEDLLRGLNVDTVILTGTSTHICVLHNSADAFFRGFDIIVISDATASFVPEEHERALKYMKEIHNAKIYTTYELLERWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYT8</accession>
    <name>B8DYT8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0138</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582555.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352084.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0138"/>
    <dbReference type="EnsemblBacteria" id="ACK41470">
        <property type="protein sequence ID" value="ACK41470"/>
        <property type="gene ID" value="Dtur_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0138"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.143"/>
    <dbReference type="eggNOG" id="COG0219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110125_2_1_0"/>
    <dbReference type="InParanoid" id="B8DYT8"/>
    <dbReference type="OMA" id="AGLDYWH"/>
    <dbReference type="OrthoDB" id="1578095at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002131">
        <property type="term" value="P:wobble position cytosine ribose methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002132">
        <property type="term" value="P:wobble position uridine ribose methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="153" mass="17789" checksum="D9BF3DB764FAB216" modified="2009-03-03" version="1">MRYNLHVVLIEPQIPYNTGNIGRLCVATNSKLHLVGKIGFSLNDKYLKRAGLDYWSFLDYEVYKNFEEFVERNKNGRFIFVESPAFKLYTEVSYQEGDYLIFGSEDYGIPSEIIEKYWENSVTIPMFGPVRSLNLSSSVAVVVYEALRQIKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYU7</accession>
    <name>B8DYU7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease YjgP/YjgQ family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352093.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0148"/>
    <dbReference type="EnsemblBacteria" id="ACK41479">
        <property type="protein sequence ID" value="ACK41479"/>
        <property type="gene ID" value="Dtur_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0148"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_0_0"/>
    <dbReference type="InParanoid" id="B8DYU7"/>
    <dbReference type="OMA" id="ELQWRIA"/>
    <dbReference type="OrthoDB" id="47611at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="364" mass="42639" checksum="21227D61B883D8F7" modified="2009-03-03" version="1">MSMHIKTYHKYIFSEILGPFFLGIFGFILVMLIQILYEFSDFIIMRRVSFEVVLKLLYYKIPSLFVFVIPVSLLFAIIFSFGRLMRDGEIFAMRSSGIYFLSLTLTPLLFSILLSLILWFFTYSLIPESNYRSNRLIQKYFFLNPAPIKGENVFFHDEEGRYYYVKKIIENRNVMQNVLVFDTSSSNKYPIIYTAEEAIWNRDSLILKNGVVHHLGDDSFVVWEGKFEEFKINLPQDFMYIFYRDRTPQEMPTNELKKRINVYKKAGISARSYLVEDYLRIAQSIAVPIFALMGFSVILLTGRGGRLWGTAFSIIIAFFYYGFNIIARSFGEYAVFSPFLSAWLPNITLGSLSLGVFIWKVRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYX5</accession>
    <name>B8DYX5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582686.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352215.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0275"/>
    <dbReference type="EnsemblBacteria" id="ACK41601">
        <property type="protein sequence ID" value="ACK41601"/>
        <property type="gene ID" value="Dtur_0275"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0275"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.288"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155232_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYX5"/>
    <dbReference type="OMA" id="DVPWPLY"/>
    <dbReference type="OrthoDB" id="1069317at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="189"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="245" mass="28487" checksum="A3491F1A5FBBFF7A" modified="2009-03-03" version="1">MKNLFLILFLSVFVISNLFAIDFDTANKIFFEARRDRDVEKIKALISTLEGDKDLLTSSQLLTVLADSYLEYGLWGVEGKEKEKIYEKARSYAEKAIKLDPNNGRAWYIAGASIGRLAQYRGIVQSLFMLKDFDRYISKAIEILNDPLYRTFALLAMGMRYRDVPWPLYNYEKAESYMKEALKYTPIYPNIYLELGYLYLKMGKKDLAKEMFIRVVKSDPHPWLIKTHEESVNLAKKELEKLGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYX8</accession>
    <name>B8DYX8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582689.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352218.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0279"/>
    <dbReference type="EnsemblBacteria" id="ACK41604">
        <property type="protein sequence ID" value="ACK41604"/>
        <property type="gene ID" value="Dtur_0279"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0279"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068890_1_1_0"/>
    <dbReference type="InParanoid" id="B8DYX8"/>
    <dbReference type="OMA" id="FLGFPNW"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12682">
        <property type="entry name" value="Flavodoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="160" mass="18136" checksum="2D4E8929D75D539A" modified="2009-03-03" version="1">MSNILIVYYSWSGNTRKIAEIIQKETGGDVIEVIPENPYPSSYNATVEQAKKEIKMNYKPPIKTKVEDIEKYNIIFVGTPNWWSTIAPPIATFLSQHNLSGKNVIPFITHGGGGQGRIINDIKKLCPESKILEPFSTYEGGSKDLREKILEWLKKLQIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ04</accession>
    <name>B8DZ04_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium/calcium exchanger membrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582715.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352244.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0308"/>
    <dbReference type="EnsemblBacteria" id="ACK41630">
        <property type="protein sequence ID" value="ACK41630"/>
        <property type="gene ID" value="Dtur_0308"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0308"/>
    <dbReference type="eggNOG" id="COG0530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1341483_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ04"/>
    <dbReference type="OrthoDB" id="804531at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008273">
        <property type="term" value="F:calcium, potassium:sodium antiporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070588">
        <property type="term" value="P:calcium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:cellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004481">
        <property type="entry name" value="K/Na/Ca-exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10846">
        <property type="entry name" value="PTHR10846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Na_Ca_ex" evidence="6">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="204" mass="22619" checksum="BC18C78523B1CB0A" modified="2009-03-03" version="1">MGAILASIATTLPEISVSIISSFQGKGSLALGNALGSVLFNIAVILGISSVFRPIKVDDKGWRNALFLLILSGILGLMALNKYLSRWEGLVLIILYGIFLKRSIEKEEIYHQGKERKIVLMDIAYVFIMGGVVVLGSKFLVDSDDYWTYNCGFWNLLTRICQYSYLHKAFCSNKSYLNGKGVFILSTTYSSIGVFFFNGLPKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ11</accession>
    <name>B8DZ11_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582722.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352251.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0316"/>
    <dbReference type="EnsemblBacteria" id="ACK41637">
        <property type="protein sequence ID" value="ACK41637"/>
        <property type="gene ID" value="Dtur_0316"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0316"/>
    <dbReference type="eggNOG" id="COG2250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_2_1_0"/>
    <dbReference type="InParanoid" id="B8DZ11"/>
    <dbReference type="OMA" id="NWACFKA"/>
    <dbReference type="OrthoDB" id="2025059at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="130" mass="15343" checksum="B1600150B35FD43F" modified="2009-03-03" version="1">MNRSDDWLKQAKRDYEKALLDYEHSFYEWACFASQQSAEKAVKALYYKLNRAVKGHSIVKMLDGLKELIDVSDEIYHRARILDRYYKESRYPNGFPEGSPYEFFDKKIAEEALNAAREIIGFCEDIISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ12</accession>
    <name>B8DZ12_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582723.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352252.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0317"/>
    <dbReference type="EnsemblBacteria" id="ACK41638">
        <property type="protein sequence ID" value="ACK41638"/>
        <property type="gene ID" value="Dtur_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0317"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_9_2_0"/>
    <dbReference type="InParanoid" id="B8DZ12"/>
    <dbReference type="OMA" id="RTGICIY"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="121" mass="14110" checksum="E0D84A55FF97A25C" modified="2009-03-03" version="1">MLHEKLLGSVKILSVDYDALINKLKEISFFIKEKNSKVIKIMLFGSFARGDYTPESDVDIMIIVKNSEKPFLFRADEFLDYFKEVPFDVNIIVYTKDEIEKMEKDNNIFIKEVLSYAVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ38</accession>
    <name>B8DZ38_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582749.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352278.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0352"/>
    <dbReference type="EnsemblBacteria" id="ACK41664">
        <property type="protein sequence ID" value="ACK41664"/>
        <property type="gene ID" value="Dtur_0352"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0352"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_908306_0_0_0"/>
    <dbReference type="OMA" id="PENIIHY"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="306" mass="35830" checksum="E6DC8B6525A68694" modified="2009-03-03" version="1">MILVVGGSSFIGRGIQDLIKEKPFAKEFIFTYNKHPENIENKFQKVKLDLQDEKDCELARNFSYCIYLAGNSLHNMAYNNPIMDLDLNVRNFLNFMKHFRGQLILLSSQAVYYGLTGEIPENIIHYPTIPYGISKRFQEEYAKYFYKIGYLSKLWIFRLMYSFGKGERMDRLIPKCAKSAVNGDIVKVLGGGRSFLNPLPVNFVAEVLVNALLTMKEEDNEFLEVTNLNHSEKVSVLDIVKFLHTIKPFNYIVEEKGEIWPVSFWGSTEKLSRYLKKWNISFPNIWEDLEIYFKNLLTNMREKNYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ45</accession>
    <name>B8DZ45_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase C45 acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582756.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352285.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0360"/>
    <dbReference type="EnsemblBacteria" id="ACK41671">
        <property type="protein sequence ID" value="ACK41671"/>
        <property type="gene ID" value="Dtur_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0360"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_727110_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ45"/>
    <dbReference type="OMA" id="WDWMTEQ"/>
    <dbReference type="OrthoDB" id="1339204at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="380" mass="43737" checksum="B06B9EDFA7DEEF3C" modified="2009-03-03" version="1">MKRIFLLLLVLILISSQGCIKPEPVLKDTGIRIVELRGNPYEIGYQHGKELKEEIQYFSHRIEKLIIYKTILKTAKELAEEFGKTYPEFKELIEEMKGISNGAEVPYENILLFNLMDEIVLNYYWKISIIGCSAFVFRNKDGNLIIGRNLDYGVFVNELPLCPVIFKYYPEKGNPFISISFPGLVGAYTGISKNLYISINVSQSHKTNIGAPECLITRKIIQYSNSIDEALENALYPYQGLNLLIADDKKAVVLEISPRKKAIRALDKERFLVITNHFQHPEMISEQAEKLIEELPTPVDGTFVRQINTKEREKIIREMISSKEEIDVEYGKEILKNVSTRLTLQSIIYLPFQRKLFIAKNTTSPVSYGEWLEFNLKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ61</accession>
    <name>B8DZ61_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582772.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352301.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0383"/>
    <dbReference type="EnsemblBacteria" id="ACK41687">
        <property type="protein sequence ID" value="ACK41687"/>
        <property type="gene ID" value="Dtur_0383"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0383"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZ61"/>
    <dbReference type="OMA" id="AFMGAWD"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="65"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="268" mass="30444" checksum="3A97CAAFAFE77725" modified="2009-03-03" version="1">MSNKIIALLLIIGALIMFIPYWFMLVVSFETIEEASAVPPHLFPLNPIINNYKEIFIKLDFGRYFLNSLMVTLSLVFSQIILCSLAGYAFARLYFPLKNVIFLIFLSVIMLPGIVLLIPRYLILKNLSLVNTLIGVILLEIFSEFGIFLYRQHFLSMPIEMEEAAIVDGANMWDIFWKIMMPLSKPITLSFGLLVFIYGWNLFLWPLIVITSPEKRTLPIAIALLQGQYFSNWGVIMAGGVIASLPPIILFLFTQKSFVEGIAFSGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ64</accession>
    <name>B8DZ64_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582775.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352304.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0386"/>
    <dbReference type="EnsemblBacteria" id="ACK41690">
        <property type="protein sequence ID" value="ACK41690"/>
        <property type="gene ID" value="Dtur_0386"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0386"/>
    <dbReference type="eggNOG" id="ENOG503195F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120482_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ64"/>
    <dbReference type="OMA" id="MRLWSIH"/>
    <dbReference type="OrthoDB" id="1658214at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004260">
        <property type="entry name" value="Pyr-dimer_DNA_glycosylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03013">
        <property type="entry name" value="Pyr_excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="142" mass="17084" checksum="A76FA9147C8B766D" modified="2009-03-03" version="1">MRLWSIHPKYLDTKGLLAVWREGLLAKKVLEGRTKGYRNHPQLERFKKTEDPVLYINAYLFQIFLEAKRRGYNFDKKKIVEVEITDKIPVSKGQIYYEFQHLLKKLIIRDIKKYKEIKNTKKIEVHPIFKVIAGDIEPWERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ93</accession>
    <name>B8DZ93_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582911.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352440.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0536"/>
    <dbReference type="EnsemblBacteria" id="ACK41826">
        <property type="protein sequence ID" value="ACK41826"/>
        <property type="gene ID" value="Dtur_0536"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0536"/>
    <dbReference type="eggNOG" id="ENOG5033EUD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_860343_0_0_0"/>
    <dbReference type="OMA" id="HFYIDWP"/>
    <dbReference type="OrthoDB" id="1292538at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870980" evidence="1">
        <location>
            <begin position="24"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="351" mass="38086" checksum="9EB7E6126835BDE8" modified="2009-03-03" version="1">MKTKLILIFLLISLLLMSFSASAQQGLTLQDLLPESNKVPSWIKPGLVAVYKFQGGSGDQTSAGTGQGYQIYVITNIENNMAYGIGFDIFIAAGYPSYSSSIKPLKGVVYLDPKEVQDEVRKAQAAGFPQGMRQETGTAGNNLYYYLLESSDYQSMTRYFFVYDKNGLIQQVRILEKYGDGSSTVINVDLLGVYQTSLPSINTMPPAVKASPSYQLYSSVSLFGGTTSLSNPTPFGTTSYSLAKSTGSILTFSSQMNTSYGSKASKSYGNQYVGPFYIHPQLLKTNSILNIPQIGFSWTVAGRGQYGGILTQVQFSGSPIAQFEYDPNSGLLISCNFPTGGGMYFIAVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZC7</accession>
    <name>B8DZC7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582945.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352474.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0571"/>
    <dbReference type="EnsemblBacteria" id="ACK41860">
        <property type="protein sequence ID" value="ACK41860"/>
        <property type="gene ID" value="Dtur_0571"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0571"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013133_6_1_0"/>
    <dbReference type="InParanoid" id="B8DZC7"/>
    <dbReference type="OMA" id="GQIGMAF"/>
    <dbReference type="OrthoDB" id="791272at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015212">
        <property type="term" value="F:cytidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015213">
        <property type="term" value="F:uridine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071702">
        <property type="term" value="P:organic substance transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024989">
        <property type="entry name" value="MFS_assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12832">
        <property type="entry name" value="MFS_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="388" mass="43693" checksum="FF02E973B6705E8C" modified="2009-03-03" version="1">MKREIFLLKLFFFIYFSAWVFIFSFIPVYLREVKNFSIGMIGVLSAISSLSGALFQVYIGYLSDKFGKRKPFILIGFIVLILIYTFIFPSLKNFWSFLIVYFIVGIFTSTITTMANVLVMDYAVSERTGSHYASIRIWGSIGFLLVMLATGFYPKLVEHKVMFLMIGLIYLLGFILSIVIKESPVKTGISKVDFRSVKKIILKPEVRNFLIFYVIYFIALLGASSNVNLLIRSLGGESKHISFAYSASSFSEIPFMLIWGYLSDKLGRKPILIFTSIALPIRIFLYTLTNNPWHIILIQFMHSLTFAVIGTIPIVYMNDLVPPEERATAQGLLGMAMALSSTLGPAISGFVADLFGLPGMYRFLTFVSLISTVLAITSLKESKNRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZC8</accession>
    <name>B8DZC8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxiredoxin</fullName>
            <ecNumber evidence="7">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodecamer. Pentamer of dimers that assemble into a ring structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582946.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352475.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0572"/>
    <dbReference type="EnsemblBacteria" id="ACK41861">
        <property type="protein sequence ID" value="ACK41861"/>
        <property type="gene ID" value="Dtur_0572"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0572"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.608"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_4_0"/>
    <dbReference type="InParanoid" id="B8DZC8"/>
    <dbReference type="OMA" id="MIDYQDT"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="10"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7 8">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-219); in linked form" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="7">
        <location>
            <begin position="213"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-52); in linked form" evidence="7">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="225" mass="25562" checksum="0C0931BC11A25A7D" modified="2009-03-03" version="1">MENLERKGIPLLGEPFPEMKVKTTHGEKVLPNDYKGKWFVLFSHPADFTPVCTTEFVAFQKRYDKFRALNTELIGLSIDQVFSHIKWVEWIKEKLGVEIEFPIIADDTGKVAEKLGLIHPGKGTNTVRAVFVVDDKGIVRLILYYPQEVGRNIDEILRAVEALQVTDKYGVATPAQWPDSEVVGKDHVIIPPAGDVETVKARLEAAKKGEIECFDWWFCHKKLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZD0</accession>
    <name>B8DZD0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.14" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582948.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352477.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0574"/>
    <dbReference type="EnsemblBacteria" id="ACK41863">
        <property type="protein sequence ID" value="ACK41863"/>
        <property type="gene ID" value="Dtur_0574"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0574"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.610"/>
    <dbReference type="eggNOG" id="COG0381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZD0"/>
    <dbReference type="OMA" id="VYFVGDV"/>
    <dbReference type="OrthoDB" id="1117971at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="28"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="364" mass="41426" checksum="E6B339523E10F267" modified="2009-03-03" version="1">MGSFKVISIVGARPQFIKLAPFSIELRKSGIKEVILHTGQHYDENMSDLFFKELEIPEPDYNLGIGSSSHGEQTGRMLIGIEEVLIKEKPDVVIVYGDTNSTLAGALASSKLHIPLAHVEAGLRSFNKKMPEEINRIVADHLSDILFAPTETAVENLKREGIEKGVYLVGDIMFDALMHFSKLAKEKSKILEKLSLYPKGYYLVTIHRAENTDNPERLKSIFSALQELDKEVIFPIHPRTKNKVKEFGLEDYLKSRIRIIDPVGYLDMIQLEKNAYAILTDSGGVQKEAFWLKVPCITLREETEWVEIVKLKWNRLVGANKEKILEAVRNIKEGEDVNFEENYSAPKMREILVRELEKRGGEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZE2</accession>
    <name>B8DZE2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582960.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352489.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0587"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41875">
        <property type="protein sequence ID" value="ACK41875"/>
        <property type="gene ID" value="Dtur_0587"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0587"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_0"/>
    <dbReference type="InParanoid" id="B8DZE2"/>
    <dbReference type="OMA" id="RQAATWP"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="190"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="387" mass="44476" checksum="6C3B4926C5FC2501" modified="2009-03-03" version="1">MYNDIKILFLSKYLNPSGVTVFMFNLGKKLIENGYSVGIATGKETGEHSYSLKKFREAGFETFEIPFPGKGYGVSNILRLSKSILKYLEIIREYKPDLIHVHWRITSLFAELSYKLFGIPYIVTLHLEGIPNNRISKLLSFWGEYAIAISRETYDYLHSAFNLPLSKIKLIYNGVDEDYFYPPNENDRIDAKRKFGISLDDKVVCLIGRFSKVKGHDLLIKAASLLKERNVKPIFILAGSGDESWIRAMIEEYELQDQFISTGFLDSRDVLWASDILVLPSRKEGFPLVVVEAMLCGVPTIRTPAAGAYDQIEDGINGYIIPFEDEKSLADRIQLLIEDDELRRKISKKAFEKAKQVFTLREMVSNYIKVYEDVLSKKKKIYRYMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZE5</accession>
    <name>B8DZE5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352492.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0590"/>
    <dbReference type="EnsemblBacteria" id="ACK41878">
        <property type="protein sequence ID" value="ACK41878"/>
        <property type="gene ID" value="Dtur_0590"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0590"/>
    <dbReference type="HOGENOM" id="CLU_3288611_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="40" mass="4791" checksum="C8585191A8251B2D" modified="2009-03-03" version="1">MEYLDIKNRIERISKEITELRKRLILEGVIDKEKNEISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZE7</accession>
    <name>B8DZE7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582965.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352494.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0592"/>
    <dbReference type="EnsemblBacteria" id="ACK41880">
        <property type="protein sequence ID" value="ACK41880"/>
        <property type="gene ID" value="Dtur_0592"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0592"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2117126_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="114" mass="12826" checksum="722162A77AC64E25" modified="2009-03-03" version="1">MSLKILNANPNFSTLITLIFVYSVPIYDSALTVIRRFISGKSIFTPDLGHFYNKLYNITRNYVGTGLIIYLFSIVLGIIGIWLYSLTPILSLVLGGLIWIILVYLGYKLGFLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZF0</accession>
    <name>B8DZF0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582968.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352497.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0595"/>
    <dbReference type="EnsemblBacteria" id="ACK41883">
        <property type="protein sequence ID" value="ACK41883"/>
        <property type="gene ID" value="Dtur_0595"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0595"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.631"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080958_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZF0"/>
    <dbReference type="OMA" id="WGDLANK"/>
    <dbReference type="OrthoDB" id="1854408at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="206" mass="24437" checksum="D5229E6EDE7F2398" modified="2009-03-03" version="1">MAKLSDRVDRLESLLGQFIVNTDVALRRLETSLEVFKDEMKVFKEEMIAFRNEVNEDRKRINKMWGELANKMGTLVEDIVAPNITGIAKRYFGVEELDYFAVRVRKRNVKDRSKIREFDVIAVWDDKVIINETKSIPRIEYINEFIEVLKEIGDYFPEYKDKEIIPIFSSLYLSDEIVKYLTKRKIYAMATKDDTMDLLNFEKIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZG9</accession>
    <name>B8DZG9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0614</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582987.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352516.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0614"/>
    <dbReference type="EnsemblBacteria" id="ACK41902">
        <property type="protein sequence ID" value="ACK41902"/>
        <property type="gene ID" value="Dtur_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0614"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.651"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZG9"/>
    <dbReference type="OMA" id="KCEKLHG"/>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03367">
        <property type="entry name" value="queuosine_QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="125" mass="14684" checksum="6CBB3673F0D78E99" modified="2009-03-03" version="1">MFLIREFKFDAAHNLESYKGKCEKLHGHTYRLVIVVEGVPDSEGMIIDFVELKDIVKEEVINVLDHSYINEIMNQPTAENIAIWVWKRLEKKLQRDNCHLYEVQVWETEDSGVIYRGEKIEGCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZL0</accession>
    <name>B8DZL0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosidase PH1107-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 130 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583028.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352557.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0658"/>
    <dbReference type="EnsemblBacteria" id="ACK41943">
        <property type="protein sequence ID" value="ACK41943"/>
        <property type="gene ID" value="Dtur_0658"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0658"/>
    <dbReference type="eggNOG" id="COG2152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386731_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZL0"/>
    <dbReference type="OMA" id="KESYEMP"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007184">
        <property type="entry name" value="Mannoside_phosphorylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34106">
        <property type="entry name" value="PTHR34106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04041">
        <property type="entry name" value="Glyco_hydro_130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="714" mass="83285" checksum="2699421B3F96D262" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZP0</accession>
    <name>B8DZP0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583058.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352587.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41973">
        <property type="protein sequence ID" value="ACK41973"/>
        <property type="gene ID" value="Dtur_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0688"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_5_0"/>
    <dbReference type="InParanoid" id="B8DZP0"/>
    <dbReference type="OMA" id="DFVLLWN"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH crp-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="387" mass="43131" checksum="A8D5229C2FD3EAAD" modified="2009-03-03" version="1">MKIGRPQLIDEVNKGQILKLLREEGPISRAEIARRLGLSRPTVSTHIKELLKEGLVIEVGKGKGSKGRKGILLKYNARHGYFLAGDIEGSIMRFALSDLCGEILYEKVLSLNDLRQKNMMKPENFIDIIKQFLKENSVEEKNIRVIALGIAGIIEEGKLIFAPNLPEWNHAPLQNLIKEAFPETQVILENDVNTAVMGEMWKGAGKGLKNIVYLSLSTGIGAGIVIDGKLYEGSNKFAGEISYMVVDSHHENFPGVEYTPLGALEWVASGARIIEKAKSFDSKYTLLEIIFDDYNKVEEIKVLIDRIGEYLGKAIVNMVSVLDPEVIIVGGIVGKFLNILMRKIKPTIEYYLPVPVKIIPSALYPKTVVYGAIYRALELYHTKPVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZP6</accession>
    <name>B8DZP6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="4">PRAI</shortName>
            <ecNumber evidence="2 4">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">trpF</name>
        <name evidence="6" type="ordered locus">Dtur_0694</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="2 4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583064.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352593.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0694"/>
    <dbReference type="EnsemblBacteria" id="ACK41979">
        <property type="protein sequence ID" value="ACK41979"/>
        <property type="gene ID" value="Dtur_0694"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0694"/>
    <dbReference type="eggNOG" id="COG0135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZP6"/>
    <dbReference type="OMA" id="FYAKSPR"/>
    <dbReference type="OrthoDB" id="1854712at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PRAI" evidence="5">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="206" mass="23836" checksum="DD6CF935CC56A195" modified="2009-03-03" version="1">MWIKICGITDIISALHCEMEKVNAIGLVFVPWSPRFISMEQLKKMSPHLKRINIMKIGVFAGNSEEEIKEVLEILPLDGIQFHGNEDLSFLEKFKEYFLIRALNIDEEVDLEENIEKFSKLAYILLDKSKKSDMSFEEFIRKVKNYVDKKVIIAGGINESNVDMALELDPFGLDLSSGVEIEKGKKDLIKISNFMRKVRDYEKNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZR2</accession>
    <name>B8DZR2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583080.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352609.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0710"/>
    <dbReference type="EnsemblBacteria" id="ACK41995">
        <property type="protein sequence ID" value="ACK41995"/>
        <property type="gene ID" value="Dtur_0710"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0710"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.747"/>
    <dbReference type="eggNOG" id="COG3833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZR2"/>
    <dbReference type="OMA" id="LFWVYIA"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015423">
        <property type="term" value="F:ABC-type maltose transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042956">
        <property type="term" value="P:maltodextrin transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015768">
        <property type="term" value="P:maltose transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="68"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="281" mass="31126" checksum="1C0703487674C386" modified="2009-03-03" version="1">MKKNNFLNHIPKHLLIWIILVFTFFPVAWTVSASLRAGGGLVGQKLIPEVLTLEHYSNLKAIGFFNWIKNSLIVSLTTAILTVFFVSLAAYAFSRFNFWGKKYSLLTLLILQMFPAVMGMVAVYLLLFHIGKYIPFLGLNTLSGLIMVYLGGGVPYNIWLMKGFFDSIPDSLEESALIDGATRFQAYYKIILPLATPVLAVVAINSFIGTYSDFLLASIILKDPSKYTFAVGLRNFISGMYDVRWGDFAAASIVGALPIVILFLSLQNLIVSGLTRGAVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZU3</accession>
    <name>B8DZU3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583111.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352640.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0744"/>
    <dbReference type="EnsemblBacteria" id="ACK42026">
        <property type="protein sequence ID" value="ACK42026"/>
        <property type="gene ID" value="Dtur_0744"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0744"/>
    <dbReference type="HOGENOM" id="CLU_1419460_0_0_0"/>
    <dbReference type="OMA" id="YDFEWIL"/>
    <dbReference type="OrthoDB" id="2117880at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867599" evidence="1">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="192" mass="21953" checksum="C0BBE4662856288E" modified="2009-03-03" version="1">MKKNNILVMLLLLCFLLTLVFAQTQTPTKTQPPKRQATIFILHVLTFDSLSKTNLEKDLKALDDTFRMGIPIYHPAIGLNLSFYTKLHQKGLPYPSMINRILKNLVAPLSSSNLPEKTGINIVLYTQDDKDLYNGKTLFLNFALSAVKEYAKTKDLNKFGAQIIAFLETEKLEYKNGVFSSKNYDFEWILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZY7</accession>
    <name>B8DZY7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583155.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352684.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0789"/>
    <dbReference type="EnsemblBacteria" id="ACK42070">
        <property type="protein sequence ID" value="ACK42070"/>
        <property type="gene ID" value="Dtur_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0789"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.828"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_4_5_0"/>
    <dbReference type="InParanoid" id="B8DZY7"/>
    <dbReference type="OMA" id="YHIERNG"/>
    <dbReference type="OrthoDB" id="1971388at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004622">
        <property type="entry name" value="DNA_pol_HolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00678">
        <property type="entry name" value="holB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="25"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="326" mass="38173" checksum="F03CAC4DC38775AA" modified="2009-03-03" version="1">MAFKEIVGQRQAVEILRKAIHENRLSQTYLFVGPEGVGKKLTAISLVQALNCKIEPFEGCGKCDICEAIKNLSYPDLFYIEPEGQWYKIQQVRELRKEAYVKPYIGDLKVFILDEAHQLRNEGANALLKILEEPPEHTLFILIAYRPELLLPTIISRSQIINFTYLTYEEVWRIIEDKVPEDRLEVLVNLSQGSVGKAFFWNDENNWTKRVELFKYLTLLKKDKLYSPFDLVDFLAEEKDNEKIISLLELVLFWWRDLFFWKLTGDEKYITQKDFSVEIARKSQEYSISELKTFFRLTQDAIRGIRNNANLLLTLETLFLRVGLGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZZ9</accession>
    <name>RL31_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmE</name>
        <name type="ordered locus">Dtur_0801</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583166.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352696.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZZ9"/>
    <dbReference type="SMR" id="B8DZZ9"/>
    <dbReference type="STRING" id="515635.Dtur_0801"/>
    <dbReference type="EnsemblBacteria" id="ACK42082">
        <property type="protein sequence ID" value="ACK42082"/>
        <property type="gene ID" value="Dtur_0801"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0801"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.839"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_4_3_0"/>
    <dbReference type="InParanoid" id="B8DZZ9"/>
    <dbReference type="OMA" id="WYPDAKV"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000126610" description="50S ribosomal protein L31">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <sequence length="68" mass="7962" checksum="B9EB1052757F6E7C" modified="2009-03-03" version="1">MKKGIHPELKKAKIVCACGAVYETLSTKEYMTVEICSKCHPFFTGQRKFVDTEGRVERFTKKYNWEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E005</accession>
    <name>B8E005_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0807</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
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</entry>
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    <sequence length="207" mass="24918" checksum="64E919649516D0DC" modified="2009-03-03" version="1">MILKHKLIIFILFFLILINLAYLQDLNSLVEYYELKHRENPKDPDNIFNLLVLYGALGNLGKFYDYYNLLNKIDPNYLKEKAKENVKENTNNVFDLYKTAFSYYFLGEIEKSIYYFHKLNSLKPNDDWVISYLAYLYYLKEDYLKVESLINRGFEINEDNEALHALRCALYLKKGNYFLALKEYFITMNIVQRKGYKNIWEILRGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
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            <dbReference type="PubMed" id="28066333"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Fn3-like"/>
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        <property type="entry name" value="SSF52279"/>
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        <location>
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            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACK42133.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
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    <sequence length="762" mass="85354" checksum="A8706037C13C411D" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E058</accession>
    <name>B8E058_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0860</name>
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        <lineage>
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            <taxon>Dictyoglomales</taxon>
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    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352755.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0860"/>
    <dbReference type="EnsemblBacteria" id="ACK42141">
        <property type="protein sequence ID" value="ACK42141"/>
        <property type="gene ID" value="Dtur_0860"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0860"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.899"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="InParanoid" id="B8E058"/>
    <dbReference type="OMA" id="TDWFLVM"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="85"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="287" mass="31457" checksum="06A97FB22E2A3BF8" modified="2009-03-03" version="1">MMRTENFCQKPTRRMFKKFLRHKTGLLGSFLLFSFIFLAILAPIITPYDPYTQNLTERLLPPSSKHLFGTDYAGRDIFTRIIYGARISLIIGFISVFFALSFGVFLGLISGYFGGVWDVVIMRLIDIMLAFPTILLAIGIVAVLGPKLENTMIAVGIVSIPTFARVVRASVLSIKEKDFIAAAKAVGVSTGKILLKHILPNIVAPIIVQATLGIASAILEAAGLSFLGLGAKPPTPEWGAMLSESRQYLRSAPWTVVFPGLAIMLLVLAFNLFGDALRDVFDPKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E067</accession>
    <name>B8E067_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tilS</name>
        <name evidence="9" type="ordered locus">Dtur_0869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583234.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352764.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0869"/>
    <dbReference type="EnsemblBacteria" id="ACK42150">
        <property type="protein sequence ID" value="ACK42150"/>
        <property type="gene ID" value="Dtur_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0869"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.907"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_1_0"/>
    <dbReference type="InParanoid" id="B8E067"/>
    <dbReference type="OMA" id="QQYGMNA"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="376"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="36"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="455" mass="53285" checksum="3AB75E639784B8C6" modified="2009-03-03" version="1">MIKDINSLDYIEKKVLNFTRSESLISLGDSIILSVSGGSDSIALSEILYNLSPILGLKLHIVYIDHHVRKNTYKEKELIKDYATSRNIPYSFLDIYPKDFTEKTLRDERYKALIKFSEELNFNKIALGHTLDDQIETIIMNFFKGYGMEGLCGIPVKRDKFIRPIIILSKSEVIEYCERKSLKYIDDFTNLLPITLRNRIRHQIVPFLKETIQQFPQSVISQSKILYIENDFLKNISLEYFNKLKGSNTMIEIEREDWNTMHDAIKIRVLKEVFKDFNEELSNEGIFYILKEVSEIKEGKTINIGNVEIYIYNKKIYVYKKERNEFLLILPIPGKINLPTGEVIEAKLLENKKTEFNFNNLWQAYFDYDKIKAKELIVRNWKEGDKIKPFGLGGKSKKVQDVFVDKKIPRWKRTVVPLVLYKDEILWIPGIIRSDIAKITNDTKTILHLSLKKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E084</accession>
    <name>B8E084_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methylated-DNA/protein-cysteine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0886</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583251.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352781.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0886"/>
    <dbReference type="EnsemblBacteria" id="ACK42167">
        <property type="protein sequence ID" value="ACK42167"/>
        <property type="gene ID" value="Dtur_0886"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0886"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.924"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_0"/>
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    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="6">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="160" mass="18706" checksum="957B32710E369AAA" modified="2009-03-03" version="1">MKGALRVNNGFIMVEYEKSVIKRIYWTYKCEEEKDFPGKELFIDYFLGKKVDFGDLIIDLKRVPSIFKKIYEFTREIPYGKVISYKGIAEFLGNSKLQRVVGNAMKSNPFLIVVPCHRVVRSNGSIGNFSLGSEFKKYLLNLEGVKIENEKISCLRYWWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0A5</accession>
    <name>B8E0A5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OsmC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583632.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353164.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1272"/>
    <dbReference type="EnsemblBacteria" id="ACK42550">
        <property type="protein sequence ID" value="ACK42550"/>
        <property type="gene ID" value="Dtur_1272"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1272"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1312"/>
    <dbReference type="eggNOG" id="COG1765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114057_1_2_0"/>
    <dbReference type="InParanoid" id="B8E0A5"/>
    <dbReference type="OMA" id="GPRPMEM"/>
    <dbReference type="OrthoDB" id="1430018at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003718">
        <property type="entry name" value="OsmC/Ohr_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036102">
        <property type="entry name" value="OsmC/Ohrsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02566">
        <property type="entry name" value="OsmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82784">
        <property type="entry name" value="SSF82784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="136" mass="15281" checksum="04AF9F10006E7B53" modified="2009-03-03" version="1">METKVVWDGKMQFTGTTPSNFNIVMDAVPEHGGENKGPAPMELIPVALGGCTGMDVISILNKMKEKVEHFEMRITTERATEHPKVYTKVHIEYIFKGENLNEENIKKAIELSQNKYCSVSAILRGTAEVTYSYKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0D7</accession>
    <name>B8E0D7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="10" type="ordered locus">Dtur_1308</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583664.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353196.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1308"/>
    <dbReference type="EnsemblBacteria" id="ACK42582">
        <property type="protein sequence ID" value="ACK42582"/>
        <property type="gene ID" value="Dtur_1308"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1308"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1353"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_0"/>
    <dbReference type="InParanoid" id="B8E0D7"/>
    <dbReference type="OMA" id="IHAIIND"/>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="9">
        <location>
            <begin position="700"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="512"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="327"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="778" mass="89373" checksum="9A2FB72EDD6BB05F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0E4</accession>
    <name>B8E0E4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor SigA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">sigA</name>
        <name evidence="9" type="ordered locus">Dtur_1315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583671.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353203.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1315"/>
    <dbReference type="EnsemblBacteria" id="ACK42589">
        <property type="protein sequence ID" value="ACK42589"/>
        <property type="gene ID" value="Dtur_1315"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1315"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1360"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_3_0"/>
    <dbReference type="InParanoid" id="B8E0E4"/>
    <dbReference type="OMA" id="REISMMG"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="5">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="5">
        <location>
            <begin position="108"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="5">
        <location>
            <begin position="347"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="5">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="413" mass="48305" checksum="CE9EE61772EFB794" modified="2009-03-03" version="1">MPKKKIQKVTPEEVLAEFPYPEESIEEVEEFLESHELVDNEDLYVDVKEDKLPESVEEEVEIPEEIELDDPVKMYLKEIGKIPLLTPEEEIELAKRVEQGDEDAKKRLIEANLRLVVSVAKRYIGRGLSFLDLIQEGNLGLIKAVEKFDWRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVETMNKIHKITRLLTQSLGRKPTEEDIAKFLVIQQKLQEFEVYQESGEKISDDEIVEISMLSLDEIAKKLVELHLKTKGKKELTKEKINEEAKELRHVLEEEIKQQTEKVREISMMGQEPLSLEMPVGEDEDNRLADFVENKDLSPADIAVQKSLKKDIEELLNELSEREREILKLRFGLEDNQPRTLEEVGKLFNVTRERIRQIEAKALRRLRHPSRSKKIKDYLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0E5</accession>
    <name>B8E0E5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dnaG</name>
        <name evidence="16" type="ordered locus">Dtur_1316</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583672.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353204.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1316"/>
    <dbReference type="EnsemblBacteria" id="ACK42590">
        <property type="protein sequence ID" value="ACK42590"/>
        <property type="gene ID" value="Dtur_1316"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1316"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1361"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_3_0"/>
    <dbReference type="InParanoid" id="B8E0E5"/>
    <dbReference type="OMA" id="EINIFGY"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="15">
        <location>
            <begin position="252"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACK42590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="577" mass="66752" checksum="8ED422C278981387" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0F3</accession>
    <name>B8E0F3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Cytidine deaminase</fullName>
            <ecNumber evidence="6 11">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_1324</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 11">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 11">
            <text>2'-deoxycytidine + H(+) + H2O = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 11">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="6 11"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583680.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353212.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1324"/>
    <dbReference type="EnsemblBacteria" id="ACK42598">
        <property type="protein sequence ID" value="ACK42598"/>
        <property type="gene ID" value="Dtur_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1324"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1369"/>
    <dbReference type="eggNOG" id="COG0295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_4_1_0"/>
    <dbReference type="InParanoid" id="B8E0F3"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="OrthoDB" id="1895660at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047844">
        <property type="term" value="F:deoxycytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009972">
        <property type="term" value="P:cytidine deamination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="131" mass="14559" checksum="23ABBBA1E0753E3E" modified="2009-03-03" version="1">MDNKKLYELALKALENSYSPYSNFPVGVALLTKNGKVYLGTNIENASYGLTICAERVAIFKAVSEGEREFSKIVIVGKDGSGVPPCGACRQVMFEFSPDMEILLYDKEKGKFMTYRVKDILPLGFDLEANK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0F7</accession>
    <name>B8E0F7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybeY</name>
        <name evidence="8" type="ordered locus">Dtur_1328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583684.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353216.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1328"/>
    <dbReference type="EnsemblBacteria" id="ACK42602">
        <property type="protein sequence ID" value="ACK42602"/>
        <property type="gene ID" value="Dtur_1328"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1328"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1373"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_0_0"/>
    <dbReference type="InParanoid" id="B8E0F7"/>
    <dbReference type="OMA" id="RMRIHPL"/>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020549">
        <property type="entry name" value="YbeY_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01306">
        <property type="entry name" value="UPF0054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="142" mass="16564" checksum="1B4F864F70631DD7" modified="2009-03-03" version="1">MSVNIFDLYGCFDKKEEDRVKNFVKEVFKKEGFLPNKYDISVVLVDDEKIRELNSKYRGKDTPTDVLSFSLGKDPKGRIVGEIYISIDTAKIQAKENNKTLIDEVAFLTLHGLLHILGYDHENDEEYEKMEKETKKLISLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0I0</accession>
    <name>B8E0I0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ordered locus">Dtur_1351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583706.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353239.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1351"/>
    <dbReference type="EnsemblBacteria" id="ACK42625">
        <property type="protein sequence ID" value="ACK42625"/>
        <property type="gene ID" value="Dtur_1351"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1351"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1396"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0I0"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070930">
        <property type="term" value="P:trans-translation-dependent protein tagging"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="153" mass="17973" checksum="1C2744BF84CFC680" modified="2009-03-03" version="1">MAKEKKVVAVNRKARHDYSILETFEAGIVLTGTEVKSLRRGKVSLQDSYADVKNGEVWIYNLHISPYEHGNIYNHDPKRPRKLLLNKDEIAYLVGKVRERGLTLIPLSIYFNERGWAKVELGLAKGKKLYDKRRDIAERDERRELERLYKLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0I6</accession>
    <name>B8E0I6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/LC7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012548117.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353245.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1357"/>
    <dbReference type="EnsemblBacteria" id="ACK42631">
        <property type="protein sequence ID" value="ACK42631"/>
        <property type="gene ID" value="Dtur_1357"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1357"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128755_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0I6"/>
    <dbReference type="OMA" id="KEALWAP"/>
    <dbReference type="OrthoDB" id="1584836at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="PTHR13323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="20"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="160" mass="17974" checksum="2E5265CE8D2EEF98" modified="2009-03-03" version="1">MDEREQILSLVISLEDQEEIERYLGQFLAESKAKAALLIDKSGTVIGGRGTASQFDFVTISALAAGAFSATQELAKLLGEEEFSLIFHQGKRNHLHISHIEKQVLLLVIFDDSTTLGMVRLFAQKACENLAKIIKKIKEKQKDIPKAEFNFSDIEDFFKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0J0</accession>
    <name>RS18_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsR</name>
        <name type="ordered locus">Dtur_1361</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583715.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353249.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0J0"/>
    <dbReference type="SMR" id="B8E0J0"/>
    <dbReference type="STRING" id="515635.Dtur_1361"/>
    <dbReference type="EnsemblBacteria" id="ACK42635">
        <property type="protein sequence ID" value="ACK42635"/>
        <property type="gene ID" value="Dtur_1361"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1361"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1406"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_0_3_0"/>
    <dbReference type="InParanoid" id="B8E0J0"/>
    <dbReference type="OMA" id="QKKYCRF"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000125799" description="30S ribosomal protein S18">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <sequence length="84" mass="9908" checksum="4E8CDAC6EB7A30D1" modified="2009-03-03" version="1">MSNEKASTKAPKFAYPSKKKYCIFCSEKIDYIDYKNVERLKRFMTEKGKIIPRRISGNCARHQRQLSTAIKRARYMALLPYVVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0J2</accession>
    <name>RS6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsF</name>
        <name type="ordered locus">Dtur_1363</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583717.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353251.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0J2"/>
    <dbReference type="SMR" id="B8E0J2"/>
    <dbReference type="STRING" id="515635.Dtur_1363"/>
    <dbReference type="EnsemblBacteria" id="ACK42637">
        <property type="protein sequence ID" value="ACK42637"/>
        <property type="gene ID" value="Dtur_1363"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1363"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_5_1_0"/>
    <dbReference type="InParanoid" id="B8E0J2"/>
    <dbReference type="OMA" id="ITEASPM"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000120742" description="30S ribosomal protein S6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <sequence length="97" mass="11701" checksum="D0BCE30C4A99A449" modified="2009-03-03" version="1">MRKYEIMCLISPELSEEDFKTLYEGIQQDIQNLGGEVQNVDVWGKRTLAYPVKKFTEGYYVVMNFLFPQTQLPEFERRLKLREKLLRYMITLLEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0M2</accession>
    <name>B8E0M2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584117.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353656.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1770"/>
    <dbReference type="EnsemblBacteria" id="ACK43042">
        <property type="protein sequence ID" value="ACK43042"/>
        <property type="gene ID" value="Dtur_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1770"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0M2"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="393" mass="44442" checksum="A645EB45AD8FF09B" modified="2009-03-03" version="1">MKPRKIKEKVYYVGVPDWNRTLFDSLIPLPDGTSYNAYLVIGSEKTALIDTVDPTKKDILFSYFSNISKIDYVISHHAEQDHSGSIPFVLEKYPSAKVVTNPKGKELLKSHLHIPDDRFITVNDGEELSLGDKTLKFIYTPWVHWPETMVSYLMEDRILFTCDLFGSHYATSSLYVEDEKIVYEAAKRYYAEIMMPFRSIIQKNLEKIKELHIDLIAPSHGPIYNNPNFIINAYKDWISEDPKNIVVLPYVSMHDSTKIMVDYLADKLIEKGIAVEIFDLSTADIGKIAMALVDAATIIVGTPTVLAGPHPKALYVTYLANVLKPKAKFVSIIGSYGWGGRTLEILKNNLTNLNVEILNPVLVKGLPEKEDFKLLDELADAIYLKHKELGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0N5</accession>
    <name>B8E0N5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ordered locus">Dtur_1783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584129.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353669.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1783"/>
    <dbReference type="MEROPS" id="C26.952"/>
    <dbReference type="EnsemblBacteria" id="ACK43055">
        <property type="protein sequence ID" value="ACK43055"/>
        <property type="gene ID" value="Dtur_1783"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1783"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1835"/>
    <dbReference type="eggNOG" id="COG0505">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035901_2_1_0"/>
    <dbReference type="InParanoid" id="B8E0N5"/>
    <dbReference type="OMA" id="CFNTGMT"/>
    <dbReference type="OrthoDB" id="662268at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="358" mass="40824" checksum="99AE3E93691158C2" modified="2009-03-03" version="1">MKGKEAILVLETGHSFIGESFGYEGEVVGEIVFNTGMVGYPQTLTDPSYANQIIVFSYPLIGNYGVDTERLESSKIHCSGVVAREFNDYKFHWNSKKSLREFLIENKIVGIHKVDTRAIVREIRKFGTMKAIISTKEKDVFVLAKKLLKYDFNYLDLVRRVTTTVPYEVNPEGDKKLALLDFGVKMGILRELLKYNFRIKVFPAWTSFEDIKSYNPDGIVLSNGPGDPSNVPYVQETIRRIMALEKPVLGICLGIQLIALSLGAKTYKLKFGHRGANHPVYHVDSGRTYITSQNHSYAIDERTLPKGFEVNYYNLNDHTVEGIKHNFLPLVAVQFHPEASPGPWDTKFIFEEYYRLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0P6</accession>
    <name>B8E0P6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">5'-nucleotidase</fullName>
            <ecNumber evidence="4">3.1.3.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584140.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353680.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1794"/>
    <dbReference type="EnsemblBacteria" id="ACK43066">
        <property type="protein sequence ID" value="ACK43066"/>
        <property type="gene ID" value="Dtur_1794"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1794"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1846"/>
    <dbReference type="eggNOG" id="COG0737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005854_7_3_0"/>
    <dbReference type="InParanoid" id="B8E0P6"/>
    <dbReference type="OMA" id="VQPFTNM"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008768">
        <property type="term" value="F:UDP-sugar diphosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006146">
        <property type="entry name" value="5'-Nucleotdase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="PTHR11575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="SSF55816"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00785">
        <property type="entry name" value="5_NUCLEOTIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00786">
        <property type="entry name" value="5_NUCLEOTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="31"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="5_nucleotid_C" evidence="3">
        <location>
            <begin position="332"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="504" mass="56495" checksum="A7A8607D81C7F50F" modified="2009-03-03" version="1">MRHFKKFSLLLIVFFLFSSLIFAQELKPIEIKILHINDFHGRLQPYIVKSISETIPVGGGAYLSYLINEERSKNPDGTILLSAGDMFQGTPISNIFKGEPVIKMMNYLKFDAMTIGNHEFDWGQELLQTWIKNSNFPYLASNIIKNGDYLPNVKPYVILERKGLKIAIIGLTTPETAYIVKPDYVKDLTFLEPEKVLPNLIKEVKEKGAQLIVVLSHLGYDADKKLAENVQGIDVIVGGHSHTVVTKPTIVRGTIIVQAGYNGIYLGVLDLKIQPETGIILDFTRENELKTVFAAPENKYDTEVANLIETYNSQLKEEFSKVVGETLVDLVRNYNEESNVGNAICDAMLEASKAQIAFQNSGGIRIDIPKGKITMEQVYSLLPFDNVLVEMDLTGKDILDLLEQSATLEKGILQVAGIKVKYDMKRPIGSRVIEVFVNEEPLNPNKVYRVVTNDFLAAGGDKFIAFTRGKNITYGDMLRDVFVEYLKKHSPISPKVEGRSIVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0R4</accession>
    <name>B8E0R4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584158.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353698.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1813"/>
    <dbReference type="EnsemblBacteria" id="ACK43084">
        <property type="protein sequence ID" value="ACK43084"/>
        <property type="gene ID" value="Dtur_1813"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1813"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1865"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_0"/>
    <dbReference type="InParanoid" id="B8E0R4"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK43084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="303" mass="35001" checksum="5EC3A9BBFAA221E3" modified="2009-03-03" version="1">MEKQRYEIYVEGESERIDKYLSKKVPLSRSQIQDLIEKELIKVNEKPIKNSYKVKLGDRIEVIIPPPVETEVKPQDIPIEIVYEDEDMVIINKPKGMVVHPAHGHYNDTLVNALLYRVKDLSGIGGELRPGIIHRLDKDTTGLLIIAKNDLSHQKLSEQLKNRTLRRTYWALCEGEIPWEEKRIEAPIGRHPINRKKMAIVPYGKIAITNFKVLERFKGYTLISADLETGRTHQIRVHISHLGFPIVGDEVYGRIDKKFGVKGQLLHAKKVSFIHPTKGIPMEFEIDLPEEFKKVLTLLREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0S8</accession>
    <name>B8E0S8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583743.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353279.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1391"/>
    <dbReference type="EnsemblBacteria" id="ACK42665">
        <property type="protein sequence ID" value="ACK42665"/>
        <property type="gene ID" value="Dtur_1391"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1391"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1438"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0S8"/>
    <dbReference type="OMA" id="KQRFHLC"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="9">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1127" mass="128761" checksum="9EF74332D1EE20D8" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0W5</accession>
    <name>B8E0W5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative K(+)-stimulated pyrophosphate-energized sodium pump</fullName>
            <ecNumber evidence="9">7.2.3.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound sodium-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">Na(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hppA</name>
        <name evidence="10" type="ordered locus">Dtur_1428</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H2O + Na(+)(in) = H(+) + Na(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:57884"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Requires K(+) for maximal activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583780.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353316.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1428"/>
    <dbReference type="EnsemblBacteria" id="ACK42702">
        <property type="protein sequence ID" value="ACK42702"/>
        <property type="gene ID" value="Dtur_1428"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1428"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1475"/>
    <dbReference type="eggNOG" id="COG3808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008743_3_1_0"/>
    <dbReference type="InParanoid" id="B8E0W5"/>
    <dbReference type="OMA" id="MATTAMQ"/>
    <dbReference type="OrthoDB" id="98036at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="487"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium dependence" evidence="9">
        <location>
            <position position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="663" mass="69300" checksum="4FBB8C9717E095BA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0X2</accession>
    <name>B8E0X2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PASTA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583787.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353323.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1435"/>
    <dbReference type="EnsemblBacteria" id="ACK42709">
        <property type="protein sequence ID" value="ACK42709"/>
        <property type="gene ID" value="Dtur_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1435"/>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1445541_0_0_0"/>
    <dbReference type="OMA" id="WINMPQI"/>
    <dbReference type="OrthoDB" id="1531747at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="108"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="187" mass="21369" checksum="D509C791178D0B39" modified="2009-03-03" version="1">MRKWEIFKKISIRELILYLLIFVNFAVLVFLIFFLQKSINSNPNLVFPPDVRGKNLVEATDILAKNNFKVVIGGILIDKNKDPLMVLDQNPLNTKVPLGSIIFLWINMPQIVKIPDLIHKDTGEARNILEKLGLRVEIINGENGYIVRQIPESGFFIEKNATVILYSYTPQEPTYTSYTTEPYTGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E134</accession>
    <name>B8E134_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CBS domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1497</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583849.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353385.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1497"/>
    <dbReference type="EnsemblBacteria" id="ACK42771">
        <property type="protein sequence ID" value="ACK42771"/>
        <property type="gene ID" value="Dtur_1497"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1497"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1546"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_5_0_0"/>
    <dbReference type="InParanoid" id="B8E134"/>
    <dbReference type="OMA" id="ILCHTTA"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000007719">
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PolA_pol_head_dom"/>
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        <property type="entry name" value="PolyA_RNA-bd"/>
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    </dbReference>
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        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DHHA1"/>
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    </dbReference>
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        <property type="entry name" value="PolyA_pol"/>
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    </dbReference>
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        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF64182"/>
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    </dbReference>
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        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="317"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="379"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="845" mass="98133" checksum="31576A38624E9600" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E140</accession>
    <name>B8E140_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583855.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353391.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1503"/>
    <dbReference type="EnsemblBacteria" id="ACK42777">
        <property type="protein sequence ID" value="ACK42777"/>
        <property type="gene ID" value="Dtur_1503"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG1527">
        <property type="taxonomic scope" value="Bacteria"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_su_c/d_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_su_c/d_dom_3"/>
    </dbReference>
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        <property type="entry name" value="SSF103486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="285" mass="34295" checksum="822DBC3B0C63674A" modified="2009-03-03" version="1">MYTEYLFLSTNLKAKLPKLLDKRQWEVILSSDLGDIYSLLKETIYAPLLEGYSGFLKVLYEDLKVISNTVKYPYWDLMLFEFLTHDVRNEILQLEKEKMEISFNFLYGKTYKELKIKLSSKIQKISQQVSDVGWLNIIIDFGILEASKDLLKDVENTKVRDFVILKNKLNFMKIETRIEKTPYALEFLRKINLDLTSYKILYEDEELRQKFLEDSKIYDPDILIKKYLYSYMSKNFKNVVSGPEVVFYYFYAKMWEMEDLLFLLENKKMRIPKEYWERGLLRVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E190</accession>
    <name>B8E190_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583302.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352832.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0937"/>
    <dbReference type="EnsemblBacteria" id="ACK42218">
        <property type="protein sequence ID" value="ACK42218"/>
        <property type="gene ID" value="Dtur_0937"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0937"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.974"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_6_0_0"/>
    <dbReference type="InParanoid" id="B8E190"/>
    <dbReference type="OMA" id="CAHPLDF"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="142"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="214" mass="24198" checksum="6718D05DB28DE96C" modified="2009-03-03" version="1">MLVRMRMTKNPISVSPETSILEAWKIMQDSQVRRLLVMEKGKLVGIVTERDLRSVSPSQATSLSIFEINYLLEKLKVKDAMTPNPITVDADAPIEEAALIMRNNKISALPVIENDEVVGIITESDIFRAFIEMLGNGKKGLRYTLRIKNTPGEIAHIVSLIAKENINIMSMATFPAEDTEDYGYLVLRLETEDLTFVNEIFRKNNIPVVHIRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1A2</accession>
    <name>B8E1A2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GCN5-related N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583314.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352844.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0949"/>
    <dbReference type="EnsemblBacteria" id="ACK42230">
        <property type="protein sequence ID" value="ACK42230"/>
        <property type="gene ID" value="Dtur_0949"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0949"/>
    <dbReference type="eggNOG" id="COG1246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119519_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1A2"/>
    <dbReference type="OMA" id="IQEFWVA"/>
    <dbReference type="OrthoDB" id="1823496at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="PTHR30602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="149" mass="17272" checksum="9D3816E058C71A06" modified="2009-03-03" version="1">MIRKAKIEDIPEIHKIINEFAEKGLLLPRSLSDLYENIRDFYILVIDGKVVGTSALHIIWEDLGEVRSVIVKDEYRGRGYGKKLVDTCLREAKFLGLKRVLALTYIPEYFKKLGFVEVDKRTLPFKVWSDCVKCPKFPDCGEIALLYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1A4</accession>
    <name>B8E1A4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lgt</name>
        <name evidence="3" type="ordered locus">Dtur_0951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583316.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352846.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0951"/>
    <dbReference type="EnsemblBacteria" id="ACK42232">
        <property type="protein sequence ID" value="ACK42232"/>
        <property type="gene ID" value="Dtur_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0951"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.988"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1A4"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="276" mass="32028" checksum="2158594A7A57A33B" modified="2009-03-03" version="1">MYPKLLTIPQFQFLKYKIGPIVIYSWGTFVALGFLIGILLAMRWAKRENIDPDHVLNVAVWSIISSIIGARAVYVIKYWNAYKTNPITILHLWDGGLIFFGGFLVALVVVLLYLKRYKIDYWKFLDILAPAVAIGSAIGRIGCFLNGCCYGYETPLLWGVKFPNVYGYRHATELYYTIAFLIVFIYLLRVKSRKTFDGEVATNFFIYYSFAFFLVEIFRDNPRNFLYLTGSQTVSLLLIAFGIYAYRRRRAGRPIIPEQCLFWKIMTTKPKVSKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1H6</accession>
    <name>B8E1H6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, PadR-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352115.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0170"/>
    <dbReference type="EnsemblBacteria" id="ACK41501">
        <property type="protein sequence ID" value="ACK41501"/>
        <property type="gene ID" value="Dtur_0170"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0170"/>
    <dbReference type="eggNOG" id="COG1695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_5_1_0"/>
    <dbReference type="InParanoid" id="B8E1H6"/>
    <dbReference type="OMA" id="YRHLRQM"/>
    <dbReference type="OrthoDB" id="1706427at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="121" mass="14016" checksum="2D8B00B584B5E436" modified="2009-03-03" version="1">MKKCRTRITGLSPTFWLRAWIVISLSERELHGYELISSLSEIFPNLLSPGIGGMGRGYRILKDLEEEGIIVSRWDLEGTGPAKKVYRLTSEGERLREDIIKHIEEMQDYINKFLELSSKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1K1</accession>
    <name>B8E1K1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="4 8">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 8">
            <text>6-phospho-D-gluconate + NADP(+) = CO2 + D-ribulose 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 8">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="4 8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582611.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352140.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0197"/>
    <dbReference type="EnsemblBacteria" id="ACK41526">
        <property type="protein sequence ID" value="ACK41526"/>
        <property type="gene ID" value="Dtur_0197"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0197"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.203"/>
    <dbReference type="eggNOG" id="COG0362">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_4_2_0"/>
    <dbReference type="InParanoid" id="B8E1K1"/>
    <dbReference type="OMA" id="VIMVKAG"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046177">
        <property type="term" value="P:D-gluconate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="4 8" id="KW-0521">NADP</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="9">
        <location>
            <begin position="178"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="32"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="470" mass="53136" checksum="6E940AB280758762" modified="2009-03-03" version="1">MKNYIGLIGLAVMGQNLALNIARNGFSVSVYNRTPERTKEFIEKRVKEEKIDPYYDLKSFVESLEKPRKIILMVKAGQPVDEMIQELLPYLEPGDLIIDGGNSYFRDTSRRIRELKDKGILYLGMGVSGGEYGALHGPSLMPGGTKEAYKLVEEMLLKIAAKTEDGPCCTYVGDDSAGHFVKMVHNGIEYAIMELIAEIYDIMRKVLNMPSEEIGKVFESWNNGELNSFLMEISYKIMRVKDEETGKPLVELILDKAEQKGTGKWTAQTALDLGIPTPTLNMAVEARIISHFKDLRVELSKTLPVSKESISLNREEILKDLEKALLFGVFISFSQGLWLIDEASKVLNYNIDLSEVLRIWKGGCIIRAKILNFLREIIKENPQNANLLASEKTVNFLKDKIESVKKISDIGKRSGISLLCLNSALDYYFALATENLPANLIQAQRDFFGAHTYERIDKEGIFHTEWEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1R9</accession>
    <name>B8E1R9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582787.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352316.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0398"/>
    <dbReference type="EnsemblBacteria" id="ACK41702">
        <property type="protein sequence ID" value="ACK41702"/>
        <property type="gene ID" value="Dtur_0398"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0398"/>
    <dbReference type="eggNOG" id="COG1341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051301_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1R9"/>
    <dbReference type="OMA" id="IINTCGL"/>
    <dbReference type="OrthoDB" id="2018220at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="PTHR12755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="287" mass="32798" checksum="2877DF46E5E357A4" modified="2009-03-03" version="1">MIDIPPLWQETADAILLKKGVVIVIGLPNSGKSTFVKFLANYGVKNNSKVAIINSDLGQADIGVPGTISLSVIENELPSFENLSIKNWYFIGEITPVGKFLQVITGVRRLLDEAKEVAEIVIINTCGLVKGRLGKILKYYKTFVINPDHIVAIQSNTELDSLLKIIGRFSKYVYKIPKSVFARERSLEERREFREKRYEFYFQNAKNLIFPLYLVHSIDKYVDFQKENYRGRLVGLIGEKENLLELGIIQDVNLEKRHLLIFTPLKEITKVKRIEVGSIKLKVIKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1U1</accession>
    <name>B8E1U1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582809.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352338.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0421"/>
    <dbReference type="EnsemblBacteria" id="ACK41724">
        <property type="protein sequence ID" value="ACK41724"/>
        <property type="gene ID" value="Dtur_0421"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0421"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.445"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054732_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1U1"/>
    <dbReference type="OMA" id="LNFYNVH"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADH_N" evidence="1">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="423" mass="47481" checksum="A104A9E431D20B8D" modified="2009-03-03" version="1">METIALRMYGKMDLRLEKFELPEIKEDEILAEIISDTSCPSTYKEIVQGPDHPRVPKDVDKNPVIVGHEMAGVILKVGSKWKGKYEEGQKFTIQPALLYERGPVGVLSAPGYSYKYLGGLATKVVIPNEVMEQDCLLIYEGDAFYKASLIEPLSCVIGAVNAQYHTRENSYEHIMGIKRGGKTAILGGAGPMGLAFLAYLIYGPQNPSLLVITDIDDAKLQRAMKAFPKEEVNKKGIDIRFVNPTRDQSYKEIKYDDIFILYPSPKLVEEADSLLARDGCLNFFAGPTDHNFIACVNFYKVHYDKHHFVATSGGNADDMKIALDLIQRGVIDPSPMITHIGGLNVARDVLLNFPNISGGKKLIYTHIRFPLSEIEDFERLSVEGPEELKDIYRDLAQIVKDNNGWWCKEAEEYLLKRGEKIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1V4</accession>
    <name>B8E1V4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pectate lyase/Amb allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582822.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352351.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0435"/>
    <dbReference type="CAZy" id="PL1">
        <property type="family name" value="Polysaccharide Lyase Family 1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41737">
        <property type="protein sequence ID" value="ACK41737"/>
        <property type="gene ID" value="Dtur_0435"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0435"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.459"/>
    <dbReference type="eggNOG" id="COG3866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021894_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1V4"/>
    <dbReference type="OMA" id="NIGLYIN"/>
    <dbReference type="OrthoDB" id="660314at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PTHR31683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Amb_all" evidence="3">
        <location>
            <begin position="56"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="375" mass="41798" checksum="E17D5B19BA2E92FF" modified="2009-03-03" version="1">MRLKRYMSILVVGLFLLVISGCSPKIINVQPSIVIEGYDEPMIGFATIGDGTTGGAKGEVVVVKDYKEFFNAVYHSDDTPRIVLVDGTITYTISYYLEDPKYVNTINIASNKTIIGLGNGATIDGISLRIGRQGDPESNIIIRNITFDNAPDDNISIWWGSHHIWIDHCTFRRAVDSNVDITRQGNYVTLSWNIFEKFAGEGSKGVSIVGGSDTLPEDADYLRVTYHHNWFNGTAGRNPRMRYGIVHIFNNYYTDVQLGPNGTCAVRALVEHNYFERVLTPTQISTPPGFIVLSKEDPENGDTNVYVDSGTPTRNLPTYDQLTDGVNYDFRDRANEWLNISNWIPYSYTPDLAASVPQIVQEKAGAGKIIVNYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1V9</accession>
    <name>B8E1V9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582827.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352356.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0440"/>
    <dbReference type="CAZy" id="GH4">
        <property type="family name" value="Glycoside Hydrolase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41742">
        <property type="protein sequence ID" value="ACK41742"/>
        <property type="gene ID" value="Dtur_0440"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0440"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.465"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_0"/>
    <dbReference type="InParanoid" id="B8E1V9"/>
    <dbReference type="OMA" id="KYPMREK"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="203"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="460" mass="52989" checksum="1A01311AE73F747E" modified="2009-03-03" version="1">MNNVKIAYIGGGSKGWAWKFMADLALEESFSGEVRLYDINFEAAKTNEIIGNRISMQKDAKSKWRYRAVKEIGEALEGADFIIISILPGTFDEMEVDVHLPEKYGIYQAVGDTPGPGGVIRSLRTIPIYMEFAEAIKKYAPSAWVINYTNPMALCVRTLYVTFPKVKAIGCCHEVFKIPKILSLMLKEKEGIDVDPSEIKQNVLGINHFTWVDKISYKNKDLFPIYGEFAEKYYEEGFEEEKDRWKRDYFASANRVKFDLYRRYKLIAAAGDRHLAEFFPANWYLENPEKVRKWKFSLTPVSFRKEQAKELYEMSQKLAKGEMEFPIKPSGEVGVQIMKALLGLSDFITNVNYPNVGQMDGVPRDVIVETNVCITRDNIRPIYAGKLPNDVNSWVLRHIMNQEMILEAVLNKDLELAFRAFYNDPIVESKLDFDTARELFKEMIEGTKRYLPKYFGGEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1X3</accession>
    <name>B8E1X3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582841.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352370.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41756">
        <property type="protein sequence ID" value="ACK41756"/>
        <property type="gene ID" value="Dtur_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0455"/>
    <dbReference type="HOGENOM" id="CLU_1765108_0_0_0"/>
    <dbReference type="OMA" id="YAYGPRF"/>
    <dbReference type="OrthoDB" id="2130622at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="147" mass="15813" checksum="E77BDA5E41DE2B94" modified="2009-03-03" version="1">MKFKGFAVLSLVILGLLSLAYAYGPRFGGYLAQTNVQLTKISGTVSKILNTPALTITVKTASGDKEVILGPAWLQIKELKVGSKIEIEGFESPVSKNFKAVKVVVDGKEVLNLSKSVSYGNPGFGSPRGRRGFKNYQNCPCLSLQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1X7</accession>
    <name>B8E1X7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582845.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352374.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0459"/>
    <dbReference type="EnsemblBacteria" id="ACK41760">
        <property type="protein sequence ID" value="ACK41760"/>
        <property type="gene ID" value="Dtur_0459"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0459"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_1_0"/>
    <dbReference type="InParanoid" id="B8E1X7"/>
    <dbReference type="OMA" id="LEESHYN"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="131" mass="15416" checksum="C5B1C6F01DBF55E1" modified="2009-03-03" version="1">MERYERIFKVLSEEKRLKVFSLLLKMGEEYYVCEIADALEESHYNTSKYLNDLKKEGLVKEKRVGRGVLYSIKDPEDEFLKNIYKAVLSIPNELISRNMELLKLRVSLREENKCVIGVNDPRWSEIAKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E202</accession>
    <name>B8E202_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582870.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352399.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0487"/>
    <dbReference type="EnsemblBacteria" id="ACK41785">
        <property type="protein sequence ID" value="ACK41785"/>
        <property type="gene ID" value="Dtur_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0487"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_9_2_0"/>
    <dbReference type="InParanoid" id="B8E202"/>
    <dbReference type="OMA" id="NVAMFAY"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002867644" evidence="1">
        <location>
            <begin position="24"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="433" mass="48629" checksum="C31FD7C9C2C9DEF9" modified="2009-03-03" version="1">MRNKIGFLLISLILILSFVLAQATPYKTTINVLVWDDAHTKAVKSLIPEFEKVTGIKVNFVALPTRSVLEKAAVGISLDRTDYDLVAVDEPFVPQFGELLIPYTLWPKGRVFEKVDLKDIVEGAVNAAIWEGTPRGLPINGNVYVYIYRKDLFEDPKNKEEFKKEYGYELNPPNTFKELLDVSRFFSKKPNMYGFGPFTIKAEGVTAEAVFIMSSFGTDILKASGKTVRLVLDKKKAVEAIKFYKDLLETAPPGKLSFGHTERIQAFNMGQIAVMFQWPALIPNHEDPKQSLVAGKIGYIVPPAGPARRVAVTGCWILGIPKASKNKTAAAEFAYWWASKEAGKKLIEAGMSPVRKDLLSDPDLQKTRKWYQATLEAFKYGISRPRFKDYAKVSEVIQVYWTKGISGELTPEQAVDSMYNEIYKILKEGGYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E208</accession>
    <name>B8E208_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582876.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352405.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0498"/>
    <dbReference type="EnsemblBacteria" id="ACK41791">
        <property type="protein sequence ID" value="ACK41791"/>
        <property type="gene ID" value="Dtur_0498"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0498"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_0_0"/>
    <dbReference type="InParanoid" id="B8E208"/>
    <dbReference type="OMA" id="NIDYKAY"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="235" mass="25759" checksum="862044775685109F" modified="2009-03-03" version="1">MAGILTGRRMVITGASRGVGFEICKLFLKEGASIIGVGKDEKRLKEAEKFLKEIGDFEGVVADLEDENFTSKIVEKVEKKWNALDILFNNAGVMLSYGGFLEESDEIFEKTMGVNLYAPYKLVKALIPFLLKGKEPRIINTSSGAGTFDDIRKKYDIASYRLSKFALNGFTVILANELKDKVAVNAFDPGWVKTDLGGPNAPGLPEDSAKGALAVVTLPFEITGKFFKDGKEINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E210</accession>
    <name>B8E210_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582878.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352407.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0500"/>
    <dbReference type="EnsemblBacteria" id="ACK41793">
        <property type="protein sequence ID" value="ACK41793"/>
        <property type="gene ID" value="Dtur_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0500"/>
    <dbReference type="HOGENOM" id="CLU_1084748_0_0_0"/>
    <dbReference type="OMA" id="DSIWNFY"/>
    <dbReference type="OrthoDB" id="2122069at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="256" mass="29987" checksum="AD66F6372D787972" modified="2009-03-03" version="1">MSMSLERRISIFFLILFMVPFLIFLSIEGKLLKNESLYPLFYQIAEILSLIIAIYYFSKIGRVWRGWLGWLFVVLSLVLLFIADSIWNFYAIFKGEEAPFPGISDIFYMLFYVFAFVFLIYFIRLLRLEFDVSEKFLILLISLIFLVLLVQGILIPVLRSQEMTILSKILNIFYIVGDFILIILAFMLIVKLWGGKVAKNYSYFILAVSLTTIADILFVYIFRDYGISNWADIFYLASFLLLAYSIVRESLLHISK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2C7</accession>
    <name>HIS4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="1">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisA</name>
        <name type="ordered locus">Dtur_1125</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583487.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353018.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2C7"/>
    <dbReference type="SMR" id="B8E2C7"/>
    <dbReference type="STRING" id="515635.Dtur_1125"/>
    <dbReference type="EnsemblBacteria" id="ACK42404">
        <property type="protein sequence ID" value="ACK42404"/>
        <property type="gene ID" value="Dtur_1125"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1125"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1162"/>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2C7"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="OrthoDB" id="794219at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000135107" description="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <sequence length="242" mass="27949" checksum="8ED84FE79E388934" modified="2009-03-03" version="1">MLIIPAIDIYKSKVVRMETGKKEKIILEFDNPIDLAKYWEKKGAKALHLIDLQSAIDGIDENKNIIREIIKNVSIPVEVGGGYRDKEKIEEAINWGVWRVIVSSILEKDLGYLSDLFSKYKEKIIPSIDWYDGRVGIKGWQDFVEWRNIKDKLDLLRVKEVIFTDISRDGTLRGINVENIKTFLRLHDYDIWIAGGISSIEDIIKIKNIWKETERIKGVIIGRALLEGRINWEEAEDIINAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2D6</accession>
    <name>B8E2D6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1506</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583858.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353394.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1506"/>
    <dbReference type="EnsemblBacteria" id="ACK42780">
        <property type="protein sequence ID" value="ACK42780"/>
        <property type="gene ID" value="Dtur_1506"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1506"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1555"/>
    <dbReference type="eggNOG" id="COG1269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025558_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2D6"/>
    <dbReference type="OMA" id="MAVNIMA"/>
    <dbReference type="OrthoDB" id="259071at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016471">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="657" mass="76248" checksum="188B475BC815A46D" modified="2009-03-03" version="1"> </sequence>
</entry>
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    <accession>B8E2F0</accession>
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
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                <person name="Gowda K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="ACK42794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="310" mass="35900" checksum="9C39B3384E7BEC8A" modified="2009-03-03" version="1">MKIGVSSGSLEVLKRKIFKKDSPTTLYLLIGSKCLNNCAFCIQARNVRKETIMLSRISWPPIDLEELETLLSEFNPFKRICLQVTNHLGWKANIVKLTNAFKKYNLPISISAPVEDLEDVNFLFKNGVDRINISIDAAEKELYEKIKGKNWKEKIDLIREASKIFPKKITTHIIVGLGEKEKSLVELIKDLSCWEVKVALFAFTPLPGTPLENLSQPSYLKYRKIQIVTYLLQNHLIDSEDLTFDKDELILTKKILEKAYLYFHEIFKTSGCPYCNRPYYNESPRIIPYNYPRDLTKEEIEEIKLTLEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
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            <dbReference type="PubMed" id="28066333"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
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        <source>
            <dbReference type="Pfam" id="PF00703"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="577" mass="67849" checksum="976F22F10486047F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2I4</accession>
    <name>B8E2I4_DICTD</name>
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        <submittedName>
            <fullName evidence="1">SufBD protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353442.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1554"/>
    <dbReference type="EnsemblBacteria" id="ACK42828">
        <property type="protein sequence ID" value="ACK42828"/>
        <property type="gene ID" value="Dtur_1554"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1554"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1603"/>
    <dbReference type="eggNOG" id="COG0719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026231_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2I4"/>
    <dbReference type="OMA" id="SIQSYPT"/>
    <dbReference type="OrthoDB" id="635721at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="411" mass="46610" checksum="F54BF67F034DAEE5" modified="2009-03-03" version="1">MLKTYLKELRERALKAKNKPALLGPDIDLEPYMRTIRDVQVEDLDDLPDEIKENILYSGITPSEEERAGTYFQINHSVVYEKLKETYKGKLEIMSIQEALEKYDWLENYYGRLVSPDTDKYTAWAEILPTGGYFIRVFANQKVEYPVQSCLYIKEGNISQNVHNIIIVEENAEVFVTTGCLTHLKNQPGIHIGISEFFVKKGGKLYFTMIHNWSEEFHVRPRTVVLVEEGGLFINNYISLKPVKSIQSYPIIYVKENAIARLYSIIYGRKDSYIDLGGRIVFEGENSKGEIVSRIIADDSSQVYSRSELIGKAKGSKGFLDCRGIILNKNAKIVAIPILDAQHPESELSHEAAIGPINEEEIEYLTTRGFDKDEAMSTITRGFLNLEIPGLPKVAKEQISNTVAQLEKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2K3</accession>
    <name>B8E2K3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase FAD/NAD(P)-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583922.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353461.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1573"/>
    <dbReference type="EnsemblBacteria" id="ACK42847">
        <property type="protein sequence ID" value="ACK42847"/>
        <property type="gene ID" value="Dtur_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1573"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1621"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_2_0"/>
    <dbReference type="InParanoid" id="B8E2K3"/>
    <dbReference type="OMA" id="RYMKCGI"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="67"/>
            <end position="69"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="252" mass="28667" checksum="D9CFFCE040792E41" modified="2009-03-03" version="1">MVKDIVGEIVFNKKVGNNIYILSLEAEDVGEIYPGQFAMLRIENGYDPFLRRPMSLFKKNGNKYYFLYQVVGRGTEILSRKREGEEISILLPLGNSFPKLKERENVLIVGGGVGIAPLNFLVNFYKDQVNFYTFIGFSSFVLEEVYVDFKNYSREFVISSEDSSLGYKGKILDFIPENLDNFEKIISCGPSKMLEILMKKVKDKEKVYLSLEERMGCGFGICLSCAVRGKNRLLHVCKDGPVFCGTEVVFNE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-03-21" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2P6</accession>
    <name>NNR_DICTD</name>
    <protein>
        <recommendedName>
            <fullName>Bifunctional NAD(P)H-hydrate repair enzyme Nnr</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName>ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber>4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName>NAD(P)H-hydrate epimerase</fullName>
                <ecNumber>5.1.99.6</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName>NAD(P)HX epimerase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name type="primary">nnr</name>
        <name type="ordered locus">Dtur_1617</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136"/>
    <dbReference type="EC" id="5.1.99.6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583965.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353504.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2P6"/>
    <dbReference type="SMR" id="B8E2P6"/>
    <dbReference type="STRING" id="515635.Dtur_1617"/>
    <dbReference type="PRIDE" id="B8E2P6"/>
    <dbReference type="EnsemblBacteria" id="ACK42890">
        <property type="protein sequence ID" value="ACK42890"/>
        <property type="gene ID" value="Dtur_1617"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1617"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1666"/>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_0"/>
    <dbReference type="InParanoid" id="B8E2P6"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="OrthoDB" id="1748633at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000416417" description="Bifunctional NAD(P)H-hydrate repair enzyme Nnr">
        <location>
            <begin position="1"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal">
        <location>
            <begin position="9"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF C-terminal">
        <location>
            <begin position="226"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="NAD(P)H-hydrate epimerase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX 1; for epimerase activity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX 1; for epimerase activity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="ADP-dependent (S)-NAD(P)H-hydrate dehydratase" evidence="1">
        <location>
            <begin position="226"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX 2; for dehydratase activity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <label>1</label>
            <note>for epimerase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <label>2</label>
            <note>for dehydratase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="419"/>
            <end position="423"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <label>2</label>
            <note>for dehydratase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="514" mass="57287" checksum="77E4620963E45769" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Q2</accession>
    <name>B8E2Q2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NurA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583971.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353510.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1623"/>
    <dbReference type="EnsemblBacteria" id="ACK42896">
        <property type="protein sequence ID" value="ACK42896"/>
        <property type="gene ID" value="Dtur_1623"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1623"/>
    <dbReference type="eggNOG" id="COG1630">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625034_0_0_0"/>
    <dbReference type="OMA" id="YIRLMPR"/>
    <dbReference type="OrthoDB" id="2107229at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="54"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="369" mass="42553" checksum="F4CDB8AFF944A3CE" modified="2009-03-03" version="1">MPDFISLFISEIKKKKPLLEELLIKRGLNERPYIAEFIEKIWNNLSDTYDFTKKPTFAVDASQRTLSFSLGPYLIITQALAIGSNGYEKALVSIEPVVGSIPENQLGLLRDLLMQDLEIKLALQIVKENYPPFILLIDGSLLSRISYLLRYLHSFEDENYINLAYNVLMNTLDLINASKNGIDLISISKSSRNTFFFQILSIDNPDIEKNISYKPTDSEILSIFTWEPGYTTPLLIGAEMGLGHKQLEIIEKNSDLQKVLSNTQAFYTFYIRLMPRDQLLRIDFPANIVGEKANILSVNYFWGKDINMAQILGILKKNCVNSKIYQTPLYFVDQIVRIKREPDLERYLMILKKEFPGFIELDRSQGRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2R3</accession>
    <name>B8E2R3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1134</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SecG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012548001.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353027.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1134"/>
    <dbReference type="EnsemblBacteria" id="ACK42413">
        <property type="protein sequence ID" value="ACK42413"/>
        <property type="gene ID" value="Dtur_1134"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1134"/>
    <dbReference type="HOGENOM" id="CLU_094156_6_2_0"/>
    <dbReference type="OrthoDB" id="2172527at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="73" mass="8033" checksum="D149D8AC5249105C" modified="2009-03-03" version="1">MTIVLYILHFLVSIGMIAVILFQSEVGEGLGFIGGGETTFYKAKRQMEKGLKQATVVLAVLFMITSVLIFVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2R9</accession>
    <name>B8E2R9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recG</name>
        <name evidence="9" type="ordered locus">Dtur_1140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583501.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353033.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1140"/>
    <dbReference type="EnsemblBacteria" id="ACK42419">
        <property type="protein sequence ID" value="ACK42419"/>
        <property type="gene ID" value="Dtur_1140"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1140"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1177"/>
    <dbReference type="eggNOG" id="COG1200">
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        <property type="entry name" value="SSF52540"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="367"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="547"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="779" mass="89901" checksum="DE08501B98FBC646" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2S1</accession>
    <name>COAD_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="1">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaD</name>
        <name type="ordered locus">Dtur_1142</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583503.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353035.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2S1"/>
    <dbReference type="SMR" id="B8E2S1"/>
    <dbReference type="STRING" id="515635.Dtur_1142"/>
    <dbReference type="EnsemblBacteria" id="ACK42421">
        <property type="protein sequence ID" value="ACK42421"/>
        <property type="gene ID" value="Dtur_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1142"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1179"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2S1"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000118075" description="Phosphopantetheine adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <sequence length="160" mass="18295" checksum="5897336C1FEA7B47" modified="2009-03-03" version="1">MIKAVYPGSFDPVTNGHIDIIQRGAKIYDEVIVLVAENISKTPLFSLEERLDMLRHSLKDIPNVKIDHFSGLLVDYLKKIDVKIIIRGLRAVSDFEYEFQQALTNKKLYPECETVFLVSDLKYTFLSSSMVKEIAKFGGCIKGLVPDYVAEKLYEKFKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2T5</accession>
    <name>B8E2T5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid/glycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583517.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353049.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1156"/>
    <dbReference type="EnsemblBacteria" id="ACK42435">
        <property type="protein sequence ID" value="ACK42435"/>
        <property type="gene ID" value="Dtur_1156"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1156"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_5_0"/>
    <dbReference type="InParanoid" id="B8E2T5"/>
    <dbReference type="OMA" id="RPWVEGL"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="46"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="220" mass="24941" checksum="BA3B1FC89B593880" modified="2009-03-03" version="1">MKRRKYSTKFQFFVYKSIAGVIKVLLKRIYKLEINGLENVPLEGPVIIAPNHRSSLDVLAIAVSLPRPIKALGKVERFKYPLLGRFAQYLGGIPVERGHADLSAVKGGIEVLKRGEILLIFPEGTRLRLEKKDIKPKRGIGYFAAKMKVPVVPTAIIGADCIWPPEKKLPALKGRIKVIFLQPVYYEGEPDRIKEEEFTNKIMSQIEEVLRRESLNHEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2X0</accession>
    <name>B8E2X0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="6">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-IPM isomerase</fullName>
            <shortName evidence="6">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">leuC</name>
        <name evidence="8" type="ordered locus">Dtur_1191</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583552.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353084.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1191"/>
    <dbReference type="EnsemblBacteria" id="ACK42470">
        <property type="protein sequence ID" value="ACK42470"/>
        <property type="gene ID" value="Dtur_1191"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1191"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1228"/>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_0"/>
    <dbReference type="InParanoid" id="B8E2X0"/>
    <dbReference type="OMA" id="GIEHCLL"/>
    <dbReference type="OrthoDB" id="749418at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011823">
        <property type="entry name" value="IsopropMal_deHydtase_lsu_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02083">
        <property type="entry name" value="LEU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="5 6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="7">
        <location>
            <begin position="7"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="424" mass="46576" checksum="BD734CF1225E5754" modified="2009-03-03" version="1">MGMTITEKILADHSSKKEVFPGELIFVKLDFLLANDITGPLAIKEFEKIGVEKVFDNEKIALVPDHSTPNKDIKSAMQSKILREFAKKQGIKYYYEVGRVGIEHALLPEEGLVLPGDAIIGADSHTCTYGALGAFSTGVGSTDLAYAMATGEIWLKVPESIKFVYYGKLSQWVTGKDLILYTIGQIGVDGARYKAMEFTGEVIRNLSMSDRLTICNMAIEAGAKNGIIEPDEITLEYVRNRAKRNFKVYKSDEDAHYKEIYEWDVTNLEPIVAFPHLPSNIKKISDIGKDIYIDQVYIGSCTNGRIEDLRLAAKILKGHKVHKDVRLIVTPATPNVYMQALKEGLIEIFLEVGASITPPSCGPCLGGHLGVLAEGEKAVATTNRNFVGRMGHPKSEVYLSNPAVAAASAILGRIAAPWEVEVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2X2</accession>
    <name>B8E2X2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="13">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="13">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">leuB</name>
        <name evidence="16" type="ordered locus">Dtur_1193</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 13 14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 13 14">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="13"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583554.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353086.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1193"/>
    <dbReference type="EnsemblBacteria" id="ACK42472">
        <property type="protein sequence ID" value="ACK42472"/>
        <property type="gene ID" value="Dtur_1193"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1193"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1230"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_0"/>
    <dbReference type="InParanoid" id="B8E2X2"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 13 14" id="KW-0520">NAD</keyword>
    <keyword evidence="10 13 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iso_dh" evidence="15">
        <location>
            <begin position="4"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACK42472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="363" mass="40290" checksum="342B26F5B9FE79E8" modified="2009-03-03" version="1">MRVKIAVLPGDGIGPEVVKQAIKVINVLSKKFHHQVEIKEGIVGGAAIDKFGDPLPEETWKICEESDSILLGAVGGPKWDNLPGDKRPEKALLKLRSGFNLFANLRPISIFDELIFSSPIKEEYLKGVDFIIVRELTGGLYFGKPKETRIENGEEIAIDTMIYRTSEIRRIAHVAFKMAQKRKKKVTSVDKANILECSRLWRKIVEEVAKEYPDVALEHMYVDNCAMQIVRNPKQFDVILTENTFGDILSDEAAVITGSIGMLPSASLGETKKGLYEPIHGSAPDIAGQNVANPIATILSVALMFRYSFDLEEEAKLIEKSVRKVLSLGYFTKDLYANNPYAQKMVTTEEMGDLICSVIEGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Z6</accession>
    <name>B8E2Z6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583578.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353110.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1217"/>
    <dbReference type="EnsemblBacteria" id="ACK42496">
        <property type="protein sequence ID" value="ACK42496"/>
        <property type="gene ID" value="Dtur_1217"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1217"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_0"/>
    <dbReference type="InParanoid" id="B8E2Z6"/>
    <dbReference type="OMA" id="LWSKVAQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="178"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="200"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="371" mass="41649" checksum="4137E07BA2C085A3" modified="2009-03-03" version="1">MKRKLKYFENKIKDLSLLLNISSKINSKLDIHELLDLIMSLVKENLNVEACSLLLLDRNKEELYFEVALGEKGEEIKRYSIKVGEGIAGKVAETGIPIIENRVETNPLFNPKFDFLTSFKTKALICVPLVHQGEIIGVMEVINKKDNKKFTKSDLKLLQAISNQASIAIKNALLYQDLKTLFFDTIESLVSAIDAKDPYTHGHSKRVSEIAILIAKEIDNSTDFIEKVRLSGLLHDIGKIGIEESILTKKGKLTLEEIEIIKKHPTIGKKILEPIDLLREILPGVEEHHEKYDGSGYPKGLKGENISLLGRIISVADVFDALTSDRPYRKGLDVHSALLEINSLSGVHFDPYIVNILNSLYQRGKLFCFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E300</accession>
    <name>B8E300_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583582.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353114.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1221"/>
    <dbReference type="EnsemblBacteria" id="ACK42500">
        <property type="protein sequence ID" value="ACK42500"/>
        <property type="gene ID" value="Dtur_1221"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1221"/>
    <dbReference type="eggNOG" id="COG4684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164415_0_0_0"/>
    <dbReference type="OMA" id="SIMYGPR"/>
    <dbReference type="OrthoDB" id="1466380at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024529">
        <property type="entry name" value="ECF_trnsprt_substrate-spec"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12822">
        <property type="entry name" value="ECF_trnsprt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="239" mass="25940" checksum="FAB6E84B194603DA" modified="2009-03-03" version="1">MKSKKIALSAIFLALTLIMGLTRIGYITVPTPAGAATLMHIPVILSGVLLGPWIGALAGLMFGFSAVLYFSYIAPFWVLLPARPFIGIIAGLVYSFFMRYTNSQKRIKNYALIIISIVVFSFLYLSGIFILNEWFSSSLVLYPIEYSFLIALIAFLVSILITFLIKEKETKIVGLGVASFLGSITNTIGTLGLAAIAKIFPIQVIITIGIVQGIPEAILATIICPPIVLAIERFLKGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E301</accession>
    <name>B8E301_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583583.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353115.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1222"/>
    <dbReference type="EnsemblBacteria" id="ACK42501">
        <property type="protein sequence ID" value="ACK42501"/>
        <property type="gene ID" value="Dtur_1222"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1222"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1261"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_2_2_0"/>
    <dbReference type="InParanoid" id="B8E301"/>
    <dbReference type="OMA" id="ASDYWRE"/>
    <dbReference type="OrthoDB" id="1816478at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="5"/>
            <end position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="127"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="182" mass="21670" checksum="6E404417EC1EAA94" modified="2009-03-03" version="1">MNLDKKMLRIELREKRKKIENKEERSHQIFHNLERLLIWKEAKIINTYVSLEEEVDTKFIIYHGLIERKRIFCPIIYKEELKFGEIFSFNDLKKGTFGILQPEIPTEIDVFDLIIVPGIAFDKKGYRLGYGKGYYDKFLSRTKKGIKIGLIFDDLLLEELPHEDHDQKVDIIITENKVIEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E341</accession>
    <name>B8E341_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Monosaccharide-transporting ATPase</fullName>
            <ecNumber evidence="7">3.6.3.17</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.6.3.17" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583990.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353529.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1642"/>
    <dbReference type="EnsemblBacteria" id="ACK42915">
        <property type="protein sequence ID" value="ACK42915"/>
        <property type="gene ID" value="Dtur_1642"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1642"/>
    <dbReference type="eggNOG" id="COG1172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028880_4_1_0"/>
    <dbReference type="InParanoid" id="B8E341"/>
    <dbReference type="OMA" id="VFTTITN"/>
    <dbReference type="OrthoDB" id="1254678at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="317" mass="34003" checksum="A8641334E5934B30" modified="2009-03-03" version="1">MKIKSNKQNLRFYFRELNILLALAVLCVFITIMNPKFITPFNLQVVARQIAIYGLLAIGETLIIIGGGIDLSVGSLVALTGVLVALFMKNGIDMVVAILLVLIISCLIGFWHGFFVTKLNVPPFIITLGTLTAARGLASVITKGWPIIGLPEKFFFIGQGDLWGIPFPTVILIVFAILAFFITKYTVLGRDLYAVGGNIEAARLSGIDVDKVRMFTYVFGSFLAGITGIIIASRLSQGQAGVGGGYELSAIAAAVIGGTSLSGGEGTILGTIIGASIMSVIYNGLILLEISSYWHDVVMGLVIVTAVTIDIWRKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E355</accession>
    <name>B8E355_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiazole synthase</fullName>
            <ecNumber evidence="4">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1657</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584004.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353543.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1657"/>
    <dbReference type="EnsemblBacteria" id="ACK42929">
        <property type="protein sequence ID" value="ACK42929"/>
        <property type="gene ID" value="Dtur_1657"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1657"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1707"/>
    <dbReference type="eggNOG" id="COG2022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062233_1_0_0"/>
    <dbReference type="InParanoid" id="B8E355"/>
    <dbReference type="OMA" id="PHNFQLI"/>
    <dbReference type="OrthoDB" id="784095at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0784">Thiamine biosynthesis</keyword>
    <feature type="domain" description="ThiG" evidence="6">
        <location>
            <begin position="6"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="257" mass="27912" checksum="A09DBF7F988483B5" modified="2009-03-03" version="1">MGLIIDNTIINNRLFVGTGKLPDYSVIPKMHEELKIEVFAVAVRRINPEINKGYSILDFLPKTAKIMINTSGARNHKEAVKIAEIGRELTGSDWVKIEISGELKYLLPDNEETIKAAEILVKDGFKVFPYISPDLIVAKKLEEIGVSAVMPLGSPIGSNKGIDCETLLKAIINEISIPVIIDAGIGRPSHASKAMELGADAVLINTAIATSNDPFKMAEAFNLAVKAGRIAYEIGLPEEKDYADASSPLIDFIKGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E357</accession>
    <name>B8E357_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine biosynthesis protein ThiF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584006.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353545.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1659"/>
    <dbReference type="EnsemblBacteria" id="ACK42931">
        <property type="protein sequence ID" value="ACK42931"/>
        <property type="gene ID" value="Dtur_1659"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1659"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_4_0"/>
    <dbReference type="InParanoid" id="B8E357"/>
    <dbReference type="OMA" id="NGLMAPR"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061503">
        <property type="term" value="F:tRNA threonylcarbamoyladenosine dehydratase"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061504">
        <property type="term" value="P:cyclic threonylcarbamoyladenosine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012729">
        <property type="entry name" value="ThiF_fam2"/>
    </dbReference>
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        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
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        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02354">
        <property type="entry name" value="thiF_fam2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="9"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="200" mass="22643" checksum="DBD470BFAF3B95C1" modified="2009-03-03" version="1">MNSFEEMLLNYFTKEQLDKIQKTRIVIMGCGGLGSNGAISLTRTGFKNFILIDYDKVEISNLNRQAYFLHQIGMPKVKALKENLLKINPDCNIEEYEEKITPENIEIFMNKGDIIMEAVDSAQTKTLILNTAIKLNKKIVSASGVCGYGNSEKIKIKRFNNISIVGDFESDNSLFKPYAPKVIAISNIQCDEILRMVLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E359</accession>
    <name>B8E359_DICTD</name>
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        <submittedName>
            <fullName evidence="9">Thiamine biosynthesis protein ThiC</fullName>
        </submittedName>
    </protein>
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        <name evidence="9" type="ordered locus">Dtur_1661</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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            <name>[4Fe-4S] cluster</name>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1661"/>
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        <property type="gene ID" value="Dtur_1661"/>
    </dbReference>
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    <dbReference type="PATRIC" id="fig|515635.4.peg.1711"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_2_0"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="417" mass="47178" checksum="3620C238B09E1D6F" modified="2009-03-03" version="1">MENTLLEKAQKGELSYEIKSAFENEEIPAMEILLKNIVEGKTVIPANKKRKRNKYYAIGKDCTVKINANIGVTGSYSSFDKELKKAELCEKYNVESVMDLSCGTFAKRFREKLINEFSFIVGSVPIYDLSVKFKDFTKAKPKDFLEVLEEHVETGVDFVTIHAGINRELVEKLKDKNRLLNIVSRGGSMIYKWMETNNFENPYFEYFEDVLKILKKYDATISIGDAFRPGCIQDAGEELQVRETYIVSKLAEKAREYGVQVIIEGPGHVRANEIYWTVKMIKKICKDAPLYVLGPLTTDIAAGYDHISGSMGALIASLAGADFLCYVTPAEHLRLPDLEDVKEGIIAFKIAAHSANIARGFRKSIEKDIEMSLARRELNWEKIINLSIDPEKTKRYRGELHNTCTMCGELCAIKNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E398</accession>
    <name>B8E398_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584047.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353586.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1700"/>
    <dbReference type="EnsemblBacteria" id="ACK42972">
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        <property type="gene ID" value="Dtur_1700"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1700"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705422_0_0_0"/>
    <dbReference type="InParanoid" id="B8E398"/>
    <dbReference type="OMA" id="IGIAMPW"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="210"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="391" mass="44185" checksum="83E30043CEDC0CCE" modified="2009-03-03" version="1">MKSNRVNFLTKILVLLSVGGVGLSFFQAFRGFSLIFFINKFVNSKSQIGVLLSLGSLVGIFVPPLVGFLSDKLKKLIKGRKYLIIVSLFFLSLSIYFLEKTKNLSELYLYLTLTYIFFYSAISLYQALVPDLFSKDFFARATGVLNFASQFFQGIYIFIIVISHASNLTFTLLKWSIFLSSFLFFFIPEKENKRISQNFSMDMKFLRRKFWFNLFLLQFFVWYGISSVSSFILLFFQDVLSASLSDYMIILVIFGVLTALSTFFSGFVADKFAKEKLSAMSLALFGISSFLFSQTQRINMAFISSVFYGISLGFLTVIPYSLILSYIPKDKEGSIVGINALVVSVSQVIAYLTSGVMIDILGYRANFLQGLIATILGLLVLRNVTNNKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E399</accession>
    <name>B8E399_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584048.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353587.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1701"/>
    <dbReference type="EnsemblBacteria" id="ACK42973">
        <property type="protein sequence ID" value="ACK42973"/>
        <property type="gene ID" value="Dtur_1701"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1701"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_587584_0_0_0"/>
    <dbReference type="OMA" id="WDRFISE"/>
    <dbReference type="OrthoDB" id="1143375at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="468" mass="55532" checksum="9311677C7BABAA71" modified="2009-03-03" version="1">MSLNGDLKSVSLWEVLEILSFSRKTGRLQLTKDKKKTDVYFEDGKIKHIKADTCEDEDAILHLALWKEGNFAFYPDEKAPKANLNLDPLHILVDVSKDIDLIEYLGDLVFLFVNVANLSDEERQVGNLFDGIRTTKDIILNSPYGEYRTLRIIEKLRRNKNLLRIDDNINLFWTYTFWRYFIFTLERENERDFRKKWSDQLNKLTTYKLAFEILTKDRKVEWYNVYPLIKDAPSNEYFNVIKNVFFFIENYRKLEINNVIDTGKILFLSQELDPFMSKIYVPIKYSEVIEENIVLWSLDGKRTFKDVENILPFGDLRRLQLIKSVLDKKLVLPLGYNIKLDLLNYFFMAWQEMLAKFEKIGKREEFVKEWDRFISESLSDVKHLFSYLPSESKQNFPYFYRNIANSQEEELRAFLKEALKLIIDFASKTLPKEEVDNLINKIMDHAKTYASDKLIEAAQRILSEVYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3B3</accession>
    <name>B8E3B3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-xylanase</fullName>
            <ecNumber evidence="6">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584062.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353601.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1715"/>
    <dbReference type="CAZy" id="CBM22">
        <property type="family name" value="Carbohydrate-Binding Module Family 22"/>
    </dbReference>
    <dbReference type="CAZy" id="CBM9">
        <property type="family name" value="Carbohydrate-Binding Module Family 9"/>
    </dbReference>
    <dbReference type="CAZy" id="GH10">
        <property type="family name" value="Glycoside Hydrolase Family 10"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42987">
        <property type="protein sequence ID" value="ACK42987"/>
        <property type="gene ID" value="Dtur_1715"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1715"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1766"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001408_1_0_0"/>
    <dbReference type="InParanoid" id="B8E3B3"/>
    <dbReference type="OMA" id="TYAFEAW"/>
    <dbReference type="OrthoDB" id="654705at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="PTHR31490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="341"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1037" mass="118689" checksum="F6290678A372F129" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3C3</accession>
    <name>B8E3C3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1725</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584072.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353611.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1725"/>
    <dbReference type="EnsemblBacteria" id="ACK42997">
        <property type="protein sequence ID" value="ACK42997"/>
        <property type="gene ID" value="Dtur_1725"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1725"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044700_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3C3"/>
    <dbReference type="OMA" id="YADKLWY"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="106"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="462" mass="53418" checksum="F0E589D12B7F598D" modified="2009-03-03" version="1">MSTQSLKFKMYLGDMLFESLFKYVAKDYKKRIPKLLNLVKRFSPDEGTDKIISTIEEYLQKDPAVQRLIHRVFTDYDPNYASRIFANVILNVGFFWIYFNNENQKKDIPTPYTILISPTMRCNLQCIGCYAGNYTKNDDLPPETVERIIKEGEEIGTYFYTVLGGEPFVYPGLLDIVNRHPRSVFQIFTNATLLDENKIERFWKSKNVVPVLSLEGGKEETDYRRGLGVYEKVVNAMDLLKKAGIPFGYSITLTRNNFEAVTKPEFYQWLANKGAFFGWTFLYMPVGKDDDPSLMPTPEQRAEYGKFIRKIRGHLPIYPMDFWNDAPYVGGCIAGGRRYLHINHKGEVEPCIFAHFAVDNIKEKSLVEVLNSEFFKEIRKRQPFHENLLLPCMIIDSPWILREIVQKTGAHPTHPGADDIITKFAPIIDEYAKGVRKALNPIWVEEFHGDLPEEEKEKVGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3D4</accession>
    <name>B8E3D4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, LacI family</fullName>
            <ecNumber evidence="5">5.1.1.1</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1736</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584083.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353622.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1736"/>
    <dbReference type="EnsemblBacteria" id="ACK43008">
        <property type="protein sequence ID" value="ACK43008"/>
        <property type="gene ID" value="Dtur_1736"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1736"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_6_1_0"/>
    <dbReference type="InParanoid" id="B8E3D4"/>
    <dbReference type="OMA" id="ADPFYGP"/>
    <dbReference type="OrthoDB" id="1796334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01392">
        <property type="entry name" value="HTH_LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000843">
        <property type="entry name" value="HTH_LacI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00356">
        <property type="entry name" value="LacI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00036">
        <property type="entry name" value="HTHLACI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00354">
        <property type="entry name" value="HTH_LACI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53822"/>
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    </dbReference>
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        <property type="entry name" value="HTH_LACI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH lacI-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK43008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="333" mass="37357" checksum="089A9BE61EC89CF4" modified="2009-03-03" version="1">MVVERKSHITIKDVAKLAGVGIATASRALNNRGDVHPETRRKVLEAAQKLGYVPNSLARSLVYGKTKKVGVIITTVLNPFYAAVVSGIERVLTANGYTLILYNSNEDPRKEREALLILRQQRVDGIIFAPIEYESQNVKYLIDSKIPFVLVARRTLEEDTSFVIADDFKVGKIGTEHLIEKGHRRILFLNSWKNSSAKFRLEGYKSALREAGFLINPKLIYSIKPDTDLKKLISEIFSSKSRPTAIFCFCDSIALEVMKVVKEEGLKIPDDVAILGCDNLDYTELLNPSLTTIDISKFDMGVLAARILLGLLEDNKEPVRYIFEPKLVIREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3F0</accession>
    <name>B8E3F0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584099.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353638.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1752"/>
    <dbReference type="EnsemblBacteria" id="ACK43024">
        <property type="protein sequence ID" value="ACK43024"/>
        <property type="gene ID" value="Dtur_1752"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1752"/>
    <dbReference type="eggNOG" id="COG1609">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020864_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3F0"/>
    <dbReference type="OMA" id="ANDIMAI"/>
    <dbReference type="OrthoDB" id="664909at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046335">
        <property type="entry name" value="LacI/GalR-like_sensor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13377">
        <property type="entry name" value="Peripla_BP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="584"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="718" mass="83718" checksum="6477B7CA5C96343F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYH9</accession>
    <name>B8DYH9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SOS-response transcriptional repressor, LexA</fullName>
            <ecNumber evidence="15">3.4.21.88</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Dtur_0020</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="15"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582447.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351975.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0020"/>
    <dbReference type="MEROPS" id="S24.001"/>
    <dbReference type="EnsemblBacteria" id="ACK41361">
        <property type="protein sequence ID" value="ACK41361"/>
        <property type="gene ID" value="Dtur_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0020"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.20"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_45_1_0"/>
    <dbReference type="InParanoid" id="B8DYH9"/>
    <dbReference type="OMA" id="HVWLLPH"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="11" id="KW-0742">SOS response</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="LexA_DNA_bind" evidence="14">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="13">
        <location>
            <begin position="80"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACK41361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="199" mass="22351" checksum="EB0C8F98DBAB8B3C" modified="2009-03-03" version="1">MSKSILSKKQKEVLDFITSFWKKEGRIPTVREVSKALGLNSSGSGYFHMKALVEKGYLSQDKKGRFYLRNLINEEIIYLPLVGTIKAGIPVESPEYVDEYIPVPKSFVKIPEKSFLLKVKGDSMEGAHILDGDLIIVQKQDIAQKGEIVVALKDGESTVKFLSENYGIPCLKPANPRYSEIYPPFKIIGKVIGVIRLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYI1</accession>
    <name>B8DYI1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent pyridine nucleotide-disulphide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582449.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351977.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0022"/>
    <dbReference type="EnsemblBacteria" id="ACK41363">
        <property type="protein sequence ID" value="ACK41363"/>
        <property type="gene ID" value="Dtur_0022"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0022"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.22"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030705_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYI1"/>
    <dbReference type="OMA" id="HPGFGLH"/>
    <dbReference type="OrthoDB" id="912110at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="6"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="415" mass="46296" checksum="447E0B19A43521AA" modified="2009-03-03" version="1">MLKEVDIVIIGGGPAGLSAGISSGKKGKKVLILERNDELGGVLNQCIHPGFGLVYYKEELTGPEYAQRLIQEIKNLKNVEYFLNTMVLQVKEDKEVIAVNSDGLWKIKAKAVIFSTGCRERTRGNLQIPGDRPSGIYTAGTAQRLVNIEGYLPGEKILILGSGDIGLIMARRLLWEGAEVIGVVEKLPYPGGLTRNLVQCLEDYNIPLFLKHTVVEIKGKDRLEGVYIAPVDDQGNPIWEDKKFIECDTLLLSAGLIPENELLENLNIPIDIATGGPFVDQNLSTLKDGFFSCGNSLLVNDLVDYVTIQGLLAGESAVNFIEDALKIEKRIKLKISGNLRFVVPQYLSYPINLKDITFYMRVKEPQKKAKLSLKDKEKKLKEWRYPLVKPAEMIVVRIRSEDLYEVESLEFSMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYJ8</accession>
    <name>B8DYJ8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582466.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351994.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0042"/>
    <dbReference type="EnsemblBacteria" id="ACK41380">
        <property type="protein sequence ID" value="ACK41380"/>
        <property type="gene ID" value="Dtur_0042"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0042"/>
    <dbReference type="eggNOG" id="COG1664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072799_6_5_0"/>
    <dbReference type="InParanoid" id="B8DYJ8"/>
    <dbReference type="OMA" id="TDVVICD"/>
    <dbReference type="OrthoDB" id="1968497at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007607">
        <property type="entry name" value="BacA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35024">
        <property type="entry name" value="PTHR35024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04519">
        <property type="entry name" value="Bactofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="128" mass="13739" checksum="B12021472498B4C4" modified="2009-03-03" version="1">MLGKREKSEVMETIVGSQTEMEGTIISKASLRIDGKFKGDIEAKDTVIVGKTGYVEGNIKANRVVVIGEIVGNVICKESIEILSTGKLKGDLKLGGKISVEEGGILLGTTEILEEEKINDIFKIDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYN1</accession>
    <name>B8DYN1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cobyrinic acid ac-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0075</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582499.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352027.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0075"/>
    <dbReference type="EnsemblBacteria" id="ACK41413">
        <property type="protein sequence ID" value="ACK41413"/>
        <property type="gene ID" value="Dtur_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0075"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_2_0"/>
    <dbReference type="InParanoid" id="B8DYN1"/>
    <dbReference type="OMA" id="TRWDELD"/>
    <dbReference type="OrthoDB" id="1413173at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="245" mass="27989" checksum="BADBAED0CF145E8A" modified="2009-03-03" version="1">MTHDPRLSIIDKRLESVKNIIAIGSGKGGVGKSTFSSLLSLFLNKKGYKIGLLDLDIYGPSNHVILNAEDKYPEEEYGLKPVNVNGIDFMSIIYFTQNKPLIMRGKELTDTILEIFAITRWRDLDYLIIDMPPGMGEVLLDLIRFIKNLQFLIITNPTKIALETVEKLINFLKEGNYLILGLVENMKIKDGNFVKEKCQELNIKYLGHISFYENIEENYGNIEKLINPSLEKELNQIVSNFIQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYN7</accession>
    <name>B8DYN7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase family 2 sugar binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582505.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352033.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0081"/>
    <dbReference type="CAZy" id="GH2">
        <property type="family name" value="Glycoside Hydrolase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41419">
        <property type="protein sequence ID" value="ACK41419"/>
        <property type="gene ID" value="Dtur_0081"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0081"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.82"/>
    <dbReference type="eggNOG" id="COG3250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006501_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYN7"/>
    <dbReference type="OMA" id="ERWEYEV"/>
    <dbReference type="OrthoDB" id="1832114at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032311">
        <property type="entry name" value="DUF4982"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040605">
        <property type="entry name" value="Glyco_hydro2_dom5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006101">
        <property type="entry name" value="Glyco_hydro_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Glyco_hydro_2_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16355">
        <property type="entry name" value="DUF4982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18565">
        <property type="entry name" value="Glyco_hydro2_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00132">
        <property type="entry name" value="GLHYDRLASE2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="SSF49303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_2_N" evidence="6">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2" evidence="4">
        <location>
            <begin position="158"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_2_C" evidence="5">
        <location>
            <begin position="276"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4982" evidence="7">
        <location>
            <begin position="630"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro2_C5" evidence="8">
        <location>
            <begin position="702"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="808" mass="93534" checksum="09868D503E3B4E57" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYQ3</accession>
    <name>B8DYQ3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-mannanase/endoglucanase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352049.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0097"/>
    <dbReference type="CAZy" id="GH44">
        <property type="family name" value="Glycoside Hydrolase Family 44"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41435">
        <property type="protein sequence ID" value="ACK41435"/>
        <property type="gene ID" value="Dtur_0097"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0097"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.100"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015111_1_0_0"/>
    <dbReference type="InParanoid" id="B8DYQ3"/>
    <dbReference type="OMA" id="YWNMDNE"/>
    <dbReference type="OrthoDB" id="6800at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024745">
        <property type="entry name" value="Glyco_hydro_44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12891">
        <property type="entry name" value="Glyco_hydro_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_44" evidence="1">
        <location>
            <begin position="96"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="563" mass="63531" checksum="0D5B4DCD20B4153C" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYU0</accession>
    <name>B8DYU0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582557.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352086.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0141"/>
    <dbReference type="EnsemblBacteria" id="ACK41472">
        <property type="protein sequence ID" value="ACK41472"/>
        <property type="gene ID" value="Dtur_0141"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0141"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.147"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_0_0"/>
    <dbReference type="InParanoid" id="B8DYU0"/>
    <dbReference type="OMA" id="GRAMGFC"/>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="5">
        <location>
            <begin position="23"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="315" mass="35401" checksum="25323E77ADA15883" modified="2009-03-03" version="1">MKNSEGSIIWGEESFLYSFPEPHPMNRRRLESFDSEFKKFSNLSNVESPEMASYDEITLFHTKSYTDLVKEKSKTGEGYLDYGDTPAFLGCYEAASYVVGSTLKGIRLIVEGKYKRVFVPMAGLHHARRNSASGFCIFNDIGVAIEYLRKNYGIKNILYVDIDAHHGDGVFYEYVDDPHLFIADVHEDGRFLYPGTGRRDERGEKQAYGTKLNIPLLPGSGDDELLLAFEEVKNFAWEVKIEFIILQAGVDGISGDPITHLNYSIEGYGKFVEGMVDVANQTCGGKILILGGGGYNPENTKNGWMRVLRVIYGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYY1</accession>
    <name>B8DYY1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582692.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352221.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0282"/>
    <dbReference type="EnsemblBacteria" id="ACK41607">
        <property type="protein sequence ID" value="ACK41607"/>
        <property type="gene ID" value="Dtur_0282"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0282"/>
    <dbReference type="HOGENOM" id="CLU_2953008_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="59" mass="6997" checksum="6194998E34E852AE" modified="2009-03-03" version="1">MGDNLKNILRIILIYLVIGIFWVFLSHRFIDVLVKNANIIPLVYALNRKEKKNLLGRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYY3</accession>
    <name>B8DYY3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine kinase A domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352223.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0286"/>
    <dbReference type="EnsemblBacteria" id="ACK41609">
        <property type="protein sequence ID" value="ACK41609"/>
        <property type="gene ID" value="Dtur_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0286"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_697815_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYY3"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007234">
        <property type="term" value="P:osmosensory signaling via phosphorelay pathway"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033425">
        <property type="entry name" value="MASE3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17159">
        <property type="entry name" value="MASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="HisKA" evidence="2">
        <location>
            <begin position="324"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="395" mass="45720" checksum="F4BE5B679DE3693C" modified="2009-03-03" version="1">MPERTPFLQVIGTVFLSSAILDIPHTIYYAGFTGISNTGLSVIFWMFARFIQSCGLILAILHLKYKNLNTRFTSFTFLFPLLSILLIFLIKLLPTNIFHVEGLGTTTLKSVLEILYTLLFLTFSIKNKNNPYLLLSGVMFALSEIAFIKYASLFDWTLWFGHIFKILGVFNIAFYTLTNFIYNPLKDYKTLSDKYRREGEKLNETISKIISVQNNALETLSEAINYKDRKSLVEILRTFSEKENIEISVFSREKNIYSSSLHLPNAIEGYDAKKYCKIEGNETVIFIEKKDEIITKIYRLFILSIFSIFEKINYIDKLENLEKERKEFIKTVSHEFRNPLTIIFGQSQVLKSRFYSSPEKIKEIAEQIEISSKRISDLVDRLLKVGEEDGKDTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYZ1</accession>
    <name>B8DYZ1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0295</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582702.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352231.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0295"/>
    <dbReference type="EnsemblBacteria" id="ACK41617">
        <property type="protein sequence ID" value="ACK41617"/>
        <property type="gene ID" value="Dtur_0295"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0295"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.311"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="InParanoid" id="B8DYZ1"/>
    <dbReference type="OMA" id="PVMFMDE"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="298" mass="34073" checksum="FB11337A7A678A84" modified="2009-03-03" version="1">MNVIETHNLYKYYGIKKVLDDLNLEVPEGVIFGYLGPNGAGKTTTIRILLNLAKPTKGSVLVLGENISKSRKYLRRIGYLPDVPNFYNYFTAKEYLEVLSEIIGVDKKRVEEVLEIVGLKNEKKRIGAFSRGMKQRLGIAQALLPDPKLLILDEPTSSLDPQGRKEILDLILSLRGEKTVFFSTHILSDVERVCDRVGILREGRLLLNDTLDNIKKKLSRRIVKLKVDDPLRMMERVKKEDFVEEVLIKNQNSLIIKVKDLQRAGKKIPEIIVQENLSIMHFEVSEPTLEDIFFEVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ32</accession>
    <name>B8DZ32_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0345</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582743.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352272.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0345"/>
    <dbReference type="EnsemblBacteria" id="ACK41658">
        <property type="protein sequence ID" value="ACK41658"/>
        <property type="gene ID" value="Dtur_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0345"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_2_0"/>
    <dbReference type="InParanoid" id="B8DZ32"/>
    <dbReference type="OMA" id="DRHETQF"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="4">
        <location>
            <begin position="15"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="226" mass="26214" checksum="5C234C83479EE245" modified="2009-03-03" version="1">MADLLRPEIIYEDNHLLVVNKPAGVLVQGDITKSTTLLEISKAYIKEKYQKAGNVFLAIVHRLDKPVSGVVIFARNSKSAGRLSEAFRERKVEKEYLAICEGIFKIKKGTINESLFWDERERKAKISNKAESRVAITHYEVLEEFKNLSLVRLIPETGRKHQLRAHLSYIGHPILGDEKYGGVRIFKDKIFLHCRRMRIPHPVKKEIMEFKTEVPNFWSEFLKIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ33</accession>
    <name>B8DZ33_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582744.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352273.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0346"/>
    <dbReference type="EnsemblBacteria" id="ACK41659">
        <property type="protein sequence ID" value="ACK41659"/>
        <property type="gene ID" value="Dtur_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0346"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118536_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ33"/>
    <dbReference type="OMA" id="CHEVWEF"/>
    <dbReference type="OrthoDB" id="1890588at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="146" mass="17373" checksum="97C836F6D41E7634" modified="2009-03-03" version="1">MKKGLRLTIELIPESAWGENLRKYLPREVWNKIRREVLKKSGYKCAICGSSEKLQCHEVWEFDDENHILKLKGFMALCEKCHLVKHFGMAEILASEGKTNLEDLIKHFMKVNDCDRKTFEEHKKEAFKKFNERSRYEWLIDITVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ49</accession>
    <name>B8DZ49_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase BadF/BadG/BcrA/BcrD type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582760.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352289.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0371"/>
    <dbReference type="EnsemblBacteria" id="ACK41675">
        <property type="protein sequence ID" value="ACK41675"/>
        <property type="gene ID" value="Dtur_0371"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0371"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.390"/>
    <dbReference type="eggNOG" id="COG2971">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016274_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZ49"/>
    <dbReference type="OMA" id="QFSPAIF"/>
    <dbReference type="OrthoDB" id="1589192at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045127">
        <property type="term" value="F:N-acetylglucosamine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="1">
        <location>
            <begin position="4"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="322" mass="36208" checksum="399E8E6D60324078" modified="2009-03-03" version="1">MYFLGVDGGGTKTIAYLFDEEGNLIFKNTSGPTNILENGEEVFRKNLKELLSSILKDINPKDIKSCFGLPAVGEFREDIKILRNIIKDELKIEPDIIVNDVVIGWAGGNLARDGIHVVAGTGTITYGRKGNKDIRVSGWGSIIGDEGSAYYIGYRTLNEVSRELDGRKRKTDLTKLLFKKLSLKDHLDFIEFIYDPQKDRRSNIASVAKITYEIAKEGDKKALKILKDSAKELAITVTTANKFLKIKKPITVTYSGSVLEKNDIVREEFINILEKEGYKVEPPKLSPVLGAILLAFLSFGNKEKKRKFINKLLEIYKEENKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ80</accession>
    <name>B8DZ80_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MetI-like"/>
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        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
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        <location>
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            <end position="168"/>
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            <begin position="61"/>
            <end position="268"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS50928"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACK41813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
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    <sequence length="285" mass="32217" checksum="2F9E01D192873F14" modified="2009-03-03" version="1">MGKRNIITILLFLLPAFFYLSFLFIYPFLYGLNLSLTDEKGNFTLENFIRFFSDPWDANTIWITLKIAIPATLLSILIAIPLAYYMRHGVRGEKFVTLLLILPITLGSVFIAEGMLTYMGPNGWLNKLLMFLRITDKPVKLTHNYWGVLIALIIQGFPFVFLMLLGYISGIDPNLEKAASVLGANRWHIFWKVILPLWLPGITMAMSLNFVMNFTVFPSAVLLGQPSGPTRVISISAFQWAFEKFNFHMSSAVAIIMGIVELIFILIVMFIRQGLYRGSTVAGKG</sequence>
</entry>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
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                <person name="Brumm P.J."/>
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            </authorList>
            <dbReference type="PubMed" id="28066333"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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            <topology evidence="4">Multi-pass membrane protein</topology>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
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    </evidence>
    <sequence length="270" mass="30344" checksum="DD8EE891D443857F" modified="2009-03-03" version="1">MKRMGLSKALFWFTIIVYSFNILGIILTVVLNSLSKEWYGELFPKIFTFEWYAYMAREHDLPQLLYATFIVAISVALIALIIGLPTAYVLARYDFRLKNVILSFLLLPMLIPPMTYGIPLAALLYKLRLATKLSGVILANLVPVVPYVTLILTPFIEQIDISYESAARILGANRFQTFFKVLLPLIIPGIFTSALLSIVRTIAMFELTFLVAGPKSQTVVVALYYDAYAAGTRPPQAIDALAVVYFLITMTFLVIALRFASPTQFVYRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ97</accession>
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        </submittedName>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="55" mass="6396" checksum="8B0314E88521918A" modified="2009-03-03" version="1">MLAQTNLEGEKMYELIIYLAKSKGVLSLKDLEDITGLDKEELQEYIKDFHVRHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZC1</accession>
    <name>B8DZC1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0564"/>
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        <property type="gene ID" value="Dtur_0564"/>
    </dbReference>
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    <dbReference type="eggNOG" id="COG0715">
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        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="DUF3834"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="299" mass="34667" checksum="0D88DD6586E0F5E0" modified="2009-03-03" version="1">MKKKVFILIMLALLIIMNPIFSQNKKIEVLIPLGPTIIPFSTMISENPDFNFTIWRTLDELVVKARDNKYDVIIAPFTTLVNLYNKGVNIKYLSTFNFASFYLISNKAKRFNEIIGDNLYIAQKGSTQDIIFNIYLQERNLKDKINLYYSTPQEITSLFIAGKVNNALLPEPYVSMGVNNGGRIILDIQRVYREISKGRFLPITSIAVRGNIDKKEAQKIDSIFRENFKKFSQDPKDYIEKASEILKLDKKIIELSLKRLSFLYQGISIKNELIKYLEFIYEKNPQTIGNIPDEKFFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZD1</accession>
    <name>B8DZD1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide sugar dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.22</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582949.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352478.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0575"/>
    <dbReference type="EnsemblBacteria" id="ACK41864">
        <property type="protein sequence ID" value="ACK41864"/>
        <property type="gene ID" value="Dtur_0575"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0575"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.611"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_0"/>
    <dbReference type="InParanoid" id="B8DZD1"/>
    <dbReference type="OMA" id="GHCLPID"/>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="319"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="432" mass="48409" checksum="37E6949DBA5EBEBC" modified="2009-03-03" version="1">MSFKKISIVGLGYVGLPLALEFAKAGLIVHGIEQNPKKVEMVNKGISYIDDVKNDELLEVVNKGNLKAFIDFEPVKDSDAIIICVPTPLGPHKEPDISYIINVTTEISKYLKKGQLVVLESTTYPGTTEEVLVPILEKSGLKAGEDFYVAFSPERVDPGNKNFTTKDIPKVVGGINEVSTEKAMKLYSIIIPKIHKVSSPRVAEMEKLLENIFRLVNISFINELAILCRKMNIDIWEVISAASTKPYGFMPFYPGPGLGGHCIPIDPFYLSWKAKEYDFDVRFIELAGEINDNMPRYVVQLVMEALNNHRKPVNGSKILIIGVAYKPNIADPRESPALKIIPLLEDLGGEVEFYDPYVSEIKIENSKTKEVKYMKSCALDEGKVKNTDCVLIVTDHDNIDYEMIYKNAKLIVDTRNALRKRGLSIDERVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZD8</accession>
    <name>B8DZD8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-antigen polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0583</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582956.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352485.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0583"/>
    <dbReference type="EnsemblBacteria" id="ACK41871">
        <property type="protein sequence ID" value="ACK41871"/>
        <property type="gene ID" value="Dtur_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0583"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663336_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZD8"/>
    <dbReference type="OMA" id="YGMANDY"/>
    <dbReference type="OrthoDB" id="2082472at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="449" mass="51356" checksum="134B7501159BD3A1" modified="2009-03-03" version="1">MYGLKKLKVNINNSTLKVFNSIFTVLVYCLILLSESLFKYPEIYFALFLTAGVYKADPRLNFLPKFLDLTVFFGFLTTLGVLYNILKGELKPILPPIKIFLSYIFIVLLGILSLSYTLAPIYGTEKILRFIIITSPAFFFPIMLFQKKEVYVRFFAVFVIIAIIMSFDIITGGLAPGETGFHEALGSNYLAVGRISGIAILSALSLFFVIKQKLYKFCLLFIMGLFIFNMFISGGRGPLVSLAFSFVFIFIYLVIMNLFKIKENKFTINKRDFKLLSYIFLIFVFALFVVVYFKDYFSIIFYRLMLLENLEGTSIETRLKLYNTAINSLKDFPRNIVGLGIGGFSVFYNGYDAPRGLYPHNIFLEIGSELGILGLFAFIFVICKSIIVAFDNIKKSKLEWNYYINISLLMSLIFMLINSSVSGDINDNRLLFTTLGLIWARRRISNNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZF3</accession>
    <name>B8DZF3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582971.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352500.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0598"/>
    <dbReference type="EnsemblBacteria" id="ACK41886">
        <property type="protein sequence ID" value="ACK41886"/>
        <property type="gene ID" value="Dtur_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0598"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_516570_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZF3"/>
    <dbReference type="OMA" id="HIPDYEP"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870873" evidence="2">
        <location>
            <begin position="21"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="123"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="204"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="394"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="478" mass="52736" checksum="D6E2E824338FDED3" modified="2009-03-03" version="1">MKRLGIILIVALFLFSNIFAQTGEGTVSGVERIYFGKVIDPDKYVLGVGDIVRIYIILETEDPISFNVTVSPTGSINLPMVRAIKVSGLTLTEATREISKQLLKLYPRSNVIVDLVYPRNMKISITGEVTNPGIYSVSAISTLDDVIKLAGLKSSASLRNIQIRREDKVITVDYFRFLKYGDINANPYIQEGDLIYVPLMGKSVKVLGQVKNPGIYEIKDGEKLKDVLDMAGGLTAKADLLGGYIERQSDGKKQVISIDLFNLMYGKDNKENIVLKDGDSIVIPLKVDKVYVIGYVAKPQVFTIVSGESKSEVGGQPTLGESEIKEGAKISELIQKAGGVLPNGSRRRIQVIRDGQIIKEVDLFRVLVKGDAEEEKVKLVPGDIVYVPLVEKTVKILGEIKDPGIYEIKPGEKIKDIIDMAGGFTVRASLKDVTIERYITEKKQIIKLDLTKLYKDGDESVNISLEDGDIINIPIRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZH1</accession>
    <name>B8DZH1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dihydropteroate synthase</fullName>
            <ecNumber evidence="2">2.5.1.15</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.15" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582989.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352518.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0616"/>
    <dbReference type="EnsemblBacteria" id="ACK41904">
        <property type="protein sequence ID" value="ACK41904"/>
        <property type="gene ID" value="Dtur_0616"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0616"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.653"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZH1"/>
    <dbReference type="OMA" id="FSIDTYH"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="1">
        <location>
            <begin position="132"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="400" mass="45449" checksum="D9745746E342D3B5" modified="2009-03-03" version="1">MIVELSHEFLRKEILKVGAHPASLEIFERKAQIIPLKIFNISSPTANVIKQEMLSLGGDVVVHKNVVDCKIEKSDVILLGTKKHYELFIKKLENNKYFEIPLVLQELKEYLLKQKPEKIVSPWGRVLNLSRTLVMGIINVTPDSFYSGSRKMQINEVLKTVEDMVINGVDIIDIGGQSTRPGAEPVSIDEEMSRVIPAIESIRKSYPDVVISVDTYYSKVAELAVDRGADMINDISAFRFDNDLVKIVAKYKVPYILMHMKGTPKDMQKNPYYDDVVREIMEFFEERINYAKENGVDPEKIIVDPGIGFGKRYEDNLEIMARLKEFKSLRKPILIGASRKSFIGKALSDLPPEERLEGTLGITALCVLNDVDIVRVHDVKENKRVIKVLEEIKCIRSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZH7</accession>
    <name>B8DZH7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein Cas5, Hmari subtype</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582995.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352524.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0622"/>
    <dbReference type="EnsemblBacteria" id="ACK41910">
        <property type="protein sequence ID" value="ACK41910"/>
        <property type="gene ID" value="Dtur_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0622"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.659"/>
    <dbReference type="eggNOG" id="COG1688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090888_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZH7"/>
    <dbReference type="OMA" id="PWGHFRR"/>
    <dbReference type="OrthoDB" id="1815464at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013421">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_HALMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02592">
        <property type="entry name" value="cas_Cas5h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="238" mass="28055" checksum="D5A96326943978AD" modified="2009-03-03" version="1">MKVLVFDIFGDLAHFRRFYTTSSPLSFSFPPPPTILGMIGAIAGIDRKKYLEVLCPENCKISLQIMNPIKKIRLGLNLINTKDNFWQPVKTKNHNARTQVKTEFIKDPRYRVYFYHKDENIFEDVINKIKNHETFFTFSLGLSELIGDFQFIKVAEFIEIKEKEEVYIHSLLPMSYISESKIIFEEGKSYFRERIPVIMNKERVVEKYEDVIYESNGKPIKAFVNSYYKGENLNVIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZI7</accession>
    <name>B8DZI7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583005.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352534.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0632"/>
    <dbReference type="EnsemblBacteria" id="ACK41920">
        <property type="protein sequence ID" value="ACK41920"/>
        <property type="gene ID" value="Dtur_0632"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0632"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.669"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZI7"/>
    <dbReference type="OMA" id="DRARWYP"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="228" mass="26268" checksum="D8C9FDF4E3567A1B" modified="2009-03-03" version="1">MEILEISNLYKDYGKKLTLKNINLSFNLGEIVGLYGPNGSGKTTFLKIVVGLLKPSKGKVLVDGKEVGVYSKSIISYLPDRNIFPLWMKIKDTYKFYRDFFDFDDKKFKNLLDFFSLKEDLSLKALSKGDMEKLLLSLSLSRKAKIYLLDEPLSGIDPSTRDKIITSILKNYYEESLMIIATHLINEIETIADRTIFLYQGEIALDENTEKIREQKKISINELFKSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZL2</accession>
    <name>B8DZL2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phage shock protein C, PspC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583030.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352559.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0660"/>
    <dbReference type="EnsemblBacteria" id="ACK41945">
        <property type="protein sequence ID" value="ACK41945"/>
        <property type="gene ID" value="Dtur_0660"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0660"/>
    <dbReference type="eggNOG" id="COG1983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143433_0_2_0"/>
    <dbReference type="InParanoid" id="B8DZL2"/>
    <dbReference type="OMA" id="FMNPLMI"/>
    <dbReference type="OrthoDB" id="2022704at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007168">
        <property type="entry name" value="Phageshock_PspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04024">
        <property type="entry name" value="PspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PspC" evidence="7">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="81" mass="9336" checksum="B3AF697E0481474F" modified="2009-03-03" version="1">MEKKLYRSRKNRVILGVCGGIAEYLNIDPTIVRLIFIFLLIPFNFTLIILYFLSAFVIPEEPENIERKDDTITPSGPAQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZM3</accession>
    <name>B8DZM3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583041.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352570.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8DZM3"/>
    <dbReference type="STRING" id="515635.Dtur_0671"/>
    <dbReference type="CAZy" id="GH5">
        <property type="family name" value="Glycoside Hydrolase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41956">
        <property type="protein sequence ID" value="ACK41956"/>
        <property type="gene ID" value="Dtur_0671"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0671"/>
    <dbReference type="eggNOG" id="COG2730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018668_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZM3"/>
    <dbReference type="OMA" id="HRAPGYC"/>
    <dbReference type="OrthoDB" id="1395441at2"/>
    <dbReference type="BRENDA" id="3.2.1.4">
        <property type="organism ID" value="13721"/>
    </dbReference>
    <dbReference type="BRENDA" id="3.2.1.78">
        <property type="organism ID" value="13721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006073">
        <property type="term" value="P:cellular glucan metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cellulase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="331" mass="39392" checksum="FA8BD165193FEA25" modified="2009-03-03" version="1">MKIKNVIPRWKGFNLTNMFLFHLAKDFDEEDFKWISEWGFNFVRIPLCYRLWIEDDNVYKIKEEILEKIDKVVAWGQKYNIHVSLNFHRAPGYCVNNEFTEKFNLWRDESALDAFCFHWGIFAKRYKRVSSKYLSFNLVNEPLHPSPEVMTREDHNRVIRRTVEYIRNIDSERLIIIDGISYGNSPLPELSDLNVVQSCRGYLPMGLTHYKANWVGGENWPEPKWPGAWHYGEIWDREKLGRHYDEWAKLIGMGVGVHCGEAGAYKFTPHKVVIAWLRDLLEILKERDIGFALWNFKGPFGILDSDRSDVEYEDWYGHKLDREMLKLLQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZM9</accession>
    <name>B8DZM9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583047.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352576.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0677"/>
    <dbReference type="EnsemblBacteria" id="ACK41962">
        <property type="protein sequence ID" value="ACK41962"/>
        <property type="gene ID" value="Dtur_0677"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0677"/>
    <dbReference type="HOGENOM" id="CLU_581059_0_0_0"/>
    <dbReference type="OMA" id="HNTYYLA"/>
    <dbReference type="OrthoDB" id="2105790at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870880" evidence="1">
        <location>
            <begin position="21"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="470" mass="51938" checksum="E354F4BDF8F00A7D" modified="2009-03-03" version="1">MKKVLFLILALLLTLTFVYAQEVNFYGYSEIGVHSEFLKDSNGNYSNTLGPVNLDYWNTYFKIKAEPSSLLEGYFELHLYPNYSNLFGPGIIEVQKAHLIAKSSVMNLRVYYKEDATPFDDPLLLNKPGDLPGSSWIWGNGIEISGKAFDTNFLAGINSSDQISYVRLKRAFPPLMVGFTAMGSNWGQANVGKSLFGVDVTGKVANVDIKAEGIYGKCVWGPNPTDSEGGMVLYGDFSTQLTPVIKLYGIGKKVDKGYINQFDWFKTDQTQLIPGTSKSYGTYFKLGSVIAPISNLSFEPIVELINREDISQKTTNLTGIVTYIVSKNLTIKGTVNNSTVDSTNSTNVTLEATFVPLKDLSVYGKLYQPIGGNTELYGNLSTIYNNLSIYLAGNYTTNKSYLFLNAAYDLAKNLKLRGISQLFNDNGTKHNTYYLALELPNASLYFGNAPEEGTPADFVKQIGAKISFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZQ5</accession>
    <name>B8DZQ5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA methyltransferase, TrmA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0703</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583073.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352602.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0703"/>
    <dbReference type="EnsemblBacteria" id="ACK41988">
        <property type="protein sequence ID" value="ACK41988"/>
        <property type="gene ID" value="Dtur_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0703"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.741"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_0_0"/>
    <dbReference type="InParanoid" id="B8DZQ5"/>
    <dbReference type="OMA" id="SIIHVMN"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070041">
        <property type="term" value="F:rRNA (uridine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="448" mass="51487" checksum="E8496A553D33D4F4" modified="2009-03-03" version="1">MVKVGEEYQVKIEKINSQGQGIAYINSFVVFVDYALPGEVVKIKIHTAKRDYAVGKIVEFITKDPQRCEPACNVFYQCGGCHLMHVNYGYQLELKRMIVEDAFKRIGKIEKEISPVIGMENPYRYRNKAKIPVGKRRGKVVLGFYKPNTHHIVDISGCIVQHEDADKVIETTKEAIKKFHIEVYNELQHTGLLRFVVVRRSFAFDDLMVVLVSKGMIDNAKKIARFYRYRLKNLKSFYININPKRTNEIFGEESRLIWGEEVIRDKIGEFIFEISPVSFFQINSIQTEKLYNKALEYLSPNSKLVFDAYCGIGTISLFLSKKAEKVYGIEVERSAIEDAWKNARINKVKNVEFIWGRSEEVIPRLIEDGKIPDAIVLDPPRKGCDQNLLEAIIRAKVKQIIYISCYPSTLARDVNILVDAGYNLVNIQPVDMFPQTFHVENIALLEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZR0</accession>
    <name>B8DZR0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ribonuclease</fullName>
            <ecNumber evidence="12">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Dtur_0708</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 12">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="12"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583078.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352607.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0708"/>
    <dbReference type="EnsemblBacteria" id="ACK41993">
        <property type="protein sequence ID" value="ACK41993"/>
        <property type="gene ID" value="Dtur_0708"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0708"/>
    <dbReference type="eggNOG" id="COG1039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_646783_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZR0"/>
    <dbReference type="OMA" id="EYWTRIL"/>
    <dbReference type="OrthoDB" id="1702255at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="13">
        <location>
            <begin position="85"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK41993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="424" mass="49620" checksum="9684FBE1965C7AD2" modified="2009-03-03" version="1">MYGRSWKLDINESEKIKSYLIKMGGVEESIKNSYELWRIKLGGSTFIYYTSGKLYSTPSAKVINIWDEIDKLVSKSYDLNKDYVLGFDEVGKGEVFGPIITCGVLIRKDVISQIPSELKTPDTKKSHGFEYWTRILKVLEDLISDGFYYIIDIIQPREIDRFNINQLLDLSYMKLIKQLITDLPYRKEVRIVIDDYGVGEGLQRFLEIIKGENNFETIIVTESEDKFLEAKLASLIAKSYRESILKNLQERYEIPESLIKGNMSNKALESFLKNYSKDDLWFIRRSFGKRIKKEKPSFYNLISEDNFRCFFCGKESSKVILKDYRFLCSFCGKEIKDLELAMKYHSGIIKLEKESFYSFFEIIKNSYLFDGFSFLVDNSLRNLLTPYEDIGRILILKRAFSKFLTLKIEGDSIAFSFFRNIYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZV9</accession>
    <name>B8DZV9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="3">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:20345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583127.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352656.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0760"/>
    <dbReference type="EnsemblBacteria" id="ACK42042">
        <property type="protein sequence ID" value="ACK42042"/>
        <property type="gene ID" value="Dtur_0760"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0760"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.798"/>
    <dbReference type="eggNOG" id="COG0492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_0"/>
    <dbReference type="InParanoid" id="B8DZV9"/>
    <dbReference type="OMA" id="FRAEDYW"/>
    <dbReference type="OrthoDB" id="692968at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008255">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_2_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00573">
        <property type="entry name" value="PYRIDINE_REDOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="5">
        <location>
            <begin position="18"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="323" mass="35534" checksum="F71CD101127EF4CD" modified="2009-03-03" version="1">MEFISITKPIEKIEEVQDVIILGGGPAGLTAGIYTGRNLWRTLIIEKGILGGNAALTEKIDNYPGFPEGITGEELVKRMETQAKKFGSKILESDVLSLKIDGNWKIVETSQGTFRAPTLIIATGTRPRKLEVPGEEDFIGKGVSYCAVCDGAFFIRKKVAVIGGGDSAVEEAIYLTKFAEEVTIIHRRDTLRAEKITQQRAFSNPKIKFLWSHVVKAIEGEKKVERLVLEDLKTGETKIFPVDGVFIYVGLIPNTELFKDILNLDPNGFIITDEKMHTSMPGIYAAGDVRGKVLRQIVTAVADGAIAGMEASKFLEELNYKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZY0</accession>
    <name>B8DZY0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glucosamine-1-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.157</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.3.1.157" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352677.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0782"/>
    <dbReference type="EnsemblBacteria" id="ACK42063">
        <property type="protein sequence ID" value="ACK42063"/>
        <property type="gene ID" value="Dtur_0782"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0782"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.821"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_15_0_0"/>
    <dbReference type="InParanoid" id="B8DZY0"/>
    <dbReference type="OMA" id="RANPAQY"/>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="304" mass="34610" checksum="8B22E7CA623396D3" modified="2009-03-03" version="1">MFMNDFKAIILAAGQGKRMKTDLPKVLHPLYENTLLEFLLETVKTVFEKEYILVVSPKVRTYLNSISEENVVIQDVPLGTGDAVKRLENWLDAYEGDVLILPGDMPLIKSETLIKICNVHRENNNICTLVTTFLDNPCGYGRVVRDKSGEVLKIVEEKDATEEEKKIKEINTSVYAFKWRELREVLQLLKNDNAQGEFYLTDVIEIFNKRNLKIGTVVVDPVEVLGANTQEELSTLRKILKERINKINMNNGVIIIDPDTVIIGHKVSIEKDVIIQPEVFILGNYVIKKNSYIGPLSYINSKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZY4</accession>
    <name>B8DZY4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Single-stranded nucleic acid binding R3H domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583152.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352681.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0786"/>
    <dbReference type="EnsemblBacteria" id="ACK42067">
        <property type="protein sequence ID" value="ACK42067"/>
        <property type="gene ID" value="Dtur_0786"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0786"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.825"/>
    <dbReference type="eggNOG" id="COG1847">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022515_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZY4"/>
    <dbReference type="OMA" id="ILMLGRP"/>
    <dbReference type="OrthoDB" id="452951at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02645">
        <property type="entry name" value="R3H_AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034081">
        <property type="entry name" value="R3H_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045735">
        <property type="entry name" value="Spore_III_AA_AAA+_ATPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19568">
        <property type="entry name" value="Spore_III_AA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="SSF82708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="450"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="515" mass="57963" checksum="29D315498C321C9A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E052</accession>
    <name>B8E052_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583219.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352749.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0854"/>
    <dbReference type="EnsemblBacteria" id="ACK42135">
        <property type="protein sequence ID" value="ACK42135"/>
        <property type="gene ID" value="Dtur_0854"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0854"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.893"/>
    <dbReference type="eggNOG" id="COG2182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_17_0_0"/>
    <dbReference type="InParanoid" id="B8E052"/>
    <dbReference type="OMA" id="LWVDTEQ"/>
    <dbReference type="OrthoDB" id="1303718at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015144">
        <property type="term" value="F:carbohydrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901982">
        <property type="term" value="F:maltose binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042956">
        <property type="term" value="P:maltodextrin transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015768">
        <property type="term" value="P:maltose transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006060">
        <property type="entry name" value="Maltose/Cyclodextrin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00181">
        <property type="entry name" value="MALTOSEBP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="398" mass="43671" checksum="4F9303D3032442A8" modified="2009-03-03" version="1">MRKLSYVLMLISLMLLFLSLTGAQTNKITVWCSEKQVDILQRLGEEFKAKYGVSVDVQYVEFGSIKPNFLTAAPQGKGADVIVGAHDWVGELVVNGLLEPIAQFKDQNQFYTTALNAFSYGGKLYGLPYAMEAIALIYNKDYVKLPPSTFDALISTAKRIDTAYKGKVRGFITSGAEFYYVAPVLFGYGGYVFKETSKGLDVSDIGLANPGAIKGAKLWKRLFDEKILTPGDNYQIMDSMFKEGKAAMIINGPWAVKAYKDAGINYGVAVIPSLEKGVVAKPFVGVQGFMINAKSPNKILARDFVLNYIATKDTMYKIYLADPRIPARKDVLAMIKDNPDIVGFTKSAANGIPMPNVPEMAFVWSAMNDALNLIVNGKATPEEALENAVKAIKAQIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E072</accession>
    <name>B8E072_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583239.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352769.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0874"/>
    <dbReference type="EnsemblBacteria" id="ACK42155">
        <property type="protein sequence ID" value="ACK42155"/>
        <property type="gene ID" value="Dtur_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0874"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.912"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_0"/>
    <dbReference type="InParanoid" id="B8E072"/>
    <dbReference type="OMA" id="WELDCSY"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="360" mass="40177" checksum="032A450E046BDF41" modified="2009-03-03" version="1">MRDDLSIIEILQNALQKEASDVHITSGIPPVFRIKGHLIPQTQYPVLTPQLTYRLVFSLLTEEQKQKLQENKELDFSVGISGEGRFRVNAFWQRGSLAAVFRLIPWKIPTIEELRLPLVLKDLAALPRGLILVTGPTGSGKSTTLASMIDYINSNFSRHIITIEDPIEYLHTHKKSIVNQREVGSDTYSFANALRSALREDPDVILVGEMRDLETTAIAITAAETGHLVMATLHTVDAVQSIERIVDQFPAHQQQQIRLQLSGVIQGIISQQLLPRRDGTGRIVATEILIGIPAVRSLIREGKTPQIYSVIQTGGRYGMQTMDQSLADLVKKGLISQEVAFERAVNREELIRLLGGEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E077</accession>
    <name>B8E077_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prepilin-type N-terminal cleavage/methylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0879</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583244.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352774.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0879"/>
    <dbReference type="EnsemblBacteria" id="ACK42160">
        <property type="protein sequence ID" value="ACK42160"/>
        <property type="gene ID" value="Dtur_0879"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0879"/>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_7_1_0"/>
    <dbReference type="InParanoid" id="B8E077"/>
    <dbReference type="OMA" id="DENNDHY"/>
    <dbReference type="OrthoDB" id="2143137at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="2">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="141" mass="16034" checksum="93B4075A7E2AA3D8" modified="2009-03-03" version="1">MNKGGFSLIELLVVIVIISILALIGVSGYSMYLEKARESSAKSALKAIQVAVEMYSTDNKGKYPIANSLNELKAQILNYLPNREYPNNPYNNMPYSDENNDHYKITYTYDALENSYVLTVMDRYNIKRIYLLSNKITSIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8E091</accession>
    <name>B8E091_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583618.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353150.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1258"/>
    <dbReference type="EnsemblBacteria" id="ACK42536">
        <property type="protein sequence ID" value="ACK42536"/>
        <property type="gene ID" value="Dtur_1258"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1258"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073076_1_0_0"/>
    <dbReference type="InParanoid" id="B8E091"/>
    <dbReference type="OMA" id="EHCGRIL"/>
    <dbReference type="OrthoDB" id="833439at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="203"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="237" mass="28390" checksum="7C61A3E07BC6753D" modified="2009-03-03" version="1">MKRELIPKLLEIQDLQLKYRESEKNLKGLQAEFDIFKNEKLGEIKLKEENLINIRDQIKKLRDQQREKEDQLVLLKEKLTNEERRILILKNPKEVMHMEKEIENLKSLISKIEDEILNLMIELEEKTKTEKELEKAFNESKIAFDNKVKEYEEKIKNVENEIELLHIEIEDKRKEIPTDDLEEFDKLSKQKNYKPIARVNRDVCEGCKIAIPKVVLERVKRNEIVNCPNCGRILWVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E097</accession>
    <name>B8E097_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein archease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583624.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353156.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1264"/>
    <dbReference type="EnsemblBacteria" id="ACK42542">
        <property type="protein sequence ID" value="ACK42542"/>
        <property type="gene ID" value="Dtur_1264"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1264"/>
    <dbReference type="eggNOG" id="COG1371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111362_3_0_0"/>
    <dbReference type="InParanoid" id="B8E097"/>
    <dbReference type="OMA" id="KAVTWHA"/>
    <dbReference type="OrthoDB" id="1786857at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01222">
        <property type="entry name" value="Archease_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022952">
        <property type="entry name" value="Archease_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="6">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="138" mass="16364" checksum="711AB4415DF46D58" modified="2009-03-03" version="1">MKNYELLDHTADIGIIVYGETKEKAFESAAEAMFDLMCPLEKIQEKECFDIEVDGEDLESLLVTWLNELLYVFEVQKLLFRRFDVTLIGHNQLISHCYGERFDPKKHEITREIKAVTYNLLKIEQREDKWMIQVVFDI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0B1</accession>
    <name>NADD_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="1">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadD</name>
        <name type="ordered locus">Dtur_1278</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583638.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353170.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0B1"/>
    <dbReference type="SMR" id="B8E0B1"/>
    <dbReference type="STRING" id="515635.Dtur_1278"/>
    <dbReference type="EnsemblBacteria" id="ACK42556">
        <property type="protein sequence ID" value="ACK42556"/>
        <property type="gene ID" value="Dtur_1278"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1278"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1318"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_3_1_0"/>
    <dbReference type="InParanoid" id="B8E0B1"/>
    <dbReference type="OMA" id="IHIGHLI"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000192232" description="Probable nicotinate-nucleotide adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <sequence length="203" mass="24059" checksum="E6C417DE1451EDD4" modified="2009-03-03" version="1">MKIGILGGTFDPIHYGHLWFAEYAREKFKLDKVFFIPNRVPSHREIPIATSKQRYEMVLLATLNNPYFEVLPIELEREGVSYMVDTIRDLSTYFSNAELYLLLGNDAFRDFLKWKDPYKIVEKVSIIVGSRGEEYYTNDLKDFIKTFENKIFFLDFPYYPISAKEIRDRVKKGLSIKYLVPENVEEYIIKNSVYCEEDQKDVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0B4</accession>
    <name>RL21_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplU</name>
        <name type="ordered locus">Dtur_1281</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583641.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353173.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0B4"/>
    <dbReference type="SMR" id="B8E0B4"/>
    <dbReference type="STRING" id="515635.Dtur_1281"/>
    <dbReference type="EnsemblBacteria" id="ACK42559">
        <property type="protein sequence ID" value="ACK42559"/>
        <property type="gene ID" value="Dtur_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1281"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1321"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0B4"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000143787" description="50S ribosomal protein L21">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <sequence length="105" mass="12039" checksum="E58824C0F3B0E7F0" modified="2009-03-03" version="1">MFVVVETGGKQYKVSVGSMVNVEKLKANVGDEVVLDKVLLVGKEDEVIIGQPYVEGAKVIAKVVRQDKYPKVIVFKFKRKKHYRRKYGHRQPYTQLSIKEIVLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0H6</accession>
    <name>B8E0H6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate mutase sigma subunit</fullName>
            <ecNumber evidence="1">5.4.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate mutase S chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamate mutase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methylaspartate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmS</name>
        <name evidence="3" type="ordered locus">Dtur_1347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-3-methyl-L-aspartate = L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12857"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58724"/>
            <dbReference type="EC" id="5.4.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-glutamate degradation via mesaconate pathway; acetate and pyruvate from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer composed of 2 epsilon subunits (GlmE) and 2 sigma subunits (GlmS). GlmE exists as a homodimer and GlmS as a monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylaspartate mutase GlmS subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583702.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353235.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1347"/>
    <dbReference type="EnsemblBacteria" id="ACK42621">
        <property type="protein sequence ID" value="ACK42621"/>
        <property type="gene ID" value="Dtur_1347"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1347"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1392"/>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136705_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0H6"/>
    <dbReference type="OMA" id="GHGEMDC"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="UniPathway" id="UPA00561">
        <property type="reaction ID" value="UER00617"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050097">
        <property type="term" value="F:methylaspartate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019670">
        <property type="term" value="P:anaerobic glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019553">
        <property type="term" value="P:glutamate catabolic process via L-citramalate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02072">
        <property type="entry name" value="Glm_B12_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00526">
        <property type="entry name" value="Me_Asp_mutase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006394">
        <property type="entry name" value="GlmS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01501">
        <property type="entry name" value="MthylAspMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="1" id="KW-0170">Cobalt</keyword>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenosylcobalamin binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenosylcobalamin binding" evidence="1">
        <location>
            <begin position="61"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenosylcobalamin binding" evidence="1">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="137" mass="14983" checksum="45C1A7F430CB2E11" modified="2009-03-03" version="1">MGERTVVLGVIGADVHAVGLRVLDYVLRNAGFDVVNIGVLSSQEDFIKAAIESGARAILVSSLYGHAELDCKGFKEKLKEAGLEDIILYIGGNLGVGQKDWNEVEKKFKDLGFHRVYPPKTSPEDVVRDLKKDLGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0H9</accession>
    <name>B8E0H9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall hydrolase/autolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583705.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353238.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1350"/>
    <dbReference type="EnsemblBacteria" id="ACK42624">
        <property type="protein sequence ID" value="ACK42624"/>
        <property type="gene ID" value="Dtur_1350"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1350"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_491553_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0H9"/>
    <dbReference type="OMA" id="YIKSIRY"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="2">
        <location>
            <begin position="443"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="551" mass="63489" checksum="546E86E334BD2736" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0I1</accession>
    <name>B8E0I1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583707.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353240.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1352"/>
    <dbReference type="EnsemblBacteria" id="ACK42626">
        <property type="protein sequence ID" value="ACK42626"/>
        <property type="gene ID" value="Dtur_1352"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1352"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1397"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_0"/>
    <dbReference type="InParanoid" id="B8E0I1"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="4"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="37647" checksum="2E59692BF9F088BC" modified="2009-03-03" version="1">MGFILVTGGAGYIGSHVVKELLRRNYKVVVLDNLHKGHKKAVLTPYFEIVDLKKMDSLREVFEKYDIDAVMHFAALSTVAESMKEPFKYYENNILGGLNLLELMREYNIKYFIFSSTAAVYGEPQVVPIPEDHPKNPTNVYGSSKLMFEEILSWYDEIYKLRYVSLRYFNAAGADLEGELGEDHRPETHLIPIVLKTALGQREYIEIYGTDYPTPDGTCIRDYIHVVDLAEAHILALEALFDGMRSEVFNLGNERGYSVREVINIAEKVVGQKIPIKEGQRRLGDPAILIASSNKIKKVLKWQPKFNDLEIMISSAWNWMKKHPFGYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0I4</accession>
    <name>B8E0I4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylglutamate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583710.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353243.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1355"/>
    <dbReference type="EnsemblBacteria" id="ACK42629">
        <property type="protein sequence ID" value="ACK42629"/>
        <property type="gene ID" value="Dtur_1355"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1355"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1400"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0I4"/>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00354"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="256" mass="28391" checksum="018B5F6F68DE9316" modified="2009-03-03" version="1">MDKNLVLIKIGGNVLNKFSLFLSFIKDLYDKGYDFVFLHGGGNEINYWMERFGLEPKFVKGRRVTDENTLKIVEMVLSGEIQGRVISEIKKVGLKVVGLNGKSIFNCRKLFIDGIDLGYVGEVVGVEVSAIEKLLEERYIIVTTSLGIDEQGNSYNVNADSAALALGVHLKVERLIFCTDVPGIILKQNGEEVVLNKLSVEEAKRLIEIGEVFGGMIPKLESAIVAIENGVKTVQIWGGLDFSKAWNMEEGTLIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0I9</accession>
    <name>B8E0I9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583714.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353248.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1360"/>
    <dbReference type="EnsemblBacteria" id="ACK42634">
        <property type="protein sequence ID" value="ACK42634"/>
        <property type="gene ID" value="Dtur_1360"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1360"/>
    <dbReference type="eggNOG" id="COG4241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896381_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0I9"/>
    <dbReference type="OMA" id="KEPGHAI"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018710">
        <property type="entry name" value="DUF2232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09991">
        <property type="entry name" value="DUF2232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="310" mass="36240" checksum="372243A3B1BA001D" modified="2009-03-03" version="1">MNRSLQGLVEGSLITAINIVLAWFSYWFFPMIYFIPLPSLILTYRHGLRISILSLIISIILLSLMLSPFSAIFLMLPSGILGLYLGYGLQKKFNLRLLIVGSFTLLLFFEILSIYLSMILFKMPFEKVIGIDAMKEGWRKSLEIFRNYLGESNNEYIDMQNKFMENLHIFVPYFLIISTLFQVFLNYIIVERVLKRFKIEAPSLPNLEGFRISKKLLFSVLALYILFIFVNIPSKNIILSNLYLFLQTIILFNGYIFAWILLKHYISRKSLRILLFILFILNPIFGSIIFIVGFVDIFFPLREKLILKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0K8</accession>
    <name>B8E0K8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_1756</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584103.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353642.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1756"/>
    <dbReference type="EnsemblBacteria" id="ACK43028">
        <property type="protein sequence ID" value="ACK43028"/>
        <property type="gene ID" value="Dtur_1756"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1756"/>
    <dbReference type="eggNOG" id="COG0620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040013_3_1_0"/>
    <dbReference type="InParanoid" id="B8E0K8"/>
    <dbReference type="OMA" id="HPMLEDY"/>
    <dbReference type="OrthoDB" id="577156at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="12">
        <location>
            <begin position="87"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK43028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="325" mass="37871" checksum="B40F9E5BD4D87316" modified="2009-03-03" version="1">MIITVVDHYPKIPNPPKEPKLRKAIHAYDQGKITKEELEKIFDEVTQEVIQEQISAGVELITDGQIRWEDGQSYIAKKLDGAQIGGLIRYFDNNTYYRQPVIVGEIKWKEPIVIEDWKKAQKWAGNIPVKAVLTGPYTMARLSRDEHYKNFEKLVKAYTNALIEETKLLEENKVEYLQFNEPSIQYYPEDIDLFIDVYKEMRKYFSGNLAIYTYFHTVIPLKNRIKDLPIDTFGIDFVSRKENFEILKEFPKNLALGYGIVDARNTKLETPEQIADLIKQALQWISEDKLFVNPSCGLEYLPRERAYDKLVNLAKGVNLVRGEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0L4</accession>
    <name>B8E0L4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584109.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353648.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1762"/>
    <dbReference type="EnsemblBacteria" id="ACK43034">
        <property type="protein sequence ID" value="ACK43034"/>
        <property type="gene ID" value="Dtur_1762"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1762"/>
    <dbReference type="eggNOG" id="ENOG5033UIJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_475486_0_0_0"/>
    <dbReference type="OMA" id="PYTARNE"/>
    <dbReference type="OrthoDB" id="1654899at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK43034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="573" mass="64899" checksum="60D2FC2E8795AB5A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0L9</accession>
    <name>B8E0L9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalamin (Vitamin B12) biosynthesis CbiM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584114.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353653.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1767"/>
    <dbReference type="EnsemblBacteria" id="ACK43039">
        <property type="protein sequence ID" value="ACK43039"/>
        <property type="gene ID" value="Dtur_1767"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1767"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1819"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_2_1_0"/>
    <dbReference type="InParanoid" id="B8E0L9"/>
    <dbReference type="OMA" id="PWGTSGH"/>
    <dbReference type="OrthoDB" id="1632785at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="219" mass="23440" checksum="8F9444092A39684D" modified="2009-03-03" version="1">MHIPDGYLGPETYGSLFVLMVPFWAKAYNAVKKSLKEKDVPLLAISAAFSFVIMMFNIPIPGGTTGHAVGSVLIAILLGPWTATLVTSIVLIIQALIFGDGGITAIGANCFNMAIVMPFLGYYVYKLVKGKANLGSKREIISAGIGAYVGINVAALLTAIELGIQPYIAKDANGLPLYCPYPLKVAIPAMMVEHLLIFGIVEAVVTMAALYYLRKIENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0P5</accession>
    <name>B8E0P5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584139.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353679.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1793"/>
    <dbReference type="EnsemblBacteria" id="ACK43065">
        <property type="protein sequence ID" value="ACK43065"/>
        <property type="gene ID" value="Dtur_1793"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1793"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1845"/>
    <dbReference type="eggNOG" id="COG1906">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056143_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0P5"/>
    <dbReference type="OMA" id="PMPGGAY"/>
    <dbReference type="OrthoDB" id="801223at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007294">
        <property type="entry name" value="DUF401"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39556">
        <property type="entry name" value="PTHR39556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04165">
        <property type="entry name" value="DUF401"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="429" mass="48893" checksum="97445E5466A5959B" modified="2009-03-03" version="1">MIALLKVSIILGIIVVLLTKNFPLAWALLGGSLIMGISFGIPFNMILKGFWEGLSSLDTIKLVLILYLIALFENILREKDLLKNMVLSFKKLINDIRLRLISMPIIMGLLPSVGGALFSAPLLEELSKENNIDPERKSYINYWFRHVWEPFLPIYPGIILASVLTERPLNFFVREALPYGLAVLAIGLFFAFYRANSNQEYRQEKENLENPNEEITENLENLEETPTEEKKEEEIKNPLPTFLISILPILVLLILVIFLHSDLLYTLIGLNIVLFLVLKFDINRIKNLLLNSINIQNLILIVGVMIFKRMLEITGAVSDIAYSLNYSFIPTYLIFFALPLIIGIFTGVTSATVGITFPILIKMLPYQDPSKYIILAFISSFLGIMVSPLHLCLILTKEYFKPDWKSFYNYVLKSGVLLGIFILIKFFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0R2</accession>
    <name>B8E0R2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584156.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353696.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1811"/>
    <dbReference type="EnsemblBacteria" id="ACK43082">
        <property type="protein sequence ID" value="ACK43082"/>
        <property type="gene ID" value="Dtur_1811"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1811"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_0_0"/>
    <dbReference type="InParanoid" id="B8E0R2"/>
    <dbReference type="OMA" id="PPYSLFW"/>
    <dbReference type="OrthoDB" id="1351747at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="PTHR43150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="2">
        <location>
            <begin position="16"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="316" mass="35270" checksum="A6DDD55FB07C410D" modified="2009-03-03" version="1">MEYRKLGKAGVKLSVLGLGAWLTFGEKVDYDVTKECIATAIESGVNFIDLADVYARGEAERVVGKVIKDLGIRRQDLVISSKVYWPMSENVNDRGLSRKHIMESIDGSLKRLGVDYLDIYFCHRYDPETPIDEVVRAMDDLVHQGKILYWGTSVWSAAQIENAIGTAIKYNAYPPQVEQPRYNMLDRHIEPEIIPTCAKHGIGITVFSPLAQGILTGKYNNGIPAGSRASWSDWLKNELTEENIEKVRKLTNIAKELGITMSQLALAWILRKPEITSAIVGASKPDQLKETLKAGDIKLTEDVLEEIEKILANAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0X4</accession>
    <name>B8E0X4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Dtur_1437</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583789.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353325.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1437"/>
    <dbReference type="EnsemblBacteria" id="ACK42711">
        <property type="protein sequence ID" value="ACK42711"/>
        <property type="gene ID" value="Dtur_1437"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1437"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1484"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0X4"/>
    <dbReference type="OMA" id="RVNRQHH"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="13">
        <location>
            <begin position="161"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="430" mass="50139" checksum="CF318143D177F2F4" modified="2009-03-03" version="1">MEVRLRAAEILYDLERREAYLNILLRNRLPFYDLSLKEKHFITELVYGVTRWKITLDYIWSRFVRRDNLSLFSKVLLRLVVYHVYFLKDTILPVAVNEIVEIAKKKVPKEAKLINAVSRNIIREKNNLNLNSIPLHIRYGVPDFILEEWFDYIGRGEAVKALSWLNRSHNVSIRVNTLKISKKDLKEKLLERRIKFKDGNLVDQALIIEDGFDFERSDLFNEGYFVIQSEASMLPALILNPKPGNRVIDLCSAPGLKSTHLAELMKNQGKIISVDINKNRLRLVEENAKRLGISIIETFSQDVLNLPSSLDRSFDRVLLDAPCSGLGVISHKPEIKWRLKRDDIYNLSEMQVKMLERAGKLLKREGRMVYSTCTITWHENESVLLQFLQRNPEFKLVNFKYKGELFPGIMKVLPHKYNTDGFFIALIGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E111</accession>
    <name>B8E111_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA methyltransferase, TrmH family, group 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583826.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353362.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1474"/>
    <dbReference type="EnsemblBacteria" id="ACK42748">
        <property type="protein sequence ID" value="ACK42748"/>
        <property type="gene ID" value="Dtur_1474"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1474"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1523"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_0"/>
    <dbReference type="InParanoid" id="B8E111"/>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="1">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="239" mass="26474" checksum="F08D91513C0E9738" modified="2009-03-03" version="1">MEDIIYGKNSVLEALKSEIPLNKIYIARGIHFDNKFNEILKLAKEKSIPIKYVERSFIEKMVDGNSQGVLAILSSVPYKDWKELEKSLDNKSIIVVLDHIQDPYNLGAIARTSEFAGVSAIVIPKARSAGITSVSFKTSAGALSYIPVIRVSNIANFLRELKGKGWFIVGADLNTENLYNKVEYNFPLALVVGSEGEGLHRIVRESCDLLVKIPSYGKVESLNVSVAVGIILYKIRESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E175</accession>
    <name>B8E175_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="9">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lysS</name>
        <name evidence="11" type="ordered locus">Dtur_0922</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583287.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352817.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0922"/>
    <dbReference type="EnsemblBacteria" id="ACK42203">
        <property type="protein sequence ID" value="ACK42203"/>
        <property type="gene ID" value="Dtur_0922"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0922"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.959"/>
    <dbReference type="eggNOG" id="COG1384">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025562_1_0_0"/>
    <dbReference type="InParanoid" id="B8E175"/>
    <dbReference type="OMA" id="DWPMRWA"/>
    <dbReference type="OrthoDB" id="256927at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00177">
        <property type="entry name" value="Lys_tRNA_synth_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002904">
        <property type="entry name" value="Lys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042078">
        <property type="entry name" value="Lys-tRNA-ligase_SC_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37940">
        <property type="entry name" value="PTHR37940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01921">
        <property type="entry name" value="tRNA-synt_1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00467">
        <property type="entry name" value="lysS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Anticodon_2" evidence="10">
        <location>
            <begin position="431"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="32"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="279"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="524" mass="60182" checksum="D03A660780250CDC" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E177</accession>
    <name>B8E177_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352819.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0924"/>
    <dbReference type="EnsemblBacteria" id="ACK42205">
        <property type="protein sequence ID" value="ACK42205"/>
        <property type="gene ID" value="Dtur_0924"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0924"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.961"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815679_0_0_0"/>
    <dbReference type="OMA" id="HIGGGEP"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="340" mass="39408" checksum="0789BAD7D2A0D4B3" modified="2009-03-03" version="1">MLLPIDSLGIILTYKCSSRCRHCLYASGPEWTDFISREYLDSLLNGTKKIWKDYTPPPDKNILFHGIHFAGGEPFLNFPLLLYAVKKAKELGLYIGYVETNASWCINKEDVYEKFSLLKSSGLPKIFISCSPFHAEKIPLKRTLLAIETALEVFGPKNVIVYMEHFLGEIAKIDIENSIPLEKWIEIYGEKMAGYIFWEGYALIPGGRSGFYLGHLFKKYSAEVFREENCRFEILESQHAHFDLYGNYIPYFCGGLSLGKIEDLEEFYENFDLEKLPFVKILVEEGPYGLMKYAEKFGFKKSQEGYVGKCHLCVDVRRYINEIFPFSQELNPKNFYKYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1C5</accession>
    <name>B8E1C5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583337.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352867.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0973"/>
    <dbReference type="EnsemblBacteria" id="ACK42253">
        <property type="protein sequence ID" value="ACK42253"/>
        <property type="gene ID" value="Dtur_0973"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0973"/>
    <dbReference type="eggNOG" id="COG2119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140894_3_1_0"/>
    <dbReference type="InParanoid" id="B8E1C5"/>
    <dbReference type="OMA" id="HLHYIAG"/>
    <dbReference type="OrthoDB" id="2050363at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="90" mass="9909" checksum="10C495EB3E0C02A1" modified="2009-03-03" version="1">MDKIKILLSVFGVIFLAELGDKTQLAVLTLSVKTKSPFYVFLGASLALALVSFIGAYLGEALTRYIPRDTLEKIVGLIFILVGIWTIFKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1D9</accession>
    <name>RS3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name type="ordered locus">Dtur_0987</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583351.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352881.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1D9"/>
    <dbReference type="SMR" id="B8E1D9"/>
    <dbReference type="STRING" id="515635.Dtur_0987"/>
    <dbReference type="EnsemblBacteria" id="ACK42267">
        <property type="protein sequence ID" value="ACK42267"/>
        <property type="gene ID" value="Dtur_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0987"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1024"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_0"/>
    <dbReference type="InParanoid" id="B8E1D9"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000140959" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <sequence length="245" mass="27977" checksum="FD4786CFA26105BF" modified="2009-03-03" version="1">MGQKTHPYGFRLGITKDWKSHWYAERSDYSSLLHEDWAIRNYIKKNYYQAGISLIEIERKAANRVDITIHTARPGMLIGRGGSEIENIRKNLVKLTNKSVFVNVQEVKNPELDAQLVAENIATQIEKRINYKRAMKQAINRALRAGAKGVKVMCSGRLNGAEIARSEWFREGRIPLQTLTADIDYGFAEAFTISGVIGVKVWIYKGDVPELHKEPIQELPEKAVPKKIEDEDLYEKDEVNYDVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1E2</accession>
    <name>B8E1E2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="6" type="ordered locus">Dtur_0990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352884.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0990"/>
    <dbReference type="EnsemblBacteria" id="ACK42270">
        <property type="protein sequence ID" value="ACK42270"/>
        <property type="gene ID" value="Dtur_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0990"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1027"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1E2"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="112" mass="13043" checksum="E9087C32E3B46D70" modified="2009-03-03" version="1">MRSNRKEMIGKVVSAKMQKTIVVLVEQTYTHPLYKKTVTRRKKYKAHDEHQEAREGDIVLIRETRPLSKEKRWRLVRIIKRGEIAPTISEEENLENNETTVGVGDINDNASN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1E6</accession>
    <name>RS14Z_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsZ</name>
        <name evidence="1" type="synonym">rpsN</name>
        <name type="ordered locus">Dtur_0994</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583358.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352888.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1E6"/>
    <dbReference type="SMR" id="B8E1E6"/>
    <dbReference type="STRING" id="515635.Dtur_0994"/>
    <dbReference type="EnsemblBacteria" id="ACK42274">
        <property type="protein sequence ID" value="ACK42274"/>
        <property type="gene ID" value="Dtur_0994"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0994"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1031"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_0"/>
    <dbReference type="InParanoid" id="B8E1E6"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="OrthoDB" id="2032609at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000143900" description="30S ribosomal protein S14 type Z">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <sequence length="61" mass="7315" checksum="463694FC04ACD8F0" modified="2009-03-03" version="1">MAKKSQIVKWLKPKKYKVREYNRCRICGRPRGYIRKFGLCRLCFRELALKGEIPGVRKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1F5</accession>
    <name>B8E1F5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ordered locus">Dtur_1003</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583367.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352897.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1003"/>
    <dbReference type="EnsemblBacteria" id="ACK42283">
        <property type="protein sequence ID" value="ACK42283"/>
        <property type="gene ID" value="Dtur_1003"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1003"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1040"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1F5"/>
    <dbReference type="OMA" id="AHVSGKM"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="83" mass="9511" checksum="B55E9136F76E84D6" modified="2009-03-03" version="1">MDKKDREVIEVTGTVKEALPNATFKVQLDNGLEILAYISGKMRMNFIRVMPGDRVKVELSIYDLSKGRIIYRYTNKEGNKDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1G4</accession>
    <name>B8E1G4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583375.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352906.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1012"/>
    <dbReference type="EnsemblBacteria" id="ACK42292">
        <property type="protein sequence ID" value="ACK42292"/>
        <property type="gene ID" value="Dtur_1012"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1012"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1049"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_2_2_0"/>
    <dbReference type="InParanoid" id="B8E1G4"/>
    <dbReference type="OMA" id="MTRAINW"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="267" mass="30967" checksum="C4774D8DAFC0F03A" modified="2009-03-03" version="1">MEVLKTFPIGQYIPANSILHGLDAKAKIIASFWLIVFIFLIRLNLSYLFFFLLIMLGIFLSSLPLKYFLRSLKPVYFLVLFTFIIHFFFGEEGGRVFWRFGIIHITELGIKMAIFMSLRLIFIVMITSLLTLTTSVLELAQALEDLLKPLKYFKFPVHEFSMMMTIAIRFVPTLLDETDKIIKAQKARGAEFGKGNIVNQAKSLLPVIIPLFVNAFRRANELAEAMESRCYRGGEGRTRYRRTYWTLKETSFIFFIGIYSALLLIFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1G5</accession>
    <name>TRUA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="1">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truA</name>
        <name type="ordered locus">Dtur_1013</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583376.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352907.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1G5"/>
    <dbReference type="SMR" id="B8E1G5"/>
    <dbReference type="STRING" id="515635.Dtur_1013"/>
    <dbReference type="EnsemblBacteria" id="ACK42293">
        <property type="protein sequence ID" value="ACK42293"/>
        <property type="gene ID" value="Dtur_1013"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1013"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1050"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1G5"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000194548" description="tRNA pseudouridine synthase A">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <sequence length="245" mass="29237" checksum="40D8EC13B3DA2398" modified="2009-03-03" version="1">MTNWKLEISYIGKDFYGFQKQPGKRTIQGELEKVLSFLFDEEIRVIGAGRTDTGVHALGQVVNFKSRGHKGFSCDKLHKVLNRLLPEDIKIKKVEIVDDSFHARYSAKRRWYIYVVYNNDERDLFLKDYSWWISREINRELLIFSANLFKGVHDFKNFCVTEDEDQTVIEVYESFWYFKKDLLIYFISAPFFLRKMVRFIVGSMVEIALGRKSLIELEDYLKEERKERFSVPAPPWGLYLFRVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1H5</accession>
    <name>B8E1H5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Hypoxanthine phosphoribosyltransferase</fullName>
            <ecNumber evidence="1 2">2.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>diphosphate + IMP = 5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:17973"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="2.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.8" evidence="1 2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582585.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352114.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0169"/>
    <dbReference type="EnsemblBacteria" id="ACK41500">
        <property type="protein sequence ID" value="ACK41500"/>
        <property type="gene ID" value="Dtur_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0169"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.175"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1H5"/>
    <dbReference type="OMA" id="TMDWMAV"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00648"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052657">
        <property type="term" value="F:guanine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004422">
        <property type="term" value="F:hypoxanthine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032263">
        <property type="term" value="P:GMP salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006178">
        <property type="term" value="P:guanine salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046100">
        <property type="term" value="P:hypoxanthine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005904">
        <property type="entry name" value="Hxn_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01203">
        <property type="entry name" value="HGPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="3">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="174" mass="20065" checksum="737B2E291CBA82BB" modified="2009-03-03" version="1">MEKIGKILFTKEEIEKRIKELGEEISKDYIYKDLVLACVLKGAVYFTVDLTRNLSVPFVLDFISILSYGSSRESQGIVRIIKDLDVNIYNKDVLIIEDIVDTGLTLSYLIRNLQAKNPSSIKVCTLLDCPGRRIIDIDVDYKGFEIPNYYVIGYGLDYKEKYRNLPYIAILEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1I2</accession>
    <name>B8E1I2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582592.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352121.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0176"/>
    <dbReference type="EnsemblBacteria" id="ACK41507">
        <property type="protein sequence ID" value="ACK41507"/>
        <property type="gene ID" value="Dtur_0176"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0176"/>
    <dbReference type="HOGENOM" id="CLU_1560506_0_0_0"/>
    <dbReference type="OMA" id="SIENAWM"/>
    <dbReference type="OrthoDB" id="2114054at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870917" evidence="1">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="171" mass="19320" checksum="EEE86A0E5951B522" modified="2009-03-03" version="1">MKKCLLGLLILVLLLAFTFADDDFIVATKFEEQNGEGYWGPYGPAYKLENGVLVFDSSIENAWMTLNFKDDFMEAEDYRYVVITIKADDPKDAQNIVMTLGNLKKTFTDWGITLTTDFKTYVIDLFAHGLKNWGDGTKAEPDLAFNKAGAIKAKIYVKSMILTNNPTKYTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1I9</accession>
    <name>B8E1I9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Histidinol-phosphatase</fullName>
            <shortName evidence="7">HolPase</shortName>
            <ecNumber evidence="4 7">3.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0185</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PHP hydrolase family. HisK subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="4 7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582599.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352128.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0185"/>
    <dbReference type="EnsemblBacteria" id="ACK41514">
        <property type="protein sequence ID" value="ACK41514"/>
        <property type="gene ID" value="Dtur_0185"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0185"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.191"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054611_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1I9"/>
    <dbReference type="OMA" id="YAIGSVH"/>
    <dbReference type="OrthoDB" id="1615112at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010140">
        <property type="entry name" value="Histidinol_P_phosphatase_HisJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21039">
        <property type="entry name" value="PTHR21039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01856">
        <property type="entry name" value="hisJ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHP" evidence="8">
        <location>
            <begin position="4"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="269" mass="32171" checksum="4510AF3AE452DB58" modified="2009-03-03" version="1">MLIDYHMHLERGPFEENWWLKFYEKAKERNIKELGISEHGHRFKEFRPIYNHLPITESWCDSNLYEYKEFTMFLKKKYNLKIGLEMDYFPEKEKEIKELLQEYNFFDYVLGSVHFIDQGFGFDIDPNDPRWTERDIEEIFEDYFDKVEKLIKSNLFDVIAHLDVVKLWGVRKPKNLNNLYEKIAKVIINSNISLELNTAGWRKPVNEVYPSPEFLRILAPYDVPLTFGADAHTPEDVGRDIQKAYNLAKELGFKKLSIFNKRDKIVVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1K9</accession>
    <name>B8E1K9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352148.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0205"/>
    <dbReference type="EnsemblBacteria" id="ACK41534">
        <property type="protein sequence ID" value="ACK41534"/>
        <property type="gene ID" value="Dtur_0205"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0205"/>
    <dbReference type="HOGENOM" id="CLU_2023048_0_0_0"/>
    <dbReference type="OrthoDB" id="1618063at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="122" mass="14540" checksum="8523E2957B6E8775" modified="2009-03-03" version="1">MYDLEHVWVYIKGNWHGKYRNFEEFQVIDGHPVIYAQPGKHSFASVKEYFNGDLFNYLRTIISCKFFAGKSGILQKGYNIELKRGDEEFKKEIPERISYLLTNIRENFNFPLTYSYSNLIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1R4</accession>
    <name>B8E1R4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582782.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352311.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0393"/>
    <dbReference type="EnsemblBacteria" id="ACK41697">
        <property type="protein sequence ID" value="ACK41697"/>
        <property type="gene ID" value="Dtur_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0393"/>
    <dbReference type="HOGENOM" id="CLU_2381533_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="94" mass="10884" checksum="B0A4671BBCCC143D" modified="2009-03-03" version="1">MNLQETLSVPSLSLNSKSVYTLKDLARSEEVKRYVEVFLKDWEELKDLESGGVPEDEINKKKQEILEEIQELRRIAEKNGESEEFSNILNSRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1T4</accession>
    <name>B8E1T4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic binding protein/LacI transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582802.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352331.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0413"/>
    <dbReference type="EnsemblBacteria" id="ACK41717">
        <property type="protein sequence ID" value="ACK41717"/>
        <property type="gene ID" value="Dtur_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0413"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.436"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_3_0"/>
    <dbReference type="InParanoid" id="B8E1T4"/>
    <dbReference type="OMA" id="YHFYMVA"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="27"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="312" mass="33856" checksum="16C1CF0F3DF95915" modified="2009-03-03" version="1">MKRFLIVTLISLFLIGFSITSAQRPYIAMISKGFQHQFWQAVKMGAEKAAKDLNVTITFEGPESEAMVDKQIEMLQAALAKKPAALCIAALDSKAVIPYLEKAHAMGIPVIGFDSGVDSDIPVTTVATDNIKAAGYAADMMAKFINRVGEVALVVHDQVSRTGIDRRDGFVNRIKAKYPLIKIVDIQYGGGDHLKSTDLTKAIIQAHPRLKGIFGANEGSAIGVINAVREMNKVGKIVVIGYDSGKQQIDAIKSGLMAGAITQNPVGMGYMAVEAAVKAIKGEKLPKFIDSGFYWYDKTNIDDPKIKQCLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1V8</accession>
    <name>B8E1V8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582826.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352355.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0439"/>
    <dbReference type="EnsemblBacteria" id="ACK41741">
        <property type="protein sequence ID" value="ACK41741"/>
        <property type="gene ID" value="Dtur_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0439"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.464"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_1_0"/>
    <dbReference type="InParanoid" id="B8E1V8"/>
    <dbReference type="OMA" id="WYPLTLG"/>
    <dbReference type="OrthoDB" id="1074175at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="73"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="279" mass="31630" checksum="B3CB32D794B4162A" modified="2009-03-03" version="1">MRKKTLNTIIYYTFVTIIAFFMVYPALWMLSSSFKQPWEIFGNILSLIPKEPTLHNYKEGWQGFGGITFATFFKNSFIIAGLNTIGTVLSSTIVAYGLSRIPFPGRRMIFTTVILTLMLPMQVQIVPRYILFSKLGWINTFYPLIVPAFLGGPFFIFMVMQFIRGIPKELDESAFIDGADRIKIFYYVILPNLKPVVTTAAIFAFYWAWNDFMGPLVYLNSPEKYPVSVALRAFSDPSAVTNWGAVFAMSTLSLIPVLVIFVLFQKYIVQGVTTTGLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Z8</accession>
    <name>B8E1Z8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0483</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582866.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352395.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0483"/>
    <dbReference type="EnsemblBacteria" id="ACK41781">
        <property type="protein sequence ID" value="ACK41781"/>
        <property type="gene ID" value="Dtur_0483"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0483"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_0"/>
    <dbReference type="InParanoid" id="B8E1Z8"/>
    <dbReference type="OMA" id="SAIMNFQ"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="227" mass="26593" checksum="572C316965AB8106" modified="2009-03-03" version="1">MKSLEPIEESLISIKVYESIREAIISGQFPSGTKLTVDMLSEELKVSRTPVKEALVRLEREGLVENIPRKGMFVARIDIEDAIEIYELREVLEGFAVRKFCENLDEETLKELKELLEEGEKFIAQGKLKKYSDIDEKFHKTIWNKSKNKRLFRFLENIRSQIRLLMASSVNILGRAEESLREHKNILKALEERNPNLAEEYMKLHIRNTKEVALKNYLEKSEIKEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E212</accession>
    <name>B8E212_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582880.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352409.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0502"/>
    <dbReference type="EnsemblBacteria" id="ACK41795">
        <property type="protein sequence ID" value="ACK41795"/>
        <property type="gene ID" value="Dtur_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0502"/>
    <dbReference type="eggNOG" id="COG3533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013148_1_0_0"/>
    <dbReference type="InParanoid" id="B8E212"/>
    <dbReference type="OMA" id="LYSGMAD"/>
    <dbReference type="OrthoDB" id="194265at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Glyco_hydro_127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Glyco_hydro_127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="617" mass="71321" checksum="3963C3A1916D4462" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E215</accession>
    <name>B8E215_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Beta-galactosidase</fullName>
            <shortName evidence="5">Beta-gal</shortName>
            <ecNumber evidence="3 5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_0505</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 42 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582883.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352412.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0505"/>
    <dbReference type="CAZy" id="GH42">
        <property type="family name" value="Glycoside Hydrolase Family 42"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41798">
        <property type="protein sequence ID" value="ACK41798"/>
        <property type="gene ID" value="Dtur_0505"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0505"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.536"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012430_1_1_0"/>
    <dbReference type="InParanoid" id="B8E215"/>
    <dbReference type="OMA" id="HINNEYC"/>
    <dbReference type="OrthoDB" id="831762at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013739">
        <property type="entry name" value="Beta_galactosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013738">
        <property type="entry name" value="Beta_galactosidase_Trimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003476">
        <property type="entry name" value="Glyco_hydro_42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36447">
        <property type="entry name" value="PTHR36447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08533">
        <property type="entry name" value="Glyco_hydro_42C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08532">
        <property type="entry name" value="Glyco_hydro_42M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001084">
        <property type="entry name" value="B-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Glyco_hydro_42" evidence="9">
        <location>
            <begin position="14"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42M" evidence="10">
        <location>
            <begin position="403"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_42C" evidence="11">
        <location>
            <begin position="626"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK41798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="683" mass="79794" checksum="B0AC770125F463F1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E249</accession>
    <name>B8E249_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ordered locus">Dtur_1046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583409.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352940.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1046"/>
    <dbReference type="EnsemblBacteria" id="ACK42326">
        <property type="protein sequence ID" value="ACK42326"/>
        <property type="gene ID" value="Dtur_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1046"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1083"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_3_0"/>
    <dbReference type="InParanoid" id="B8E249"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="53"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="163"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="264" mass="29463" checksum="BF6A1C0D81BDABB1" modified="2009-03-03" version="1">MEIKLQKIGVFYNPKKREAKKGIDILKDWAERRGIEVIPEGSNVDLGVAIGGDGTVLYTLQKLSIYNIPVVGINTGRLGFLTTVEFKDIDVLLDSIEKGNFFIEKHPVIKLTIDQNVFYAFNEVVFLKSENTPLISINFIFNNGSILTPPADGVIVATSAGSTAYALSAGGAIIFPELEVTEVIPICAHSLSSRPLVLDLNNINIQVKFQRKSTQVEIWIDGKEIDIVSNKNEITISKADFYGRLIFLPGWDFVNRLKKKLHWR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E257</accession>
    <name>AROE_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="1">SDH</shortName>
            <ecNumber evidence="1">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroE</name>
        <name type="ordered locus">Dtur_1054</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583417.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352948.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E257"/>
    <dbReference type="SMR" id="B8E257"/>
    <dbReference type="STRING" id="515635.Dtur_1054"/>
    <dbReference type="EnsemblBacteria" id="ACK42334">
        <property type="protein sequence ID" value="ACK42334"/>
        <property type="gene ID" value="Dtur_1054"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1054"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1091"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_1_0"/>
    <dbReference type="InParanoid" id="B8E257"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="OrthoDB" id="1054867at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000118873" description="Shikimate dehydrogenase (NADP(+))">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="153"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <sequence length="275" mass="31338" checksum="0999EFB76033C70A" modified="2009-03-03" version="1">MISPSTKLYGLIGYPLGHSISFYIHNAAFRALSIDALYLNIPIEPEFFSKAILGIKYLPIYGLNVTIPHKESIIEFLDEISEISNILGAVNTVYRENHKWKGDNTDFGGFLKTLEDLNLSSDFSCLILGAGGAARAVIYAVLEYGFKEVYLTNRTYERAEKIAVEVKKNKNFEIKVIPWEDREKISEKVILINTTSIGLDGKETPWNGDFKKLVFVYDIIYNPKETPLLKLAKENNVPYKNGLDMLIYQACLSWEKWFGFVGPFEVMKREAEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E263</accession>
    <name>B8E263_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TrpR like protein, YerC/YecD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583423.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352954.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1060"/>
    <dbReference type="EnsemblBacteria" id="ACK42340">
        <property type="protein sequence ID" value="ACK42340"/>
        <property type="gene ID" value="Dtur_1060"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1060"/>
    <dbReference type="eggNOG" id="COG4496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147939_1_0_0"/>
    <dbReference type="InParanoid" id="B8E263"/>
    <dbReference type="OMA" id="DECYRFF"/>
    <dbReference type="OrthoDB" id="1926997at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000831">
        <property type="entry name" value="Trp_repress"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038116">
        <property type="entry name" value="TrpR-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013368">
        <property type="entry name" value="YecD_YerC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40080">
        <property type="entry name" value="PTHR40080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01371">
        <property type="entry name" value="Trp_repressor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012508">
        <property type="entry name" value="YerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02531">
        <property type="entry name" value="yecD_yerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="99" mass="11559" checksum="95F4E5C9B29E9784" modified="2009-03-03" version="1">MSYNPKWIDDDIYFLVKALLTLKNEEEVLRFLEDICTITEIKELSQRLKVAKMLYEGKSYEEIERETGTSSATISRVKKFLLYGAEGYKTVLDRLIKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E294</accession>
    <name>B8E294_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ion-translocating oxidoreductase complex subunit D</fullName>
            <ecNumber evidence="10">7.-.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Rnf electron transport complex subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rnfD</name>
        <name evidence="11" type="ordered locus">Dtur_1092</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the NqrB/RnfD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.-.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583454.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352985.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1092"/>
    <dbReference type="EnsemblBacteria" id="ACK42371">
        <property type="protein sequence ID" value="ACK42371"/>
        <property type="gene ID" value="Dtur_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1092"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1128"/>
    <dbReference type="eggNOG" id="COG4658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042020_1_0_0"/>
    <dbReference type="InParanoid" id="B8E294"/>
    <dbReference type="OMA" id="GWQWINL"/>
    <dbReference type="OrthoDB" id="1654433at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00462">
        <property type="entry name" value="RsxD_RnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004338">
        <property type="entry name" value="NqrB/RnfD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011303">
        <property type="entry name" value="RnfD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578">
        <property type="entry name" value="PTHR30578"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30578:SF0">
        <property type="entry name" value="PTHR30578:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03116">
        <property type="entry name" value="NQR2_RnfD_RnfE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01946">
        <property type="entry name" value="rnfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="modified residue" description="FMN phosphoryl threonine" evidence="10">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="318" mass="34857" checksum="D6D23A0F654FE788" modified="2009-03-03" version="1">MELENEKLIVSSSPHIFTTEDTSYAMRQVILALLPATLAGIYFFGFYALIVILVSVVSSVLWEALALYIRRKPLSILKDYSAVVTGLLLALILPPNVPFWIPIIGTGVAILLAKQVFGGIGENFLNPALVGRAFLLSSYPQIMTSWVKPIGGLGFMSNLSTATPLAIEKLKLTGYSLPSYWDLFIGNRAGCIGETSILLLLLGGLWLIYKNIIDWKIPVSFILTVFIMSFLLGKDPIFQILSGGLFLGAFFMATDWVTTPLTSKGRLIFGIGAGLFTIVIRFWGAYPEGVSYGILVMNALTPLIDNLVKPHRFGEVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2C0</accession>
    <name>B8E2C0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAGPA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353011.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1118"/>
    <dbReference type="EnsemblBacteria" id="ACK42397">
        <property type="protein sequence ID" value="ACK42397"/>
        <property type="gene ID" value="Dtur_1118"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1118"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1154"/>
    <dbReference type="eggNOG" id="COG4632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_401022_0_0_0"/>
    <dbReference type="OMA" id="IINGNFF"/>
    <dbReference type="OrthoDB" id="1587976at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033299">
        <property type="term" value="P:secretion of lysosomal enzymes"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018711">
        <property type="entry name" value="NAGPA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09992">
        <property type="entry name" value="NAGPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002871071" description="NAGPA domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="NAGPA" evidence="2">
        <location>
            <begin position="234"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="686" mass="78012" checksum="99EB3FE7F78ABBD1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-01" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2D1</accession>
    <name>Y1129_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein Dtur_1129</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Dtur_1129</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583491.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353022.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2D1"/>
    <dbReference type="SMR" id="B8E2D1"/>
    <dbReference type="STRING" id="515635.Dtur_1129"/>
    <dbReference type="EnsemblBacteria" id="ACK42408">
        <property type="protein sequence ID" value="ACK42408"/>
        <property type="gene ID" value="Dtur_1129"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1129"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1166"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059558_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2D1"/>
    <dbReference type="OMA" id="TVMSFGF"/>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383242" description="Nucleotide-binding protein Dtur_1129">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <sequence length="294" mass="33661" checksum="DE262617AB7DD2BB" modified="2009-03-03" version="1">MDFQVFIITGLSGAGKSQSLRILEDLGFFCVDNIPPKLVPTLIDLCLATNGKISGLAVVIDIRTENFLESFKEMVEIIKSRNIPYKILFLEAKDEVIVKRYNETRRIHPLLKEGGTILESIRLEKEKLWEIRNLATDIVNTSDFSIKELKEVILKIVTSLNTTVKPNFLITITSFGFKYGVPIDAHLVFDVRFLPNPFYDPKLRPFSGKSEEVRGFVLSKKEARDFIEHIKKLLDFLIPLYEEEGRTVLNIAIGCTGGRHRAVVIADEIFFYLAPKYNTHLLHRDIEKDVHILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2D7</accession>
    <name>B8E2D7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583859.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353395.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1507"/>
    <dbReference type="EnsemblBacteria" id="ACK42781">
        <property type="protein sequence ID" value="ACK42781"/>
        <property type="gene ID" value="Dtur_1507"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1507"/>
    <dbReference type="HOGENOM" id="CLU_2192828_0_0_0"/>
    <dbReference type="OMA" id="LEEEYYW"/>
    <dbReference type="OrthoDB" id="2173389at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="108" mass="13292" checksum="E9600AECCA096DB1" modified="2009-03-03" version="1">MMEEKVKDIVSFISAKEKEVEIEVEKAKKELEEEYYWKVQEYSIKMEEEKQRFLNDLRGEEESCRKALKLKLEKMEQEYIDEINKYRKDVENRISYIVDFLLSKLIQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2F5</accession>
    <name>TRMFO_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="1">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmFO</name>
        <name type="ordered locus">Dtur_1525</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583875.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353413.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2F5"/>
    <dbReference type="SMR" id="B8E2F5"/>
    <dbReference type="STRING" id="515635.Dtur_1525"/>
    <dbReference type="EnsemblBacteria" id="ACK42799">
        <property type="protein sequence ID" value="ACK42799"/>
        <property type="gene ID" value="Dtur_1525"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1525"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1574"/>
    <dbReference type="eggNOG" id="COG1206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033057_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2F5"/>
    <dbReference type="OMA" id="MHRNTFL"/>
    <dbReference type="OrthoDB" id="516534at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000149471" description="Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <sequence length="439" mass="49874" checksum="5823EEBA924B2AFA" modified="2009-03-03" version="1">MEKVKIIGGGLAGSEAAWQLAKRKIPVEIYEMRPIVTTPVHKTEYLAELVCSNSFKSTEITNASGLLKEEMRKLDSLLLRVAEETRVPAGVALAVDRELFSKRVQEILLESPYVTVIREEVKKLPKEGIVIVATGPLTSSDFAEHLMEVLDTDSLYFYDAVSPIIYADSINYEKVFSASRYGKGEETYLNCPMTKEEYERFVEELINAETVESHYPGEEKFFEGCLPIEVLAKRGIDTLRYGPMKPIGLIDPKTGKEPYAVVQLRPENIQKTLYSMVGFQTRLKFQEQRRIFRMIPGLENAEFARYGVMHRNTYFYAPKFLKATLQFIKDERVFFAGQLIGVEGYMESAAMGIVAGINAARLYKGKPLIILPPTTMIGALISYVTTKVPVRYYQPMNANWGILLPLDKPIKDKKLRNRLLAERALRDLEDVIRRFAINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2H5</accession>
    <name>B8E2H5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583894.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353433.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1545"/>
    <dbReference type="EnsemblBacteria" id="ACK42819">
        <property type="protein sequence ID" value="ACK42819"/>
        <property type="gene ID" value="Dtur_1545"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1545"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1594"/>
    <dbReference type="eggNOG" id="COG1691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2H5"/>
    <dbReference type="OMA" id="EVIWGPG"/>
    <dbReference type="OrthoDB" id="1744359at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="117"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="252" mass="27482" checksum="CA253B17894163A0" modified="2009-03-03" version="1">MREKLREILEKVKTGEVSIEKAIDELRILPYEDLGYAKVDHLRGVIKGFPEVIFSQGKTTDQVINIMLNLLKINKRVIATRASFELYEKLKEYIPDAIYFDKARIIAVLREDIKKKGKVVVACAGTADLPVAEEAAITAEIMGSNVERIYDVGVAGLHRLIDQLDKFYSSNVVIVVAGMEGALPSVVGGLIAKPIIAVPTSVGYGANFNGLSALLSMLNSCVPGIAVVNIDNGFSAGYLANMINLMVEENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2I5</accession>
    <name>B8E2I5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="2">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="2">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsmG</name>
        <name evidence="3" type="ordered locus">Dtur_1555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the N7 position of a guanine in 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583904.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353443.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1555"/>
    <dbReference type="EnsemblBacteria" id="ACK42829">
        <property type="protein sequence ID" value="ACK42829"/>
        <property type="gene ID" value="Dtur_1555"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1555"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1604"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2I5"/>
    <dbReference type="OMA" id="ICFPHLH"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="2">
        <location>
            <begin position="131"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="240" mass="27980" checksum="FAC7A30D7D69CF9F" modified="2009-03-03" version="1">MEESFKEILKEKVNELNLKLDPLQEEKFYLYYKALKEWNRKINLTSLEGEEEIILKHFVDSLACIIPIKDENIEKIIDIGTGAGFPGIPLKIYNEKYKLTLLESQKKKVLFLEEITKILKLSNVEIIWDRAENLGKNPKYRENFDLALARGVAKPHIVLEYAIPFVKIGGIFLGQATPNNITEWENTKRTIEILGGEIEEKLEVNFDNITRIFLKIRKKNNTPEKYPRRPGIPEKRPLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2I9</accession>
    <name>B8E2I9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock protein Hsp20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1559</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583908.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353447.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1559"/>
    <dbReference type="EnsemblBacteria" id="ACK42833">
        <property type="protein sequence ID" value="ACK42833"/>
        <property type="gene ID" value="Dtur_1559"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1559"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_3_0"/>
    <dbReference type="InParanoid" id="B8E2I9"/>
    <dbReference type="OMA" id="TNRPAVM"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="34"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="133" mass="15608" checksum="F356BD7D8410FA4D" modified="2009-03-03" version="1">MERRRIYMQGNDPFGGQIFRIVDCFYREGSRFSMQWGAWVPRVDVYETDDKIVVLVEIAGVRKEDIDLTFHEGKLILRGTRQEHYVSDPAIYYQMEINFGPFERIIPLPTDVDAEKAEAVYKDGFLEIILPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2L4</accession>
    <name>B8E2L4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583933.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353472.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1585"/>
    <dbReference type="EnsemblBacteria" id="ACK42858">
        <property type="protein sequence ID" value="ACK42858"/>
        <property type="gene ID" value="Dtur_1585"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1585"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591752_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2L4"/>
    <dbReference type="OMA" id="GKWNWDT"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="442" mass="50999" checksum="0F9EAEE760230877" modified="2009-03-03" version="1">MAKSKIFVIFFLVFFAFLTFVPGFGQRVYQYKVGNYVLNIDTQKYRGKTIYVWQHWPEEEKSSIPDVRSPKEAREEFEKITGAKVKIVYVTWETKVEKQTAAILSGSGCDIVYIDSRQKPTWMMKKMLLPLNRYIDFNNKDLYNAVGFRKPILDYFTWRGQIYAVTNIYNDNVFPYILYYNKEKFEMAGLPDPLELYKQGKWTWETFFNLGKQLTQDTNGDGKIDQYAYASWRTYAPFLWTNDVMPIKYVGGRPVFNLDNPKAYKAFQAVYEMDAKYKMRPADWWTDPQGRFQKGITCMDYWGPWDISNMRNALGKKLGMVPFPKGPDTNKKSADEGDDSAWAIASSSKDPELAALYLLWMLMPTDKEKELIVKNQIERVGGKEVYDILMDAATRTVINPAAGIPGFSELMDQIDTANPAKSIKALKPKFEAAINAVLEGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2N1</accession>
    <name>B8E2N1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1602</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583950.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353489.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1602"/>
    <dbReference type="EnsemblBacteria" id="ACK42875">
        <property type="protein sequence ID" value="ACK42875"/>
        <property type="gene ID" value="Dtur_1602"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1602"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1651"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_5_2_0"/>
    <dbReference type="InParanoid" id="B8E2N1"/>
    <dbReference type="OMA" id="HFMIFKP"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="80"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="320"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="461"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="823" mass="96140" checksum="B64A0C26487E2519" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2N8</accession>
    <name>B8E2N8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583957.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353496.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1609"/>
    <dbReference type="EnsemblBacteria" id="ACK42882">
        <property type="protein sequence ID" value="ACK42882"/>
        <property type="gene ID" value="Dtur_1609"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1609"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1658"/>
    <dbReference type="HOGENOM" id="CLU_181383_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2N8"/>
    <dbReference type="OMA" id="FYFPITT"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021320">
        <property type="entry name" value="DUF2905"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36443">
        <property type="entry name" value="PTHR36443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11146">
        <property type="entry name" value="DUF2905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="73" mass="8556" checksum="2F53977CEBCB80EE" modified="2009-03-03" version="1">MSFLGKWLILFGFILILLGLIFVFMDKIPFLGKLPGDIRIERKNFIFYFPLTTSILLSLILTIIINIILRLRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2R2</accession>
    <name>TPIS_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Triosephosphate isomerase</fullName>
            <shortName evidence="1">TIM</shortName>
            <shortName evidence="1">TPI</shortName>
            <ecNumber evidence="1">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpiA</name>
        <name type="ordered locus">Dtur_1133</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583495.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353026.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2R2"/>
    <dbReference type="SMR" id="B8E2R2"/>
    <dbReference type="STRING" id="515635.Dtur_1133"/>
    <dbReference type="EnsemblBacteria" id="ACK42412">
        <property type="protein sequence ID" value="ACK42412"/>
        <property type="gene ID" value="Dtur_1133"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1133"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1170"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_0"/>
    <dbReference type="InParanoid" id="B8E2R2"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
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        <property type="project" value="GO_Central"/>
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        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
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        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
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        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000118002" description="Triosephosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <sequence length="249" mass="28491" checksum="2020451B2E6FEAE1" modified="2009-03-03" version="1">MRRKIIAANWKMYKTCAETESFIKEFKELSKGYEEKEIVICPPFTSLYVANKLLEDTPIKLGAQNMFWEKEGAYTGEISPIMLKDLNCSYVIIGHSERRQYFSETNDMINKKLKSAFEYELIPIFCVGEKWEEREKGKTEEVITEQVKKGLQGLEKEKVEKIVIAYEPVWAIGTGHSAKGEDANEVAKLIRRIISEIYDEEVSQKVRIQYGGSVNPQNIKEFLAQSEIDGALVGGASLKPQSFWDIVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2S2</accession>
    <name>B8E2S2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar-type H+-ATPase subunit H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583504.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353036.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1143"/>
    <dbReference type="EnsemblBacteria" id="ACK42422">
        <property type="protein sequence ID" value="ACK42422"/>
        <property type="gene ID" value="Dtur_1143"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1143"/>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078484_3_2_0"/>
    <dbReference type="InParanoid" id="B8E2S2"/>
    <dbReference type="OMA" id="GAREYAD"/>
    <dbReference type="OrthoDB" id="1602369at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="145" mass="17039" checksum="9895F71FD8C3B7E1" modified="2009-03-03" version="1">MEEIIKTLKELRDILENSPAIPVWDKVLLDKDRLMELIEKLDKSIPEEFYEAKKIVENKEKIINKAYIEAEEIIKQAQKEAEILVSSNNITLEAQKRAEDIIRNAKKEAEEIKKEMDAYIESLLTKVEDLLKKEIELIRKCRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2S8</accession>
    <name>B8E2S8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="9">HTPA synthase</shortName>
            <ecNumber evidence="4 9">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">dapA</name>
        <name evidence="11" type="ordered locus">Dtur_1149</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="4 9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583510.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353042.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1149"/>
    <dbReference type="EnsemblBacteria" id="ACK42428">
        <property type="protein sequence ID" value="ACK42428"/>
        <property type="gene ID" value="Dtur_1149"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1149"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1186"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_0"/>
    <dbReference type="InParanoid" id="B8E2S8"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="9 10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0704">Schiff base</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="9">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="298" mass="32642" checksum="AACD01277E47D85D" modified="2009-03-03" version="1">MVHFGSLITAMITPFDEYGEINWSEVDRIVEKLIEDGSDSILVSGTTGEAPTLSNKEKLALFERVKKVAGDRVKVIAGTTNYCTKESVELTKEAEKIGVDGILATAPYYNKPPQDGLYLHFAKIASETSLPIIVYNIPSRTAVNVLPETLKRLAQDCPNIVGVKEASGDINQIAMIRKLLPHPFLLYSGDDSMTLPLLSVGGDGVISVASHIVGKEIKEMINSYFSGKVEKAAELHLKLLPIFKGLFLTTNPIPLKEALNLLGYNVGKCRLPLSPIDSKNRAELIKILKEYGFQVNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2T4</accession>
    <name>B8E2T4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583516.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353048.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1155"/>
    <dbReference type="EnsemblBacteria" id="ACK42434">
        <property type="protein sequence ID" value="ACK42434"/>
        <property type="gene ID" value="Dtur_1155"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1155"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1192"/>
    <dbReference type="eggNOG" id="COG1079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2T4"/>
    <dbReference type="OMA" id="MIFGNWM"/>
    <dbReference type="OrthoDB" id="1215743at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="308" mass="32890" checksum="27C03BB0079A6653" modified="2009-03-03" version="1">MLESIFAWETIVSAIRMATPLTYASLGGVFSERSGVVNIALEGIMLFGAFFATVGTYFFKSPMVGIIFAILAGMTISLIHAVVSIRFKVNQIISGTALNMLAAGGTTFLSRLIFKAAGSSPHIEGFSPINIPMLSSIPGIGLLFRDLSPLIILMIVLVFFSNYVLYKTVFGLRLRAVGENPQAADTLGVNVYKYRYIGVLISGILGGLGGAFLSLEHARVFVENMTGGRGFIALAAMIFGNWNPVGAFGACLLFGIAEAIRIRLEGVGIPTQFIQMIPYILTMLVLAGAVGKSTPPACDGIPYEKEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2U6</accession>
    <name>B8E2U6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="10">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="10">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gatB</name>
        <name evidence="12" type="ordered locus">Dtur_1167</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="10"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583528.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353060.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1167"/>
    <dbReference type="EnsemblBacteria" id="ACK42446">
        <property type="protein sequence ID" value="ACK42446"/>
        <property type="gene ID" value="Dtur_1167"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1167"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1204"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2U6"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="11">
        <location>
            <begin position="331"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="481" mass="55768" checksum="0D2DF8D238CF8D0C" modified="2009-03-03" version="1">MYKPVIGLEVHAQLSTKTKLFCSCSTEHENLPPNTNVCPICMGFPGTLPVVNKKAVEYAIKAGIALNCEISNYSKFDRKNYFYPDLPKGYQISQYDLPLCRNGYIDLYVDGEIKRIRIKRIHLEEDAGKLLHIGSGDRLSESDYSLVDFNRAGIPLIEIVTEPDINSPKEARLFLQELRLILRYLGISSGDMEKGSLRCDANISIQTEEGKFGTRTEIKNVNSFFSLEKALEYEIERQVEILKRGEEVIQETRHWDEKNQKTISLRSKEEAEDYRYFPEPDLPPLIVTEEMRERLKNEIPELPSKRRERYLNLGLSPIEVEILVSDKDLSEFFDKSLRIYNNPKNLHSWLSVEILSYLNENKIEFKDLEIEPEKFIRLIEMVDKNEITRPVAKEVLKKYLFQKEDPLVIIEKEGLKTVSDTSYLQDVIKRVISNNPKAVEDWKKGKKQVINFLVGQVMRETKGRASLDIVKNLLEEELNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2V5</accession>
    <name>B8E2V5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fimbrial assembly family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583537.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353069.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1176"/>
    <dbReference type="EnsemblBacteria" id="ACK42455">
        <property type="protein sequence ID" value="ACK42455"/>
        <property type="gene ID" value="Dtur_1176"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1176"/>
    <dbReference type="eggNOG" id="COG3166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_590164_0_0_0"/>
    <dbReference type="OMA" id="YLNSAFY"/>
    <dbReference type="OrthoDB" id="2105954at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="462" mass="54195" checksum="FA269C90CFFD1EC7" modified="2009-03-03" version="1">MIGIQWLNGKLRIARISKKGKKVELRDYIEVEIPTGDFWNRGLEEVNLVKERIEKVFRENKIKDKEIVMLFESKDISLRTSEYPYMSIKELEMAILDDLEEYQAFDENYSLFTFSMLDQDKSKIRTTVATIPKVIVNTWESIFKNLGCKLVSFEPSFVSGTRYILWSGKNKYPNGIIFIGNETTDLVFIKEKKINSIINLSVGINDFYNLDELSFDTTFLSWQEELITYLNSAFYELGDKNIVIFGEDERYFKVAENFVKNLSLDYKVDIIENLNISLLGTALYDVNILRINFIKERILIDRELIIRSLISFLLALSLIFPINFYFDLKIRDLDRKINYLQSEILKYNDQISNLRKEVDNQNAMVQILEKWLEERSAVSLPFIFLSDLRYFIPKNVWLTALDIGIDKKLIIEGYSLDTEGVADFLLALSRYERIKSIKLESAILEIMENKEVQKFRVVGYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2W4</accession>
    <name>B8E2W4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prepilin-type N-terminal cleavage/methylation domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583546.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353078.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1185"/>
    <dbReference type="EnsemblBacteria" id="ACK42464">
        <property type="protein sequence ID" value="ACK42464"/>
        <property type="gene ID" value="Dtur_1185"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1185"/>
    <dbReference type="eggNOG" id="COG4966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432466_0_0_0"/>
    <dbReference type="OMA" id="NTINMYR"/>
    <dbReference type="OrthoDB" id="2123745at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="189" mass="22025" checksum="63D77D14C6F2C04B" modified="2009-03-03" version="1">MRKGEKGFTLIETLIVIIIFMIIFSLIFGALLYSFQISRSQQVYDEILDDINIFIQQLSNELRQAYTITFPAYSTYSDNFADFSQNKLIEFNSRDDKNQIRKIIYSFGAPNSKGMREVLYSLNLSTDGGFTYQSVISSQPLTNKVFKNIIIRRPYWDPKVVEVEIFAESLLPYGNTINMYRIFLISLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2X1</accession>
    <name>B8E2X1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-isopropylmalate dehydratase small subunit</fullName>
            <ecNumber evidence="3">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Alpha-IPM isomerase</fullName>
            <shortName evidence="3">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuD</name>
        <name evidence="5" type="ordered locus">Dtur_1192</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the LeuD family. LeuD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353085.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1192"/>
    <dbReference type="EnsemblBacteria" id="ACK42471">
        <property type="protein sequence ID" value="ACK42471"/>
        <property type="gene ID" value="Dtur_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1192"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1229"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081378_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2X1"/>
    <dbReference type="OMA" id="GLPIIEC"/>
    <dbReference type="OrthoDB" id="1384217at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01032">
        <property type="entry name" value="LeuD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011824">
        <property type="entry name" value="LeuD/DmdB_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011827">
        <property type="entry name" value="LeuD_type2/HacB/DmdB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02084">
        <property type="entry name" value="leud"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02087">
        <property type="entry name" value="LEUD_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="4">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="168" mass="18693" checksum="52E74E688FC62A07" modified="2009-03-03" version="1">MMIYKGKALKYGDNIDTDVIIPARYLNTTDPKELAEHCMEDLDLNFKEKVKEKDILVVGENFGCGSSREHAPIAIKASGVKCIIAKSFARIFYRNAINIGLPILEISEAVDRINEGDELEVDFDKGVLKNLTTGETFTTFPFPPLIQEIIKKGGLINFARERVKGGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2X6</accession>
    <name>B8E2X6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="7">DXP reductoisomerase</shortName>
            <ecNumber evidence="7">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">dxr</name>
        <name evidence="11" type="ordered locus">Dtur_1197</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583558.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353090.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1197"/>
    <dbReference type="EnsemblBacteria" id="ACK42476">
        <property type="protein sequence ID" value="ACK42476"/>
        <property type="gene ID" value="Dtur_1197"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1197"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1234"/>
    <dbReference type="eggNOG" id="COG0743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035714_4_0_0"/>
    <dbReference type="InParanoid" id="B8E2X6"/>
    <dbReference type="OMA" id="PIDSEHF"/>
    <dbReference type="OrthoDB" id="1200722at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051484">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway involved in terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
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        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DXP_reductoisom" evidence="8">
        <location>
            <begin position="5"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DXP_redisom_C" evidence="9">
        <location>
            <begin position="138"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DXPR_C" evidence="10">
        <location>
            <begin position="253"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="8"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="379" mass="43390" checksum="9D5126173BB195FC" modified="2009-03-03" version="1">MRKRIIIFGATGSIGTQTLEIIDKNKDKFELIGVASKGNVDKLKAIAEKFKVPYVALFDNKPFSLSYNAKTFYGKEGLEQLANLDSDLVIMSISGIEAVYPLKISIERGANIAIATKEIVVACGDLIKKWLKKSKSKLIPIDSEHSALFQLINSFRKKNIEKIILTASGGPFWNKSREEMEKTKLEEVLKHPTWKMGYKTTIDSANLVNKGLEVIEAHFFFNFDYNSIKVMIHPQSIVHGMIELVDGSIIAQMAYPDMRIPIQYALFYPQRPKIKWSPFDLKNQKLEFYDVDYDKFPALQLAYEVGKKGGVYPAIFAISDEVLVELFIKGIINFKDIVSFIKYALESWKEFKEIENLEQIEYIKNWIKNLIKQKVGYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8E306</accession>
    <name>B8E306_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Binding-protein-dependent transport systems inner membrane component, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353120.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1228"/>
    <dbReference type="EnsemblBacteria" id="ACK42506">
        <property type="protein sequence ID" value="ACK42506"/>
        <property type="gene ID" value="Dtur_1228"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1228"/>
    <dbReference type="HOGENOM" id="CLU_2665228_0_0_0"/>
    <dbReference type="OMA" id="ITSFIWV"/>
    <dbReference type="OrthoDB" id="2155759at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="75" mass="8483" checksum="7B1AE36B6DD0734B" modified="2009-03-03" version="1">MSSIRELLSTSSVVISFIVGFLAAYAVIKEVDFSKIFKNEKSIGAFIGKVILFFFITSFIWVLLSSLFILLRIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E309</accession>
    <name>B8E309_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cof-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583591.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353123.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1231"/>
    <dbReference type="EnsemblBacteria" id="ACK42509">
        <property type="protein sequence ID" value="ACK42509"/>
        <property type="gene ID" value="Dtur_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1231"/>
    <dbReference type="eggNOG" id="COG0561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_0_3_0"/>
    <dbReference type="InParanoid" id="B8E309"/>
    <dbReference type="OMA" id="WTAWLDI"/>
    <dbReference type="OrthoDB" id="1374424at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000150">
        <property type="entry name" value="Cof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00099">
        <property type="entry name" value="Cof-subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="249" mass="28505" checksum="B41C5245D905AAFC" modified="2009-03-03" version="1">MYKLFITDLDGSIMDGSEVISTKNLKAIKILRENNIEITIATGRRWSSISKIVEPLSLTLPVILYNGAGIYDPLRKSFLYLQHLSKEEVIGALKVIHYYLSFVKLGIYHDDKLYEDSEALEFLKDNKNGIIKIFIEGEKELLKELKNRLEKIYLNVVFSSYKYLEILPKGASKGKALKKLLKNLDIKLEEVIALGDYDNDEEMLKLSGLGITLKNASERLKKIADYVIDASPSESVHYIIQQVLNFERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E337</accession>
    <name>B8E337_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoesterase</fullName>
            <ecNumber evidence="2">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1638</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583986.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353525.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1638"/>
    <dbReference type="EnsemblBacteria" id="ACK42911">
        <property type="protein sequence ID" value="ACK42911"/>
        <property type="gene ID" value="Dtur_1638"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1638"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_3_2_0"/>
    <dbReference type="InParanoid" id="B8E337"/>
    <dbReference type="OMA" id="ADTHVPK"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="165" mass="18717" checksum="567895E4805E50F8" modified="2009-03-03" version="1">MVKIGVISDTHLPSRFPYLPQVIVEKLQGVNLIIHAGDWEDIFFLPELQRIAEVVGVHGNMDNFEVKRVLPAKRIITVENVKIGITHGSGAPWGIKERVRNVFEGETLNAIVFGHTHKAVIEWENNILFFNPGSPTDKFFTDKNTIGYLYVDKDKIWGEIVPIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E340</accession>
    <name>B8E340_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="7">4.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ordered locus">Dtur_1641</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="23" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583989.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353528.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1641"/>
    <dbReference type="EnsemblBacteria" id="ACK42914">
        <property type="protein sequence ID" value="ACK42914"/>
        <property type="gene ID" value="Dtur_1641"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1641"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1690"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_0_1_0"/>
    <dbReference type="InParanoid" id="B8E340"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="19">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="20">
        <location>
            <begin position="88"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="21">
        <location>
            <begin position="274"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="18">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ACK42914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="356" mass="40730" checksum="1D5125A199ACB2F4" modified="2009-03-03" version="1">MRELEELRREIDELDRKLLEIINKRAQIVLQIRNWKIKNNYPIFDPSREKELLERLVKENQGPLDEKAIIGIFKTIMSYLRALEKDIEVLYLGPEGSFTHQAAVKFFGEGVKFKPLLLVEDIFKSLEEGSEYAVVPIENSLEGTVGSTMDLLAVTTKKVIGEVYLDVRHSLISSEDSMNKVKRVYSHPQALAQCKRWLRQNLPNVQEIPTSSTSFAAKIVKEEKESAAIASNFAAEVFGLNILAENIQDSWNNKTRFLVLGKDIPKPTGKDKTSIIFSVKHQAGALYRALRPLHDFGLNMTLIQSRPVPAKPFEYRFFVDFQGHIWDEKVSQALERVKEECIDFKILGSYPEANDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E344</accession>
    <name>B8E344_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583993.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353532.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1645"/>
    <dbReference type="EnsemblBacteria" id="ACK42918">
        <property type="protein sequence ID" value="ACK42918"/>
        <property type="gene ID" value="Dtur_1645"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1645"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1694"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_9_1_0"/>
    <dbReference type="InParanoid" id="B8E344"/>
    <dbReference type="OMA" id="GIGLEYC"/>
    <dbReference type="OrthoDB" id="968232at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="233" mass="26443" checksum="42E9C4C465D22EF3" modified="2009-03-03" version="1">MSNYTVFITGASKGLGFSLTKLYLEKGHKVIATYRKNLEKLEEIKNHPNLILYTMDVSDENSVKNAFDFLKDKISHIDILINNAAVYLEDKTKTIENVDIEEAITTLNINSIGPLRVLKYFYSFVERGNKKLIINVSSEAGSISNCWRDREYAYCMSKSALNMLSAILQNYSIPKGIKVLAIHPGWMRTDMGGPNADIAPEEAAEGIYNLSMKDWDISDKNIYMDYKGNLMTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>B8E351</accession>
    <name>B8E351_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ABC-transporter TycD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353539.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42925">
        <property type="protein sequence ID" value="ACK42925"/>
        <property type="gene ID" value="Dtur_1653"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1653"/>
    <dbReference type="HOGENOM" id="CLU_3134989_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="49" mass="5904" checksum="050655B629165856" modified="2009-03-03" version="1">MKKGLMREIFKKDWTLNVLALLLSTVVAFINIYFKNMETDLKRFSLLFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3D6</accession>
    <name>B8E3D6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584085.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353624.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1738"/>
    <dbReference type="EnsemblBacteria" id="ACK43010">
        <property type="protein sequence ID" value="ACK43010"/>
        <property type="gene ID" value="Dtur_1738"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1738"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1790"/>
    <dbReference type="eggNOG" id="COG3507">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1124108_0_0_0"/>
    <dbReference type="InParanoid" id="B8E3D6"/>
    <dbReference type="OMA" id="QINGQPD"/>
    <dbReference type="OrthoDB" id="1622507at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK43010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="249" mass="27527" checksum="85A6F9216D38DCCE" modified="2009-03-03" version="1">MFKKGIVLFVGLLFILLVAGCEKAGEVSLQQIQQIPQKLELPKGLVAYYPFEGDLKDANGLLGEGKVIGPKIGQPGGNVSFADGVVGKALVLDGNSGVLLYEGPVETYEYSIALWIYPEALTYYTPAFFAAINTDTWISIVPGGHSLFEGRAGFWSGSAWFDGWTDMKLETNKWYHFAVTVDNGLVSVYINGEKRFEGKRVQDLFRGEKAIFVLGVNWWDPPFKGKIDELRIYNKVLTADEVKELASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3F2</accession>
    <name>B8E3F2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1754</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584101.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353640.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1754"/>
    <dbReference type="EnsemblBacteria" id="ACK43026">
        <property type="protein sequence ID" value="ACK43026"/>
        <property type="gene ID" value="Dtur_1754"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1754"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1806"/>
    <dbReference type="eggNOG" id="COG1979">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_4_0"/>
    <dbReference type="InParanoid" id="B8E3F2"/>
    <dbReference type="OMA" id="CTMALNG"/>
    <dbReference type="OrthoDB" id="717704at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018455">
        <property type="term" value="F:alcohol dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990362">
        <property type="term" value="F:butanol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990002">
        <property type="term" value="F:methylglyoxal reductase (NADPH-dependent, acetol producing)"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd08187">
        <property type="entry name" value="BDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044731">
        <property type="entry name" value="BDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43633">
        <property type="entry name" value="PTHR43633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="9"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK43026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="385" mass="42795" checksum="81F5B028A4E5B731" modified="2009-03-03" version="1">MRNFVFHNPTKIIFGNDSTNKVGKETKNYGKKVLLITGQGSIKKIGLYDKVVDLLKKEELEIYELSGVKPNPRVDLVREGIKIVRENKIDILLAVGGGSVIDTAKAIAAGLTYEGDVWDLFTKRIPIKPTIPIGVVLTLAATGSEMNGNAVISNMDTQEKLAISSPYLYPKFSILDPQNTVSVPLNHTLYGIVDILSHVFEQYFDRTEDAILQDRFAEAIMRTVIETAPKLAQNPEDLESRAIILWCGTNALNGIIGVGKEQDWASHAIEHAISALYDIPHGLGLAIVFPHWMKYVIDVIPNKFANFARNVWGIQGEDDFEVGLKGIDKLIDFYESLGIPTNLSRIGINNERLEEMAEKATKFGPIGNVKKLNKEDVYKILEMCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYJ7</accession>
    <name>B8DYJ7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carbonic anhydrase/acetyltransferase, isoleucine patch superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582465.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351993.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0041"/>
    <dbReference type="EnsemblBacteria" id="ACK41379">
        <property type="protein sequence ID" value="ACK41379"/>
        <property type="gene ID" value="Dtur_0041"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0041"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_4_1_0"/>
    <dbReference type="InParanoid" id="B8DYJ7"/>
    <dbReference type="OMA" id="YVTIGHN"/>
    <dbReference type="OrthoDB" id="1242595at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="167" mass="18630" checksum="7292CC230E4AC2A1" modified="2009-03-03" version="1">MLKSFDENLPQVDREVYISDRAVIIGKVTLKRGVNIWDFAVIRGDLDSIFIDEYTNIQENVVIHVDEGKPVYIGKYVTIGHSAIIHGCKIEDNTLIGMGAIILDGAVIGRNSIIGAGTLIPQGKEIPEGSVVIGVPGKIVRSVREEEILHIKRNAELYYQLSKKYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYL7</accession>
    <name>B8DYL7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Daunorubicin resistance ABC transporter ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582485.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352013.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0061"/>
    <dbReference type="EnsemblBacteria" id="ACK41399">
        <property type="protein sequence ID" value="ACK41399"/>
        <property type="gene ID" value="Dtur_0061"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0061"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_0"/>
    <dbReference type="InParanoid" id="B8DYL7"/>
    <dbReference type="OMA" id="YNHLLAM"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="338" mass="38639" checksum="B2B6D768577E1ACD" modified="2009-03-03" version="1">MKVIEVKDLAKTYYSPFGNIEAVKGISFEVEEGEIFGFLGPNGAGKSTTIMMLTTLVKPTKGTAKILGYDVVHQPNEVRRVIGYVSQDLTVDDTLTGWENMYLQGRFYHLPKEVIKQRSEELLKLLRLYERAKDKAETYSGGMRKRLDIAMGLIHRPKILFLDEPTLGLDVQTRQDIWEYVQKIRKENGMTIFLTTHYMEEADSLCDRIAIIDKGEIKALDTPRRLKDSIGGDLISLKISNESLEEISKFLEKVKTLEVVKNITSQDGRYTIVASNAEKLIPMIFSIAYESNINISSITMKKPSLDDVYLAYTGKEFRDEEGSKEDAMRMRRLVRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYN5</accession>
    <name>B8DYN5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582503.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352031.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0079"/>
    <dbReference type="EnsemblBacteria" id="ACK41417">
        <property type="protein sequence ID" value="ACK41417"/>
        <property type="gene ID" value="Dtur_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0079"/>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099037_6_1_0"/>
    <dbReference type="InParanoid" id="B8DYN5"/>
    <dbReference type="OMA" id="MVIGYGN"/>
    <dbReference type="OrthoDB" id="1858718at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036211">
        <property type="term" value="P:protein modification process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="140" mass="16452" checksum="B80DB78DCEE9ECC4" modified="2009-03-03" version="1">MKILLVGFGNPYRRDDGLGIKLLDLIEHNVEKIKVQELTFDMAEIFKDYDMVIFIDASLEGNEIVFRRVKEEITFSPLTHHTPCEELLSWTRVLYGKTPEFYLLSIRGYDFDFGEELSEKAKENLKKAEEFLKSFLENHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYN8</accession>
    <name>B8DYN8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular solute-binding protein family 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582506.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352034.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0082"/>
    <dbReference type="EnsemblBacteria" id="ACK41420">
        <property type="protein sequence ID" value="ACK41420"/>
        <property type="gene ID" value="Dtur_0082"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0082"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.83"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_3_0"/>
    <dbReference type="InParanoid" id="B8DYN8"/>
    <dbReference type="OMA" id="RWSDPRM"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002870957" evidence="1">
        <location>
            <begin position="23"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="86"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="636" mass="72929" checksum="C536C5D85C02FCE3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYS5</accession>
    <name>B8DYS5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582542.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352071.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0125"/>
    <dbReference type="EnsemblBacteria" id="ACK41457">
        <property type="protein sequence ID" value="ACK41457"/>
        <property type="gene ID" value="Dtur_0125"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0125"/>
    <dbReference type="HOGENOM" id="CLU_3167353_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="47" mass="5703" checksum="375CA574A4708255" modified="2009-03-03" version="1">MVLVDINSNRYYSLNLVFHKRQEVILVSFSMEFEVKGWLYAIPYYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYS7</accession>
    <name>B8DYS7_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rtcB</name>
        <name evidence="5" type="ordered locus">Dtur_0127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582544.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352073.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0127"/>
    <dbReference type="EnsemblBacteria" id="ACK41459">
        <property type="protein sequence ID" value="ACK41459"/>
        <property type="gene ID" value="Dtur_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0127"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.132"/>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYS7"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="1384936at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003972">
        <property type="term" value="F:RNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000971">
        <property type="term" value="P:tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="207"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="333"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="408"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="486" mass="53782" checksum="FEC8FC0CB2E0F033" modified="2009-03-03" version="1">MSNEWKGKIIKIDDYKFMIPKDYKPFMKVDGIIFADDKLMEDIVKDQSPEQVANVASLPGIIKYSLAMPDIHWGYGFPIGGVAAMKKKGGVISPGGVGYDINCGVRLIRTNLSKEDVMPRLKELVDALFDKIPAGVGSEGDLRVKGKELDEVLEKGAQWAVKQGYGWREDLEHIEERGRLSYADPDKVSKKAKERGEFQLGTLGSGNHFLEVQVVSRIFEPDIADKLGLFPDQVVVMVHTGSRGLGHQVAEDYIRIMKNAMKKYGIEVPDIQLACAPFDSPEGQDYFSAMCAAANFAWANRQMITHWVREVFEEIFRESAESLGMKLIYDVAHNIAKLEEHDIDGKLEEVIVHRKGATRAFPAGHPDLPEAYKEIGQPVIIPGDMGRSSFVLIGLPKAMELAFGSTCHGAGRTQSRSKLLKSGRRAYEIEQELLEKGILVRAASKSSLVEEASEAYKNVVDVVNVVHNAGLSKRVAQMKPIAVIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYS8</accession>
    <name>B8DYS8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycerol-3-phosphate responsive antiterminator, GlpP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582545.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352074.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0128"/>
    <dbReference type="EnsemblBacteria" id="ACK41460">
        <property type="protein sequence ID" value="ACK41460"/>
        <property type="gene ID" value="Dtur_0128"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0128"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.133"/>
    <dbReference type="eggNOG" id="COG1954">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111516_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYS8"/>
    <dbReference type="OMA" id="PAIRNMK"/>
    <dbReference type="OrthoDB" id="1560657at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001072">
        <property type="term" value="F:transcription antitermination factor activity, RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006699">
        <property type="entry name" value="GlpP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35787">
        <property type="entry name" value="PTHR35787"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04309">
        <property type="entry name" value="G3P_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016897">
        <property type="entry name" value="GlpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="195" mass="21527" checksum="1B6203873F9D460E" modified="2009-03-03" version="1">MEKKRLSKEEFLDVLKGNPIIAAVREEERLSQALQSKAKVLFLLKTNVLTLPNVVQEIKSHGKLVFIHLDLLEGLAQDKYALRYLGDVVGIDGVITTRANLIQQAKAEDLIAIQRFFVLDSSALATGVKIMQSAEPDMVEILPGIIFIHLGEELRTQIPYPLIAGGLIRTPEEAREILKAGATAVSTTSVTLWNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYU3</accession>
    <name>B8DYU3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, alpha/beta fold family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582560.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352089.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0144"/>
    <dbReference type="EnsemblBacteria" id="ACK41475">
        <property type="protein sequence ID" value="ACK41475"/>
        <property type="gene ID" value="Dtur_0144"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0144"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775437_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYU3"/>
    <dbReference type="OMA" id="GSGWHSQ"/>
    <dbReference type="OrthoDB" id="1694750at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="57"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="297" mass="34903" checksum="CDBA447B4B28041B" modified="2009-03-03" version="1">MRIKEIFLLFFLLLLSNLFSYDFQSLYKQVKSISDEVFYIHSFDGTKLAYRIAEPKETKYVLIFIHGISLYGRYYYPFLKELSDYGIKVYFLDLRGHGNSEGRRGDSPEEKTFVKDLLLFYNFVKEENKDIPVYLAGHSMGAGLILKLVYHENLKPQGLILISGGLPVEKIHQNNDLLRIKPISKLFSFIAYIFPHFRIIGWDLPEEIDDSLIVNNYSYMFFRSAFPSNIKEIWEKLDLPILSIVGNKDEFYPSEEVLKVYEVYKRTKRKFILLKDSNHIDVIIKSPLYIKEWILGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYV0</accession>
    <name>B8DYV0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="8">ALP N-acyltransferase</shortName>
            <ecNumber evidence="8">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lnt</name>
        <name evidence="10" type="ordered locus">Dtur_0151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582567.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352096.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0151"/>
    <dbReference type="EnsemblBacteria" id="ACK41482">
        <property type="protein sequence ID" value="ACK41482"/>
        <property type="gene ID" value="Dtur_0151"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0151"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_2_0"/>
    <dbReference type="InParanoid" id="B8DYV0"/>
    <dbReference type="OMA" id="IPQSMKW"/>
    <dbReference type="OrthoDB" id="1291198at2"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="9">
        <location>
            <begin position="204"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="475" mass="54753" checksum="83029E5BEA2068CB" modified="2009-03-03" version="1">MDRIRLFFLFIAIILYILSYPPFNISFLIFFTLVPLFSLLPKFSTKEAFIYGFLYGFGFYGVNFYWIPDLVSKFANLGVGIFANLLLISYLSSYYGIFLWGCKKKENSILFPAFFMVLLQWIRSHGPLAFNWGSLGEPMVNILPILQWASVLGELGLSFFVVLVNSLISRWKNLKFIRKTAFALSLVLIFLIGFLMMGESEGKYKVGAVQGNYDSFSKYFYTDIYDQFKVHRDLALKLPDNLDLMVFAESVLFCYLNEYPQYLISLRELSEKKNTPVLIGALEKREDKIYNSAYLITQDGKYITHKKSQLVPFVEEVPFPFNFIIPEYFKGLIGNYNRGPGFTPLPLKEKFIGVLICFESLFSDLARELSQKGSNFLVVITNDGWFEGTPAVYQHRNQSLLRAVENRISLVQVANTGITFFVDPFGRVLKESREGERNVYVANLPKKIFSIYTIWGDLPIFIGFIIFLLIKLIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYW4</accession>
    <name>B8DYW4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Apurinic endonuclease Apn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352204.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0264"/>
    <dbReference type="EnsemblBacteria" id="ACK41590">
        <property type="protein sequence ID" value="ACK41590"/>
        <property type="gene ID" value="Dtur_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0264"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.277"/>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYW4"/>
    <dbReference type="OMA" id="HPGSHLK"/>
    <dbReference type="OrthoDB" id="1088517at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="72"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="287" mass="32662" checksum="CB8F0E79A5847AA8" modified="2009-03-03" version="1">MEYKRLPLYGGASLFKMNKNSYKLGVHLFRGGRSILEDIKLLRINTAQLFSGSPRSYRPTNEKLPVFPFNSVFIHAPYVVNIASPDEKVFNLSIKKVIEELKLAEELEWEGLIIHPGSSKKMGKEVAKRNFFKALEKILEEDIKAKLIVENSAGEGDGWGSTLEDFYSIHEEFPSIYFCIDTCHLFAAGYNLKNPRVCKETFYSFFERIPVEKLVLIHINDSHFPLGSHRDQHAHIGKGAIGIGGFKNLLSIPEIRKIPLILETPKDSPMADLYNLHTIRKILENSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYZ0</accession>
    <name>B8DYZ0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PLDc_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0294</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582701.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352230.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0294"/>
    <dbReference type="EnsemblBacteria" id="ACK41616">
        <property type="protein sequence ID" value="ACK41616"/>
        <property type="gene ID" value="Dtur_0294"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0294"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.310"/>
    <dbReference type="HOGENOM" id="CLU_176001_3_0_0"/>
    <dbReference type="OMA" id="RKNPIIW"/>
    <dbReference type="OrthoDB" id="2063795at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PLDc_N" evidence="7">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="66" mass="7909" checksum="69235FA81DBB2154" modified="2009-03-03" version="1">MEALRQNFPLLLPLFVVQLIFQITAIVDIFKRSKEEIRWENKIIWLIIILVFGFLGPVIYFIFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYZ7</accession>
    <name>B8DYZ7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582708.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352237.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0301"/>
    <dbReference type="EnsemblBacteria" id="ACK41623">
        <property type="protein sequence ID" value="ACK41623"/>
        <property type="gene ID" value="Dtur_0301"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0301"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.317"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053687_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYZ7"/>
    <dbReference type="OMA" id="REWIATP"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="147"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="367" mass="42544" checksum="7A2FD50B7C4AAA7D" modified="2009-03-03" version="1">MERKEEVKIKLEKVRNFLRENDLYAVLIKKQPNFSWITAGGVNFVGMATEMGVTSVLITEKDQFVIANKIEARRMKDEEVEDMFEVLEYEWYEDKEMEIVRTIVGNGKVGCDVLLPDIQFVDDTFKKLRYELTEGEIERYLYLGEKLSRIVEEVLMYETKPGETEIEVAGKISAKLWKEGIEPTAFMIASDDRIRNYRHPISKNKKIEKVVMASVNARYKGLIATMTRMAHFGKIPETLKKQYKDNVEIECIMIAKTKIGEEMRVPVLSAIEEYEKRGYKDEWKLHHQGGSMGYYPRDIRVTPTTTEKIYRNQAFCWNPSITGTKSEDGFITTEKGPIMITKPVIFPTLKIEVEGITFIKPDMLEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ14</accession>
    <name>B8DZ14_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582725.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352254.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0320"/>
    <dbReference type="CAZy" id="GH31">
        <property type="family name" value="Glycoside Hydrolase Family 31"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41640">
        <property type="protein sequence ID" value="ACK41640"/>
        <property type="gene ID" value="Dtur_0320"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0320"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.339"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_10_0_0"/>
    <dbReference type="InParanoid" id="B8DZ14"/>
    <dbReference type="OMA" id="FEIATEH"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="159"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="775" mass="90142" checksum="19073145BA15ECCE" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ17</accession>
    <name>B8DZ17_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582728.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352257.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41643">
        <property type="protein sequence ID" value="ACK41643"/>
        <property type="gene ID" value="Dtur_0326"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0326"/>
    <dbReference type="HOGENOM" id="CLU_1583875_0_0_0"/>
    <dbReference type="OMA" id="TEYFFEF"/>
    <dbReference type="OrthoDB" id="2131845at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="171" mass="20347" checksum="2A2DE75D17DA00B8" modified="2009-03-03" version="1">MEVFVERLLDKGYIDDEEFFVIVTEVDYKDEIPLPKGMFKFQPEFLLNIIEDAVGQNPDLILKVYRALEEKNLYKFNAVFYRSINIVGYDIKVKGQEFSEEEAKSLGLSSDQHNQITGKIEEYVEILKEKLTEYFFEFYKEETEEFVFGEEYIIDLLDDEDEEDDSEDYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ24</accession>
    <name>B8DZ24_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0336</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582735.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352264.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0336"/>
    <dbReference type="EnsemblBacteria" id="ACK41650">
        <property type="protein sequence ID" value="ACK41650"/>
        <property type="gene ID" value="Dtur_0336"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0336"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_6_1_0"/>
    <dbReference type="InParanoid" id="B8DZ24"/>
    <dbReference type="OMA" id="AYNLWIS"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="199" mass="22468" checksum="D5F3420463346CEE" modified="2009-03-03" version="1">MWDKILIILLQFLSGSVMYSYFIAKLLNIDLRKVRDGNPGAYNLWISTNWKIGLIGALLDYLKGIYPLLWFVRYKDIKDKWLITISALAGIFGHVFSPFMEGKGGKGVAVSFGAWTVVTGLEGPLFLGLSMFIFNLAKMRGATPEEDALKVFYGFLCLVPYVIYKVFTGHLYILILYLGNFGIIAYSHRNELLKVFANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZE3</accession>
    <name>B8DZE3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582961.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352490.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0588"/>
    <dbReference type="EnsemblBacteria" id="ACK41876">
        <property type="protein sequence ID" value="ACK41876"/>
        <property type="gene ID" value="Dtur_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0588"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.623"/>
    <dbReference type="eggNOG" id="COG2232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052967_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZE3"/>
    <dbReference type="OMA" id="AYLHAYG"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="116"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="320" mass="36582" checksum="29A47597F7E11647" modified="2009-03-03" version="1">MNILLTSVGRRVSLVKFFKEALNGEGYVYTADCDPTAPGLYVADKSFLVPRVTSEDYIPLLLDKCGKENIKLIIPLIDPELPILAWERDKFLEKGIIPLVSSYERVMIGYDKLLTYEFLVENSFPSPKTFSFDKDLAENKLDFPLIIKPRFGSASIGVQKCENYQDLEFYARKISEPILQEFLQGDEITLDILCDFEGNPISIVQRKRIKVRGGEVERGITIKNYELLYLTLDLVKKLKPFGVINIQCFLTSRGFYFTEINPRFGGGYPLTHYAGVNFPQLIIKLIKGEKVEPIIGEYKEGVLMLRYDEGIFISEEELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZE6</accession>
    <name>B8DZE6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352493.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0591"/>
    <dbReference type="EnsemblBacteria" id="ACK41879">
        <property type="protein sequence ID" value="ACK41879"/>
        <property type="gene ID" value="Dtur_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0591"/>
    <dbReference type="HOGENOM" id="CLU_3288612_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="40" mass="4528" checksum="B0774D92CEF89E50" modified="2009-03-03" version="1">MDAIVIQIAREFGSVLLTLDNEMAEKSKNFVYVGKIEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZG4</accession>
    <name>B8DZG4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR system Cms protein Csm4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0609</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated Csm4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582982.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352511.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0609"/>
    <dbReference type="EnsemblBacteria" id="ACK41897">
        <property type="protein sequence ID" value="ACK41897"/>
        <property type="gene ID" value="Dtur_0609"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0609"/>
    <dbReference type="eggNOG" id="COG1567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062371_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZG4"/>
    <dbReference type="OMA" id="NSKYHFG"/>
    <dbReference type="OrthoDB" id="2044338at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005510">
        <property type="entry name" value="Csm4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040932">
        <property type="entry name" value="Csm4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17953">
        <property type="entry name" value="Csm4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01903">
        <property type="entry name" value="cas5_csm4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Csm4_C" evidence="5">
        <location>
            <begin position="253"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="338" mass="39277" checksum="F53627858F87ECD3" modified="2009-03-03" version="1">MKVEVYKLLKEGPLLLHIGLRRLDRTSNIIHSDTLFSALSNSLIKLFGEEKFDLFEKNLVISSVFPGLRLSKDILLLPKPEIPIKTSEEDHKKYKKFQWISLDALKKLLANFDKNSKQIFIQNVEEFKFLNPRTLITKSEFEEIGEEIYFMGTTLEPKVRVSRETYYKAKADEENSYTTLYFQENLELHPIKLSNRKTIIPFLYFLKMKNNEIEELFTPSLSLTLEEGLGGERTTGKGIFDTFEKEELEVPENGEFEISLSLTFPKREEVNNLIYYQLVKRDGFIYYQKPTGYRKKTHYKIAEGALVRSPYVGENINVSPISSMKVISYGKSLGFKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZG5</accession>
    <name>B8DZG5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRISPR system Cms endoribonuclease Csm3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">CRISPR type III A-associated RAMP protein Csm3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated Csm3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582983.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352512.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0610"/>
    <dbReference type="EnsemblBacteria" id="ACK41898">
        <property type="protein sequence ID" value="ACK41898"/>
        <property type="gene ID" value="Dtur_0610"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0610"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.647"/>
    <dbReference type="eggNOG" id="COG1337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067743_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZG5"/>
    <dbReference type="OMA" id="NPVIKDP"/>
    <dbReference type="OrthoDB" id="1840881at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013412">
        <property type="entry name" value="CRISPR-assoc_RAMP_Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02582">
        <property type="entry name" value="cas7_TM1809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="249" mass="27697" checksum="C8A17E8F932686FC" modified="2009-03-03" version="1">MDKFIGKIFIEGEIVLVTGLHIGGSKETGEIGGLDNPVIKTVEGIPYIPGSSLKGKIRSLLERTYDIKPPKEPGEPCGCGECEICQLFGSHSTENKTISRLIIRDSFLDEEDFQQKFGNALEGGYTEEKVENIIDRIKGTAKDPRIMERVPAGAKFKFSSAISIYEKDDIQKLLMTFVEGMRMLEDDYLGGSGTRGYGQVRFENLNISIKSIKDYLGDNTKKTIIEGKALSEIKMEDLTNKIEDKLSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZJ3</accession>
    <name>B8DZJ3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_0641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583011.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352540.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0641"/>
    <dbReference type="EnsemblBacteria" id="ACK41926">
        <property type="protein sequence ID" value="ACK41926"/>
        <property type="gene ID" value="Dtur_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0641"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_0"/>
    <dbReference type="InParanoid" id="B8DZJ3"/>
    <dbReference type="OMA" id="CDEYRSI"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
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        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
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        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="16"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK41926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="577" mass="65134" checksum="3EE18C4B6AACBDB3" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZM4</accession>
    <name>B8DZM4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="RefSeq" id="YP_002352571.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0672"/>
    <dbReference type="EnsemblBacteria" id="ACK41957">
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    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0672"/>
    <dbReference type="HOGENOM" id="CLU_705421_0_0_0"/>
    <dbReference type="OMA" id="INIVNRY"/>
    <dbReference type="OrthoDB" id="2106553at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="391" mass="45154" checksum="E421600D85055C54" modified="2009-03-03" version="1">MRKVIIGSIALLTVGNIFSQGFDTVPAKSIFIGTEALNYFITYNDSLIYAYQDQIVLLDLNTFKETRLRVKSSKAQDFNTYILKFKLLSNGDVALINNEPYLTIWNPVKNSKIELPFNIEYNKNEKNNLFISQLEIIEDLDISNTAKFIFTKKHITKLFLNFIPIEDHYEYTILSYPEFKKLITLKEINFENAVFSPDDNFLIFKNTKYIEDSNKFYGLTLYDLNKQKEYNLLPNTTVIDFDTTKSAKLLVASTEETGTKIIDLKSLNEISTLPISGYVKFSPLENLLIVEGNRSINIFDIKNKELIATYLGSNSSLSPSQTYMAYALSKNFASLSREILIINRENNEQKRINLKEDYFVEDIQFSKNENFLIIMLSGKDGYKIEIYKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZN2</accession>
    <name>B8DZN2_DICTD</name>
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        <submittedName>
            <fullName evidence="9">Peptidase M42 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352579.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0680"/>
    <dbReference type="EnsemblBacteria" id="ACK41965">
        <property type="protein sequence ID" value="ACK41965"/>
        <property type="gene ID" value="Dtur_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0680"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZN2"/>
    <dbReference type="OMA" id="YTLDNKA"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="336" mass="36936" checksum="3BDB179D8B59ACF4" modified="2009-03-03" version="1">MKELIKKLTEIKSPSGREENIRSAILEELKEYIDGYEIDKLGNLIVWKKGKKEGKILLDAHMDEIGVLATHIDEKGFIRIEPIGGVSPYNLLGSSIAFPNIEGFVGVEGETSEELSKNLKNLDFDKIFVDIGAKNKLEAEKLVPPGTFGVYSASFKDLGERIVSKAMDDRIGCAIIIEVFKKSNPYYTLYGTFSIQEEIGLVGASVVAFNIKPDLAIAVDVTAHSDTPKGPKRMSLELGKGPAIKIKDSASISDRRIVEKLKNIAERNNIPYQIEILLRGGTNAAALQRTGEGIPAGTLSIPTRYVHSPHEMVDIKDVENAVKILKLLVESEESLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZQ9</accession>
    <name>B8DZQ9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YdaE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583077.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352606.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0707"/>
    <dbReference type="EnsemblBacteria" id="ACK41992">
        <property type="protein sequence ID" value="ACK41992"/>
        <property type="gene ID" value="Dtur_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0707"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.745"/>
    <dbReference type="eggNOG" id="COG3822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1553334_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZQ9"/>
    <dbReference type="OMA" id="TFRCRWG"/>
    <dbReference type="OrthoDB" id="1475761at2"/>
    <dbReference type="BRENDA" id="5.3.1.15">
        <property type="organism ID" value="13721"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010864">
        <property type="entry name" value="D-lyxose_isomer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07385">
        <property type="entry name" value="Lyx_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="181" mass="21178" checksum="EBF25AF22D96CA28" modified="2009-03-03" version="1">MKRSEYERAKKRAIEFLERAHIVITDEEKNRIEVADFGLGKIDVFGLQILTYVSTERVCAKELILFPRQTCPEHRHPPFGGDLGKEETFRCRWGKVYLYVPGEPAENPKATVPEEKKKYFTVWHEIELNPGEQYTLYPNIPHWFQAGDEGAIVSEFSTRNSDEYDIFTDPEIRRIPVIEED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZS1</accession>
    <name>ISCS_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine desulfurase IscS</fullName>
            <ecNumber evidence="1">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iscS</name>
        <name type="ordered locus">Dtur_0719</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Forms a heterotetramer with IscU, interacts with other sulfur acceptors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583089.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352618.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZS1"/>
    <dbReference type="SMR" id="B8DZS1"/>
    <dbReference type="STRING" id="515635.Dtur_0719"/>
    <dbReference type="EnsemblBacteria" id="ACK42004">
        <property type="protein sequence ID" value="ACK42004"/>
        <property type="gene ID" value="Dtur_0719"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0719"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.756"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZS1"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017772">
        <property type="entry name" value="Cys_deSase_NifS_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03402">
        <property type="entry name" value="FeS_nifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000119620" description="Cysteine desulfurase IscS">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <note>ligand shared with IscU</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00331"/>
        </source>
    </evidence>
    <sequence length="394" mass="44103" checksum="22FF4BB5E1754DAF" modified="2009-03-03" version="1">MKREVYLDYAATTPLRKEVYEAMKPFLKEKFGNPSSIHHFGRETRTAIEEAREKIAKAIGAKSDEIIFTSGGTESNNMAIKGVAFALSTKGKHIITSKVEHHAVLEPCHFLEKLGFEITYLPVDREGFVDPDDLKKALRKDTILISIMHANNEIGTIEPIQELSKIAKEYDIYFHTDAVQTVGHIPVNVDELGVDLLSISAHKFYGPKGVGALYIRKGTKIHPLIHGGSQENNKRAGTENVAGIIGMGKAIELAILEMDKEIERLTELRDYFIREVEKRISDVYLNGPRSNRLPNNINFSFAYVEGESILLHLDLEGVEVSTGSACSSSSLEPSHVLSAINVPIELAHGSIRFTLGLYTTKEDLNYTLDVLERIIEKLRTISPYKQEWKINKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZS9</accession>
    <name>B8DZS9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methionine synthase</fullName>
            <ecNumber evidence="4">2.1.1.13</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0729</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylamine corrinoid protein family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583097.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352626.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0729"/>
    <dbReference type="EnsemblBacteria" id="ACK42012">
        <property type="protein sequence ID" value="ACK42012"/>
        <property type="gene ID" value="Dtur_0729"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0729"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.768"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082102_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZS9"/>
    <dbReference type="OMA" id="NAMKGGM"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015948">
        <property type="term" value="P:methanogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012741">
        <property type="entry name" value="Corrinoid_p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02370">
        <property type="entry name" value="pyl_corrinoid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="212" mass="22646" checksum="A849F658F8BAD3B8" modified="2009-03-03" version="1">MVDLEEIANAVIAGNRKKVQELVSKTLEKGLNPEEIINNGLLAGMSVIGERFKNNEIFVPEVLVAARAMQAGMDILKPLIAKNSGIIKGKVVIGTVKGDLHDIGKNLVSMMLEGAGYEVIDLGIDVPPEKFVEAIREYNPDIVGMSALLTTTMSYMKVTIDVLEKEGVRRKVKVIVGGAPVTESFAKEIGADGYAPDAPSAVDLVNQLMGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZT2</accession>
    <name>B8DZT2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HcyBio domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583100.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352629.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0732"/>
    <dbReference type="EnsemblBacteria" id="ACK42015">
        <property type="protein sequence ID" value="ACK42015"/>
        <property type="gene ID" value="Dtur_0732"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0732"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.771"/>
    <dbReference type="eggNOG" id="COG1900">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043239_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZT2"/>
    <dbReference type="OMA" id="IRNAYQN"/>
    <dbReference type="OrthoDB" id="390505at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002708">
        <property type="entry name" value="HcyBio"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01837">
        <property type="entry name" value="HcyBio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HcyBio" evidence="1">
        <location>
            <begin position="17"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="407" mass="44617" checksum="93741146554DCDF1" modified="2009-03-03" version="1">MAKTIEEINEKIRQGKAVVVTAEEMIDIVREKGVEKAAKEVDVVTTGTFGIMCSSGIYFNIGHTKPKIKLGGGRVYLNGVPAYAAYAAVDLFLGANALPDDDPRNKYYPGDFEYGGGHVIEDLVSGKEIRITAQAYGTDCYPRKFLDAYITIHDLNEAVLFNIRNAYQNYNVAVNSSDKTIYTYLGMLKPRFGNANYSSAGQLSPLLNDPYYKTIGIGTRIFLGGGIGYVAWHGTQHNPNVERTERGIPKGGAGTLAVIGDLKQMSSEWLRGVSMKGYGVSLAVGIGVPIPILNEEIAFYTSVSDEDILAPVVDYATAYPNRESDVIAYVTYKELRSGEIELFGKKVPTSPLSSYFKARRIAEILKEWIKEGKFLLTSPSAPIPGVESGIKFKPFSGKEVLEEVEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZT5</accession>
    <name>B8DZT5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583103.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352632.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0735"/>
    <dbReference type="EnsemblBacteria" id="ACK42018">
        <property type="protein sequence ID" value="ACK42018"/>
        <property type="gene ID" value="Dtur_0735"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0735"/>
    <dbReference type="eggNOG" id="ENOG5033C8J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132548_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZT5"/>
    <dbReference type="OMA" id="TRKIRIE"/>
    <dbReference type="OrthoDB" id="1774932at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="116" mass="13472" checksum="CE43F9D92F9D0A54" modified="2009-03-03" version="1">MKEERYKILKLVEEGRIKADEAEELIKTLEETSKKEKRYLRVNVIENGKNIVNINVPLSLLKWGLKFANTYAEKYGEKVEISPEEIENLVNDPDFRGKLVDINTPEDNVQVIIEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZU0</accession>
    <name>B8DZU0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583108.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352637.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0741"/>
    <dbReference type="EnsemblBacteria" id="ACK42023">
        <property type="protein sequence ID" value="ACK42023"/>
        <property type="gene ID" value="Dtur_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0741"/>
    <dbReference type="eggNOG" id="COG3842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZU0"/>
    <dbReference type="OMA" id="HLGWEIQ"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055052">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="357" mass="40343" checksum="ED203D04EE5AA1D6" modified="2009-03-03" version="1">MSIEVRLENITKTFKTKNEILYALKNINFKIPPGKTISILGPSGCGKTTLLKIIAGLERPDEGKIFFNNEDVTELSPYERKIGMVFQNYALYPHYKARGNLAFPFWIKKTPEKEIDEKIKETAKILGVGFEYLLDKKPKELSGGEQQRVAIGRCIIRNPSIMLFDEPLSNLDAKLRVITRAQLKRLLVMFNTTSVYVTHDQTEAISIGDLIGIMNNGEIIQIGTYDEIANNPQNAFVASFFGKPSMNLIEVKVINSQIIWRNKGIPLEKPIEDGEYLLGFHGRDVLINPDGDIKGEIYFIDGTPADPSKILHIQLEDNTSIKIEIKSGEIYRCGENISFSLPKRIYLFKKSTGERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZV8</accession>
    <name>B8DZV8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583126.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352655.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0759"/>
    <dbReference type="EnsemblBacteria" id="ACK42041">
        <property type="protein sequence ID" value="ACK42041"/>
        <property type="gene ID" value="Dtur_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0759"/>
    <dbReference type="eggNOG" id="COG3634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082677_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZV8"/>
    <dbReference type="OMA" id="RMAHKFA"/>
    <dbReference type="OrthoDB" id="1300544at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011767">
        <property type="entry name" value="GLR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011903">
        <property type="entry name" value="Glutaredoxin-like_bact/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02187">
        <property type="entry name" value="GlrX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00195">
        <property type="entry name" value="GLUTAREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="1">
        <location>
            <begin position="145"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="227" mass="25807" checksum="A567652F75B96621" modified="2009-03-03" version="1">MALLKEEDRQYLENLFRENLKDKLKIILFSDKAAGSKLVVPGRVECPYCQQTREILEELVSLSDKLELEIHDFLTDEILAKKYNLDKIPAILFEKNNNVLGVRYFGIPSGYEFSSLIEDIIDISRGETQLSPNTKAFLATVDKPVHIQVFVTPTCPYCPRAVRLAHQFAMENPLITADMIEAIEFPHLAEKYDVTGVPKTIINEKVEIEGAVPENVFLEYFKSALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZW8</accession>
    <name>B8DZW8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583136.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352665.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0769"/>
    <dbReference type="EnsemblBacteria" id="ACK42051">
        <property type="protein sequence ID" value="ACK42051"/>
        <property type="gene ID" value="Dtur_0769"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0769"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.806"/>
    <dbReference type="eggNOG" id="COG4986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036171_2_0_0"/>
    <dbReference type="InParanoid" id="B8DZW8"/>
    <dbReference type="OMA" id="FGTQWYI"/>
    <dbReference type="OrthoDB" id="1065003at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="59"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="367"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="570" mass="64501" checksum="4CBA8480035E4FB4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZZ1</accession>
    <name>B8DZZ1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583159.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352688.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0793"/>
    <dbReference type="EnsemblBacteria" id="ACK42074">
        <property type="protein sequence ID" value="ACK42074"/>
        <property type="gene ID" value="Dtur_0793"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0793"/>
    <dbReference type="eggNOG" id="COG2861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709270_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZZ1"/>
    <dbReference type="OMA" id="FIDHEND"/>
    <dbReference type="OrthoDB" id="1927281at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10936">
        <property type="entry name" value="CE4_DAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006837">
        <property type="entry name" value="Divergent_DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30105">
        <property type="entry name" value="PTHR30105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04748">
        <property type="entry name" value="Polysacc_deac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="391" mass="45582" checksum="EE52542FB4B79D62" modified="2009-03-03" version="1">MERKIQKVILLILIFFLLWLGGCGEDRKIEKGEEINKGEVVREKLSLNLDTKIAEEIIKVYEKEIDKYLVEDKNEEFRDYVLGYKVYSIYYKNLMIKYFLLPTLKSENLIIRKVKSSDKLVEKYQVYKKYSLPSGETKDVKILNLYFPISRISGVLPKIAFVVDDVVEDNYWVHELLSFPYTLNISIIPTRKAEKVAEKIFERGWEIMMHLPMESITYPKDAKYLVAEAIMVGMNEDEIDNIVRTHLKRFGNIKVSWVNNHMGSKVTKDPETMEKVINVFKKYNLAFLDSKTILGSVAYKMANSSGIPSLENMLFIDHENDENKIRLRFLKAINMAKSKGWGVFILHLRPKTIKVLKELEKEGFFADVDLVKISDLYEAINEHSLDLPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E014</accession>
    <name>B8E014_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Surface antigen variable number repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583181.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352711.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0816"/>
    <dbReference type="EnsemblBacteria" id="ACK42097">
        <property type="protein sequence ID" value="ACK42097"/>
        <property type="gene ID" value="Dtur_0816"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0816"/>
    <dbReference type="eggNOG" id="COG0729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_559890_0_0_0"/>
    <dbReference type="OMA" id="YELVIHV"/>
    <dbReference type="OrthoDB" id="258122at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POTRA" evidence="1">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="487" mass="56418" checksum="20189440E216EFF2" modified="2009-03-03" version="1">MRKIIAFLIVSIILLGVMYGEENYLIQGIVFDGVKNVPYDILQNTLNIKVFSSYSKDYIEREVQKLKNTGYFRALTYELVKRDVGYELVIHVEELPVISKIIFPDTKLIPIEEIKGILYSKERGFFSEEKAKEDCDKIEKYYIKKGFVLAQSPEYSFKDNILTFNWKELPPIGRIEIKAKGYWEEPLIRNFLKLRIGEYLDMRKIEELNDFFYKKNIKIKVEPEWKIEDENTVLYLNVVYLSPREVSLSYNYNKSIDLKMGYFLGSIGYLETSLSSDLQGNLDYGINLQSYYFDLDINNKGYSIALKRLMSKTNNIEAELGYKGSFVLNDKALFIYFTQDLTKTYKGIPESGRYIRLGLDFHGGGSSYNFSILSFEGKYYLSLGEGLDRKIIGVEGEIGYSFGDLPDGGYLGVRLLYIMPLEYHTYLSLKIGGDSNFSSLSSFSELNFNILGGFCWYSINEPVEYLMNLESDFVRVLNLKLETKIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E044</accession>
    <name>B8E044_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HhH-GPD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583211.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352741.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0846"/>
    <dbReference type="EnsemblBacteria" id="ACK42127">
        <property type="protein sequence ID" value="ACK42127"/>
        <property type="gene ID" value="Dtur_0846"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0846"/>
    <dbReference type="eggNOG" id="COG2231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_6_0_0"/>
    <dbReference type="InParanoid" id="B8E044"/>
    <dbReference type="OMA" id="GPQGWWP"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="35"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="223" mass="26788" checksum="2C2DE16400D642E0" modified="2009-03-03" version="1">MNLIEDIFKVLFDKYGPQYWWPADTPFEVIIGAILTQATNWRNVEKAIRNLKEENLLDPFKLYSLNEEKLSVLIKPVGFYKIKAQRLKNFINYFVKEYHGDLLAMNRNPTRELREELLKIKGLGKETVDSILLYVFNRPVFVIDNYTKRIFSCLGIGSFDLPYEDWQKIFHNSLFPIYQLFQEYHALIVEHGKRSCKKCPNHCFLRRYLFNNRIFYKSRNYFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E045</accession>
    <name>B8E045_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">purH</name>
        <name evidence="10" type="ordered locus">Dtur_0847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583212.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352742.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0847"/>
    <dbReference type="EnsemblBacteria" id="ACK42128">
        <property type="protein sequence ID" value="ACK42128"/>
        <property type="gene ID" value="Dtur_0847"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0847"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.886"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_0"/>
    <dbReference type="InParanoid" id="B8E045"/>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="498" mass="56291" checksum="50BB4E4427EBDE4E" modified="2009-03-03" version="1">MKYALISVWDKTDLEKLCNKIVNLGYGLIATSSTAKYLREYGFKVKETSEITGFSELIGGRVKTLHPKIFAGILARRDNPKDIEDLEKESIPVINIVVCNLYPFQQVIKKENVTLEEALENIDIGGVSLLRAAAKNFPHVLVVPSPKYYEEVIDYLEKGGDDIEFRRKMAIRAFSLTSIYDNIISGYLAQNLEENIALYLTKKLDLRYGENPQQKAGFYMLDDEDPPFIQYQGKELSYNNLLDTDSAWNLIKEFNEPTVAIIKHNNPCGVASDNDTLRAFIKAFEGDPVSAYGGIIACNFEVGEDLAKEVIKHFFEVIVAPSYKEEALKIFSQKKNLRVLRYREDILENPFEIRSLRRGFLIQTFNRILFDNHEVKTSHKPTEKDIEELIFALKVVKHVKSNAIVVSKEKQTLGIGAGQMNRVNSVKIALEQAGEKAKGAYLASDAFFPFPDSIEIAAKYGIKAIIQPGGSIRDNEVIEAAERHGIILVMISSRHFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E073</accession>
    <name>B8E073_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0875</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583240.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352770.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0875"/>
    <dbReference type="EnsemblBacteria" id="ACK42156">
        <property type="protein sequence ID" value="ACK42156"/>
        <property type="gene ID" value="Dtur_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0875"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.913"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_2_1_0"/>
    <dbReference type="InParanoid" id="B8E073"/>
    <dbReference type="OMA" id="TRQMATM"/>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="75"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="10">
        <location>
            <begin position="278"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="409" mass="45257" checksum="4CAB0F04A5285721" modified="2009-03-03" version="1">MAKVYVYQARNMKGELITGEYEAENIREVAIRLRGMNLYPVRIEEKRTPSSFFSLTLAPKKEKVGKVKLTDLTVFTRQFATMINAGLSLSTCLNILSEQSESKALRQILKEIQRMVDEGSSLSEAFAKFPNVFSPLYINMVKAAESAGTLDETLERLAVTLEKQQELRRKIKSAMTYPVIVLIIAIGAGFGMLTFLVPIFAGMFESMGAQLPLPTLVLLKMSKFITSNILLILLGTIILILGAIRAWKNPKIKDKIDEILLKIPVFGGLIQKTSVVNFATTLAAQVRTGVPILQALQLAGQTAGNSVFRKAIDLTRQRVREGERIAPVLKETKVFPPMVVHMISIGEESGSLEQMLNKIAEFYEGEVAAAVESLTSLIEPLMMVFVGGIVGGMLIALYLPIFTMFQYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E074</accession>
    <name>B8E074_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0876</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583241.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352771.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0876"/>
    <dbReference type="EnsemblBacteria" id="ACK42157">
        <property type="protein sequence ID" value="ACK42157"/>
        <property type="gene ID" value="Dtur_0876"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0876"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_5_0"/>
    <dbReference type="InParanoid" id="B8E074"/>
    <dbReference type="OMA" id="CGVNTAK"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="30"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="235" mass="27744" checksum="F1CC6BB2E72E33DA" modified="2009-03-03" version="1">MIRPALDLWLKYKETGDKKFLEELLNVFDDLIHYWASKFTSYGEPLEDLIQIGYLGFLKAIENYDPKKGELSTYISHYVLGEIRHHLRDKIDKIKIPRSVKILINKMDNFIKEVWEKENRSPSCEEIAKHLNITVESVDELFKIKEAMMTVSIEDLEIEVDRIRTERLESFKLPIEEKIALEQAISKLPEIQKKIIEYIFYQDLTQTEVAKILKISQTQVSRLLKSALEKLREML</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E093</accession>
    <name>B8E093_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_1260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353152.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1260"/>
    <dbReference type="EnsemblBacteria" id="ACK42538">
        <property type="protein sequence ID" value="ACK42538"/>
        <property type="gene ID" value="Dtur_1260"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1260"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1300"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_10_0_0"/>
    <dbReference type="InParanoid" id="B8E093"/>
    <dbReference type="OMA" id="GDDVMLY"/>
    <dbReference type="OrthoDB" id="1639008at2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00199"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010493">
        <property type="entry name" value="Ser_AcTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06426">
        <property type="entry name" value="SATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SATase_N" evidence="10">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="240" mass="26649" checksum="221754898833CEAB" modified="2009-03-03" version="1">MLFLYQRSINWGEKVMKKIIETIIADYKAVFEKDPAARNFLEVILCYPGFHAILLHRIAHFLWKLKIPIIPRLISHINRFLTGIEIHPGAKIGKGFFIDHGMGVVIGETTEIGDNVLIYQGVTLGGTGKEKGKRHPTIGNNVVIGAGAKVLGPITIGDNTRIGAGSVVLKSVPPNCTVVGVPGRIVTQEGKKLTPKEMLEHGNIPDPELRLIEELNAKIENLEKRINYLENLIREKIKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0C5</accession>
    <name>B8E0C5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M78 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583652.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353184.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1293"/>
    <dbReference type="EnsemblBacteria" id="ACK42570">
        <property type="protein sequence ID" value="ACK42570"/>
        <property type="gene ID" value="Dtur_1293"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1293"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1336"/>
    <dbReference type="eggNOG" id="COG2856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134323_0_0_0"/>
    <dbReference type="OrthoDB" id="1840229at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M78" evidence="1">
        <location>
            <begin position="35"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="143" mass="17047" checksum="813EA66347FC65E1" modified="2009-03-03" version="1">MLSNLLEMVEEEGIHLEWWDFKEPISAVYLEMEGVKVIGLRRDINRSKKEFKCALAEELGHYFTGSTYSDRKPENYREEIEISRKEYRAMKWKVSYLIPEEEFLEAVRKGITEVWQLAEYFDLPEELIKFYLKLPKVQESLGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0F9</accession>
    <name>RS21_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsU</name>
        <name type="ordered locus">Dtur_1330</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012547397.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353218.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0F9"/>
    <dbReference type="SMR" id="B8E0F9"/>
    <dbReference type="STRING" id="515635.Dtur_1330"/>
    <dbReference type="EnsemblBacteria" id="ACK42604">
        <property type="protein sequence ID" value="ACK42604"/>
        <property type="gene ID" value="Dtur_1330"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1330"/>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159258_3_1_0"/>
    <dbReference type="InParanoid" id="B8E0F9"/>
    <dbReference type="OMA" id="FKRSCQK"/>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000120611" description="30S ribosomal protein S21">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <sequence length="56" mass="6706" checksum="3ED403259BB7015C" modified="2009-03-03" version="1">MTEVRVGKDESLDSALKRFKKKLQEDGVLADIRRHEYYEKPSEKRNRKKAQSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0I5</accession>
    <name>B8E0I5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MglA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583711.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353244.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1356"/>
    <dbReference type="EnsemblBacteria" id="ACK42630">
        <property type="protein sequence ID" value="ACK42630"/>
        <property type="gene ID" value="Dtur_1356"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1356"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1401"/>
    <dbReference type="eggNOG" id="COG1100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077110_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0I5"/>
    <dbReference type="OMA" id="MSTINFA"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="PTHR11711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="195" mass="22029" checksum="B7E54626DC4F0F2E" modified="2009-03-03" version="1">MAVLNYAAREITCKIVYCGPGLSGKTVNLQQIYKMVSPDRRGELVSLATETERTLFFDFLPLDLGTVQGFKLRFQLYTTPGQALYEASRKLILRGVDGLVFVVDSQKSRLDENVRIFEALKKELAAVGYDFNTLPFVFQYNKRDLPDIVSVEELNQKLNPDGKYKYFEAVAIEGKGVMETLKAISQEVLLKLTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0N0</accession>
    <name>B8E0N0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012548709.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353664.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1778"/>
    <dbReference type="EnsemblBacteria" id="ACK43050">
        <property type="protein sequence ID" value="ACK43050"/>
        <property type="gene ID" value="Dtur_1778"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1778"/>
    <dbReference type="HOGENOM" id="CLU_2933955_0_0_0"/>
    <dbReference type="OrthoDB" id="2159405at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK43050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="60" mass="7236" checksum="4DB7F65FA586D6BD" modified="2009-03-03" version="1">MRKPEEIRQLIQELSDYKHSKLLDSFGPEYIRRETAQRIISVLRWVLEDPAVQINLKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0N3</accession>
    <name>B8E0N3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Argininosuccinate lyase</fullName>
            <shortName evidence="5">ASAL</shortName>
            <ecNumber evidence="3 5">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argH</name>
        <name evidence="8" type="ordered locus">Dtur_1781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="3 5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584127.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353667.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1781"/>
    <dbReference type="EnsemblBacteria" id="ACK43053">
        <property type="protein sequence ID" value="ACK43053"/>
        <property type="gene ID" value="Dtur_1781"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1781"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1833"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_0"/>
    <dbReference type="InParanoid" id="B8E0N3"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="OrthoDB" id="751464at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="6">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ASL_C2" evidence="7">
        <location>
            <begin position="362"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK43053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="479" mass="55653" checksum="3EBBE8B94A7E0254" modified="2009-03-03" version="1">MALWGSRWRKPLDKTVEDFTYSLDFDKRLWKADLTGTLAHVIMLNKIGVISEEELKTLKKEIKNLYLEILNNPDLIRDSEDVHTFIEENLTKKIGDIGKKIHTGRSRNDQVVLDLRLYLKEEACNIAELLIDLRKVLFDLSEKFINVPMPGYTHLQQAQPVTLAHYFLAYDAMFSRDLERLEDIYKRIDVMPLGSGALAGSNIPLDREYTAKLLRFSKISDNSMDAVSDRDFVLEFLFFSALVYTHLSRLAEEIILWSTKEFSFIRLPEEYSTGSSMMPQKRNPDVAELTRGKTGKVIGNLVNMFTVVKGLPLSYNRDLQEDKPSLFSSVDELKITLKVWTGFLSHIEFNIDGMYRFSSEDFLFATDIAEYLVLKGMPFREAHKVVGEIVRFCEENNKKFRDLSLEDWRRFSDLFDESVFSLLTPESSLKFKKTYGSPNPDINREVIKKRREEMKNTIEKWNILRNNLPDLAKLLEGLY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0N9</accession>
    <name>ASSY_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate synthase</fullName>
            <ecNumber evidence="1">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argG</name>
        <name type="ordered locus">Dtur_1787</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584133.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353673.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0N9"/>
    <dbReference type="SMR" id="B8E0N9"/>
    <dbReference type="STRING" id="515635.Dtur_1787"/>
    <dbReference type="EnsemblBacteria" id="ACK43059">
        <property type="protein sequence ID" value="ACK43059"/>
        <property type="gene ID" value="Dtur_1787"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1787"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1839"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_0"/>
    <dbReference type="InParanoid" id="B8E0N9"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="OrthoDB" id="357142at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000191893" description="Argininosuccinate synthase">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <sequence length="397" mass="44986" checksum="2883E3E95625C03B" modified="2009-03-03" version="1">MEREKVVLAYSGGLDTSVAIKWLMQKYSLDVITLTVDIGQGIDLNEIKNKAENLGVEKAYVLDLREEFIKDYIIPAIKSNAMYERVYPLATALSRPLIAKYLVKVAKENGAKYVAHGCTGKGNDQVRIDLGVKALAPDLEIIAPVREWNFSREEEIEYAIENNIPIPVSRKNPYSIDENLWGRSIEGGILEDPWQEPPEDIYLWTKLENKEPSYIEITFEKGIPVKLNGVEKDLVGLIEELNKIAGSYGIGRIDHIENRLVGIKSREIYEAPAALVIIKAHEALEDLVLPRELAHFKRMLEDKYAELVYYGLWFDPFREALQAFMDKTQERVTGKVKIKLIPWSFSIVGRDSPYSLYDHSLATYDKGSTFSTESAVGFIKLFGLQNYLYALKGGKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Q8</accession>
    <name>B8E0Q8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584152.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353692.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1807"/>
    <dbReference type="EnsemblBacteria" id="ACK43078">
        <property type="protein sequence ID" value="ACK43078"/>
        <property type="gene ID" value="Dtur_1807"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1807"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1859"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0Q8"/>
    <dbReference type="OMA" id="LTMTNGQ"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="295" mass="33291" checksum="21A905EF69267B0B" modified="2009-03-03" version="1">MQKDKILSFLFILPSLILVIIFVYIFIGWTGFISLTDWNDIFPSYNLVGFRNYLELFQNLRFQISMRNTLVFTTLFLLASLIIGFLLAIFLDQRIRGENLFRNIYLFPMAISFVVTGVVWRWILNPGTAGNPVGLNQLLDKIGLSFLKSGWYTDPKIGIKAVVIAAVWQMSGYVMAMYLAGIRSIPYELFEAAQVDGANLWQVYRYIVLPLLRPITLGAVIILGHISLKIFDLVVAMTGAGAGFSCDVPALFMYDTTFRGNHFAQGASIAIILLVMVGVLIVPYLRYSLRSEVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0U1</accession>
    <name>B8E0U1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mreB</name>
        <name evidence="3" type="ordered locus">Dtur_1404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583756.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353292.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1404"/>
    <dbReference type="EnsemblBacteria" id="ACK42678">
        <property type="protein sequence ID" value="ACK42678"/>
        <property type="gene ID" value="Dtur_1404"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1404"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1451"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0U1"/>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="348" mass="37821" checksum="F31E7EA9B9DB0C7D" modified="2009-03-03" version="1">MAFNFLSGLFSKDLGIDLGTANTVVYVRGKGIVAFEPSMVAIRRSDKKVVAVGEEAKRMLGRTPEEIITIRPLKDGVIADFDAAEKMIRYFIDKVHNKRDFLVSPRMVIGIPSGTTPVERRAVIDTAYSAGARDVLLVTEPIASALGADLPIWEPSGNIIVDIGGGTTEIAVISLGGIVVSTSIKVAGDEMDEAIIHYIKKKYNLFIGERTAEEIKIKLGNVAFGEEKKEYIEVKGRDLLTGVPRNVELSSEEIRDALKDTVDIIVESIRETLEKTPPELAADIIDKGIVLAGGGALLRGLDTYISEQIGVSTIVAEEPLLCVVKGTGKIIEEFERYKQVLSNASENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0X1</accession>
    <name>B8E0X1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">Dtur_1434</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583786.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353322.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1434"/>
    <dbReference type="EnsemblBacteria" id="ACK42708">
        <property type="protein sequence ID" value="ACK42708"/>
        <property type="gene ID" value="Dtur_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1434"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1481"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_0"/>
    <dbReference type="InParanoid" id="B8E0X1"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044262">
        <property type="term" value="P:cellular carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACK42708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="220" mass="24782" checksum="F4548941409F2133" modified="2009-03-03" version="1">MEIKVYPSLLSADLLNMERSIEIVKDLSDALHVDIMDGHFVPNLSYGPSLVKALRNRYSIPLNVHLMVEKPENFVDMFIEAGASHLGFHVEATHHPQRLLKYIRDHNIRPFITLNPATPLNTIEYLLGELDMVLIMTVNPGYGGQEFLHFSLKKIKSLREMAVKEGINLDIMVDGGIDLHTAPLVIEAGANVLISGNSIFNSENPREVIIKMKSIRYKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Y0</accession>
    <name>B8E0Y0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ordered locus">Dtur_1443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583795.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353331.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1443"/>
    <dbReference type="EnsemblBacteria" id="ACK42717">
        <property type="protein sequence ID" value="ACK42717"/>
        <property type="gene ID" value="Dtur_1443"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1443"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1490"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_2_0"/>
    <dbReference type="InParanoid" id="B8E0Y0"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="OrthoDB" id="1502854at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK42717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="210" mass="24310" checksum="55C57CFAED465416" modified="2009-03-03" version="1">MFRGNLFVLSGPSGVGKDAILERVLRIVPNLVKSISYTTRPKRPGEEDGKNYFFVNEEKFKEMIDKEEFLEWAVVHGYLYGTPKKMVEDYISKGVDVILKIDVQGGINVKRIFSDAKLVFVLPPDFNELKRRLINRETEDLQDLNIRLKNAPLEISKISYYDYAVVNDNLDEAVDVVRCIIYAERHRLCKEKVEHFLRIFGGVKDEGSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Y7</accession>
    <name>B8E0Y7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583802.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353338.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1450"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42724">
        <property type="protein sequence ID" value="ACK42724"/>
        <property type="gene ID" value="Dtur_1450"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1450"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_14_4_0"/>
    <dbReference type="InParanoid" id="B8E0Y7"/>
    <dbReference type="OMA" id="RMIDIFY"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="185"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="411" mass="47400" checksum="93AD8B4697CDB667" modified="2009-03-03" version="1">MIRNYLDKINVAFLSTYPPRACGLATFTEDLIKEIDKIAPLYNPYVDTSVIAVSDDKYTYDTKVIKEINQFNKVDYFELAQYLNDSDIDLLVIQHEYGIFGGESGEYLLDLIYHLKIPFITVLHTVLINPSDKQKYVLKEIGKYSTRVVTMAKNTIELLENIYDIDRRKIVHIPHGVPYIYYGERENLKKELGLEGKIVVSTFGLIGPGKGLEYGIEAIAKLKNEFPNIVYLILGRTHPGIVKNEGESYREKLLKMVENLGVKENVLFVNRYLTQEEILKYLQASDIYMTPYLNKEQAVSGTLSYALSCGRVIVSTAYRYAEELLADGRGILVEFRDSEGIYRAIRDVLNNEEKRKEIERKAFKYGKSMWWNVVAEKYITLFHEVILEKNAEIGGWKKWSFSTLELTTYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E118</accession>
    <name>B8E118_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP:guanido phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATP:guanido phosphotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583833.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353369.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1481"/>
    <dbReference type="EnsemblBacteria" id="ACK42755">
        <property type="protein sequence ID" value="ACK42755"/>
        <property type="gene ID" value="Dtur_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1481"/>
    <dbReference type="eggNOG" id="COG3869">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066591_1_0_0"/>
    <dbReference type="InParanoid" id="B8E118"/>
    <dbReference type="OMA" id="SHFNHIE"/>
    <dbReference type="OrthoDB" id="904915at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004111">
        <property type="term" value="F:creatine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046314">
        <property type="term" value="P:phosphocreatine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07930">
        <property type="entry name" value="bacterial_phosphagen_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023660">
        <property type="entry name" value="Arg_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000749">
        <property type="entry name" value="ATP-guanido_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022414">
        <property type="entry name" value="ATP-guanido_PTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11547">
        <property type="entry name" value="PTHR11547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00217">
        <property type="entry name" value="ATP-gua_Ptrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51510">
        <property type="entry name" value="PHOSPHAGEN_KINASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphagen kinase C-terminal" evidence="6">
        <location>
            <begin position="22"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="25"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="173"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="204"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="356" mass="41343" checksum="C28A56F0614EFDF1" modified="2009-03-03" version="1">MREFYYKYLKWLGEEKGNNREVILSTRIRLARNLEDFVFPIQATESQRRRILNKVEWVYKNDLNFGGYEFLKLEKLPNLVLESLVEKHLISDDHLDNIKGAGLLVDRDGKLSVMINEEDHFRLQVLSSGLELKESWQRLLSLEESFSDYFKFAFDDKLGYLTSCITNLGCGVRISFIVHLPGLTYSGKIKDFLRKLRSAKILIRGIYGERSKPIAGFYQITSRSSLGIKEEDLIEKMEKMAKKIITEELVTREFLFEEQKRYVEDVIGRAYGILSNARYLSSIEAINLLSDLRFGIYLKMLDIPLKVLDLLMILMLPAHLQLKYGKEMDSEERDGVRADLLRGFLKNYKINPGGVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E120</accession>
    <name>PDXT_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase subunit PdxT</fullName>
            <ecNumber evidence="1">4.3.3.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pdx2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pyridoxal 5'-phosphate synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxT</name>
        <name type="ordered locus">Dtur_1483</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583835.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353371.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E120"/>
    <dbReference type="SMR" id="B8E120"/>
    <dbReference type="STRING" id="515635.Dtur_1483"/>
    <dbReference type="MEROPS" id="C26.A32"/>
    <dbReference type="EnsemblBacteria" id="ACK42757">
        <property type="protein sequence ID" value="ACK42757"/>
        <property type="gene ID" value="Dtur_1483"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1483"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1532"/>
    <dbReference type="eggNOG" id="COG0311">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069674_2_0_0"/>
    <dbReference type="InParanoid" id="B8E120"/>
    <dbReference type="OMA" id="VFIRAPI"/>
    <dbReference type="OrthoDB" id="1628378at2"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006543">
        <property type="term" value="P:glutamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PTHR31559"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000185887" description="Pyridoxal 5'-phosphate synthase subunit PdxT">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="135"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01615"/>
        </source>
    </evidence>
    <sequence length="190" mass="21578" checksum="13A992F0ABD0BB96" modified="2009-03-03" version="1">MRIGILAIQGSVVEHEKMLKRLEVETVLVKKPEHLDIINGIILPGGESTTFFTLLENRLLFDVLREKLANGLPAMGTCAGLILLANRIENHPDQKTLKVLDITVSRNAYGRQRESFSTYIKIPILGEKEFECVFIRAPQIVEIGKNVKVHATFENKPIFVEEGNILGLTFHPELTDDLRIHEYFLKRCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E167</accession>
    <name>B8E167_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DRTGG domain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583279.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352809.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0914"/>
    <dbReference type="EnsemblBacteria" id="ACK42195">
        <property type="protein sequence ID" value="ACK42195"/>
        <property type="gene ID" value="Dtur_0914"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0914"/>
    <dbReference type="eggNOG" id="COG4109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140224_0_0_0"/>
    <dbReference type="OMA" id="NWDANIK"/>
    <dbReference type="OrthoDB" id="1858096at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpr_kinase_N" evidence="1">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="130" mass="14382" checksum="7933C57D957B0D5E" modified="2009-03-03" version="1">MKGRRLVELIEGKALVGEEKLDEIGIKRAFAADLMSDVLAMVTSEERDVVLITGITNSQIVRTAEILDIPMIIVCRGKVVPKDVIDLAKEKGIILVSTEKIVFEVSGILYSHGIESAVMKKKVKEEYKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E194</accession>
    <name>B8E194_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ordered locus">Dtur_0941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583306.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352836.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0941"/>
    <dbReference type="EnsemblBacteria" id="ACK42222">
        <property type="protein sequence ID" value="ACK42222"/>
        <property type="gene ID" value="Dtur_0941"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0941"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.978"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_0"/>
    <dbReference type="InParanoid" id="B8E194"/>
    <dbReference type="OMA" id="WGSEGDK"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="106"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="236"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="253"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="328" mass="35208" checksum="C9421AF584245F01" modified="2009-03-03" version="1">MGVGIIGIGTAVPSRVLTNFDLEKMVDTSDEWITTRTGIKERRIADNKTTPSDLGAEAALKAIEMAKISPEEIDLIIVTSASLEMVFPSMAAIIQNKIGAKNAGGFDLLSACTGFVSSVITGAQFIRTGDVKTVLVIGTEVLSRFIDWEDRNTCVLFGDGAGAVILREVGDNYGLLSWSLHLDGSGADLLAIPGGCAKYPCSEEVLKNKLHYIKMNGREVFKFSVRVIGEVTEEALSKAGLSSKDLNWLVPHQANIRIIEAGAERLGIPLDKVAINLQKYGNTSTASIPLALEELIKEKKLKDGDIVALVGFGAGLSWGSAVMRWKEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1A7</accession>
    <name>PRMA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="1">L11 Mtase</shortName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmA</name>
        <name type="ordered locus">Dtur_0954</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583319.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352849.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1A7"/>
    <dbReference type="SMR" id="B8E1A7"/>
    <dbReference type="STRING" id="515635.Dtur_0954"/>
    <dbReference type="EnsemblBacteria" id="ACK42235">
        <property type="protein sequence ID" value="ACK42235"/>
        <property type="gene ID" value="Dtur_0954"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0954"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.991"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049382_0_1_0"/>
    <dbReference type="InParanoid" id="B8E1A7"/>
    <dbReference type="OMA" id="EFFFIFP"/>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000192619" description="Ribosomal protein L11 methyltransferase">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <sequence length="299" mass="34410" checksum="67D38AE687D437F8" modified="2009-03-03" version="1">MEYFELMFKTAKELEESIVAILEDVDSIGIAIEDNFFDESILWDYIDKSFSERNYILIKAYFDRNVDIDRIIDKIRTKIKEIFGEAKVEIEYRIIREEDWTNKWKKYAKPIYLDRIVVLPSWEEIGNVEDRILIRIDPGMAFGTGNHPTTIMCIEMLQKYLKEGMDVLDVGTGSGILSIVAKKLGGDKVKGVDIDEKAIEVAKKNAEGNHVEVEFQKNDLIDGINEKYDIVVANLIAEIILKLNANVKRVLKTDGIYIVSGIVQEKLDMILNSLRESGFKLLEVKEKEDWYTVVAQNED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1C0</accession>
    <name>SYDND_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="1">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aspS</name>
        <name type="ordered locus">Dtur_0968</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583332.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352862.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1C0"/>
    <dbReference type="SMR" id="B8E1C0"/>
    <dbReference type="STRING" id="515635.Dtur_0968"/>
    <dbReference type="PRIDE" id="B8E1C0"/>
    <dbReference type="EnsemblBacteria" id="ACK42248">
        <property type="protein sequence ID" value="ACK42248"/>
        <property type="gene ID" value="Dtur_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0968"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1005"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_0"/>
    <dbReference type="InParanoid" id="B8E1C0"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000198981" description="Aspartate--tRNA(Asp/Asn) ligase">
        <location>
            <begin position="1"/>
            <end position="592"/>
        </location>
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        <location>
            <begin position="199"/>
            <end position="202"/>
        </location>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="221"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
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        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="447"/>
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        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="1">
        <location>
            <position position="488"/>
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        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
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        <location>
            <begin position="533"/>
            <end position="536"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="site" description="Important for tRNA non-discrimination" evidence="1">
        <location>
            <position position="31"/>
        </location>
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    <feature type="site" description="Important for tRNA non-discrimination" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <sequence length="592" mass="68344" checksum="5A73BD83E2AD8BC1" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1C3</accession>
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        <submittedName>
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        <name evidence="5" type="ordered locus">Dtur_0971</name>
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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            <taxon>Bacteria</taxon>
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            <taxon>Dictyoglomaceae</taxon>
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    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
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    <dbReference type="eggNOG" id="COG0317">
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
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        <location>
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            <end position="145"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51880"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="ACK42251.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="727" mass="84498" checksum="D4AB98A580A428F7" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1D0</accession>
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        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
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        <name evidence="6" type="primary">fusA</name>
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
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                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
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                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="ACK42258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0978"/>
    <dbReference type="EnsemblBacteria" id="ACK42258">
        <property type="protein sequence ID" value="ACK42258"/>
        <property type="gene ID" value="Dtur_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0978"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1015"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_0"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
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    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
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        <property type="entry name" value="EFTu-like_2"/>
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        <property type="entry name" value="G_TR_CS"/>
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    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
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    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
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        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
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        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="7"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="80"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="691" mass="77655" checksum="FADCCC6A5DD1DC44" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1F2</accession>
    <name>B8E1F2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ordered locus">Dtur_1000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583364.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352894.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1000"/>
    <dbReference type="EnsemblBacteria" id="ACK42280">
        <property type="protein sequence ID" value="ACK42280"/>
        <property type="gene ID" value="Dtur_1000"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1000"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1037"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_2_0"/>
    <dbReference type="InParanoid" id="B8E1F2"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031522">
        <property type="term" value="C:cell envelope Sec protein transport complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005048">
        <property type="term" value="F:signal sequence binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
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    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK42280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="419" mass="46512" checksum="BB56EE8F4871B506" modified="2009-03-03" version="1">MFDTLVRAFRIPDLRKKILFTLFIFAVYRLGAHIPVPGVDRVALANLFRSQGALGFLDLFTGGALSRFSIFSMGIIPFINASIMMELLTAVFPSLAELKKEEDGRKKLTRYARNLSVLLAAIEAFGLTIFMHNFKVIPSLSPLYVISSVITLTAGSTFIMWLGEQISQYGIGNGVSLLILTSIVARFPTDLARTFALLSRGEIGILNVIAFFALLILIIIGVVWEESAERRIPVQYSRRIVGRRVYGGQSTYLPLKLNQAGVIPIIFAITILMVPQTFIPVAKVSWLKAILGIFSPNSVLYPIIYFLLVLGFTYFYSSIVFDPADLAENFKKYGGFIPGVRPGKPTEEYLAKTLNRLNFFGGVFLGIIALLPTFIERLTGVTEFQLGGTSILIMVGVILETIKTLEAQMIMKSYEGFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1G8</accession>
    <name>B8E1G8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMMECR1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583379.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352910.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1016"/>
    <dbReference type="EnsemblBacteria" id="ACK42296">
        <property type="protein sequence ID" value="ACK42296"/>
        <property type="gene ID" value="Dtur_1016"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1016"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1053"/>
    <dbReference type="eggNOG" id="COG2078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095686_1_1_0"/>
    <dbReference type="InParanoid" id="B8E1G8"/>
    <dbReference type="OMA" id="WAIEVIE"/>
    <dbReference type="OrthoDB" id="1812209at2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00645">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
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        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023472">
        <property type="entry name" value="Uncharacterised_MJ0810"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="174" mass="19494" checksum="14A258A74B9740F1" modified="2009-03-03" version="1">MDLREYIVGLARKAIETYLKEGRVITPPPDIPDYLKRKAGTFVSLHRKSTGELRGCIGTIIPTTSNIAEEIIRNAISAATEDPRFPPLDLDELDDIEISVDVLSPLEEIKDIKDLDPKKYGVVVEKGWRRGVLLPDLEGVDTIEEQLSIALAKAGISPSENFKVYRFSVDRFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1H2</accession>
    <name>B8E1H2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0166</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352111.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0166"/>
    <dbReference type="EnsemblBacteria" id="ACK41497">
        <property type="protein sequence ID" value="ACK41497"/>
        <property type="gene ID" value="Dtur_0166"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0166"/>
    <dbReference type="HOGENOM" id="CLU_1114425_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1H2"/>
    <dbReference type="OMA" id="YKSWDER"/>
    <dbReference type="OrthoDB" id="2027600at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025368">
        <property type="entry name" value="DUF4272"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14094">
        <property type="entry name" value="DUF4272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="253" mass="30283" checksum="AB4AB17F88F5417A" modified="2009-03-03" version="1">MVKMEEEDILLNPPDEKTVINRAISVAVFFLRAQAEAIYSSSKDEEILKIEKNFFDEVEDWMEDENIINILSTREKLLLGKEIGKWEEMEIFLSLSYLEDLGILLWALSFIDKIPPYEEGFKLNDVIDLIPVLKSREEFENRAKLRNYKELMKEREIAELWYFRWKLGRMMKENYKLEEGKSYDEAIKILTEKALSLGAIKEILENDFPIKGRPFSHLEKEDYIYISNIIIERYLTLNWLCGYYKSWDERKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1J8</accession>
    <name>B8E1J8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tagaturonate/fructuronate epimerase</fullName>
            <shortName evidence="1">D-TagA/D-FruA epimerase</shortName>
            <ecNumber evidence="1">5.1.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uxaE</name>
        <name evidence="2" type="ordered locus">Dtur_0194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the epimerization of D-tagaturonate (D-TagA) to D-fructuronate (D-FruA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>keto-D-tagaturonate = keto-D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:51656"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
            <dbReference type="ChEBI" id="CHEBI:59881"/>
            <dbReference type="EC" id="5.1.2.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaE family.</text>
    </comment>
    <dbReference type="EC" id="5.1.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582608.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352137.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="SMR" id="B8E1J8"/>
    <dbReference type="STRING" id="515635.Dtur_0194"/>
    <dbReference type="EnsemblBacteria" id="ACK41523">
        <property type="protein sequence ID" value="ACK41523"/>
        <property type="gene ID" value="Dtur_0194"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0194"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.200"/>
    <dbReference type="eggNOG" id="ENOG502Z82R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038563_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1J8"/>
    <dbReference type="OMA" id="TIAPKFT"/>
    <dbReference type="OrthoDB" id="647950at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016856">
        <property type="term" value="F:racemase and epimerase activity, acting on hydroxy acids and derivatives"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02243">
        <property type="entry name" value="UxaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032586">
        <property type="entry name" value="UxaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16257">
        <property type="entry name" value="UxaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="485" mass="56660" checksum="F23A4ED09DA05432" modified="2009-03-03" version="1">MLKLLNESLKPLSIFIYSESLRKINDDLYIFVAKIKDLKKIGIVKQNQILYFSSPYFSEDKKIEGTNFLVNLYPLNFENYQKLKEIIPISPKVCDKKISFGTGDRLGLITSAQLSALKEYDLFPILAQQSPRELIKTKRDFKDVLLKSAMGVLETGYTGKYGADADHIKDEKYLMEAIDAGYTMYTLDISDFIEKIKDLSEKALKEKYEKVSSFSKKIIDKYAGKRVKISDEEYFELSYNELCKSAIVYEKALSFVEMVYEILKSKLSEFDIEVSIDEGERDTTPEDHFFVAQFLHDKGIDFKSLAPKFPGEFQKGIDYIGDIKEFERALKKHYALTKALEGYRLSLHSGSDKFSIYKIFYKITEGNFHIKTSGTSWLEAVKVIAKFFPDLFVELYQIALENLEESKKAYKVNITKEEFPKEIKEDYMEFLHKDNVRQLFHISYGVLLDEKRKEIYDLLNQKEKEHYQYVSENIKKHLKNLFEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1J9</accession>
    <name>B8E1J9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582609.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352138.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0195"/>
    <dbReference type="EnsemblBacteria" id="ACK41524">
        <property type="protein sequence ID" value="ACK41524"/>
        <property type="gene ID" value="Dtur_0195"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0195"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.201"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_0"/>
    <dbReference type="InParanoid" id="B8E1J9"/>
    <dbReference type="OMA" id="KVISCHS"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="4">
        <location>
            <begin position="17"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="5">
        <location>
            <begin position="114"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="336" mass="37691" checksum="140C51A86CF71584" modified="2009-03-03" version="1">MYRIAVVNSSSFGKYFPEHMEKLKKIGEVERFSLPGDLHGRELAEKLMGFNIIVASVTPFYDEEFFEYKDETLLITRHGIGYNNIDINSATEKGTIVTKVPGVVEREAVAETAVALLMTVIRKIREASLKAREGKWEERAQFIGWEVKDKVVGIIGYGNIGSRVGEILKNGFNAKVIAYDPNIPAEVLREKGAEPVSFEELLKISDIISLNASLNEKSRHMISEREFSMMKDNVIIINTARGELMDEEALIRAIKSGKVAGVGLDVMKDEPPDPQNPLLHMENVVVTPHIAAYTYECLKGMGDKVVSDIEKVVNKEIPDEIINKEVLERLPWTKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1P1</accession>
    <name>B8E1P1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator receiver protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0239</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582651.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352180.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0239"/>
    <dbReference type="EnsemblBacteria" id="ACK41566">
        <property type="protein sequence ID" value="ACK41566"/>
        <property type="gene ID" value="Dtur_0239"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0239"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_0"/>
    <dbReference type="InParanoid" id="B8E1P1"/>
    <dbReference type="OMA" id="THDEQDF"/>
    <dbReference type="OrthoDB" id="930905at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="128" mass="14679" checksum="FDD5AC06F21EA95D" modified="2009-03-03" version="1">MVKVFIIDDSKDFINSAIKLLTEEGIEVIGYAYSGKEGIESLQNLNPDIVFVDIVMPDMDGFSVIKELKKLNNPFKTVILTLYDNDEYRKVSEEIADGFVSKSDFFSKIKEILEGILREEKKKTIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1T6</accession>
    <name>B8E1T6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Autoinducer 2 import ATP-binding protein LsrA</fullName>
            <ecNumber evidence="8">7.6.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. AI-2 autoinducer porter (TC 3.A.1.2.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.13" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582804.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352333.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0415"/>
    <dbReference type="EnsemblBacteria" id="ACK41719">
        <property type="protein sequence ID" value="ACK41719"/>
        <property type="gene ID" value="Dtur_0415"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0415"/>
    <dbReference type="eggNOG" id="COG1129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_92_3_0"/>
    <dbReference type="InParanoid" id="B8E1T6"/>
    <dbReference type="OMA" id="NVHLGHE"/>
    <dbReference type="OrthoDB" id="551294at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905887">
        <property type="term" value="P:autoinducer AI-2 transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030281">
        <property type="entry name" value="LsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43790:SF2">
        <property type="entry name" value="PTHR43790:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="243"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="503" mass="56269" checksum="3D88F1200667886B" modified="2009-03-03" version="1">MEDYILEVRNIYKSFTGAKPVLEGVNFNLKKGEIHALLGENGAGKSTLIKIISGVLQPDHGDILLKGKKVYFGNPMDAQKHGIAAVFQELALFPELSVAENIFIGHYKYRTLFRSIDWKDLYKEANSFLNSLGIEIDPKALVKDLSIAERQIVEIARVLSINPEILIMDEPTSSLTLEETQRLFNIVRSLKEKGTSIIFISHRLEEVFAIADRVTVLRDGQYIGTKNVAETSVDELIQMMVGRKLEDMYPKVETKKGELLLKVDGLTRNGEFYDVSFELFEGEVLGIAGLVGSGRTEVAQTIFGIRSKDKGKIYIRGEEVNIKNPKDAISLGIVYVPEDRHQHGLLLPMDIVCNTTLPILESLANRGIIDRKEEEILTKKYFELLDIRASGIRQKVMSLSGGNQQKVVLAKWLATKPKILILDEPTRGIDVGAKVAIYQLINKLAQEGYGIILISSEMPEIIGMSDRIIIMHEGRIVGTISRREATQEKILSMALGRKVYTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1X4</accession>
    <name>B8E1X4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0456</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582842.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352371.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0456"/>
    <dbReference type="EnsemblBacteria" id="ACK41757">
        <property type="protein sequence ID" value="ACK41757"/>
        <property type="gene ID" value="Dtur_0456"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0456"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.481"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1969489_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1X4"/>
    <dbReference type="OMA" id="IRNMNTE"/>
    <dbReference type="OrthoDB" id="1654130at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="117" mass="13031" checksum="82BBF951E0C6CE14" modified="2009-03-03" version="1">MKGLLLCVCQGTCPSFQNMNIFEIANTLRREGLIDFVAIHPQLCADDGDNFLSTFVKDGDSIEKLVIAGCDPKMQAKMFRDAFEKAGFDRTRHVGVDIRNMNTEEAISTIKKALSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Y1</accession>
    <name>B8E1Y1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PNP_UDP_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582849.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352378.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0464"/>
    <dbReference type="EnsemblBacteria" id="ACK41764">
        <property type="protein sequence ID" value="ACK41764"/>
        <property type="gene ID" value="Dtur_0464"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0464"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082375_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1Y1"/>
    <dbReference type="OMA" id="CLHYKVR"/>
    <dbReference type="OrthoDB" id="1728178at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042601">
        <property type="term" value="C:endospore-forming forespore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003913">
        <property type="term" value="F:DNA photolyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="277" mass="32354" checksum="6D5FF7704695B701" modified="2009-03-03" version="1">MIYITIAFYVEGKPIIDYFNLKKLNDSSKFQIFNKDEIFLIISGEGNINSAIATTYLLTKYGWKNEDIALNIGICGAKDGGFSKGDLILCNKIINHNSKRAFYPDILISHDMKEASLESFDFPVRKCHQEEIEGDIVDMEGAGFFEAASSFLYSHNIHCIKIVYDLLDFDKIDPKMVQEIIIKNIFKIENFINSLLTLNEKYLQRREDKKIKEILEKLKSNLHLTRSMEIELKKLLKIYLIRYKQIPEEIEEFVNIKVNSKKEGKEYFEKLKNFLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Z2</accession>
    <name>B8E1Z2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Dtur_0475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582860.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352389.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0475"/>
    <dbReference type="EnsemblBacteria" id="ACK41775">
        <property type="protein sequence ID" value="ACK41775"/>
        <property type="gene ID" value="Dtur_0475"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0475"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.501"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_3_0"/>
    <dbReference type="InParanoid" id="B8E1Z2"/>
    <dbReference type="OMA" id="GNIAIEM"/>
    <dbReference type="OrthoDB" id="1325025at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="66"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ACK41775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="302" mass="33261" checksum="F1F01EC6ADEC08E9" modified="2009-03-03" version="1">MRRNFGDIIFKIIAILSSLILIALVVFLFIELLIYSFPSIEKFGIKFLIEKVWDPVAEKYGALPAIYGTLVTSFLALLIAFPLSIGIAIFISELSPPLLQRPLSFIIELLGAIPSLIYGMWGLFSLAPLIQLKVGPFLQKILGFLPFFQGYPIGVGYLTASLVLSIMIIPTISSLSREILMAVPKDQREAGYALGMTKWEVIWRVVLGNARSGVFAAGILGLGRALGEAVAVTMVIGNFYDIAISLFSPGVTITSVIINEFAEATGKLKISVLMELALILFLITFLVMGFARYYILKRTERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Z6</accession>
    <name>B8E1Z6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactarate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.42</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UxaA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.42" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582864.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352393.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0481"/>
    <dbReference type="EnsemblBacteria" id="ACK41779">
        <property type="protein sequence ID" value="ACK41779"/>
        <property type="gene ID" value="Dtur_0481"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0481"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.506"/>
    <dbReference type="eggNOG" id="COG2721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029189_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1Z6"/>
    <dbReference type="OMA" id="DVGWELF"/>
    <dbReference type="OrthoDB" id="889365at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008867">
        <property type="term" value="F:galactarate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019698">
        <property type="term" value="P:D-galacturonate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007392">
        <property type="entry name" value="Gal/Altron_deHydtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04295">
        <property type="entry name" value="GD_AH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GD_AH_C" evidence="3">
        <location>
            <begin position="5"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="385" mass="41924" checksum="825378503D901A00" modified="2009-03-03" version="1">MERITFKGYRRPDGRVGVRNYVAIISVDDISNTAVEGICKLISGTLPVTHPYGRLQFGRDLDLFFRTMIGTGANPNIASAIVIGIEENWANKIAEGISKTGKPVEAFYIEGYGDLRTIERASRVAMKLVQDASEIEREEVDISELVMSIKCGESDTTSGLAANPTVGKVVEKLLSYGGTVLFGETSELTGGEHIIAQRIKDEKQRQRFWDMFNEYQEFIKNEGVDLLGSQPTEGNIKGGLSSIEEKALGNIQKIGKAQIDGVLEMAETPPGRGLYFMNTSSAAAEAITLFAAGGAVVHLFPTGQGNVVGNLVIPVIKISGNPKTVSTMSEHIDVDVSKVLTLEESLDEAGEKLWNYLLRVISGKLTCAEVLNHKEFVLTKFFRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E204</accession>
    <name>B8E204_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582872.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352401.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0489"/>
    <dbReference type="EnsemblBacteria" id="ACK41787">
        <property type="protein sequence ID" value="ACK41787"/>
        <property type="gene ID" value="Dtur_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0489"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="InParanoid" id="B8E204"/>
    <dbReference type="OMA" id="MAFPVYW"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="69"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="274" mass="30771" checksum="1396328939350F39" modified="2009-03-03" version="1">MRKKLIKSLIFILASVILIIELFPVILLFLTSIKTNMAIWTSPTPFHPFKPTIEQYVGVFRETTFFKNIFNSTYIALWTTFLSVLGGSLASYALARFPLKKRREISMGIIFTRMIPQIALAVPIYYLFRRIGLLDTYTGMILAHTTFNLPYVVWLLLPFFQQIPKEFEEAALIDGCSHVKVFTKIFLPLASSGIIVAIIFCFLGSWNDFIYTLVLSNVKTTTAPMLVTTFVGMYAPEVGKMSAAGILIILPVFILALVLQRYIIMGLSGGGIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E209</accession>
    <name>B8E209_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582877.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352406.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0499"/>
    <dbReference type="EnsemblBacteria" id="ACK41792">
        <property type="protein sequence ID" value="ACK41792"/>
        <property type="gene ID" value="Dtur_0499"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0499"/>
    <dbReference type="HOGENOM" id="CLU_823180_0_0_0"/>
    <dbReference type="OMA" id="KELISWF"/>
    <dbReference type="OrthoDB" id="2107725at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="331" mass="39282" checksum="193D97CC327C42A2" modified="2009-03-03" version="1">MKFPLGQEIYKRTPVYLINLKELISWFRLERFNGVLVEEVSNVNTQVLVYDGIIPKAFTERNGEILAEDSNAIEIFVNDYLARNGFLSLFSYDKELIPPLLILYFSTPNIFREESYLFIPERLIEESKKENSISHILIENSEDKVHFLFYDGKFKGYYSEKDGIIKEDISFLSELFNKSDSFISFYQISCGEFHKLNIPSLKFSFIEEEITKWVEKLLEYVNFIMRYYESHGMYIENTNKILDGLNILCSSLVCLDNKFIIKKEIMGSYEEVEGEIVEVIRRINRELSDLWGEKFVHQKYIQGYKKFIEEYKNDKKIIELLDRINPENIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E220</accession>
    <name>B8E220_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583380.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352911.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1017"/>
    <dbReference type="EnsemblBacteria" id="ACK42297">
        <property type="protein sequence ID" value="ACK42297"/>
        <property type="gene ID" value="Dtur_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1017"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1054"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_0"/>
    <dbReference type="InParanoid" id="B8E220"/>
    <dbReference type="OMA" id="YHFYPGS"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="67"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="335" mass="38250" checksum="A7D963238FDCC8DC" modified="2009-03-03" version="1">MREALYYQKLENQIVQCLLCPHHCIIPLGKRGICGVRENIEGTLYSLVYGKASSIALDPIEKKPLYHFYPGSAILSIGTVGCNFKCPFCQNWTISQVGPEDIFLEDVDKELLLKLAKKNGSIGISYTYNEPFIWYEFVLEVAKHFKEHNLKNVFVTNGFIEVEPFLEIAPYIDAMNIDLKSIREEFYNKLCKGSLKGVKRIIEFAYEKGIHIELTNLIIPGYNDNKEEIVALIDYVASISPNIPLHFTRYFPAYKFTVPPTPIEILKFAYSEARKRLHYVYLGNIWDTEGSTTFCPNCGNELIVREGYFIRKNLLKNSNKCPYCGTSIPVHTGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>B8E245</accession>
    <name>B8E245_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583405.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352936.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1042"/>
    <dbReference type="EnsemblBacteria" id="ACK42322">
        <property type="protein sequence ID" value="ACK42322"/>
        <property type="gene ID" value="Dtur_1042"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1042"/>
    <dbReference type="HOGENOM" id="CLU_2681821_0_0_0"/>
    <dbReference type="OMA" id="FIGFWKT"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018730">
        <property type="entry name" value="DUF2273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10031">
        <property type="entry name" value="DUF2273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="74" mass="8898" checksum="B90050F130FE3D3A" modified="2009-03-03" version="1">MNFKIPNLREYRYRIIFSFVFLIIGILILLIGFWKTLFLVFCFLVGYLVGLAIDKNFILEVIEKIKEIFYIGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E264</accession>
    <name>B8E264_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1061</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583424.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352955.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1061"/>
    <dbReference type="EnsemblBacteria" id="ACK42341">
        <property type="protein sequence ID" value="ACK42341"/>
        <property type="gene ID" value="Dtur_1061"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1061"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8E264"/>
    <dbReference type="OMA" id="LMMLERP"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="9"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="37902" checksum="6737C393F0CEB4F2" modified="2009-03-03" version="1">MSNNNNILLRVENLKVWFEIRKNILAKPMYVKAVDGVNFELKKGESISLVGESGSGKTTLGRTILRLYEPTDGKIVFEDKDITKADYKELNWYRKETGFVQQDPFGALVPHFTIYRILEEPLLINKIGTPGERREMIFKALEEVKLTPVTDFIGKYPHMISGGQMQRVVIARALIMKPKLVIADEPVSMLDASVRIEILELLRDLQESHHMSMIYITHDLATVRAFSNWIFIMYAGNLVERARTEELLNNPLHPYTKALLSAIPDPDPQNRFKLREVPPGEPPNLINPPSGCRFHPRCQYVMDICKEKEPEEIEVSKEHWVKCWLYKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E286</accession>
    <name>B8E286_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352977.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1084"/>
    <dbReference type="EnsemblBacteria" id="ACK42363">
        <property type="protein sequence ID" value="ACK42363"/>
        <property type="gene ID" value="Dtur_1084"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1084"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1120"/>
    <dbReference type="eggNOG" id="COG5401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080926_4_1_0"/>
    <dbReference type="InParanoid" id="B8E286"/>
    <dbReference type="OMA" id="DGICYAN"/>
    <dbReference type="OrthoDB" id="1101485at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="64"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="169" mass="19213" checksum="0636016FF42EFB02" modified="2009-03-03" version="1">MKKIVVGISFSLLLIFVIFLLFFFPFKTKVVLYTYDSNNQSLRRTDSEIEVSLAERLVFKNNLYKKVILKLIEESDSNKDHFPIPKGTRLLSVSLKDEVAYVNFSEEFKRNHPGGSLGEILTIYSIVDTLTEFPEIKKVQILIGGAVVETLAGHIDLTSPLERDLSMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2A4</accession>
    <name>B8E2A4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxyl-terminal protease</fullName>
            <ecNumber evidence="5">3.4.21.102</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.102" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583464.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352995.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1102"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="ACK42381">
        <property type="protein sequence ID" value="ACK42381"/>
        <property type="gene ID" value="Dtur_1102"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1102"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1138"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_1_2_0"/>
    <dbReference type="InParanoid" id="B8E2A4"/>
    <dbReference type="OMA" id="TFNQVDW"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="101"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="418" mass="47132" checksum="696C9F3C5E2A821E" modified="2009-03-03" version="1">MRIKIRVWLLLSVVIIGIGVFLLPKFTIAKDSLEDIISSVKVYIEALYYVRNAYIEKNLDNKKLEYESIRGMVKALDDPYTEFFDPKSFKTFTEDMQGVFGGVGIRLESKDGKILVVSPIENTPAHRAGIKPGDQIVEVDGQSVINKPLDVVVSLIRGEIGKEVKIKIYRESEKKYYEYTLKRELIEVPVVEYKTLKNNIGYIKFYEFTQNSPQKIIDALKKLEKSSGLILDLRNNPGGDLRSAVMIASMFISDNDQVKTVIKNGETKTFTTKGVVVYRMDRNQNLYGEKVVKGLYRWNKPLVVLVNRYSASASEILSGALKDYGKGILLGEKTFGKGVVQTIFTLSDGSALKLTTEKYLLPSGKDINKEGIQPDVIVEMAPENVGKDNDIQLEKAIEVLLKQLSKLKEKEKLVLNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2A6</accession>
    <name>B8E2A6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ComEC/Rec2-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583466.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352997.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1104"/>
    <dbReference type="EnsemblBacteria" id="ACK42383">
        <property type="protein sequence ID" value="ACK42383"/>
        <property type="gene ID" value="Dtur_1104"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1104"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_528607_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2A6"/>
    <dbReference type="OMA" id="HFYLIYI"/>
    <dbReference type="OrthoDB" id="1796527at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Competence" evidence="7">
        <location>
            <begin position="195"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="448" mass="52489" checksum="5E688351D2842920" modified="2009-03-03" version="1">MKFPYSFYFLIFYILGIIFAKINLSFVYFFLFLLLLVFVINRKSKIYFYITLIFLFLLGFYLYRISFPQFEVYSNAKLKSLTGIVEDSFEGKDFNSYVIKIEGFKEKGKLNIKNRKFEIGDKILLEGVGLYPLNQGNLYSLWDEDILYLIKAEKIYLIKRGYKNSLERIRNNLRNRISNVYSVFEDYKEQFLLAIVMGERRGLSEDVKNLFVNTGTSHLLAISGLHLSFLINIFSALIPLRRILVRIVILPLLVFYGWIIGDNPPVWRVIGQYVFILLAFLLRREEDNLNAIFWVAFVNLVISPLKLFNVSFQLSYLAMLGLLYKPNFSKFLPAYLQEIWESSFWLMIFLAPLNIYYFGSLKPISIIANFFAIPIFSLVLFFSFLYLIGFSLPMGFIFEKILSKLIDILFESLQLIGEHYKISLLISVSLILLPVILRKREENELLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2F9</accession>
    <name>B8E2F9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mg chelatase, subunit ChlI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mg-chelatase subunits D/I family. ComM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583879.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353417.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1529"/>
    <dbReference type="EnsemblBacteria" id="ACK42803">
        <property type="protein sequence ID" value="ACK42803"/>
        <property type="gene ID" value="Dtur_1529"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1529"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1578"/>
    <dbReference type="eggNOG" id="COG0606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026145_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2F9"/>
    <dbReference type="OMA" id="STNPCPC"/>
    <dbReference type="OrthoDB" id="581802at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045006">
        <property type="entry name" value="CHLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004482">
        <property type="entry name" value="Mg_chelat-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025158">
        <property type="entry name" value="Mg_chelat-rel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000523">
        <property type="entry name" value="Mg_chelatse_chII-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039">
        <property type="entry name" value="PTHR32039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32039:SF7">
        <property type="entry name" value="PTHR32039:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01078">
        <property type="entry name" value="Mg_chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13335">
        <property type="entry name" value="Mg_chelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00368">
        <property type="entry name" value="TIGR00368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="209"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="506" mass="57261" checksum="C35E87D1F670215B" modified="2009-03-03" version="1">MLSKIRSATLLGLNCHEVEIEIDISSGVPSFNIVGLAEQEIQESKERVRSALKNSGYEFPLKRITINLAPADLKKNSPLFDLPIAIGILSNYMNFDFNPEESAFFGELSFEGKIRKGKGLLSLVYGLKNKGYKRFFVPKENEFECALVDEVEIYPISHISELVKFLTGEIKIKPLKYSFPDYIPTFSEDFSFIKGQAYAKRALEISAAGGHNVLLVGPPGTGKTLLARTFPSILPPLTYEEAFEVTQIYSAAGLLDKESLVLERPFRNPHHTISYAGLLGGGSNPQIGEITLAHRGVLFLDELPEFRRDVLEALRQPLEEGRIVISRSKYTVVYPAQFILLAGMNPCKCGHFGDKEKECTCSPFEVKKYWSKVSGPLLDRIDIRVYVGRIEKEKIFSDTEEESSEEIRKRVIEAREIQKERYKKEKFQLNSQLTPKTLKKYGVLSKDVQRFLLDAVDGKNLSMRAVDRIIKVARTIADLEKNEYIRIEHLAEALSYRGLEDFISNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2J1</accession>
    <name>B8E2J1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583910.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353449.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1561"/>
    <dbReference type="EnsemblBacteria" id="ACK42835">
        <property type="protein sequence ID" value="ACK42835"/>
        <property type="gene ID" value="Dtur_1561"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1561"/>
    <dbReference type="eggNOG" id="COG1503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061559_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2J1"/>
    <dbReference type="OMA" id="PRPREWE"/>
    <dbReference type="OrthoDB" id="739234at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041202">
        <property type="entry name" value="BaeRF_family10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PTHR10113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18854">
        <property type="entry name" value="baeRF_family10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="369" mass="42850" checksum="0CA640B7F773AD51" modified="2009-03-03" version="1">MLSKEILKELGNFSLQPYFITTLYLNVSPLSNPKGEYKIIWKDLKKNFLESLNLEGEIKKSVLSDLEYIENLIDQVSFGSANTIVLMSCSAKDWRYQIPLYPILKNKLVIDKDPYTRPLSYLITANKPYYLVVLSRGDARVFKYFIGEIREEGEIKEEIPKKHKQGGWEASDWQRWHETHVIWHFKEVAEFLDKKIQGEEKIVLGTTSPKNTSEFLDVLPKRLHEKIIGEIPIELDSPINEILEKTHNMIEAHEENEINDLIDQLIVTNAKGKEAVIGLEDVAHAVHQKRVRMILVYDQFEQPGFQCPSCSFMSPYLENCPYCNVKMEKRADIVDELIEEAIINNSELKYIKNKELAEKIKNIGAFLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2K0</accession>
    <name>B8E2K0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353458.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1570"/>
    <dbReference type="EnsemblBacteria" id="ACK42844">
        <property type="protein sequence ID" value="ACK42844"/>
        <property type="gene ID" value="Dtur_1570"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1570"/>
    <dbReference type="HOGENOM" id="CLU_2478374_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="87" mass="10257" checksum="A7456BA924F7AD85" modified="2009-03-03" version="1">MIEKVINYLKDSNYIVDVKKLKKDLSLSDEEWDLILLQLRDLGYIKEINKLDPSSCKNCPYTKVCSQQCLQSEILYFELPHKDQDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2L0</accession>
    <name>B8E2L0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative PAS/PAC sensor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583929.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353468.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1580"/>
    <dbReference type="EnsemblBacteria" id="ACK42854">
        <property type="protein sequence ID" value="ACK42854"/>
        <property type="gene ID" value="Dtur_1580"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1580"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1628"/>
    <dbReference type="eggNOG" id="COG2461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026706_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2L0"/>
    <dbReference type="OMA" id="LCHPPKS"/>
    <dbReference type="OrthoDB" id="565213at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007380">
        <property type="entry name" value="DUF438"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04282">
        <property type="entry name" value="DUF438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="406" mass="47746" checksum="38D8C21F426670AE" modified="2009-03-03" version="1">MSEVFGLRKERKEMLKELIRKIHKGEDPEKLKTRFKDIFGSVTTTEIAEIEQELIQEGMPREEVMRLCEIHLKVFEEALEKDKVDSQAGHPVTILMSEHKKLIEFSERLKKAVEELKLAGDFEEGEDKLREIIDIVDHFKEAEKHYLREENVLFPYLEKHGITEPPAIMWMDHDKIRSIKKGIFNMVESFQGFSFENFVNTLLYKAVELGDTMSSHFYKENNILFPMGLHVITEEEWRDIRIQFDEIGYCCFTPPEVLTPVERKKEVSVQVEDKMRLPSGSFTLAELKAVLNTLPVDITFVDKNDEVKYFNETKDRIFVRTRAVIGRKVQQCHPQKSVHIVEKILDEFKKGTKDHADFWINVNGRLIYIRYFAVRDEDGNYLGTLEVTQDITEIKKIEGERRLLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2M3</accession>
    <name>B8E2M3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583942.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353481.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1594"/>
    <dbReference type="EnsemblBacteria" id="ACK42867">
        <property type="protein sequence ID" value="ACK42867"/>
        <property type="gene ID" value="Dtur_1594"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1594"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_309660_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2M3"/>
    <dbReference type="OMA" id="YDFYNRF"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13416">
        <property type="entry name" value="SBP_bac_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="961" mass="110662" checksum="72804F1AE2496869" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2P2</accession>
    <name>B8E2P2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ruvA</name>
        <name evidence="10" type="ordered locus">Dtur_1613</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583961.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353500.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1613"/>
    <dbReference type="EnsemblBacteria" id="ACK42886">
        <property type="protein sequence ID" value="ACK42886"/>
        <property type="gene ID" value="Dtur_1613"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1613"/>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087936_3_1_0"/>
    <dbReference type="InParanoid" id="B8E2P2"/>
    <dbReference type="OMA" id="YKHENAY"/>
    <dbReference type="OrthoDB" id="1370858at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="192" mass="22245" checksum="FF86ACAF9838A76A" modified="2009-03-03" version="1">MAFLNHIYGKLLKIHGDSLIIDTGNFGFKIYVSKNLTSKLSEELNNKILLYIAEVIEKDGIKFFGFLSEEERDLFERLKNITGVGIKIALRIVSAMSPKEFYEVIEKEDLNALLMVPGVGKKITQKIFLEIKGVIPKREHKEEDIIKDTLLNLGYKKEEIEVVMKEIRKEFKDLDNLEEIIRFALRKLSQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2R1</accession>
    <name>B8E2R1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Roadblock/LC7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583494.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353025.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1132"/>
    <dbReference type="EnsemblBacteria" id="ACK42411">
        <property type="protein sequence ID" value="ACK42411"/>
        <property type="gene ID" value="Dtur_1132"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1132"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118613_4_2_0"/>
    <dbReference type="InParanoid" id="B8E2R1"/>
    <dbReference type="OMA" id="ASEMIGM"/>
    <dbReference type="OrthoDB" id="2127523at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="PTHR13323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="118" mass="12343" checksum="E1F308DE53D93DCC" modified="2009-03-03" version="1">MASIRETLEEISKLDGVQVSVLVSDDGLLIESVAKDSSNTESLAAVASGSLRASEMIGMELAKGSTREMVIIFEDGAVFIVPLEGKPAILVVVSSKGANLGKIRVGIKKGAFQLARLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2R7</accession>
    <name>B8E2R7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583499.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353031.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1138"/>
    <dbReference type="EnsemblBacteria" id="ACK42417">
        <property type="protein sequence ID" value="ACK42417"/>
        <property type="gene ID" value="Dtur_1138"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1138"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113198_4_2_0"/>
    <dbReference type="InParanoid" id="B8E2R7"/>
    <dbReference type="OMA" id="CYGLVGM"/>
    <dbReference type="OrthoDB" id="1961470at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="142" mass="16089" checksum="C7C5393A1331958B" modified="2009-03-03" version="1">MRWIQDFISKKEKNKQKYFTGLGWVEISPSAIATLASIATLQSYGVVGMAASNIADGISELLKLEEVSRGVRVEIDEDGIKIDLYIIVAYGVRIPEVAHNVMERIKWSLERTTGLNVKEINVNVWGIRVKEEKEPIVWEEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2U9</accession>
    <name>B8E2U9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">XcmT3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583531.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353063.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1170"/>
    <dbReference type="EnsemblBacteria" id="ACK42449">
        <property type="protein sequence ID" value="ACK42449"/>
        <property type="gene ID" value="Dtur_1170"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1170"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_7_3_0"/>
    <dbReference type="OMA" id="PRYFDAV"/>
    <dbReference type="OrthoDB" id="2139624at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="129" mass="14432" checksum="ACA6874ABB5C8325" modified="2009-03-03" version="1">MKNSKGFSLLELLVVIAILGILVAIALPRYFDAVADAKKAAQKSNVAIIRTSLEYYRNKNNKYPQLTEFNSFISSQTYFAEPLVCPYNNKTYSVVDLTATSTYWGTSGNEHYLGYTSTDNSYTLVYTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2X9</accession>
    <name>B8E2X9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome-recycling factor</fullName>
            <shortName evidence="3">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">frr</name>
        <name evidence="5" type="ordered locus">Dtur_1200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583561.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353093.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1200"/>
    <dbReference type="EnsemblBacteria" id="ACK42479">
        <property type="protein sequence ID" value="ACK42479"/>
        <property type="gene ID" value="Dtur_1200"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1200"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1238"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_0"/>
    <dbReference type="InParanoid" id="B8E2X9"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRF" evidence="4">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="185" mass="21705" checksum="DCE5F404A639C74D" modified="2009-03-03" version="1">MGKEHFKEIEEKMKKAVEVVKKEFQNIRTGKPSVGIFDEIKVSYYGNMMPLNQVATLKVAEGRTVLIQPWDKSIIGEIEKAILKSELGLTPQNDGQVIRVVFPPLTEERRKELVKIVHKEAETGRVAIRNIRRDYLEIFKKEKQEGKISEDEFYRLQEELQKITDKFIEEIEKLIEMKEKEIMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Y6</accession>
    <name>B8E2Y6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YlxR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583568.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353100.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1207"/>
    <dbReference type="EnsemblBacteria" id="ACK42486">
        <property type="protein sequence ID" value="ACK42486"/>
        <property type="gene ID" value="Dtur_1207"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1207"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1245"/>
    <dbReference type="eggNOG" id="COG2740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147970_2_1_0"/>
    <dbReference type="InParanoid" id="B8E2Y6"/>
    <dbReference type="OMA" id="CVGCQEM"/>
    <dbReference type="OrthoDB" id="2067975at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00279">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="2">
        <location>
            <begin position="10"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="98" mass="11201" checksum="35FFFD82F5A9C7D7" modified="2009-03-03" version="1">MSKGKHIPLRTCIGCGEKKPKRELLRIVRGENNSIFYDPTGKASGRGAYICPKIECLELAIKKRAFSHALKCEISKEDLERIREELEREITKRGEMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Z3</accession>
    <name>B8E2Z3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotin/acetyl-CoA-carboxylase ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583575.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353107.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1214"/>
    <dbReference type="EnsemblBacteria" id="ACK42493">
        <property type="protein sequence ID" value="ACK42493"/>
        <property type="gene ID" value="Dtur_1214"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1214"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1252"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_5_2_0"/>
    <dbReference type="InParanoid" id="B8E2Z3"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="241" mass="27753" checksum="71FC01806F0A4B49" modified="2009-03-03" version="1">MRLIIYLDKLTSTMDIAHILAEKGYPHGTVIVAEEQTQGRGRFERKWYSPKGGLWFSIILRSKDLLIQSSFLGIIIGVSVLEVLEKFLKDIELNFKWPNDIEYNGKKVAGILIESIYEKELKYIIVGVGINLLVDPNDIKDLKAFSLRDYITTYDKNIVLIEVLEKLETNLNGFPHNWKEIFNFYKNKFPYIGKGVFIRNKNQKAKVIDMTEDGGIVLLTDNKVQKYEWGGVSLEFEGTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Z4</accession>
    <name>B8E2Z4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-superfamily hydrolase, subfamily IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583576.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353108.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1215"/>
    <dbReference type="EnsemblBacteria" id="ACK42494">
        <property type="protein sequence ID" value="ACK42494"/>
        <property type="gene ID" value="Dtur_1215"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1215"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1253"/>
    <dbReference type="eggNOG" id="COG0647">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043473_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2Z4"/>
    <dbReference type="OMA" id="MDGVLIH"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="265" mass="29683" checksum="D0940BA6CC758CE8" modified="2009-03-03" version="1">MSLKGLLIDLDGSIYKGNTSLHYSREFIEFLRKVNIKFLFLTNNSTQLPMDYVNKLRNMDIETKEEEILTSGIATAIYLSSLKNVGNAYVIGEEALKKAIISVNWKVLEDADYVDAVVVGLDRSFNFEKLRKANYLIRNGAKFIATNPDKTFPMENRIDPGAGSLVAAVSAASEKKPIVIGKPSPYIGKIALSKLGLKSHEVGIVGDRLDTDILFGKRLKIKTFLVLTGISKREDMEKSKIKPDFVFENLEEMTMFLKGYLENKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Z7</accession>
    <name>B8E2Z7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylate/guanylate cyclase with Chase sensor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353111.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1218"/>
    <dbReference type="EnsemblBacteria" id="ACK42497">
        <property type="protein sequence ID" value="ACK42497"/>
        <property type="gene ID" value="Dtur_1218"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1218"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1256"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_85_1_0"/>
    <dbReference type="InParanoid" id="B8E2Z7"/>
    <dbReference type="OMA" id="IMCFWGA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="425"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="611" mass="70814" checksum="97DA120EDEAA96CB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>B8E330</accession>
    <name>B8E330_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="7">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murE</name>
        <name evidence="12" type="ordered locus">Dtur_1252</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583612.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353144.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1252"/>
    <dbReference type="EnsemblBacteria" id="ACK42530">
        <property type="protein sequence ID" value="ACK42530"/>
        <property type="gene ID" value="Dtur_1252"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1252"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1292"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_0"/>
    <dbReference type="InParanoid" id="B8E330"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
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        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 7 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 7 8" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7 8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="11">
        <location>
            <begin position="112"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="10">
        <location>
            <begin position="330"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-MurNAc-L-Ala-D-Glu binding" evidence="7">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Meso-diaminopimelate binding" evidence="7">
        <location>
            <begin position="405"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif" evidence="7">
        <location>
            <begin position="405"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="381"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="492" mass="55766" checksum="35B6FB2F54AA917F" modified="2009-03-03" version="1">MRKLKEIVEYVREYVIETRGYLDGNITGIATDSRKVKEGNIFFALPGTRDDGRRYIGDAISKGARAVFFEGEVDNFERDVALIRVKEIFDVLSKVSLYFYNFPSKHLNIVGVTGTNGKTTTTSLLYHYWKGKGLKSGLIGTIDYRIDEESYPSNFTTPQPQELQEILSKMVNKGVKFLAMEVSSHALSLKRIDGVSLKAVVFTNLTQDHLDFHKTMEDYFQAKLKIFDHLEDEGFAVINRDNEWTKRINLADKRVLWASLEEGDIYLKKYENTNSGMILEIATPLGDTVIDTKLRGKFNIYNILFAVGVLIGLGEPLEDISKILSTFKGVKGRLEFIREGQNFNVIVDYAHTPDGLYNVLQTIKEFTKGRVIVVFGCGGDRDPTKRGKMGEISAKLADVVIVTSDNPRTEDPMKIIREIEKGIKRVGRLDYFVIENREEAIKKAIEIAKEDDSVLIAGKGHEDYQIIGTIKIPFSDQEIARKYILERLNNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E348</accession>
    <name>B8E348_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MscS Mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583997.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353536.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1649"/>
    <dbReference type="EnsemblBacteria" id="ACK42922">
        <property type="protein sequence ID" value="ACK42922"/>
        <property type="gene ID" value="Dtur_1649"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1649"/>
    <dbReference type="eggNOG" id="COG0668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_1_0_0"/>
    <dbReference type="InParanoid" id="B8E348"/>
    <dbReference type="OMA" id="GMQDTLT"/>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="256" mass="29035" checksum="8F91001BD81C3E80" modified="2009-03-03" version="1">MYMNIIWSLFILFVSFFIHKIIMKAINNVASRAGREIKAPKTVSMLIGFLIFGFGVAIILSIWNVNLMPYLTGLGISGVVLGLAFQEPLTNFLSGILVLVTRKVFEGEALDVDGISGIVDMVEMNHTRIKTFDGKMVLIPNRKVWSGTVTKFWPGPYRRVSFDVSVDYSSDLEKVISLLKRALEEEELVVKDESVNNMVVFKEYGNSGITYTVYFWVNRDSYFDAINALSTRIKKVFDENNISIPYMVVDLRITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E356</accession>
    <name>B8E356_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiazole biosynthesis protein ThiH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584005.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353544.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1658"/>
    <dbReference type="EnsemblBacteria" id="ACK42930">
        <property type="protein sequence ID" value="ACK42930"/>
        <property type="gene ID" value="Dtur_1658"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1658"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1708"/>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046249_1_0_0"/>
    <dbReference type="InParanoid" id="B8E356"/>
    <dbReference type="OMA" id="LICAYRL"/>
    <dbReference type="OrthoDB" id="419725at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012726">
        <property type="entry name" value="ThiH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034428">
        <property type="entry name" value="ThiH/NoCL/HydG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583">
        <property type="entry name" value="PTHR43583"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43583:SF1">
        <property type="entry name" value="PTHR43583:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00301">
        <property type="entry name" value="2-iminoacetate_synthase_(ThiH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02351">
        <property type="entry name" value="thiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="69"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="369" mass="42749" checksum="89F70CFD18D23FE9" modified="2009-03-03" version="1">MLREILKEADEILRKSHVLENKGGNVRKIIDKDKISKEDLFILLTDNSDETLILMANKAKRLTERYFGKVITLFTPLYLSNYCLSPCEYCGFSAKLQIPRKKLKEEEIIREYEAIKQTSIDSILLLTGCDKINTPFEYILYAVKLAKKYFSEISIEAYPMEEEEYRVLVKEGLTGVVQYQETYNKETYKKLHPVGPKSDYEYRLHTQERALNAGVYEVTVGVLLGINDPYEDVFKSILHAEYLSQKYPKAEINISFPRFRDPKTGFKPKYQVNEKLLLRFIFCARIYLPHVGITISTRENSRFRDNIIGYGVTKMSAGSKTTVGGYAQTETTSVQFETDDRRTVNEVINAIKNRGYRPEFTNWIKGGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>B8E361</accession>
    <name>B8E361_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353549.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1663"/>
    <dbReference type="EnsemblBacteria" id="ACK42935">
        <property type="protein sequence ID" value="ACK42935"/>
        <property type="gene ID" value="Dtur_1663"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1663"/>
    <dbReference type="HOGENOM" id="CLU_2192829_0_0_0"/>
    <dbReference type="OrthoDB" id="2134047at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="108" mass="11685" checksum="A2E5ABB47FFCEAFB" modified="2009-03-03" version="1">MTGKTLTIHMYIDPSLKGNNNGIQIFAKDSDWSYGAGPWINVSDSNVGTWTEVTLNFDNPNWSWAGGGSDGQLDITKIKAIGIKILMGGNAPAGETLEGSYWLDSINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E366</accession>
    <name>B8E366_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter sugar-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584015.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353554.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1668"/>
    <dbReference type="EnsemblBacteria" id="ACK42940">
        <property type="protein sequence ID" value="ACK42940"/>
        <property type="gene ID" value="Dtur_1668"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1668"/>
    <dbReference type="eggNOG" id="COG1879">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037628_3_3_0"/>
    <dbReference type="InParanoid" id="B8E366"/>
    <dbReference type="OMA" id="YEMGRQA"/>
    <dbReference type="OrthoDB" id="1378040at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025997">
        <property type="entry name" value="SBP_2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13407">
        <property type="entry name" value="Peripla_BP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peripla_BP_4" evidence="1">
        <location>
            <begin position="29"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="331" mass="37054" checksum="4B99C2686062ACBF" modified="2009-03-03" version="1">MKKLLVILFIVTVFLLMATTAQTPKKLVFAWIPKALNNPVFELGRDGAFKRAEELSKKGPYKVEVLYVASVASDATEQARVVEDVVARKVDGIAISCNDPTALIDVINKAVEAGIPVMTFDADSPKSKRFTYLGVNNYEGGKWAAKLLVKAMGTSGDVALLTGVPGALNLEERMRGFKDEIKKYPKIKIVTTVACYDDINRGVQVVEETMQKYPKLRGWFFVGLWPLFAERGSMPLWEKAAKAKKVFTVAFDTLPVELQLLKEGYLCGLVGQKYWGWGYDAIDILYRKVVNNEKFPDWIDSGMDIVTQKNVDAMIRAWLLKDFKTPLPPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E380</accession>
    <name>B8E380_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1682</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584029.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353568.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1682"/>
    <dbReference type="EnsemblBacteria" id="ACK42954">
        <property type="protein sequence ID" value="ACK42954"/>
        <property type="gene ID" value="Dtur_1682"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1682"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_0"/>
    <dbReference type="InParanoid" id="B8E380"/>
    <dbReference type="OMA" id="GHDHVHP"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="247" mass="28318" checksum="D3DAD65C20AAEAA9" modified="2009-03-03" version="1">MNKILEIKNLYHSYNHELILENINLHLLEGEFLGIIGPNGAGKSTLLKIIVGIIKPLKGTVKVFNKDVQFLNEEKKWIGYVPQKPDLEKYLPLKVKEIVALGRRVANNWQKLTAYDFDLIDRVMEEMEIKDIENKIYGELSGGQQQRVLIARALAQEPKLLILDEPTVGVDISTQNKFYTLLRNFKKQNTSVILVSHDIGIITKEVDKLACLNRKLYLHGCPEEIAIHGTLKELYGENFLFLTHKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3A4</accession>
    <name>B8E3A4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1706</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584053.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353592.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1706"/>
    <dbReference type="EnsemblBacteria" id="ACK42978">
        <property type="protein sequence ID" value="ACK42978"/>
        <property type="gene ID" value="Dtur_1706"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1706"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_0_0"/>
    <dbReference type="InParanoid" id="B8E3A4"/>
    <dbReference type="OMA" id="FIGPHVY"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="170"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="378" mass="42986" checksum="46B10ABA6051005E" modified="2009-03-03" version="1">MAEVEKREEFIEEVPEKEEKIYVASQWKLMWWRFRRNKLAIAGLVVLVIFYIIAAFCEFFAPYDPYKYDVRYVLAPPQRIHFVDEHGFHLRPFVYAYKMDIDPNTLRRIYSEDKTRKYPIKFFVRGHEYKLLGLFKTDIHLFGVEGDGHIFLFGTDSLGRDVFSRVIYGTRISTTVGLVGIFLSFLFGIIIGGISGYYGGPFDIIIQRIIEILRSIPTLPLWMALSAAVPANWSPVKVYFAISIILSFIGWTGLAREVRSKFLSLREEDFVTAAKLAGASEGRIIFRHLLPSFLSHIIASLTLSIPGMIIGETSLSFLGLGIRPPAISWGVLIQDAQNFRTVALAPWLLLPVVFVILVVLSFNFVGDGLRDAADPYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3B8</accession>
    <name>B8E3B8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide/dipeptide ABC transporter, ATPase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584067.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353606.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1720"/>
    <dbReference type="EnsemblBacteria" id="ACK42992">
        <property type="protein sequence ID" value="ACK42992"/>
        <property type="gene ID" value="Dtur_1720"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1720"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_0"/>
    <dbReference type="InParanoid" id="B8E3B8"/>
    <dbReference type="OMA" id="VACWLVE"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="328" mass="36729" checksum="2838BACE5D08B2AF" modified="2009-03-03" version="1">MEILKAENLRAYYLLDIGGELKSVRAVDGVDITIKENEIYGIAGESGCGKSTLIKTLYGMVEPPLNVIEGRVYYKINGELKDIFSLNGELGKIRWKYISYIPQGSMSVLNPVARIIDSFWDFIGSHEDISDRVRWKKHIEDYLTLLGLPTKILDAYPHQLSGGMRQRVTIALATVLTPKIIVADEPSTALDVVAQRAVIQLLKDIQKNLKNTIILVTHDMGVHASISDRIAIMYAGKIVEEAPTEVIFESPKHPYTKYLIGALPKIGDKSYKISAPGAPPSLLNPPKGCRFHPRCSYATEECREFVPRLVDIDTNHRVACFLYSKERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYI9</accession>
    <name>B8DYI9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ordered locus">Dtur_0033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582457.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351985.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0033"/>
    <dbReference type="EnsemblBacteria" id="ACK41371">
        <property type="protein sequence ID" value="ACK41371"/>
        <property type="gene ID" value="Dtur_0033"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0033"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.34"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_0"/>
    <dbReference type="OMA" id="RSINMTI"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051085">
        <property type="term" value="P:chaperone cofactor-dependent protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="89" mass="9950" checksum="3B343DEB1B77EBA4" modified="2009-03-03" version="1">MKKVLPLEDRVLVKIVKEEEKTPSGIILPDVAKEKPQIAEVIEVGDDETIKVKKGDKIIFAKYSGTEIKIDGEDYLILSKADILAKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYJ3</accession>
    <name>B8DYJ3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582461.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002351989.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41375">
        <property type="protein sequence ID" value="ACK41375"/>
        <property type="gene ID" value="Dtur_0037"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0037"/>
    <dbReference type="HOGENOM" id="CLU_975678_0_0_0"/>
    <dbReference type="OMA" id="SYIYLGT"/>
    <dbReference type="OrthoDB" id="2109222at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="286" mass="32246" checksum="7DEE4C957C158A49" modified="2009-03-03" version="1">MKKILIVFALLITLLLLNSTFATEVDESIYFDAKSSSLGFTFVTLDSEGETYFFNPATLSLKKFSYFSLTFDNLTDNPNLKLSYFYPSTTIYSITADLILDKNTKEYSLKNIRGAIAFPLTSYIYLGTSAMYLEEENLIKGDIGLMIKIGDFLRTGIVGEGFTIEKISDQVYKITLALRYNIGLSFSLFNNSTNIYLDLIDVENFSNTKDWSLIRFGIEQKLGNILVIRIGSKGDITNLANYTFGLGINLNRFSLSISAFSENIENSDTSLENIKLKYKLTGTLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYN4</accession>
    <name>B8DYN4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nickel-dependent hydrogenase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582502.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352030.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0078"/>
    <dbReference type="EnsemblBacteria" id="ACK41416">
        <property type="protein sequence ID" value="ACK41416"/>
        <property type="gene ID" value="Dtur_0078"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0078"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.79"/>
    <dbReference type="eggNOG" id="COG3259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044556_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYN4"/>
    <dbReference type="OMA" id="QNNLAMN"/>
    <dbReference type="OrthoDB" id="1967820at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="474" mass="53557" checksum="CE9B3FDEA9F37421" modified="2009-03-03" version="1">MEKKITISPVTRIEGHARVTIHLNDDGKVESAFFHVDQFRGFEKFSEGRHFSEMPVITERICGICPISHHLASAKATDEIIGVEIPRTAKLLRELIHMGQIIQSHSMHFFELAGPDLILGWDADPKIRNVVGLIQENPELALKAVKLRKFGQRIIELVAGRRIHPTFAVPGGVNSSLSPSARDEILSGIDEMIGYIKEGIKIAEDFIEKNKELCDEFASFPTGYMGLVKEDGSLELYDGKIRFMDKDGNILKEFKPQYYLRYIGERVEDWTYLKFPYYKPLGYPNGVYRVGPLARLNIADKISTPLANEEFKKFKSINNGKPVEGSIYYHYARLIETVYALERAREILEDPEVMSQNVLKMGEVTNEEGVGVVEAPRGTLIHHYWVDERGTIEKVNLIVSTGHNNWAMSKAVEMVAKAFVDGKNLKEGMLNRVEGAIRCYDPCLSCSTHAIGKMPIVVELYDKDGNIIDVIKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYQ6</accession>
    <name>B8DYQ6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleic acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582524.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352052.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41438">
        <property type="protein sequence ID" value="ACK41438"/>
        <property type="gene ID" value="Dtur_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0102"/>
    <dbReference type="eggNOG" id="COG2405">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115769_0_1_0"/>
    <dbReference type="InParanoid" id="B8DYQ6"/>
    <dbReference type="OMA" id="EATWIET"/>
    <dbReference type="OrthoDB" id="1772839at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021799">
        <property type="entry name" value="DUF3368"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11848">
        <property type="entry name" value="DUF3368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="159" mass="18028" checksum="BE0FF8C7472FDD95" modified="2009-03-03" version="1">MKIVANSSPLIALAKIKKLDLLTYEIYIPRAVFEEITEIGKEYRDELLKWAKEKVLNVENKKAVEYLEIILGKGEAEAIVLSEEIKADAILIDDLKAREIATLRGLKVVGTIGILLNVKRQGTITELKPLLDELIKNGIRISKELYEHALKLANRLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYQ8</accession>
    <name>B8DYQ8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA polymerase beta domain protein region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582526.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352054.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41440">
        <property type="protein sequence ID" value="ACK41440"/>
        <property type="gene ID" value="Dtur_0104"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0104"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_3_2_0"/>
    <dbReference type="InParanoid" id="B8DYQ8"/>
    <dbReference type="OMA" id="YPDEEAQ"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="16"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="114" mass="13140" checksum="E5814B01164D63A2" modified="2009-03-03" version="1">MSKAIDHLEESERIILKELKTKLLELLGSNLEAVILFGSKARGDYDNDSDIDVAIIVNYLDRNLKRNILSIVTNLETEYGIPLSTLVISREEFELLKRRERRIALDIEREGIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYR0</accession>
    <name>B8DYR0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582528.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352056.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0108"/>
    <dbReference type="EnsemblBacteria" id="ACK41442">
        <property type="protein sequence ID" value="ACK41442"/>
        <property type="gene ID" value="Dtur_0108"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0108"/>
    <dbReference type="HOGENOM" id="CLU_205140_0_0_0"/>
    <dbReference type="OMA" id="INLGIWT"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="67" mass="7737" checksum="27AD3C436A8FEB92" modified="2009-03-03" version="1">MEKLLKITKDIFGPMTLKRPIRLLIQILVLFICSATILRIFVDIFSFIIIKLGTWTDKLLKLIGVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYR6</accession>
    <name>B8DYR6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="4 14">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12 14">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">uppP</name>
        <name evidence="15" type="ordered locus">Dtur_0116</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cell inner membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="14">Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="4 14"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582534.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352062.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0116"/>
    <dbReference type="EnsemblBacteria" id="ACK41448">
        <property type="protein sequence ID" value="ACK41448"/>
        <property type="gene ID" value="Dtur_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0116"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.122"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_2_0_0"/>
    <dbReference type="InParanoid" id="B8DYR6"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="14" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6 14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACK41448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="293" mass="32902" checksum="552A5F79CC64BF50" modified="2009-03-03" version="1">MNIWVIILGIVQGITEFLPISSTAHLILIPYLVKIPDFGLSFDVGLHLGTFWAVLIYFLKDWWEFLVSIFKGGEKRRILGLIVLATLPAGILGVFLDPFVEKISQPQVYSFAIWIILIGVISFGIIFLLLEKYSKKNLEIKDLNLKRGLIIGFWQVLSLFPGVSRSGSTISGGMFTGLKRDEATKFSFYLSLPIIGGAVFFKLFHVIKSGDLGSLSLILWGAIVAFIVGILTIHLLLNYVKKASLKVFSYYRFILALAILLAYFNLQVLSLIVFGVAIVYLIFRMVRGEKERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYR9</accession>
    <name>B8DYR9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60 kDa inner membrane insertion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0119</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582537.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352065.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0119"/>
    <dbReference type="EnsemblBacteria" id="ACK41451">
        <property type="protein sequence ID" value="ACK41451"/>
        <property type="gene ID" value="Dtur_0119"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0119"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.125"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036138_4_2_0"/>
    <dbReference type="InParanoid" id="B8DYR9"/>
    <dbReference type="OMA" id="WIMPIMI"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="209" mass="24274" checksum="11BC2464665A5B23" modified="2009-03-03" version="1">MINALANGLGYILELFYKLTGNYGLAIIFLVILVRIILYPLTHAQLKSLFMQQKIQPEIKKIQEKFKDDPQEMNKQIMLLYQQYKINPMMGCLPLLIQFPILIALYQLLLHYKYAVTPQFLWISDLTKPDYILLIIMAIVTYFSGELSSLSAAPEQKNQQRIMNIFTTLLFTGMFLLYKVPAGVMLYWLVSSLFQLLQQVVVFRLHRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYS3</accession>
    <name>B8DYS3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_0123</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582540.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352069.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0123"/>
    <dbReference type="EnsemblBacteria" id="ACK41455">
        <property type="protein sequence ID" value="ACK41455"/>
        <property type="gene ID" value="Dtur_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0123"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.129"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043773_0_0_0"/>
    <dbReference type="InParanoid" id="B8DYS3"/>
    <dbReference type="OMA" id="EVRWTLD"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="55"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="116"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK41455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="394" mass="44248" checksum="5068C0B367FBFD91" modified="2009-03-03" version="1">MKEFLIAKPEEIKSGLNTDAYFLRTEEVLEGIGKNPNVVMELFTKSFPDENYQFGVLLGIYEVAKLLEGLPVDVYAMDEGEIFFPYEPVLQIRGKYKDFARYETTILGFLSFMSGIATKSARVRIAAKDKKIYSFGTRRQHPFLSPVVEYCTYVSGFDGVSNVLGAKYIFKTPVGTMPHALILIIGDEKEAFLAFDQYVDPKIPRIALIDTYGSPTVGALNALEVLKEKLAGVRIDSKDYAYLIKDIKWEFARRGYPNIQIFLSGGLDEYEVEKFYEYADAFGVGTRVANAPVIDFALKIVEVDGNPVAKAGNMPGAKQVQRGNGFNDTIRLFNSELLPEKKPLLKPLIKEGQIVRDFEEIDSIRKRVLNGLNSLPENLKIIKGGKVYIPEFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYU6</accession>
    <name>B8DYU6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OstA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582563.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352092.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0147"/>
    <dbReference type="EnsemblBacteria" id="ACK41478">
        <property type="protein sequence ID" value="ACK41478"/>
        <property type="gene ID" value="Dtur_0147"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0147"/>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_389679_0_0_0"/>
    <dbReference type="OMA" id="WHYAGNI"/>
    <dbReference type="OrthoDB" id="9443at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="708" mass="82318" checksum="CE88A3DD902BE49A" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYY4</accession>
    <name>B8DYY4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582695.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352224.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41610">
        <property type="protein sequence ID" value="ACK41610"/>
        <property type="gene ID" value="Dtur_0287"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0287"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.302"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030024_2_1_0"/>
    <dbReference type="InParanoid" id="B8DYY4"/>
    <dbReference type="OMA" id="MSFQSHT"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="114"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="319" mass="37268" checksum="125E4F5B68AA2073" modified="2009-03-03" version="1">MGRDKNGIIKSIIKYISEVLILIFVIFHLSYAYVEPRADINSKSEFNPLFRVYYSNAVIVLTYHAVDRKILGPISLSPDLFEKHMEYLKYMGFHFITPDLLRRFMEGREDVPDNAVLITFDDGYENFYTNAYPILKKFHIPAINFVIVSKIGKNGAFPHLKWDEMREMLKSGLIYFGSHSYDSHYLIKIGIFKKAPALVGRKFELFGYKESEEEYETRIAFDLWYSKVLLENNLGISVKDFCFPYGAYNEKLLEIGKNLGYEVFYTTEKGINKTAKSKYILIKRLNAGSYNMTFSRFQALLFKYIIPHKVQSIPRKVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ23</accession>
    <name>B8DZ23_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582734.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352263.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0335"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41649">
        <property type="protein sequence ID" value="ACK41649"/>
        <property type="gene ID" value="Dtur_0335"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0335"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038143_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZ23"/>
    <dbReference type="OMA" id="GWLGKPH"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="36"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="346" mass="40549" checksum="AB6C4D707C5B6838" modified="2009-03-03" version="1">MRGVLYFLSWLIGWVYYKSLRFLKKEGEISGEYKVSVIIPARNEEKNLDKLLYLLQKQTYKPYEVIVVNDNSEDNTEEVAKRYGVKVVSLYEDPPEGWVGKNWAIWNGYLESRGEILLFLDADVEPREEFIEVMLSNYEKYGGLISCWPYQRFEKFYEHLNFIFNIGAVITMCAIKKEGAFGPSMMISREYYEKVGGHKEVRDKVVEDLHFGNLCIKKGVPVNNFLGGEYIKFRMYPKGLRDLIEGFSKNSSQGVVSLSFTKFLYLLMWFYGVFGSFAFENLINLCYLLFSFQLYIISRRLGDYSIIDSIIYPIHFMFFITVLLYSTFKTFLFKSVSWKGRKINVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ35</accession>
    <name>B8DZ35_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase group 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582746.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352275.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0349"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41661">
        <property type="protein sequence ID" value="ACK41661"/>
        <property type="gene ID" value="Dtur_0349"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0349"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825701_0_0_0"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="166"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="336" mass="39314" checksum="D634A9BBC7FB6917" modified="2009-03-03" version="1">MQNGKNIFFLYYIPHTFHKSLAQAVRAKDLDILCSNKKPLRRIFSYVKFSLNSSPYDILLCEGTFLIPALFKILPFKKFKKFIINISADPKLYYIKTKNMNLFKGFMHSLAIPQVDLFICIGEMERDLLREISPRAKFIVAYPFIEEERYNHLLNLPIKERFNHNILFVGNGPDHFCKGIDLLINTFKIVKQEFQDAELFILGNWNKDIKEKFYYQGVHFVGFSQIYEYIEKSSLYLHLGRGEAFSISTIEVLLGGLPAIVSEYTGAKEIVKKLRDDFVVPLDSKRAAEKVIEYFQLTEDDKKDLSLRAKELGKRFKKEIVLSEFINKWNSVMRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ37</accession>
    <name>B8DZ37_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582748.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352277.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0351"/>
    <dbReference type="EnsemblBacteria" id="ACK41663">
        <property type="protein sequence ID" value="ACK41663"/>
        <property type="gene ID" value="Dtur_0351"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0351"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_0"/>
    <dbReference type="InParanoid" id="B8DZ37"/>
    <dbReference type="OMA" id="CEGFISL"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008743">
        <property type="term" value="F:L-threonine 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="313" mass="35978" checksum="666FD1E4A105C72C" modified="2009-03-03" version="1">MSKILITGALGVIGVFLYDSLKKDGFEIIGIDQKITDYSDYIRADVTHFEDLWKVFKKEKISTVIHLAGEVGRLIGEEYPQRMVYVNNVGLLNIISLCLEYNSRLIYFSTSEVYGKLFNEGKEVKEEDIELKGNPFITTNIYALSKLYGEAIVKHYVDNYGLKALTIRPFMVYGPGEYSNRYRSAISIFVYNALNNKPITVHKGAIRAWCYISDFIDGVKLLLDYPITEKYEAFNIGSDEYHTMEEVANIIIEEVGGDFENLKIIDPPSKFLSLVKRFSIEKIKNLGYKPKISFREGVREVIKWQKEVLKNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ82</accession>
    <name>B8DZ82_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582900.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352429.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0522"/>
    <dbReference type="EnsemblBacteria" id="ACK41815">
        <property type="protein sequence ID" value="ACK41815"/>
        <property type="gene ID" value="Dtur_0522"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0522"/>
    <dbReference type="eggNOG" id="COG4552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050659_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZ82"/>
    <dbReference type="OMA" id="WNEGRWR"/>
    <dbReference type="OrthoDB" id="1497065at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034069">
        <property type="term" value="F:aminoglycoside N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030649">
        <property type="term" value="P:aminoglycoside antibiotic catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041380">
        <property type="entry name" value="Acetyltransf_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025559">
        <property type="entry name" value="Eis_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17668">
        <property type="entry name" value="Acetyltransf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13530">
        <property type="entry name" value="SCP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SSF55718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="387" mass="45536" checksum="9AB8C6ABF3DD3776" modified="2009-03-03" version="1">MEIIRLNPSYMDELIELWSQSFAFPYEQVSTWVNEKSIRNCIGAIENNRLVSALNIIPMEGYVRGELFSFSGIGGVATFPEKRGKNYVHYLLKESIRISKESGSAFSSLYPFSFEFYRNFGWELGGFQKRYKIKTYSIPKFSEMEKVKRIPLEDWKIIKPVYDKHSKNFSGTIKRTEERWESIIFRTRTLTYLYIYEDKDIEGYLLYSVEKTNINKVVVREMICLNNSAYRGFLSLFSRQAMTIEEVEWTVPLNDLLPFILPNPRGECLVEPTFMIRVIDVEKALSSLKYDENIKDKIVIKIKDEHANWNHGIWEIEIENGKVKLEKKENLEPEIELNINILSQIIAGTISSQKAYELGYIEVNNFNSLHKFNNLFPEYPTFCWDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ83</accession>
    <name>B8DZ83_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Chitinase</fullName>
            <ecNumber evidence="6">3.2.1.14</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582901.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352430.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0523"/>
    <dbReference type="CAZy" id="GH18">
        <property type="family name" value="Glycoside Hydrolase Family 18"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41816">
        <property type="protein sequence ID" value="ACK41816"/>
        <property type="gene ID" value="Dtur_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0523"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.556"/>
    <dbReference type="eggNOG" id="COG3325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002833_14_2_0"/>
    <dbReference type="InParanoid" id="B8DZ83"/>
    <dbReference type="OMA" id="NPMTYDF"/>
    <dbReference type="OrthoDB" id="1081028at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="SSF54556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="5">
        <location>
            <begin position="4"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="372" mass="43609" checksum="AE1895E7C3B657C2" modified="2009-03-03" version="1">MSPKRIIAYFPEWKVKDEYLNYSVEDIPWKLLTHINYAFAKIVEGKLHPIEEDLFYSNMEKIKEYKKEYRDVKVLISVGGWTDSGEFSDVALNEENRKKFAKSALELVKEFNLDGVDIDWEFPVSGGLPTNKARPEDKENFTLLLKTLRDVLKEENENYLLTIAAPASYTQIHNTEPDKYHIFLDFINLMTYDFHGIWDKYTNHHSPLYGNPKDPDEKSRERANCDFAVKEYLKFGIPPEKIVLGVPFYGKGWICEDDGHNGLFAKVKGIPYGIFDNEDHPSGSNPFFFIKGVIENDPNYIKFRDKYAKVPWLWNPKEKIMYSYDDEESILEKCNYVIKNNLGGIMFWEVTQDYPFKGHTLVKLIHQKFWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ86</accession>
    <name>B8DZ86_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein-tyrosine phosphatase, low molecular weight</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582904.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352433.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0526"/>
    <dbReference type="EnsemblBacteria" id="ACK41819">
        <property type="protein sequence ID" value="ACK41819"/>
        <property type="gene ID" value="Dtur_0526"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0526"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.559"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_2_0"/>
    <dbReference type="InParanoid" id="B8DZ86"/>
    <dbReference type="OMA" id="DNAKERC"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="1">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="152" mass="17503" checksum="B153DEDBC7A4C6B7" modified="2009-03-03" version="1">MIKKRILFICTHNSARSQMAEGIVNALYRDRYEAYSAGTEPKGVNPLAIEVLKEIGIDISHHRSKSIEEFKGQEFDYVVTVCDNAKENCPFFPGGKRYIHRGFMDPASVEGSYEEKLSAFRKVRDEILNWVKEFFIENKEEGVSFFTPLNKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZC9</accession>
    <name>B8DZC9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide biosynthesis protein CapD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582947.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352476.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0573"/>
    <dbReference type="EnsemblBacteria" id="ACK41862">
        <property type="protein sequence ID" value="ACK41862"/>
        <property type="gene ID" value="Dtur_0573"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0573"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.609"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_0_0"/>
    <dbReference type="InParanoid" id="B8DZC9"/>
    <dbReference type="OMA" id="IIIAMPS"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="294"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="633" mass="72502" checksum="CE64F06D219F9ACA" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZE1</accession>
    <name>B8DZE1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Undecaprenyl-phosphate galactose phosphotransferase</fullName>
            <ecNumber evidence="4">2.7.8.6</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.6" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582959.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352488.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0586"/>
    <dbReference type="EnsemblBacteria" id="ACK41874">
        <property type="protein sequence ID" value="ACK41874"/>
        <property type="gene ID" value="Dtur_0586"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0586"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.621"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_4_0"/>
    <dbReference type="InParanoid" id="B8DZE1"/>
    <dbReference type="OMA" id="QVQNIDM"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047360">
        <property type="term" value="F:undecaprenyl-phosphate galactose phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="3">
        <location>
            <begin position="7"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="206" mass="23825" checksum="4EDACAB5790E2207" modified="2009-03-03" version="1">MRSYFLKRIIDIIGSLIGLVVASPIIVVISIIIYITMGRPIFFKQVRPGLKGKPFVIYKFRTMLDLRDENGNLLPDEKRLTTIGKFLRSTTLDELPEFWNVLKGDMSLVGPRPLLMEYLDRYTPEQARRHNVKPGMTGWAQINGRNAITWEEKFKLDVWYVDNWNILLDLKIIFLTILKVLKREGISAEGHATMPEFMGEEVINSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZF6</accession>
    <name>B8DZF6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0601</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582974.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352503.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0601"/>
    <dbReference type="EnsemblBacteria" id="ACK41889">
        <property type="protein sequence ID" value="ACK41889"/>
        <property type="gene ID" value="Dtur_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0601"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.637"/>
    <dbReference type="eggNOG" id="COG2135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035990_6_2_0"/>
    <dbReference type="InParanoid" id="B8DZF6"/>
    <dbReference type="OMA" id="FPARYNI"/>
    <dbReference type="OrthoDB" id="1718602at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="234" mass="27469" checksum="755B431EE3E4E048" modified="2009-03-03" version="1">MCGRFTLIQIEKIPTRFNAQIIGEINLRKRYNISPNQPVPIVFQESPNKVEEMIWGLIPHWAEDPKIGNSLINARAESLLKKPAFKESFLRRRCLIPADGFYEWKKMEKEKIPYYIKMKNSSLFAFAGLYDIWKSPDGKLIKTFTIITTEPNDLVKEIHNRMPVILRREYEEIWVNKEESDIKKLQSLLAPYPAEEMEAYPVSKKVNNPSYDSEELIKPVKIYIIKKDQTSFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZF8</accession>
    <name>B8DZF8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">M6 family metalloprotease domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582976.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352505.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0603"/>
    <dbReference type="EnsemblBacteria" id="ACK41891">
        <property type="protein sequence ID" value="ACK41891"/>
        <property type="gene ID" value="Dtur_0603"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0603"/>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_295398_0_0_0"/>
    <dbReference type="OMA" id="DIWSHAS"/>
    <dbReference type="OrthoDB" id="461923at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025965">
        <property type="entry name" value="FlgD_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008757">
        <property type="entry name" value="Peptidase_M6-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13860">
        <property type="entry name" value="FlgD_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05547">
        <property type="entry name" value="Peptidase_M6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03296">
        <property type="entry name" value="M6dom_TIGR03296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="478"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1024" mass="114392" checksum="00178105C484BB0E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZG3</accession>
    <name>B8DZG3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRISPR system Cms protein Csm5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CRISPR type III A-associated protein Csm5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0608</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This subunit might be involved in maturation of a crRNA intermediate to its mature form.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated Csm5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582981.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352510.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0608"/>
    <dbReference type="EnsemblBacteria" id="ACK41896">
        <property type="protein sequence ID" value="ACK41896"/>
        <property type="gene ID" value="Dtur_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0608"/>
    <dbReference type="eggNOG" id="COG1332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036878_3_0_0"/>
    <dbReference type="InParanoid" id="B8DZG3"/>
    <dbReference type="OMA" id="PIFIGCG"/>
    <dbReference type="OrthoDB" id="1989826at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010173">
        <property type="entry name" value="CRISPR-assoc_Csm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38007">
        <property type="entry name" value="PTHR38007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01899">
        <property type="entry name" value="cas_TM1807_csm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="381" mass="44546" checksum="A7A581241D227262" modified="2009-03-03" version="1">MKIKIQVITPTLIRSGEVISNVSECVIEDNRLKIIDKEKLLNMFKDKNLKNFVNELSSMITNQRENIKDLLNKYKIPIDEVIKYSLEIKSKIERNNESSRQPSRNIYMPILTGENAYIPGSTLKGVIRNALLFYALEKDKSKQNAFLEKTAERIKSEIPKKNKPYIGEDILRTNEKDIHTDIMKYIIVRDSSLVPLSELNVYVIRRIPHQKLSQYVIAIPAGKEFDTEIIIKKDMISNIPTEWKDFFEKEPEEKLWSALKNYSLKLSKKEQELLSELSSKKYSNNEEAKNTINDLIEHYNKVQQELKEQEQKNKEVIYLPIGFGKTYYYNSLGYFIKTEQLKNLGIIRRNVDPQIYPSTRWAVQIGKKLFPLGGVYIIRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZG6</accession>
    <name>B8DZG6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRISPR system Cms protein Csm2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CRISPR type III A-associated protein Csm2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This subunit may be involved in monitoring complementarity of crRNA and target RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated Csm2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582984.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352513.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0611"/>
    <dbReference type="EnsemblBacteria" id="ACK41899">
        <property type="protein sequence ID" value="ACK41899"/>
        <property type="gene ID" value="Dtur_0611"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0611"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.648"/>
    <dbReference type="eggNOG" id="COG1421">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1746733_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZG6"/>
    <dbReference type="OMA" id="PEEGWRS"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010149">
        <property type="entry name" value="CRISPR-assoc_prot_Csm2_III-A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03750">
        <property type="entry name" value="Csm2_III-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01870">
        <property type="entry name" value="cas_TM1810_Csm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="149" mass="17729" checksum="C3E7124998026DA9" modified="2009-03-03" version="1">MRDNQSSRQQNTKTPEELWRERVESVLGKDYVQKILAFGEDLDINEFKKFNERIQNFIRERTEGITSSRLRKVYDLIKKAKNISELLYTIPYLAYMVGREESKRRKEALGELYVVLKEAIEKAENDKHVKNIQKFTEALVAYQKFYGKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-06-13" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZH3</accession>
    <name>CAS2_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cas2</name>
        <name type="ordered locus">Dtur_0618</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582991.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352520.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8DZH3"/>
    <dbReference type="SMR" id="B8DZH3"/>
    <dbReference type="STRING" id="515635.Dtur_0618"/>
    <dbReference type="EnsemblBacteria" id="ACK41906">
        <property type="protein sequence ID" value="ACK41906"/>
        <property type="gene ID" value="Dtur_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0618"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.655"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_0_1_0"/>
    <dbReference type="InParanoid" id="B8DZH3"/>
    <dbReference type="OMA" id="LTHVQNS"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0051">Antiviral defense</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000417710" description="CRISPR-associated endoribonuclease Cas2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <sequence length="87" mass="10602" checksum="BC862D310FBE1D7D" modified="2009-03-03" version="1">MYVIMVYDVNQRRINKVLNTARKYLEWIQNSVLEGEITEAKFEMLKREIEIIINEEEDSVIFYIMRTTKYSERQILGIEKNKREQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZI8</accession>
    <name>B8DZI8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583006.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352535.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0633"/>
    <dbReference type="EnsemblBacteria" id="ACK41921">
        <property type="protein sequence ID" value="ACK41921"/>
        <property type="gene ID" value="Dtur_0633"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0633"/>
    <dbReference type="HOGENOM" id="CLU_1072540_0_0_0"/>
    <dbReference type="OMA" id="NKMEIRR"/>
    <dbReference type="OrthoDB" id="2164518at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="259" mass="30127" checksum="F583F94785CA8528" modified="2009-03-03" version="1">MRNVINIVKYEILGKKNAYLISLLTLIGLVFTIYARLNSTVMNRDDLSLIIFVFLFLVFLVGIILIAISNLMDINSKDLNYLSFTLPLKPSVLFLKRMIIYLIELLSFLIVIIFLTFFILRLYNTSFSHAVINYFSSYGAILFLDFLFGNVIAFFLVSLMIIAKKLPYENRILKIIIYIGCILYLLYKGHLNNFLIKIFPQKLPIFIPAFDYNISGKLGIGFSVPKIEYFVVEVILRILILAIIIFLYNRLLNKMEIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZJ5</accession>
    <name>B8DZJ5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate-binding family 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583013.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352542.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0643"/>
    <dbReference type="CAZy" id="CBM9">
        <property type="family name" value="Carbohydrate-Binding Module Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41928">
        <property type="protein sequence ID" value="ACK41928"/>
        <property type="gene ID" value="Dtur_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0643"/>
    <dbReference type="eggNOG" id="COG3693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075287_0_0_0"/>
    <dbReference type="OMA" id="EESIYVW"/>
    <dbReference type="OrthoDB" id="101882at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010502">
        <property type="entry name" value="Carb-bd_dom_fam9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06452">
        <property type="entry name" value="CBM9_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carb-bd_dom_fam9" evidence="1">
        <location>
            <begin position="38"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="215" mass="24839" checksum="FC294B85BD505443" modified="2009-03-03" version="1">MRRSRLFILITLLVIGLFLSLAFGQTLTATAKYGKPKIDAEMDEVWKNAEEYITDRYVQGVKGKVAYAKFRVLWDEESIYVWAEVYDSLLNKDSTNPWEQDSLEIFVDEGNEKATSYDKNDAQYRVNFENVQSYGTNASRDYFVTATKKTDFGYIVEAQVKMRTRKLNEGDVIGFDVQVNDADRFGSRVGIIAWNETENENWRNPSYLGNLKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZL7</accession>
    <name>B8DZL7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0665</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583035.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352564.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0665"/>
    <dbReference type="EnsemblBacteria" id="ACK41950">
        <property type="protein sequence ID" value="ACK41950"/>
        <property type="gene ID" value="Dtur_0665"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0665"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZL7"/>
    <dbReference type="OMA" id="QIFKHHC"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="109"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="320" mass="36082" checksum="70335A86872F9566" modified="2009-03-03" version="1">MGLLKYILRRLFTIFVSIVVVIIITYVLMWLAPGEFFNIAQFQASAGKVATLTPEQLQILIKGFEEKYGLNVPLWKQVWNYLKDAFRFKFGPSFSNPNEPIEVQIARRFPVTFTLAILAMALAVIVGIPLGVLAALRRNTWVDYITMFFSMIGSIIPAYLIGVIMVIIFSVYLRLLPTSGWETPKQMIMPVITVALGPMAIIARFTRSSLLDVLNQDYIRTAYAKGGTDRAVIMRHALRNSLLPVVTVIGPQLAFLFTGTVWIENLFRVPGLGQLFVNAASMRDYPLLVTSTFILSLSVMLMNLLVDIIYAFLDPRIKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZL8</accession>
    <name>B8DZL8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0666</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583036.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352565.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0666"/>
    <dbReference type="EnsemblBacteria" id="ACK41951">
        <property type="protein sequence ID" value="ACK41951"/>
        <property type="gene ID" value="Dtur_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0666"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.704"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZL8"/>
    <dbReference type="OMA" id="VHMRESA"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="290" mass="32214" checksum="0B799329807DC0DB" modified="2009-03-03" version="1">MEVALKQKTKRVSYWSAAWRRFKRNKMAVAGLIYIIIITIAAIFTPWIAPYPYDEPHYAHTFEPPSARFWWGTDDLGRDMFSRNLYAMRNALLIGFGSQIVVLIIGVIIGSIAGFRGGAVDTFLMRITDIMYAFPTFLFNVILVTVMGRGLFTILVAVGLTGWAGMARLVRGMVMYLKHADFVEAARALGAKDSYIIRRYILPNMLGPIIVSLAFGIPNGIWVESGLALIGMGVRPPMPSWGNMIGAGIGYIMAFPHMVIFPVLTFAITLLAFTYVGDGLRDAFNPRSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZN4</accession>
    <name>B8DZN4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase M42 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_0682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583052.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352581.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0682"/>
    <dbReference type="MEROPS" id="M42.007"/>
    <dbReference type="EnsemblBacteria" id="ACK41967">
        <property type="protein sequence ID" value="ACK41967"/>
        <property type="gene ID" value="Dtur_0682"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0682"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.720"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZN4"/>
    <dbReference type="OMA" id="MHTPVEM"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK41967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="335" mass="37793" checksum="A5071DCBAB94A54F" modified="2009-03-03" version="1">MEVKEILKNLSNLDGPSGYEFPVIKYIKDVAEKIAPVKTLIDNHGNLIVRKKGDGRKIALFAHTDEIAFVITKKEFGNYFRIHTFGGVDPKVVISQRLRIHTKEGISYGIVGMLEPHLQNEEIRQKNITFDDLFIDVLDKSDSVQIGDLATFDSEAFDLNERYIAGKALDNRASCATLLYTLELLNQFIVNADIYFVFSVREEDGVSGAVNAAYKINPDLAIVLDVTHGDILRPSYPKIETGKGPVLDIGPMVNYEYFDKIKNLAEKLSVNYQIEPNGDHSHTDTDRIQITREGIPTLLISIPLRYMHTPYEVVNIRDMEETARLLSFFLARGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZS0</accession>
    <name>B8DZS0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_0718</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583088.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352617.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0718"/>
    <dbReference type="EnsemblBacteria" id="ACK42003">
        <property type="protein sequence ID" value="ACK42003"/>
        <property type="gene ID" value="Dtur_0718"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0718"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.755"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_0"/>
    <dbReference type="InParanoid" id="B8DZS0"/>
    <dbReference type="OMA" id="CECLNLP"/>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="316"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="251"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="433" mass="48816" checksum="F160E24F4994A9EC" modified="2009-03-03" version="1">MKKIGIIGIGYIGLVIVLGLVDFGNQVICLDIDDEKIEQLRKGISPIKEKDIDELLRRNIEKNRIKFTKDIQELISNSEIIFICVNTPPKEDGSVDLSQVISVSESLAKNLKDKKIIAIKSTIPIGTLEKINQIFENYGKKKNQDFEIAFIPEFLREGNAVYDFYNPSRIVIGAENPETIEELKKLFSPLNAPFIITSPNAAILIKYASNAFLAMRISFINEIANIAERFGIDIQEVIEGMKYDKRIGKDYLQPGIGFGGPCLGKDLMGLIKMAEKQGYQPNLLISILEKNEHQIRQIIYKIKSFLGEFLDGQIIRVLGLTFKPDTNDVRNSLALRITKVLKNDGAKIKASDPLGMEEAKKEINDVEYCDNPYDVAQDSNCLVILTGWKEFKELDFLKIKRVMKAPIIIDGVNLLDPQIIKNMGFIYKGVGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZU1</accession>
    <name>B8DZU1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583109.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352638.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0742"/>
    <dbReference type="EnsemblBacteria" id="ACK42024">
        <property type="protein sequence ID" value="ACK42024"/>
        <property type="gene ID" value="Dtur_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0742"/>
    <dbReference type="HOGENOM" id="CLU_1233425_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZU1"/>
    <dbReference type="OMA" id="CYVIEIG"/>
    <dbReference type="OrthoDB" id="2112445at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="219" mass="25989" checksum="7ECDD512141D9EAD" modified="2009-03-03" version="1">MKTARFTTLILLLLLLVISLSYAISYEEILERMSSFYRNLQSFYCILEVYNKAGNTEENVTYEYYFQKPDKLRLEVLEGKDKGTTIVYQNNRIRYKKGGVLSFIPLSLNIDDPIVLSIRKGRINELTFDYILDILSKYKPKSIKEVSIFGYNCYVIEIGESKDRLYNYSMQRIYVEKNTFVPIQLEQYENINGQNELVHKRIYRNFKINLPIDEKIFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZX2</accession>
    <name>B8DZX2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583140.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352669.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0773"/>
    <dbReference type="EnsemblBacteria" id="ACK42055">
        <property type="protein sequence ID" value="ACK42055"/>
        <property type="gene ID" value="Dtur_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0773"/>
    <dbReference type="eggNOG" id="COG1430">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097039_0_2_0"/>
    <dbReference type="InParanoid" id="B8DZX2"/>
    <dbReference type="OMA" id="TMWMKNT"/>
    <dbReference type="OrthoDB" id="1934378at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003795">
        <property type="entry name" value="DUF192"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038695">
        <property type="entry name" value="Saro_0823-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37953">
        <property type="entry name" value="PTHR37953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02643">
        <property type="entry name" value="DUF192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="162" mass="18940" checksum="3C4C43EA390F1E79" modified="2009-03-03" version="1">MKKRTVLFFIVFIVLLVITMFSLFSFGKGNLSKFPRGKLLITQEGRSLQIPIEIADKEELWTLGLMYRKSIPWEYGMLFVFPYDTNAGFWMKDTYVPLDIAFISADGIIFNIQRMEPCKDQENCPVYYSPKPYRYALEVKAGFFEKYGFSLGAKIKYWKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZX6</accession>
    <name>B8DZX6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583144.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352673.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0777"/>
    <dbReference type="EnsemblBacteria" id="ACK42059">
        <property type="protein sequence ID" value="ACK42059"/>
        <property type="gene ID" value="Dtur_0777"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0777"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122749_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZX6"/>
    <dbReference type="OMA" id="LRIKGMI"/>
    <dbReference type="OrthoDB" id="1613263at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="159" mass="19014" checksum="D491FF62C78DB39A" modified="2009-03-03" version="1">MLRMFSSQDLLEMAMHIEEEGERFYKLMESKVEDENLKRLFNYLAVEEQRHALTFKEIYSQIEKEGFISAYPDEEANKYLHAFVDSQVFIDWDKLSSRTVWNLMEVLDLAIGLEKDSILFYYEMEKYIPEKDKVVLHEIIKQEKAHLSQLTEFKKGIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZY5</accession>
    <name>B8DZY5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="5" type="ordered locus">Dtur_0787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583153.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352682.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0787"/>
    <dbReference type="EnsemblBacteria" id="ACK42068">
        <property type="protein sequence ID" value="ACK42068"/>
        <property type="gene ID" value="Dtur_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0787"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.826"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_0"/>
    <dbReference type="InParanoid" id="B8DZY5"/>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009041">
        <property type="term" value="F:uridylate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="9"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="207" mass="24067" checksum="BA9A96AA2E7981CC" modified="2009-03-03" version="1">MKNNLFITFEGIDGSGKTTQALLLKEHFESKGYKVHLTREPGGTDVGNKIREILLNPAFSINYWTEAFLYLASRVENTINIIKKLKENYVVICERYADSTLAYQGYGRNLPLELLVEMNQIATFGLKPNLTILIDLDPELALRRKKSFDRIERENIEFYYKVRKGYLEIAKKEKERFIIIPGDLSKGEIFKRIVEEIERKNLGEVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>B8E012</accession>
    <name>B8E012_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352709.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0814"/>
    <dbReference type="EnsemblBacteria" id="ACK42095">
        <property type="protein sequence ID" value="ACK42095"/>
        <property type="gene ID" value="Dtur_0814"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0814"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_299915_0_0_0"/>
    <dbReference type="InParanoid" id="B8E012"/>
    <dbReference type="OMA" id="GRINWQD"/>
    <dbReference type="OrthoDB" id="754526at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="1101" mass="125012" checksum="6C04D9176E49D103" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E024</accession>
    <name>B8E024_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583191.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352721.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0826"/>
    <dbReference type="EnsemblBacteria" id="ACK42107">
        <property type="protein sequence ID" value="ACK42107"/>
        <property type="gene ID" value="Dtur_0826"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0826"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_0"/>
    <dbReference type="InParanoid" id="B8E024"/>
    <dbReference type="OMA" id="GWHHARV"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="315" mass="35519" checksum="C4DD7FC26F487F23" modified="2009-03-03" version="1">MSKVKVGVVGVGYLGQHHVRIFNEIPDVELVGICDINLKRAKEIASIYNVPFVTDDYRDLLNRVEAVSIVTPTTSHFQIAKDFLEKGIHTFIEKPVTHSLREAEILLDIASGKDLVLQVGHIERFNPAIQELKKYVKDPFYIEARRMGPFDGRSTDVGVVMDLMIHDLDILFYVLGKNRRILEISGIGYSIYTPYEDFATVNILFEGEILVNLIASKVSPKKLRKLDIHEKNGDQIIVDYIEQSISVVHGGARHIESALESPVLEREEPLRLELTHFVKCIIEGKDPEVTLEDGKLALALATEILKELKIIDLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E054</accession>
    <name>B8E054_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583221.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352751.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0856"/>
    <dbReference type="EnsemblBacteria" id="ACK42137">
        <property type="protein sequence ID" value="ACK42137"/>
        <property type="gene ID" value="Dtur_0856"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0856"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.895"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3833">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340630_0_0_0"/>
    <dbReference type="InParanoid" id="B8E054"/>
    <dbReference type="OMA" id="QTFYKIV"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015423">
        <property type="term" value="F:ABC-type maltose transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042956">
        <property type="term" value="P:maltodextrin transmembrane transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015768">
        <property type="term" value="P:maltose transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="710"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="534"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="167"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="288"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="746" mass="86966" checksum="5E928F9650470A95" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E065</accession>
    <name>B8E065_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide TPR_2 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583232.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352762.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0867"/>
    <dbReference type="EnsemblBacteria" id="ACK42148">
        <property type="protein sequence ID" value="ACK42148"/>
        <property type="gene ID" value="Dtur_0867"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0867"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1364399_0_0_0"/>
    <dbReference type="InParanoid" id="B8E065"/>
    <dbReference type="OMA" id="DWQILYR"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="76"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="110"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="200" mass="23690" checksum="95BE0E11C913BC23" modified="2009-03-03" version="1">MKKDFTDLLRKADDLKQRGKLYKAITLYEEILSAIDDNELLEWLRITLADLYFWVKEFDKAKNLVMDNINQNPQEAFNYYFMGFLLIGEGKFCEAKEYFNMACEIEPENPEYLRGLGLVEFLLDNFDTAENILREVLKRDPENSAARDNLIELLIRIGKVEEAEKEISEFRRKDPKDWQILYRVQELRNKKEEIKKGGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E069</accession>
    <name>B8E069_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mltG</name>
        <name evidence="8" type="ordered locus">Dtur_0871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352766.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0871"/>
    <dbReference type="EnsemblBacteria" id="ACK42152">
        <property type="protein sequence ID" value="ACK42152"/>
        <property type="gene ID" value="Dtur_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0871"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.909"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_2_2_0"/>
    <dbReference type="InParanoid" id="B8E069"/>
    <dbReference type="OMA" id="IAMPGKA"/>
    <dbReference type="OrthoDB" id="708179at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="339" mass="39206" checksum="865862785E7557A1" modified="2009-03-03" version="1">MNNFSLYFLLIFSLLVFIGFLVYLYLSSPKSKIEREIEVYIPEGSSAYKVADILLDNSLIKSKEVFIATLKLMGKDKGLKSGYYILSPSFSMFDIIDILTQGKGLRVKITIPEGSSLKDMAHLFSEKLALSKEKFITLCKDENFIDSVMKDYKNYFSSYKSLKTLEGYLYPSTYYFNKGIKEEDIIKFLIKEFFNQINVHIPEYKERLKSLNLSFNDWIILASIVEKEAKVDQERPLIAGVFLNRLKKGYKLQSCATVEYVYDFKKSVLLYKDLEIDSPYNTYIYYGLPPSPICSPSLNSLKAVLYPQGDYLFFVAKGDGTHIFTKTYEEHLKAQEFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E075</accession>
    <name>B8E075_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal methylation motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583242.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352772.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0877"/>
    <dbReference type="EnsemblBacteria" id="ACK42158">
        <property type="protein sequence ID" value="ACK42158"/>
        <property type="gene ID" value="Dtur_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0877"/>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_7_1_0"/>
    <dbReference type="InParanoid" id="B8E075"/>
    <dbReference type="OrthoDB" id="2044924at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="2">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="142" mass="15518" checksum="D08ACA5423683C53" modified="2009-03-03" version="1">MRREKGFTLIELMVVIVIIAILAAVALPNFMGATERARESAVRSAVKSIQTALEIYATDNQGYYPDYIYTLKNGNYLPGGKFPNNPATNTEYGFTANNNDSGESAYKIVYTVSTDHASYTITGYGKDNQKIVIQVSSAGTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>B8E080</accession>
    <name>B8E080_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA polymerase I</fullName>
            <ecNumber evidence="2 11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">polA</name>
        <name evidence="14" type="ordered locus">Dtur_0882</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the DNA polymerase type-A family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 11"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583247.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352777.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0882"/>
    <dbReference type="EnsemblBacteria" id="ACK42163">
        <property type="protein sequence ID" value="ACK42163"/>
        <property type="gene ID" value="Dtur_0882"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0882"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.920"/>
    <dbReference type="eggNOG" id="COG0258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004675_0_0_0"/>
    <dbReference type="InParanoid" id="B8E080"/>
    <dbReference type="OMA" id="NRPPMPD"/>
    <dbReference type="OrthoDB" id="1220182at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd09898">
        <property type="entry name" value="H3TH_53EXO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020046">
        <property type="entry name" value="5-3_exonucl_a-hlix_arch_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019760">
        <property type="entry name" value="DNA-dir_DNA_pol_A_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020045">
        <property type="entry name" value="DNA_polI_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018320">
        <property type="entry name" value="DNA_polymerase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002298">
        <property type="entry name" value="DNA_polymerase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10133">
        <property type="entry name" value="PTHR10133"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01367">
        <property type="entry name" value="5_3_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02739">
        <property type="entry name" value="5_3_exonuc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00868">
        <property type="entry name" value="DNAPOLI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="SSF47807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00593">
        <property type="entry name" value="pola"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00447">
        <property type="entry name" value="DNA_POLYMERASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 11 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="53EXOc" evidence="12">
        <location>
            <begin position="19"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="POLAc" evidence="13">
        <location>
            <begin position="613"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ACK42163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="855" mass="99241" checksum="7DE409656091724E" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>B8E086</accession>
    <name>B8E086_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidoglycan glycosyl transferase</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583613.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353145.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1253"/>
    <dbReference type="EnsemblBacteria" id="ACK42531">
        <property type="protein sequence ID" value="ACK42531"/>
        <property type="gene ID" value="Dtur_1253"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1253"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1293"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_0_0"/>
    <dbReference type="InParanoid" id="B8E086"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PBP_dimer" evidence="3">
        <location>
            <begin position="42"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="203"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="515" mass="58674" checksum="714FA3446C030205" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0F1</accession>
    <name>DEOC_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyribose-phosphate aldolase</fullName>
            <shortName evidence="1">DERA</shortName>
            <ecNumber evidence="1">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphodeoxyriboaldolase</fullName>
            <shortName evidence="1">Deoxyriboaldolase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">deoC</name>
        <name type="ordered locus">Dtur_1322</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583678.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353210.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0F1"/>
    <dbReference type="SMR" id="B8E0F1"/>
    <dbReference type="STRING" id="515635.Dtur_1322"/>
    <dbReference type="EnsemblBacteria" id="ACK42596">
        <property type="protein sequence ID" value="ACK42596"/>
        <property type="gene ID" value="Dtur_1322"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1322"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1367"/>
    <dbReference type="eggNOG" id="COG0274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0F1"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="OrthoDB" id="1227369at2"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_1000117544" description="Deoxyribose-phosphate aldolase">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with acetaldehyde" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00114"/>
        </source>
    </evidence>
    <sequence length="219" mass="24204" checksum="D9313B151D8C757E" modified="2009-03-03" version="1">MNRYELAQKIDHTLLRPNISLLDIERLCNEAKEFGFYSVCINPYYIPYAKELLKDTKVKICTVIDFPLGASTTSMKVYQVRESLKLGAEEFDMVINIGALKDKKRDYLISEIREVVKAAEGKVVKVIIETCYLTDEEKIYATEIIKEGGAHFVKTSTGFGPQGATVQDVRLLKSIAGNDLKVKASGGIRTFEQALEMINAGADRIGTSSGVSIINGLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0F8</accession>
    <name>B8E0F8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PhoH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583685.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353217.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1329"/>
    <dbReference type="EnsemblBacteria" id="ACK42603">
        <property type="protein sequence ID" value="ACK42603"/>
        <property type="gene ID" value="Dtur_1329"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1329"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1374"/>
    <dbReference type="eggNOG" id="COG1702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051654_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0F8"/>
    <dbReference type="OMA" id="PAQMKMV"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoH" evidence="3">
        <location>
            <begin position="87"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="296" mass="33790" checksum="050F9012F26EDF64" modified="2009-03-03" version="1">MERSLLRTEIIIPKDVESYREEILNNIEKIEEIDNVKIKVEDNKLVIYGEPESVKRVEAFLLDQISISKKSGTLLVHKVLVFDKKIVRILTPGQKNYVEEIEKNYIVLAKGPAGTGKSFLAIAVGLNMLKNNLVQKMILTRPVVEAGEKLGFLPGDIQQKVDPYIRPLYDFLEELLGSEKLNKYIEKGMIEVAPLAYMRGRTFKYSFILLDEAQNTTPMQMKMFLTRFGEGSKMVVTGDVTQTDLDVGRTSGLTHAWEILRGIKGIGFVELTEKDVVRHDIVKEIIKAYERWEINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0G3</accession>
    <name>B8E0G3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583689.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353222.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1334"/>
    <dbReference type="EnsemblBacteria" id="ACK42608">
        <property type="protein sequence ID" value="ACK42608"/>
        <property type="gene ID" value="Dtur_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1334"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1379"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067083_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0G3"/>
    <dbReference type="OMA" id="DKIIMDP"/>
    <dbReference type="OrthoDB" id="1729109at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002825">
        <property type="entry name" value="Pept_S49_ser-pept_pro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01972">
        <property type="entry name" value="SDH_sah"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="280" mass="31389" checksum="46398D1B7D370CAD" modified="2009-03-03" version="1">MNFWDIFWIIFILSSISPIVRQRVIEAERFRLIQTLERKRGSRVITLIHRQETMNLFGIPIARYINIEDSEEILRAIRLTPEDMPIDLILHTPGGLVLAAEQIAHALKNHKGKVTVFVPHYAMSGGTFIALAADEIIMDENAVLGPVDPQLGEYPAASILNAINRKGADKVEDKTLILGDVAEKAIRQVKESVFELLKDKMPEEKAKEIAEILSTGTWTHDYPITVEEAQKLGLPVKVGLPKEIYALMNLYPQSPGSRPSVQYIPVPYQPYKGGANNKKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0K2</accession>
    <name>RL1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplA</name>
        <name type="ordered locus">Dtur_1373</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583727.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353261.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0K2"/>
    <dbReference type="SMR" id="B8E0K2"/>
    <dbReference type="STRING" id="515635.Dtur_1373"/>
    <dbReference type="EnsemblBacteria" id="ACK42647">
        <property type="protein sequence ID" value="ACK42647"/>
        <property type="gene ID" value="Dtur_1373"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1373"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1418"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0K2"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000141395" description="50S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <sequence length="242" mass="26429" checksum="90E7981803529222" modified="2009-03-03" version="1">MAKRGKRYQQLLSLIEKGRLYSPKEAVSLVKKLATAKFDETINLAVRLGVDPRHADQQVRGTVVLPYGTGKEKKVLVFAEGEKAQEAREAGADYVGGEDLVKQIESGWLDFDVAIATPDIMGTLKIPSRLGKILGPRGLMPNPKTGTVTNDIAKAVKEYKAGRVEFRTDRYGIVHVPIGKASFSEEALYKNLMTVLGTLLRLKPAAAKGQYFKSIYISPSMGPSVPIDTKNIADLVKQEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0L5</accession>
    <name>B8E0L5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584110.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353649.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1763"/>
    <dbReference type="EnsemblBacteria" id="ACK43035">
        <property type="protein sequence ID" value="ACK43035"/>
        <property type="gene ID" value="Dtur_1763"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1763"/>
    <dbReference type="eggNOG" id="COG2211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025379_2_0_0"/>
    <dbReference type="InParanoid" id="B8E0L5"/>
    <dbReference type="OMA" id="RAWMGSI"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="15"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK43035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="453" mass="51811" checksum="5C373577DE143ABF" modified="2009-03-03" version="1">MRVRNLFDISFVEDKELRKSLSLVILGVCFGIIFFNVTQGAPIAGFAKELGFGDLLYGVMLAMPVLGGAIQLFASYVLEKTRKRKLLFFLGGFIQRLPWLLVVILPFFVHDKNVLFSSIVFLLSITAIGSAFINVSFMSWMGDLVPIEIRGRFFSHRSMLATFVSLISGLLIGAFLDRFSDLYGFAVVFIFAVILGIFDILCFIWVYDPPMRGNDFSNVNFAKLFKESITHPKFSHFLLFAVLWNFALNISAPYFNLYMIKYLKMSYFDIALYVQIISNVTTILSVRILGRLIDRFGNKPVLQISTFIVSFLPYIWCFTTPNNWLLFVILVQIFAGVFWPGIDLSFNNLALGLSPNENRSFYIAVLNLFVGIINAISFILGGYIIEYVAPSIVNFINSLLHIHLVEYHLIFILSGMLRFTFLRIFIPKISEERSKPVEELTNHIVRRIRKRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0L7</accession>
    <name>B8E0L7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt ABC transporter, inner membrane subunit CbiQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1765</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584112.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353651.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1765"/>
    <dbReference type="EnsemblBacteria" id="ACK43037">
        <property type="protein sequence ID" value="ACK43037"/>
        <property type="gene ID" value="Dtur_1765"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1765"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0L7"/>
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        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
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        <property type="term" value="C:integral component of plasma membrane"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
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        <property type="entry name" value="ECF_CbiQ"/>
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        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
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    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="40"/>
            <end position="73"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="267" mass="31549" checksum="59881426AF4BE32C" modified="2009-03-03" version="1">MNNFIDKTLYEINRIVKDFLFFEVVETPDFWKDVKDDIKIVILILSLIGVSFIHNLCFLLLAYFLLLIFAYLLKIDLRKFMKRSFSFVLFFTVLIVIPYLFFNPETLNIGYSHKGLYVALRLIFRVLISISLANILFFTTPWINIVKGLRMLGVPSLAIAIIYMTYRYIFFFANLAQDIFLAKKSRTIEFNYKREYSFIGSAIGLLFMKARMLSEEVSQGMISRGFGKEFHPIIKREKYTIKDFLPIIMEILIIGVLIWMDRKFYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0M8</accession>
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        <submittedName>
            <fullName evidence="3">Transcriptional regulator, RpiR family</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">Dtur_1776</name>
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
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        <lineage>
            <taxon>Bacteria</taxon>
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        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43048.1"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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    <dbReference type="RefSeq" id="YP_002353662.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1776"/>
    <dbReference type="EnsemblBacteria" id="ACK43048">
        <property type="protein sequence ID" value="ACK43048"/>
        <property type="gene ID" value="Dtur_1776"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05013">
        <property type="entry name" value="SIS_RpiR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000281">
        <property type="entry name" value="HTH_RpiR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035472">
        <property type="entry name" value="RpiR-like_SIS"/>
    </dbReference>
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        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01418">
        <property type="entry name" value="HTH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
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    </dbReference>
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        <property type="entry name" value="SSF53697"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH rpiR-type" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="123"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK43048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="281" mass="31239" checksum="0F154FCF15EB6045" modified="2009-03-03" version="1">MDNSILEKIKEQKESFRDSEEKVANYILARWQEVLHLPITELAERIGVSEATIVRMCKKLGLRGFQELKIALATEKIQPIKTVHQAVQEGDDLETILKKVFSANIRAMESTLNVISVKEIERAIDAILNARQLQIYGVGGSGPVALDAQHKFMKTGIPTVAYIDSHMMAMSASILEPQDVVIGISASGSSKDIFEALELAKNRGATTIGITHYAKTPLDRVLDIKLSVSSEETFYRTESTSARIAQLSIIDTLYIGVALKRLDKMIENLKLTREAIVPKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0P3</accession>
    <name>B8E0P3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1791</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584137.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353677.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1791"/>
    <dbReference type="EnsemblBacteria" id="ACK43063">
        <property type="protein sequence ID" value="ACK43063"/>
        <property type="gene ID" value="Dtur_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1791"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1843"/>
    <dbReference type="eggNOG" id="COG0738">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048252_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0P3"/>
    <dbReference type="OMA" id="FFAMGNG"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="230"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK43063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="420" mass="46436" checksum="B1BFC1545767B79E" modified="2009-03-03" version="1">MSLKEKDYRWNFIVNSIDNAFFNLGMTFGSIQTLLPLFAKHLGAGNLEIGLIPAIANLGWAIPAIIGAKYSEKYKIKLHLVLKVTMGERLPYLFMALIAFFVAPNNSTLALYLSLLMLGIATFSMGFLGPPWMSMIGKVIEPSKRGVFFAMGNGLGAIMGVGGAGIARIILSKYPFPHNFGYSFLCASIALLISLAFLALTREYPDDQENPDIPLVEYIKSIKTVFKYKNFKNYVIARILNAFSVPFISFVVVFASKTFSIPDKVAADFTAILLISQAISSFLLGPLGDKYGHKLPLLIGRILIFLDILILLFAKNISYLYIAFILVGFINSAFWVGDSAMVLEISPPQHKELYIGALSLILSPFSFVAPLIAGKIADVKGFRFLFMTCLLISIINIVFFIYGVKDPRKNAENINNINNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0P4</accession>
    <name>B8E0P4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Auxin Efflux Carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584138.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353678.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1792"/>
    <dbReference type="EnsemblBacteria" id="ACK43064">
        <property type="protein sequence ID" value="ACK43064"/>
        <property type="gene ID" value="Dtur_1792"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1792"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_5_2_0"/>
    <dbReference type="InParanoid" id="B8E0P4"/>
    <dbReference type="OMA" id="TTFFWTL"/>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK43064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="302" mass="33773" checksum="E846682E87F9DC90" modified="2009-03-03" version="1">MLKILITLIIISLLGYLGKNYLFKEEDKEVISKFVYNFSLPALVFYSIYTNPPQISSFKVAITEWIISFIVGTLSIFLGFILKLSRETIGSLFLVSIGGNVTFMGYPIMEKLFGNQGLTLAILYDQLGMIVFVYTIGILVISLLVKPEKTTNRRFLGIERILINPPLWALIAGFLFQKINIPDFILESFSILGRATTPLMMFLLGLSLSKPYKDNKSIMGVSVGVLLKLILFPLFALITAKLLNLSDIPLKVTVLESAMPSMLTALVLSLQFNLDYVFTSQVITYSTLLSLITLNLWIGVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0T6</accession>
    <name>B8E0T6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Septum site-determining protein MinD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell division inhibitor MinD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1399</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase required for the correct placement of the division site. Cell division inhibitors MinC and MinD act in concert to form an inhibitor capable of blocking formation of the polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParA family. MinD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583751.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353287.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1399"/>
    <dbReference type="EnsemblBacteria" id="ACK42673">
        <property type="protein sequence ID" value="ACK42673"/>
        <property type="gene ID" value="Dtur_1399"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1399"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1446"/>
    <dbReference type="eggNOG" id="COG2894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0T6"/>
    <dbReference type="OMA" id="CESAKAY"/>
    <dbReference type="OrthoDB" id="1631847at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051782">
        <property type="term" value="P:negative regulation of cell division"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010223">
        <property type="entry name" value="MinD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01968">
        <property type="entry name" value="minD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="7">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="264" mass="28917" checksum="707B24FFA4A21322" modified="2009-03-03" version="1">MGKAIVITSGKGGVGKTTAVANIGTGLAMRGFKTVLVDTDIGLRNLDLLLGLENRIVYNLVDVVEGKCNLKQALVRDKRLNNLYLLPAAQTKEKESVTIEQMRALINDLKKDFDFVLIDSPAGIEHGFRSAISGADEAIVITTPEVSSVRDADRVIGLLEANGFENLSLIVNRVRFDMVKNGDMLGVDDLLEILSIELLGIVPEDENLIISVNKGEPIIYNSDKCKAGLAFSLIVKRLLGEDVSWDELEKGESFLERIFKFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0U8</accession>
    <name>B8E0U8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="5" type="ordered locus">Dtur_1411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583763.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353299.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1411"/>
    <dbReference type="EnsemblBacteria" id="ACK42685">
        <property type="protein sequence ID" value="ACK42685"/>
        <property type="gene ID" value="Dtur_1411"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1411"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1458"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_0_3_0"/>
    <dbReference type="InParanoid" id="B8E0U8"/>
    <dbReference type="OMA" id="HGGYGVI"/>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043024">
        <property type="term" value="F:ribosomal small subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="4">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="179" mass="20979" checksum="E90C3D4C33A1DF1F" modified="2009-03-03" version="1">MQINYVSKNVNITENLQEYAEKKLSKLSRFFDNIENIEVVFSEEDWRDGSKRHRVEVTLKANGKIIKASEANQDFRSSVDLVVDKLEAQLKKLKEKLVDKGRRTESIRGILIEETKEEKPEVVKVKRFLLKPMDLEEAILQMELLGHDFFIFRDAETDKIEVVYKRKDGKYGLIVSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0V2</accession>
    <name>B8E0V2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S-adenosylmethionine decarboxylase proenzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583767.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353303.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1415"/>
    <dbReference type="EnsemblBacteria" id="ACK42689">
        <property type="protein sequence ID" value="ACK42689"/>
        <property type="gene ID" value="Dtur_1415"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1415"/>
    <dbReference type="eggNOG" id="COG1586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_2_0"/>
    <dbReference type="InParanoid" id="B8E0V2"/>
    <dbReference type="OMA" id="FGPHLMV"/>
    <dbReference type="OrthoDB" id="1613081at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="133" mass="15282" checksum="9BBDEA4BCBED9380" modified="2009-03-03" version="1">MLGPHLVLDLYGCPKEKLEDVKFIYDLLDELPEQIGMQKIMPPYVMRYVPEDDPLDWGISGVVLIAESHIAIHTWPDLNYASVDIFSCKTFNIDLAKELIEKKLSAQKTEWEILVRGREFPINLLKRGRNAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Z2</accession>
    <name>B8E0Z2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353343.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1455"/>
    <dbReference type="EnsemblBacteria" id="ACK42729">
        <property type="protein sequence ID" value="ACK42729"/>
        <property type="gene ID" value="Dtur_1455"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1455"/>
    <dbReference type="eggNOG" id="ENOG503305D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2232286_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="105" mass="12255" checksum="727F3DFB3144D007" modified="2009-03-03" version="1">MNTQIGVWIFIPIIMGIALIPIPSSFLTKFLIVFLTLSYSIIFGSVRYAFFMHTLLNFSYIFSAPLYFIFGLFIDFSYVVGTYSFYVGIIAKKLQKTEEAWKWIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Z9</accession>
    <name>B8E0Z9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1462</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583814.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353350.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1462"/>
    <dbReference type="EnsemblBacteria" id="ACK42736">
        <property type="protein sequence ID" value="ACK42736"/>
        <property type="gene ID" value="Dtur_1462"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1462"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1511"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0Z9"/>
    <dbReference type="OMA" id="HITLRFL"/>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="108"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="53"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="194" mass="22531" checksum="7CFF665880F5DB0B" modified="2009-03-03" version="1">MAKRSSDKNTNYKRLFIAIEFEDSVKEHIYKFQKELKASIIGDIKWVEKENFHLTIRFLGETPESLIEDVKSILEEVSNYVDPFYISLEGFGAFPSLKSPRVLWIGIEEGLEELEKIFDFIEKRLVKKGLKKEDKPFSPHLTLGRVKDKDIKILKESSFSKQVVFVNSITLFESRLTSQGPIYTPIYKVSFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>B8E129</accession>
    <name>B8E129_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="9" type="ordered locus">Dtur_1492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
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        <property type="protein sequence ID" value="ACK42766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
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        <property type="gene ID" value="Dtur_1492"/>
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    <dbReference type="KEGG" id="dtu:Dtur_1492"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1541"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
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    <dbReference type="HOGENOM" id="CLU_041220_0_0_0"/>
    <dbReference type="InParanoid" id="B8E129"/>
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        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="KsgA/Erm"/>
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        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
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        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
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        <property type="entry name" value="rRNA_adenine_dimethylase"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
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    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
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        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RRNA_A_DIMETH"/>
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    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="34"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="29"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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    <feature type="binding site" evidence="6 7">
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        <location>
            <position position="75"/>
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        <ligand>
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        <location>
            <position position="100"/>
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        <ligand>
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        <location>
            <position position="119"/>
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        <ligand>
            <name>S-adenosyl-L-methionine</name>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="279" mass="32281" checksum="88AD316AE9BD9641" modified="2009-03-03" version="1">MDLTSKSKLIEILRRNNIFLKKSLGQNFLIDKNILKKIIDALEISKEDNILEVGCGVGTLTLELAKKAKKVIGVEIDKRFKSILEELLKDYNNVEILFEDVLKLDLSRIINLPYKLVGNLPYYISGSFLGEYFQKGPYAHLMVIMLQKEMAERLTSSPGSKKYSPLSILLHITYSYEIISKVSPSCFFPAPEVESVVLKLKFNPKLDKIYNKEFFFKLIKESFNQRRKFLLNNLERAFPSIDWKYVFTELNIDGKIRAEELSPEGYITLSNKAFNLWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E145</accession>
    <name>B8E145_DICTD</name>
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            <fullName evidence="1">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="1">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_0892</name>
    </gene>
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        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR006408">
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    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
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    </dbReference>
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        <property type="entry name" value="HATPASE"/>
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    <dbReference type="SFLD" id="SFLDF00027">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="263"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="760"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
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            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="839"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="870" mass="97998" checksum="E2FE38234BF71629" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>B8E182</accession>
    <name>B8E182_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mtnA</name>
        <name evidence="3" type="ordered locus">Dtur_0929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583294.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352824.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0929"/>
    <dbReference type="EnsemblBacteria" id="ACK42210">
        <property type="protein sequence ID" value="ACK42210"/>
        <property type="gene ID" value="Dtur_0929"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0929"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.966"/>
    <dbReference type="eggNOG" id="COG0182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_0"/>
    <dbReference type="InParanoid" id="B8E182"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="OrthoDB" id="1290468at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="344" mass="38145" checksum="397F03334367E15F" modified="2009-03-03" version="1">MNPIEWKNNILYILDQTKLPWKEDYILCFKYQQVIDAIKKMKIRGAPAIGVAAAYGITLAAIKYTGSNLADYVHEVIGEFAVSRPTAVNLFFAIERMAKVVNSNKNLSPSELKILLLEEAKKIENEEREKSIAISNFGAEILPDGVKVLTHCNTGSLATIGPGTALGIIKEGWKRGKISHVYFTETRPLLQGARLTGWELAKENIPATMITDNMVGYVFSKKIVDLVIVGADRITLRGDVANKIGTYSFAILAKYHNIPFYVAAPISTFDFNLEAGSEIPIEEREQEEVLSFVNKRITPEGISALNPAFDVTPAELISGIVTDKGVIYPPFKENIQKLKEELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1B9</accession>
    <name>B8E1B9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Malate dehydrogenase (Oxaloacetate-decarboxylating)</fullName>
            <ecNumber evidence="6">1.1.1.38</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.38" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583331.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352861.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0967"/>
    <dbReference type="EnsemblBacteria" id="ACK42247">
        <property type="protein sequence ID" value="ACK42247"/>
        <property type="gene ID" value="Dtur_0967"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0967"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1004"/>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1B9"/>
    <dbReference type="OMA" id="HKYAAVV"/>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="5">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="4">
        <location>
            <begin position="160"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="407" mass="44645" checksum="F6609CD3D29E544E" modified="2009-03-03" version="1">MNIYQESIELHRKHKGKIKIDSKIALKNKYDLSLAYTPGVAGVSEEIYKNNDEVYNLTIKANTVAVISDGSAVLGLGNIGPLSAIPVMEGKALLFKRFANIDAFPICLNTQDPEKIIEITYMIAPIFGGINLEDIAAPKCFIIEERLKKILDIPVFHDDQHGTAIVVYAALINALKLVNKKIHEVKIVILGAGAAGIAITKLLLREGAKNIRILDRNGIIYPGRKENMNEIKEEIARTINPEGEKGELKDALKGADVFIGVSQANLFPPEYIRLMNKDPIIFAMANPIPEIMPEEAKKEGVKIIGTGRSDYPNQINNLLAFPGVFRGAFTVRAKEINDEMKVAAAKAIASLVEEPQEDYLIPSPLDERVVPAVSFSVAKAAIETKVAKIFKDDNKIIEDIKQALGGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1C1</accession>
    <name>SYH_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="1">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisS</name>
        <name type="ordered locus">Dtur_0969</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583333.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352863.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1C1"/>
    <dbReference type="SMR" id="B8E1C1"/>
    <dbReference type="STRING" id="515635.Dtur_0969"/>
    <dbReference type="EnsemblBacteria" id="ACK42249">
        <property type="protein sequence ID" value="ACK42249"/>
        <property type="gene ID" value="Dtur_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0969"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1006"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_0"/>
    <dbReference type="InParanoid" id="B8E1C1"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000199128" description="Histidine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <sequence length="411" mass="47985" checksum="77EDAD1E7E60467B" modified="2009-03-03" version="1">MSIGLPRGVQDILPDEIPFWHLIENIARSLFEKYNYEEIRTPIFEFTELFVKGTGETTDIVMKEMYTFQDKKGRSLTLRPEGTPGVIRAYLMNKIYTTKPIWKVYYIGPMFRYERPQSGRYRQFHQLGVEVLGRKDPYIDFEVISLAVEILKSLKLENLEIEINSLGCLKCRPAYREALKNYFYQYKDLLSPIDQERLERNPLRILDSKDEKIIPLKENAPQPLDFLCNDCKDHFDKVLRYLQEASLNFKISPKLVRGLDYYTRTVFEITTTSLGAQNAVVGGGRYDNLVETYGGPSTPGLGFALGMERLILLIKQQDKIKIEKPSLFFLAIENEKYIKKAVEISKILRINHRVEIGSPNEPLRTQLKWADKLNSDYVIFINQMIEKDILRIKNFKTGEEKEIRIENLKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1D8</accession>
    <name>B8E1D8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="12" type="ordered locus">Dtur_0986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583350.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352880.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0986"/>
    <dbReference type="EnsemblBacteria" id="ACK42266">
        <property type="protein sequence ID" value="ACK42266"/>
        <property type="gene ID" value="Dtur_0986"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0986"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1023"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_3_0"/>
    <dbReference type="InParanoid" id="B8E1D8"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="114" mass="13297" checksum="E1132D15322E4C76" modified="2009-03-03" version="1">MIEVKAESKYLRVSPYKARRVIDLVRGKMVEEAEAILENLPHKSARLILKCLRSAKANAEHNYGLRADRLYISKAFVNEGPRWKRLNPRARGRADIIQIRNSHIVIYVKEKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1H4</accession>
    <name>B8E1H4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative hypoxanthine phosphoribosyl transferase with additional GAF motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582584.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352113.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0168"/>
    <dbReference type="EnsemblBacteria" id="ACK41499">
        <property type="protein sequence ID" value="ACK41499"/>
        <property type="gene ID" value="Dtur_0168"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0168"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.174"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873657_0_0_0"/>
    <dbReference type="OMA" id="RTFPLEW"/>
    <dbReference type="OrthoDB" id="1143054at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="310" mass="37174" checksum="04C4092F931C5B6F" modified="2009-03-03" version="1">MSKIKLITVSRDFGIDIDHIIERISSKVNGEIIDKQKILNYLKEININVEEFIKKEKELIYGKKDKEFIEDYKKYIKEGVKLIIEEKDSILFLLGRGGQFIFRDEDYAFHLNIFAPLNFRIKYLTQKYLLPEEKALEIIKEKDFEREAFYSIMFGTDWKNPYLYNLVIDRSVFTPEEIEDMILKIIEKKEISKIQLEQIPLPTKPNFANKSEEEFAKILSFYQIRWEYEPRTFPLEWDSEGNIVESFTPDFYLPDFDLYIELTLQKPRVMSEKLKKIKKLKELYPNIKIKLFYGKEYEKLLAKFGVMGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1K7</accession>
    <name>B8E1K7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sugar fermentation stimulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582617.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352146.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0203"/>
    <dbReference type="EnsemblBacteria" id="ACK41532">
        <property type="protein sequence ID" value="ACK41532"/>
        <property type="gene ID" value="Dtur_0203"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0203"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.211"/>
    <dbReference type="eggNOG" id="COG1489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052299_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1K7"/>
    <dbReference type="OMA" id="VTAHCPN"/>
    <dbReference type="OrthoDB" id="1375946at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SfsA_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="SfsA" evidence="1">
        <location>
            <begin position="80"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="218" mass="25836" checksum="8C5D34580833A8B3" modified="2009-03-03" version="1">MIFERLEKAKVIKREKRFRLYVDYQGKELLTYLPNSGRLQDIVYPSATVYVKRREDKKRKTLYEAVLGVQNGVLVSLNASLANKIFEENLFRFPVKVKELKREFNYHGKRYDFLINSKILVEVKSVTLVKNGVGMFPDAPTKRGSEHLEFMKDWIFEKWVIFVIQREDVRLFKPNKDLDERFYQATQVLKRSGGVFFAFTCYVSEFGIDFKEFVDVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1L6</accession>
    <name>B8E1L6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="7">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Dtur_0212</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7 10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7 10">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582626.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352155.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0212"/>
    <dbReference type="EnsemblBacteria" id="ACK41541">
        <property type="protein sequence ID" value="ACK41541"/>
        <property type="gene ID" value="Dtur_0212"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0212"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.221"/>
    <dbReference type="eggNOG" id="COG0538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023296_1_1_0"/>
    <dbReference type="InParanoid" id="B8E1L6"/>
    <dbReference type="OMA" id="HGTVQRH"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP metabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0521">NADP</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="12">
        <location>
            <begin position="9"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="94"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="304"/>
            <end position="309"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="8">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ACK41541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="401" mass="46160" checksum="218611D6957DE1C5" modified="2009-03-03" version="1">MGKIKVKNPIVELDGDEMARVMWKWIKEELIFPYLDIPIKYFDLGIQNRDATSDMVTLEAAKAIKEYKVGVKCATITPDQERVKEYNLKKAWKSPNATIRAYLDGTVFRKPIIVKNIPPYVKTWKKPVIIGRHAYGDIYNAFEYRVEEPAEIEVIVKNSEVKEFKVHTFDGKGIFMVLHNTEKSIRSFAKSCINYALSEKVDLWFSAKDTISKIYHGYFKEIFQEEVERRKEDFEKAGINYRYFLIDDAVAQILKSEGGMLWACMNYEGDVMSDMIAAGFGSLGLMTSVLVSPEGEYEFEAAHGTVRRHYYEYLKGNKTSTNPTASIFAWTGGIRKRGELDGTPEVVNFANKLEEATIKTIESGIMTKDLQPQAYPPVDRYYYTEDFIKAVKERLEFLLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1L9</accession>
    <name>B8E1L9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582629.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352158.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0215"/>
    <dbReference type="EnsemblBacteria" id="ACK41544">
        <property type="protein sequence ID" value="ACK41544"/>
        <property type="gene ID" value="Dtur_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0215"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_0"/>
    <dbReference type="InParanoid" id="B8E1L9"/>
    <dbReference type="OMA" id="FIITARV"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="113"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="343" mass="38303" checksum="EC10DE8ED661C673" modified="2009-03-03" version="1">MPKTAMKPFLKYIGRRLFFLILTYFVAITIIFILPRAIPGNPLAVILQRIAVQGASNPETMSNVQKTMMEEFGFNKPIHIQYLNFLGRLFKGDLGTSIHYYPKKCIDVLAPFIPWTLFLLIPATLTAWIIGNTLGAIAGNKRGTWIDNIVLNSSLVISQIPYYWLGMLLIYTLAVKLKIFPNQGGYSQGLIPNLSLTFILDVLYHYILPFLSIVIAAIGGWAIGTRLLVIYELDADYTVFAVNLGMRDNTVFKYVFRNILLPQITGLALNLGSALGGALITELIFNYPGTGYILFRALSTLDYTLIQAIFVILIVAIYLANFIVDFVYAIVDPRIRLGQGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1P7</accession>
    <name>B8E1P7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0246</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352186.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0246"/>
    <dbReference type="EnsemblBacteria" id="ACK41572">
        <property type="protein sequence ID" value="ACK41572"/>
        <property type="gene ID" value="Dtur_0246"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0246"/>
    <dbReference type="eggNOG" id="ENOG502ZEYY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1608242_0_0_0"/>
    <dbReference type="OMA" id="GYNGFYY"/>
    <dbReference type="OrthoDB" id="2043847at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="179" mass="20953" checksum="7530DD36590F0FE2" modified="2009-03-03" version="1">MTLIYIMRRVIKVKKVSIGLFIILIILLVIVFASSFRNRDYGQDDFPYKGALFLHDGDYVIFECTEGYNGFYYMTGKDYEVPVQVFDYNTGKEIGGYLFLPGNPYPVGENFSYAPFRWMDLQQGYKGRTLKIVLRENRKIYNKTYGDRDLLIKFKPGTTVLYWHGVDSTDWCDLDYVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1R6</accession>
    <name>B8E1R6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352313.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0395"/>
    <dbReference type="EnsemblBacteria" id="ACK41699">
        <property type="protein sequence ID" value="ACK41699"/>
        <property type="gene ID" value="Dtur_0395"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0395"/>
    <dbReference type="HOGENOM" id="CLU_975679_0_0_0"/>
    <dbReference type="OrthoDB" id="714423at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="SSF48537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="285" mass="33937" checksum="AB08D8BDAEC2E1A7" modified="2009-03-03" version="1">MHFLDFPSLMNNLSHDSHGNRRSGIHNNIDGYNYIRHIKFVKGEKDDDYWVDWWMGNDDFCMVHSGVLLDMYERDEGGRDKNGNLISSVNYSCYTRWDKDHHNIIYAPIDNLSGYWFKQNQDWWSHPYWGPYYLGYALHAVGDASEMHHVFNTLGWGHSEFESWASYWYQFRGEKEYMSRSRWFDMRKVRDALNTVFAQDGIPPYRRDVKWLIERLAREVYNYSIRNWSTLWGREPSKTTFYKPFELYDGNLSKSCSMRCCYYGKSLLSTCCFSNSNSSSCNGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1S2</accession>
    <name>B8E1S2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNP-1 like RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582790.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352319.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0401"/>
    <dbReference type="EnsemblBacteria" id="ACK41705">
        <property type="protein sequence ID" value="ACK41705"/>
        <property type="gene ID" value="Dtur_0401"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0401"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_8_0"/>
    <dbReference type="InParanoid" id="B8E1S2"/>
    <dbReference type="OMA" id="LPWNTTA"/>
    <dbReference type="OrthoDB" id="2029304at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="92" mass="10554" checksum="F5C09AB4DE0CAD97" modified="2009-03-03" version="1">MSKTLYVGNLPWSTTEEELKNIFASHGTVYSARIISDRNTGRSKGFGFVEVDEKEAEKMISALNNTEVKGRRIIVNEAKPREERPRERRNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1V6</accession>
    <name>B8E1V6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Extracellular solute-binding protein family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582824.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352353.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0437"/>
    <dbReference type="EnsemblBacteria" id="ACK41739">
        <property type="protein sequence ID" value="ACK41739"/>
        <property type="gene ID" value="Dtur_0437"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0437"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.462"/>
    <dbReference type="eggNOG" id="COG1653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031285_5_0_0"/>
    <dbReference type="InParanoid" id="B8E1V6"/>
    <dbReference type="OMA" id="IMGYDRG"/>
    <dbReference type="OrthoDB" id="447734at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="424" mass="48364" checksum="3FBFA71A08641BE3" modified="2009-03-03" version="1">MKKYFKLTILVLVLVSFILAISPAQQQITLRIIWWGSQDRHNRTLKVIELFQKKYPNIKIVSEYTGWSEYYTKLTTMAAGGNLPDIMQQDHAYIRGWVEKGLLLPLDDLVAQGIINLKDVAKSIVDSGRLSGKLYAINLGNNSQAFAIDPEVFRKAGVPLPPTLWTWDDFKRIARIIHRKLGIYGAAENLGDHNIFRVWTIENGGYLFSEDGKSLGYEDDNVYASFYKMLLELQDEGVIPSRDVEVARGSVSPEQRFICLGKSAMQFTWSNQLTAMSKALKDKPLKLYMIPTLNGKVGNFLKPSMFFAINAKTKYPKEAAMFINFFINDIEAGKILMAERGVPVSKKVQLALKPILTPVEKEIFNFIATVEKYGAPTPAPDPERWQEIYNNVYTPLYDQIMYKKITPEEAAKRFREQVTQILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1W5</accession>
    <name>B8E1W5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase GroES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582833.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352362.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0446"/>
    <dbReference type="EnsemblBacteria" id="ACK41748">
        <property type="protein sequence ID" value="ACK41748"/>
        <property type="gene ID" value="Dtur_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0446"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.471"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_0"/>
    <dbReference type="InParanoid" id="B8E1W5"/>
    <dbReference type="OMA" id="QFGVADY"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="12"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="365" mass="39979" checksum="79F9755AD2D40624" modified="2009-03-03" version="1">MIMKAKIAVLEGFKKPLVIKHFDIPPLPQGSILVKMVASGICGSDLHMVDGEDPRVPLPIILGHEGVGEIVEINGEKKDLNGDTLKKGDLIIWDRGVVCGECYFCKVLKTPYLCENRKIYGINRSFKDYPYLTGAYAEYIILEKKTEILKLSSKTDPTVLVMAGCSGATAVHAIDSLEDNLLDKTVVVQGGGPLGIFALALSKFQGAKNTILITGSSFRKEIAEKIGVDVVLDRTILKEEERINKILDMTYGKGADVVIEATGTNKAIPEGLRILRKGGTYIVVGVASPQEKVPVDFYDVSSKNITIKGVWVSDAEHFKKAVSFLEKNQDLFAPVVTHKISLDEINHGLDLVRERKAGKVVIEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1X1</accession>
    <name>B8E1X1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582839.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352368.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0453"/>
    <dbReference type="EnsemblBacteria" id="ACK41754">
        <property type="protein sequence ID" value="ACK41754"/>
        <property type="gene ID" value="Dtur_0453"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0453"/>
    <dbReference type="HOGENOM" id="CLU_205139_0_0_0"/>
    <dbReference type="OMA" id="VGSIMAF"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="67" mass="7805" checksum="493EA5C710E9145A" modified="2009-03-03" version="1">MEKIAYIILSIIVIVWLLLIIVGSIMAFPVGMISLLLILAFGLLFIKVLKERIKSKREEEKYKDIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1X2</accession>
    <name>B8E1X2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Auxin Efflux Carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_0454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the auxin efflux carrier (TC 2.A.69) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582840.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352369.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0454"/>
    <dbReference type="EnsemblBacteria" id="ACK41755">
        <property type="protein sequence ID" value="ACK41755"/>
        <property type="gene ID" value="Dtur_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0454"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.479"/>
    <dbReference type="eggNOG" id="COG0679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056175_1_2_0"/>
    <dbReference type="InParanoid" id="B8E1X2"/>
    <dbReference type="OMA" id="PHMFRNS"/>
    <dbReference type="OrthoDB" id="2033473at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK41755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="315" mass="35674" checksum="0642226A18310246" modified="2009-03-03" version="1">MRVFFSALQGVLEIVIIIAIGYILTHKKWFEGKTADLFAKIVLNLSLPLSMIVNISSFFTKNDLISSAKGLIIPFLSILISYFLGYLLAIIFKTRKGRRGLLAGIFSLSNSIFIGLPMSQALFGDIATPYTLLYYMANTTIWWSFGVYGIILDTQEKREKILSLVLLKRIFNPPFIGFLIGVVIVLIDFKPPKFLFDSFKLIGNLTTPLSLFYVGITMYHMGFEKFKLDKDAILTFLGRFLITPVLVIILEFFIPIPKLMRDVFIIMSAMPVMVNSSIVARMYGGDYEFAVSMITYTTLFSVVIMPLYMVLLSKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>B8E222</accession>
    <name>GLMM_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="1">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmM</name>
        <name type="ordered locus">Dtur_1019</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583382.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352913.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E222"/>
    <dbReference type="SMR" id="B8E222"/>
    <dbReference type="STRING" id="515635.Dtur_1019"/>
    <dbReference type="EnsemblBacteria" id="ACK42299">
        <property type="protein sequence ID" value="ACK42299"/>
        <property type="gene ID" value="Dtur_1019"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1019"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1056"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_0"/>
    <dbReference type="InParanoid" id="B8E222"/>
    <dbReference type="OMA" id="PHNPEPL"/>
    <dbReference type="OrthoDB" id="1265792at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000201088" description="Phosphoglucosamine mutase">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <sequence length="447" mass="49989" checksum="C1F815E092616CC7" modified="2009-03-03" version="1">MRRFFGTDGIRGVVNEDLTPELAYKLSRAIVGYFGNVKGKKVIIGSDTRNSKDMLKSALVAGFTSGGMNVLDVGVISTPALSYLVKNQDEVLLGVMISASHNPVEYNGIKIFKNDGFKLDDDVEAEIENYLLKEDNYYRANPREIGVIYDFSHIKEKYKNYLREIINGNFEGYKVMLDCAFGSLSEIAPEVFRELGAEVVAYNTKYNGLNINENCGAVYPETSKKLFLNSGAHIGFTYDGDGDRVIAFSENGEIIDGDIMLGILAKYLKEKGLLKGDKIVGTIMTNLGLEEYLKNINVELIRTKVGDRYVLDEILKYGLNLGGETSGHIILFDYMSTGDGLLTSLFLLKILKEKGVKLSELAKDIKIFPQVHEKVSVKGLNITEDMEKRFIEITEEVINGKNIRYIVRKSGTEPVVRITLEGDVPKEYLNELVLEIKSRIIDLLSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>B8E226</accession>
    <name>B8E226_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="9">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">alaS</name>
        <name evidence="12" type="ordered locus">Dtur_1023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="9"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583386.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352917.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1023"/>
    <dbReference type="EnsemblBacteria" id="ACK42303">
        <property type="protein sequence ID" value="ACK42303"/>
        <property type="gene ID" value="Dtur_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1023"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1060"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_0"/>
    <dbReference type="InParanoid" id="B8E226"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="11">
        <location>
            <begin position="1"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="722"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="865" mass="99397" checksum="45C27C9A14DFB71B" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>B8E233</accession>
    <name>B8E233_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583393.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352924.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1030"/>
    <dbReference type="EnsemblBacteria" id="ACK42310">
        <property type="protein sequence ID" value="ACK42310"/>
        <property type="gene ID" value="Dtur_1030"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1030"/>
    <dbReference type="eggNOG" id="COG4726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_693948_0_0_0"/>
    <dbReference type="OMA" id="NWYNSAT"/>
    <dbReference type="OrthoDB" id="2105966at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="397" mass="43538" checksum="1A03A66FD5C4FBC7" modified="2009-03-03" version="1">MLNKEKGQLIFAVLIVLFVFLLGMIIIQLMPSEYAITKRTVESNQAFYLAQSGLQQAIYFINNNPDLAFLELSLRKSGQSNLLSYTLTYTYGGNKKENINLNSISLGEYSVNVTYSLSNMSSGGIIVSFPIYKIVSIGYIPSIANPRVVRSIEIYGNNTDISLDPFKFAVYAGKSVSFSGKSAVIEGERLPDGSFDTAIYSNGPVDLRNPPLINGTYSPILGKDVIANDSTLTMPVLNDSYLKSISQSQGLYRSGNNIDIGNIVSYAKSNPNWYNSATKTWLTWSLVIYIEGSAKMAGNVEFQGMVIVKGDVKITGTGNKIRGILYAAEVDTAVQDLSIYGDPIIEGTSIGEDVSIGGNSTVRHNKQYIENIFKTHSITNIVKAVKTKLKILAWQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E242</accession>
    <name>B8E242_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Biotin carboxylase</fullName>
            <ecNumber evidence="5">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="5"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583402.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352933.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1039"/>
    <dbReference type="EnsemblBacteria" id="ACK42319">
        <property type="protein sequence ID" value="ACK42319"/>
        <property type="gene ID" value="Dtur_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1039"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1076"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_0"/>
    <dbReference type="InParanoid" id="B8E242"/>
    <dbReference type="OMA" id="ITHFHTP"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="7">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="447" mass="49936" checksum="AF1C4C21C950247B" modified="2009-03-03" version="1">MFKKILIANRGEIAVRVIRACRELGIKTVAIYSEADKESLHVYMADEAICIGPPPASQSYLNIPNIISAALVTNAEAIHPGYGFLAESARFAEICQDHGIVFIGPKKEVIENLGDKARAKKLMKEAGVPLLPGSEGLIEDEKQALKVAKEIGFPVLIKATAGGGGKGMRVSYSPEELVKNIRLAKMEAEKNFGNPGVYIEKFIEEPRHVEIQILGDQYGNIISLGERDCTIQRRYQKLIEESPSPVVNNRIREAMSRAAIRGAYKVGYVGPGTFEFLLDKDGKFYFMEVNTRIQVEHTVTEMVTGIDLVKWQILIAAGEKLDLKDVTLRGHAIECRINAEDPDNNFSPSIGKIEKYIPPGGPFVRIDTHIYEGYEMVPFYDSLLAKVITWGKDREEAIIRMRRALNEFIVRGLKTTIPLHLKILENSSFIKGDYSTNFLARRILVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E243</accession>
    <name>B8E243_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asp23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583403.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352934.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1040"/>
    <dbReference type="EnsemblBacteria" id="ACK42320">
        <property type="protein sequence ID" value="ACK42320"/>
        <property type="gene ID" value="Dtur_1040"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1040"/>
    <dbReference type="eggNOG" id="COG1302">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113198_4_1_0"/>
    <dbReference type="InParanoid" id="B8E243"/>
    <dbReference type="OMA" id="DGVHAMG"/>
    <dbReference type="OrthoDB" id="2035639at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005531">
        <property type="entry name" value="Asp23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34297">
        <property type="entry name" value="PTHR34297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03780">
        <property type="entry name" value="Asp23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="122" mass="13391" checksum="9E84A98DD7692A98" modified="2009-03-03" version="1">MKEELSYGSVNISKEVIAIIAGIAAQEIEGVAQVGESIASFVKLVSGIPIGRGLKVELIDKDVYIKIPVYVKQNVFFPDVARDIQTHVKEVVESMTGLNVREVNVIIKGVILGKKREEEKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E256</accession>
    <name>B8E256_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_1053</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583416.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352947.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1053"/>
    <dbReference type="EnsemblBacteria" id="ACK42333">
        <property type="protein sequence ID" value="ACK42333"/>
        <property type="gene ID" value="Dtur_1053"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1053"/>
    <dbReference type="eggNOG" id="COG1126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="InParanoid" id="B8E256"/>
    <dbReference type="OMA" id="APIWVRR"/>
    <dbReference type="OrthoDB" id="1191583at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015424">
        <property type="term" value="F:ABC-type amino acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030679">
        <property type="entry name" value="ABC_ATPase_HisP-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039085">
        <property type="entry name" value="ABC_ATPase_HisP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK42333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="242" mass="27245" checksum="7D1CA3E992BA9910" modified="2009-03-03" version="1">MIKVVNLHKKFKHLHVLKGINLEVKKGEVLVIIGPSGGGKSTLLRCINRLEEPTEGEIYIDGIKITDSSVDINKVRQKVGMVFQLFYLFPHLTVLDNITLAPIKVKKMDPKIATEKAYELLKRVGLVDKAKSYPSQLSGGQQQRIAIARALAMEPEVMLFDEPTSSIDPEMTKEVLDVMRELAHEGMTMIIATHEMGFAKEVANRVIFLDQGRIVEEGTPKEIFEHPKEERTIEFLSKILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2B2</accession>
    <name>B8E2B2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator receiver and ANTAR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583472.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353003.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1110"/>
    <dbReference type="EnsemblBacteria" id="ACK42389">
        <property type="protein sequence ID" value="ACK42389"/>
        <property type="gene ID" value="Dtur_1110"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1110"/>
    <dbReference type="eggNOG" id="COG3707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_65_0_0"/>
    <dbReference type="InParanoid" id="B8E2B2"/>
    <dbReference type="OMA" id="QKTSMDR"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="125"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="197" mass="22550" checksum="BDD39A017A7D1763" modified="2009-03-03" version="1">MKTVRVLIAEDEPIVRMDLKELLESQGYEVIGEASDGKIAIELARKLKPDVIIMDIRMPNLDGIEAAKILTQEEIAPIIFLTAYSDRELVEKAKEVGVVAYIVKPFKESDLFPAIEIAIARFKEFQLLRKEVEDLKDALETRKLVDRAKGILMDREGLKEHEAFRLIQKASMDKRKPMKEIAQAIILAYELKDKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2D0</accession>
    <name>B8E2D0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="1">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Dtur_1128</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353021.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1128"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42407">
        <property type="protein sequence ID" value="ACK42407"/>
        <property type="gene ID" value="Dtur_1128"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1128"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1165"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_7_0"/>
    <dbReference type="InParanoid" id="B8E2D0"/>
    <dbReference type="OMA" id="YQLTSMM"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="11">
        <location>
            <begin position="71"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="10">
        <location>
            <begin position="339"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="625"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ACK42407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="648" mass="73083" checksum="CA37D48C66295577" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2F8</accession>
    <name>B8E2F8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Xanthine/uracil/vitamin C permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583878.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353416.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1528"/>
    <dbReference type="EnsemblBacteria" id="ACK42802">
        <property type="protein sequence ID" value="ACK42802"/>
        <property type="gene ID" value="Dtur_1528"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1528"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1577"/>
    <dbReference type="eggNOG" id="COG2252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_0"/>
    <dbReference type="InParanoid" id="B8E2F8"/>
    <dbReference type="OMA" id="YVDIIDC"/>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="440" mass="46448" checksum="96F52C92D191B8AE" modified="2009-03-03" version="1">MFGALAKYFGFREKGTSWSNEIIAGLTTFVTMAYILFVNPNILGDAGMPKSAVLMATAIGAGIATLTMGLYAKLPFALAPGMGLNAYFAYSVCHGFGLPWQVALGAVFIDGIIFLILSILPVRKWIIQSIPLNIKLATSVGIGLFIALIGLRSAGIVVKSDATLVTLGSLKTPETLLSIFGIIVIALLMALNVKGNILLGIIITTIVGAFVKGSNGEYITHFTGNIIALPNWGEFSKTFLSLDILGALKWGFFSIIFTFTFVDMFDTVGTISGLASKLNILKEDGSFEGAERALVSDAVGTIAGALCGTSTITTYIESAAGIAEGGKTGAVSLVTGLLFLLSIILWPLAGIIPSAATAPALVIVGFLMMEPILKINFKDIAEALPAFVTIIAMPFTYSVANGLILGILSYVLLKILTGKFKDLNPVLIILSILFILYFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2L2</accession>
    <name>B8E2L2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353470.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1583"/>
    <dbReference type="EnsemblBacteria" id="ACK42856">
        <property type="protein sequence ID" value="ACK42856"/>
        <property type="gene ID" value="Dtur_1583"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1583"/>
    <dbReference type="eggNOG" id="COG1618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103145_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2L2"/>
    <dbReference type="OMA" id="GAMEFKC"/>
    <dbReference type="OrthoDB" id="1935037at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00796">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004948">
        <property type="entry name" value="Nuc-triphosphatase_THEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43146">
        <property type="entry name" value="PTHR43146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03266">
        <property type="entry name" value="NTPase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="169" mass="20096" checksum="D075AB5751A2EDEE" modified="2009-03-03" version="1">MKIFITGQPGVGKTTLLKKIYNFCREKSIVVCGFITEEVRENRFRIGFDLITLGDNQRLNFASIYKETPYKFGKYFLDIAALENVMDRIFCIEAEVYIIDEIGKMEFFSERFKEKIHKIMENDKLNIVASLHRDFVKEFKKYGKVYYLTQDNRDLVFEEVKQEILILKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2M0</accession>
    <name>B8E2M0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NHL repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583939.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353478.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1591"/>
    <dbReference type="EnsemblBacteria" id="ACK42864">
        <property type="protein sequence ID" value="ACK42864"/>
        <property type="gene ID" value="Dtur_1591"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1591"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1641"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024978_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2M0"/>
    <dbReference type="OMA" id="NILWYKK"/>
    <dbReference type="OrthoDB" id="627025at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="643"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="6">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="8">
        <location>
            <begin position="491"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="686" mass="79708" checksum="7D8C52C37F8234C4" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2N7</accession>
    <name>B8E2N7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SpoIID/LytB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583956.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353495.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1608"/>
    <dbReference type="EnsemblBacteria" id="ACK42881">
        <property type="protein sequence ID" value="ACK42881"/>
        <property type="gene ID" value="Dtur_1608"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1608"/>
    <dbReference type="eggNOG" id="COG2385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021203_3_3_0"/>
    <dbReference type="InParanoid" id="B8E2N7"/>
    <dbReference type="OMA" id="LCQWGAK"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoIID" evidence="1">
        <location>
            <begin position="115"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="363" mass="41293" checksum="2F430AE99AECA1EA" modified="2009-03-03" version="1">MLRRLVIAFFLIFIFVFLNGSYSQNIPLVRIGITKIDSDAYFSNVGRMSTDFLDIKVEGKGYVKVRVKNGSGFIESNTGILSVTLPLRIYPDGYYVNYNSNYYRGYLEILPSGWLINVLNMEEYLLSVVPSEMPVSYPLEALKAQAIASRTYALVNRGKHGEFDLCNTTHCQVYKGMSVENERSTRAVMETLGEVITYNGQLIKAFFHSSSGGYTEDCKYVWGEDLPYLKSVRDVDELINDTWSRVISINELTNKLNSVGINLSDSFSIELEKTNSGRVYTVYFKSDQGIYSLKGTTFRSLFNLPSTLFDMELGSYYLFLSGRGNGHGVGLSQKGARFLAEKGYNYREILKYYYQGVEIVKWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2P8</accession>
    <name>B8E2P8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583967.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353506.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1619"/>
    <dbReference type="EnsemblBacteria" id="ACK42892">
        <property type="protein sequence ID" value="ACK42892"/>
        <property type="gene ID" value="Dtur_1619"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1619"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059362_3_1_0"/>
    <dbReference type="InParanoid" id="B8E2P8"/>
    <dbReference type="OMA" id="CAIAAYD"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020051">
        <property type="entry name" value="SagB-type_dehydrogenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03605">
        <property type="entry name" value="antibiot_sagB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="221" mass="25319" checksum="EAFAEB36B3CE2261" modified="2009-03-03" version="1">MEYVISFIIGVISLIKFTYAQNGKVIKLPTPSFKSSISIEEALLYRRSKRFYKDLPLTTQELSQILWASQGISDSDYKFRTCPSAGALYPLEVYISILKVEGIESGIYKYTPEKHEIIQLYKNHKRDELYEASLKQEWVKWAPVVLIICASFYKTKARYGERGIRYIYIETGHCAQNIYLQCVSLGLGTVAVGAFDDDEISKILNLPKFEIPTYLMPIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Q6</accession>
    <name>B8E2Q6_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 4">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583975.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353514.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1627"/>
    <dbReference type="EnsemblBacteria" id="ACK42900">
        <property type="protein sequence ID" value="ACK42900"/>
        <property type="gene ID" value="Dtur_1627"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1627"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1676"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_1_2_0"/>
    <dbReference type="InParanoid" id="B8E2Q6"/>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="OrthoDB" id="1402673at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="5">
        <location>
            <begin position="6"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="287" mass="32384" checksum="BEDF349EAEB0AF2F" modified="2009-03-03" version="1">MIKKAIFPAAGLGTRFLPATKAQPKEMLPVVDKPIIQYAVEEAVNSGIDEIIIVTGRNKRAIEDHFDISFELEYFLQKKGELDLLKQVREISELATVYYIRQKEPLGLGHAVLVTKELVKNEPFAVILSDDLIVSDVPCIKQMIEIYERYKCSVIAVEKVPREEVKNYGVIAGKEIDDGIYQVTDLVEKPLIEEAPSDLAIVGRYILTPGIFYMLEKVKPGRGGEIQLTDGLKLLLEKEAIYAYEFKGKRYDTGSKLGFLIASVELALKREGLGEQFREYLKSLRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2S0</accession>
    <name>B8E2S0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583502.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353034.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1141"/>
    <dbReference type="EnsemblBacteria" id="ACK42420">
        <property type="protein sequence ID" value="ACK42420"/>
        <property type="gene ID" value="Dtur_1141"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1141"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1178"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_1_0_0"/>
    <dbReference type="InParanoid" id="B8E2S0"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="185" mass="21482" checksum="A625F30EC262AE6C" modified="2009-03-03" version="1">MSSEIKVSGGFLKDKKVKVLRQGNYRITMEQVRRSMFNIISEKVLGSFFLDLFAGSGIVGIEAISYGAEKSVFVENHIHAVKLLRENLKNLGIQEKTKVIYKDVFEFLNKTPEEKYDIIFADPPYELSEKILNVVEYVNNYNWLKIDGILIIEHHKKTILPDDLFNLSKFLEKNYGETVLSFYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2S3</accession>
    <name>B8E2S3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583505.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353037.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1144"/>
    <dbReference type="EnsemblBacteria" id="ACK42423">
        <property type="protein sequence ID" value="ACK42423"/>
        <property type="gene ID" value="Dtur_1144"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1144"/>
    <dbReference type="eggNOG" id="COG1067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1347114_0_0_0"/>
    <dbReference type="OMA" id="AKNPHFY"/>
    <dbReference type="OrthoDB" id="2123104at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="204" mass="23552" checksum="103C872DF583C74C" modified="2009-03-03" version="1">MQIRIVIVIIGFFLILEILASFFVYFDEGKVVNVKELFLNIPEDFPSNFYILVLKAKNPHFYDFFYHLILGDLYSYSQVSKYKLVKFEGFNVKDEVQFYGRSEMLCLILAFWAYKKGLKFSDNLKIGVIGDVSKEGEVLSVAGASIKYSTALENDINILIAPIQNKKEIKNFDNKSLYCLFVRHVEDAKKNLLKFVSPKVVNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2T3</accession>
    <name>B8E2T3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583515.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353047.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1154"/>
    <dbReference type="EnsemblBacteria" id="ACK42433">
        <property type="protein sequence ID" value="ACK42433"/>
        <property type="gene ID" value="Dtur_1154"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1154"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1191"/>
    <dbReference type="eggNOG" id="COG4603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040769_0_2_0"/>
    <dbReference type="InParanoid" id="B8E2T3"/>
    <dbReference type="OMA" id="FRMNLFN"/>
    <dbReference type="OrthoDB" id="974216at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="367" mass="40186" checksum="1F7C0208433D7BCD" modified="2009-03-03" version="1">MRNREFIENLILNIISPTISIFIALFFGGIIIYLLGHNPIETYKEVINFALGNPNGWGYVLFNATSFIFAGLAVAVAFKAGLFNIGAEGQILVGGFVSAIAGLYIAPLFPPFLHLFITLLFAAIGGALWAFIPAILKAKLGAHEVINTIMMNWIGYALTNYLVINTFREKGVVYPLPQTAKLPASATLPKLFALFQKVGINIPESNPLNSSLIFAVLAVLFTYYLLWRTKLGYEIRALGLNPYASENAGISSQKIIFVSMLISGALAGLASINDVLGYRYRFLDNFTHGMGFTGIAVALLGKNHPAGIVFSAFLFGALDRMAIGMDVFTHIPREIISVLQAVIILTIVVSNEVLIRFLKRRRKTIYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2U8</accession>
    <name>B8E2U8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1169</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583530.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353062.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1169"/>
    <dbReference type="EnsemblBacteria" id="ACK42448">
        <property type="protein sequence ID" value="ACK42448"/>
        <property type="gene ID" value="Dtur_1169"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1169"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_2_1_0"/>
    <dbReference type="InParanoid" id="B8E2U8"/>
    <dbReference type="OMA" id="VAEQCEK"/>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="66"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="269"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK42448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="400" mass="45830" checksum="2884B15D1DCCDD5C" modified="2009-03-03" version="1">MPSYRYVAKDLQGKIYKGILEASSEREVRKLLKARKLYVVSIKKETGLWKTLTYKKKVTLPELVLFTSQFATLLRSGIILTECLSTLASQTDNAYFKDVLLDVRKNVDAGLSLSEALSKYPDVFPKIFISLVRTGEVTGSLDLMLDRLSKYFDSQHELREKIKSATTYPTIVIIAAIVVVIFMLTFVVPTFQRIYGRTNVPLPFPTRITIFLGNFVKNNILIILVLLALLIAGARQSLRNKKIKRWWDENKLKIPKIGKLWRQVLLTRFSGTFYVLLTGGILITQSLEILEDVIGNLYFSEHLRKILSGVLEGRNLSDMMDEEVFTPLLKQMVVIGERSGRLDTMLEEYTKFAEREIDIATKRLTAMIEPALTIFLGVVVFFIAISMYLPMFNMVRLFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2V0</accession>
    <name>B8E2V0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583532.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353064.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1171"/>
    <dbReference type="EnsemblBacteria" id="ACK42450">
        <property type="protein sequence ID" value="ACK42450"/>
        <property type="gene ID" value="Dtur_1171"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1171"/>
    <dbReference type="HOGENOM" id="CLU_1710363_0_0_0"/>
    <dbReference type="OMA" id="HIFYWLR"/>
    <dbReference type="OrthoDB" id="2124035at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="153" mass="18278" checksum="8AE96A41280EF461" modified="2009-03-03" version="1">MKIFSIFSLRRYKRGIIYVILISVLLFSLSMLFHIFYWLRVNTFILSHEVIINSKYALELSITKGERIIYSFEYSPKLNTILFYWIYGEKSKKVYLQPQLLPSEIKGISPTNTYTFYFDNGNLYPEGEILFSTYFYKKGVKFYKNGRVVFVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2V3</accession>
    <name>B8E2V3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal methylation motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1174</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583535.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353067.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1174"/>
    <dbReference type="EnsemblBacteria" id="ACK42453">
        <property type="protein sequence ID" value="ACK42453"/>
        <property type="gene ID" value="Dtur_1174"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1174"/>
    <dbReference type="HOGENOM" id="CLU_480403_0_0_0"/>
    <dbReference type="OMA" id="IMYYPAP"/>
    <dbReference type="OrthoDB" id="740009at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001322">
        <property type="entry name" value="Lamin_tail_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036415">
        <property type="entry name" value="Lamin_tail_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00932">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74853">
        <property type="entry name" value="SSF74853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51841">
        <property type="entry name" value="LTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="LTD" evidence="2">
        <location>
            <begin position="328"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="530" mass="59280" checksum="3F7F275BD17B5F95" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2W2</accession>
    <name>B8E2W2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-terminal methylation motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583544.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353076.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1183"/>
    <dbReference type="EnsemblBacteria" id="ACK42462">
        <property type="protein sequence ID" value="ACK42462"/>
        <property type="gene ID" value="Dtur_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1183"/>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1419462_0_0_0"/>
    <dbReference type="OMA" id="FMQYGML"/>
    <dbReference type="OrthoDB" id="2118303at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="191" mass="21545" checksum="398FB5BC57F44A30" modified="2009-03-03" version="1">MRKGFSLIELYIVIAVLAIIAIASIPTLRNFYERKTLENIMWQLAQDLRIAREKAIVQQQDLIAYIGEDEYYIEFMQYGMLQNPQIYNIHFVPGDANSRYFKIVKLPKNIKLQFISPTVSINGKNYLGVVFKAGGNANEIRGQAKIVNLLSGRTLYSDSNIDNNGVVITGKSMSINLSYSIKIMATGKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2X8</accession>
    <name>B8E2X8_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_1199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583560.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353092.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1199"/>
    <dbReference type="EnsemblBacteria" id="ACK42478">
        <property type="protein sequence ID" value="ACK42478"/>
        <property type="gene ID" value="Dtur_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1199"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1236"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_0"/>
    <dbReference type="InParanoid" id="B8E2X8"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008834">
        <property type="term" value="F:di-trans,poly-cis-decaprenylcistransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002094">
        <property type="term" value="F:polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="21"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="194"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="244" mass="28777" checksum="07052307E9E117DB" modified="2009-03-03" version="1">MKEIEVPKEKLPKHIAFIMDGNGRWAKERNLPRLIGHREGALVVEKISEIAFNWGINYLTFFAFSTENWRRPREEVEGLMQLLDESIDKFKDKLVKNKIRLKVIGNLDELPTYLQRRINYVVEETKNGKDKVLTVALNYGGRWDILEAVKKIALQVKENNLKIEDVNENLFSSFLSTYDLPEPDLLIRTSGEYRISNFLLWQIAYTELWFTPKYWPDFNEEDLRMACLDFAKRKRRFGGLENNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Y4</accession>
    <name>RIMP_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimP</name>
        <name type="ordered locus">Dtur_1205</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583566.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353098.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2Y4"/>
    <dbReference type="SMR" id="B8E2Y4"/>
    <dbReference type="STRING" id="515635.Dtur_1205"/>
    <dbReference type="EnsemblBacteria" id="ACK42484">
        <property type="protein sequence ID" value="ACK42484"/>
        <property type="gene ID" value="Dtur_1205"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1205"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1243"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_2_2_0"/>
    <dbReference type="InParanoid" id="B8E2Y4"/>
    <dbReference type="OMA" id="YIHVSLY"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000384644" description="Ribosome maturation factor RimP">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <sequence length="156" mass="18258" checksum="5705BB40C42FF58E" modified="2009-03-03" version="1">MKDQIYMELLKKLKDIVEPICEKYSYELVDLEYRREPHGWVLRVYIDKVGGVTVEDCAYISEKISKELDIKDPIPHSYILEVSSPGLDRPLKRKRDFERHIGEKVNITLLEEIEGKKKVEGKIFKVDEKNVTLKVDDSLMVIPIEKIKKALLIVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8E353</accession>
    <name>B8E353_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1722 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584002.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353541.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1655"/>
    <dbReference type="EnsemblBacteria" id="ACK42927">
        <property type="protein sequence ID" value="ACK42927"/>
        <property type="gene ID" value="Dtur_1655"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1655"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1705"/>
    <dbReference type="eggNOG" id="COG1683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076318_0_1_0"/>
    <dbReference type="InParanoid" id="B8E353"/>
    <dbReference type="OMA" id="CGLERVK"/>
    <dbReference type="OrthoDB" id="1757306at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013560">
        <property type="entry name" value="DUF1722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017087">
        <property type="entry name" value="UCP037004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08349">
        <property type="entry name" value="DUF1722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037004">
        <property type="entry name" value="UCP037004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1722" evidence="1">
        <location>
            <begin position="193"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="316" mass="36965" checksum="63281DF04C2F79B6" modified="2009-03-03" version="1">MRNFTKPRIVYSACLNSEPVRYDGGIIKDSFALKLKEYCEIITVCPEVSIGLGVPREKIIVYVEENRLGIYQPKTGLDLTDKILDFSENFLNTLPEIDGFLLKSKSPSCGLSNTMIYKDREGKIFHSKGKGIFAQKVLEKFPYIPAEDEGRLRNPEIRERFLTRIFALSELRNLKNKDNTKVKDLIEFHQNNKYLLMVYSQKHLKELGNLLANQSKYPFEELIEKYALLFKEALSTNLKRGNHVNAIFHIYGYFSRKLKAGEKNHFLHLLDLYRRAKINLSPLVEILRSWAYRFDDQYLLNQTYLNPYPNELSYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>B8E378</accession>
    <name>B8E378_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ROK (NagC/XylR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584027.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353566.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1680"/>
    <dbReference type="EnsemblBacteria" id="ACK42952">
        <property type="protein sequence ID" value="ACK42952"/>
        <property type="gene ID" value="Dtur_1680"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1680"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_13_1_0"/>
    <dbReference type="InParanoid" id="B8E378"/>
    <dbReference type="OMA" id="FFIRHQQ"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="376" mass="42531" checksum="E09C80E62E4E8B75" modified="2009-03-03" version="1">MREGRKPEYIGLYNKNLVLEILIKIGPKSRAELARISKLTKTAISEIVDELIEKNILIEVGKVETSRGRRPTKLTINPELKVLAIDLSGLEGRVGVVNANGKIEEDRYHPIEKKEDLFQLIDPLLIKYKNNVVAISLSVPGIIDKYNGEVILSVGLNWKNFKLKEFLKEKYPNYPIYMEKDTNSGLLSELWFGEGKNFNILFYLLFEKGIGLGIYYKGNIIEGFNNIEGEIGHTIVSKEIGEKCWCGNKGCLESIASIPKIQEKILDLGSLEKALINYIQDNKNSVLQEIFEFLGISLANTIHILAPEAICISGNRGMTKDILNLFTKILKDKVDKYVFEYLKDKIYFYTSPLGNDGLLIGAGILGFINYFRELLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3D9</accession>
    <name>B8E3D9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584088.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353627.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1741"/>
    <dbReference type="EnsemblBacteria" id="ACK43013">
        <property type="protein sequence ID" value="ACK43013"/>
        <property type="gene ID" value="Dtur_1741"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1741"/>
    <dbReference type="eggNOG" id="COG0395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_1_2_0"/>
    <dbReference type="InParanoid" id="B8E3D9"/>
    <dbReference type="OMA" id="AWLLKGY"/>
    <dbReference type="OrthoDB" id="1510342at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="76"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK43013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="281" mass="31467" checksum="4F68C42B32D937A4" modified="2009-03-03" version="1">MKYLFYSLKWLILLVILVFFLFPVYWLVITAFKPASDWFKWPPMIFPRTLTLENFTGGGSFYGSTTTSIENITPYLRNSTAISLITSILAVIISALAAYSISRFKTGGRKFANWIISVRMLPPIASALPLYILFKNLKLLDTWTALIMVYLVFTIPFSTWVLISFFNGIPKELDEAAYIDGASSLSTFFHVVLPLSAPGLAAMMTLSFVTCWGEFLLALILTSTANSQTLPVYLGRYITGWRIAWGPLAAAGIVTMLPAVIFSFTMQRYLLRGLTFGAVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E3E7</accession>
    <name>B8E3E7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Dtur_1749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584096.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353635.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1749"/>
    <dbReference type="CAZy" id="GH4">
        <property type="family name" value="Glycoside Hydrolase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK43021">
        <property type="protein sequence ID" value="ACK43021"/>
        <property type="gene ID" value="Dtur_1749"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1749"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1801"/>
    <dbReference type="eggNOG" id="COG1486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045951_1_1_0"/>
    <dbReference type="InParanoid" id="B8E3E7"/>
    <dbReference type="OMA" id="EYVPWYR"/>
    <dbReference type="OrthoDB" id="277080at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001088">
        <property type="entry name" value="Glyco_hydro_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022616">
        <property type="entry name" value="Glyco_hydro_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32092">
        <property type="entry name" value="PTHR32092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02056">
        <property type="entry name" value="Glyco_hydro_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11975">
        <property type="entry name" value="Glyco_hydro_4C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00732">
        <property type="entry name" value="GLHYDRLASE4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_4C" evidence="7">
        <location>
            <begin position="202"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK43021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="466" mass="53938" checksum="73FBEBE2BE2CDCE9" modified="2009-03-03" version="1">MKIAIVGAGSIRFSLQIIGDIAKTPRLNGTLISMVDVHEERLNASYILAKKYIEELEADLRFEKTKSLEEGIEGADFIINTALPFPQGHEDGFIKYDLITQIGEKHGYYRGIDSQELNMVSTYTYGLISYYDLKLALDIAKAMKKYAPSSWLLQTANPVFEISQLLNRLTDIKVVGICHGFHGVYEVFNSLRLDPKEVDWQVAGVNHGIFLNRFLYRGKNAYPLLDEWIEKEAQNWEPKNPWDLQMSPAVIDMYKFYGMLPIGDTCRNGTWKYNYNLETKKKWYGKFGGIDNEIERPKFHEELRKGRRKIIELAKEVEKDKSIKLMDIWPELFNRDKLSGEQHVHFINSITGGGNSRLILNVPNRGTISGIPDDVVVEIPVWVDESGIKHEKIEPDLTHRIKIFYLIPRILRMEWALEGFISKDVKVLEEILIRDPRTKSYEQVLSVLDEILSQPFNKELRDYLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYM4</accession>
    <name>B8DYM4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352020.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0068"/>
    <dbReference type="EnsemblBacteria" id="ACK41406">
        <property type="protein sequence ID" value="ACK41406"/>
        <property type="gene ID" value="Dtur_0068"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0068"/>
    <dbReference type="HOGENOM" id="CLU_1755930_0_0_0"/>
    <dbReference type="OMA" id="HYDPPTL"/>
    <dbReference type="OrthoDB" id="2120052at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="148" mass="17332" checksum="6038D43B7BB80C3E" modified="2009-03-03" version="1">MEKRDIKELEKKIRRIVQRMNIEDIVRKAIEHYDPPTLNGIVALDLNTGEIFSYSSIEEPAFSRSIVILYKLSVSRFPLEELFSERELNLAKMILGEAWNLSARDIARTLGKEFKEVEDKIFNTIMKEDDPSEEIIENVLEYVRRVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>B8DYR5</accession>
    <name>B8DYR5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582533.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352061.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0114"/>
    <dbReference type="EnsemblBacteria" id="ACK41447">
        <property type="protein sequence ID" value="ACK41447"/>
        <property type="gene ID" value="Dtur_0114"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0114"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1007349_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="276" mass="30056" checksum="9D595819824B60CF" modified="2009-03-03" version="1">MPQLSYATLEGIITHRDKLPIEGAKVIIASFNPCYSGAVVDDISRKGVIVITSVNANQTNRFGWAGEWRNALLGGTSDNRTDRNGDGFISMTEAYEWVAVKSQAYNPIVITSAQINGKAISSCAVNLAKDNFLLYLTDDQGRAVPNAWVQWIAFVPSPTQEVIGGVLIASHGQHISFPRLSSTPVIVTNAQKDGKALISGAQNNAPDGFDLCILDDSGRTVSGAWVLWMVVVPNSKNGFKGEVRMRSNGQNIQFTPSFSKGPVYVYRHNLELWLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ39</accession>
    <name>B8DZ39_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582750.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352279.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0353"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41665">
        <property type="protein sequence ID" value="ACK41665"/>
        <property type="gene ID" value="Dtur_0353"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0353"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.373"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_782413_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZ39"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="354" mass="40782" checksum="660BA6E826EB3099" modified="2009-03-03" version="1">MKGKDLISVVIPAYNAEHFIKNAILSIFKQSYRPIEIIVINDGSTDHTLDIIESLENLVPNKEIYMKIINLKENKGAANALNVGFKEANGSYICWLSADDIFINPRKLEKQIFTMKKNKTLWSFFEKYYIGESINNAILMGNSYKSKILSCLSSISTDFLFLFIIYSNPINGSSLMFHRNCLENYGSFDPLLRNVDADGDLLMRYALLKIKSAIIKDVGVFYTQHPFQTSKKIKEMIYGCDLTRVRILKLLEEEEILKELSKLIALFLLSAIYSGKKIHLAYPFTSEFLINYMINNSPGLKRSKLLNKALIETTQHIESLGLSRDNFYKDVEEKSKSDVFENFKILLRERRKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZ96</accession>
    <name>B8DZ96_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582914.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352443.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0539"/>
    <dbReference type="EnsemblBacteria" id="ACK41829">
        <property type="protein sequence ID" value="ACK41829"/>
        <property type="gene ID" value="Dtur_0539"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0539"/>
    <dbReference type="HOGENOM" id="CLU_2272906_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="102" mass="11327" checksum="102506BEF5E84A19" modified="2009-03-03" version="1">MKKLLIFLGVAILTLVVVFGVSNITKQKVYAQTSTLTQTSTTIQTQQKAVDNDQEIKDDQEIEKGEVEEAKEVKEIEDDNLPNGGHQDPEGVNVDHQFEGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZB6</accession>
    <name>B8DZB6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase (Quinone)</fullName>
            <ecNumber evidence="7">1.6.99.5</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="1.6.99.5" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582934.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352463.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0559"/>
    <dbReference type="EnsemblBacteria" id="ACK41849">
        <property type="protein sequence ID" value="ACK41849"/>
        <property type="gene ID" value="Dtur_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0559"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.595"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_0"/>
    <dbReference type="InParanoid" id="B8DZB6"/>
    <dbReference type="OMA" id="AFMNRTL"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="567"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="597"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="624" mass="69044" checksum="79F83B96A26A9075" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZE9</accession>
    <name>B8DZE9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamine--scyllo-inositol transaminase</fullName>
            <ecNumber evidence="4">2.6.1.50</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.50" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582967.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352496.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0594"/>
    <dbReference type="EnsemblBacteria" id="ACK41882">
        <property type="protein sequence ID" value="ACK41882"/>
        <property type="gene ID" value="Dtur_0594"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0594"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.630"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_7_2_0"/>
    <dbReference type="InParanoid" id="B8DZE9"/>
    <dbReference type="OMA" id="QVHYKPI"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047310">
        <property type="term" value="F:glutamine-scyllo-inositol transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080100">
        <property type="term" value="F:L-glutamine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="372" mass="41941" checksum="F812E2406AFEDB86" modified="2009-03-03" version="1">MEKIPMSAPDLDETDIQEVLEVLRSGRLALGPKAREFEEMMANYIGVKCAVAVSSGTAGLHILVRALGIGPGDEVLVPSFTFAASVNVILYEKAIPVFVDIEPETYNLDPDDLERKITKKTKAIMAVDIFGHPAEWDKILEIADKYNLKVIDDSCEALGAEYKGKKIGQFGDCACFAFYPNKQMTTGEGGIIVTNNSEIAKIARSLRNQGRGEMGSWLEHERLGYNYRMDEMSAALGVSQLKRIETFLEKREKVAKMYTEKLKNYSWVRVPTVKPYVRMSWFVYVITLEDGLDRDIVIRELEKEGIPARGYFSPIHLQPYIRDMFGTKEGMLPVTENISKRTLALPFHNNLKEEEVDEVVSTLKKVVEKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZG2</accession>
    <name>B8DZG2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein DxTHG motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582980.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352509.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0607"/>
    <dbReference type="EnsemblBacteria" id="ACK41895">
        <property type="protein sequence ID" value="ACK41895"/>
        <property type="gene ID" value="Dtur_0607"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0607"/>
    <dbReference type="eggNOG" id="COG1517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_642108_0_0_0"/>
    <dbReference type="InParanoid" id="B8DZG2"/>
    <dbReference type="OMA" id="HAGLICE"/>
    <dbReference type="OrthoDB" id="2111805at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="419" mass="49717" checksum="46EE9F4758424F90" modified="2009-03-03" version="1">MTKILCSFVPKDSKEIPYHIGGKIYKGKSTIEALCSYYLSNEEDIKVILIKPETIDIKEEIELRKKLISLGVNEDKIITQEIPMKGFYENKYYDIDNTIIADFIFLTLNENTDDKAEEVILDVSRGINFLVLTAVDAFRRFIVAQKARYYNKENKLDKLEYFYVYLTPKKPNFEEGEISLEKASAPFFFDFFTKKGIPFNFEAEKLDYFKEFNFTKNIISHVNSCITAIKRGFALAYLTFIPWSEIKDLISLSHEKLSLKRLKELVKEFSYENENQKKVKFKMNYPLGNLWIYVHLLNTFYEIYKDYENQITYEENRKWVPLSTLKNFNENVIKKLFQENSASIILSREINDFEQTFKKGEIKKTGRSPNYERNFNAHAGLICEFIDQNPQNFSISYRFNETKKDKIEKYIEYFLEHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZL1</accession>
    <name>B8DZL1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_0659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the BioY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583029.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352558.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0659"/>
    <dbReference type="EnsemblBacteria" id="ACK41944">
        <property type="protein sequence ID" value="ACK41944"/>
        <property type="gene ID" value="Dtur_0659"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0659"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.697"/>
    <dbReference type="eggNOG" id="COG1268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077931_1_1_0"/>
    <dbReference type="InParanoid" id="B8DZL1"/>
    <dbReference type="OMA" id="AGYLWSY"/>
    <dbReference type="OrthoDB" id="1691691at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003784">
        <property type="entry name" value="BioY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34295">
        <property type="entry name" value="PTHR34295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02632">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016661">
        <property type="entry name" value="BioY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR016661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK41944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="171" mass="19093" checksum="A27B2C96F64FF664" modified="2009-03-03" version="1">MKVRQIPYLALGLALLILGSYLSFYLPFTQIPFTLQVFFLFLITLYFSPVETFFIVFAYLLLGGIGLPVFAGGKGGLNALFGPTGGYLFGFLIGGIIISMVKKYSEILALFLGILIIYLTGSIWLSNSLKISYYKALITGVLPFIPYDFAKALISYLIWQRLKKQLKTNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZL4</accession>
    <name>B8DZL4_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5668 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583032.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352561.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0662"/>
    <dbReference type="EnsemblBacteria" id="ACK41947">
        <property type="protein sequence ID" value="ACK41947"/>
        <property type="gene ID" value="Dtur_0662"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0662"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.700"/>
    <dbReference type="HOGENOM" id="CLU_073800_0_0_0"/>
    <dbReference type="OMA" id="NMYGFLP"/>
    <dbReference type="OrthoDB" id="1687355at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043726">
        <property type="entry name" value="DUF5668"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18917">
        <property type="entry name" value="DUF5668"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5668" evidence="2">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK41947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="296" mass="34133" checksum="A2B451FB32BCE49C" modified="2009-03-03" version="1">MKRRISLLGIFLILSGLLLLLSELRVIHFYWKDLLMLWPLIFIFWGLDLLIGEKRWGSWVTILIIFLLVFFIVFLSTYGRPFFRGRGHDFYYKEWRYPFKENVKVLNLDISTGIRSVILEGVKNKEDLIYIKSNSDFYINKIKEEEQNGELSLSLKIENKELEFGFFYMSNADQINLNISSDIFLNLNFERGVGNAVLNMKNFKLRNLSVKGGVGNLKVYLPKFSCYVEVEGGVGSIEVYIPENVILDLSTEAGIGRISVDKNIEQGKGGEKEIIHLRVRSGIGNIKILSEKKEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZS6</accession>
    <name>B8DZS6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583094.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352623.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0725"/>
    <dbReference type="EnsemblBacteria" id="ACK42009">
        <property type="protein sequence ID" value="ACK42009"/>
        <property type="gene ID" value="Dtur_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0725"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1198064_0_0_0"/>
    <dbReference type="OMA" id="SHQYYFL"/>
    <dbReference type="OrthoDB" id="2220741at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="242" mass="27730" checksum="265F9D9472ACA2A8" modified="2009-03-03" version="1">MTLGIVTTGRIGEIGRVSNVSKKLEGISIALWDKIFDLYVVLLLALPGIYYFKGLFLSILYVLFLIVIFFLLIKPEYLESLKRFPILRSYPQLVNGLKAIERKIFIVNLLITFVAYFLVVFEGYFLGKAFDIDNFFAFLYGYPLVMLVNLVPMTIAGLGLREGTAILLLNKFSIPSNVAFNVSFLIFLLNTALPAIWGIFAMYLEEIKKSIYKTDVWAYLITLFGGFLRFYKIGVMDRHYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZT4</accession>
    <name>B8DZT4_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ApbE family lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583102.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352631.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0734"/>
    <dbReference type="EnsemblBacteria" id="ACK42017">
        <property type="protein sequence ID" value="ACK42017"/>
        <property type="gene ID" value="Dtur_0734"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0734"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.773"/>
    <dbReference type="eggNOG" id="COG2122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074757_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZT4"/>
    <dbReference type="OMA" id="YGVCTSS"/>
    <dbReference type="OrthoDB" id="1979718at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003374">
        <property type="entry name" value="ApbE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007183">
        <property type="entry name" value="UPF0280"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006421">
        <property type="entry name" value="UCP006421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143631">
        <property type="entry name" value="SSF143631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="243" mass="26995" checksum="9A0F8D9B9CB9810B" modified="2009-03-03" version="1">MSSDKYIERTYRKYMRAPDLVSFQVKVQESDLYILAKKDLRKEAEKLLIFYRRQIEDYILKDPVFKLTLTPYKPKGNAPEIVKEMSFWSEKAGVGPMASVAGAIAEYIGKELLNYSDEIIVENGGDIFISTKRERKVAIFAGESPWSNKIGVLIPPGTTFGVCTSSGTVGPSLSFGVADAVMIVSPSAIFSDALATTLGNMIKTDKDIEVALEFAQRFPEVIQVVIVYGKHLGVWGNLKLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8DZW9</accession>
    <name>B8DZW9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583137.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352666.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0770"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK42052">
        <property type="protein sequence ID" value="ACK42052"/>
        <property type="gene ID" value="Dtur_0770"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0770"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005603_1_0_0"/>
    <dbReference type="InParanoid" id="B8DZW9"/>
    <dbReference type="OMA" id="PYTHPIL"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="2">
        <location>
            <begin position="8"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="829" mass="98435" checksum="8D607AD2B9129152" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>B8E076</accession>
    <name>B8E076_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-terminal methylation motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Dtur_0878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583243.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352773.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0878"/>
    <dbReference type="EnsemblBacteria" id="ACK42159">
        <property type="protein sequence ID" value="ACK42159"/>
        <property type="gene ID" value="Dtur_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0878"/>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_7_1_0"/>
    <dbReference type="InParanoid" id="B8E076"/>
    <dbReference type="OrthoDB" id="2044924at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="2">
        <location>
            <begin position="29"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACK42159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="142" mass="15506" checksum="02A8C81CBB896E3C" modified="2009-03-03" version="1">MRREKGFTLIELMVVIVIIAILAAVALPNFMGATERARESAVRSAVKTLQTALEMYATDNQGYYPDYIYTLKNGNYLPGGKFPNNPATNAEYGFTANNNDSGESAYKIVYTVSTDHASYTITGYGKDNQKVVIQVSSAGTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E085</accession>
    <name>B8E085_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acylmannosamine kinase</fullName>
            <ecNumber evidence="1">2.7.1.60</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.1.60" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583252.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352782.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0887"/>
    <dbReference type="EnsemblBacteria" id="ACK42168">
        <property type="protein sequence ID" value="ACK42168"/>
        <property type="gene ID" value="Dtur_0887"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0887"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.925"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_0"/>
    <dbReference type="InParanoid" id="B8E085"/>
    <dbReference type="OMA" id="VNVPGWR"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009384">
        <property type="term" value="F:N-acylmannosamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="317" mass="34228" checksum="F1F02A6FFA068593" modified="2009-03-03" version="1">MKRYLALDIGGTKIACGRFTEDGILEEKIVSPTKAERGYRKVLEDIILNLLKLKTEDTIALGIGTAGPLDRIKGEIYSPPNLPGWDGVPLKRDLYESLKIPIFMDNDANAACLGEYLFGAGKGVKNMVYITVSTGIGGGIIVNGGLLHGVRDSAGEVGHQTILPDGPLCNCGNRGCLEALSSGTAIAKRAMEEIKHNKDTILKRWAEREELTAKHVREAMLMGDKVAKEIWDSAMEYLGIGVGNIITIVSPEKVVIGGSVGLSGEDVIEKIKEVIKKRVFLVPTDKVEIVPARLREDVGLYGAFAVALTEMRNKEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0E1</accession>
    <name>B8E0E1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplT</name>
        <name evidence="7" type="ordered locus">Dtur_1312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583668.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353200.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1312"/>
    <dbReference type="EnsemblBacteria" id="ACK42586">
        <property type="protein sequence ID" value="ACK42586"/>
        <property type="gene ID" value="Dtur_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1312"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1357"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_0"/>
    <dbReference type="InParanoid" id="B8E0E1"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="113" mass="13376" checksum="96F03B66B5E5E5BD" modified="2009-03-03" version="1">MRVKGGTITRKRHKKILKLAKGYRGRRSRIFKIANQSVIKALYDAYIDRRRKKREFRRLWIVRINAALRNYGLSYSKFMGLLRKANIKLNRKVLADLCVNEPKAFEALVNKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0J9</accession>
    <name>B8E0J9_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartokinase</fullName>
            <ecNumber evidence="13">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Dtur_1370</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583724.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353258.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1370"/>
    <dbReference type="EnsemblBacteria" id="ACK42644">
        <property type="protein sequence ID" value="ACK42644"/>
        <property type="gene ID" value="Dtur_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1370"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1415"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_3_2_0"/>
    <dbReference type="InParanoid" id="B8E0J9"/>
    <dbReference type="OMA" id="DMIVQTI"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="265"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ACK42644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="407" mass="43802" checksum="76658743273B5F96" modified="2009-03-03" version="1">MSLIVQKYGGTSVGSIERIKNVAQRIAKYYHSGHKLVVVVSAMGDTTDELIDMAEKLNPNPNPREMDFLLSSGERISAALTAMALQNLGIPAIALSGKQAGIMTDSVFTKANIKKIDPKRILEELEKGKVVIVAGFQGYEPEKGDVTTLGRGGSDATAVALAAVLKADICEIYTDVDGIFTADPRVVPNAKKLEFISYEEMLEMASQGAQVMQLRSVDLAATYHVPVVVRSSFNENSGTLIGEVKEVESKQKVKGIAHNKNIAKITIIGVPDKPGIAHKIFAPLGEKSINVDDIVQNVSKEGITDLSFTVSERELNEALKVVQEVAKEIGAKKVLYDNNVGKVSIVGWGIQSTPGIAAKMFGILASEGINIEMITTSEIKITCIIRRDLVEKAVRALHDGFNLGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0P1</accession>
    <name>B8E0P1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Dtur_1789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584135.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353675.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1789"/>
    <dbReference type="EnsemblBacteria" id="ACK43061">
        <property type="protein sequence ID" value="ACK43061"/>
        <property type="gene ID" value="Dtur_1789"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1789"/>
    <dbReference type="eggNOG" id="COG0515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015582_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0P1"/>
    <dbReference type="OMA" id="YAPSEQC"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018105">
        <property type="term" value="P:peptidyl-serine phosphorylation"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007890">
        <property type="entry name" value="CHASE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05226">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01080">
        <property type="entry name" value="CHASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="380"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ACK43061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="666" mass="76687" checksum="122FF630E696EB5F" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Q3</accession>
    <name>B8E0Q3_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase zinc-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK43073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012584147.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353687.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1801"/>
    <dbReference type="EnsemblBacteria" id="ACK43073">
        <property type="protein sequence ID" value="ACK43073"/>
        <property type="gene ID" value="Dtur_1801"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1801"/>
    <dbReference type="eggNOG" id="COG1913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108521_2_0_0"/>
    <dbReference type="InParanoid" id="B8E0Q3"/>
    <dbReference type="OMA" id="RSVYDCD"/>
    <dbReference type="OrthoDB" id="1765947at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01842">
        <property type="entry name" value="Archaemetzincin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012091">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="PTHR15910"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07998">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005785">
        <property type="entry name" value="Zn-prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK43073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="177" mass="20649" checksum="459AA752745AEA42" modified="2009-03-03" version="1">MEKYIYIVPIGNIEKDLLDFLKKKIEEVFNIKVKDYKNLSIPEEAYNPQRKQYYSYHFLNLLSSLNPLDAYKILGITNVDLYTDYLNFIFGEAIVNGKECVISIARLDNKFYNLPADNELLKLRTLKEAVHELGHTMGLKHCETPSCVMYFSNTLADTDKKSYNFCPKCKSRLSNFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0R8</accession>
    <name>B8E0R8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-bound metal-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_1381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583733.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353269.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1381"/>
    <dbReference type="EnsemblBacteria" id="ACK42655">
        <property type="protein sequence ID" value="ACK42655"/>
        <property type="gene ID" value="Dtur_1381"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1381"/>
    <dbReference type="eggNOG" id="COG1988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097802_3_1_0"/>
    <dbReference type="OMA" id="FTYQGIR"/>
    <dbReference type="OrthoDB" id="1667936at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK42655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="231" mass="26395" checksum="75B51028AE99AFCC" modified="2009-03-03" version="1">MIYKTHISLNMLLLQAILRISNIPIQEILTPWGLGISVGTLVGTFIPDIDAPKSEISKRILPAKTLLNMLIPLLSFILSFSLFTFLDLKSTLNTIAQKSIFFLLIFIGVLLILNLIFNSLLKPLFEHRGLLHSLTGLTFLNILLSIFYINNLKNLPLNLSYFYNGFYTGINIGYLGHIIGDFFTYQGIRPFYPVKWKISLRIFRTNSLQEKVLFYILSLANLILLLQNILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0V5</accession>
    <name>B8E0V5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ordered locus">Dtur_1418</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583770.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353306.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1418"/>
    <dbReference type="EnsemblBacteria" id="ACK42692">
        <property type="protein sequence ID" value="ACK42692"/>
        <property type="gene ID" value="Dtur_1418"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1418"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1465"/>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_0"/>
    <dbReference type="InParanoid" id="B8E0V5"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="OrthoDB" id="923547at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046084">
        <property type="term" value="P:adenine biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="70"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="186"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ACK42692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="361" mass="40513" checksum="222F75BBAD77D33B" modified="2009-03-03" version="1">MFWKEDGKKRKGKAITYSLSGVSINKVERALEEVKGYIVSTYKPYVFNYWNSFASVIKIPFQEYKNPLIITSTDGVGTKLIIALKHNRLDTIGDDLLAMNVNDILTAGAKPLIFMDYFAGSKIDPEVYKRVIISIANACKKVDCSLVGGETAEMPGIYRGKEIDLVGFVVGIVEEENLLPKMDRIKEGNVLIGVASSGLHSNGYSLVRYILRKKRISLKKKIDGYDLLEEILRPTKIYPPVVLPLLEKYRDNILGIAHITGGGIPGNLPRILPKNIQAEIDSSSWDIPWIFKFFIKKGNLTWKEAFRVFNMGIGLILIVSGRAEEILIDLKDLGEKAYIIGELNKGERGVKIAWKENVLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Y9</accession>
    <name>B8E0Y9_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583804.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353340.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1452"/>
    <dbReference type="EnsemblBacteria" id="ACK42726">
        <property type="protein sequence ID" value="ACK42726"/>
        <property type="gene ID" value="Dtur_1452"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1452"/>
    <dbReference type="HOGENOM" id="CLU_2355238_0_0_0"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="96" mass="11348" checksum="1820A0581D1A1962" modified="2009-03-03" version="1">MKKFLVFLFLILVVIFLFSFKNLLEIYSLWGKDFAVLIVYNPNFLKEHSYIMNAYRSVLEEEGVIYKEVSIFNLITFDPKIVADFKKIIIFPNGLN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>B8E0Z3</accession>
    <name>AROQ_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="1">3-dehydroquinase</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroQ</name>
        <name type="ordered locus">Dtur_1456</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583808.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353344.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E0Z3"/>
    <dbReference type="SMR" id="B8E0Z3"/>
    <dbReference type="STRING" id="515635.Dtur_1456"/>
    <dbReference type="EnsemblBacteria" id="ACK42730">
        <property type="protein sequence ID" value="ACK42730"/>
        <property type="gene ID" value="Dtur_1456"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1456"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1506"/>
    <dbReference type="eggNOG" id="COG0757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090968_1_0_0"/>
    <dbReference type="InParanoid" id="B8E0Z3"/>
    <dbReference type="OMA" id="AYTHYSY"/>
    <dbReference type="OrthoDB" id="1872106at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000118277" description="3-dehydroquinate dehydratase">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="101"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <sequence length="145" mass="16636" checksum="E953A600218C06CB" modified="2009-03-03" version="1">MIKVLVLHGPNLNLLGVREPNIYGRVDFQTLNNLILQKAKEREIEVEIKQSNFEGQLIDWIQEYRDWADAIIINPGALTHYSYSLRDALLAFGKPVIEVHISNIYKREEFRHHSVIAPVALGQISGFGVNSYLLALEAIFLYFNK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E137</accession>
    <name>VATB_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpB</name>
        <name type="ordered locus">Dtur_1500</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583852.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353388.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E137"/>
    <dbReference type="SMR" id="B8E137"/>
    <dbReference type="STRING" id="515635.Dtur_1500"/>
    <dbReference type="EnsemblBacteria" id="ACK42774">
        <property type="protein sequence ID" value="ACK42774"/>
        <property type="gene ID" value="Dtur_1500"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1500"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1549"/>
    <dbReference type="eggNOG" id="COG1156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_0"/>
    <dbReference type="InParanoid" id="B8E137"/>
    <dbReference type="OMA" id="ICELRTP"/>
    <dbReference type="OrthoDB" id="875807at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000119525" description="V-type ATP synthase beta chain">
        <location>
            <begin position="1"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <sequence length="460" mass="51459" checksum="FE64FD76F7D7562F" modified="2009-03-03" version="1">MPKEYTSVSKISGPLVLVENIENVKYGEVVEVKLANGEIRQGQVLEAQEGAALVQMFASTQDLSLKGMRIKFLGHVLEINLSPEILGRTFDGLGRPRDGGPEIIPQKRMDINGSPINPYSRAYPQEFIQTGISAIDGMNTIVRGQKIPIFSGAGLPHATLAAQIARQARLLNEEEKFAVVFGAMGITFEEANFFIENFRSTGALERTVLFINLANDPVIERIATPRFALTAAEYLAFDLDMHVLVILSDMTNYAEALREVSASRKEVPGRRGYPGYLYTDLATLYERAGRIKGKKGSITLLPILTMPEDDRTHPIPDLTGYITEGQIFLSRELHRRGIYPPIDVLQSLSRLMRGGIGEGRTRKDHGDLSNQLYAAYSRGLEAKELAVVLGEAALTEEDVQFLEFAEAFEMEFIKQGEYENRSIFETLNLGWKLLRRLPRASLKRIRPEYLDEFWGKEDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>B8E187</accession>
    <name>B8E187_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Inner-membrane translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583299.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352829.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0934"/>
    <dbReference type="EnsemblBacteria" id="ACK42215">
        <property type="protein sequence ID" value="ACK42215"/>
        <property type="gene ID" value="Dtur_0934"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0934"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.971"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_1_2_0"/>
    <dbReference type="InParanoid" id="B8E187"/>
    <dbReference type="OMA" id="VFWYKLQ"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015803">
        <property type="term" value="P:branched-chain amino acid transport"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="327" mass="35616" checksum="137514688862BAC3" modified="2009-03-03" version="1">MKRNILTLIALIILLVLARLSQGLNPYFYQILIFWGINSILAMSLNLINGFTGQFSIGHAGFMAAGGYLSAALTIYHGDKIIKLLSFMPESISKNIAFFIFLIAGGLFSALLGIIIGIPTLRLKGDYLAIATLGFGEIIRVIIYNMDVVGGARGFPGIPQLTNSVWVMFWAFICFIVLYRMINSSHGRAIISIREDETASEAMGVNTTYYKVLAFSIGAFFAGVAGGLFGHYLMLLHPASFTFMRSVEILLMIVLGGLGSLTGSIIGAFVLTVLPEALRGFSSLRLIIYSLTLIVLMLIRPTGLMGNKEISLGSIVRKLNKRIGNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1A1</accession>
    <name>B8E1A1_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsY</name>
        <name evidence="8" type="ordered locus">Dtur_0948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352843.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0948"/>
    <dbReference type="EnsemblBacteria" id="ACK42229">
        <property type="protein sequence ID" value="ACK42229"/>
        <property type="gene ID" value="Dtur_0948"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0948"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.985"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_4_0"/>
    <dbReference type="InParanoid" id="B8E1A1"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="93"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="94"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="101"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="183"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="247"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="299" mass="33640" checksum="E9CF8511AE7BA090" modified="2009-03-03" version="1">MKLSFWDRLPKIKGFAERLQNIFKFSRVDTELLDELEMELIQSDLGIELTNEIIGEIKKRKISDMQELRDFLFDFFKSILDGLDYKLRLYDNRLNVVIFIGVNGTGKTSTVGKFAYYLKNLGYFPIIAAADTFRAAAIDQIKRWGERVGVDVVAQKEGADPGAVVFNAIEAAKARNKDVLLVDTAGRMHTKSNLVEELKKIEKIVEKTLGYPPSENLVVIDATLGQNVVRQVEIFHNAVNLTGAVLTKLDGTAKGGVIFNVIKRFNIPVKLVTIGEELDDLKPFDPNEFVESFIPEVKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1A9</accession>
    <name>CH60_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperonin GroEL</fullName>
            <ecNumber evidence="1">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-60</fullName>
            <shortName evidence="1">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groEL</name>
        <name evidence="1" type="synonym">groL</name>
        <name type="ordered locus">Dtur_0957</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.</text>
            <dbReference type="EC" id="5.6.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583321.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352851.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E1A9"/>
    <dbReference type="SMR" id="B8E1A9"/>
    <dbReference type="STRING" id="515635.Dtur_0957"/>
    <dbReference type="EnsemblBacteria" id="ACK42237">
        <property type="protein sequence ID" value="ACK42237"/>
        <property type="gene ID" value="Dtur_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0957"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.994"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_0"/>
    <dbReference type="InParanoid" id="B8E1A9"/>
    <dbReference type="OMA" id="PYILINQ"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990220">
        <property type="term" value="C:GroEL-GroES complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051085">
        <property type="term" value="P:chaperone cofactor-dependent protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000130005" description="Chaperonin GroEL">
        <location>
            <begin position="1"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="479"/>
            <end position="481"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <sequence length="538" mass="57898" checksum="5D917B974AE5B9FB" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1G3</accession>
    <name>B8E1G3_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Energy-coupling factor transporter ATP-binding protein EcfA2</fullName>
            <ecNumber evidence="4">3.6.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1011</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.3.-" evidence="4"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583374.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352905.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1011"/>
    <dbReference type="EnsemblBacteria" id="ACK42291">
        <property type="protein sequence ID" value="ACK42291"/>
        <property type="gene ID" value="Dtur_1011"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1011"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1048"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_0"/>
    <dbReference type="InParanoid" id="B8E1G3"/>
    <dbReference type="OMA" id="DIVPLYC"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030946">
        <property type="entry name" value="EcfA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04521">
        <property type="entry name" value="ECF_ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="287" mass="32532" checksum="E18E81F2045D3ED3" modified="2009-03-03" version="1">MALISLKSVSYTYLKDTPLEKEALLNVSLNVEHGERIGILGKTGSGKSTLIQLIGGLIYPTSGEVYVKDKEIRKWNSKELCKIVGVVFQYPEYQFFAETVFEEVAFGPKNVGISEEKIEDCVKSALISVGLSYEEIKDRSPFHLSGGEKRRLAIASILAMDPEVLILDEPTANLDPRGKLQIMNYIDRWVDKKQKTLIIVSHDLDEVMRLVRRVIVLKAGEIIFDGPSERLFMSYDKLEEAELDLPEIVRLVKILQEKGYPIEGAFTVQEIVERILAYKGYKSLWKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1H7</accession>
    <name>B8E1H7_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucosidase</fullName>
            <ecNumber evidence="6">3.2.1.20</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_0171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582587.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352116.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0171"/>
    <dbReference type="CAZy" id="GH31">
        <property type="family name" value="Glycoside Hydrolase Family 31"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ACK41502">
        <property type="protein sequence ID" value="ACK41502"/>
        <property type="gene ID" value="Dtur_0171"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0171"/>
    <dbReference type="eggNOG" id="COG1501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000631_7_2_0"/>
    <dbReference type="InParanoid" id="B8E1H7"/>
    <dbReference type="OMA" id="QGVDCFK"/>
    <dbReference type="OrthoDB" id="469334at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032450">
        <property type="term" value="F:maltose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032513">
        <property type="entry name" value="AGL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
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        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
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        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16338">
        <property type="entry name" value="DUF4968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4968" evidence="4">
        <location>
            <begin position="25"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Gal_mutarotas_2" evidence="3">
        <location>
            <begin position="129"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="5">
        <location>
            <begin position="699"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK41502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="777" mass="92494" checksum="B3B5CBBD5F52D709" modified="2009-03-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1M5</accession>
    <name>B8E1M5_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF362 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582635.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352164.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0221"/>
    <dbReference type="EnsemblBacteria" id="ACK41550">
        <property type="protein sequence ID" value="ACK41550"/>
        <property type="gene ID" value="Dtur_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0221"/>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066599_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1M5"/>
    <dbReference type="OMA" id="QTCCLKT"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF362" evidence="1">
        <location>
            <begin position="94"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="347" mass="38958" checksum="401A9EA4D59BBB63" modified="2009-03-03" version="1">MGNRKKYLTIGLGTLFLLSQSLSKQENLKQESIFKIPNNPIYVAQNSIEVINQERKIPQIVDVGVAKEENIRKSVKKAIELCGGMNFIKPGDTVLIKPNVNSNDPYPGTTNPEVLAEVIEMVKEKGAKRIIVADSSGIPWPNTLKNMEATGILKVAQRAGVEVYALDNMEWIWVKPEVLKYWDRGFRIPKIVKEVDHIINVAVVKTHSIADFTMSLKNFVGFIHRQDRVIMHSSRYLKEMIGELNIAFSPSLNILDASKVFVRGGPAKGEERELGMVIASTDRIACDITGLSLLKLLGTTQEIQNKNMWEHPQIKRAIELGIGINNPDLINLKTSNVDREKLLIRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1S6</accession>
    <name>B8E1S6_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0405</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352323.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0405"/>
    <dbReference type="EnsemblBacteria" id="ACK41709">
        <property type="protein sequence ID" value="ACK41709"/>
        <property type="gene ID" value="Dtur_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0405"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.427"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_0"/>
    <dbReference type="InParanoid" id="B8E1S6"/>
    <dbReference type="OMA" id="RVVVYFY"/>
    <dbReference type="OrthoDB" id="1996723at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="3">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="154" mass="17612" checksum="CDDBF2CEECF18819" modified="2009-03-03" version="1">MSKKAPDFTLPDQNGKEVSLSDYKGKWVVLYFYPKDMTSGCTKEAVSFSEKIDEFKKRNSVVIGISKDTVESHKKFAEKYNLEIILLSDKDAKVIKEYGAWGKKRMYGKETEGTLRNTFIISPEGEILHEWKNVKLDGHVEEVLKKLDELISAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1U8</accession>
    <name>B8E1U8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Superoxide reductase</fullName>
            <ecNumber evidence="7">1.15.1.2</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_0429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the desulfoferrodoxin family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582816.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352345.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0429"/>
    <dbReference type="EnsemblBacteria" id="ACK41731">
        <property type="protein sequence ID" value="ACK41731"/>
        <property type="gene ID" value="Dtur_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0429"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.453"/>
    <dbReference type="eggNOG" id="COG2033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118960_2_1_0"/>
    <dbReference type="InParanoid" id="B8E1U8"/>
    <dbReference type="OMA" id="HHIAWIE"/>
    <dbReference type="OrthoDB" id="1496450at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050605">
        <property type="term" value="F:superoxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002742">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036073">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01880">
        <property type="entry name" value="Desulfoferrodox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49367">
        <property type="entry name" value="SSF49367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00332">
        <property type="entry name" value="neela_ferrous"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrodox" evidence="6">
        <location>
            <begin position="11"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK41731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="129" mass="14711" checksum="1179BADC242CA6D9" modified="2009-03-03" version="1">MVNIKDLFQSADWAKEKHVPVIEILEKDKEKGVRIRVSVGKEIPHPNTTAHHIAWIEVYFQPEGDKYPYHVGRFEFVAHGATVQGPDTSTVYSEPVVEFVFKTQKDGVIFATSYCNIHGLWENSAELKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1V1</accession>
    <name>B8E1V1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Dtur_0432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582819.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352348.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0432"/>
    <dbReference type="EnsemblBacteria" id="ACK41734">
        <property type="protein sequence ID" value="ACK41734"/>
        <property type="gene ID" value="Dtur_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0432"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.456"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_815678_0_0_0"/>
    <dbReference type="OrthoDB" id="196885at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="1">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ACK41734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="340" mass="37522" checksum="35CC5DCF9D488A57" modified="2009-03-03" version="1">MKNSLKIILLVLSVVLIALLISGCAPKEQPPAVTKPFAPTNLVAEALSATEVRLTWQDNSNNEDGFKIERKKEGEDWTQIATVEANVTTFTDTGLNSNTKYYYRVKAYNSAGDSDYSNEAEVTTLVNWSVYDWTNTVEPPTGWIDGNLNYPMANFCTLQDGILKMDTTSNAAATPSFRFNFDSASCQPGSFKMTIVFKAKGEVGITNVTRAWTLDIQTTLYRGGFEIQPTQVRILNGTGTLVSTTGVTGADWHVYWFTIEYNLDGLYARLYVDGNPTPILEGNINAAPSTIPDPQFMRLGDTSTSTSNLYIGYIDWILWTFDGAFVPGQVQIPEGFSLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1X8</accession>
    <name>B8E1X8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IA, variant 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0461</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582846.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352375.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0461"/>
    <dbReference type="EnsemblBacteria" id="ACK41761">
        <property type="protein sequence ID" value="ACK41761"/>
        <property type="gene ID" value="Dtur_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0461"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_0"/>
    <dbReference type="InParanoid" id="B8E1X8"/>
    <dbReference type="OMA" id="LWDNDGL"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="217" mass="25188" checksum="A4D4612BF2730B7E" modified="2009-03-03" version="1">MKVSAVIFDMDGVIFDTERLGYIFWKKALEEFGYIINEEIYYETVGVNILETERIFKKYLGDIPFDEIYKRKKELIEEYIEKNGLPVKGGFFELLDFLDEKKIPRGIATSTERERAIPLLERAKILNKFDVIVCGDDVEKSKPEPDIFLLTAQRLKANPKECIVLEDSDNGVLAAKRAGMTPLLIIDFKPPHPETLKRAYKVFNSLWEVKEYLKEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Y0</accession>
    <name>B8E1Y0_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA repair photolyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_0463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012582848.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352377.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0463"/>
    <dbReference type="EnsemblBacteria" id="ACK41763">
        <property type="protein sequence ID" value="ACK41763"/>
        <property type="gene ID" value="Dtur_0463"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0463"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.489"/>
    <dbReference type="eggNOG" id="COG1533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030330_0_0_0"/>
    <dbReference type="InParanoid" id="B8E1Y0"/>
    <dbReference type="OMA" id="YHIGTGQ"/>
    <dbReference type="OrthoDB" id="1341636at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042601">
        <property type="term" value="C:endospore-forming forespore"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003913">
        <property type="term" value="F:DNA photolyase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK41763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="335" mass="39769" checksum="194286C64D0980F9" modified="2009-03-03" version="1">MKSLRTSLLSKPFSHIYVEKEIISHEITKEILKKFPNSQIITVNHYKEVFSRPRQNYKLQELSKKLILAKKREKFLSPASSLCQNFGHPYFYYANLIVNCIFNCDYCFLKGMYSSANIVIFVNIEDYFKEIDEILKKHPLYLSPSYETDLLAMEEIVPFFSRFVNYAYSKENLILEVRTKSVNYTAIKNLKPSPNIILAWTLLPQEIIERYEKTPNLSLRINTIKRAIHDGWKVRLSFDPIILVENWKEIYKKFIDYIFSEIPASKIQDITIGVFRIPKEYLKRMRKKFENEITLFPYVEDIDAYTYSPSTKEELLNFISSKVKNYIPEDKIYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>B8E1Y2</accession>
    <name>B8E1Y2_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Dtur_0465</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK41765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352379.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_0465"/>
    <dbReference type="EnsemblBacteria" id="ACK41765">
        <property type="protein sequence ID" value="ACK41765"/>
        <property type="gene ID" value="Dtur_0465"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_0465"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.491"/>
    <dbReference type="eggNOG" id="COG1914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_2_0_0"/>
    <dbReference type="InParanoid" id="B8E1Y2"/>
    <dbReference type="OMA" id="IATFVNS"/>
    <dbReference type="OrthoDB" id="416257at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071281">
        <property type="term" value="P:cellular response to iron ion"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ACK41765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="414" mass="45865" checksum="E6A8DDBB946B4524" modified="2009-03-03" version="1">MQRFLKGHKPTLGALEILKYIGPGFLVTVGFIDPGNWASNMAAGSQFGYKLLWMVTLSTIMLIFLQHNAAHLGIATGLCLSEAISKYFPKFLRYFVLVTAMLASISTALAEILGAAIGLNMLFNIPINIGAFITTIVVILMLLSNSYRKIEKYIIGFVSLIGLSFLFELSLVKINWKSAIQGWIIPSFPQNSIPIIMSVLGAVVMPHNLFLHSEIIQSRQWNLEDESIIRKQLKYEYLDTIGAMLVGWAINSSMILIAAEAFYKNGILITELPQAYLTLKPLLGHLASYVFAIALIFSGFSSSMTAGMAGGSTWAGMSNEPFDVKDNHTRIGILITLIGALFVIFFISNPFQGLIWSQIMLSIQLPFTIFSLIRLTSWEKVMGKFKNSKIDNIILITIGIIVTLLNITLFLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>B8E234</accession>
    <name>B8E234_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583394.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002352925.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1031"/>
    <dbReference type="EnsemblBacteria" id="ACK42311">
        <property type="protein sequence ID" value="ACK42311"/>
        <property type="gene ID" value="Dtur_1031"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1031"/>
    <dbReference type="eggNOG" id="COG4972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050686_0_2_0"/>
    <dbReference type="InParanoid" id="B8E234"/>
    <dbReference type="OMA" id="YFPINID"/>
    <dbReference type="OrthoDB" id="1750212at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="329" mass="37914" checksum="97D15581050F3156" modified="2009-03-03" version="1">MSLFSSEVPILSIEFGNPLRVIFGGKRKDKKVVIKNFALETLPPEIIQGGQLNNSDYLLEVLKSILKRFKLKSGKTLISIPAQNVIVRFFNFPYMPEEELRESIKWELERYVPLSPEDINYDIQVVSLVERGDIKESRVMLVAVPKEVLSPYLDVVKKLNLDPDLVDVSVFSAVRTVIMNRKDIPKGNTIYLYTHDNVAEFVVAKENQPLFFRSTVMEEWNPQEEVDDLTKSFMLEDFVRKIQEAVNFFYMQFPEEHIDQAIVTGSNAKNKDFIDLLEAILNVNTEVSPGSSVNINDLLVLNLKKQDKEFLGDIYSWVVPIGLFFWERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2B8</accession>
    <name>B8E2B8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Dtur_1116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583478.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353009.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1116"/>
    <dbReference type="EnsemblBacteria" id="ACK42395">
        <property type="protein sequence ID" value="ACK42395"/>
        <property type="gene ID" value="Dtur_1116"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1116"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_0"/>
    <dbReference type="InParanoid" id="B8E2B8"/>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ACK42395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="320" mass="34880" checksum="E0ED9E2A9D697C6D" modified="2009-03-03" version="1">MRKAVGVDLGGTKINVLLVNEKGEVLGRDKQPTEADRGKDYVINKIKDMIHNVLQQGRVSEKDIEGIGIGFPGLMDREKKSTLYAPNLGDEWKKEVFLGRELEEYFNVPTYLENDVNLIAWAEWLVGAGRGTKTMICVALGTGIGSGIVLNGKLWIGAHGMAGEFGHITVLPDGPICGCGNRGCIEAIASGTGIEKYARSILPQHTDSLIWGLCNGNLEEVTVKTIYQAAEQGDKLAIDIFNHAGYYLGIALANYVHIVDPEKIVIGGGVANVREYIGKPMREEFYRRVLPSFRDKVTFSWAELGEDAGGIGAALLALYR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2E7</accession>
    <name>GCSPA_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable glycine dehydrogenase (decarboxylating) subunit 1</fullName>
            <ecNumber evidence="1">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycine cleavage system P-protein subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycine decarboxylase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycine dehydrogenase (aminomethyl-transferring) subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gcvPA</name>
        <name type="ordered locus">Dtur_1517</name>
    </gene>
    <organism>
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvP family. N-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583867.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353405.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B8E2E7"/>
    <dbReference type="SMR" id="B8E2E7"/>
    <dbReference type="STRING" id="515635.Dtur_1517"/>
    <dbReference type="EnsemblBacteria" id="ACK42791">
        <property type="protein sequence ID" value="ACK42791"/>
        <property type="gene ID" value="Dtur_1517"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1517"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1566"/>
    <dbReference type="eggNOG" id="COG0403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_0_2_0"/>
    <dbReference type="InParanoid" id="B8E2E7"/>
    <dbReference type="OMA" id="MYDGASA"/>
    <dbReference type="OrthoDB" id="870147at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00613">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00712">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006815">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000147985" description="Probable glycine dehydrogenase (decarboxylating) subunit 1">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00712"/>
        </source>
    </evidence>
    <sequence length="453" mass="50912" checksum="3E381E07BC2054D0" modified="2009-03-03" version="1">MAYFPHTPQEIREMLNTIGVDSIEELFSEIPEEIRQKAKENFKLSASPSEIDLLEEIKQISKKNIGKDYISFLGGGAYRHYIPSFVKLVSLFPTFYTSYTPYQPEISQGVLQSIFEYQSLICDLTGMEVANASLYEAGSGIAEAALMSVRITGKKEVIVSSGLNPEYISVLKTYLQVQNIDLKILPLDENGETDITALERTISPSTSGVILQNPNFFGVIETKLKEMETLIHKNNALFILSIYPISLGILKPPSEYNVDIVVGEGQSLGIPLGFGGPYLGILATKKEFIRQIPGRIVGETIDLEGERGFVNTLQTREQHIRRAKATSNICTNEALSAISAAVYMALLGKKGIKKIAEVCFSRAHYLKDRLQKKLGIDFIYPNSYFFNEFVIKTPENSKVFLKKLEERKILGGIPLSKFYKEREKEILIAVTERNSIEEIDYYVKSLKEVLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2L8</accession>
    <name>B8E2L8_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Dtur_1589</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583937.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353476.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1589"/>
    <dbReference type="EnsemblBacteria" id="ACK42862">
        <property type="protein sequence ID" value="ACK42862"/>
        <property type="gene ID" value="Dtur_1589"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1589"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1639"/>
    <dbReference type="eggNOG" id="COG1175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_0_2_0"/>
    <dbReference type="InParanoid" id="B8E2L8"/>
    <dbReference type="OMA" id="WEKFWKI"/>
    <dbReference type="OrthoDB" id="1688736at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="79"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ACK42862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="305" mass="35221" checksum="7C94CA834717D236" modified="2009-03-03" version="1">MKKEKKLRTLSQRQARIGRLFVYPWLLGFLIFFAWPFIQSIIFAFSQLDVSPEGYNLIFVGFRNFIKALREDPNFVRYLTNEIGNMLVNIPLIIMFSLFIAILLNQKFRGRTFVRAIFFLPVVVMSGALLYVLESNSMEQFTMGAQAGMALSNSPFLRGIDFRLFLIRITGNIPFLMPVINAIDRIYEIIWKSGVQILIFLAGLQSIPTSLYEVAHVEGATAWETFWKVTLPMISPIILVNVIYTVIDSFTDYSNDVLRYILEVAFRQLNHGYSAAIAWLYFVIIGIVLLIIMWALSKRVFYMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2R5</accession>
    <name>B8E2R5_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Dtur_1136</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583497.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353029.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1136"/>
    <dbReference type="EnsemblBacteria" id="ACK42415">
        <property type="protein sequence ID" value="ACK42415"/>
        <property type="gene ID" value="Dtur_1136"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1136"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1173"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2R5"/>
    <dbReference type="OMA" id="MQEDYMR"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ACK42415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="309" mass="33964" checksum="0A519D6895609428" modified="2009-03-03" version="1">MLRYIIRRLLQAIPVFIGVTLITFILFFIAPGDPARLIAGQRADAETIARVRAMWGLDKPLPVQYLLFLGRIVRLDFGRSFKTNIPVIVSIGERLQATAVLAFFAFIIAVFLGVTAGIISAVRQYSLFDYTAMVVALLGVSAPVYWVGIILLLIFGFNLGWLPLGGYISEYGIKAVILPAITLGTRPAAYFARLSRSSMLEVIRQEYITTARAKGLPESKVIFKHALRNALIPVVTYAGMVVGDLLTGAVLTETIFAWPGIGRLVVQAILDRDLPVLQGGVIVIALIYILANLIVDLSYALIDPRIRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2T1</accession>
    <name>B8E2T1_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Basic membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Dtur_1152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BMP lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583513.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353045.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1152"/>
    <dbReference type="EnsemblBacteria" id="ACK42431">
        <property type="protein sequence ID" value="ACK42431"/>
        <property type="gene ID" value="Dtur_1152"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1152"/>
    <dbReference type="eggNOG" id="COG1744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038813_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2T1"/>
    <dbReference type="OMA" id="LASMMKR"/>
    <dbReference type="OrthoDB" id="603910at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003760">
        <property type="entry name" value="PnrA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02608">
        <property type="entry name" value="Bmp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Bmp" evidence="3">
        <location>
            <begin position="30"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ACK42431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="337" mass="36789" checksum="314E51678B5EE37A" modified="2009-03-03" version="1">MRKIFVLFLILSFVGLMSIGFSAKTVRVGIVYDVGGRGDKSFNDAAYAGLQRAIKVLKVEGKDLEPGPGGANREELLRTLAEQNYDLVVGVGFLFTDAITAVAKDFPKVKFAIVDGVIEGLPNVSSLVFNEHEGSFLVGVVAGLMTKTNVIGFVGGMDMPLIHKFEVGYKAGAMYVNPKVKVLINYIGVTGEAFKDPVKGKELALAQYKQGADIIYHASGASGEGVFEAAKETNKYAIGVDSPQSWIMPDRIITSMLKRVDVAVYETIKDVKEGKFKSGIRVFGLQNNGVDYERTKLLPLGVVQKVEQIKKEIIAGKIVVPYDDKTFEEFKAKYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>B8E2Y0</accession>
    <name>B8E2Y0_DICTD</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ordered locus">Dtur_1201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583562.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353094.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1201"/>
    <dbReference type="EnsemblBacteria" id="ACK42480">
        <property type="protein sequence ID" value="ACK42480"/>
        <property type="gene ID" value="Dtur_1201"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1201"/>
    <dbReference type="PATRIC" id="fig|515635.4.peg.1239"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_0"/>
    <dbReference type="InParanoid" id="B8E2Y0"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006225">
        <property type="term" value="P:UDP biosynthetic process"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="6">
        <location>
            <begin position="19"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="11"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ACK42480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="249" mass="27429" checksum="67A5EEE3DDC7BDE6" modified="2009-03-03" version="1">MEPKYKRILLKISGESFSGEQGFGLNPDCIRSIAEDIKEVHDLGVEIGVVVGGGNFFRGRESKILGIDRVTADYMGMLATTINALALQDMLEKMGVITRVQTGIEMRQIAEPFIRRRAIRHLEKGRVVIFAAGTGNPFFSTDTAAALRAAEIKAEVILKETKVDGVYNKDPLKYPDAEKFETIEPIEFLKLRLQALDATAVSLCMDNKIPIIVFNMSVRGNLKRVILGEKVGTYIGDVEIIPDKGGENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2009-03-03" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>B8E347</accession>
    <name>B8E347_DICTD</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GumN family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Dtur_1648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dictyoglomus turgidum (strain DSM 6724 / Z-1310)</name>
        <dbReference type="NCBI Taxonomy" id="515635"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Dictyoglomi</taxon>
            <taxon>Dictyoglomales</taxon>
            <taxon>Dictyoglomaceae</taxon>
            <taxon>Dictyoglomus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="journal article" date="2016" name="Front. Microbiol." volume="7" first="1979" last="1979">
            <title>The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724 reveals a specialized carbohydrate fermentor.</title>
            <authorList>
                <person name="Brumm P.J."/>
                <person name="Gowda K."/>
                <person name="Robb F.T."/>
                <person name="Mead D.A."/>
            </authorList>
            <dbReference type="PubMed" id="28066333"/>
            <dbReference type="DOI" id="10.3389/fmicb.2016.01979"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 6724 / Z-1310</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP001251">
        <property type="protein sequence ID" value="ACK42921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_012583996.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_002353535.1">
        <property type="nucleotide sequence ID" value="NC_011661.1"/>
    </dbReference>
    <dbReference type="STRING" id="515635.Dtur_1648"/>
    <dbReference type="EnsemblBacteria" id="ACK42921">
        <property type="protein sequence ID" value="ACK42921"/>
        <property type="gene ID" value="Dtur_1648"/>
    </dbReference>
    <dbReference type="KEGG" id="dtu:Dtur_1648"/>
    <dbReference type="eggNOG" id="COG3735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057525_0_0_0"/>
    <dbReference type="InParanoid" id="B8E347"/>
    <dbReference type="OMA" id="VYLELDM"/>
    <dbReference type="OrthoDB" id="1991552at2"/>
    <dbReference type="Proteomes" id="UP000007719">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0000318"/>
        <property type="project" value="GO_Central"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030178">
        <property type="term" value="P:negative regulation of Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040230">
        <property type="entry name" value="TIKI1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002816">
        <property type="entry name" value="TraB/PrgY/GumN_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31120">
        <property type="entry name" value="PTHR31120"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01963">
        <property type="entry name" value="TraB_PrgY_gumN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ACK42921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007719"/>
        </source>
    </evidence>
    <sequence length="295" mass="34385" checksum="0803ADD71B71A50F" modified="2009-03-03" version="1">MKYLKRLISFVIISILLLNFVFCGTKGIFYEVRSDYGKAYILGSIHYGTPDLYPLDPLIEKVFIETEALVVELDITDSQNIFKTQSYLSRRGIYKKGDSIENYLDSESVGYLKKLLGEENFEQIKIFKPWVLLLQISSSVLNSASDMRYGIDFYFLNRAKKLNKKIIPLETVEEQLDAFSEIPEEDQLNILKTILQGLKQEEHSKNDLSLLLDAYKNGDEEKLLNFLMKDREKKEYKIFYEHIFYRRNFKFAERIKRLLGEYKSLFIVVGAGHLIGENNVIKLLESEGFLGSKIF</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>